TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 446.487 | Formula: C19H25F3N4O3S
H donors: 0 H acceptors: 5 LogP: 2.03 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ncc(cn1)C(F)(F)F)(C)C
InChi: 1S/C19H25F3N4O3S/c1-17(2)13-3-4-18(17,15(27)9-13)12-30(28,29)26-7-5-25(6-8-26)16-23-10-14(11-24-16)19(20,21)22/h10-11,13H,3-9,12H2,1-2H3/t13-,18-/m1/s1
InChiKey: LNRFZPWGNHLMFR-FZKQIMNGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	chemokine (C-X-C motif) receptor 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	serine/threonine-protein kinase	0.0111	0.0119	0.0107
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Brugia malayi	protein-tyrosine kinase	0.0063	0.0037	0.0032
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0063	0.0037	0.0032
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0063	0.0037	0.0039
Loa Loa (eye worm)	TK/FER protein kinase	0.0063	0.0037	0.0032
Echinococcus granulosus	Immunoglobulin	0.0117	0.0129	0.0148
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0063	0.0037	0.0039
Onchocerca volvulus		0.0088	0.0079	0.026
Echinococcus granulosus	plexin a4	0.1188	0.1962	0.2341
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Loa Loa (eye worm)	TK protein kinase	0.0063	0.0037	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0037	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0037	0.0032
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Brugia malayi	C-terminal src kinase protein 1	0.0063	0.0037	0.0032
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0079	0.0506
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Brugia malayi	integrin-linked kinase	0.0063	0.0037	0.0032
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0111	0.0119	1
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0063	0.0037	0.0025
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0088	0.0079	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0078	0.0502
Echinococcus granulosus	activated cdc42 kinase 1	0.0063	0.0037	0.0039
Echinococcus multilocularis	Pleckstrin y	0.0088	0.0079	0.0089
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0088	0.0079	0.0274
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0088	0.0079	0.0506
Trichomonas vaginalis	centaurin/arf, putative	0.0088	0.0079	0.0506
Brugia malayi	Cytohesin 3	0.0088	0.0079	0.0074
Loa Loa (eye worm)	TK/Met protein kinase	0.0063	0.0037	0.0032
Echinococcus multilocularis	oxysterol binding protein 1	0.0088	0.0079	0.0089
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0063	0.0037	0.0039
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0063	0.0037	0.0032
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Schistosoma mansoni	protein kinase	0.0087	0.0077	0.0066
Brugia malayi	PH domain containing protein	0.0088	0.0079	0.0074
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0079	0.0074
Brugia malayi	SRC-1	0.0063	0.0037	0.0032
Echinococcus multilocularis	Oxysterol binding protein 11	0.0088	0.0079	0.0089
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0063	0.0037	0.0032
Trichomonas vaginalis	alpha chimerin, putative	0.0088	0.0079	0.0506
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0063	0.0037	0.0039
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0087	0.0077	0.0087
Schistosoma mansoni	zinc finger protein	0.0088	0.0079	0.0067
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Trypanosoma cruzi	hypothetical protein	0.0088	0.0079	0.5099
Trypanosoma cruzi	PH domain containing protein, putative	0.0088	0.0079	0.5099
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0079	0.0074
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Brugia malayi	Sema domain containing protein	0.0425	0.0656	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0079	0.0074
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Echinococcus granulosus	raf serine:threonine protein kinase	0.0063	0.0037	0.0039
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0088	0.0079	0.5099
Trichomonas vaginalis	conserved hypothetical protein	0.0186	0.0248	0.1585
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0129	0.0124
Trypanosoma brucei	protein kinase, putative	0.0111	0.0119	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0063	0.0037	0.0039
Echinococcus granulosus	pleckstrin y domain containing family A	0.0088	0.0079	0.0089
Echinococcus granulosus	tyrosine kinase	0.0063	0.0037	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0425	0.0656	0.0651
Entamoeba histolytica	hypothetical protein	0.0088	0.0079	0.0274
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0088	0.0079	0.0089
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0087	0.0078	0.5029
Leishmania major	protein kinase, putative	0.0087	0.0077	0.4901
Loa Loa (eye worm)	hypothetical protein	0.0955	0.1562	0.1558
Schistosoma mansoni	protein kinase	0.0087	0.0078	0.0067
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0079	0.0506
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0063	0.0037	0.0039
Echinococcus granulosus	neuroglian	0.0117	0.0129	0.0148
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Loa Loa (eye worm)	TK/FER protein kinase	0.0063	0.0037	0.0032
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0088	0.0079	0.0089
Brugia malayi	serine/threonine-protein kinase 6	0.0087	0.0078	0.0073
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Toxoplasma gondii	hypothetical protein	0.0088	0.0079	0.5099
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0088	0.0079	0.0089
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Trichomonas vaginalis	conserved hypothetical protein	0.0186	0.0248	0.1585
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0063	0.0037	0.0032
Loa Loa (eye worm)	TK/FER protein kinase	0.0063	0.0037	0.0032
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0063	0.0037	0.0039
Leishmania major	serine/threonine-protein kinase a, putative	0.0111	0.0119	1
Echinococcus multilocularis	protein kinase	0.0063	0.0037	0.0039
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0138	0.0133
Entamoeba histolytica	hypothetical protein, conserved	0.0088	0.0079	0.0274
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0079	0.0506
Toxoplasma gondii	Oxysterol-binding protein	0.0088	0.0079	0.5099
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0063	0.0037	0.0039
Echinococcus granulosus	natriuretic peptide receptor 1	0.0063	0.0037	0.0039
Loa Loa (eye worm)	SRC-1	0.0063	0.0037	0.0032
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0063	0.0037	0.0025
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0063	0.0037	0.0025
Echinococcus granulosus	cytohesin 1	0.0088	0.0079	0.0089
Brugia malayi	Protein kinase domain containing protein	0.0326	0.0487	0.0482
Loa Loa (eye worm)	TK/FER protein kinase	0.0063	0.0037	0.0032
Schistosoma mansoni	protein kinase	0.0063	0.0037	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0037	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0425	0.0656	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0955	0.1562	0.1558
Entamoeba histolytica	hypothetical protein	0.0955	0.1562	1
Loa Loa (eye worm)	uncoordinated protein 104	0.0088	0.0079	0.0074
Echinococcus multilocularis	tyrosine protein kinase shark	0.0063	0.0037	0.0039
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Schistosoma mansoni	oxysterol-binding protein 1	0.0088	0.0079	0.0067
Loa Loa (eye worm)	TK protein kinase	0.0063	0.0037	0.0032
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Echinococcus granulosus	c src tyrosine kinase	0.0063	0.0037	0.0039
Brugia malayi	PH domain containing protein	0.0088	0.0079	0.0074
Schistosoma mansoni	serine/threonine protein kinase	0.0063	0.0037	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0037	0.0032
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.4933	0.8367	0.8366
Entamoeba histolytica	p21-activated kinase	0.0111	0.0119	0.0538
Trichomonas vaginalis	hypothetical protein	0.0088	0.0079	0.0506
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Echinococcus granulosus	kinase suppressor of Ras 1	0.0063	0.0037	0.0039
Onchocerca volvulus	Protein melted homolog	0.0088	0.0079	0.026
Loa Loa (eye worm)	hypothetical protein	0.0955	0.1562	0.1558
Echinococcus multilocularis	integrin linked protein kinase	0.0063	0.0037	0.0039
Loa Loa (eye worm)	TK/ACK protein kinase	0.0063	0.0037	0.0032
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0037	0.0238
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0955	0.1562	0.1558
Echinococcus multilocularis	tyrosine protein kinase	0.0063	0.0037	0.0039
Brugia malayi	DNA-binding protein LAG-1	0.0186	0.0248	0.0243
Leishmania major	hypothetical protein, conserved	0.0088	0.0079	0.5099
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0425	0.0656	0.0651
Echinococcus multilocularis	beta adrenergic receptor kinase	0.4513	0.7649	0.9141
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0111	0.0119	1
Echinococcus granulosus	Pleckstrin y	0.0088	0.0079	0.0089
Trichomonas vaginalis	conserved hypothetical protein	0.0186	0.0248	0.1585
Loa Loa (eye worm)	TK/FER protein kinase	0.0063	0.0037	0.0032
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0063	0.0037	0.0032
Loa Loa (eye worm)	TK/RYK protein kinase	0.0063	0.0037	0.0032
Schistosoma mansoni	z-protein (S1r protein)	0.0955	0.1562	0.1552
Brugia malayi	probable spectrin beta chain	0.0088	0.0079	0.0074
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0063	0.0037	0.0032
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0079	0.0506
Loa Loa (eye worm)	TK/FER protein kinase	0.0063	0.0037	0.0032
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0079	0.0506
Loa Loa (eye worm)	PH domain-containing protein	0.0088	0.0079	0.0074
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.018	0.0237	0.0232
Trypanosoma brucei	protein kinase, putative	0.0087	0.0077	0.4901
Loa Loa (eye worm)	syntrophin-1	0.0088	0.0079	0.0074
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0088	0.0079	0.0089
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Trypanosoma cruzi	hypothetical protein	0.0088	0.0079	0.5099
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0088	0.0079	0.0274
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0088	0.0079	0.5099
Echinococcus granulosus	Pleckstrin y	0.0088	0.0079	0.0089
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0079	0.0506
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Plasmodium falciparum	protein kinase, putative	0.0087	0.0077	0.4901
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Echinococcus multilocularis	Immunoglobulin	0.0117	0.0129	0.0148
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0063	0.0037	0.0032
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0087	0.0078	0.0088
Schistosoma mansoni	cell adhesion molecule	0.0122	0.0138	0.0127
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0088	0.0079	0.026
Trichomonas vaginalis	conserved hypothetical protein	0.0186	0.0248	0.1585
Leishmania major	protein kinase, putative	0.0111	0.0119	1
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0088	0.0079	0.5099
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0248	0.0243
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0088	0.0079	0.5099
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0037	0.0032
Onchocerca volvulus		0.0088	0.0079	0.026
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Plasmodium falciparum	oxysterol-binding protein, putative	0.0088	0.0079	0.5099
Trypanosoma cruzi	hypothetical protein	0.0088	0.0079	0.5099
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0088	0.0079	0.5099
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0088	0.0079	0.0274
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0063	0.0037	0.0039
Echinococcus granulosus	regulator of G protein signaling 3	0.0955	0.1562	0.1862
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0088	0.0079	0.0089
Schistosoma mansoni	myotubularin-related protein	0.0088	0.0079	0.0067
Echinococcus multilocularis	FL cytokine receptor	0.0063	0.0037	0.0039
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Echinococcus granulosus	tyrosine protein kinase pr2	0.0063	0.0037	0.0039
Trichomonas vaginalis	conserved hypothetical protein	0.0186	0.0248	0.1585
Echinococcus granulosus	tyrosine protein kinase HCK	0.0063	0.0037	0.0039
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0111	0.0119	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0079	0.0074
Trypanosoma brucei	PH domain containing protein, putative	0.0088	0.0079	0.5099
Brugia malayi	PH domain containing protein	0.0088	0.0079	0.0074
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0111	0.0119	1
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0063	0.0037	0.0032
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0088	0.0079	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0079	0.0074
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0063	0.0037	0.0032
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0088	0.0079	0.0274
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Brugia malayi	hypothetical protein	0.0063	0.0037	0.0032
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0088	0.0079	0.5099
Brugia malayi	A-kinase anchor protein 10, precursor	0.0955	0.1562	0.1558
Echinococcus granulosus	ephrin type A receptor 4 A	0.0063	0.0037	0.0039
Entamoeba histolytica	protein kinase , putative	0.0087	0.0078	0.027
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0078	0.0502
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0063	0.0037	0.0032
Trichomonas vaginalis	TK family protein kinase	0.0063	0.0037	0.0238
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0088	0.0079	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0037	0.0032
Schistosoma mansoni	hypothetical protein	0.0088	0.0079	0.0067
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0063	0.0037	0.0039
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0117	0.0129	0.0117
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0063	0.0037	0.0039
Echinococcus multilocularis	Pleckstrin y	0.0088	0.0079	0.0089
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0063	0.0037	0.0039
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0088	0.0079	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0079	0.0074
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Entamoeba histolytica	protein kinase, putative	0.0087	0.0078	0.027
Loa Loa (eye worm)	sema domain-containing protein	0.0425	0.0656	0.0651
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0117	0.0129	0.0117
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0079	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0037	0.0032
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0111	0.0119	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0063	0.0037	0.0032
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0111	0.0119	1
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0088	0.0079	0.0067
Loa Loa (eye worm)	TK/FER protein kinase	0.0063	0.0037	0.0032
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0111	0.0119	1
Entamoeba histolytica	hypothetical protein	0.0186	0.0248	0.138
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0186	0.0248	0.1585
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0088	0.0079	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0079	0.0074
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0037	0.0238
Entamoeba histolytica	tyrosin kinase, putative	0.0249	0.0356	0.2088
Echinococcus granulosus	dynamin 1	0.0088	0.0079	0.0089
Loa Loa (eye worm)	AUR protein kinase	0.0087	0.0078	0.0073
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Trichomonas vaginalis	CAMK family protein kinase	0.0063	0.0037	0.0238
Loa Loa (eye worm)	TK/FER protein kinase	0.0063	0.0037	0.0032
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0088	0.0079	0.0089
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.3558	0.6016	0.7188
Echinococcus multilocularis	regulator of G protein signaling 7	0.0955	0.1562	0.1862
Brugia malayi	IPT/TIG domain containing protein	0.0186	0.0248	0.0243
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Echinococcus granulosus	tyrosine kinase	0.0063	0.0037	0.0039
Trypanosoma cruzi	PH domain containing protein, putative	0.0088	0.0079	0.5099
Loa Loa (eye worm)	TK protein kinase	0.0063	0.0037	0.0032
Echinococcus granulosus	oxysterol binding protein 1	0.0088	0.0079	0.0089
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Trichomonas vaginalis	centaurin/arf, putative	0.0088	0.0079	0.0506
Echinococcus multilocularis	myotubularin protein 13	0.0088	0.0079	0.0089
Schistosoma mansoni	regulator of G protein signaling	0.0955	0.1562	0.1552
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0087	0.0078	0.0088
Brugia malayi	hypothetical protein	0.0063	0.0037	0.0032
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0063	0.0037	0.0039
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0088	0.0079	0.0506
Trypanosoma cruzi	NIMA-related kinase, putative	0.0111	0.0119	1
Echinococcus multilocularis	insulin receptor	0.0063	0.0037	0.0039
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0088	0.0079	0.0274
Entamoeba histolytica	hypothetical protein	0.0088	0.0079	0.0274
Echinococcus granulosus	tyrosine protein kinase csk	0.0063	0.0037	0.0039
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0063	0.0037	0.0025
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Echinococcus granulosus	Regulator of G protein signaling 20	0.0955	0.1562	0.1862
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0088	0.0079	0.5099
Schistosoma mansoni	protein kinase	0.0063	0.0037	0.0025
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0063	0.0037	0.0039
Schistosoma mansoni	semaphorin 5-related	0.0425	0.0656	0.0645
Schistosoma mansoni	regulator of G protein signaling	0.0955	0.1562	0.1552
Schistosoma mansoni	regulator of G protein signaling	0.0955	0.1562	0.1552
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0955	0.1562	0.1862
Echinococcus multilocularis	hypothetical protein	0.0425	0.0656	0.0778
Loa Loa (eye worm)	hypothetical protein	0.1002	0.1644	0.164
Echinococcus multilocularis	tyrosine kinase	0.0063	0.0037	0.0039
Brugia malayi	hypothetical protein	0.0063	0.0037	0.0032
Brugia malayi	Fibronectin type III domain containing protein	0.0122	0.0138	0.0133
Loa Loa (eye worm)	TK/FER protein kinase	0.0063	0.0037	0.0032
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0063	0.0037	0.0032
Entamoeba histolytica	hypothetical protein	0.0186	0.0248	0.138
Entamoeba histolytica	protein kinase, putative	0.0087	0.0078	0.027
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0063	0.0037	0.0039
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Brugia malayi	Syntrophin-1	0.0088	0.0079	0.0074
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0079	0.0506
Brugia malayi	hypothetical protein	0.0955	0.1562	0.1558
Loa Loa (eye worm)	TK/FER protein kinase	0.0063	0.0037	0.0032
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0111	0.0119	1
Echinococcus granulosus	protein kinase	0.0063	0.0037	0.0039
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0087	0.0077	0.4901
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0079	0.0506
Schistosoma mansoni	serine/threonine protein kinase	0.5887	1	1
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0088	0.0079	0.0089
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0063	0.0037	0.0039
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0111	0.0119	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0063	0.0037	0.0032
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.5887	1	1
Schistosoma mansoni	ephrin receptor	0.0063	0.0037	0.0025
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Loa Loa (eye worm)	serine/threonine protein kinase	0.0063	0.0037	0.0032
Schistosoma mansoni	centaurin alpha	0.0088	0.0079	0.0067
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0063	0.0037	0.0039
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0111	0.0119	0.0538
Echinococcus multilocularis	transfer RNA-Thr	0.0063	0.0037	0.0039
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0138	0.0133
Loa Loa (eye worm)	TK/FER protein kinase	0.0063	0.0037	0.0032
Brugia malayi	Variant SH3 domain containing protein	0.0088	0.0079	0.0074
Echinococcus granulosus	myotubularin protein 13	0.0088	0.0079	0.0089
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Schistosoma mansoni	hypothetical protein	0.0186	0.0248	0.0236
Trichomonas vaginalis	protein transport protein sec7, putative	0.0088	0.0079	0.0506
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0079	0.0506
Loa Loa (eye worm)	TK/FER protein kinase	0.0063	0.0037	0.0032
Schistosoma mansoni	goodpasture antigen-binding protein	0.0088	0.0079	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0037	0.0032
Schistosoma mansoni	vesicular amine transporter	0.012	0.0134	0.0122
Echinococcus multilocularis	cytohesin 1	0.0088	0.0079	0.0089
Entamoeba histolytica	hypothetical protein	0.0088	0.0079	0.0274
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0063	0.0037	0.0039
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Echinococcus granulosus	pdz domain containing protein	0.0088	0.0079	0.0089
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0186	0.0248	0.1585
Schistosoma mansoni	serine/threonine protein kinase	0.0063	0.0037	0.0025
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0063	0.0037	0.0039
Echinococcus granulosus	Oxysterol binding protein 11	0.0088	0.0079	0.0089
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Brugia malayi	Protein kinase domain containing protein	0.0111	0.0119	0.0114
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0088	0.0079	0.0506
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0063	0.0037	0.0039
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0078	0.0502
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0088	0.0079	0.0274
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Schistosoma mansoni	axis inhibition protein axin	0.0955	0.1562	0.1552
Schistosoma mansoni	plexin	0.1002	0.1644	0.1634
Echinococcus multilocularis	tyrosine kinase	0.0063	0.0037	0.0039
Plasmodium falciparum	PH domain-containing protein, putative	0.0088	0.0079	0.5099
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0088	0.0079	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0129	0.0124
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0063	0.0037	0.0032
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0063	0.0037	0.0039
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0111	0.0119	0.0763
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0079	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0079	0.0074
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0111	0.0119	0.0538
Schistosoma mansoni	dynamin	0.0088	0.0079	0.0067
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0088	0.0079	0.0089
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0087	0.0078	0.027
Loa Loa (eye worm)	hypothetical protein	0.0231	0.0325	0.032
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0088	0.0079	0.0274
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Loa Loa (eye worm)	TK/INSR protein kinase	0.0063	0.0037	0.0032
Loa Loa (eye worm)	TK/FER protein kinase	0.0063	0.0037	0.0032
Echinococcus granulosus	serine/threonine protein kinase	0.0111	0.0119	0.0137
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Schistosoma mansoni	fibrocystin l	0.0186	0.0248	0.0236
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0079	0.0506
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0063	0.0037	0.0039
Leishmania major	hypothetical protein, conserved	0.0088	0.0079	0.5099
Echinococcus multilocularis	beta 1 syntrophin	0.0088	0.0079	0.0089
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0063	0.0037	0.0039
Loa Loa (eye worm)	PXA domain-containing protein	0.0955	0.1562	0.1558
Brugia malayi	Oxysterol binding protein	0.0088	0.0079	0.0074
Entamoeba histolytica	protein kinase, putative	0.0111	0.0119	0.0538
Echinococcus granulosus	tyrosine protein kinase Srms	0.0063	0.0037	0.0039
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0063	0.0037	0.0039
Echinococcus multilocularis	heat shock protein 70	0.0063	0.0037	0.0039
Entamoeba histolytica	protein kinase, putative	0.0111	0.0119	0.0538
Entamoeba histolytica	PH domain containing protein	0.0088	0.0079	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0079	0.0074
Loa Loa (eye worm)	AUR protein kinase	0.0087	0.0078	0.0073
Echinococcus granulosus	regulator of G protein signaling 7	0.0955	0.1562	0.1862
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0088	0.0079	0.0089
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.4933	0.8367	0.8366
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0088	0.0079	0.0506
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0088	0.0079	0.0089
Schistosoma mansoni	regulator of G protein signaling	0.0955	0.1562	0.1552
Brugia malayi	Raf kinase	0.0063	0.0037	0.0032
Onchocerca volvulus		0.0088	0.0079	0.026
Echinococcus multilocularis	epidermal growth factor receptor	0.0063	0.0037	0.0039
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0063	0.0037	0.0039
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0063	0.0037	0.0039
Loa Loa (eye worm)	TK/ROR protein kinase	0.0063	0.0037	0.0032
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0088	0.0079	0.0089
Schistosoma mansoni	hypothetical protein	0.0088	0.0079	0.0067
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Echinococcus granulosus	roundabout 2	0.0122	0.0138	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0955	0.1562	0.1558
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Schistosoma mansoni	zinc finger protein	0.0088	0.0079	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0037	0.0032
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0111	0.0119	1
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.4933	0.8367	1
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0248	0.0243
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0063	0.0037	0.0039
Echinococcus granulosus	twitchin	0.014	0.0169	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0079	0.0074
Schistosoma mansoni	regulator of G protein signaling	0.0955	0.1562	0.1552
Echinococcus multilocularis	tyrosine protein kinase csk	0.0063	0.0037	0.0039
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0063	0.0037	0.0032
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Echinococcus granulosus	exocyst complex component 2	0.0186	0.0248	0.029
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0088	0.0079	0.0089
Echinococcus multilocularis	activated cdc42 kinase 1	0.0063	0.0037	0.0039
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0088	0.0079	0.0089
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Entamoeba histolytica	protein kinase, putative	0.0111	0.0119	0.0538
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Echinococcus multilocularis	dynamin 1	0.0088	0.0079	0.0089
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0129	0.0124
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0079	0.0506
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0063	0.0037	0.0039
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0111	0.0119	0.0538
Echinococcus multilocularis	tyrosine protein kinase csk	0.0063	0.0037	0.0039
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0129	0.0124
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0088	0.0079	0.0074
Echinococcus multilocularis	actin binding protein anillin	0.0088	0.0079	0.0089
Trichomonas vaginalis	AGC family protein kinase	0.0063	0.0037	0.0238
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0063	0.0037	0.0025
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0063	0.0037	0.0039
Brugia malayi	Furin-like cysteine rich region family protein	0.0063	0.0037	0.0032
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.4513	0.7649	0.7647
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0087	0.0077	0.0087
Echinococcus granulosus	epidermal growth factor receptor	0.0063	0.0037	0.0039
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0088	0.0079	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0079	0.0074
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0088	0.0079	0.0089
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0063	0.0037	0.0039
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0088	0.0079	0.0089
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0111	0.0119	1
Trichomonas vaginalis	centaurin gamma, putative	0.0088	0.0079	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0079	0.0074
Schistosoma mansoni	serine/threonine protein kinase	0.0087	0.0078	0.0067
Schistosoma mansoni	serine/threonine RGC	0.0063	0.0037	0.0025
Echinococcus multilocularis	transcription factor collier	0.0186	0.0248	0.029
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0111	0.0119	1
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Loa Loa (eye worm)	RGS-3 protein	0.0955	0.1562	0.1558
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0063	0.0037	0.0039
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Trypanosoma cruzi	hypothetical protein	0.0088	0.0079	0.5099
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0063	0.0037	0.0039
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Schistosoma mansoni	growth factor receptor-bound protein	0.0088	0.0079	0.0067
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0088	0.0079	0.0089
Schistosoma mansoni	serine/threonine protein kinase	0.0063	0.0037	0.0025
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0063	0.0037	0.0238
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0037	0.0238
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0955	0.1562	0.1862
Echinococcus multilocularis	tyrosine protein kinase csk	0.0063	0.0037	0.0039
Echinococcus multilocularis	axis inhibition protein axin	0.0955	0.1562	0.1862
Echinococcus granulosus	tyrosine protein kinase csk	0.0063	0.0037	0.0039
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Echinococcus multilocularis	regulator of G protein signaling	0.0955	0.1562	0.1862
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0088	0.0079	0.5099
Echinococcus granulosus	semaphorin 5B	0.0425	0.0656	0.0778
Brugia malayi	PH domain containing protein	0.0088	0.0079	0.0074
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Entamoeba histolytica	protein kinase, putative	0.0111	0.0119	0.0538
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0063	0.0037	0.0025
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Trichomonas vaginalis	conserved hypothetical protein	0.0955	0.1562	1
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0088	0.0079	0.0089
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Echinococcus multilocularis	regulator of G protein signaling 3	0.0955	0.1562	0.1862
Trichomonas vaginalis	conserved hypothetical protein	0.0186	0.0248	0.1585
Toxoplasma gondii	AtPH1 family protein	0.0088	0.0079	0.5099
Trypanosoma cruzi	NIMA-related kinase, putative	0.0111	0.0119	1
Schistosoma mansoni	oxysterol-binding protein 1	0.0088	0.0079	0.0067
Schistosoma mansoni	protein kinase	0.0063	0.0037	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Echinococcus multilocularis	neuroglian	0.0117	0.0129	0.0148
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0111	0.0119	1
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0037	0.0032
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0063	0.0037	0.0039
Entamoeba histolytica	hypothetical protein	0.0186	0.0248	0.138
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0088	0.0079	0.026
Onchocerca volvulus		0.0088	0.0079	0.026
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Schistosoma mansoni	protein kinase	0.0087	0.0077	0.0066
Brugia malayi	Tyrosine-protein kinase PR2	0.0063	0.0037	0.0032
Schistosoma mansoni	hypothetical protein	0.0425	0.0656	0.0645
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Brugia malayi	regulator of G-protein signaling rgs-7	0.0955	0.1562	0.1558
Echinococcus granulosus	Pleckstrin y	0.0088	0.0079	0.0089
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0088	0.0079	0.0274
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0955	0.1562	0.1552
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Echinococcus multilocularis	Pleckstrin y	0.0088	0.0079	0.0089
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0063	0.0037	0.0039
Schistosoma mansoni	rho gtpase activating protein	0.0088	0.0079	0.0067
Trypanosoma cruzi	PH domain containing protein, putative	0.0088	0.0079	0.5099
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0129	0.0124
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0078	0.0502
Echinococcus multilocularis	Immunoglobulin	0.0117	0.0129	0.0148
Brugia malayi	PH domain containing protein	0.0088	0.0079	0.0074
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0063	0.0037	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0425	0.0656	0.0651
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0088	0.0079	0.0274
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.0037	0.0032
Trichomonas vaginalis	conserved hypothetical protein	0.0955	0.1562	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0111	0.0119	0.0538
Echinococcus multilocularis	c src tyrosine kinase	0.0063	0.0037	0.0039
Brugia malayi	PH domain containing protein	0.0088	0.0079	0.0074
Entamoeba histolytica	hypothetical protein	0.0186	0.0248	0.138
Entamoeba histolytica	hypothetical protein	0.0111	0.0119	0.0538
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0063	0.0037	0.0039
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Loa Loa (eye worm)	plexin A	0.1188	0.1962	0.1958
Brugia malayi	Plexin repeat family protein	0.1002	0.1644	0.164
Echinococcus granulosus	Rho GTPase activating protein 24	0.0088	0.0079	0.0089
Onchocerca volvulus	outspread protein homolog	0.0088	0.0079	0.026
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Echinococcus granulosus	axis inhibition protein axin	0.0955	0.1562	0.1862
Entamoeba histolytica	PH domain containing protein	0.0088	0.0079	0.0274
Echinococcus multilocularis	exocyst complex component 2	0.0186	0.0248	0.029
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Brugia malayi	Receptor family ligand binding region containing protein	0.0063	0.0037	0.0032
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0037	0.0032
Onchocerca volvulus		0.0088	0.0079	0.026
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0063	0.0037	0.0032
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.4933	0.8367	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0069	0.0046	0.005
Brugia malayi	hypothetical protein	0.0088	0.0079	0.0074
Schistosoma mansoni	hypothetical protein	0.0186	0.0248	0.0236
Echinococcus granulosus	oxysterol binding protein 9	0.0088	0.0079	0.0089
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0063	0.0037	0.0039
Echinococcus multilocularis	roundabout 2	0.0122	0.0138	0.0159
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0088	0.0079	0.0274
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0079	0.0506
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0088	0.0079	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0079	0.0074
Trypanosoma cruzi	hypothetical protein	0.0088	0.0079	0.5099
Schistosoma mansoni	hypothetical protein	0.0088	0.0079	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0079	0.0074
Loa Loa (eye worm)	TK/FER protein kinase	0.0063	0.0037	0.0032
Entamoeba histolytica	hypothetical protein	0.0955	0.1562	1
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0088	0.0079	0.0089
Loa Loa (eye worm)	oxysterol binding protein	0.0088	0.0079	0.0074
Trichomonas vaginalis	conserved hypothetical protein	0.0955	0.1562	1
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0063	0.0037	0.0039
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0088	0.0079	0.0067
Echinococcus multilocularis	rac serine:threonine kinase	0.0111	0.0119	0.0137
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0063	0.0037	0.0238
Loa Loa (eye worm)	TK/DDR protein kinase	0.0063	0.0037	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0425	0.0656	0.0651
Loa Loa (eye worm)	cytohesin 3	0.0088	0.0079	0.0074
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Loa Loa (eye worm)	TK/ABL protein kinase	0.0063	0.0037	0.0032
Brugia malayi	hypothetical protein	0.0122	0.0138	0.0133
Echinococcus granulosus	tyrosine protein kinase shark	0.0063	0.0037	0.0039
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Echinococcus granulosus	DCC interacting protein 13 beta	0.0088	0.0079	0.0089
Echinococcus granulosus	receptor type guanylyl cyclase	0.0063	0.0037	0.0039
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0063	0.0037	0.0039
Echinococcus granulosus	insulin receptor	0.0063	0.0037	0.0039
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0186	0.0248	0.1585
Entamoeba histolytica	hypothetical protein	0.0088	0.0079	0.0274
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0063	0.0037	0.0032
Echinococcus granulosus	integrin linked protein kinase	0.0063	0.0037	0.0039
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0186	0.0248	0.1585
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0063	0.0037	0.0025
Entamoeba histolytica	hypothetical protein	0.0955	0.1562	1
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0079	0.0506
Echinococcus granulosus	G protein coupled receptor kinase 1	0.3558	0.6016	0.7188
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Brugia malayi	Cadps2 protein	0.0088	0.0079	0.0074
Trypanosoma cruzi	hypothetical protein	0.0088	0.0079	0.5099
Schistosoma mansoni	hypothetical protein	0.0088	0.0079	0.0067
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0063	0.0037	0.0039
Trypanosoma cruzi	hypothetical protein	0.0088	0.0079	0.5099
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0088	0.0079	0.0274
Echinococcus granulosus	beta 1 syntrophin	0.0088	0.0079	0.0089
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0088	0.0079	0.0074
Loa Loa (eye worm)	TK/CSK protein kinase	0.0063	0.0037	0.0032
Loa Loa (eye worm)	TK/EPH protein kinase	0.0063	0.0037	0.0032
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0088	0.0079	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0037	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0955	0.1562	0.1558
Trichomonas vaginalis	conserved hypothetical protein	0.0186	0.0248	0.1585
Loa Loa (eye worm)	TK/FER protein kinase	0.0063	0.0037	0.0032
Schistosoma mansoni	syntrophin	0.0088	0.0079	0.0067
Brugia malayi	Uncoordinated protein 104	0.0088	0.0079	0.0074
Trichomonas vaginalis	conserved hypothetical protein	0.0955	0.1562	1
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0079	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0079	0.0074
Entamoeba histolytica	protein kinase domain containing protein	0.0249	0.0356	0.2088
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0063	0.0037	0.0039
Brugia malayi	serine/threonine protein kinase 6	0.0087	0.0078	0.0073
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0037	0.0238
Echinococcus multilocularis	protein kinase	0.0063	0.0037	0.0039
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Echinococcus granulosus	aurora kinase A	0.0087	0.0078	0.0088
Trichomonas vaginalis	protein kinase atn1, putative	0.0063	0.0037	0.0238
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0079	0.0074
Loa Loa (eye worm)	TK protein kinase	0.0063	0.0037	0.0032
Trichomonas vaginalis	centaurin beta, putative	0.0088	0.0079	0.0506
Trypanosoma cruzi	aurora B kinase, putative	0.0087	0.0078	0.5029
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Onchocerca volvulus		0.0088	0.0079	0.026
Entamoeba histolytica	protein kinase domain containing protein	0.0087	0.0078	0.027
Schistosoma mansoni	hypothetical protein	0.0425	0.0656	0.0645
Brugia malayi	Plekhf2 protein	0.0088	0.0079	0.0074
Echinococcus granulosus	tyrosine protein kinase	0.0063	0.0037	0.0039
Echinococcus multilocularis	activin receptor type	0.0087	0.0077	0.0087
Onchocerca volvulus		0.0088	0.0079	0.026
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0063	0.0037	0.0032
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.4933	0.8367	0.8366
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0063	0.0037	0.0039
Loa Loa (eye worm)	Plekhf2 protein	0.0088	0.0079	0.0074
Trichomonas vaginalis	kinesin light chain, putative	0.0088	0.0079	0.0506
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0088	0.0079	0.5099
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0117	0.0129	0.0148
Schistosoma mansoni	protein kinase	0.0063	0.0037	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0079	0.0506
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Brugia malayi	PH domain containing protein	0.0088	0.0079	0.0074
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0063	0.0037	0.0039
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0087	0.0077	0.4901
Schistosoma mansoni	serine/threonine protein kinase	0.0063	0.0037	0.0025
Echinococcus granulosus	activin receptor type	0.0087	0.0077	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0079	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0088	0.0079	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0955	0.1562	0.1558
Brugia malayi	Probable exocyst complex component Sec5	0.0186	0.0248	0.0243
Schistosoma mansoni	protein kinase	0.0063	0.0037	0.0025
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Brugia malayi	Pleckstrin Homology Domain	0.0088	0.0079	0.0074
Echinococcus multilocularis	regulator of G protein signaling 7	0.0955	0.1562	0.1862
Toxoplasma gondii	aurora kinase	0.0087	0.0078	0.5029
Brugia malayi	SH2 domain containing protein	0.0063	0.0037	0.0032
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0063	0.0037	0.0039
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0955	0.1562	1
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Schistosoma mansoni	protein kinase	0.0063	0.0037	0.0025
Brugia malayi	PH domain containing protein	0.0088	0.0079	0.0074
Entamoeba histolytica	cell surface protease gp63, putative	0.0186	0.0248	0.138
Echinococcus multilocularis	oxysterol binding protein 9	0.0088	0.0079	0.0089
Schistosoma mansoni	protein kinase	0.0063	0.0037	0.0025
Brugia malayi	ephrin receptor 1 precursor	0.0063	0.0037	0.0032
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0111	0.0119	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0063	0.0037	0.0039
Loa Loa (eye worm)	rho-GTPase-activating	0.0088	0.0079	0.0074
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0111	0.0119	0.0538
Trichomonas vaginalis	protein transport protein sec7, putative	0.0088	0.0079	0.0506
Onchocerca volvulus		0.0425	0.0656	0.3851
Echinococcus multilocularis	expressed protein	0.0955	0.1562	0.1862
Trypanosoma cruzi	Protein kinase B	0.0111	0.0119	1
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0087	0.0078	0.5029
Brugia malayi	SH2 domain containing protein	0.0063	0.0037	0.0032
Toxoplasma gondii	protein kinase domain-containing protein	0.0111	0.0119	1
Brugia malayi	Oxysterol-binding protein	0.0088	0.0079	0.0074
Echinococcus multilocularis	regulator of G protein signaling 3	0.0955	0.1562	0.1862
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0111	0.0119	0.0763
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0088	0.0079	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Brugia malayi	hypothetical protein	0.0425	0.0656	0.0651
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Echinococcus granulosus	expressed protein	0.0955	0.1562	0.1862
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0063	0.0037	0.0032
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0063	0.0037	0.0039
Brugia malayi	hypothetical protein	0.0955	0.1562	0.1558
Schistosoma mansoni	hypothetical protein	0.0063	0.0037	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Entamoeba histolytica	protein kinase, putative	0.0111	0.0119	0.0538
Entamoeba histolytica	PH domain containing protein	0.0088	0.0079	0.0274
Echinococcus multilocularis	axis inhibition protein axin	0.0955	0.1562	0.1862
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0063	0.0037	0.0039
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0063	0.0037	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0138	0.0133
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Schistosoma mansoni	vav2	0.0088	0.0079	0.0067
Brugia malayi	Variant SH3 domain containing protein	0.0088	0.0079	0.0074
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0111	0.0119	1
Onchocerca volvulus	Putative zinc finger protein	0.0088	0.0079	0.026
Schistosoma mansoni	dynamin	0.0088	0.0079	0.0067
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Schistosoma mansoni	hypothetical protein	0.0578	0.0917	0.0906
Schistosoma mansoni	axis inhibition protein axin	0.0955	0.1562	0.1552
Schistosoma mansoni	goodpasture antigen-binding protein	0.0088	0.0079	0.0067
Schistosoma mansoni	ephrin receptor	0.0069	0.0046	0.0035
Trypanosoma brucei	aurora B kinase	0.0087	0.0078	0.5029
Loa Loa (eye worm)	TK protein kinase	0.0063	0.0037	0.0032
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0063	0.0037	0.0039
Brugia malayi	TBC domain containing protein	0.0088	0.0079	0.0074
Echinococcus multilocularis	tyrosine protein kinase csk	0.0063	0.0037	0.0039
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Echinococcus granulosus	semaphorin 1A	0.0425	0.0656	0.0778
Loa Loa (eye worm)	TK protein kinase	0.0063	0.0037	0.0032
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0063	0.0037	0.0032
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0955	0.1562	0.1862
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Brugia malayi	Dynamin	0.0088	0.0079	0.0074
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Echinococcus multilocularis	epidermal growth factor receptor	0.0063	0.0037	0.0039
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Loa Loa (eye worm)	TK protein kinase	0.0063	0.0037	0.0032
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0088	0.0079	0.0274
Trypanosoma cruzi	PH domain containing protein, putative	0.0088	0.0079	0.5099
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0063	0.0037	0.0039
Brugia malayi	MAX-1A	0.0088	0.0079	0.0074
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0117	0.0129	0.0148
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0186	0.0248	0.1585
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0037	0.0238
Schistosoma mansoni	nephrin	0.0122	0.0138	0.0127
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0088	0.0079	0.0274
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0063	0.0037	0.0039
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0088	0.0079	0.0067
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Plasmodium vivax	hypothetical protein, conserved	0.0088	0.0079	0.5099
Loa Loa (eye worm)	AUR protein kinase	0.0087	0.0078	0.0073
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Echinococcus granulosus	epidermal growth factor receptor	0.0063	0.0037	0.0039
Schistosoma mansoni	protein kinase	0.0063	0.0037	0.0025
Entamoeba histolytica	protein kinase, putative	0.0111	0.0119	0.0538
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0063	0.0037	0.0039
Echinococcus multilocularis	plexin a4	0.1188	0.1962	0.2341
Entamoeba histolytica	protein kinase domain containing protein	0.0087	0.0077	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0079	0.0074
Echinococcus granulosus	transcription factor collier	0.0186	0.0248	0.029
Trichomonas vaginalis	conserved hypothetical protein	0.0955	0.1562	1
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0087	0.0078	0.027
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0063	0.0037	0.0039
Echinococcus granulosus	defective proboscis extension response	0.0117	0.0129	0.0148
Loa Loa (eye worm)	TK/FER protein kinase	0.0063	0.0037	0.0032
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0037	0.0238
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0037	0.0238
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0111	0.0119	1
Brugia malayi	serine/threonine kinase 12	0.0087	0.0078	0.0073
Brugia malayi	hypothetical protein	0.0425	0.0656	0.0651
Schistosoma mansoni	plexin	0.0578	0.0917	0.0906
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0088	0.0079	0.0274
Brugia malayi	Sema domain containing protein	0.0425	0.0656	0.0651
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0955	0.1562	0.1558
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Echinococcus granulosus	regulator of G protein signaling 7	0.0955	0.1562	0.1862
Echinococcus granulosus	calcium dependent secretion activator 1	0.0088	0.0079	0.0089
Brugia malayi	Dynamin	0.0088	0.0079	0.0074
Schistosoma mansoni	serine/threonine protein kinase	0.4513	0.7649	0.7646
Echinococcus multilocularis	aurora kinase A	0.0087	0.0078	0.0088
Echinococcus granulosus	oxysterol binding protein 3	0.0088	0.0079	0.0089
Brugia malayi	PXA domain containing protein	0.0955	0.1562	0.1558
Echinococcus multilocularis	oxysterol binding protein 3	0.0088	0.0079	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0578	0.0917	0.0913
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0111	0.0119	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0425	0.0656	0.0651
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0063	0.0037	0.0039
Echinococcus granulosus	beta-adrenergic receptor kinase	0.4513	0.7649	0.9141
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0063	0.0037	0.0039
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0087	0.0077	0.4901
Echinococcus granulosus	tyrosine protein kinase Blk	0.0063	0.0037	0.0039
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0955	0.1562	0.1552
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0063	0.0037	0.0039
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0955	0.1562	0.1552
Schistosoma mansoni	protein tyrosine kinase	0.0063	0.0037	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Plasmodium vivax	PH domain containing protein	0.0088	0.0079	0.5099
Brugia malayi	PH domain containing protein	0.0088	0.0079	0.0074
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0063	0.0037	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0248	0.0243
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Loa Loa (eye worm)	TK/FAK protein kinase	0.0063	0.0037	0.0032
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0087	0.0077	0.0087
Echinococcus granulosus	activated cdc42 kinase 1	0.0063	0.0037	0.0039
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0088	0.0079	0.0089
Echinococcus multilocularis	protein tyrosine kinase	0.0063	0.0037	0.0039
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0111	0.0119	0.0114
Trichomonas vaginalis	conserved hypothetical protein	0.0955	0.1562	1
Leishmania major	protein kinase, putative	0.0111	0.0119	1
Echinococcus multilocularis	pdz domain containing protein	0.0088	0.0079	0.0089
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0063	0.0037	0.0039
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0063	0.0037	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0129	0.0124
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0063	0.0037	0.0039
Loa Loa (eye worm)	TK protein kinase	0.0063	0.0037	0.0032
Loa Loa (eye worm)	TK protein kinase	0.0063	0.0037	0.0032
Echinococcus granulosus	axis inhibition protein axin	0.0955	0.1562	0.1862
Echinococcus granulosus	regulator of G protein signaling 3	0.0955	0.1562	0.1862
Echinococcus granulosus	protein tyrosine kinase	0.0063	0.0037	0.0039
Brugia malayi	plexin A	0.1188	0.1962	0.1958
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0111	0.0119	1
Leishmania major	folate/biopterin transporter, putative	0.0111	0.0119	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0111	0.0119	0.0107
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0063	0.0037	0.0039
Schistosoma mansoni	hypothetical protein	0.0088	0.0079	0.0067
Trichomonas vaginalis	TKL family protein kinase	0.0063	0.0037	0.0238
Brugia malayi	Immunoglobulin I-set domain containing protein	0.018	0.0237	0.0232
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0088	0.0079	0.0074
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0063	0.0037	0.0039
Trichomonas vaginalis	STE family protein kinase	0.0063	0.0037	0.0238
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0088	0.0079	0.5099
Loa Loa (eye worm)	TK/ALK protein kinase	0.0326	0.0486	0.0482
Toxoplasma gondii	hypothetical protein	0.0088	0.0079	0.5099
Echinococcus granulosus	GRB2 associated binding protein 3	0.0088	0.0079	0.0089
Loa Loa (eye worm)	TK/FER protein kinase	0.0063	0.0037	0.0032
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0088	0.0079	0.0089
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0955	0.1562	0.1558
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0063	0.0037	0.0039
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0063	0.0037	0.0032
Entamoeba histolytica	hypothetical protein	0.0111	0.0119	0.0538
Loa Loa (eye worm)	sema domain-containing protein	0.0425	0.0656	0.0651
Trichomonas vaginalis	centaurin alpha, putative	0.0088	0.0079	0.0506
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0063	0.0037	0.0039
Giardia lamblia	Aurora kinase	0.0087	0.0078	1
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Trichomonas vaginalis	AGC family protein kinase	0.0111	0.0119	0.0763
Loa Loa (eye worm)	TK protein kinase	0.0063	0.0037	0.0032
Leishmania major	protein kinase, putative	0.0087	0.0078	0.5029
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0063	0.0037	0.0238
Brugia malayi	regulator of G-protein signaling egl-10	0.0955	0.1562	0.1558
Echinococcus granulosus	tyrosine kinase	0.0063	0.0037	0.0039
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0122	0.0138	0.0133
Brugia malayi	Protein kinase domain containing protein	0.0063	0.0037	0.0032
Entamoeba histolytica	protein kinase, putative	0.0111	0.0119	0.0538
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0087	0.0078	0.027
Onchocerca volvulus		0.1002	0.1644	1
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0111	0.0119	1
Schistosoma mansoni	tyrosine protein kinase	0.0063	0.0037	0.0025
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0069	0.0046	0.005
Schistosoma mansoni	serine/threonine protein kinase	0.4513	0.7649	0.7646
Schistosoma mansoni	protein kinase	0.0087	0.0077	0.0066
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0087	0.0077	0.4901
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0079	0.0506
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0111	0.0119	1
Schistosoma mansoni	tyrosine kinase	0.0063	0.0037	0.0025
Brugia malayi	Guanylyl cyclase protein 23	0.0063	0.0037	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0037	0.0032
Brugia malayi	PXA domain containing protein	0.0955	0.1562	0.1558
Entamoeba histolytica	hypothetical protein	0.0088	0.0079	0.0274
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0063	0.0037	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0079	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0248	0.0243
Echinococcus multilocularis	semaphorin 5B	0.0425	0.0656	0.0778

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 6.5	Antagonist activity at human recombinant CXCR3 receptor expressed in CHO-K1 cells assessed as human IP10-induced calcium flux by FLIPR assay	ChEMBL.	19014886

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL479828

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 979227