TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 536.783 | Formula: C32H56O6
H donors: 4 H acceptors: 5 LogP: 6.57 Rotable bonds: 5
Rule of 5 violations (Lipinski): 2
SMILES: C=C/C=C\[C@@H]([C@@H]([C@H]([C@H]1CC[C@H](C)C[C@H](C)[C@@H](O)[C@@H](C)/C=C\[C@H](C[C@@H]([C@@H](CCCCC(=O)O1)C)O)O)C)O)C
InChi: 1S/C32H56O6/c1-8-9-12-23(4)32(37)26(7)29-18-15-21(2)19-25(6)31(36)24(5)16-17-27(33)20-28(34)22(3)13-10-11-14-30(35)38-29/h8-9,12,16-17,21-29,31-34,36-37H,1,10-11,13-15,18-20H2,2-7H3/b12-9-,17-16-/t21-,22+,23-,24-,25-,26-,27+,28-,29+,31-,32-/m0/s1
InChiKey: MSJDZYJSVXFWKD-GZLSDFCXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	DCC interacting protein 13 beta	0.0074	0.0071	0.0078
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0059	0.0041	0.0043
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0059	0.0041	0.0043
Echinococcus granulosus	kinase suppressor of Ras 1	0.0059	0.0041	0.0043
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0079	0.0082	0.0091
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0059	0.0041	0.0036
Entamoeba histolytica	PH domain containing protein	0.0074	0.0071	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0071	0.0066
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0059	0.0041	0.0043
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.4141	0.8366	0.8365
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0071	0.0457
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0059	0.0041	0.0043
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0093	0.0111	1
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Brugia malayi	hypothetical protein	0.0393	0.0723	0.0718
Echinococcus granulosus	tyrosine protein kinase HCK	0.0059	0.0041	0.0043
Schistosoma mansoni	ephrin receptor	0.0064	0.0052	0.0038
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Schistosoma mansoni	serine/threonine-protein kinase	0.0093	0.0111	0.0098
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0059	0.0041	0.0043
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0059	0.0041	0.0043
Trichomonas vaginalis	STE family protein kinase	0.0059	0.0041	0.0266
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0059	0.0041	0.0043
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0079	0.0082	0.5754
Trypanosoma cruzi	PH domain containing protein, putative	0.0074	0.0071	0.4246
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0059	0.0041	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0801	0.1555	0.1551
Entamoeba histolytica	hypothetical protein	0.0801	0.1555	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0059	0.0041	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0152	0.0147
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Echinococcus granulosus	oxysterol binding protein 9	0.0074	0.0071	0.0078
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0059	0.0041	0.0043
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0059	0.0041	0.0043
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0172	0.0272	0.1751
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.0071	0.0197
Schistosoma mansoni	hypothetical protein	0.0074	0.0071	0.0058
Brugia malayi	IPT/TIG domain containing protein	0.0172	0.0272	0.0267
Echinococcus multilocularis	protein kinase	0.0059	0.0041	0.0043
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0074	0.0071	0.4246
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Leishmania major	hypothetical protein, conserved	0.0074	0.0071	0.4246
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0059	0.0041	0.0028
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0393	0.0723	0.0718
Echinococcus multilocularis	tyrosine kinase	0.0059	0.0041	0.0043
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0.0272	0.1751
Echinococcus granulosus	Regulator of G protein signaling 20	0.0801	0.1555	0.1854
Schistosoma mansoni	regulator of G protein signaling	0.0801	0.1555	0.1544
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0059	0.0041	0.0043
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0074	0.0071	0.0078
Echinococcus granulosus	activated cdc42 kinase 1	0.0059	0.0041	0.0043
Brugia malayi	Protein kinase domain containing protein	0.0093	0.0111	0.0106
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.4141	0.8366	0.8365
Echinococcus multilocularis	axis inhibition protein axin	0.0801	0.1555	0.1854
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0081	0.0086	0.0552
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Loa Loa (eye worm)	PXA domain-containing protein	0.0801	0.1555	0.1551
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0081	0.0086	0.0294
Brugia malayi	A-kinase anchor protein 10, precursor	0.0801	0.1555	0.1551
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0801	0.1555	0.1854
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0081	0.0086	0.6361
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0071	0.0457
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0093	0.0111	1
Echinococcus granulosus	tyrosine kinase	0.0059	0.0041	0.0043
Trichomonas vaginalis	protein transport protein sec7, putative	0.0074	0.0071	0.0457
Entamoeba histolytica	hypothetical protein	0.0093	0.0111	0.0463
Onchocerca volvulus	Putative zinc finger protein	0.0074	0.0071	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0393	0.0723	0.0718
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0059	0.0041	0.0028
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0059	0.0041	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0071	0.0066
Toxoplasma gondii	hypothetical protein	0.0074	0.0071	0.4246
Schistosoma mansoni	dynamin	0.0074	0.0071	0.0058
Onchocerca volvulus		0.0393	0.0723	0.3849
Brugia malayi	Furin-like cysteine rich region family protein	0.0059	0.0041	0.0036
Schistosoma mansoni	goodpasture antigen-binding protein	0.0074	0.0071	0.0058
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0041	0.0036
Schistosoma mansoni	goodpasture antigen-binding protein	0.0074	0.0071	0.0058
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Schistosoma mansoni	syntrophin	0.0074	0.0071	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0071	0.0066
Brugia malayi	PH domain containing protein	0.0074	0.0071	0.0066
Schistosoma mansoni	hypothetical protein	0.0074	0.0071	0.0058
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0074	0.0071	0.0078
Brugia malayi	TBC domain containing protein	0.0074	0.0071	0.0066
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Trichomonas vaginalis	hypothetical protein	0.0074	0.0071	0.0457
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0059	0.0041	0.0028
Brugia malayi	Oxysterol binding protein	0.0074	0.0071	0.0066
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0393	0.0723	0.0718
Entamoeba histolytica	p21-activated kinase	0.0093	0.0111	0.0463
Entamoeba histolytica	hypothetical protein	0.0801	0.1555	1
Brugia malayi	hypothetical protein	0.0074	0.0071	0.0066
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0074	0.0071	0.0078
Schistosoma mansoni	serine/threonine protein kinase	0.3788	0.7647	0.7644
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Trypanosoma brucei	PH domain containing protein, putative	0.0074	0.0071	0.4246
Brugia malayi	hypothetical protein	0.0118	0.0162	0.0157
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Echinococcus granulosus	Pleckstrin y	0.0074	0.0071	0.0078
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Trypanosoma cruzi	aurora B kinase, putative	0.0081	0.0086	0.6361
Echinococcus granulosus	transcription factor collier	0.0172	0.0272	0.0319
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Trypanosoma cruzi	hypothetical protein	0.0074	0.0071	0.4246
Echinococcus granulosus	tyrosine protein kinase shark	0.0059	0.0041	0.0043
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0093	0.0111	1
Entamoeba histolytica	protein kinase, putative	0.0081	0.0086	0.0294
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0.0272	0.1751
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0074	0.0071	0.4246
Brugia malayi	Protein kinase domain containing protein	0.0306	0.0544	0.0539
Echinococcus granulosus	tyrosine protein kinase Blk	0.0059	0.0041	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0059	0.0041	0.0036
Entamoeba histolytica	protein kinase, putative	0.0093	0.0111	0.0463
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0071	0.0066
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0064	0.0052	0.0055
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0172	0.0272	0.1751
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Entamoeba histolytica	hypothetical protein	0.0172	0.0272	0.1526
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0074	0.0071	0.0457
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0041	0.0036
Leishmania major	serine/threonine-protein kinase a, putative	0.0093	0.0111	1
Echinococcus multilocularis	neuroglian	0.0113	0.0152	0.0175
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0801	0.1555	0.1544
Trypanosoma cruzi	PH domain containing protein, putative	0.0074	0.0071	0.4246
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Trichomonas vaginalis	centaurin/arf, putative	0.0074	0.0071	0.0457
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0172	0.0272	0.1751
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0059	0.0041	0.0028
Echinococcus granulosus	aurora kinase A	0.0081	0.0086	0.0096
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0059	0.0041	0.0043
Schistosoma mansoni	growth factor receptor-bound protein	0.0074	0.0071	0.0058
Echinococcus multilocularis	tyrosine protein kinase csk	0.0059	0.0041	0.0043
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Schistosoma mansoni	semaphorin 5-related	0.0393	0.0723	0.071
Echinococcus multilocularis	cytohesin 1	0.0074	0.0071	0.0078
Schistosoma mansoni	protein kinase	0.0059	0.0041	0.0028
Echinococcus multilocularis	regulator of G protein signaling	0.0801	0.1555	0.1854
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Entamoeba histolytica	tyrosin kinase, putative	0.0231	0.0393	0.232
Trypanosoma brucei	protein kinase, putative	0.0079	0.0082	0.5754
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0059	0.0041	0.0043
Loa Loa (eye worm)	TK/INSR protein kinase	0.0059	0.0041	0.0036
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0071	0.0457
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Echinococcus multilocularis	tyrosine kinase	0.0059	0.0041	0.0043
Schistosoma mansoni	hypothetical protein	0.0074	0.0071	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0071	0.0066
Echinococcus granulosus	GRB2 associated binding protein 3	0.0074	0.0071	0.0078
Brugia malayi	protein-tyrosine kinase	0.0059	0.0041	0.0036
Echinococcus granulosus	oxysterol binding protein 3	0.0074	0.0071	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Echinococcus multilocularis	pdz domain containing protein	0.0074	0.0071	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0927	0.1812	0.1807
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Brugia malayi	PH domain containing protein	0.0074	0.0071	0.0066
Echinococcus granulosus	ephrin type A receptor 4 A	0.0059	0.0041	0.0043
Schistosoma mansoni	hypothetical protein	0.0393	0.0723	0.071
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0093	0.0111	1
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0074	0.0071	0.0078
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0059	0.0041	0.0043
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0093	0.0111	0.0463
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0093	0.0111	1
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0093	0.0111	1
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0074	0.0071	0.0058
Echinococcus granulosus	twitchin	0.0133	0.0192	0.0223
Echinococcus granulosus	regulator of G protein signaling 3	0.0801	0.1555	0.1854
Schistosoma mansoni	vav2	0.0074	0.0071	0.0058
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0093	0.0111	1
Brugia malayi	probable spectrin beta chain	0.0074	0.0071	0.0066
Schistosoma mansoni	centaurin alpha	0.0074	0.0071	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0071	0.0066
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0059	0.0041	0.0028
Echinococcus granulosus	epidermal growth factor receptor	0.0059	0.0041	0.0043
Echinococcus granulosus	tyrosine protein kinase Srms	0.0059	0.0041	0.0043
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Loa Loa (eye worm)	SRC-1	0.0059	0.0041	0.0036
Echinococcus granulosus	beta 1 syntrophin	0.0074	0.0071	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0071	0.0457
Onchocerca volvulus		0.0074	0.0071	0.0168
Echinococcus multilocularis	beta 1 syntrophin	0.0074	0.0071	0.0078
Brugia malayi	Cytohesin 3	0.0074	0.0071	0.0066
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0059	0.0041	0.0036
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0074	0.0071	0.4246
Schistosoma mansoni	plexin	0.0927	0.1812	0.1801
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Echinococcus multilocularis	tyrosine protein kinase csk	0.0059	0.0041	0.0043
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0074	0.0071	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0093	0.0111	0.0716
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Echinococcus multilocularis	protein kinase	0.0059	0.0041	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0071	0.0457
Trichomonas vaginalis	kinesin light chain, putative	0.0074	0.0071	0.0457
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0059	0.0041	0.0043
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0059	0.0041	0.0043
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Schistosoma mansoni	hypothetical protein	0.0393	0.0723	0.071
Trypanosoma brucei	protein kinase, putative	0.0093	0.0111	1
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0074	0.0071	0.0078
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0074	0.0071	0.4246
Schistosoma mansoni	regulator of G protein signaling	0.0801	0.1555	0.1544
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.0071	0.0197
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0074	0.0071	0.4246
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0059	0.0041	0.0036
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0093	0.0111	1
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Entamoeba histolytica	protein kinase, putative	0.0093	0.0111	0.0463
Schistosoma mansoni	protein kinase	0.0079	0.0082	0.0068
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0079	0.0082	0.5754
Brugia malayi	Syntrophin-1	0.0074	0.0071	0.0066
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0074	0.0071	0.0197
Loa Loa (eye worm)	sema domain-containing protein	0.0393	0.0723	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0071	0.0066
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0071	0.0457
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0059	0.0041	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0172	0.0272	0.0267
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0093	0.0111	1
Brugia malayi	hypothetical protein	0.0393	0.0723	0.0718
Brugia malayi	regulator of G-protein signaling egl-10	0.0801	0.1555	0.1551
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Echinococcus multilocularis	exocyst complex component 2	0.0172	0.0272	0.0319
Echinococcus granulosus	tyrosine protein kinase csk	0.0059	0.0041	0.0043
Trichomonas vaginalis	centaurin gamma, putative	0.0074	0.0071	0.0457
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0172	0.0272	0.0267
Brugia malayi	PXA domain containing protein	0.0801	0.1555	0.1551
Loa Loa (eye worm)	hypothetical protein	0.0801	0.1555	0.1551
Loa Loa (eye worm)	AUR protein kinase	0.0081	0.0086	0.008
Schistosoma mansoni	zinc finger protein	0.0074	0.0071	0.0058
Echinococcus multilocularis	FL cytokine receptor	0.0059	0.0041	0.0043
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0059	0.0041	0.0043
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0059	0.0041	0.0043
Echinococcus multilocularis	c src tyrosine kinase	0.0059	0.0041	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0801	0.1555	0.1551
Brugia malayi	MAX-1A	0.0074	0.0071	0.0066
Loa Loa (eye worm)	PH domain-containing protein	0.0074	0.0071	0.0066
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0059	0.0041	0.0036
Brugia malayi	PH domain containing protein	0.0074	0.0071	0.0066
Toxoplasma gondii	AtPH1 family protein	0.0074	0.0071	0.4246
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0074	0.0071	0.0066
Toxoplasma gondii	protein kinase domain-containing protein	0.0093	0.0111	1
Brugia malayi	PH domain containing protein	0.0074	0.0071	0.0066
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Echinococcus granulosus	integrin linked protein kinase	0.0059	0.0041	0.0043
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Entamoeba histolytica	hypothetical protein, conserved	0.0074	0.0071	0.0197
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0074	0.0071	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0113	0.0152	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0071	0.0066
Giardia lamblia	Aurora kinase	0.0081	0.0086	1
Schistosoma mansoni	protein kinase	0.0079	0.0082	0.0068
Brugia malayi	Raf kinase	0.0059	0.0041	0.0036
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0059	0.0041	0.0036
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0074	0.0071	0.0078
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Schistosoma mansoni	serine/threonine protein kinase	0.0059	0.0041	0.0028
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0074	0.0071	0.0078
Echinococcus granulosus	tyrosine protein kinase csk	0.0059	0.0041	0.0043
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Echinococcus multilocularis	dynamin 1	0.0074	0.0071	0.0078
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Entamoeba histolytica	protein kinase, putative	0.0093	0.0111	0.0463
Loa Loa (eye worm)	oxysterol binding protein	0.0074	0.0071	0.0066
Leishmania major	folate/biopterin transporter, putative	0.0093	0.0111	1
Loa Loa (eye worm)	uncoordinated protein 104	0.0074	0.0071	0.0066
Loa Loa (eye worm)	TK/EPH protein kinase	0.0059	0.0041	0.0036
Echinococcus multilocularis	oxysterol binding protein 3	0.0074	0.0071	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Brugia malayi	serine/threonine-protein kinase 6	0.0081	0.0086	0.008
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0071	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0172	0.0272	0.0267
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0074	0.0071	0.0078
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0152	0.0147
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Echinococcus multilocularis	Immunoglobulin	0.0113	0.0152	0.0175
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Echinococcus granulosus	calcium dependent secretion activator 1	0.0074	0.0071	0.0078
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0074	0.0071	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0801	0.1555	1
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Brugia malayi	PXA domain containing protein	0.0801	0.1555	0.1551
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0059	0.0041	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Echinococcus multilocularis	Immunoglobulin	0.0113	0.0152	0.0175
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0059	0.0041	0.0036
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0079	0.0082	0.0091
Echinococcus granulosus	pleckstrin y domain containing family A	0.0074	0.0071	0.0078
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0059	0.0041	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0152	0.0147
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0059	0.0041	0.0036
Brugia malayi	Oxysterol-binding protein	0.0074	0.0071	0.0066
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0074	0.0071	0.0078
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0071	0.0066
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0059	0.0041	0.0043
Echinococcus multilocularis	transcription factor collier	0.0172	0.0272	0.0319
Brugia malayi	Receptor family ligand binding region containing protein	0.0059	0.0041	0.0036
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0059	0.0041	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Loa Loa (eye worm)	hypothetical protein	0.0393	0.0723	0.0718
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Echinococcus granulosus	semaphorin 1A	0.0393	0.0723	0.0858
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0059	0.0041	0.0043
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Echinococcus granulosus	myotubularin protein 13	0.0074	0.0071	0.0078
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0059	0.0041	0.0266
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0059	0.0041	0.0043
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Onchocerca volvulus	outspread protein homolog	0.0074	0.0071	0.0168
Echinococcus multilocularis	epidermal growth factor receptor	0.0059	0.0041	0.0043
Entamoeba histolytica	hypothetical protein	0.0074	0.0071	0.0197
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0074	0.0071	0.0457
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0071	0.0457
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Echinococcus multilocularis	tyrosine protein kinase shark	0.0059	0.0041	0.0043
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0071	0.0457
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0059	0.0041	0.0043
Trichomonas vaginalis	TK family protein kinase	0.0059	0.0041	0.0266
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Schistosoma mansoni	vesicular amine transporter	0.0116	0.0158	0.0144
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0059	0.0041	0.0043
Echinococcus multilocularis	aurora kinase A	0.0081	0.0086	0.0096
Echinococcus granulosus	dynamin 1	0.0074	0.0071	0.0078
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0059	0.0041	0.0266
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0074	0.0071	0.0078
Trypanosoma cruzi	hypothetical protein	0.0074	0.0071	0.4246
Trichomonas vaginalis	centaurin/arf, putative	0.0074	0.0071	0.0457
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0074	0.0071	0.0197
Echinococcus multilocularis	Pleckstrin y	0.0074	0.0071	0.0078
Entamoeba histolytica	hypothetical protein	0.0093	0.0111	0.0463
Loa Loa (eye worm)	TK/Met protein kinase	0.0059	0.0041	0.0036
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Echinococcus granulosus	epidermal growth factor receptor	0.0059	0.0041	0.0043
Entamoeba histolytica	hypothetical protein	0.0172	0.0272	0.1526
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0074	0.0071	0.0078
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0074	0.0071	0.0078
Echinococcus granulosus	beta-adrenergic receptor kinase	0.3788	0.7647	0.914
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Echinococcus granulosus	protein kinase	0.0059	0.0041	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0074	0.0071	0.0066
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0064	0.0052	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0071	0.0066
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0074	0.0071	0.4246
Schistosoma mansoni	protein tyrosine kinase	0.0059	0.0041	0.0028
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0059	0.0041	0.0043
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Echinococcus granulosus	tyrosine kinase	0.0059	0.0041	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0071	0.0066
Echinococcus multilocularis	regulator of G protein signaling 3	0.0801	0.1555	0.1854
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0071	0.0066
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.0071	0.0197
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0074	0.0071	0.0066
Trypanosoma brucei	aurora B kinase	0.0081	0.0086	0.6361
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0113	0.0152	0.0139
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0059	0.0041	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0172	0.0272	0.1751
Entamoeba histolytica	protein kinase, putative	0.0093	0.0111	0.0463
Brugia malayi	Plekhf2 protein	0.0074	0.0071	0.0066
Echinococcus multilocularis	integrin linked protein kinase	0.0059	0.0041	0.0043
Echinococcus multilocularis	rac serine:threonine kinase	0.0093	0.0111	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0217	0.0364	0.0358
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0041	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0074	0.0071	0.0066
Brugia malayi	ephrin receptor 1 precursor	0.0059	0.0041	0.0036
Brugia malayi	Plexin repeat family protein	0.0927	0.1812	0.1807
Brugia malayi	Tyrosine-protein kinase abl-1	0.0059	0.0041	0.0036
Trichomonas vaginalis	CAMK family protein kinase	0.0059	0.0041	0.0266
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0093	0.0111	1
Brugia malayi	SH2 domain containing protein	0.0059	0.0041	0.0036
Brugia malayi	PH domain containing protein	0.0074	0.0071	0.0066
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0.0272	0.1751
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Schistosoma mansoni	serine/threonine protein kinase	0.0059	0.0041	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0801	0.1555	1
Brugia malayi	PH domain containing protein	0.0074	0.0071	0.0066
Echinococcus granulosus	raf serine:threonine protein kinase	0.0059	0.0041	0.0043
Echinococcus granulosus	receptor type guanylyl cyclase	0.0059	0.0041	0.0043
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0801	0.1555	0.1544
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Trypanosoma cruzi	NIMA-related kinase, putative	0.0093	0.0111	1
Loa Loa (eye worm)	AUR protein kinase	0.0081	0.0086	0.008
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Echinococcus granulosus	neuroglian	0.0113	0.0152	0.0175
Echinococcus granulosus	pdz domain containing protein	0.0074	0.0071	0.0078
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0059	0.0041	0.0043
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0093	0.0111	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Loa Loa (eye worm)	RGS-3 protein	0.0801	0.1555	0.1551
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0059	0.0041	0.0043
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0059	0.0041	0.0043
Toxoplasma gondii	hypothetical protein	0.0074	0.0071	0.4246
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0041	0.0036
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0118	0.0162	0.0157
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0081	0.0086	0.0294
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0081	0.0086	0.6361
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0059	0.0041	0.0028
Echinococcus multilocularis	tyrosine protein kinase	0.0059	0.0041	0.0043
Echinococcus granulosus	regulator of G protein signaling 7	0.0801	0.1555	0.1854
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0059	0.0041	0.0043
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0074	0.0071	0.0168
Entamoeba histolytica	protein kinase, putative	0.0093	0.0111	0.0463
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0071	0.0457
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Echinococcus multilocularis	tyrosine protein kinase csk	0.0059	0.0041	0.0043
Schistosoma mansoni	dynamin	0.0074	0.0071	0.0058
Brugia malayi	hypothetical protein	0.0801	0.1555	0.1551
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0059	0.0041	0.0043
Toxoplasma gondii	aurora kinase	0.0081	0.0086	0.6361
Schistosoma mansoni	cell adhesion molecule	0.0118	0.0162	0.0149
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0074	0.0071	0.0078
Echinococcus multilocularis	roundabout 2	0.0118	0.0162	0.0188
Brugia malayi	Variant SH3 domain containing protein	0.0074	0.0071	0.0066
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0801	0.1555	1
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0074	0.0071	0.0197
Brugia malayi	C-terminal src kinase protein 1	0.0059	0.0041	0.0036
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0074	0.0071	0.4246
Schistosoma mansoni	protein kinase	0.0079	0.0082	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0071	0.0066
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0093	0.0111	1
Echinococcus granulosus	G protein coupled receptor kinase 1	0.2987	0.6013	0.7185
Onchocerca volvulus		0.0074	0.0071	0.0168
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Entamoeba histolytica	protein kinase, putative	0.0093	0.0111	0.0463
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0059	0.0041	0.0043
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0041	0.0036
Brugia malayi	hypothetical protein	0.0059	0.0041	0.0036
Echinococcus multilocularis	heat shock protein 70	0.0059	0.0041	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0071	0.0066
Schistosoma mansoni	hypothetical protein	0.0074	0.0071	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0071	0.0066
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0059	0.0041	0.0043
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0801	0.1555	0.1551
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.4942	1	1
Brugia malayi	hypothetical protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0801	0.1555	1
Echinococcus multilocularis	Pleckstrin y	0.0074	0.0071	0.0078
Entamoeba histolytica	protein kinase , putative	0.0081	0.0086	0.0294
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0081	0.0086	0.0096
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0059	0.0041	0.0043
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0079	0.0082	0.0091
Entamoeba histolytica	hypothetical protein	0.0074	0.0071	0.0197
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0074	0.0071	0.0078
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0074	0.0071	0.0066
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0172	0.0272	0.1751
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0393	0.0723	0.0718
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0059	0.0041	0.0036
Loa Loa (eye worm)	TK/ABL protein kinase	0.0059	0.0041	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Trypanosoma cruzi	hypothetical protein	0.0074	0.0071	0.4246
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0074	0.0071	0.0078
Brugia malayi	plexin A	0.1099	0.2163	0.2159
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0081	0.0086	0.0294
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0801	0.1555	0.1551
Echinococcus multilocularis	plexin a4	0.1099	0.2163	0.2581
Loa Loa (eye worm)	hypothetical protein	0.0172	0.0272	0.0267
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0074	0.0071	0.0066
Loa Loa (eye worm)	AUR protein kinase	0.0081	0.0086	0.008
Echinococcus multilocularis	myotubularin protein 13	0.0074	0.0071	0.0078
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Echinococcus granulosus	tyrosine protein kinase	0.0059	0.0041	0.0043
Onchocerca volvulus		0.0074	0.0071	0.0168
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0074	0.0071	0.0457
Brugia malayi	serine/threonine protein kinase 6	0.0081	0.0086	0.008
Leishmania major	protein kinase, putative	0.0081	0.0086	0.6361
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0071	0.0457
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Schistosoma mansoni	protein kinase	0.0059	0.0041	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0071	0.0457
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0059	0.0041	0.0036
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0093	0.0111	0.0716
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Echinococcus granulosus	activin receptor type	0.0079	0.0082	0.0091
Loa Loa (eye worm)	TK/FAK protein kinase	0.0059	0.0041	0.0036
Plasmodium falciparum	oxysterol-binding protein, putative	0.0074	0.0071	0.4246
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0093	0.0111	1
Plasmodium vivax	hypothetical protein, conserved	0.0074	0.0071	0.4246
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Trypanosoma cruzi	PH domain containing protein, putative	0.0074	0.0071	0.4246
Schistosoma mansoni	protein kinase	0.0059	0.0041	0.0028
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0041	0.0036
Loa Loa (eye worm)	serine/threonine protein kinase	0.0059	0.0041	0.0036
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Entamoeba histolytica	PH domain containing protein	0.0074	0.0071	0.0197
Schistosoma mansoni	ephrin receptor	0.0059	0.0041	0.0028
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Plasmodium vivax	PH domain containing protein	0.0074	0.0071	0.4246
Loa Loa (eye worm)	TK/ROR protein kinase	0.0059	0.0041	0.0036
Echinococcus granulosus	tyrosine protein kinase pr2	0.0059	0.0041	0.0043
Brugia malayi	SRC-1	0.0059	0.0041	0.0036
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0074	0.0071	0.0457
Loa Loa (eye worm)	hypothetical protein	0.0801	0.1555	0.1551
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0059	0.0041	0.0043
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0071	0.0457
Echinococcus multilocularis	Pleckstrin y	0.0074	0.0071	0.0078
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Echinococcus granulosus	Oxysterol binding protein 11	0.0074	0.0071	0.0078
Trypanosoma cruzi	hypothetical protein	0.0074	0.0071	0.4246
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0059	0.0041	0.0043
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0093	0.0111	1
Echinococcus multilocularis	regulator of G protein signaling 7	0.0801	0.1555	0.1854
Loa Loa (eye worm)	TK/RYK protein kinase	0.0059	0.0041	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0074	0.0071	0.0197
Loa Loa (eye worm)	cytohesin 3	0.0074	0.0071	0.0066
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0801	0.1555	0.1854
Loa Loa (eye worm)	sema domain-containing protein	0.0393	0.0723	0.0718
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0.0272	0.1751
Echinococcus multilocularis	semaphorin 5B	0.0393	0.0723	0.0858
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Brugia malayi	Probable exocyst complex component Sec5	0.0172	0.0272	0.0267
Trichomonas vaginalis	centaurin beta, putative	0.0074	0.0071	0.0457
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0059	0.0041	0.0043
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0093	0.0111	1
Schistosoma mansoni	hypothetical protein	0.0059	0.0041	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0071	0.0457
Echinococcus granulosus	roundabout 2	0.0118	0.0162	0.0188
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0074	0.0071	0.0457
Trichomonas vaginalis	conserved hypothetical protein	0.0801	0.1555	1
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0074	0.0071	0.0058
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Entamoeba histolytica	protein kinase domain containing protein	0.0081	0.0086	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0172	0.0272	0.0267
Schistosoma mansoni	tyrosine protein kinase	0.0059	0.0041	0.0028
Echinococcus granulosus	tyrosine protein kinase csk	0.0059	0.0041	0.0043
Trichomonas vaginalis	AGC family protein kinase	0.0081	0.0086	0.0552
Echinococcus multilocularis	epidermal growth factor receptor	0.0059	0.0041	0.0043
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0059	0.0041	0.0036
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0041	0.0036
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0801	0.1555	0.1551
Onchocerca volvulus	Protein melted homolog	0.0074	0.0071	0.0168
Loa Loa (eye worm)	Plekhf2 protein	0.0074	0.0071	0.0066
Brugia malayi	SH2 domain containing protein	0.0059	0.0041	0.0036
Schistosoma mansoni	serine/threonine-protein kinase	0.0093	0.0111	0.0098
Brugia malayi	Dynamin	0.0074	0.0071	0.0066
Schistosoma mansoni	z-protein (S1r protein)	0.0801	0.1555	0.1544
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0059	0.0041	0.0043
Schistosoma mansoni	serine/threonine protein kinase	0.4942	1	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	protein transport protein sec7, putative	0.0074	0.0071	0.0457
Echinococcus granulosus	insulin receptor	0.0059	0.0041	0.0043
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0074	0.0071	0.4246
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0059	0.0041	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0071	0.0457
Echinococcus multilocularis	insulin receptor	0.0059	0.0041	0.0043
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0801	0.1555	1
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Entamoeba histolytica	protein kinase, putative	0.0081	0.0086	0.0294
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0059	0.0041	0.0043
Leishmania major	protein kinase, putative	0.0093	0.0111	1
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Schistosoma mansoni	serine/threonine protein kinase	0.3788	0.7647	0.7644
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Leishmania major	hypothetical protein, conserved	0.0074	0.0071	0.4246
Entamoeba histolytica	protein kinase, putative	0.0093	0.0111	0.0463
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0059	0.0041	0.0266
Brugia malayi	serine/threonine kinase 12	0.0081	0.0086	0.008
Leishmania major	protein kinase, putative	0.0093	0.0111	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Entamoeba histolytica	hypothetical protein	0.0172	0.0272	0.1526
Brugia malayi	hypothetical protein	0.0059	0.0041	0.0036
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Brugia malayi	Dynamin	0.0074	0.0071	0.0066
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0059	0.0041	0.0266
Brugia malayi	Tyrosine-protein kinase PR2	0.0059	0.0041	0.0036
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0093	0.0111	0.0463
Echinococcus granulosus	natriuretic peptide receptor 1	0.0059	0.0041	0.0043
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0093	0.0111	0.0463
Echinococcus granulosus	c src tyrosine kinase	0.0059	0.0041	0.0043
Schistosoma mansoni	regulator of G protein signaling	0.0801	0.1555	0.1544
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0162	0.0157
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.0071	0.0197
Entamoeba histolytica	hypothetical protein	0.0801	0.1555	1
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Echinococcus multilocularis	expressed protein	0.0801	0.1555	0.1854
Echinococcus granulosus	serine/threonine protein kinase	0.0093	0.0111	0.0127
Echinococcus granulosus	oxysterol binding protein 1	0.0074	0.0071	0.0078
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0172	0.0272	0.0267
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0074	0.0071	0.0058
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0074	0.0071	0.0168
Schistosoma mansoni	serine/threonine protein kinase	0.0059	0.0041	0.0028
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0093	0.0111	1
Schistosoma mansoni	protein kinase	0.0059	0.0041	0.0028
Echinococcus granulosus	Immunoglobulin	0.0113	0.0152	0.0175
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0074	0.0071	0.0078
Trichomonas vaginalis	centaurin alpha, putative	0.0074	0.0071	0.0457
Echinococcus granulosus	exocyst complex component 2	0.0172	0.0272	0.0319
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0801	0.1555	0.1551
Entamoeba histolytica	protein kinase domain containing protein	0.0231	0.0393	0.232
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0079	0.0082	0.5754
Schistosoma mansoni	rho gtpase activating protein	0.0074	0.0071	0.0058
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0093	0.0111	1
Brugia malayi	regulator of G-protein signaling rgs-7	0.0801	0.1555	0.1551
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0093	0.0111	0.0463
Echinococcus multilocularis	activin receptor type	0.0079	0.0082	0.0091
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0059	0.0041	0.0036
Entamoeba histolytica	hypothetical protein	0.0172	0.0272	0.1526
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0152	0.0147
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Echinococcus granulosus	regulator of G protein signaling 7	0.0801	0.1555	0.1854
Brugia malayi	Sema domain containing protein	0.0393	0.0723	0.0718
Schistosoma mansoni	serine/threonine RGC	0.0059	0.0041	0.0028
Echinococcus granulosus	plexin a4	0.1099	0.2163	0.2581
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.3788	0.7647	0.7645
Loa Loa (eye worm)	hypothetical protein	0.0393	0.0723	0.0718
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Echinococcus granulosus	Pleckstrin y	0.0074	0.0071	0.0078
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0074	0.0071	0.0197
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0081	0.0086	0.0096
Echinococcus granulosus	activated cdc42 kinase 1	0.0059	0.0041	0.0043
Entamoeba histolytica	cell surface protease gp63, putative	0.0172	0.0272	0.1526
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Schistosoma mansoni	zinc finger protein	0.0074	0.0071	0.0058
Brugia malayi	Sema domain containing protein	0.0393	0.0723	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0162	0.0157
Echinococcus multilocularis	activated cdc42 kinase 1	0.0059	0.0041	0.0043
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0059	0.0041	0.0043
Schistosoma mansoni	hypothetical protein	0.0534	0.101	0.0998
Echinococcus multilocularis	regulator of G protein signaling 7	0.0801	0.1555	0.1854
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0059	0.0041	0.0043
Entamoeba histolytica	PH domain containing protein	0.0074	0.0071	0.0197
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0074	0.0071	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0.0272	0.1751
Entamoeba histolytica	hypothetical protein	0.0074	0.0071	0.0197
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Brugia malayi	hypothetical protein	0.0801	0.1555	0.1551
Echinococcus multilocularis	axis inhibition protein axin	0.0801	0.1555	0.1854
Schistosoma mansoni	plexin	0.0534	0.101	0.0998
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Schistosoma mansoni	protein kinase	0.0081	0.0086	0.0073
Echinococcus multilocularis	beta adrenergic receptor kinase	0.3788	0.7647	0.914
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0071	0.0066
Echinococcus granulosus	tyrosine kinase	0.0059	0.0041	0.0043
Schistosoma mansoni	regulator of G protein signaling	0.0801	0.1555	0.1544
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Echinococcus multilocularis	Oxysterol binding protein 11	0.0074	0.0071	0.0078
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Loa Loa (eye worm)	hypothetical protein	0.0534	0.101	0.1005
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Trichomonas vaginalis	AGC family protein kinase	0.0081	0.0086	0.0552
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0059	0.0041	0.0043
Loa Loa (eye worm)	TK/ALK protein kinase	0.0305	0.0544	0.0539
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Toxoplasma gondii	Oxysterol-binding protein	0.0074	0.0071	0.4246
Echinococcus granulosus	protein tyrosine kinase	0.0059	0.0041	0.0043
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0059	0.0041	0.0043
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0059	0.0041	0.0043
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.0071	0.0197
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Schistosoma mansoni	hypothetical protein	0.0172	0.0272	0.0259
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Entamoeba histolytica	hypothetical protein	0.0074	0.0071	0.0197
Schistosoma mansoni	hypothetical protein	0.0172	0.0272	0.0259
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0093	0.0111	1
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0093	0.0111	0.0106
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0071	0.0457
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0152	0.0147
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Schistosoma mansoni	protein kinase	0.0059	0.0041	0.0028
Brugia malayi	Guanylyl cyclase protein 23	0.0059	0.0041	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Trypanosoma cruzi	hypothetical protein	0.0074	0.0071	0.4246
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.2987	0.6013	0.7185
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0.0272	0.1751
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.0071	0.0197
Loa Loa (eye worm)	TK/DDR protein kinase	0.0059	0.0041	0.0036
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0041	0.0036
Echinococcus multilocularis	transfer RNA-Thr	0.0059	0.0041	0.0043
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0059	0.0041	0.0043
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Trichomonas vaginalis	AGC family protein kinase	0.0081	0.0086	0.0552
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.4141	0.8366	1
Brugia malayi	PH domain containing protein	0.0074	0.0071	0.0066
Schistosoma mansoni	regulator of G protein signaling	0.0801	0.1555	0.1544
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0059	0.0041	0.0036
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.0071	0.0197
Schistosoma mansoni	hypothetical protein	0.0074	0.0071	0.0058
Loa Loa (eye worm)	TK/ACK protein kinase	0.0059	0.0041	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0071	0.0457
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Trypanosoma cruzi	NIMA-related kinase, putative	0.0093	0.0111	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0059	0.0041	0.0043
Echinococcus granulosus	cytohesin 1	0.0074	0.0071	0.0078
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0074	0.0071	0.0078
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0059	0.0041	0.0036
Loa Loa (eye worm)	rho-GTPase-activating	0.0074	0.0071	0.0066
Echinococcus multilocularis	oxysterol binding protein 1	0.0074	0.0071	0.0078
Schistosoma mansoni	serine/threonine protein kinase	0.0059	0.0041	0.0028
Echinococcus granulosus	defective proboscis extension response	0.0113	0.0152	0.0175
Trichomonas vaginalis	alpha chimerin, putative	0.0074	0.0071	0.0457
Trypanosoma cruzi	hypothetical protein	0.0074	0.0071	0.4246
Entamoeba histolytica	hypothetical protein	0.0074	0.0071	0.0197
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0113	0.0152	0.0175
Schistosoma mansoni	protein kinase	0.0059	0.0041	0.0028
Trypanosoma cruzi	PH domain containing protein, putative	0.0074	0.0071	0.4246
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0074	0.0071	0.0457
Echinococcus granulosus	expressed protein	0.0801	0.1555	0.1854
Echinococcus granulosus	axis inhibition protein axin	0.0801	0.1555	0.1854
Brugia malayi	Fibronectin type III domain containing protein	0.0118	0.0162	0.0157
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0059	0.0041	0.0036
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0113	0.0152	0.0175
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0074	0.0071	0.4246
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0074	0.0071	0.0058
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0059	0.0041	0.0043
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0059	0.0041	0.0043
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0059	0.0041	0.0036
Brugia malayi	Pleckstrin Homology Domain	0.0074	0.0071	0.0066
Onchocerca volvulus		0.0074	0.0071	0.0168
Onchocerca volvulus		0.0074	0.0071	0.0168
Brugia malayi	DNA-binding protein LAG-1	0.0172	0.0272	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0801	0.1555	0.1551
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0071	0.0066
Echinococcus multilocularis	protein tyrosine kinase	0.0059	0.0041	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Trypanosoma cruzi	hypothetical protein	0.0074	0.0071	0.4246
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Schistosoma mansoni	axis inhibition protein axin	0.0801	0.1555	0.1544
Schistosoma mansoni	oxysterol-binding protein 1	0.0074	0.0071	0.0058
Brugia malayi	integrin-linked kinase	0.0059	0.0041	0.0036
Schistosoma mansoni	oxysterol-binding protein 1	0.0074	0.0071	0.0058
Brugia malayi	Cadps2 protein	0.0074	0.0071	0.0066
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0093	0.0111	1
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.4141	0.8366	0.8365
Loa Loa (eye worm)	TK/CSK protein kinase	0.0059	0.0041	0.0036
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0059	0.0041	0.0036
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.4141	0.8366	1
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0.0272	0.1751
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0059	0.0041	0.0043
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0041	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0041	0.0266
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.0071	0.0197
Brugia malayi	Variant SH3 domain containing protein	0.0074	0.0071	0.0066
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.0071	0.0197
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0074	0.0071	0.0066
Onchocerca volvulus		0.0074	0.0071	0.0168
Echinococcus multilocularis	tyrosine protein kinase csk	0.0059	0.0041	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0801	0.1555	1
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0059	0.0041	0.0043
Plasmodium falciparum	protein kinase, putative	0.0079	0.0082	0.5754
Onchocerca volvulus		0.0927	0.1812	1
Schistosoma mansoni	fibrocystin l	0.0172	0.0272	0.0259
Schistosoma mansoni	axis inhibition protein axin	0.0801	0.1555	0.1544
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0074	0.0071	0.0078
Echinococcus granulosus	semaphorin 5B	0.0393	0.0723	0.0858
Entamoeba histolytica	protein kinase domain containing protein	0.0079	0.0082	0.0266
Echinococcus granulosus	regulator of G protein signaling 3	0.0801	0.1555	0.1854
Onchocerca volvulus		0.0074	0.0071	0.0168
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0074	0.0071	0.4246
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0071	0.0457
Echinococcus granulosus	Pleckstrin y	0.0074	0.0071	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0071	0.0066
Schistosoma mansoni	protein kinase	0.0059	0.0041	0.0028
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0074	0.0071	0.0197
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0059	0.0041	0.0043
Schistosoma mansoni	nephrin	0.0118	0.0162	0.0149
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0059	0.0041	0.0043
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Leishmania major	protein kinase, putative	0.0079	0.0082	0.5754
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0079	0.0082	0.5754
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0059	0.0041	0.0043
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0801	0.1555	0.1544
Trichomonas vaginalis	protein kinase atn1, putative	0.0059	0.0041	0.0266
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0801	0.1555	0.1854
Loa Loa (eye worm)	plexin A	0.1099	0.2163	0.2159
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Brugia malayi	PH domain containing protein	0.0074	0.0071	0.0066
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Echinococcus granulosus	Rho GTPase activating protein 24	0.0074	0.0071	0.0078
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0093	0.0111	0.0463
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0059	0.0041	0.0043
Plasmodium falciparum	PH domain-containing protein, putative	0.0074	0.0071	0.4246
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0059	0.0041	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0152	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0071	0.0066
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0093	0.0111	0.0463
Echinococcus multilocularis	hypothetical protein	0.0393	0.0723	0.0858
Schistosoma mansoni	myotubularin-related protein	0.0074	0.0071	0.0058
Loa Loa (eye worm)	syntrophin-1	0.0074	0.0071	0.0066
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Schistosoma mansoni	protein kinase	0.0059	0.0041	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0162	0.0157
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0059	0.0041	0.0043
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0059	0.0041	0.0043
Trypanosoma cruzi	Protein kinase B	0.0093	0.0111	1
Echinococcus multilocularis	oxysterol binding protein 9	0.0074	0.0071	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0716
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0074	0.0071	0.0078
Brugia malayi	Uncoordinated protein 104	0.0074	0.0071	0.0066
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Brugia malayi	PH domain containing protein	0.0074	0.0071	0.0066
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0059	0.0041	0.0043
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0059	0.0041	0.0043
Echinococcus multilocularis	actin binding protein anillin	0.0074	0.0071	0.0078
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0059	0.0041	0.0043
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0059	0.0041	0.0043
Echinococcus granulosus	axis inhibition protein axin	0.0801	0.1555	0.1854
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0266
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0041	0.0036
Echinococcus multilocularis	regulator of G protein signaling 3	0.0801	0.1555	0.1854
Schistosoma mansoni	serine/threonine protein kinase	0.0081	0.0086	0.0073

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 1500 nM	Growth inhibition of human DLD1 cells after 72 hrs by MTT assay	ChEMBL.	19022679
IC50 (functional)	= 3200 nM	Growth inhibition of human PANC1 cells after 72 hrs by MTT assay	ChEMBL.	19022679
IC50 (functional)	= 4900 nM	Growth inhibition of human AsPC1 cells after 72 hrs by MTT assay	ChEMBL.	19022679

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	19022679

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL475687

Bibliographic References

No literature references available for this target.

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Detailed information for compound 980611