TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 418.455 | Formula: C22H25F3N4O
H donors: 1 H acceptors: 3 LogP: 3.69 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCCCN(CC(c1ccc(cc1F)F)(Cn1ncnc1)O)Cc1cccc(c1)F
InChi: 1S/C22H25F3N4O/c1-2-3-9-28(12-17-5-4-6-18(23)10-17)13-22(30,14-29-16-26-15-27-29)20-8-7-19(24)11-21(20)25/h4-8,10-11,15-16,30H,2-3,9,12-14H2,1H3
InChiKey: RZPJTSFCJURVJY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	kinesin light chain, putative	0.0059	0.0051	0.0333
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0458	0.1073	0.1067
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0055	0.0041	0.004
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0059	0.0051	0.0157
Brugia malayi	PH domain containing protein	0.0059	0.0051	0.0044
Loa Loa (eye worm)	RGS-3 protein	0.064	0.1538	0.1533
Trypanosoma brucei	protein kinase, putative	0.0075	0.0092	0.9675
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0059	0.0051	0.0157
Schistosoma mansoni	vav2	0.0059	0.0051	0.0035
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0051	0.0044
Echinococcus multilocularis	tyrosine protein kinase csk	0.005	0.0028	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0118	0.0111
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Brugia malayi	PH domain containing protein	0.0059	0.0051	0.0044
Loa Loa (eye worm)	TK protein kinase	0.005	0.0028	0.0021
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Trypanosoma cruzi	PH domain containing protein, putative	0.0059	0.0051	0.356
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Loa Loa (eye worm)	AUR protein kinase	0.0075	0.0094	0.0087
Echinococcus granulosus	defective proboscis extension response	0.008	0.0105	0.0118
Schistosoma mansoni	hypothetical protein	0.0059	0.0051	0.0035
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.005	0.0028	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0051	0.0333
Echinococcus multilocularis	roundabout 2	0.0085	0.0118	0.0133
Echinococcus granulosus	fibroblast growth factor receptor 4	0.005	0.0028	0.0025
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0148	0.028	0.1822
Loa Loa (eye worm)	syntrophin-1	0.0059	0.0051	0.0044
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.005	0.0028	0.0021
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0065	0.0068	0.6115
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0059	0.0051	0.0035
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Echinococcus multilocularis	protein tyrosine kinase	0.005	0.0028	0.0025
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0021
Schistosoma mansoni	serine/threonine RGC	0.005	0.0028	0.0011
Echinococcus multilocularis	tyrosine protein kinase Blk	0.005	0.0028	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0051	0.0333
Brugia malayi	Immunoglobulin I-set domain containing protein	0.005	0.0028	0.0021
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.005	0.0028	0.0011
Entamoeba histolytica	hypothetical protein	0.064	0.1538	1
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Echinococcus granulosus	semaphorin 5B	0.0339	0.0767	0.0909
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.005	0.0028	0.0021
Loa Loa (eye worm)	PXA domain-containing protein	0.064	0.1538	0.1533
Brugia malayi	TBC domain containing protein	0.0059	0.0051	0.0044
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.064	0.1538	0.1533
Echinococcus multilocularis	transfer RNA-Thr	0.005	0.0028	0.0025
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0059	0.0051	0.356
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Echinococcus granulosus	Pleckstrin y	0.0059	0.0051	0.0053
Echinococcus multilocularis	activin receptor type	0.0065	0.0068	0.0073
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0059	0.0051	0.0157
Trichomonas vaginalis	centaurin gamma, putative	0.0059	0.0051	0.0333
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Echinococcus multilocularis	regulator of G protein signaling 3	0.064	0.1538	0.1833
Loa Loa (eye worm)	hypothetical protein	0.0148	0.028	0.0274
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0059	0.0051	0.356
Loa Loa (eye worm)	RGC/RGC protein kinase	0.005	0.0028	0.0021
Trypanosoma cruzi	hypothetical protein	0.0059	0.0051	0.356
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0059	0.0051	0.0053
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Echinococcus multilocularis	Immunoglobulin	0.008	0.0105	0.0118
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0021
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0059	0.0051	0.0124
Loa Loa (eye worm)	TK/Met protein kinase	0.005	0.0028	0.0021
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0075	0.0094	0.044
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.005	0.0028	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.064	0.1538	1
Brugia malayi	Sema domain containing protein	0.0339	0.0767	0.076
Echinococcus granulosus	ephrin type A receptor 4 A	0.005	0.0028	0.0025
Schistosoma mansoni	serine/threonine-protein kinase	0.0075	0.0092	0.0075
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0021
Trichomonas vaginalis	conserved hypothetical protein	0.064	0.1538	1
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.064	0.1538	0.1524
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0021
Brugia malayi	SH2 domain containing protein	0.005	0.0028	0.0021
Entamoeba histolytica	hypothetical protein	0.0059	0.0051	0.0157
Trypanosoma cruzi	Protein kinase B	0.0075	0.0092	0.9675
Schistosoma mansoni	myotubularin-related protein	0.0059	0.0051	0.0035
Entamoeba histolytica	hypothetical protein	0.0059	0.0051	0.0157
Loa Loa (eye worm)	hypothetical protein	0.064	0.1538	0.1533
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Entamoeba histolytica	hypothetical protein	0.0148	0.028	0.1673
Loa Loa (eye worm)	TK protein kinase	0.005	0.0028	0.0021
Schistosoma mansoni	protein kinase	0.0065	0.0068	0.0052
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0051	0.0044
Echinococcus multilocularis	pdz domain containing protein	0.0059	0.0051	0.0053
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.005	0.0028	0.0025
Trypanosoma cruzi	NIMA-related kinase, putative	0.0075	0.0092	0.9675
Echinococcus granulosus	semaphorin 1A	0.0339	0.0767	0.0909
Onchocerca volvulus	outspread protein homolog	0.0059	0.0051	0.0124
Trypanosoma brucei	aurora B kinase	0.0075	0.0094	1
Trypanosoma cruzi	NIMA-related kinase, putative	0.0075	0.0092	0.9675
Echinococcus multilocularis	regulator of G protein signaling	0.064	0.1538	0.1833
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0075	0.0092	0.9675
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0021
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.005	0.0028	0.0021
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0059	0.0051	0.0044
Loa Loa (eye worm)	sema domain-containing protein	0.0339	0.0767	0.076
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.005	0.0028	0.0025
Brugia malayi	PH domain containing protein	0.0059	0.0051	0.0044
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0059	0.0051	0.0035
Schistosoma mansoni	growth factor receptor-bound protein	0.0059	0.0051	0.0035
Loa Loa (eye worm)	TK/ALK protein kinase	0.0295	0.0655	0.0649
Echinococcus granulosus	regulator of G protein signaling 7	0.064	0.1538	0.1833
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0059	0.0051	0.0157
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.005	0.0028	0.0021
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Echinococcus granulosus	plexin a4	0.0945	0.2318	0.2766
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0075	0.0092	0.0598
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.005	0.0028	0.0025
Echinococcus granulosus	myotubularin protein 13	0.0059	0.0051	0.0053
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0075	0.0094	0.0104
Schistosoma mansoni	protein kinase	0.005	0.0028	0.0011
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0129	0.0232	0.0225
Echinococcus multilocularis	protein kinase	0.005	0.0028	0.0025
Entamoeba histolytica	hypothetical protein	0.0059	0.0051	0.0157
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.005	0.0028	0.0025
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0021
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.008	0.0105	0.0118
Loa Loa (eye worm)	hypothetical protein	0.064	0.1538	0.1533
Echinococcus granulosus	retinal guanylyl cyclase 2	0.005	0.0028	0.0025
Schistosoma mansoni	z-protein (S1r protein)	0.064	0.1538	0.1524
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0065	0.0068	0.0073
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Trichomonas vaginalis	centaurin beta, putative	0.0059	0.0051	0.0333
Brugia malayi	hypothetical protein	0.0339	0.0767	0.076
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0148	0.028	0.1822
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0059	0.0051	0.356
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.3028	0.7642	0.7641
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0055	0.0041	0.004
Entamoeba histolytica	protein kinase, putative	0.0075	0.0092	0.0426
Plasmodium falciparum	oxysterol-binding protein, putative	0.0059	0.0051	0.356
Onchocerca volvulus		0.0059	0.0051	0.0124
Brugia malayi	Furin-like cysteine rich region family protein	0.005	0.0028	0.0021
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0028	0.0011
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0021
Echinococcus granulosus	regulator of G protein signaling 3	0.064	0.1538	0.1833
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0075	0.0092	0.9675
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0059	0.0051	0.0157
Schistosoma mansoni	plexin	0.0797	0.1939	0.1925
Entamoeba histolytica	hypothetical protein	0.0075	0.0092	0.0426
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0094	0.0612
Trypanosoma cruzi	PH domain containing protein, putative	0.0059	0.0051	0.356
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.005	0.0028	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Echinococcus granulosus	oxysterol binding protein 1	0.0059	0.0051	0.0053
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.005	0.0028	0.0025
Echinococcus granulosus	activated cdc42 kinase 1	0.005	0.0028	0.0025
Loa Loa (eye worm)	hypothetical protein	0.064	0.1538	0.1533
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0118	0.0111
Trypanosoma cruzi	hypothetical protein	0.0059	0.0051	0.356
Schistosoma mansoni	serine/threonine protein kinase	0.3028	0.7642	0.7638
Schistosoma mansoni	zinc finger protein	0.0059	0.0051	0.0035
Loa Loa (eye worm)	rho-GTPase-activating	0.0059	0.0051	0.0044
Brugia malayi	PXA domain containing protein	0.064	0.1538	0.1533
Plasmodium falciparum	protein kinase, putative	0.0065	0.0068	0.6115
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Schistosoma mansoni	rho gtpase activating protein	0.0059	0.0051	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0339	0.0767	0.076
Schistosoma mansoni	hypothetical protein	0.0458	0.1073	0.1058
Brugia malayi	Uncoordinated protein 104	0.0059	0.0051	0.0044
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.064	0.1538	1
Schistosoma mansoni	serine/threonine protein kinase	0.0075	0.0094	0.0078
Brugia malayi	serine/threonine-protein kinase 6	0.0075	0.0094	0.0087
Schistosoma mansoni	hypothetical protein	0.0339	0.0767	0.0751
Echinococcus granulosus	regulator of G protein signaling 3	0.064	0.1538	0.1833
Echinococcus granulosus	natriuretic peptide receptor 1	0.005	0.0028	0.0025
Trypanosoma cruzi	PH domain containing protein, putative	0.0059	0.0051	0.356
Echinococcus multilocularis	neuroglian	0.008	0.0105	0.0118
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0021
Schistosoma mansoni	protein kinase	0.005	0.0028	0.0011
Schistosoma mansoni	ephrin receptor	0.005	0.0028	0.0011
Entamoeba histolytica	protein kinase, putative	0.0075	0.0092	0.0426
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0028	0.018
Echinococcus granulosus	GRB2 associated binding protein 3	0.0059	0.0051	0.0053
Loa Loa (eye worm)	plexin A	0.0945	0.2318	0.2312
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.005	0.0028	0.0025
Loa Loa (eye worm)	hypothetical protein	0.064	0.1538	0.1533
Entamoeba histolytica	hypothetical protein	0.0148	0.028	0.1673
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0051	0.0333
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0059	0.0051	0.356
Echinococcus granulosus	tyrosine protein kinase ABL1	0.005	0.0028	0.0025
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0075	0.0092	0.9675
Echinococcus multilocularis	tyrosine protein kinase Srms	0.005	0.0028	0.0025
Entamoeba histolytica	protein kinase, putative	0.0075	0.0094	0.044
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.064	0.1538	0.1833
Echinococcus multilocularis	insulin receptor	0.005	0.0028	0.0025
Echinococcus multilocularis	dynamin 1	0.0059	0.0051	0.0053
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.005	0.0028	0.0025
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Schistosoma mansoni	regulator of G protein signaling	0.064	0.1538	0.1524
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0059	0.0051	0.0333
Brugia malayi	Raf kinase	0.005	0.0028	0.0021
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Echinococcus granulosus	Pleckstrin y	0.0059	0.0051	0.0053
Echinococcus granulosus	Pleckstrin y	0.0059	0.0051	0.0053
Echinococcus granulosus	tyrosine protein kinase shark	0.005	0.0028	0.0025
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.028	0.1822
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Plasmodium vivax	PH domain containing protein	0.0059	0.0051	0.356
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Brugia malayi	A-kinase anchor protein 10, precursor	0.064	0.1538	0.1533
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0075	0.0092	0.0426
Schistosoma mansoni	plexin	0.0458	0.1073	0.1058
Echinococcus granulosus	beta-adrenergic receptor kinase	0.3028	0.7642	0.9138
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0339	0.0767	0.076
Brugia malayi	Variant SH3 domain containing protein	0.0059	0.0051	0.0044
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.005	0.0028	0.0025
Echinococcus granulosus	tyrosine protein kinase Src64B	0.005	0.0028	0.0025
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0075	0.0092	0.9675
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Brugia malayi	hypothetical protein	0.0339	0.0767	0.076
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.005	0.0028	0.0025
Brugia malayi	hypothetical protein	0.064	0.1538	0.1533
Loa Loa (eye worm)	TK/RYK protein kinase	0.005	0.0028	0.0021
Toxoplasma gondii	aurora kinase	0.0075	0.0094	1
Echinococcus granulosus	epidermal growth factor receptor	0.005	0.0028	0.0025
Brugia malayi	PH domain containing protein	0.0059	0.0051	0.0044
Trichomonas vaginalis	protein transport protein sec7, putative	0.0059	0.0051	0.0333
Schistosoma mansoni	oxysterol-binding protein 1	0.0059	0.0051	0.0035
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Loa Loa (eye worm)	hypothetical protein	0.008	0.0105	0.0098
Echinococcus granulosus	Immunoglobulin	0.008	0.0105	0.0118
Entamoeba histolytica	PH domain containing protein	0.0059	0.0051	0.0157
Echinococcus granulosus	axis inhibition protein axin	0.064	0.1538	0.1833
Brugia malayi	Cytohesin 3	0.0059	0.0051	0.0044
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.005	0.0028	0.0021
Trichomonas vaginalis	centaurin/arf, putative	0.0059	0.0051	0.0333
Echinococcus multilocularis	FL cytokine receptor	0.005	0.0028	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0051	0.0333
Echinococcus granulosus	pdz domain containing protein	0.0059	0.0051	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0339	0.0767	0.076
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Loa Loa (eye worm)	TK/INSR protein kinase	0.005	0.0028	0.0021
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.005	0.0028	0.0025
Schistosoma mansoni	protein kinase	0.005	0.0028	0.0011
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0059	0.0051	0.0157
Schistosoma mansoni	ephrin receptor	0.0055	0.0041	0.0024
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.3309	0.8363	1
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0075	0.0092	0.0426
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0148	0.028	0.1822
Loa Loa (eye worm)	cytohesin 3	0.0059	0.0051	0.0044
Onchocerca volvulus		0.0797	0.1939	1
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0051	0.0333
Echinococcus granulosus	dynamin 1	0.0059	0.0051	0.0053
Entamoeba histolytica	protein kinase , putative	0.0075	0.0094	0.044
Entamoeba histolytica	hypothetical protein	0.064	0.1538	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.005	0.0028	0.0025
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0094	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.028	0.1822
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0075	0.0092	0.9675
Brugia malayi	Probable exocyst complex component Sec5	0.0148	0.028	0.0274
Echinococcus granulosus	tyrosine protein kinase Fyn	0.005	0.0028	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Echinococcus multilocularis	plexin a4	0.0945	0.2318	0.2766
Echinococcus multilocularis	expressed protein	0.064	0.1538	0.1833
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.005	0.0028	0.0025
Brugia malayi	PH domain containing protein	0.0059	0.0051	0.0044
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Echinococcus multilocularis	axis inhibition protein axin	0.064	0.1538	0.1833
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Trichomonas vaginalis	TK family protein kinase	0.005	0.0028	0.018
Schistosoma mansoni	regulator of G protein signaling	0.064	0.1538	0.1524
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0059	0.0051	0.0053
Echinococcus multilocularis	hypothetical protein	0.0339	0.0767	0.0909
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0051	0.0044
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.005	0.0028	0.0025
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0059	0.0051	0.0053
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0065	0.0068	0.6115
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.064	0.1538	0.1524
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0148	0.028	0.1822
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0075	0.0092	0.9675
Echinococcus multilocularis	tyrosine protein kinase Abl	0.005	0.0028	0.0025
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.005	0.0028	0.0021
Echinococcus multilocularis	regulator of G protein signaling 3	0.064	0.1538	0.1833
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Schistosoma mansoni	protein kinase	0.005	0.0028	0.0011
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.005	0.0028	0.0025
Echinococcus multilocularis	integrin linked protein kinase	0.005	0.0028	0.0025
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0059	0.0051	0.0053
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0059	0.0051	0.0035
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Schistosoma mansoni	oxysterol-binding protein 1	0.0059	0.0051	0.0035
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0051	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0051	0.0044
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0075	0.0092	0.9675
Trypanosoma cruzi	PH domain containing protein, putative	0.0059	0.0051	0.356
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0021
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.008	0.0105	0.0118
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Trichomonas vaginalis	STE family protein kinase	0.005	0.0028	0.018
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Brugia malayi	IPT/TIG domain containing protein	0.0148	0.028	0.0274
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Loa Loa (eye worm)	TK/ACK protein kinase	0.005	0.0028	0.0021
Trichomonas vaginalis	protein transport protein sec7, putative	0.0059	0.0051	0.0333
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Echinococcus granulosus	kinase suppressor of Ras 1	0.005	0.0028	0.0025
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Trichomonas vaginalis	protein tyrosine kinase, putative	0.005	0.0028	0.018
Echinococcus multilocularis	transcription factor collier	0.0148	0.028	0.0327
Brugia malayi	regulator of G-protein signaling rgs-7	0.064	0.1538	0.1533
Schistosoma mansoni	serine/threonine-protein kinase	0.0075	0.0092	0.0075
Schistosoma mansoni	syntrophin	0.0059	0.0051	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0051	0.0044
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.005	0.0028	0.0025
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0075	0.0092	0.9675
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Echinococcus granulosus	regulator of G protein signaling 7	0.064	0.1538	0.1833
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0059	0.0051	0.0333
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0059	0.0051	0.0157
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Loa Loa (eye worm)	RGC/RGC protein kinase	0.005	0.0028	0.0021
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0059	0.0051	0.0053
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0059	0.0051	0.0157
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Brugia malayi	DNA-binding protein LAG-1	0.0148	0.028	0.0274
Brugia malayi	Regulator of G protein signaling domain containing protein	0.064	0.1538	0.1533
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0075	0.0092	0.0598
Loa Loa (eye worm)	hypothetical protein	0.064	0.1538	0.1533
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.005	0.0028	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0051	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0051	0.0044
Echinococcus granulosus	tyrosine protein kinase csk	0.005	0.0028	0.0025
Entamoeba histolytica	protein kinase domain containing protein	0.0198	0.0407	0.251
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0059	0.0051	0.0157
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0059	0.0051	0.0333
Schistosoma mansoni	hypothetical protein	0.0059	0.0051	0.0035
Entamoeba histolytica	protein kinase, putative	0.0075	0.0092	0.0426
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Loa Loa (eye worm)	TK protein kinase	0.005	0.0028	0.0021
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0051	0.0333
Schistosoma mansoni	protein kinase	0.005	0.0028	0.0011
Echinococcus granulosus	beta 1 syntrophin	0.0059	0.0051	0.0053
Echinococcus granulosus	tyrosine protein kinase Blk	0.005	0.0028	0.0025
Echinococcus multilocularis	protein KINase family member (kin 25)	0.005	0.0028	0.0025
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0059	0.0051	0.0053
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.3309	0.8363	0.8361
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Onchocerca volvulus	Protein melted homolog	0.0059	0.0051	0.0124
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0028	0.018
Schistosoma mansoni	hypothetical protein	0.0339	0.0767	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0051	0.0044
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0075	0.0092	0.9675
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Plasmodium vivax	hypothetical protein, conserved	0.0059	0.0051	0.356
Entamoeba histolytica	PH domain containing protein	0.0059	0.0051	0.0157
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0059	0.0051	0.0157
Trichomonas vaginalis	hypothetical protein	0.0059	0.0051	0.0333
Loa Loa (eye worm)	TK/CSK protein kinase	0.005	0.0028	0.0021
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Trichomonas vaginalis	alpha chimerin, putative	0.0059	0.0051	0.0333
Brugia malayi	ephrin receptor 1 precursor	0.005	0.0028	0.0021
Schistosoma mansoni	cell adhesion molecule	0.0085	0.0118	0.0102
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.005	0.0028	0.0021
Schistosoma mansoni	protein kinase	0.005	0.0028	0.0011
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Echinococcus granulosus	serine/threonine protein kinase	0.0075	0.0092	0.0102
Loa Loa (eye worm)	Plekhf2 protein	0.0059	0.0051	0.0044
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0339	0.0767	0.076
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Brugia malayi	Regulator of G protein signaling domain containing protein	0.064	0.1538	0.1533
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0059	0.0051	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0051	0.0044
Echinococcus granulosus	tyrosine protein kinase Fyn	0.005	0.0028	0.0025
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.064	0.1538	0.1524
Entamoeba histolytica	protein kinase, putative	0.0075	0.0092	0.0426
Onchocerca volvulus		0.0059	0.0051	0.0124
Schistosoma mansoni	nephrin	0.0085	0.0118	0.0102
Brugia malayi	C-terminal src kinase protein 1	0.005	0.0028	0.0021
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0059	0.0051	0.0044
Schistosoma mansoni	protein kinase	0.005	0.0028	0.0011
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0059	0.0051	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0051	0.0333
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0059	0.0051	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0051	0.0044
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Schistosoma mansoni	hypothetical protein	0.0059	0.0051	0.0035
Trypanosoma cruzi	hypothetical protein	0.0059	0.0051	0.356
Brugia malayi	hypothetical protein	0.0059	0.0051	0.0044
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0051	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0148	0.028	0.0274
Echinococcus granulosus	insulin receptor	0.005	0.0028	0.0025
Schistosoma mansoni	regulator of G protein signaling	0.064	0.1538	0.1524
Loa Loa (eye worm)	TK protein kinase	0.005	0.0028	0.0021
Echinococcus granulosus	tyrosine protein kinase csk	0.005	0.0028	0.0025
Echinococcus granulosus	G protein coupled receptor kinase 1	0.2387	0.6005	0.7178
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0059	0.0051	0.0053
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.028	0.1822
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0065	0.0068	0.6115
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0059	0.0051	0.0044
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Echinococcus granulosus	tyrosine protein kinase Srms	0.005	0.0028	0.0025
Loa Loa (eye worm)	protein kinase domain-containing protein	0.005	0.0028	0.0021
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0075	0.0094	0.0104
Schistosoma mansoni	protein kinase	0.005	0.0028	0.0011
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0028	0.018
Brugia malayi	probable spectrin beta chain	0.0059	0.0051	0.0044
Echinococcus multilocularis	myotubularin protein 13	0.0059	0.0051	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.064	0.1538	1
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Trypanosoma cruzi	hypothetical protein	0.0059	0.0051	0.356
Echinococcus granulosus	transcription factor collier	0.0148	0.028	0.0327
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0021
Brugia malayi	Receptor family ligand binding region containing protein	0.005	0.0028	0.0021
Brugia malayi	Plexin repeat family protein	0.0797	0.1939	0.1933
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0085	0.0118	0.0111
Loa Loa (eye worm)	TK protein kinase	0.005	0.0028	0.0021
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Schistosoma mansoni	hypothetical protein	0.0148	0.028	0.0264
Brugia malayi	serine/threonine kinase 12	0.0075	0.0094	0.0087
Echinococcus multilocularis	oxysterol binding protein 3	0.0059	0.0051	0.0053
Loa Loa (eye worm)	TK protein kinase	0.005	0.0028	0.0021
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0075	0.0092	0.9675
Brugia malayi	Fibronectin type III domain containing protein	0.0085	0.0118	0.0111
Echinococcus multilocularis	heat shock protein 70	0.005	0.0028	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0051	0.0333
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0059	0.0051	0.0053
Brugia malayi	Oxysterol-binding protein	0.0059	0.0051	0.0044
Brugia malayi	Tyrosine-protein kinase abl-1	0.005	0.0028	0.0021
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0094	0.0612
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.005	0.0028	0.0011
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0028	0.018
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Brugia malayi	bone morphogenetic protein type 1 receptor	0.005	0.0028	0.0021
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0075	0.0092	0.9675
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0059	0.0051	0.356
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0021
Schistosoma mansoni	protein kinase	0.0065	0.0068	0.0052
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0059	0.0051	0.0053
Schistosoma mansoni	serine/threonine protein kinase	0.395	1	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.005	0.0028	0.0021
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0028	0.018
Entamoeba histolytica	protein kinase, putative	0.0075	0.0092	0.0426
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.395	1	1
Trypanosoma cruzi	hypothetical protein	0.0059	0.0051	0.356
Loa Loa (eye worm)	hypothetical protein	0.0216	0.0454	0.0447
Toxoplasma gondii	hypothetical protein	0.0059	0.0051	0.356
Brugia malayi	protein-tyrosine kinase	0.005	0.0028	0.0021
Trichomonas vaginalis	protein kinase atn1, putative	0.005	0.0028	0.018
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Schistosoma mansoni	centaurin alpha	0.0059	0.0051	0.0035
Trichomonas vaginalis	conserved hypothetical protein	0.064	0.1538	1
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.2387	0.6005	0.7178
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0051	0.0044
Echinococcus multilocularis	c src tyrosine kinase	0.005	0.0028	0.0025
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0075	0.0092	0.9675
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Echinococcus multilocularis	exocyst complex component 2	0.0148	0.028	0.0327
Entamoeba histolytica	hypothetical protein	0.0148	0.028	0.1673
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0075	0.0092	0.0085
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.005	0.0028	0.0025
Echinococcus multilocularis	actin binding protein anillin	0.0059	0.0051	0.0053
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0021
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0075	0.0092	0.9675
Trypanosoma cruzi	aurora B kinase, putative	0.0075	0.0094	1
Brugia malayi	serine/threonine protein kinase 6	0.0075	0.0094	0.0087
Echinococcus multilocularis	tyrosine protein kinase csk	0.005	0.0028	0.0025
Loa Loa (eye worm)	sema domain-containing protein	0.0339	0.0767	0.076
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.008	0.0105	0.0089
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0028	0.0011
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.005	0.0028	0.018
Brugia malayi	hypothetical protein	0.005	0.0028	0.0021
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.005	0.0028	0.0025
Echinococcus multilocularis	regulator of G protein signaling 7	0.064	0.1538	0.1833
Schistosoma mansoni	axis inhibition protein axin	0.064	0.1538	0.1524
Onchocerca volvulus		0.0339	0.0767	0.3868
Schistosoma mansoni	axis inhibition protein axin	0.064	0.1538	0.1524
Echinococcus multilocularis	semaphorin 5B	0.0339	0.0767	0.0909
Echinococcus granulosus	tyrosine kinase	0.005	0.0028	0.0025
Echinococcus granulosus	protein tyrosine kinase	0.005	0.0028	0.0025
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0021
Brugia malayi	hypothetical protein	0.064	0.1538	0.1533
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Toxoplasma gondii	protein kinase domain-containing protein	0.0075	0.0092	0.9675
Echinococcus multilocularis	Oxysterol binding protein 11	0.0059	0.0051	0.0053
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0059	0.0051	0.356
Echinococcus granulosus	expressed protein	0.064	0.1538	0.1833
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0059	0.0051	0.0157
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0075	0.0092	0.9675
Onchocerca volvulus		0.0059	0.0051	0.0124
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.005	0.0028	0.0021
Entamoeba histolytica	protein kinase, putative	0.0075	0.0094	0.044
Loa Loa (eye worm)	serine/threonine protein kinase	0.005	0.0028	0.0021
Echinococcus granulosus	tyrosine protein kinase	0.005	0.0028	0.0025
Loa Loa (eye worm)	AUR protein kinase	0.0075	0.0094	0.0087
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0021
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.028	0.1822
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0059	0.0051	0.0333
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.005	0.0028	0.0025
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0021
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Echinococcus granulosus	calcium dependent secretion activator 1	0.0059	0.0051	0.0053
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.005	0.0028	0.0025
Echinococcus granulosus	cytohesin 1	0.0059	0.0051	0.0053
Loa Loa (eye worm)	RGC/RGC protein kinase	0.005	0.0028	0.0021
Onchocerca volvulus		0.0059	0.0051	0.0124
Echinococcus multilocularis	Regulator of G protein signaling 20	0.064	0.1538	0.1833
Echinococcus multilocularis	tyrosine protein kinase shark	0.005	0.0028	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0118	0.0111
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0051	0.0333
Brugia malayi	Guanylyl cyclase protein 23	0.005	0.0028	0.0021
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.005	0.0028	0.0025
Onchocerca volvulus		0.0059	0.0051	0.0124
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.3309	0.8363	0.8361
Leishmania major	protein kinase, putative	0.0065	0.0068	0.6115
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0059	0.0051	0.0157
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.005	0.0028	0.0025
Echinococcus multilocularis	kinase suppressor of Ras 1	0.005	0.0028	0.0025
Loa Loa (eye worm)	hypothetical protein	0.064	0.1538	0.1533
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0051	0.0333
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.005	0.0028	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Echinococcus multilocularis	raf serine:threonine protein kinase	0.005	0.0028	0.0025
Plasmodium falciparum	PH domain-containing protein, putative	0.0059	0.0051	0.356
Echinococcus multilocularis	beta 1 syntrophin	0.0059	0.0051	0.0053
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0075	0.0092	0.9675
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0075	0.0094	0.044
Echinococcus granulosus	Regulator of G protein signaling 20	0.064	0.1538	0.1833
Brugia malayi	Tyrosine-protein kinase PR2	0.005	0.0028	0.0021
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.005	0.0028	0.018
Brugia malayi	regulator of G-protein signaling egl-10	0.064	0.1538	0.1533
Brugia malayi	Variant SH3 domain containing protein	0.0059	0.0051	0.0044
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0028	0.018
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0051	0.0333
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0051	0.0333
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Leishmania major	protein kinase, putative	0.0075	0.0092	0.9675
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.005	0.0028	0.0011
Loa Loa (eye worm)	hypothetical protein	0.008	0.0105	0.0098
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.005	0.0028	0.0025
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0059	0.0051	0.0333
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0059	0.0051	0.0053
Loa Loa (eye worm)	TK protein kinase	0.005	0.0028	0.0021
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Schistosoma mansoni	hypothetical protein	0.005	0.0028	0.0011
Brugia malayi	hypothetical protein	0.005	0.0028	0.0021
Echinococcus granulosus	receptor type guanylyl cyclase	0.005	0.0028	0.0025
Toxoplasma gondii	Oxysterol-binding protein	0.0059	0.0051	0.356
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0051	0.0044
Schistosoma mansoni	serine/threonine protein kinase	0.3028	0.7642	0.7638
Entamoeba histolytica	p21-activated kinase	0.0075	0.0092	0.0426
Echinococcus granulosus	tyrosine protein kinase Src42A	0.005	0.0028	0.0025
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Loa Loa (eye worm)	hypothetical protein	0.008	0.0105	0.0098
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Echinococcus multilocularis	oxysterol binding protein 9	0.0059	0.0051	0.0053
Echinococcus multilocularis	ephrin type A receptor 4 A	0.005	0.0028	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0051	0.0044
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0075	0.0092	0.9675
Schistosoma mansoni	regulator of G protein signaling	0.064	0.1538	0.1524
Trichomonas vaginalis	centaurin alpha, putative	0.0059	0.0051	0.0333
Echinococcus granulosus	twitchin	0.0096	0.0146	0.0166
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Echinococcus multilocularis	tyrosine protein kinase csk	0.005	0.0028	0.0025
Echinococcus multilocularis	tyrosine kinase	0.005	0.0028	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0028	0.018
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0059	0.0051	0.0053
Echinococcus multilocularis	epidermal growth factor receptor	0.005	0.0028	0.0025
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0065	0.0068	0.6115
Entamoeba histolytica	cell surface protease gp63, putative	0.0148	0.028	0.1673
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.3309	0.8363	0.8361
Echinococcus multilocularis	aurora kinase A	0.0075	0.0094	0.0104
Echinococcus granulosus	exocyst complex component 2	0.0148	0.028	0.0327
Echinococcus granulosus	tyrosine protein kinase csk	0.005	0.0028	0.0025
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0059	0.0051	0.0044
Entamoeba histolytica	protein kinase, putative	0.0075	0.0092	0.0426
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Echinococcus granulosus	axis inhibition protein axin	0.064	0.1538	0.1833
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Schistosoma mansoni	tyrosine protein kinase	0.005	0.0028	0.0011
Schistosoma mansoni	goodpasture antigen-binding protein	0.0059	0.0051	0.0035
Echinococcus granulosus	raf serine:threonine protein kinase	0.005	0.0028	0.0025
Brugia malayi	SH2 domain containing protein	0.005	0.0028	0.0021
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0075	0.0092	0.0426
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0059	0.0051	0.0044
Echinococcus granulosus	activin receptor type	0.0065	0.0068	0.0073
Leishmania major	folate/biopterin transporter, putative	0.0075	0.0092	0.9675
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0028	0.018
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.005	0.0028	0.0025
Schistosoma mansoni	hypothetical protein	0.0059	0.0051	0.0035
Schistosoma mansoni	fibrocystin l	0.0148	0.028	0.0264
Leishmania major	hypothetical protein, conserved	0.0059	0.0051	0.356
Schistosoma mansoni	vesicular amine transporter	0.0083	0.0112	0.0096
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0021
Leishmania major	protein kinase, putative	0.0075	0.0092	0.9675
Loa Loa (eye worm)	TK protein kinase	0.005	0.0028	0.0021
Trichomonas vaginalis	centaurin/arf, putative	0.0059	0.0051	0.0333
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.028	0.1822
Echinococcus granulosus	aurora kinase A	0.0075	0.0094	0.0104
Echinococcus multilocularis	Pleckstrin y	0.0059	0.0051	0.0053
Trypanosoma cruzi	hypothetical protein	0.0059	0.0051	0.356
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0065	0.0068	0.0073
Echinococcus multilocularis	rac serine:threonine kinase	0.0075	0.0092	0.0102
Brugia malayi	PH domain containing protein	0.0059	0.0051	0.0044
Entamoeba histolytica	tyrosin kinase, putative	0.0198	0.0407	0.251
Loa Loa (eye worm)	AUR protein kinase	0.0075	0.0094	0.0087
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Echinococcus granulosus	integrin linked protein kinase	0.005	0.0028	0.0025
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Entamoeba histolytica	protein kinase, putative	0.0075	0.0092	0.0426
Loa Loa (eye worm)	hypothetical protein	0.0797	0.1939	0.1933
Loa Loa (eye worm)	SRC-1	0.005	0.0028	0.0021
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0065	0.0068	0.0073
Brugia malayi	PH domain containing protein	0.0059	0.0051	0.0044
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0021
Echinococcus multilocularis	Immunoglobulin	0.008	0.0105	0.0118
Trypanosoma brucei	protein kinase, putative	0.0065	0.0068	0.6115
Trypanosoma cruzi	hypothetical protein	0.0059	0.0051	0.356
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0059	0.0051	0.0053
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0059	0.0051	0.0035
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.005	0.0028	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0148	0.028	0.0274
Echinococcus granulosus	retinal guanylyl cyclase 2	0.005	0.0028	0.0025
Onchocerca volvulus		0.0059	0.0051	0.0124
Loa Loa (eye worm)	hypothetical protein	0.008	0.0105	0.0098
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0021
Loa Loa (eye worm)	RGC/RGC protein kinase	0.005	0.0028	0.0021
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Echinococcus granulosus	tyrosine kinase	0.005	0.0028	0.0025
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.005	0.0028	0.0025
Brugia malayi	Dynamin	0.0059	0.0051	0.0044
Loa Loa (eye worm)	uncoordinated protein 104	0.0059	0.0051	0.0044
Schistosoma mansoni	semaphorin 5-related	0.0339	0.0767	0.0751
Brugia malayi	Protein kinase domain containing protein	0.0075	0.0092	0.0085
Schistosoma mansoni	goodpasture antigen-binding protein	0.0059	0.0051	0.0035
Brugia malayi	PXA domain containing protein	0.064	0.1538	0.1533
Echinococcus granulosus	DCC interacting protein 13 beta	0.0059	0.0051	0.0053
Echinococcus granulosus	oxysterol binding protein 9	0.0059	0.0051	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.028	0.1822
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.005	0.0028	0.0025
Echinococcus granulosus	neuroglian	0.008	0.0105	0.0118
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.005	0.0028	0.0011
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0059	0.0051	0.0053
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.005	0.0028	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0028	0.0011
Echinococcus granulosus	oxysterol binding protein 3	0.0059	0.0051	0.0053
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.3309	0.8363	1
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Brugia malayi	Protein kinase domain containing protein	0.0295	0.0656	0.0649
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0051	0.0333
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.005	0.0028	0.0011
Echinococcus multilocularis	natriuretic peptide receptor 1	0.005	0.0028	0.0025
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0339	0.0767	0.076
Echinococcus multilocularis	regulator of G protein signaling 7	0.064	0.1538	0.1833
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.064	0.1538	0.1833
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0059	0.0051	0.356
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Echinococcus granulosus	activated cdc42 kinase 1	0.005	0.0028	0.0025
Onchocerca volvulus		0.0059	0.0051	0.0124
Brugia malayi	Cadps2 protein	0.0059	0.0051	0.0044
Echinococcus multilocularis	tyrosine protein kinase HCK	0.005	0.0028	0.0025
Brugia malayi	hypothetical protein	0.005	0.0028	0.0021
Loa Loa (eye worm)	TK/DDR protein kinase	0.005	0.0028	0.0021
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.005	0.0028	0.0025
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0021
Entamoeba histolytica	hypothetical protein	0.0075	0.0092	0.0426
Echinococcus multilocularis	epidermal growth factor receptor	0.005	0.0028	0.0025
Giardia lamblia	Aurora kinase	0.0075	0.0094	1
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Echinococcus granulosus	roundabout 2	0.0085	0.0118	0.0133
Brugia malayi	MAX-1A	0.0059	0.0051	0.0044
Toxoplasma gondii	hypothetical protein	0.0059	0.0051	0.356
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.005	0.0028	0.0025
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0059	0.0051	0.0157
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0075	0.0092	0.0426
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Loa Loa (eye worm)	TK protein kinase	0.005	0.0028	0.0021
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0021
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Echinococcus multilocularis	receptor type guanylyl cyclase	0.005	0.0028	0.0025
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.005	0.0028	0.018
Onchocerca volvulus	Putative zinc finger protein	0.0059	0.0051	0.0124
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0075	0.0092	0.9675
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.005	0.0028	0.0021
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Entamoeba histolytica	PH domain containing protein	0.0059	0.0051	0.0157
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0021
Brugia malayi	plexin A	0.0945	0.2318	0.2312
Brugia malayi	integrin-linked kinase	0.005	0.0028	0.0021
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Echinococcus granulosus	tyrosine protein kinase pr2	0.005	0.0028	0.0025
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0021
Echinococcus multilocularis	tyrosine kinase	0.005	0.0028	0.0025
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Loa Loa (eye worm)	TK/ABL protein kinase	0.005	0.0028	0.0021
Loa Loa (eye worm)	TK/ROR protein kinase	0.005	0.0028	0.0021
Loa Loa (eye worm)	hypothetical protein	0.008	0.0105	0.0098
Loa Loa (eye worm)	TK/EPH protein kinase	0.005	0.0028	0.0021
Echinococcus multilocularis	Pleckstrin y	0.0059	0.0051	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0339	0.0767	0.076
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.005	0.0028	0.0025
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Schistosoma mansoni	dynamin	0.0059	0.0051	0.0035
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0059	0.0051	0.0044
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Schistosoma mansoni	zinc finger protein	0.0059	0.0051	0.0035
Brugia malayi	Pleckstrin Homology Domain	0.0059	0.0051	0.0044
Trypanosoma brucei	PH domain containing protein, putative	0.0059	0.0051	0.356
Echinococcus granulosus	tyrosine protein kinase Fyn	0.005	0.0028	0.0025
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0059	0.0051	0.0157
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0059	0.0051	0.356
Brugia malayi	Syntrophin-1	0.0059	0.0051	0.0044
Leishmania major	hypothetical protein, conserved	0.0059	0.0051	0.356
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.005	0.0028	0.0021
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.005	0.0028	0.0011
Brugia malayi	SRC-1	0.005	0.0028	0.0021
Entamoeba histolytica	hypothetical protein, conserved	0.0059	0.0051	0.0157
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0059	0.0051	0.0053
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0021
Schistosoma mansoni	protein kinase	0.0065	0.0068	0.0052
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.005	0.0028	0.0021
Echinococcus multilocularis	Pleckstrin y	0.0059	0.0051	0.0053
Loa Loa (eye worm)	PH domain-containing protein	0.0059	0.0051	0.0044
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0021
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0021
Echinococcus granulosus	tyrosine kinase	0.005	0.0028	0.0025
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0059	0.0051	0.0053
Leishmania major	protein kinase, putative	0.0075	0.0094	1
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0075	0.0092	0.9675
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0051	0.0333
Echinococcus multilocularis	activated cdc42 kinase 1	0.005	0.0028	0.0025
Schistosoma mansoni	protein kinase	0.0075	0.0094	0.0078
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0075	0.0092	0.9675
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0059	0.0051	0.0053
Brugia malayi	Dynamin	0.0059	0.0051	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0051	0.0044
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.005	0.0028	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Echinococcus granulosus	retinal guanylyl cyclase 2	0.005	0.0028	0.0025
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.005	0.0028	0.0025
Echinococcus granulosus	tyrosine protein kinase HCK	0.005	0.0028	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0148	0.028	0.0274
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.005	0.0028	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Brugia malayi	PH domain containing protein	0.0059	0.0051	0.0044
Leishmania major	serine/threonine-protein kinase a, putative	0.0075	0.0092	0.9675
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0051	0.0044
Entamoeba histolytica	protein kinase domain containing protein	0.0065	0.0068	0.0269
Echinococcus granulosus	c src tyrosine kinase	0.005	0.0028	0.0025
Entamoeba histolytica	hypothetical protein	0.064	0.1538	1
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0075	0.0094	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.005	0.0028	0.0025
Loa Loa (eye worm)	oxysterol binding protein	0.0059	0.0051	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0051	0.0044
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.005	0.0028	0.0025
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0059	0.0051	0.356
Trichomonas vaginalis	CAMK family protein kinase	0.005	0.0028	0.018
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.005	0.0028	0.018
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0059	0.0051	0.0044
Loa Loa (eye worm)	hypothetical protein	0.005	0.0028	0.0021
Echinococcus multilocularis	tyrosine protein kinase	0.005	0.0028	0.0025
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.008	0.0105	0.0089
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Schistosoma mansoni	dynamin	0.0059	0.0051	0.0035
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0059	0.0051	0.0053
Echinococcus multilocularis	tyrosine protein kinase pr2	0.005	0.0028	0.0025
Echinococcus granulosus	epidermal growth factor receptor	0.005	0.0028	0.0025
Echinococcus granulosus	pleckstrin y domain containing family A	0.0059	0.0051	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.064	0.1538	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.005	0.0028	0.0011
Echinococcus granulosus	Rho GTPase activating protein 24	0.0059	0.0051	0.0053
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0059	0.0051	0.0053
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.005	0.0028	0.0025
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0129	0.0232	0.0225
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0059	0.0051	0.0333
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0059	0.0051	0.0053
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0051	0.0333
Loa Loa (eye worm)	TK protein kinase	0.005	0.0028	0.0021
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.005	0.0028	0.0025
Loa Loa (eye worm)	TK/FAK protein kinase	0.005	0.0028	0.0021
Schistosoma mansoni	regulator of G protein signaling	0.064	0.1538	0.1524
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0059	0.0051	0.0124
Schistosoma mansoni	protein tyrosine kinase	0.005	0.0028	0.0011
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0051	0.0333
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0021
Echinococcus multilocularis	cytohesin 1	0.0059	0.0051	0.0053
Echinococcus multilocularis	oxysterol binding protein 1	0.0059	0.0051	0.0053
Echinococcus multilocularis	axis inhibition protein axin	0.064	0.1538	0.1833
Echinococcus multilocularis	protein kinase	0.005	0.0028	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Brugia malayi	Protein kinase domain containing protein	0.005	0.0028	0.0021
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.028	0.1822
Echinococcus multilocularis	beta adrenergic receptor kinase	0.3028	0.7642	0.9138
Brugia malayi	Sema domain containing protein	0.0339	0.0767	0.076
Schistosoma mansoni	tyrosine kinase	0.005	0.0028	0.0011
Toxoplasma gondii	AtPH1 family protein	0.0059	0.0051	0.356
Entamoeba histolytica	hypothetical protein	0.0148	0.028	0.1673
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0075	0.0094	1
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0075	0.0094	0.044
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0075	0.0092	0.0426
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0059	0.0051	0.0157
Trichomonas vaginalis	conserved hypothetical protein	0.064	0.1538	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.005	0.0028	0.0025
Loa Loa (eye worm)	TK/EGFR protein kinase	0.005	0.0028	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0051	0.0044
Entamoeba histolytica	hypothetical protein	0.0059	0.0051	0.0157
Brugia malayi	Oxysterol binding protein	0.0059	0.0051	0.0044
Loa Loa (eye worm)	TK/FER protein kinase	0.005	0.0028	0.0021
Echinococcus granulosus	protein kinase	0.005	0.0028	0.0025
Schistosoma mansoni	hypothetical protein	0.0059	0.0051	0.0035
Brugia malayi	Plekhf2 protein	0.0059	0.0051	0.0044
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0148	0.028	0.1822
Entamoeba histolytica	protein kinase domain containing protein	0.0075	0.0094	0.044
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Schistosoma mansoni	hypothetical protein	0.0148	0.028	0.0264
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Loa Loa (eye worm)	hypothetical protein	0.008	0.0105	0.0098
Brugia malayi	PH domain containing protein	0.0059	0.0051	0.0044
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0028	0.0011
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0094	0.0612
Brugia malayi	hypothetical protein	0.0085	0.0118	0.0111
Entamoeba histolytica	hypothetical protein	0.0059	0.0051	0.0157
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0059	0.0051	0.0053
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0075	0.0092	0.0426
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0051	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0051	0.0044
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Echinococcus granulosus	Oxysterol binding protein 11	0.0059	0.0051	0.0053
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0092	0.0598
Trichomonas vaginalis	TKL family protein kinase	0.005	0.0028	0.018
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0059	0.0051	0.356

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC80 (functional)	= 0.0156 ug ml-1	Antimicrobial activity against Candida albicans by micro-broth dilution method	ChEMBL.	19231179
MIC80 (functional)	= 0.25 ug ml-1	Antimicrobial activity against Cryptococcus neoformans by micro-broth dilution method	ChEMBL.	19231179

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL475975

Bibliographic References

No literature references available for this target.

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Detailed information for compound 981135