Detailed information for compound 981587

Basic information

Technical information
  • TDR Targets ID: 981587
  • Name: [7-[(E)-5-[(1S,4aS,8aS)-5,5,8a-trimethyl-2-me thylidene-3,4,4a,6,7,8-hexahydro-1H-naphthale n-1-yl]-3-methylpent-2-enyl]-9-methylpurin-9- ium-6-yl]-methoxyazanide
  • MW: 457.695 | Formula: C27H47N5O
  • H donors: 1 H acceptors: 0 LogP: 6.81 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO/N=C/1\[N-]CNC2C1N(C/C=C(/CC[C@H]1C(=C)CC[C@@H]3[C@]1(C)CCCC3(C)C)\C)C[NH+]2C
  • InChi: 1S/C27H41N5O/c1-19(13-16-32-18-31(6)25-23(32)24(30-33-7)28-17-29-25)9-11-21-20(2)10-12-22-26(3,4)14-8-15-27(21,22)5/h13,17-18,21-22H,2,8-12,14-16H2,1,3-7H3/b19-13+/t21-,22-,27+/m0/s1
  • InChiKey: VJQNJJUTVWMRBO-MZBNONOLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [7-[(E)-5-[(1S,4aS,8aS)-5,5,8a-trimethyl-2-methylene-decalin-1-yl]-3-methyl-pent-2-enyl]-9-methyl-purin-9-ium-6-yl]-methoxy-azanide
  • [7-[(E)-5-[(1S,4aS,8aS)-5,5,8a-trimethyl-2-methylene-1-decalinyl]-3-methylpent-2-enyl]-9-methyl-6-purin-9-iumyl]-methoxyazanide
  • [7-[(E)-5-[(1S,4aS,8aS)-5,5,8a-trimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]-3-methyl-pent-2-enyl]-9-methyl-purin-9-ium-6-yl]-methoxy-azanide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis regulator of G protein signaling 3 0.0812 0.1556 0.1855
Plasmodium falciparum serine/threonine protein kinase, putative 0.008 0.0084 0.6014
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1507 0.2957 0.3531
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0074 0.0072 0.4445
Echinococcus granulosus Pleckstrin y 0.0074 0.0072 0.008
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Brugia malayi serine/threonine kinase 12 0.008 0.0084 0.0078
Brugia malayi Syntrophin-1 0.0074 0.0072 0.0067
Echinococcus granulosus tyrosine protein kinase HCK 0.0058 0.004 0.0042
Entamoeba histolytica protein kinase domain containing protein 0.0221 0.0367 0.2156
Echinococcus multilocularis plexin a4 0.1036 0.2008 0.2396
Echinococcus multilocularis oxysterol binding protein 3 0.0074 0.0072 0.008
Loa Loa (eye worm) hypothetical protein 0.0074 0.0072 0.0067
Trichomonas vaginalis centaurin beta, putative 0.0074 0.0072 0.0465
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0078 0.008 0.009
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Echinococcus granulosus tyrosine protein kinase Fyn 0.0058 0.004 0.0042
Loa Loa (eye worm) hypothetical protein 0.0058 0.004 0.0035
Loa Loa (eye worm) hypothetical protein 0.0058 0.004 0.0035
Loa Loa (eye worm) hypothetical protein 0.0371 0.0669 0.0664
Entamoeba histolytica hypothetical protein 0.0162 0.0249 0.138
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Loa Loa (eye worm) hypothetical protein 0.0812 0.1556 0.1552
Loa Loa (eye worm) hypothetical protein 0.0074 0.0072 0.0067
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.5005 1 1
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0812 0.1556 1
Brugia malayi Dynamin 0.0074 0.0072 0.0067
Echinococcus multilocularis Pleckstrin y 0.0074 0.0072 0.008
Trichomonas vaginalis AGC family protein kinase 0.008 0.0084 0.0539
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Echinococcus granulosus serine:threonine protein kinase 12 B 0.008 0.0084 0.0094
Leishmania major protein kinase, putative 0.0094 0.0113 1
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0094 0.0113 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0072 0.0067
Echinococcus granulosus G protein coupled receptor kinase 1 0.3025 0.6013 0.7186
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0074 0.0072 0.0465
Brugia malayi PH domain containing protein 0.0074 0.0072 0.0067
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.008 0.0266
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0058 0.004 0.0042
Echinococcus multilocularis beta 1 syntrophin 0.0074 0.0072 0.008
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0058 0.004 0.0042
Echinococcus multilocularis c src tyrosine kinase 0.0058 0.004 0.0042
Loa Loa (eye worm) TK protein kinase 0.0058 0.004 0.0035
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0058 0.004 0.0042
Schistosoma mansoni regulator of G protein signaling 0.0812 0.1556 0.1545
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0072 0.0465
Trichomonas vaginalis centaurin/arf, putative 0.0074 0.0072 0.0465
Loa Loa (eye worm) hypothetical protein 0.0812 0.1556 0.1552
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0058 0.004 0.0035
Echinococcus multilocularis protein kinase 0.0058 0.004 0.0042
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0094 0.0113 1
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0074 0.0072 0.0213
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0074 0.0072 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0249 0.1603
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Loa Loa (eye worm) sema domain-containing protein 0.0371 0.0669 0.0664
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0208 0.0341 0.0336
Loa Loa (eye worm) hypothetical protein 0.0371 0.0669 0.0664
Echinococcus granulosus regulator of G protein signaling 7 0.0812 0.1556 0.1855
Onchocerca volvulus 0.0074 0.0072 0.0196
Echinococcus granulosus tyrosine protein kinase pr2 0.0058 0.004 0.0042
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Loa Loa (eye worm) hypothetical protein 0.0058 0.004 0.0035
Trypanosoma cruzi PH domain containing protein, putative 0.0074 0.0072 0.4445
Schistosoma mansoni ephrin receptor 0.0058 0.004 0.0027
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0058 0.004 0.0042
Loa Loa (eye worm) hypothetical protein 0.0074 0.0072 0.0067
Trichomonas vaginalis centaurin gamma, putative 0.0074 0.0072 0.0465
Echinococcus multilocularis tyrosine protein kinase Blk 0.0058 0.004 0.0042
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0058 0.004 0.0027
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Trypanosoma cruzi hypothetical protein 0.0074 0.0072 0.4445
Echinococcus granulosus beta 1 syntrophin 0.0074 0.0072 0.008
Loa Loa (eye worm) TK/FAK protein kinase 0.0058 0.004 0.0035
Schistosoma mansoni serine/threonine RGC 0.0058 0.004 0.0027
Schistosoma mansoni protein kinase 0.0078 0.008 0.0068
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0058 0.004 0.0258
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0094 0.0113 0.0724
Loa Loa (eye worm) hypothetical protein 0.0058 0.004 0.0035
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0074 0.0072 0.008
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.004 0.0035
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Brugia malayi bone morphogenetic protein type 1 receptor 0.0058 0.004 0.0035
Schistosoma mansoni protein kinase 0.0058 0.004 0.0027
Trypanosoma brucei PH domain containing protein, putative 0.0074 0.0072 0.4445
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Loa Loa (eye worm) RGC/RGC protein kinase 0.0058 0.004 0.0035
Trypanosoma cruzi aurora B kinase, putative 0.008 0.0084 0.6014
Schistosoma mansoni protein kinase 0.008 0.0084 0.0071
Echinococcus multilocularis pdz domain containing protein 0.0074 0.0072 0.008
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Loa Loa (eye worm) hypothetical protein 0.0074 0.0072 0.0067
Echinococcus granulosus tyrosine protein kinase 0.0058 0.004 0.0042
Brugia malayi hypothetical protein 0.0058 0.004 0.0035
Echinococcus multilocularis cytohesin 1 0.0074 0.0072 0.008
Loa Loa (eye worm) hypothetical protein 0.0058 0.004 0.0035
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Echinococcus multilocularis oxysterol binding protein 1 0.0074 0.0072 0.008
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Loa Loa (eye worm) hypothetical protein 0.0074 0.0072 0.0067
Brugia malayi serine/threonine protein kinase 6 0.008 0.0084 0.0078
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0058 0.004 0.0258
Entamoeba histolytica p21-activated kinase 0.0094 0.0113 0.0478
Echinococcus granulosus Pleckstrin y 0.0074 0.0072 0.008
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Brugia malayi Variant SH3 domain containing protein 0.0074 0.0072 0.0067
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0058 0.004 0.0258
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0058 0.004 0.0042
Echinococcus multilocularis transcription factor collier 0.0162 0.0249 0.0292
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.004 0.0035
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Schistosoma mansoni axis inhibition protein axin 0.0812 0.1556 0.1545
Echinococcus multilocularis tyrosine protein kinase 0.0058 0.004 0.0042
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0058 0.004 0.0042
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0074 0.0072 0.0213
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0058 0.004 0.0042
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0074 0.0072 0.0213
Schistosoma mansoni serine/threonine protein kinase 0.3837 0.7647 0.7644
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Echinococcus granulosus tyrosine kinase 0.0058 0.004 0.0042
Loa Loa (eye worm) AUR protein kinase 0.008 0.0084 0.0078
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Loa Loa (eye worm) serine/threonine protein kinase 0.0058 0.004 0.0035
Echinococcus multilocularis regulator of G protein signaling 7 0.0812 0.1556 0.1855
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0074 0.0072 0.0067
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Loa Loa (eye worm) hypothetical protein 0.0058 0.004 0.0035
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.004 0.0035
Echinococcus multilocularis tyrosine protein kinase pr2 0.0058 0.004 0.0042
Echinococcus granulosus insulin receptor 0.0058 0.004 0.0042
Onchocerca volvulus 0.0074 0.0072 0.0196
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.004 0.0035
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.5005 1 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0058 0.004 0.0042
Brugia malayi regulator of G-protein signaling rgs-7 0.0812 0.1556 0.1552
Schistosoma mansoni goodpasture antigen-binding protein 0.0074 0.0072 0.0059
Trypanosoma brucei rac serine-threonine kinase, putative 0.0094 0.0113 1
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0072 0.0465
Brugia malayi SH2 domain containing protein 0.0058 0.004 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0072 0.0465
Echinococcus multilocularis roundabout 2 0.0154 0.0234 0.0273
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0074 0.0072 0.0067
Schistosoma mansoni hypothetical protein 0.0058 0.004 0.0027
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0094 0.0113 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0058 0.004 0.0042
Entamoeba histolytica hypothetical protein, conserved 0.0074 0.0072 0.0213
Echinococcus granulosus tyrosine protein kinase csk 0.0058 0.004 0.0042
Echinococcus multilocularis aurora kinase A 0.008 0.0084 0.0094
Loa Loa (eye worm) hypothetical protein 0.0162 0.0249 0.0244
Schistosoma mansoni tyrosine protein kinase 0.0058 0.004 0.0027
Entamoeba histolytica protein kinase, putative 0.0094 0.0113 0.0478
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0074 0.0072 0.0067
Schistosoma mansoni regulator of G protein signaling 0.0812 0.1556 0.1545
Trichomonas vaginalis conserved hypothetical protein 0.0812 0.1556 1
Loa Loa (eye worm) TK protein kinase 0.0058 0.004 0.0035
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Echinococcus multilocularis Immunoglobulin 0.0136 0.0197 0.0229
Brugia malayi PH domain containing protein 0.0074 0.0072 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Loa Loa (eye worm) sema domain-containing protein 0.0371 0.0669 0.0664
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.3837 0.7647 0.7646
Brugia malayi plexin A 0.1036 0.2008 0.2004
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Loa Loa (eye worm) hypothetical protein 0.0371 0.0669 0.0664
Loa Loa (eye worm) hypothetical protein 0.0225 0.0375 0.037
Echinococcus multilocularis regulator of G protein signaling 0.0812 0.1556 0.1855
Schistosoma mansoni hypothetical protein 0.0162 0.0249 0.0237
Onchocerca volvulus Protein melted homolog 0.0074 0.0072 0.0196
Entamoeba histolytica ARF GTPase activating protein, putative 0.0074 0.0072 0.0213
Loa Loa (eye worm) hypothetical protein 0.0162 0.0249 0.0244
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0058 0.004 0.0042
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Trypanosoma cruzi NIMA-related kinase, putative 0.0094 0.0113 1
Plasmodium falciparum protein kinase, putative 0.0078 0.008 0.5555
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0812 0.1556 0.1545
Plasmodium falciparum calcium-dependent protein kinase 7 0.0094 0.0113 1
Trypanosoma brucei protein kinase, putative 0.0078 0.008 0.5555
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0074 0.0072 0.4445
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0162 0.0249 0.1603
Toxoplasma gondii hypothetical protein 0.0074 0.0072 0.4445
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Echinococcus granulosus Immunoglobulin 0.0136 0.0197 0.0229
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0094 0.0113 1
Schistosoma mansoni protein kinase 0.0058 0.004 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.004 0.0027
Loa Loa (eye worm) hypothetical protein 0.0074 0.0072 0.0067
Brugia malayi Plekhf2 protein 0.0074 0.0072 0.0067
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0074 0.0072 0.0213
Loa Loa (eye worm) hypothetical protein 0.0141 0.0207 0.0202
Echinococcus granulosus regulator of G protein signaling 3 0.0812 0.1556 0.1855
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0058 0.004 0.0042
Echinococcus granulosus natriuretic peptide receptor 1 0.0058 0.004 0.0042
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0094 0.0113 1
Leishmania major serine/threonine-protein kinase a, putative 0.0094 0.0113 1
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Echinococcus multilocularis axis inhibition protein axin 0.0812 0.1556 0.1855
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Entamoeba histolytica hypothetical protein 0.0812 0.1556 1
Entamoeba histolytica hypothetical protein 0.0094 0.0113 0.0478
Echinococcus multilocularis FL cytokine receptor 0.0058 0.004 0.0042
Brugia malayi Protein kinase domain containing protein 0.0094 0.0113 0.0107
Entamoeba histolytica PH domain containing protein kinase, putative 0.0094 0.0113 0.0478
Loa Loa (eye worm) RGC/RGC protein kinase 0.0058 0.004 0.0035
Schistosoma mansoni protein kinase 0.0058 0.004 0.0027
Schistosoma mansoni vesicular amine transporter 0.0139 0.0202 0.0189
Onchocerca volvulus 0.0074 0.0072 0.0196
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Brugia malayi Protein kinase domain containing protein 0.0314 0.0555 0.055
Loa Loa (eye worm) SRC-1 0.0058 0.004 0.0035
Entamoeba histolytica protein kinase , putative 0.008 0.0084 0.0288
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0058 0.004 0.0042
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Echinococcus granulosus neuroglian 0.0136 0.0197 0.0229
Echinococcus granulosus regulator of G protein signaling 3 0.0812 0.1556 0.1855
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0074 0.0072 0.4445
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0162 0.0249 0.1603
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Echinococcus multilocularis exocyst complex component 2 0.0162 0.0249 0.0292
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Echinococcus granulosus protein tyrosine kinase 0.0058 0.004 0.0042
Onchocerca volvulus outspread protein homolog 0.0074 0.0072 0.0196
Echinococcus multilocularis tyrosine protein kinase HCK 0.0058 0.004 0.0042
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0058 0.004 0.0042
Echinococcus granulosus DCC interacting protein 13 beta 0.0074 0.0072 0.008
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.004 0.0035
Loa Loa (eye worm) hypothetical protein 0.0503 0.0935 0.093
Loa Loa (eye worm) hypothetical protein 0.0874 0.1681 0.1677
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Echinococcus granulosus axis inhibition protein axin 0.0812 0.1556 0.1855
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0072 0.0465
Echinococcus multilocularis GRB2 associated binding protein 3 0.0074 0.0072 0.008
Loa Loa (eye worm) hypothetical protein 0.0058 0.004 0.0035
Echinococcus granulosus Regulator of G protein signaling 20 0.0812 0.1556 0.1855
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0058 0.004 0.0042
Loa Loa (eye worm) hypothetical protein 0.0074 0.0072 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.3837 0.7647 0.7644
Brugia malayi serine/threonine-protein kinase 6 0.008 0.0084 0.0078
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0058 0.004 0.0035
Loa Loa (eye worm) hypothetical protein 0.0149 0.0223 0.0218
Brugia malayi Sema domain containing protein 0.0371 0.0669 0.0664
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Brugia malayi Uncoordinated protein 104 0.0074 0.0072 0.0067
Schistosoma mansoni fibrocystin l 0.0162 0.0249 0.0237
Entamoeba histolytica protein kinase, putative 0.008 0.0084 0.0288
Echinococcus granulosus tyrosine protein kinase Fyn 0.0058 0.004 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0072 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0249 0.1603
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Loa Loa (eye worm) hypothetical protein 0.0074 0.0072 0.0067
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0074 0.0072 0.0213
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0058 0.004 0.0042
Loa Loa (eye worm) hypothetical protein 0.0812 0.1556 0.1552
Schistosoma mansoni plexin 0.0503 0.0935 0.0923
Echinococcus granulosus fibroblast growth factor receptor 4 0.0058 0.004 0.0042
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Echinococcus granulosus roundabout 2 0.0154 0.0234 0.0273
Trichomonas vaginalis conserved hypothetical protein 0.0812 0.1556 1
Echinococcus granulosus expressed protein 0.0812 0.1556 0.1855
Brugia malayi Cadps2 protein 0.0074 0.0072 0.0067
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0074 0.0072 0.0067
Echinococcus multilocularis neuroglian 0.0136 0.0197 0.0229
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0058 0.004 0.0035
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Plasmodium vivax PH domain containing protein 0.0074 0.0072 0.4445
Plasmodium falciparum PH domain-containing protein, putative 0.0074 0.0072 0.4445
Trichomonas vaginalis protein transport protein sec7, putative 0.0074 0.0072 0.0465
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0136 0.0197 0.0184
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.004 0.0027
Loa Loa (eye worm) hypothetical protein 0.0074 0.0072 0.0067
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0074 0.0072 0.008
Echinococcus multilocularis protein tyrosine kinase 0.0058 0.004 0.0042
Echinococcus multilocularis dynamin 1 0.0074 0.0072 0.008
Plasmodium falciparum oxysterol-binding protein, putative 0.0074 0.0072 0.4445
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0058 0.004 0.0035
Brugia malayi Immunoglobulin I-set domain containing protein 0.0141 0.0207 0.0202
Brugia malayi Oxysterol binding protein 0.0074 0.0072 0.0067
Leishmania major hypothetical protein, conserved 0.0074 0.0072 0.4445
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Schistosoma mansoni oxysterol-binding protein 1 0.0074 0.0072 0.0059
Schistosoma mansoni regulator of G protein signaling 0.0812 0.1556 0.1545
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.4194 0.8366 1
Loa Loa (eye worm) AUR protein kinase 0.008 0.0084 0.0078
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0074 0.0072 0.0067
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Echinococcus granulosus oxysterol binding protein 3 0.0074 0.0072 0.008
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Loa Loa (eye worm) AGC/AKT protein kinase 0.0094 0.0113 0.0107
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0074 0.0072 0.0465
Echinococcus multilocularis protein kinase 0.0058 0.004 0.0042
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.004 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Brugia malayi IPT/TIG domain containing protein 0.0162 0.0249 0.0244
Brugia malayi hypothetical protein 0.0058 0.004 0.0035
Echinococcus multilocularis G protein coupled receptor kinase 1 0.3025 0.6013 0.7186
Trypanosoma cruzi hypothetical protein 0.0074 0.0072 0.4445
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0058 0.004 0.0035
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Echinococcus granulosus tyrosine protein kinase csk 0.0058 0.004 0.0042
Echinococcus multilocularis transfer RNA-Thr 0.0058 0.004 0.0042
Schistosoma mansoni protein kinase 0.0058 0.004 0.0027
Loa Loa (eye worm) TK/DDR protein kinase 0.0058 0.004 0.0035
Schistosoma mansoni rho gtpase activating protein 0.0074 0.0072 0.0059
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0074 0.0072 0.008
Brugia malayi Regulator of G protein signaling domain containing protein 0.0812 0.1556 0.1552
Brugia malayi Immunoglobulin I-set domain containing protein 0.0208 0.0341 0.0336
Schistosoma mansoni protein kinase 0.0078 0.008 0.0068
Schistosoma mansoni plexin 0.0874 0.1681 0.167
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.004 0.0035
Echinococcus multilocularis rac serine:threonine kinase 0.0094 0.0113 0.0128
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0812 0.1556 0.1545
Loa Loa (eye worm) hypothetical protein 0.0074 0.0072 0.0067
Echinococcus granulosus Rho GTPase activating protein 24 0.0074 0.0072 0.008
Echinococcus granulosus axis inhibition protein axin 0.0812 0.1556 0.1855
Loa Loa (eye worm) hypothetical protein 0.0074 0.0072 0.0067
Schistosoma mansoni hypothetical protein 0.0371 0.0669 0.0657
Echinococcus granulosus tyrosine protein kinase Lyn 0.0078 0.008 0.009
Echinococcus granulosus Oxysterol binding protein 11 0.0074 0.0072 0.008
Brugia malayi PH domain containing protein 0.0074 0.0072 0.0067
Entamoeba histolytica PH domain containing protein 0.0074 0.0072 0.0213
Trichomonas vaginalis AGC family protein kinase 0.0058 0.004 0.0258
Loa Loa (eye worm) hypothetical protein 0.0058 0.004 0.0035
Echinococcus granulosus tyrosine kinase 0.0058 0.004 0.0042
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0058 0.004 0.0042
Echinococcus multilocularis calcium dependent secretion activator 1 0.0074 0.0072 0.008
Echinococcus multilocularis Ras associated and pleckstrin y 0.0074 0.0072 0.008
Echinococcus multilocularis G protein coupled receptor kinase 6 0.4194 0.8366 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0058 0.004 0.0035
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.4194 0.8366 0.8365
Trypanosoma brucei protein kinase, putative 0.0094 0.0113 1
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.004 0.0035
Schistosoma mansoni growth factor receptor-bound protein 0.0074 0.0072 0.0059
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0074 0.0072 0.0067
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0058 0.004 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0249 0.1603
Brugia malayi hypothetical protein 0.0812 0.1556 0.1552
Entamoeba histolytica cell surface protease gp63, putative 0.0162 0.0249 0.138
Entamoeba histolytica hypothetical protein 0.0074 0.0072 0.0213
Loa Loa (eye worm) hypothetical protein 0.0074 0.0072 0.0067
Brugia malayi Pleckstrin Homology Domain 0.0074 0.0072 0.0067
Brugia malayi protein-tyrosine kinase 0.0058 0.004 0.0035
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0058 0.004 0.0042
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0058 0.004 0.0042
Echinococcus multilocularis tyrosine protein kinase csk 0.0058 0.004 0.0042
Brugia malayi hypothetical protein 0.0812 0.1556 0.1552
Echinococcus granulosus cytohesin 1 0.0074 0.0072 0.008
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Echinococcus granulosus GRB2 associated binding protein 3 0.0074 0.0072 0.008
Loa Loa (eye worm) hypothetical protein 0.0058 0.004 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.004 0.0258
Echinococcus multilocularis tyrosine protein kinase csk 0.0058 0.004 0.0042
Echinococcus multilocularis DCC interacting protein 13 beta 0.0074 0.0072 0.008
Echinococcus multilocularis protein KINase family member (kin 25) 0.0058 0.004 0.0042
Echinococcus granulosus integrin linked protein kinase 0.0058 0.004 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.004 0.0258
Brugia malayi probable spectrin beta chain 0.0074 0.0072 0.0067
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0058 0.004 0.0035
Schistosoma mansoni hypothetical protein 0.0074 0.0072 0.0059
Plasmodium vivax serine/threonine protein kinase 6, putative 0.008 0.0084 0.6014
Echinococcus multilocularis Regulator of G protein signaling 20 0.0812 0.1556 0.1855
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0058 0.004 0.0027
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Brugia malayi A-kinase anchor protein 10, precursor 0.0812 0.1556 0.1552
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0058 0.004 0.0042
Echinococcus granulosus activated cdc42 kinase 1 0.0058 0.004 0.0042
Loa Loa (eye worm) rho-GTPase-activating 0.0074 0.0072 0.0067
Echinococcus multilocularis actin binding protein anillin 0.0074 0.0072 0.008
Schistosoma mansoni hypothetical protein 0.0074 0.0072 0.0059
Loa Loa (eye worm) hypothetical protein 0.0371 0.0669 0.0664
Leishmania major folate/biopterin transporter, putative 0.0094 0.0113 1
Echinococcus granulosus defective proboscis extension response 0.0136 0.0197 0.0229
Loa Loa (eye worm) hypothetical protein 0.0074 0.0072 0.0067
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0074 0.0072 0.0059
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0094 0.0113 1
Onchocerca volvulus 0.0074 0.0072 0.0196
Schistosoma mansoni serine/threonine-protein kinase 0.0094 0.0113 0.01
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Schistosoma mansoni cell adhesion molecule 0.0154 0.0234 0.0221
Echinococcus granulosus tyrosine protein kinase Src42A 0.0058 0.004 0.0042
Loa Loa (eye worm) TK protein kinase 0.0058 0.004 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Echinococcus granulosus retinal guanylyl cyclase 2 0.0058 0.004 0.0042
Trypanosoma cruzi PH domain containing protein, putative 0.0074 0.0072 0.4445
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0094 0.0113 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0074 0.0072 0.4445
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.004 0.0258
Echinococcus granulosus oxysterol binding protein 1 0.0074 0.0072 0.008
Brugia malayi Tyrosine-protein kinase PR2 0.0058 0.004 0.0035
Echinococcus granulosus plexin a4 0.1036 0.2008 0.2396
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0058 0.004 0.0042
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.004 0.0027
Echinococcus multilocularis ephrin type A receptor 4 A 0.0058 0.004 0.0042
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0058 0.004 0.0042
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0149 0.0223 0.026
Toxoplasma gondii Oxysterol-binding protein 0.0074 0.0072 0.4445
Loa Loa (eye worm) hypothetical protein 0.0058 0.004 0.0035
Trichomonas vaginalis alpha chimerin, putative 0.0074 0.0072 0.0465
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0074 0.0072 0.008
Schistosoma mansoni protein kinase 0.0058 0.004 0.0027
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0812 0.1556 0.1855
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Echinococcus multilocularis regulator of G protein signaling 7 0.0812 0.1556 0.1855
Trichomonas vaginalis protein kinase atn1, putative 0.0058 0.004 0.0258
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0078 0.008 0.5555
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0084 0.0071
Echinococcus granulosus semaphorin 5B 0.0371 0.0669 0.0793
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0074 0.0072 0.4445
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0074 0.0072 0.0213
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0058 0.004 0.0042
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0162 0.0249 0.1603
Echinococcus granulosus tyrosine protein kinase ABL1 0.0058 0.004 0.0042
Loa Loa (eye worm) Plekhf2 protein 0.0074 0.0072 0.0067
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0094 0.0113 1
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Loa Loa (eye worm) hypothetical protein 0.0812 0.1556 0.1552
Echinococcus granulosus regulator of G protein signaling 7 0.0812 0.1556 0.1855
Echinococcus granulosus exocyst complex component 2 0.0162 0.0249 0.0292
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Echinococcus multilocularis kinase suppressor of Ras 1 0.0058 0.004 0.0042
Brugia malayi SRC-1 0.0058 0.004 0.0035
Brugia malayi hypothetical protein 0.0058 0.004 0.0035
Echinococcus multilocularis receptor type guanylyl cyclase 0.0058 0.004 0.0042
Trypanosoma cruzi hypothetical protein 0.0074 0.0072 0.4445
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0136 0.0197 0.0229
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Loa Loa (eye worm) RGC/RGC protein kinase 0.0058 0.004 0.0035
Loa Loa (eye worm) RGS-3 protein 0.0812 0.1556 0.1552
Brugia malayi PH domain containing protein 0.0074 0.0072 0.0067
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0074 0.0072 0.4445
Echinococcus granulosus transcription factor collier 0.0162 0.0249 0.0292
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Brugia malayi Immunoglobulin I-set domain containing protein 0.0058 0.004 0.0035
Trichomonas vaginalis STE family protein kinase 0.0058 0.004 0.0258
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0058 0.004 0.0042
Brugia malayi C-terminal src kinase protein 1 0.0058 0.004 0.0035
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0094 0.0113 1
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Brugia malayi PXA domain containing protein 0.0812 0.1556 0.1552
Loa Loa (eye worm) TK/EGFR protein kinase 0.0058 0.004 0.0035
Schistosoma mansoni goodpasture antigen-binding protein 0.0074 0.0072 0.0059
Schistosoma mansoni protein kinase 0.0078 0.008 0.0068
Echinococcus granulosus activin receptor type 0.0078 0.008 0.009
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Echinococcus granulosus kinase suppressor of Ras 1 0.0058 0.004 0.0042
Echinococcus multilocularis integrin linked protein kinase 0.0058 0.004 0.0042
Echinococcus multilocularis tyrosine kinase 0.0058 0.004 0.0042
Trypanosoma cruzi hypothetical protein 0.0074 0.0072 0.4445
Schistosoma mansoni ephrin receptor 0.0064 0.0051 0.0038
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Leishmania major protein kinase, putative 0.0094 0.0113 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0058 0.004 0.0035
Brugia malayi Sema domain containing protein 0.0371 0.0669 0.0664
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0058 0.004 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0072 0.0465
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.4194 0.8366 0.8365
Echinococcus multilocularis heat shock protein 70 0.0058 0.004 0.0042
Loa Loa (eye worm) syntrophin-1 0.0074 0.0072 0.0067
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0074 0.0072 0.0196
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Echinococcus multilocularis beta adrenergic receptor kinase 0.3837 0.7647 0.914
Onchocerca volvulus 0.0074 0.0072 0.0196
Brugia malayi hypothetical protein 0.0074 0.0072 0.0067
Brugia malayi Regulator of G protein signaling domain containing protein 0.0812 0.1556 0.1552
Entamoeba histolytica hypothetical protein 0.0074 0.0072 0.0213
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0058 0.004 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.004 0.0258
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0074 0.0072 0.008
Loa Loa (eye worm) hypothetical protein 0.0149 0.0223 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0074 0.0072 0.0059
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Entamoeba histolytica PH domain containing protein 0.0074 0.0072 0.0213
Brugia malayi PH domain containing protein 0.0074 0.0072 0.0067
Echinococcus multilocularis Oxysterol binding protein 11 0.0074 0.0072 0.008
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0074 0.0072 0.4445
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Brugia malayi hypothetical protein 0.0371 0.0669 0.0664
Schistosoma mansoni protein tyrosine kinase 0.0058 0.004 0.0027
Schistosoma mansoni syntrophin 0.0074 0.0072 0.0059
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0058 0.004 0.0027
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0074 0.0072 0.0465
Echinococcus multilocularis Pleckstrin y 0.0074 0.0072 0.008
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0058 0.004 0.0042
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0058 0.004 0.0027
Loa Loa (eye worm) hypothetical protein 0.0371 0.0669 0.0664
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0074 0.0072 0.008
Echinococcus granulosus serine/threonine protein kinase 0.0094 0.0113 0.0128
Echinococcus granulosus activated cdc42 kinase 1 0.0058 0.004 0.0042
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0074 0.0072 0.4445
Brugia malayi PH domain containing protein 0.0074 0.0072 0.0067
Echinococcus granulosus pdz domain containing protein 0.0074 0.0072 0.008
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.004 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Schistosoma mansoni zinc finger protein 0.0074 0.0072 0.0059
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Brugia malayi hypothetical protein 0.0371 0.0669 0.0664
Schistosoma mansoni dynamin 0.0074 0.0072 0.0059
Trypanosoma cruzi PH domain containing protein, putative 0.0074 0.0072 0.4445
Trichomonas vaginalis conserved hypothetical protein 0.0812 0.1556 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.004 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Entamoeba histolytica protein kinase, putative 0.008 0.0084 0.0288
Echinococcus multilocularis epidermal growth factor receptor 0.0058 0.004 0.0042
Echinococcus multilocularis axis inhibition protein axin 0.0812 0.1556 0.1855
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0094 0.0113 1
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.4194 0.8366 0.8365
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0094 0.0113 1
Trichomonas vaginalis protein transport protein sec7, putative 0.0074 0.0072 0.0465
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.008 0.0084 0.0288
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0812 0.1556 0.1552
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0812 0.1556 1
Giardia lamblia Aurora kinase 0.008 0.0084 1
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Entamoeba histolytica protein kinase, putative 0.0094 0.0113 0.0478
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0074 0.0072 0.0213
Echinococcus multilocularis insulin receptor 0.0058 0.004 0.0042
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0058 0.004 0.0042
Loa Loa (eye worm) TK/ACK protein kinase 0.0058 0.004 0.0035
Loa Loa (eye worm) TK/ALK protein kinase 0.0314 0.0555 0.0549
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Echinococcus multilocularis activin receptor type 0.0078 0.008 0.009
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0058 0.004 0.0042
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0074 0.0072 0.0213
Schistosoma mansoni hypothetical protein 0.0074 0.0072 0.0059
Loa Loa (eye worm) hypothetical protein 0.0074 0.0072 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0249 0.1603
Leishmania major protein kinase, putative 0.0078 0.008 0.5555
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Trypanosoma cruzi hypothetical protein 0.0074 0.0072 0.4445
Schistosoma mansoni protein kinase 0.0058 0.004 0.0027
Schistosoma mansoni regulator of G protein signaling 0.0812 0.1556 0.1545
Schistosoma mansoni protein kinase 0.0058 0.004 0.0027
Echinococcus multilocularis Rho GTPase activating protein 24 0.0074 0.0072 0.008
Loa Loa (eye worm) hypothetical protein 0.0371 0.0669 0.0664
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0064 0.0051 0.0054
Loa Loa (eye worm) protein kinase domain-containing protein 0.0058 0.004 0.0035
Brugia malayi PH domain containing protein 0.0074 0.0072 0.0067
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Schistosoma mansoni protein kinase 0.0058 0.004 0.0027
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.008 0.0084 0.0288
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0058 0.004 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.004 0.0258
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0074 0.0072 0.008
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Brugia malayi Guanylyl cyclase protein 23 0.0058 0.004 0.0035
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.004 0.0035
Brugia malayi PXA domain containing protein 0.0812 0.1556 0.1552
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Loa Loa (eye worm) hypothetical protein 0.0136 0.0197 0.0191
Loa Loa (eye worm) TK protein kinase 0.0058 0.004 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0072 0.0465
Entamoeba histolytica PH domain containing protein kinase, putative 0.0094 0.0113 0.0478
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0162 0.0249 0.1603
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0072 0.4445
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0249 0.1603
Entamoeba histolytica protein kinase, putative 0.0094 0.0113 0.0478
Echinococcus granulosus tyrosine protein kinase shark 0.0058 0.004 0.0042
Trypanosoma cruzi hypothetical protein 0.0074 0.0072 0.4445
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0249 0.1603
Brugia malayi integrin-linked kinase 0.0058 0.004 0.0035
Toxoplasma gondii aurora kinase 0.008 0.0084 0.6014
Brugia malayi SH2 domain containing protein 0.0058 0.004 0.0035
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Echinococcus granulosus receptor type guanylyl cyclase 0.0058 0.004 0.0042
Echinococcus multilocularis semaphorin 5B 0.0371 0.0669 0.0793
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0074 0.0072 0.0213
Trichomonas vaginalis AGC family protein kinase 0.008 0.0084 0.0539
Entamoeba histolytica hypothetical protein 0.0162 0.0249 0.138
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0074 0.0072 0.008
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0058 0.004 0.0035
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0074 0.0072 0.0465
Echinococcus multilocularis tyrosine protein kinase csk 0.0058 0.004 0.0042
Toxoplasma gondii phosphatidylinositol transfer protein 0.0074 0.0072 0.4445
Trypanosoma cruzi NIMA-related kinase, putative 0.0094 0.0113 1
Trypanosoma cruzi hypothetical protein 0.0074 0.0072 0.4445
Echinococcus granulosus semaphorin 1A 0.0371 0.0669 0.0793
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0064 0.0051 0.0054
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Echinococcus granulosus c src tyrosine kinase 0.0058 0.004 0.0042
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0058 0.004 0.0042
Echinococcus granulosus Pleckstrin y 0.0074 0.0072 0.008
Onchocerca volvulus 0.0874 0.1681 1
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0058 0.004 0.0035
Schistosoma mansoni hypothetical protein 0.0074 0.0072 0.0059
Loa Loa (eye worm) hypothetical protein 0.0074 0.0072 0.0067
Loa Loa (eye worm) PH domain-containing protein 0.0074 0.0072 0.0067
Trichomonas vaginalis centaurin alpha, putative 0.0074 0.0072 0.0465
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Brugia malayi ephrin receptor 1 precursor 0.0058 0.004 0.0035
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0074 0.0072 0.0213
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Loa Loa (eye worm) TK/Met protein kinase 0.0058 0.004 0.0035
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Echinococcus granulosus tyrosine protein kinase Srms 0.0058 0.004 0.0042
Echinococcus granulosus epidermal growth factor receptor 0.0058 0.004 0.0042
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0072 0.0465
Schistosoma mansoni oxysterol-binding protein 1 0.0074 0.0072 0.0059
Brugia malayi MAX-1A 0.0074 0.0072 0.0067
Toxoplasma gondii protein kinase domain-containing protein 0.0094 0.0113 1
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Brugia malayi TBC domain containing protein 0.0074 0.0072 0.0067
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Leishmania major hypothetical protein, conserved 0.0074 0.0072 0.4445
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0058 0.004 0.0035
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Echinococcus multilocularis activated cdc42 kinase 1 0.0058 0.004 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0072 0.0465
Echinococcus multilocularis tyrosine protein kinase csk 0.0058 0.004 0.0042
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Entamoeba histolytica PH domain containing protein kinase, putative 0.0094 0.0113 0.0478
Entamoeba histolytica protein kinase, putative 0.0094 0.0113 0.0478
Echinococcus multilocularis hypothetical protein 0.0371 0.0669 0.0793
Echinococcus granulosus ephrin type A receptor 4 A 0.0058 0.004 0.0042
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Brugia malayi Plexin repeat family protein 0.0874 0.1681 0.1677
Brugia malayi Dynamin 0.0074 0.0072 0.0067
Loa Loa (eye worm) uncoordinated protein 104 0.0074 0.0072 0.0067
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Schistosoma mansoni zinc finger protein 0.0074 0.0072 0.0059
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0074 0.0072 0.0059
Entamoeba histolytica hypothetical protein 0.0162 0.0249 0.138
Trichomonas vaginalis conserved hypothetical protein 0.0812 0.1556 1
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0094 0.0113 1
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0074 0.0072 0.0067
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.004 0.0035
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0058 0.004 0.0042
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0078 0.008 0.5555
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0074 0.0072 0.4445
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.004 0.0035
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.004 0.0035
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0136 0.0197 0.0184
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0094 0.0113 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0058 0.004 0.0042
Entamoeba histolytica protein kinase, putative 0.0094 0.0113 0.0478
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0074 0.0072 0.008
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0074 0.0072 0.0196
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0094 0.0113 1
Brugia malayi Cytohesin 3 0.0074 0.0072 0.0067
Entamoeba histolytica PH domain containing protein kinase, putative 0.0094 0.0113 0.0478
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0074 0.0072 0.008
Toxoplasma gondii AtPH1 family protein 0.0074 0.0072 0.4445
Schistosoma mansoni vav2 0.0074 0.0072 0.0059
Brugia malayi Furin-like cysteine rich region family protein 0.0058 0.004 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0072 0.0465
Echinococcus granulosus calcium dependent secretion activator 1 0.0074 0.0072 0.008
Trichomonas vaginalis AGC family protein kinase 0.008 0.0084 0.0539
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0072 0.0465
Echinococcus granulosus tyrosine protein kinase csk 0.0058 0.004 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0249 0.1603
Loa Loa (eye worm) TK/ROR protein kinase 0.0058 0.004 0.0035
Entamoeba histolytica hypothetical protein 0.0812 0.1556 1
Schistosoma mansoni hypothetical protein 0.0371 0.0669 0.0657
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0094 0.0113 0.0724
Brugia malayi DNA-binding protein LAG-1 0.0162 0.0249 0.0244
Schistosoma mansoni axis inhibition protein axin 0.0812 0.1556 0.1545
Brugia malayi Tyrosine-protein kinase abl-1 0.0058 0.004 0.0035
Echinococcus multilocularis tyrosine protein kinase Srms 0.0058 0.004 0.0042
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0058 0.004 0.0042
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Brugia malayi PH domain containing protein 0.0074 0.0072 0.0067
Leishmania major protein kinase, putative 0.008 0.0084 0.6014
Echinococcus multilocularis regulator of G protein signaling 3 0.0812 0.1556 0.1855
Entamoeba histolytica hypothetical protein 0.0812 0.1556 1
Entamoeba histolytica hypothetical protein 0.0162 0.0249 0.138
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0072 0.0465
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Entamoeba histolytica PH domain containing protein kinase, putative 0.0094 0.0113 0.0478
Loa Loa (eye worm) TK protein kinase 0.0058 0.004 0.0035
Brugia malayi PH domain containing protein 0.0074 0.0072 0.0067
Entamoeba histolytica hypothetical protein 0.0074 0.0072 0.0213
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0812 0.1556 0.1545
Trichomonas vaginalis protein tyrosine kinase, putative 0.0058 0.004 0.0258
Onchocerca volvulus 0.0074 0.0072 0.0196
Echinococcus multilocularis Pleckstrin y 0.0074 0.0072 0.008
Entamoeba histolytica hypothetical protein 0.0074 0.0072 0.0213
Schistosoma mansoni hypothetical protein 0.0503 0.0935 0.0923
Schistosoma mansoni centaurin alpha 0.0074 0.0072 0.0059
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0078 0.008 0.5555
Entamoeba histolytica hypothetical protein 0.0094 0.0113 0.0478
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0078 0.008 0.009
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0058 0.004 0.0258
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0074 0.0072 0.008
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0058 0.004 0.0042
Onchocerca volvulus 0.0371 0.0669 0.383
Trichomonas vaginalis centaurin/arf, putative 0.0074 0.0072 0.0465
Echinococcus granulosus tyrosine protein kinase Src64B 0.0058 0.004 0.0042
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Echinococcus multilocularis tyrosine protein kinase Abl 0.0058 0.004 0.0042
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0074 0.0072 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0072 0.0465
Onchocerca volvulus Putative zinc finger protein 0.0074 0.0072 0.0196
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0058 0.004 0.0035
Echinococcus multilocularis tyrosine kinase 0.0058 0.004 0.0042
Loa Loa (eye worm) hypothetical protein 0.0074 0.0072 0.0067
Echinococcus multilocularis raf serine:threonine protein kinase 0.0058 0.004 0.0042
Schistosoma mansoni nephrin 0.0141 0.0207 0.0194
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.004 0.0035
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0078 0.008 0.5555
Echinococcus granulosus pleckstrin y domain containing family A 0.0074 0.0072 0.008
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Echinococcus multilocularis Immunoglobulin 0.0136 0.0197 0.0229
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Loa Loa (eye worm) hypothetical protein 0.0058 0.004 0.0035
Brugia malayi Receptor family ligand binding region containing protein 0.0058 0.004 0.0035
Loa Loa (eye worm) PXA domain-containing protein 0.0812 0.1556 0.1552
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Schistosoma mansoni semaphorin 5-related 0.0371 0.0669 0.0657
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Brugia malayi Probable exocyst complex component Sec5 0.0162 0.0249 0.0244
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0058 0.004 0.0042
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0058 0.004 0.0027
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0058 0.004 0.0042
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0074 0.0072 0.0465
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Loa Loa (eye worm) cytohesin 3 0.0074 0.0072 0.0067
Brugia malayi Oxysterol-binding protein 0.0074 0.0072 0.0067
Entamoeba histolytica protein kinase, putative 0.0094 0.0113 0.0478
Loa Loa (eye worm) oxysterol binding protein 0.0074 0.0072 0.0067
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Loa Loa (eye worm) TK/RYK protein kinase 0.0058 0.004 0.0035
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0162 0.0249 0.1603
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0084 0.0288
Trichomonas vaginalis hypothetical protein 0.0074 0.0072 0.0465
Onchocerca volvulus 0.0074 0.0072 0.0196
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Loa Loa (eye worm) hypothetical protein 0.0058 0.004 0.0035
Loa Loa (eye worm) hypothetical protein 0.0812 0.1556 0.1552
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0072 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.004 0.0258
Schistosoma mansoni hypothetical protein 0.0074 0.0072 0.0059
Loa Loa (eye worm) hypothetical protein 0.0136 0.0197 0.0191
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Loa Loa (eye worm) hypothetical protein 0.0136 0.0197 0.0191
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0074 0.0072 0.0465
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0058 0.004 0.0035
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0072 0.0465
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0074 0.0072 0.008
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0094 0.0113 1
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Echinococcus granulosus oxysterol binding protein 9 0.0074 0.0072 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.004 0.0027
Loa Loa (eye worm) TK/EPH protein kinase 0.0058 0.004 0.0035
Entamoeba histolytica tyrosin kinase, putative 0.0221 0.0367 0.2156
Trypanosoma cruzi Protein kinase B 0.0094 0.0113 1
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Schistosoma mansoni dynamin 0.0074 0.0072 0.0059
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0094 0.0113 1
Schistosoma mansoni hypothetical protein 0.0162 0.0249 0.0237
Loa Loa (eye worm) TK/INSR protein kinase 0.0058 0.004 0.0035
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.004 0.0035
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0058 0.004 0.0035
Entamoeba histolytica PH domain containing protein kinase, putative 0.0094 0.0113 0.0478
Trichomonas vaginalis CAMK family protein kinase 0.0058 0.004 0.0258
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0058 0.004 0.0042
Loa Loa (eye worm) plexin A 0.1036 0.2008 0.2004
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Echinococcus multilocularis expressed protein 0.0812 0.1556 0.1855
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0072 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.004 0.0258
Echinococcus granulosus tyrosine kinase 0.0058 0.004 0.0042
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0058 0.004 0.0042
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Entamoeba histolytica hypothetical protein 0.0074 0.0072 0.0213
Loa Loa (eye worm) TK protein kinase 0.0058 0.004 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Loa Loa (eye worm) hypothetical protein 0.0141 0.0207 0.0202
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Echinococcus granulosus aurora kinase A 0.008 0.0084 0.0094
Echinococcus multilocularis myotubularin protein 13 0.0074 0.0072 0.008
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Trichomonas vaginalis kinesin light chain, putative 0.0074 0.0072 0.0465
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0074 0.0072 0.0213
Echinococcus granulosus epidermal growth factor receptor 0.0058 0.004 0.0042
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0058 0.004 0.0035
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0074 0.0072 0.0213
Schistosoma mansoni serine/threonine-protein kinase 0.0094 0.0113 0.01
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0074 0.0072 0.008
Loa Loa (eye worm) hypothetical protein 0.0074 0.0072 0.0067
Brugia malayi Raf kinase 0.0058 0.004 0.0035
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0074 0.0072 0.008
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0074 0.0072 0.0213
Schistosoma mansoni tyrosine kinase 0.0072 0.0067 0.0054
Echinococcus multilocularis pleckstrin y domain containing family A 0.0074 0.0072 0.008
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Echinococcus granulosus myotubularin protein 13 0.0074 0.0072 0.008
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.004 0.0035
Loa Loa (eye worm) TK protein kinase 0.0058 0.004 0.0035
Echinococcus granulosus beta-adrenergic receptor kinase 0.3837 0.7647 0.914
Echinococcus granulosus protein kinase 0.0058 0.004 0.0042
Loa Loa (eye worm) hypothetical protein 0.0074 0.0072 0.0067
Loa Loa (eye worm) hypothetical protein 0.0162 0.0249 0.0244
Echinococcus multilocularis oxysterol binding protein 9 0.0074 0.0072 0.008
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0074 0.0072 0.008
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Trypanosoma brucei aurora B kinase 0.008 0.0084 0.6014
Brugia malayi Fibronectin type III domain containing protein 0.0141 0.0207 0.0202
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Echinococcus multilocularis epidermal growth factor receptor 0.0058 0.004 0.0042
Trichomonas vaginalis TK family protein kinase 0.0058 0.004 0.0258
Loa Loa (eye worm) TK protein kinase 0.0058 0.004 0.0035
Brugia malayi Variant SH3 domain containing protein 0.0074 0.0072 0.0067
Schistosoma mansoni tyrosine kinase 0.0058 0.004 0.0027
Echinococcus multilocularis natriuretic peptide receptor 1 0.0058 0.004 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0072 0.0465
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0074 0.0072 0.0059
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0074 0.0072 0.0213
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0812 0.1556 0.1855
Echinococcus granulosus twitchin 0.0156 0.0237 0.0277
Trypanosoma cruzi PH domain containing protein, putative 0.0074 0.0072 0.4445
Loa Loa (eye worm) hypothetical protein 0.0141 0.0207 0.0202
Trichomonas vaginalis AGC family protein kinase 0.008 0.0084 0.0539
Echinococcus granulosus retinal guanylyl cyclase 2 0.0058 0.004 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0812 0.1556 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.0223 0.0218
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Loa Loa (eye worm) TK protein kinase 0.0058 0.004 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Toxoplasma gondii hypothetical protein 0.0074 0.0072 0.4445
Trichomonas vaginalis AGC family protein kinase 0.0094 0.0113 0.0724
Loa Loa (eye worm) hypothetical protein 0.0074 0.0072 0.0067
Schistosoma mansoni regulator of G protein signaling 0.0812 0.1556 0.1545
Brugia malayi Protein kinase domain containing protein 0.0058 0.004 0.0035
Echinococcus multilocularis tyrosine protein kinase shark 0.0058 0.004 0.0042
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0058 0.004 0.0027
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.008 0.0084 0.0288
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.008 0.0084 0.0094
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Entamoeba histolytica protein kinase, putative 0.0094 0.0113 0.0478
Entamoeba histolytica PH domain containing protein 0.0074 0.0072 0.0213
Brugia malayi hypothetical protein 0.0141 0.0207 0.0202
Echinococcus granulosus tyrosine protein kinase Fyn 0.0058 0.004 0.0042
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0058 0.004 0.0042
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0058 0.004 0.0042
Loa Loa (eye worm) TK/CSK protein kinase 0.0058 0.004 0.0035
Schistosoma mansoni z-protein (S1r protein) 0.0812 0.1556 0.1545
Echinococcus granulosus dynamin 1 0.0074 0.0072 0.008
Brugia malayi regulator of G-protein signaling egl-10 0.0812 0.1556 0.1552
Loa Loa (eye worm) TK protein kinase 0.0058 0.004 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Loa Loa (eye worm) hypothetical protein 0.0162 0.0249 0.0244
Schistosoma mansoni myotubularin-related protein 0.0074 0.0072 0.0059
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.004 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0058 0.004 0.0258
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0094 0.0113 1
Loa Loa (eye worm) AUR protein kinase 0.008 0.0084 0.0078
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0058 0.004 0.0027
Loa Loa (eye worm) hypothetical protein 0.0812 0.1556 0.1552
Echinococcus granulosus retinal guanylyl cyclase 2 0.0058 0.004 0.0042
Echinococcus granulosus raf serine:threonine protein kinase 0.0058 0.004 0.0042

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.03 uM Cytotoxicity against human U937 GTB cells after 72 hrs by fluorometric microculture cytotoxicity assay ChEMBL. 16562840
IC50 (functional) = 8.01 uM Cytotoxicity against multidrug-resistant human ACHN cells after 72 hrs by fluorometric microculture cytotoxicity assay ChEMBL. 16562840
Inhibition (functional) = 96 % Antibacterial activity against Mycobacterium tuberculosis H37Rv at 6.25 mg/ml ChEMBL. 16562840
MIC (functional) > 6.25 ug ml-1 Antibacterial activity against Mycobacterium tuberculosis by standard broth microdilution technique ChEMBL. 16562840
MIC (functional) = 8 ug ml-1 Antibacterial activity against Escherichia coli ATCC 25922 by standard broth microdilution technique ChEMBL. 16562840

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 16562840

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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