TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 388.249 | Formula: C15H19Cl2N5O3
H donors: 3 H acceptors: 5 LogP: 1.71 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: ClC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1
InChi: 1S/C15H19Cl2N5O3/c16-5-8-10(23)11(24)14(25-8)22-6-18-9-12(19-7-3-1-2-4-7)20-15(17)21-13(9)22/h6-8,10-11,14,23-24H,1-5H2,(H,19,20,21)/t8-,10-,11-,14-/m1/s1
InChiKey: GWUOJELSUSGGDU-IDTAVKCVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	adenosine A2b receptor	Starlite/ChEMBL	References
Homo sapiens	adenosine A2a receptor	Starlite/ChEMBL	References
Homo sapiens	adenosine A3 receptor	Starlite/ChEMBL	References
Homo sapiens	adenosine A1 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	hypothetical protein	adenosine A1 receptor	326 aa	305 aa	21.0 %
Brugia malayi	follicle stimulating hormone receptor	adenosine A2a receptor	412 aa	336 aa	22.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	aurora B kinase, putative	0.0079	0.0089	0.7147
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Echinococcus granulosus	tyrosine protein kinase shark	0.0057	0.0042	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0166	0.028	0.1807
Trypanosoma cruzi	hypothetical protein	0.0069	0.0067	0.3838
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0087	0.0107	1
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Echinococcus granulosus	tyrosine protein kinase Blk	0.0057	0.0042	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0166	0.028	0.1807
Entamoeba histolytica	protein kinase, putative	0.0079	0.0089	0.031
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0069	0.0067	0.3838
Loa Loa (eye worm)	TK/ALK protein kinase	0.03	0.0572	0.0567
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0067	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0042	0.0269
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0042	0.0036
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0057	0.0042	0.0036
Entamoeba histolytica	protein kinase, putative	0.0087	0.0107	0.0434
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0042	0.0036
Echinococcus multilocularis	neuroglian	0.0111	0.016	0.0184
Leishmania major	serine/threonine-protein kinase a, putative	0.0087	0.0107	1
Brugia malayi	PXA domain containing protein	0.0749	0.1552	0.1547
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0062	0.0053	0.0056
Trichomonas vaginalis	conserved hypothetical protein	0.0166	0.028	0.1807
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0069	0.0067	0.0431
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Entamoeba histolytica	hypothetical protein	0.0166	0.028	0.1581
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0166	0.028	0.1807
Trichomonas vaginalis	centaurin/arf, putative	0.0069	0.0067	0.0431
Trypanosoma cruzi	PH domain containing protein, putative	0.0069	0.0067	0.3838
Echinococcus multilocularis	tyrosine protein kinase csk	0.0057	0.0042	0.0043
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Loa Loa (eye worm)	hypothetical protein	0.038	0.0747	0.0741
Echinococcus multilocularis	cytohesin 1	0.0069	0.0067	0.0073
Schistosoma mansoni	protein kinase	0.0057	0.0042	0.0028
Echinococcus multilocularis	regulator of G protein signaling 3	0.0749	0.1552	0.1849
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0057	0.0042	0.0028
Echinococcus granulosus	aurora kinase A	0.0079	0.0089	0.0099
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0057	0.0042	0.0043
Schistosoma mansoni	growth factor receptor-bound protein	0.0069	0.0067	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0067	0.0431
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Echinococcus multilocularis	tyrosine kinase	0.0057	0.0042	0.0043
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Entamoeba histolytica	tyrosin kinase, putative	0.0224	0.0405	0.2407
Trypanosoma brucei	protein kinase, putative	0.0076	0.0082	0.6162
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Loa Loa (eye worm)	TK/INSR protein kinase	0.0057	0.0042	0.0036
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0057	0.0042	0.0043
Echinococcus granulosus	GRB2 associated binding protein 3	0.0069	0.0067	0.0073
Brugia malayi	protein-tyrosine kinase	0.0057	0.0042	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0067	0.0061
Schistosoma mansoni	hypothetical protein	0.0069	0.0067	0.0053
Echinococcus granulosus	ephrin type A receptor 4 A	0.0057	0.0042	0.0043
Echinococcus multilocularis	semaphorin 5B	0.038	0.0747	0.0886
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0087	0.0107	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0057	0.0042	0.0043
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0069	0.0067	0.0073
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0087	0.0107	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0087	0.0107	0.0434
Echinococcus granulosus	oxysterol binding protein 3	0.0069	0.0067	0.0073
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Schistosoma mansoni	plexin	0.0896	0.1873	0.1862
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Brugia malayi	PH domain containing protein	0.0069	0.0067	0.0061
Echinococcus multilocularis	pdz domain containing protein	0.0069	0.0067	0.0073
Echinococcus granulosus	regulator of G protein signaling 7	0.0749	0.1552	0.1849
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0069	0.0067	0.0053
Echinococcus granulosus	twitchin	0.013	0.02	0.0232
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0087	0.0107	1
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Schistosoma mansoni	vav2	0.0069	0.0067	0.0053
Schistosoma mansoni	centaurin alpha	0.0069	0.0067	0.0053
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0087	0.0107	1
Brugia malayi	probable spectrin beta chain	0.0069	0.0067	0.0061
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0057	0.0042	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0067	0.0061
Echinococcus granulosus	tyrosine protein kinase Srms	0.0057	0.0042	0.0043
Echinococcus granulosus	epidermal growth factor receptor	0.0057	0.0042	0.0043
Echinococcus granulosus	beta 1 syntrophin	0.0069	0.0067	0.0073
Echinococcus granulosus	serine/threonine protein kinase	0.0087	0.0107	0.0121
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Loa Loa (eye worm)	SRC-1	0.0057	0.0042	0.0036
Echinococcus multilocularis	beta 1 syntrophin	0.0069	0.0067	0.0073
Onchocerca volvulus		0.0069	0.0067	0.0137
Brugia malayi	Cytohesin 3	0.0069	0.0067	0.0061
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0057	0.0042	0.0036
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0069	0.0067	0.3838
Onchocerca volvulus		0.0896	0.1873	1
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0067	0.0431
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0069	0.0067	0.0167
Echinococcus multilocularis	tyrosine protein kinase csk	0.0057	0.0042	0.0043
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0042	0.0036
Trichomonas vaginalis	kinesin light chain, putative	0.0069	0.0067	0.0431
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Echinococcus multilocularis	protein kinase	0.0057	0.0042	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0067	0.0431
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0042	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Loa Loa (eye worm)	hypothetical protein	0.038	0.0747	0.0741
Trypanosoma brucei	protein kinase, putative	0.0087	0.0107	1
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0069	0.0067	0.0073
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0069	0.0067	0.3838
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0057	0.0042	0.0043
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0057	0.0042	0.0043
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0057	0.0042	0.0043
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0057	0.0042	0.0043
Echinococcus granulosus	kinase suppressor of Ras 1	0.0057	0.0042	0.0043
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0076	0.0082	0.0091
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Echinococcus granulosus	DCC interacting protein 13 beta	0.0069	0.0067	0.0073
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0067	0.0431
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0057	0.0042	0.0043
Loa Loa (eye worm)	hypothetical protein	0.038	0.0747	0.0741
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0087	0.0107	1
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Echinococcus granulosus	tyrosine protein kinase HCK	0.0057	0.0042	0.0043
Schistosoma mansoni	ephrin receptor	0.0062	0.0053	0.0039
Entamoeba histolytica	PH domain containing protein	0.0069	0.0067	0.0167
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0057	0.0042	0.0036
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0057	0.0042	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0067	0.0061
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.387	0.8365	0.8364
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0057	0.0042	0.0043
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0057	0.0042	0.0043
Trichomonas vaginalis	STE family protein kinase	0.0057	0.0042	0.0269
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0057	0.0042	0.0043
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0087	0.0107	0.0691
Schistosoma mansoni	serine/threonine-protein kinase	0.0087	0.0107	0.0093
Brugia malayi	regulator of G-protein signaling rgs-7	0.0749	0.1552	0.1547
Trypanosoma cruzi	PH domain containing protein, putative	0.0069	0.0067	0.3838
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0076	0.0082	0.6162
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0057	0.0042	0.0036
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0042	0.0036
Echinococcus granulosus	oxysterol binding protein 9	0.0069	0.0067	0.0073
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0057	0.0042	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0749	0.1552	0.1547
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0057	0.0042	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Echinococcus multilocularis	Immunoglobulin	0.0111	0.016	0.0184
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0069	0.0067	0.0167
Schistosoma mansoni	hypothetical protein	0.0069	0.0067	0.0053
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0057	0.0042	0.0043
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0166	0.028	0.1807
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Onchocerca volvulus		0.038	0.0747	0.3849
Trichomonas vaginalis	conserved hypothetical protein	0.0166	0.028	0.1807
Echinococcus multilocularis	protein kinase	0.0057	0.0042	0.0043
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0069	0.0067	0.3838
Leishmania major	hypothetical protein, conserved	0.0069	0.0067	0.3838
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0057	0.0042	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0749	0.1552	0.1547
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0057	0.0042	0.0043
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0749	0.1552	0.1849
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0069	0.0067	0.0073
Echinococcus granulosus	activated cdc42 kinase 1	0.0057	0.0042	0.0043
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Echinococcus multilocularis	tyrosine kinase	0.0057	0.0042	0.0043
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Schistosoma mansoni	fibrocystin l	0.0166	0.028	0.0267
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Echinococcus granulosus	Regulator of G protein signaling 20	0.0749	0.1552	0.1849
Brugia malayi	Protein kinase domain containing protein	0.0087	0.0107	0.0101
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.387	0.8365	0.8364
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0749	0.1552	0.1849
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0079	0.0089	0.057
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0067	0.0431
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0087	0.0107	1
Echinococcus granulosus	axis inhibition protein axin	0.0749	0.1552	0.1849
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0079	0.0089	0.031
Brugia malayi	PXA domain containing protein	0.0749	0.1552	0.1547
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0079	0.0089	0.7147
Echinococcus multilocularis	hypothetical protein	0.038	0.0747	0.0886
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0057	0.0042	0.0028
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0057	0.0042	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0067	0.0061
Trichomonas vaginalis	protein transport protein sec7, putative	0.0069	0.0067	0.0431
Echinococcus granulosus	tyrosine kinase	0.0057	0.0042	0.0043
Entamoeba histolytica	hypothetical protein	0.0087	0.0107	0.0434
Onchocerca volvulus	Putative zinc finger protein	0.0069	0.0067	0.0137
Brugia malayi	Furin-like cysteine rich region family protein	0.0057	0.0042	0.0036
Schistosoma mansoni	goodpasture antigen-binding protein	0.0069	0.0067	0.0053
Schistosoma mansoni	goodpasture antigen-binding protein	0.0069	0.0067	0.0053
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0042	0.0036
Schistosoma mansoni	syntrophin	0.0069	0.0067	0.0053
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0042	0.0036
Toxoplasma gondii	hypothetical protein	0.0069	0.0067	0.3838
Schistosoma mansoni	dynamin	0.0069	0.0067	0.0053
Loa Loa (eye worm)	hypothetical protein	0.038	0.0747	0.0741
Brugia malayi	PH domain containing protein	0.0069	0.0067	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0067	0.0061
Schistosoma mansoni	hypothetical protein	0.0069	0.0067	0.0053
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0069	0.0067	0.0073
Brugia malayi	TBC domain containing protein	0.0069	0.0067	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Brugia malayi	hypothetical protein	0.038	0.0747	0.0741
Entamoeba histolytica	p21-activated kinase	0.0087	0.0107	0.0434
Trichomonas vaginalis	hypothetical protein	0.0069	0.0067	0.0431
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0057	0.0042	0.0028
Brugia malayi	Oxysterol binding protein	0.0069	0.0067	0.0061
Brugia malayi	hypothetical protein	0.0069	0.0067	0.0061
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0069	0.0067	0.0073
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.354	0.7646	0.7644
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Echinococcus granulosus	axis inhibition protein axin	0.0749	0.1552	0.1849
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0042	0.0269
Echinococcus granulosus	Pleckstrin y	0.0069	0.0067	0.0073
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0171	0.0165
Trypanosoma brucei	PH domain containing protein, putative	0.0069	0.0067	0.3838
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0057	0.0042	0.0269
Echinococcus granulosus	dynamin 1	0.0069	0.0067	0.0073
Trichomonas vaginalis	TK family protein kinase	0.0057	0.0042	0.0269
Echinococcus multilocularis	aurora kinase A	0.0079	0.0089	0.0099
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Schistosoma mansoni	vesicular amine transporter	0.0114	0.0165	0.0152
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0057	0.0042	0.0043
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Entamoeba histolytica	hypothetical protein	0.0087	0.0107	0.0434
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0069	0.0067	0.0167
Loa Loa (eye worm)	TK/Met protein kinase	0.0057	0.0042	0.0036
Echinococcus multilocularis	Pleckstrin y	0.0069	0.0067	0.0073
Trichomonas vaginalis	centaurin/arf, putative	0.0069	0.0067	0.0431
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Echinococcus granulosus	epidermal growth factor receptor	0.0057	0.0042	0.0043
Trypanosoma cruzi	hypothetical protein	0.0069	0.0067	0.3838
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0069	0.0067	0.0073
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0062	0.0053	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0067	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0069	0.0067	0.0073
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0069	0.0067	0.0073
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0166	0.028	0.1807
Schistosoma mansoni	serine/threonine protein kinase	0.354	0.7646	0.7642
Echinococcus granulosus	protein kinase	0.0057	0.0042	0.0043
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0042	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0042	0.0036
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0069	0.0067	0.0061
Echinococcus granulosus	tyrosine kinase	0.0057	0.0042	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0042	0.0269
Entamoeba histolytica	hypothetical protein	0.0749	0.1552	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0067	0.0061
Schistosoma mansoni	protein tyrosine kinase	0.0057	0.0042	0.0028
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0069	0.0067	0.3838
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0057	0.0042	0.0043
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0069	0.0067	0.0061
Trypanosoma brucei	aurora B kinase	0.0079	0.0089	0.7147
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Echinococcus granulosus	neuroglian	0.0111	0.016	0.0184
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0069	0.0067	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0067	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Echinococcus multilocularis	rac serine:threonine kinase	0.0087	0.0107	0.0121
Echinococcus multilocularis	integrin linked protein kinase	0.0057	0.0042	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0214	0.0384	0.0378
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0042	0.0036
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0069	0.0067	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0042	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0042	0.0036
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0057	0.0042	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0042	0.0036
Entamoeba histolytica	hypothetical protein	0.0166	0.028	0.1581
Entamoeba histolytica	protein kinase, putative	0.0087	0.0107	0.0434
Brugia malayi	Plekhf2 protein	0.0069	0.0067	0.0061
Brugia malayi	Tyrosine-protein kinase abl-1	0.0057	0.0042	0.0036
Trichomonas vaginalis	CAMK family protein kinase	0.0057	0.0042	0.0269
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0087	0.0107	1
Brugia malayi	ephrin receptor 1 precursor	0.0057	0.0042	0.0036
Brugia malayi	Plexin repeat family protein	0.0896	0.1873	0.1868
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.0042	0.0028
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Schistosoma mansoni	regulator of G protein signaling	0.0749	0.1552	0.154
Brugia malayi	PH domain containing protein	0.0069	0.0067	0.0061
Brugia malayi	SH2 domain containing protein	0.0057	0.0042	0.0036
Brugia malayi	PH domain containing protein	0.0069	0.0067	0.0061
Echinococcus granulosus	exocyst complex component 2	0.0166	0.028	0.0328
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Trypanosoma cruzi	NIMA-related kinase, putative	0.0087	0.0107	1
Loa Loa (eye worm)	AUR protein kinase	0.0079	0.0089	0.0083
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Echinococcus granulosus	raf serine:threonine protein kinase	0.0057	0.0042	0.0043
Echinococcus granulosus	receptor type guanylyl cyclase	0.0057	0.0042	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0749	0.1552	1
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0087	0.0107	1
Loa Loa (eye worm)	hypothetical protein	0.0111	0.016	0.0154
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0057	0.0042	0.0043
Echinococcus granulosus	pdz domain containing protein	0.0069	0.0067	0.0073
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0057	0.0042	0.0043
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0057	0.0042	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0042	0.0036
Schistosoma mansoni	regulator of G protein signaling	0.0749	0.1552	0.154
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0042	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0171	0.0165
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0042	0.0036
Toxoplasma gondii	hypothetical protein	0.0069	0.0067	0.3838
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0079	0.0089	0.7147
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Echinococcus multilocularis	tyrosine protein kinase	0.0057	0.0042	0.0043
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0057	0.0042	0.0028
Loa Loa (eye worm)	PXA domain-containing protein	0.0749	0.1552	0.1547
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0057	0.0042	0.0043
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0069	0.0067	0.0137
Entamoeba histolytica	protein kinase, putative	0.0087	0.0107	0.0434
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0079	0.0089	0.031
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0067	0.0431
Schistosoma mansoni	dynamin	0.0069	0.0067	0.0053
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Echinococcus multilocularis	tyrosine protein kinase csk	0.0057	0.0042	0.0043
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0069	0.0067	0.0073
Echinococcus multilocularis	roundabout 2	0.0116	0.0171	0.0197
Brugia malayi	Variant SH3 domain containing protein	0.0069	0.0067	0.0061
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0069	0.0067	0.0167
Echinococcus multilocularis	regulator of G protein signaling 7	0.0749	0.1552	0.1849
Schistosoma mansoni	regulator of G protein signaling	0.0749	0.1552	0.154
Toxoplasma gondii	aurora kinase	0.0079	0.0089	0.7147
Brugia malayi	hypothetical protein	0.0116	0.0171	0.0165
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0057	0.0042	0.0043
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0057	0.0042	0.0036
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0087	0.0107	1
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Entamoeba histolytica	hypothetical protein	0.0749	0.1552	1
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0069	0.0067	0.0167
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0069	0.0067	0.3838
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0067	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0067	0.0431
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0057	0.0042	0.0269
Entamoeba histolytica	protein kinase, putative	0.0087	0.0107	0.0434
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0076	0.0082	0.6162
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Schistosoma mansoni	protein kinase	0.0076	0.0082	0.0068
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0069	0.0067	0.0167
Brugia malayi	Syntrophin-1	0.0069	0.0067	0.0061
Loa Loa (eye worm)	hypothetical protein	0.038	0.0747	0.0741
Schistosoma mansoni	hypothetical protein	0.0166	0.028	0.0267
Echinococcus granulosus	tyrosine protein kinase csk	0.0057	0.0042	0.0043
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0087	0.0107	1
Loa Loa (eye worm)	hypothetical protein	0.0166	0.028	0.0275
Schistosoma mansoni	hypothetical protein	0.038	0.0747	0.0733
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Brugia malayi	hypothetical protein	0.0749	0.1552	0.1547
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0057	0.0042	0.0043
Echinococcus granulosus	expressed protein	0.0749	0.1552	0.1849
Echinococcus multilocularis	c src tyrosine kinase	0.0057	0.0042	0.0043
Trichomonas vaginalis	centaurin gamma, putative	0.0069	0.0067	0.0431
Brugia malayi	Probable exocyst complex component Sec5	0.0166	0.028	0.0275
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0749	0.1552	0.1547
Loa Loa (eye worm)	hypothetical protein	0.0749	0.1552	0.1547
Schistosoma mansoni	zinc finger protein	0.0069	0.0067	0.0053
Loa Loa (eye worm)	AUR protein kinase	0.0079	0.0089	0.0083
Echinococcus multilocularis	FL cytokine receptor	0.0057	0.0042	0.0043
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0057	0.0042	0.0043
Brugia malayi	PH domain containing protein	0.0069	0.0067	0.0061
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Echinococcus granulosus	integrin linked protein kinase	0.0057	0.0042	0.0043
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0111	0.016	0.0146
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Entamoeba histolytica	hypothetical protein, conserved	0.0069	0.0067	0.0167
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0069	0.0067	0.0073
Loa Loa (eye worm)	PH domain-containing protein	0.0069	0.0067	0.0061
Brugia malayi	MAX-1A	0.0069	0.0067	0.0061
Brugia malayi	PH domain containing protein	0.0069	0.0067	0.0061
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0057	0.0042	0.0036
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0069	0.0067	0.0061
Toxoplasma gondii	protein kinase domain-containing protein	0.0087	0.0107	1
Toxoplasma gondii	AtPH1 family protein	0.0069	0.0067	0.3838
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0067	0.0061
Giardia lamblia	Aurora kinase	0.0079	0.0089	1
Brugia malayi	Raf kinase	0.0057	0.0042	0.0036
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0042	0.0036
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0057	0.0042	0.0036
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0069	0.0067	0.0073
Schistosoma mansoni	protein kinase	0.0076	0.0082	0.0068
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0042	0.0036
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.0042	0.0028
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0069	0.0067	0.0073
Echinococcus granulosus	tyrosine protein kinase csk	0.0057	0.0042	0.0043
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0042	0.0036
Echinococcus multilocularis	dynamin 1	0.0069	0.0067	0.0073
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Leishmania major	folate/biopterin transporter, putative	0.0087	0.0107	1
Loa Loa (eye worm)	oxysterol binding protein	0.0069	0.0067	0.0061
Loa Loa (eye worm)	uncoordinated protein 104	0.0069	0.0067	0.0061
Entamoeba histolytica	protein kinase, putative	0.0087	0.0107	0.0434
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Loa Loa (eye worm)	TK/EPH protein kinase	0.0057	0.0042	0.0036
Schistosoma mansoni	serine/threonine-protein kinase	0.0087	0.0107	0.0093
Echinococcus multilocularis	oxysterol binding protein 3	0.0069	0.0067	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0166	0.028	0.0275
Brugia malayi	serine/threonine-protein kinase 6	0.0079	0.0089	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0067	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0069	0.0067	0.0073
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0069	0.0067	0.0073
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Echinococcus multilocularis	axis inhibition protein axin	0.0749	0.1552	0.1849
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0111	0.016	0.0146
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0111	0.016	0.0184
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0042	0.0269
Echinococcus granulosus	calcium dependent secretion activator 1	0.0069	0.0067	0.0073
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0057	0.0042	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0111	0.016	0.0154
Echinococcus granulosus	pleckstrin y domain containing family A	0.0069	0.0067	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0111	0.016	0.0154
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0057	0.0042	0.0036
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0076	0.0082	0.0091
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0057	0.0042	0.0036
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0057	0.0042	0.0043
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0749	0.1552	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0042	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0042	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Schistosoma mansoni	hypothetical protein	0.038	0.0747	0.0733
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Brugia malayi	Oxysterol-binding protein	0.0069	0.0067	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0069	0.0067	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0067	0.0061
Brugia malayi	Receptor family ligand binding region containing protein	0.0057	0.0042	0.0036
Echinococcus multilocularis	exocyst complex component 2	0.0166	0.028	0.0328
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0057	0.0042	0.0028
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0057	0.0042	0.0043
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0057	0.0042	0.0043
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Echinococcus granulosus	myotubularin protein 13	0.0069	0.0067	0.0073
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0057	0.0042	0.0269
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0057	0.0042	0.0043
Echinococcus granulosus	semaphorin 5B	0.038	0.0747	0.0886
Echinococcus multilocularis	tyrosine protein kinase shark	0.0057	0.0042	0.0043
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0057	0.0042	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0067	0.0431
Echinococcus multilocularis	epidermal growth factor receptor	0.0057	0.0042	0.0043
Onchocerca volvulus	outspread protein homolog	0.0069	0.0067	0.0137
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0067	0.0431
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0069	0.0067	0.0431
Entamoeba histolytica	hypothetical protein	0.0069	0.0067	0.0167
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Schistosoma mansoni	hypothetical protein	0.0057	0.0042	0.0028
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0087	0.0107	1
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0067	0.0431
Schistosoma mansoni	nephrin	0.0116	0.0171	0.0157
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0069	0.0067	0.0431
Trichomonas vaginalis	centaurin beta, putative	0.0069	0.0067	0.0431
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0057	0.0042	0.0043
Entamoeba histolytica	protein kinase domain containing protein	0.0079	0.0089	0.031
Entamoeba histolytica	cell surface protease gp63, putative	0.0166	0.028	0.1581
Trichomonas vaginalis	AGC family protein kinase	0.0079	0.0089	0.057
Echinococcus granulosus	tyrosine protein kinase csk	0.0057	0.0042	0.0043
Schistosoma mansoni	tyrosine protein kinase	0.0057	0.0042	0.0028
Echinococcus multilocularis	expressed protein	0.0749	0.1552	0.1849
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0069	0.0067	0.0053
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0042	0.0036
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0042	0.0036
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Onchocerca volvulus	Protein melted homolog	0.0069	0.0067	0.0137
Schistosoma mansoni	axis inhibition protein axin	0.0749	0.1552	0.154
Echinococcus multilocularis	epidermal growth factor receptor	0.0057	0.0042	0.0043
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0057	0.0042	0.0036
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.4618	1	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0042	0.0036
Trichomonas vaginalis	protein transport protein sec7, putative	0.0069	0.0067	0.0431
Echinococcus granulosus	insulin receptor	0.0057	0.0042	0.0043
Loa Loa (eye worm)	Plekhf2 protein	0.0069	0.0067	0.0061
Brugia malayi	SH2 domain containing protein	0.0057	0.0042	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Schistosoma mansoni	regulator of G protein signaling	0.0749	0.1552	0.154
Brugia malayi	Dynamin	0.0069	0.0067	0.0061
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0057	0.0042	0.0043
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0057	0.0042	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0067	0.0431
Echinococcus multilocularis	regulator of G protein signaling 7	0.0749	0.1552	0.1849
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Echinococcus multilocularis	insulin receptor	0.0057	0.0042	0.0043
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0069	0.0067	0.3838
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0057	0.0042	0.0043
Leishmania major	protein kinase, putative	0.0087	0.0107	1
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Schistosoma mansoni	serine/threonine protein kinase	0.354	0.7646	0.7642
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0042	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Entamoeba histolytica	protein kinase, putative	0.0079	0.0089	0.031
Entamoeba histolytica	protein kinase, putative	0.0087	0.0107	0.0434
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0057	0.0042	0.0269
Brugia malayi	serine/threonine kinase 12	0.0079	0.0089	0.0083
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Leishmania major	hypothetical protein, conserved	0.0069	0.0067	0.3838
Brugia malayi	hypothetical protein	0.0057	0.0042	0.0036
Entamoeba histolytica	hypothetical protein	0.0166	0.028	0.1581
Brugia malayi	Dynamin	0.0069	0.0067	0.0061
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0057	0.0042	0.0269
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Leishmania major	protein kinase, putative	0.0087	0.0107	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0042	0.0036
Schistosoma mansoni	cell adhesion molecule	0.0116	0.0171	0.0157
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0069	0.0067	0.0167
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0087	0.0107	0.0434
Brugia malayi	Tyrosine-protein kinase PR2	0.0057	0.0042	0.0036
Echinococcus granulosus	natriuretic peptide receptor 1	0.0057	0.0042	0.0043
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0087	0.0107	0.0434
Echinococcus granulosus	c src tyrosine kinase	0.0057	0.0042	0.0043
Echinococcus granulosus	regulator of G protein signaling 3	0.0749	0.1552	0.1849
Trichomonas vaginalis	conserved hypothetical protein	0.0749	0.1552	1
Trichomonas vaginalis	conserved hypothetical protein	0.0749	0.1552	1
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Echinococcus granulosus	oxysterol binding protein 1	0.0069	0.0067	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0166	0.028	0.0275
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0087	0.0107	1
Schistosoma mansoni	protein kinase	0.0057	0.0042	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0111	0.016	0.0154
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0069	0.0067	0.0053
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0069	0.0067	0.0137
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.0042	0.0028
Trichomonas vaginalis	centaurin alpha, putative	0.0069	0.0067	0.0431
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0166	0.028	0.1807
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0749	0.1552	0.154
Entamoeba histolytica	protein kinase domain containing protein	0.0224	0.0405	0.2407
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0069	0.0067	0.0073
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0057	0.0042	0.0036
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0042	0.0036
Entamoeba histolytica	hypothetical protein	0.0166	0.028	0.1581
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0076	0.0082	0.6162
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Schistosoma mansoni	rho gtpase activating protein	0.0069	0.0067	0.0053
Echinococcus multilocularis	activin receptor type	0.0076	0.0082	0.0091
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0087	0.0107	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0087	0.0107	0.0434
Brugia malayi	hypothetical protein	0.0749	0.1552	0.1547
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0749	0.1552	0.1547
Echinococcus granulosus	Immunoglobulin	0.0111	0.016	0.0184
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Echinococcus granulosus	Pleckstrin y	0.0069	0.0067	0.0073
Loa Loa (eye worm)	hypothetical protein	0.038	0.0747	0.0741
Loa Loa (eye worm)	plexin A	0.1062	0.2236	0.2232
Schistosoma mansoni	serine/threonine RGC	0.0057	0.0042	0.0028
Echinococcus multilocularis	beta adrenergic receptor kinase	0.354	0.7646	0.9139
Echinococcus granulosus	semaphorin 1A	0.038	0.0747	0.0886
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0057	0.0042	0.0036
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0087	0.0107	1
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.2791	0.6011	0.7184
Entamoeba histolytica	protein kinase, putative	0.0087	0.0107	0.0434
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Onchocerca volvulus		0.0069	0.0067	0.0137
Brugia malayi	C-terminal src kinase protein 1	0.0057	0.0042	0.0036
Schistosoma mansoni	protein kinase	0.0076	0.0082	0.0068
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0069	0.0067	0.3838
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0067	0.0061
Brugia malayi	hypothetical protein	0.0057	0.0042	0.0036
Echinococcus multilocularis	heat shock protein 70	0.0057	0.0042	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0067	0.0061
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0057	0.0042	0.0043
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0042	0.0036
Schistosoma mansoni	serine/threonine protein kinase	0.4618	1	1
Brugia malayi	hypothetical protein	0.0057	0.0042	0.0036
Brugia malayi	A-kinase anchor protein 10, precursor	0.0749	0.1552	0.1547
Echinococcus multilocularis	Pleckstrin y	0.0069	0.0067	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0067	0.0061
Schistosoma mansoni	hypothetical protein	0.0069	0.0067	0.0053
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0057	0.0042	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0749	0.1552	1
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0079	0.0089	0.0099
Entamoeba histolytica	protein kinase , putative	0.0079	0.0089	0.031
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0069	0.0067	0.0073
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0069	0.0067	0.0061
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0057	0.0042	0.0043
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0076	0.0082	0.0091
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Entamoeba histolytica	hypothetical protein	0.0069	0.0067	0.0167
Loa Loa (eye worm)	sema domain-containing protein	0.038	0.0747	0.0741
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0057	0.0042	0.0036
Loa Loa (eye worm)	TK/ABL protein kinase	0.0057	0.0042	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0166	0.028	0.1807
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Echinococcus multilocularis	regulator of G protein signaling 3	0.0749	0.1552	0.1849
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0079	0.0089	0.031
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0069	0.0067	0.0073
Brugia malayi	plexin A	0.1062	0.2236	0.2232
Trypanosoma cruzi	hypothetical protein	0.0069	0.0067	0.3838
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0069	0.0067	0.0061
Loa Loa (eye worm)	AUR protein kinase	0.0079	0.0089	0.0083
Echinococcus granulosus	plexin a4	0.1062	0.2236	0.2668
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0168	0.0284	0.0279
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0069	0.0067	0.0431
Brugia malayi	serine/threonine protein kinase 6	0.0079	0.0089	0.0083
Leishmania major	protein kinase, putative	0.0079	0.0089	0.7147
Echinococcus multilocularis	myotubularin protein 13	0.0069	0.0067	0.0073
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Echinococcus granulosus	tyrosine protein kinase	0.0057	0.0042	0.0043
Onchocerca volvulus		0.0069	0.0067	0.0137
Schistosoma mansoni	protein kinase	0.0057	0.0042	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0067	0.0431
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0057	0.0042	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0067	0.0431
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0042	0.0036
Echinococcus granulosus	activin receptor type	0.0076	0.0082	0.0091
Loa Loa (eye worm)	TK/FAK protein kinase	0.0057	0.0042	0.0036
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0087	0.0107	1
Plasmodium vivax	hypothetical protein, conserved	0.0069	0.0067	0.3838
Plasmodium falciparum	oxysterol-binding protein, putative	0.0069	0.0067	0.3838
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Loa Loa (eye worm)	serine/threonine protein kinase	0.0057	0.0042	0.0036
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0042	0.0036
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Entamoeba histolytica	PH domain containing protein	0.0069	0.0067	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0042	0.0036
Trypanosoma cruzi	PH domain containing protein, putative	0.0069	0.0067	0.3838
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Schistosoma mansoni	protein kinase	0.0057	0.0042	0.0028
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0069	0.0067	0.0431
Schistosoma mansoni	axis inhibition protein axin	0.0749	0.1552	0.154
Plasmodium vivax	PH domain containing protein	0.0069	0.0067	0.3838
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Schistosoma mansoni	ephrin receptor	0.0057	0.0042	0.0028
Loa Loa (eye worm)	TK/ROR protein kinase	0.0057	0.0042	0.0036
Echinococcus granulosus	tyrosine protein kinase pr2	0.0057	0.0042	0.0043
Brugia malayi	SRC-1	0.0057	0.0042	0.0036
Echinococcus multilocularis	Pleckstrin y	0.0069	0.0067	0.0073
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0057	0.0042	0.0043
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0067	0.0431
Loa Loa (eye worm)	TK/RYK protein kinase	0.0057	0.0042	0.0036
Echinococcus multilocularis	axis inhibition protein axin	0.0749	0.1552	0.1849
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0069	0.0067	0.0167
Loa Loa (eye worm)	cytohesin 3	0.0069	0.0067	0.0061
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0749	0.1552	0.154
Echinococcus granulosus	Oxysterol binding protein 11	0.0069	0.0067	0.0073
Trypanosoma cruzi	hypothetical protein	0.0069	0.0067	0.3838
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0087	0.0107	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0057	0.0042	0.0043
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Echinococcus multilocularis	transcription factor collier	0.0166	0.028	0.0328
Schistosoma mansoni	semaphorin 5-related	0.038	0.0747	0.0733
Trichomonas vaginalis	conserved hypothetical protein	0.0166	0.028	0.1807
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Brugia malayi	Sema domain containing protein	0.038	0.0747	0.0741
Onchocerca volvulus		0.0069	0.0067	0.0137
Brugia malayi	DNA-binding protein LAG-1	0.0166	0.028	0.0275
Onchocerca volvulus		0.0069	0.0067	0.0137
Echinococcus granulosus	regulator of G protein signaling 3	0.0749	0.1552	0.1849
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0057	0.0042	0.0043
Brugia malayi	Pleckstrin Homology Domain	0.0069	0.0067	0.0061
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0057	0.0042	0.0036
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0057	0.0042	0.0043
Trypanosoma cruzi	hypothetical protein	0.0069	0.0067	0.3838
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Trichomonas vaginalis	conserved hypothetical protein	0.0749	0.1552	1
Schistosoma mansoni	oxysterol-binding protein 1	0.0069	0.0067	0.0053
Brugia malayi	integrin-linked kinase	0.0057	0.0042	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0067	0.0061
Echinococcus multilocularis	protein tyrosine kinase	0.0057	0.0042	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0042	0.0269
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0042	0.0036
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0057	0.0042	0.0036
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.387	0.8365	0.8364
Schistosoma mansoni	oxysterol-binding protein 1	0.0069	0.0067	0.0053
Brugia malayi	Cadps2 protein	0.0069	0.0067	0.0061
Loa Loa (eye worm)	TK/CSK protein kinase	0.0057	0.0042	0.0036
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.387	0.8365	1
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0087	0.0107	1
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Brugia malayi	IPT/TIG domain containing protein	0.0166	0.028	0.0275
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0069	0.0067	0.0167
Brugia malayi	Variant SH3 domain containing protein	0.0069	0.0067	0.0061
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0069	0.0067	0.0167
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0057	0.0042	0.0043
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0042	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0042	0.0269
Onchocerca volvulus		0.0069	0.0067	0.0137
Echinococcus multilocularis	tyrosine protein kinase csk	0.0057	0.0042	0.0043
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0069	0.0067	0.0061
Plasmodium falciparum	protein kinase, putative	0.0076	0.0082	0.6162
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0168	0.0284	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0896	0.1873	0.1868
Schistosoma mansoni	regulator of G protein signaling	0.0749	0.1552	0.154
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0069	0.0067	0.0073
Echinococcus multilocularis	regulator of G protein signaling	0.0749	0.1552	0.1849
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0042	0.0036
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0057	0.0042	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0749	0.1552	0.1547
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0069	0.0067	0.3838
Onchocerca volvulus		0.0069	0.0067	0.0137
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0067	0.0431
Entamoeba histolytica	protein kinase domain containing protein	0.0076	0.0082	0.0268
Brugia malayi	hypothetical protein	0.038	0.0747	0.0741
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Echinococcus granulosus	Pleckstrin y	0.0069	0.0067	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0067	0.0061
Schistosoma mansoni	protein kinase	0.0057	0.0042	0.0028
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0069	0.0067	0.0167
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0057	0.0042	0.0043
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0116	0.0171	0.0165
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0057	0.0042	0.0043
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0749	0.1552	0.154
Trichomonas vaginalis	protein kinase atn1, putative	0.0057	0.0042	0.0269
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0042	0.0269
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Trichomonas vaginalis	conserved hypothetical protein	0.0749	0.1552	1
Leishmania major	protein kinase, putative	0.0076	0.0082	0.6162
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0076	0.0082	0.6162
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0057	0.0042	0.0043
Brugia malayi	PH domain containing protein	0.0069	0.0067	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0042	0.0269
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0087	0.0107	0.0434
Echinococcus granulosus	Rho GTPase activating protein 24	0.0069	0.0067	0.0073
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0057	0.0042	0.0043
Plasmodium falciparum	PH domain-containing protein, putative	0.0069	0.0067	0.3838
Echinococcus multilocularis	plexin a4	0.1062	0.2236	0.2668
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0057	0.0042	0.0043
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Brugia malayi	Sema domain containing protein	0.038	0.0747	0.0741
Schistosoma mansoni	myotubularin-related protein	0.0069	0.0067	0.0053
Loa Loa (eye worm)	syntrophin-1	0.0069	0.0067	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0067	0.0061
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0111	0.016	0.0184
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0087	0.0107	0.0434
Echinococcus multilocularis	oxysterol binding protein 9	0.0069	0.0067	0.0073
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0069	0.0067	0.0073
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Schistosoma mansoni	protein kinase	0.0057	0.0042	0.0028
Trypanosoma cruzi	Protein kinase B	0.0087	0.0107	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0057	0.0042	0.0043
Brugia malayi	Fibronectin type III domain containing protein	0.0116	0.0171	0.0165
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0057	0.0042	0.0043
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0057	0.0042	0.0043
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0057	0.0042	0.0043
Brugia malayi	Uncoordinated protein 104	0.0069	0.0067	0.0061
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Brugia malayi	PH domain containing protein	0.0069	0.0067	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0749	0.1552	0.1849
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0042	0.0036
Schistosoma mansoni	serine/threonine protein kinase	0.0079	0.0089	0.0075
Echinococcus multilocularis	actin binding protein anillin	0.0069	0.0067	0.0073
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0057	0.0042	0.0043
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0057	0.0042	0.0043
Brugia malayi	regulator of G-protein signaling egl-10	0.0749	0.1552	0.1547
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Schistosoma mansoni	zinc finger protein	0.0069	0.0067	0.0053
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0171	0.0165
Loa Loa (eye worm)	sema domain-containing protein	0.038	0.0747	0.0741
Echinococcus multilocularis	activated cdc42 kinase 1	0.0057	0.0042	0.0043
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0069	0.0067	0.0167
Echinococcus granulosus	activated cdc42 kinase 1	0.0057	0.0042	0.0043
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0079	0.0089	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0166	0.028	0.0275
Entamoeba histolytica	PH domain containing protein	0.0069	0.0067	0.0167
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0069	0.0067	0.0073
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Schistosoma mansoni	hypothetical protein	0.0166	0.028	0.0267
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0057	0.0042	0.0043
Schistosoma mansoni	hypothetical protein	0.0516	0.1043	0.1031
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0749	0.1552	0.1547
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0057	0.0042	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0749	0.1552	0.1547
Loa Loa (eye worm)	hypothetical protein	0.0516	0.1043	0.1038
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0042	0.0036
Entamoeba histolytica	hypothetical protein	0.0069	0.0067	0.0167
Entamoeba histolytica	hypothetical protein	0.0749	0.1552	1
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0749	0.1552	0.1547
Echinococcus granulosus	tyrosine kinase	0.0057	0.0042	0.0043
Echinococcus multilocularis	Oxysterol binding protein 11	0.0069	0.0067	0.0073
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Schistosoma mansoni	protein kinase	0.0079	0.0089	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0067	0.0061
Echinococcus granulosus	beta-adrenergic receptor kinase	0.354	0.7646	0.9139
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0057	0.0042	0.0043
Trichomonas vaginalis	AGC family protein kinase	0.0079	0.0089	0.057
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Brugia malayi	Protein kinase domain containing protein	0.03	0.0573	0.0567
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Schistosoma mansoni	plexin	0.0516	0.1043	0.1031
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0057	0.0042	0.0043
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0069	0.0067	0.0167
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0057	0.0042	0.0043
Echinococcus granulosus	protein tyrosine kinase	0.0057	0.0042	0.0043
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Echinococcus granulosus	transcription factor collier	0.0166	0.028	0.0328
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0166	0.028	0.1807
Entamoeba histolytica	hypothetical protein	0.0069	0.0067	0.0167
Toxoplasma gondii	Oxysterol-binding protein	0.0069	0.0067	0.3838
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0087	0.0107	1
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0087	0.0107	0.0101
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0107	0.0691
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0067	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0111	0.016	0.0154
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0087	0.0107	0.0691
Schistosoma mansoni	protein kinase	0.0057	0.0042	0.0028
Brugia malayi	Guanylyl cyclase protein 23	0.0057	0.0042	0.0036
Echinococcus granulosus	G protein coupled receptor kinase 1	0.2791	0.6011	0.7184
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0166	0.028	0.1807
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0042	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Trypanosoma cruzi	hypothetical protein	0.0069	0.0067	0.3838
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0042	0.0036
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0069	0.0067	0.0167
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0042	0.0036
Loa Loa (eye worm)	TK/DDR protein kinase	0.0057	0.0042	0.0036
Echinococcus multilocularis	transfer RNA-Thr	0.0057	0.0042	0.0043
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0057	0.0042	0.0043
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0057	0.0042	0.0036
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0069	0.0067	0.0167
Schistosoma mansoni	hypothetical protein	0.0069	0.0067	0.0053
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Trichomonas vaginalis	AGC family protein kinase	0.0079	0.0089	0.057
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.387	0.8365	1
Schistosoma mansoni	z-protein (S1r protein)	0.0749	0.1552	0.154
Brugia malayi	PH domain containing protein	0.0069	0.0067	0.0061
Echinococcus granulosus	cytohesin 1	0.0069	0.0067	0.0073
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0042	0.0036
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0069	0.0067	0.0073
Loa Loa (eye worm)	TK/ACK protein kinase	0.0057	0.0042	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0042	0.0269
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0067	0.0431
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0057	0.0042	0.0043
Trypanosoma cruzi	NIMA-related kinase, putative	0.0087	0.0107	1
Echinococcus multilocularis	Immunoglobulin	0.0111	0.016	0.0184
Trypanosoma cruzi	hypothetical protein	0.0069	0.0067	0.3838
Trichomonas vaginalis	alpha chimerin, putative	0.0069	0.0067	0.0431
Entamoeba histolytica	hypothetical protein	0.0069	0.0067	0.0167
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0057	0.0042	0.0036
Loa Loa (eye worm)	rho-GTPase-activating	0.0069	0.0067	0.0061
Echinococcus multilocularis	oxysterol binding protein 1	0.0069	0.0067	0.0073
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.0042	0.0028
Trypanosoma cruzi	PH domain containing protein, putative	0.0069	0.0067	0.3838
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0069	0.0067	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0111	0.016	0.0154
Schistosoma mansoni	protein kinase	0.0057	0.0042	0.0028
Echinococcus granulosus	roundabout 2	0.0116	0.0171	0.0197
Echinococcus granulosus	regulator of G protein signaling 7	0.0749	0.1552	0.1849
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0042	0.0036
Loa Loa (eye worm)	RGS-3 protein	0.0749	0.1552	0.1547
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0057	0.0042	0.0036
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0069	0.0067	0.3838
Echinococcus granulosus	defective proboscis extension response	0.0111	0.016	0.0184
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0069	0.0067	0.0053
Schistosoma mansoni	tyrosine kinase	0.0057	0.0042	0.0028

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		Agonist activity human recombinant adenosine A1 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated adenylyl cyclase activity	ChEMBL.	19317449
Ki (binding)	= 1.56 nM	Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells	ChEMBL.	19317449
Ki (binding)	= 417 nM	Displacement of [3H]HEMADO from human recombinant adenosine A3 receptor expressed in CHO cells	ChEMBL.	19317449
Ki (binding)	= 2160 nM	Displacement of [3H]NECA from human recombinant adenosine A2A receptor expressed in CHO cells	ChEMBL.	19317449
Ki (functional)	= 4830 nM	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	ChEMBL.	19317449

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL477445

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 981804