TDR Targets

Basic information

Technical information

TDR Targets ID: 982377
Name: 4-[(2,5-difluorophenyl)amino]-6,7-dimethoxyqu inoline-3-carboxamide
MW: 359.327 | Formula: C18H15F2N3O3
H donors: 2 H acceptors: 2 LogP: 3.3 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2c(cc1OC)ncc(c2Nc1cc(F)ccc1F)C(=O)N
InChi: 1S/C18H15F2N3O3/c1-25-15-6-10-13(7-16(15)26-2)22-8-11(18(21)24)17(10)23-14-5-9(19)3-4-12(14)20/h3-8H,1-2H3,(H2,21,24)(H,22,23)
InChiKey: YMHNYVNOYXPQLO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[(2,5-difluorophenyl)amino]-6,7-dimethoxy-quinoline-3-carboxamide
4-[(2,5-difluorophenyl)amino]-6,7-dimethoxy-3-quinolinecarboxamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	colony stimulating factor 1 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	Get druggable targets OG5_132967	All targets in OG5_132967

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0056	0.0048	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0097	0.016	0.0153
Echinococcus granulosus	regulator of G protein signaling 7	0.0606	0.1535	0.1829
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0048	0.0027	0.0024
Leishmania major	serine/threonine-protein kinase a, putative	0.0071	0.0088	0.8998
Echinococcus granulosus	natriuretic peptide receptor 1	0.0048	0.0027	0.0024
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0606	0.1535	0.1529
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Echinococcus granulosus	regulator of G protein signaling 3	0.0606	0.1535	0.1829
Entamoeba histolytica	cell surface protease gp63, putative	0.0139	0.0274	0.1632
Toxoplasma gondii	hypothetical protein	0.0056	0.0048	0.299
Trichomonas vaginalis	AGC family protein kinase	0.0073	0.0095	0.062
Echinococcus granulosus	neuroglian	0.0092	0.0147	0.0167
Schistosoma mansoni	protein kinase	0.0048	0.0027	0.001
Trypanosoma brucei	protein kinase, putative	0.0071	0.0088	0.8998
Schistosoma mansoni	serine/threonine protein kinase	0.0048	0.0027	0.001
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0048	0.0041
Brugia malayi	Plekhf2 protein	0.0056	0.0048	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0211	0.0468	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0606	0.1535	0.1529
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0139	0.0274	0.1782
Onchocerca volvulus	Protein melted homolog	0.0056	0.0048	0.0107
Onchocerca volvulus	outspread protein homolog	0.0056	0.0048	0.0107
Trichomonas vaginalis	conserved hypothetical protein	0.0139	0.0274	0.1782
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0048	0.0027	0.0024
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Loa Loa (eye worm)	RGS-3 protein	0.0606	0.1535	0.1529
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Schistosoma mansoni	protein kinase	0.0063	0.0068	0.0051
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Entamoeba histolytica	protein kinase, putative	0.0073	0.0095	0.0449
Leishmania major	protein kinase, putative	0.0063	0.0068	0.6008
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0056	0.0048	0.299
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Echinococcus granulosus	regulator of G protein signaling 7	0.0606	0.1535	0.1829
Loa Loa (eye worm)	TK protein kinase	0.0048	0.0027	0.002
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0147	0.0139
Brugia malayi	PH domain containing protein	0.0056	0.0048	0.0041
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Brugia malayi	hypothetical protein	0.0318	0.0756	0.0749
Schistosoma mansoni	serine/threonine protein kinase	0.2864	0.7641	0.7637
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Loa Loa (eye worm)	plexin A	0.0886	0.2293	0.2287
Loa Loa (eye worm)	sema domain-containing protein	0.0318	0.0756	0.0749
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0048	0.0311
Echinococcus multilocularis	roundabout 2	0.0102	0.0172	0.0198
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0056	0.0048	0.0041
Schistosoma mansoni	hypothetical protein	0.0048	0.0027	0.001
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0071	0.0088	0.8998
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0048	0.0027	0.0024
Echinococcus multilocularis	dynamin 1	0.0056	0.0048	0.0049
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Echinococcus granulosus	tyrosine protein kinase csk	0.0048	0.0027	0.0024
Schistosoma mansoni	tyrosine protein kinase	0.0048	0.0027	0.001
Echinococcus granulosus	transcription factor collier	0.0139	0.0274	0.0319
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0071	0.0088	0.8998
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0056	0.0048	0.0041
Echinococcus multilocularis	axis inhibition protein axin	0.0606	0.1535	0.1829
Brugia malayi	hypothetical protein	0.0606	0.1535	0.1529
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0056	0.0048	0.0041
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0027	0.002
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0027	0.002
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0048	0.0027	0.0024
Echinococcus granulosus	insulin receptor	0.0048	0.0027	0.0024
Onchocerca volvulus		0.0056	0.0048	0.0107
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0027	0.002
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.3737	1	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0048	0.0027	0.0024
Schistosoma mansoni	goodpasture antigen-binding protein	0.0056	0.0048	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.0606	0.1535	1
Echinococcus multilocularis	aurora kinase A	0.0073	0.0095	0.0105
Brugia malayi	SH2 domain containing protein	0.0048	0.0027	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0048	0.0311
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0048	0.0027	0.0024
Echinococcus multilocularis	tyrosine protein kinase	0.0048	0.0027	0.0024
Brugia malayi	PXA domain containing protein	0.0606	0.1535	0.1529
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0056	0.0048	0.299
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0048	0.0027	0.0024
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0056	0.0048	0.0134
Schistosoma mansoni	serine/threonine protein kinase	0.2864	0.7641	0.7637
Trypanosoma cruzi	NIMA-related kinase, putative	0.0071	0.0088	0.8998
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Echinococcus granulosus	tyrosine kinase	0.0048	0.0027	0.0024
Entamoeba histolytica	p21-activated kinase	0.0071	0.0088	0.0404
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Loa Loa (eye worm)	serine/threonine protein kinase	0.0048	0.0027	0.002
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0071	0.0088	0.0404
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0048	0.0027	0.0179
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Echinococcus granulosus	Pleckstrin y	0.0056	0.0048	0.0049
Brugia malayi	serine/threonine-protein kinase 6	0.0073	0.0095	0.0088
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Brugia malayi	Variant SH3 domain containing protein	0.0056	0.0048	0.0041
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0048	0.0027	0.0179
Trichomonas vaginalis	conserved hypothetical protein	0.0139	0.0274	0.1782
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0048	0.0027	0.0024
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0027	0.002
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Entamoeba histolytica	protein kinase, putative	0.0071	0.0088	0.0404
Entamoeba histolytica	protein kinase, putative	0.0071	0.0088	0.0404
Echinococcus multilocularis	pdz domain containing protein	0.0056	0.0048	0.0049
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Echinococcus granulosus	tyrosine protein kinase	0.0048	0.0027	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0048	0.0041
Brugia malayi	hypothetical protein	0.0048	0.0027	0.002
Echinococcus multilocularis	cytohesin 1	0.0056	0.0048	0.0049
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0027	0.002
Echinococcus multilocularis	oxysterol binding protein 1	0.0056	0.0048	0.0049
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0048	0.0041
Echinococcus granulosus	beta 1 syntrophin	0.0056	0.0048	0.0049
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0071	0.0088	0.0576
Trypanosoma cruzi	hypothetical protein	0.0056	0.0048	0.299
Loa Loa (eye worm)	TK/FAK protein kinase	0.0048	0.0027	0.002
Schistosoma mansoni	serine/threonine RGC	0.0048	0.0027	0.001
Echinococcus granulosus	activin receptor type	0.0063	0.0068	0.0073
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0048	0.0027	0.0179
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0027	0.002
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0056	0.0048	0.0049
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0027	0.002
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0048	0.0027	0.002
Schistosoma mansoni	protein kinase	0.0048	0.0027	0.001
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Trypanosoma brucei	PH domain containing protein, putative	0.0056	0.0048	0.299
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0048	0.0027	0.002
Entamoeba histolytica	hypothetical protein	0.0606	0.1535	1
Onchocerca volvulus		0.0056	0.0048	0.0107
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Echinococcus granulosus	tyrosine protein kinase pr2	0.0048	0.0027	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0027	0.002
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Schistosoma mansoni	ephrin receptor	0.0048	0.0027	0.001
Trypanosoma cruzi	PH domain containing protein, putative	0.0056	0.0048	0.299
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0048	0.0027	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0048	0.0041
Trichomonas vaginalis	centaurin gamma, putative	0.0056	0.0048	0.0311
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0048	0.0027	0.0024
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0048	0.0027	0.001
Echinococcus multilocularis	regulator of G protein signaling 7	0.0606	0.1535	0.1829
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0048	0.0311
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0056	0.0048	0.0134
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0606	0.1535	0.1529
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0048	0.0027	0.002
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Echinococcus multilocularis	protein kinase	0.0048	0.0027	0.0024
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0056	0.0048	0.0134
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0056	0.0048	0.0049
Brugia malayi	Probable exocyst complex component Sec5	0.0139	0.0274	0.0267
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Schistosoma mansoni	semaphorin 5-related	0.0318	0.0756	0.074
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0145	0.0289	0.0282
Loa Loa (eye worm)	sema domain-containing protein	0.0318	0.0756	0.0749
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0048	0.0041
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0073	0.0095	0.0105
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.2258	0.6003	0.7177
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0071	0.0088	0.8998
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0056	0.0048	0.0311
Brugia malayi	PH domain containing protein	0.0056	0.0048	0.0041
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0063	0.0068	0.6008
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0048	0.0027	0.0024
Echinococcus multilocularis	beta 1 syntrophin	0.0056	0.0048	0.0049
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0048	0.0027	0.0024
Echinococcus multilocularis	c src tyrosine kinase	0.0048	0.0027	0.0024
Loa Loa (eye worm)	TK protein kinase	0.0048	0.0027	0.002
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0048	0.0027	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0048	0.0041
Echinococcus multilocularis	axis inhibition protein axin	0.0606	0.1535	0.1829
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Schistosoma mansoni	serine/threonine protein kinase	0.3737	1	1
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0606	0.1535	1
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Echinococcus multilocularis	Pleckstrin y	0.0056	0.0048	0.0049
Brugia malayi	Dynamin	0.0056	0.0048	0.0041
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0071	0.0088	0.0081
Echinococcus multilocularis	oxysterol binding protein 3	0.0056	0.0048	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0048	0.0041
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0056	0.0048	0.0107
Echinococcus multilocularis	activin receptor type	0.0063	0.0068	0.0073
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0048	0.0027	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0027	0.002
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0027	0.002
Echinococcus granulosus	semaphorin 1A	0.0318	0.0756	0.0896
Schistosoma mansoni	hypothetical protein	0.0139	0.0274	0.0257
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0606	0.1535	0.1529
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0071	0.0088	0.8998
Echinococcus multilocularis	plexin a4	0.0886	0.2293	0.2736
Echinococcus granulosus	Pleckstrin y	0.0056	0.0048	0.0049
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0056	0.0048	0.299
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Entamoeba histolytica	protein kinase, putative	0.0071	0.0088	0.0404
Brugia malayi	Syntrophin-1	0.0056	0.0048	0.0041
Echinococcus granulosus	tyrosine protein kinase HCK	0.0048	0.0027	0.0024
Entamoeba histolytica	tyrosin kinase, putative	0.0187	0.0404	0.2495
Brugia malayi	plexin A	0.0886	0.2293	0.2287
Schistosoma mansoni	serine/threonine protein kinase	0.0048	0.0027	0.001
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0048	0.0027	0.0024
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0048	0.0027	0.0024
Brugia malayi	Fibronectin type III domain containing protein	0.0097	0.016	0.0153
Toxoplasma gondii	Oxysterol-binding protein	0.0056	0.0048	0.299
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0027	0.002
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0056	0.0048	0.0049
Trichomonas vaginalis	alpha chimerin, putative	0.0056	0.0048	0.0311
Entamoeba histolytica	hypothetical protein	0.0606	0.1535	1
Schistosoma mansoni	protein kinase	0.0048	0.0027	0.001
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Trichomonas vaginalis	protein kinase atn1, putative	0.0048	0.0027	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0606	0.1535	0.1529
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0063	0.0068	0.6008
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0071	0.0088	0.0404
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0048	0.0027	0.0024
Trypanosoma cruzi	PH domain containing protein, putative	0.0056	0.0048	0.299
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0056	0.0048	0.299
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0071	0.0088	0.8998
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0027	0.0179
Echinococcus granulosus	oxysterol binding protein 1	0.0056	0.0048	0.0049
Brugia malayi	Tyrosine-protein kinase PR2	0.0048	0.0027	0.002
Echinococcus granulosus	plexin a4	0.0886	0.2293	0.2736
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0048	0.0027	0.0024
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Schistosoma mansoni	hypothetical protein	0.0056	0.0048	0.003
Echinococcus multilocularis	actin binding protein anillin	0.0056	0.0048	0.0049
Onchocerca volvulus		0.0318	0.0756	0.3856
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0092	0.0147	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0048	0.0041
Trypanosoma cruzi	aurora B kinase, putative	0.0073	0.0095	1
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0056	0.0048	0.003
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0056	0.0048	0.0134
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0071	0.0088	0.8998
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0048	0.0027	0.0024
Echinococcus granulosus	roundabout 2	0.0102	0.0172	0.0198
Loa Loa (eye worm)	TK protein kinase	0.0048	0.0027	0.002
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0048	0.0027	0.0024
Echinococcus granulosus	integrin linked protein kinase	0.0048	0.0027	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0027	0.0179
Brugia malayi	probable spectrin beta chain	0.0056	0.0048	0.0041
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0048	0.0027	0.002
Schistosoma mansoni	hypothetical protein	0.0056	0.0048	0.003
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0071	0.0088	0.8998
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0048	0.0027	0.001
Schistosoma mansoni	axis inhibition protein axin	0.0606	0.1535	0.1521
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Echinococcus granulosus	activated cdc42 kinase 1	0.0048	0.0027	0.0024
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0048	0.0027	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0606	0.1535	0.1529
Loa Loa (eye worm)	rho-GTPase-activating	0.0056	0.0048	0.0041
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0606	0.1535	0.1521
Trichomonas vaginalis	centaurin beta, putative	0.0056	0.0048	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0274	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0048	0.0041
Brugia malayi	protein-tyrosine kinase	0.0048	0.0027	0.002
Brugia malayi	Pleckstrin Homology Domain	0.0056	0.0048	0.0041
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0048	0.0027	0.0024
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0048	0.0027	0.0024
Echinococcus multilocularis	tyrosine protein kinase csk	0.0048	0.0027	0.0024
Brugia malayi	A-kinase anchor protein 10, precursor	0.0606	0.1535	0.1529
Echinococcus granulosus	cytohesin 1	0.0056	0.0048	0.0049
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Echinococcus granulosus	GRB2 associated binding protein 3	0.0056	0.0048	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0027	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0027	0.0179
Echinococcus multilocularis	tyrosine protein kinase csk	0.0048	0.0027	0.0024
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0056	0.0048	0.0049
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0048	0.0027	0.002
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.3131	0.8362	1
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.3131	0.8362	0.8361
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0027	0.002
Schistosoma mansoni	growth factor receptor-bound protein	0.0056	0.0048	0.003
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0056	0.0048	0.0041
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0048	0.0027	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0139	0.0274	0.1782
Echinococcus granulosus	Oxysterol binding protein 11	0.0056	0.0048	0.0049
Brugia malayi	PH domain containing protein	0.0056	0.0048	0.0041
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0056	0.0048	0.0107
Trichomonas vaginalis	AGC family protein kinase	0.0048	0.0027	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0027	0.002
Echinococcus granulosus	tyrosine kinase	0.0048	0.0027	0.0024
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0048	0.0027	0.0024
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0056	0.0048	0.0049
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0056	0.0048	0.0049
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0056	0.0048	0.0049
Schistosoma mansoni	z-protein (S1r protein)	0.0606	0.1535	0.1521
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0145	0.0289	0.0282
Brugia malayi	Plexin repeat family protein	0.0747	0.1917	0.1911
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0063	0.0068	0.6008
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0027	0.002
Entamoeba histolytica	protein kinase domain containing protein	0.0073	0.0095	0.0449
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0606	0.1535	0.1829
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0048	0.0041
Echinococcus granulosus	Rho GTPase activating protein 24	0.0056	0.0048	0.0049
Trichomonas vaginalis	conserved hypothetical protein	0.0606	0.1535	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0048	0.0041
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0063	0.0068	0.6008
Schistosoma mansoni	hypothetical protein	0.0318	0.0756	0.074
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Trichomonas vaginalis	conserved hypothetical protein	0.0139	0.0274	0.1782
Brugia malayi	hypothetical protein	0.0048	0.0027	0.002
Echinococcus granulosus	G protein coupled receptor kinase 1	0.2258	0.6003	0.7177
Trypanosoma cruzi	hypothetical protein	0.0056	0.0048	0.299
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0048	0.0027	0.002
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Echinococcus multilocularis	transfer RNA-Thr	0.0048	0.0027	0.0024
Echinococcus granulosus	tyrosine protein kinase csk	0.0048	0.0027	0.0024
Schistosoma mansoni	protein kinase	0.0048	0.0027	0.001
Loa Loa (eye worm)	TK/DDR protein kinase	0.0048	0.0027	0.002
Schistosoma mansoni	rho gtpase activating protein	0.0056	0.0048	0.003
Brugia malayi	Oxysterol binding protein	0.0056	0.0048	0.0041
Leishmania major	hypothetical protein, conserved	0.0056	0.0048	0.299
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Echinococcus granulosus	axis inhibition protein axin	0.0606	0.1535	0.1829
Schistosoma mansoni	oxysterol-binding protein 1	0.0056	0.0048	0.003
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.3131	0.8362	0.8361
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0071	0.0088	0.8998
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0056	0.0048	0.0041
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Echinococcus granulosus	oxysterol binding protein 3	0.0056	0.0048	0.0049
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0056	0.0048	0.0311
Leishmania major	folate/biopterin transporter, putative	0.0071	0.0088	0.8998
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Echinococcus multilocularis	protein kinase	0.0048	0.0027	0.0024
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0027	0.002
Plasmodium vivax	PH domain containing protein	0.0056	0.0048	0.299
Plasmodium falciparum	PH domain-containing protein, putative	0.0056	0.0048	0.299
Trichomonas vaginalis	protein transport protein sec7, putative	0.0056	0.0048	0.0311
Echinococcus multilocularis	Immunoglobulin	0.0092	0.0147	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0048	0.0041
Schistosoma mansoni	serine/threonine protein kinase	0.0048	0.0027	0.001
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0056	0.0048	0.0049
Echinococcus multilocularis	protein tyrosine kinase	0.0048	0.0027	0.0024
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0056	0.0048	0.299
Plasmodium falciparum	oxysterol-binding protein, putative	0.0056	0.0048	0.299
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0048	0.0027	0.002
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0097	0.016	0.0153
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Schistosoma mansoni	cell adhesion molecule	0.0102	0.0172	0.0155
Schistosoma mansoni	regulator of G protein signaling	0.0606	0.1535	0.1521
Echinococcus granulosus	regulator of G protein signaling 3	0.0606	0.1535	0.1829
Brugia malayi	Cadps2 protein	0.0056	0.0048	0.0041
Echinococcus granulosus	defective proboscis extension response	0.0092	0.0147	0.0167
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0056	0.0048	0.0041
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0048	0.0027	0.002
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0048	0.0027	0.002
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0756	0.0749
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0097	0.0159	0.0182
Brugia malayi	Uncoordinated protein 104	0.0056	0.0048	0.0041
Loa Loa (eye worm)	AUR protein kinase	0.0073	0.0095	0.0088
Entamoeba histolytica	hypothetical protein	0.0139	0.0274	0.1632
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0048	0.0027	0.0024
Toxoplasma gondii	protein kinase domain-containing protein	0.0071	0.0088	0.8998
Onchocerca volvulus		0.0056	0.0048	0.0107
Brugia malayi	DNA-binding protein LAG-1	0.0139	0.0274	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0048	0.0041
Brugia malayi	serine/threonine kinase 12	0.0073	0.0095	0.0088
Trichomonas vaginalis	centaurin/arf, putative	0.0056	0.0048	0.0311
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0048	0.0027	0.0024
Brugia malayi	regulator of G-protein signaling egl-10	0.0606	0.1535	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0429	0.1058	0.1052
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0048	0.0027	0.0024
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0027	0.002
Schistosoma mansoni	plexin	0.0429	0.1058	0.1043
Echinococcus multilocularis	regulator of G protein signaling 3	0.0606	0.1535	0.1829
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0606	0.1535	0.1829
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0056	0.0048	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0027	0.002
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0056	0.0048	0.0049
Echinococcus granulosus	axis inhibition protein axin	0.0606	0.1535	0.1829
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0048	0.0027	0.0024
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.2864	0.7641	0.764
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0048	0.0041
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0071	0.0088	0.0404
Loa Loa (eye worm)	SRC-1	0.0048	0.0027	0.002
Brugia malayi	Protein kinase domain containing protein	0.0288	0.0676	0.0669
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0048	0.0027	0.0024
Entamoeba histolytica	hypothetical protein	0.0071	0.0088	0.0404
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0548	0.1379	0.1642
Echinococcus multilocularis	neuroglian	0.0092	0.0147	0.0167
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0048	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0274	0.0267
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Echinococcus multilocularis	exocyst complex component 2	0.0139	0.0274	0.0319
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Echinococcus granulosus	protein tyrosine kinase	0.0048	0.0027	0.0024
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0048	0.0027	0.0024
Onchocerca volvulus		0.0056	0.0048	0.0107
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0048	0.0027	0.0024
Echinococcus granulosus	DCC interacting protein 13 beta	0.0056	0.0048	0.0049
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0071	0.0088	0.8998
Echinococcus multilocularis	FL cytokine receptor	0.0048	0.0027	0.0024
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0071	0.0088	0.8998
Entamoeba histolytica	protein kinase , putative	0.0073	0.0095	0.0449
Schistosoma mansoni	protein kinase	0.0048	0.0027	0.001
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0048	0.0027	0.002
Schistosoma mansoni	vesicular amine transporter	0.0095	0.0154	0.0137
Entamoeba histolytica	hypothetical protein	0.0056	0.0048	0.0134
Echinococcus granulosus	aurora kinase A	0.0073	0.0095	0.0105
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0071	0.0088	0.8998
Echinococcus granulosus	serine/threonine protein kinase	0.0071	0.0088	0.0097
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0048	0.0311
Echinococcus multilocularis	activated cdc42 kinase 1	0.0048	0.0027	0.0024
Echinococcus multilocularis	tyrosine protein kinase csk	0.0048	0.0027	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0756	0.0749
Echinococcus granulosus	ephrin type A receptor 4 A	0.0048	0.0027	0.0024
Loa Loa (eye worm)	uncoordinated protein 104	0.0056	0.0048	0.0041
Brugia malayi	Dynamin	0.0056	0.0048	0.0041
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Schistosoma mansoni	protein kinase	0.0073	0.0095	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0747	0.1917	0.1911
Schistosoma mansoni	zinc finger protein	0.0056	0.0048	0.003
Toxoplasma gondii	aurora kinase	0.0073	0.0095	1
Schistosoma mansoni	regulator of G protein signaling	0.0606	0.1535	0.1521
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0056	0.0048	0.003
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0139	0.0274	0.1782
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0071	0.0088	0.0576
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Echinococcus granulosus	epidermal growth factor receptor	0.0048	0.0027	0.0024
Echinococcus granulosus	tyrosine protein kinase Srms	0.0048	0.0027	0.0024
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0048	0.0311
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Brugia malayi	MAX-1A	0.0056	0.0048	0.0041
Schistosoma mansoni	oxysterol-binding protein 1	0.0056	0.0048	0.003
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Brugia malayi	TBC domain containing protein	0.0056	0.0048	0.0041
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Leishmania major	hypothetical protein, conserved	0.0056	0.0048	0.299
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0048	0.0027	0.002
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Loa Loa (eye worm)	AUR protein kinase	0.0073	0.0095	0.0088
Echinococcus granulosus	Pleckstrin y	0.0056	0.0048	0.0049
Schistosoma mansoni	plexin	0.0747	0.1917	0.1903
Schistosoma mansoni	hypothetical protein	0.0056	0.0048	0.003
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0048	0.0027	0.002
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0048	0.0041
Loa Loa (eye worm)	PH domain-containing protein	0.0056	0.0048	0.0041
Trichomonas vaginalis	centaurin alpha, putative	0.0056	0.0048	0.0311
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0073	0.0095	0.0449
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0073	0.0095	0.0105
Brugia malayi	ephrin receptor 1 precursor	0.0048	0.0027	0.002
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Onchocerca volvulus		0.0056	0.0048	0.0107
Loa Loa (eye worm)	TK/Met protein kinase	0.0048	0.0027	0.002
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0048	0.0027	0.002
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0056	0.0048	0.0049
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0056	0.0048	0.0311
Echinococcus multilocularis	tyrosine protein kinase csk	0.0048	0.0027	0.0024
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0056	0.0048	0.299
Trypanosoma cruzi	hypothetical protein	0.0056	0.0048	0.299
Schistosoma mansoni	serine/threonine protein kinase	0.0073	0.0095	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.0073	0.0095	0.062
Brugia malayi	Sema domain containing protein	0.0318	0.0756	0.0749
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0053	0.0041	0.004
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0048	0.0027	0.0024
Echinococcus granulosus	c src tyrosine kinase	0.0048	0.0027	0.0024
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Leishmania major	protein kinase, putative	0.0071	0.0088	0.8998
Brugia malayi	integrin-linked kinase	0.0048	0.0027	0.002
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0274	0.0267
Trypanosoma cruzi	hypothetical protein	0.0056	0.0048	0.299
Echinococcus granulosus	tyrosine protein kinase shark	0.0048	0.0027	0.0024
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Brugia malayi	SH2 domain containing protein	0.0048	0.0027	0.002
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Echinococcus granulosus	receptor type guanylyl cyclase	0.0048	0.0027	0.0024
Echinococcus multilocularis	semaphorin 5B	0.0318	0.0756	0.0896
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0056	0.0048	0.0134
Schistosoma mansoni	hypothetical protein	0.0139	0.0274	0.0257
Entamoeba histolytica	protein kinase, putative	0.0071	0.0088	0.0404
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0048	0.0027	0.0024
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0056	0.0048	0.0049
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0027	0.0179
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Brugia malayi	Guanylyl cyclase protein 23	0.0048	0.0027	0.002
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0027	0.002
Schistosoma mansoni	axis inhibition protein axin	0.0606	0.1535	0.1521
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0071	0.0088	0.8998
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0147	0.0139
Loa Loa (eye worm)	TK protein kinase	0.0048	0.0027	0.002
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Trichomonas vaginalis	AGC family protein kinase	0.0073	0.0095	0.062
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0048	0.0311
Entamoeba histolytica	hypothetical protein	0.0139	0.0274	0.1632
Trichomonas vaginalis	conserved hypothetical protein	0.0139	0.0274	0.1782
Plasmodium vivax	hypothetical protein, conserved	0.0056	0.0048	0.299
Schistosoma mansoni	protein kinase	0.0063	0.0068	0.0051
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0139	0.0274	0.1782
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Trypanosoma cruzi	hypothetical protein	0.0056	0.0048	0.299
Schistosoma mansoni	protein kinase	0.0048	0.0027	0.001
Brugia malayi	PXA domain containing protein	0.0606	0.1535	0.1529
Schistosoma mansoni	protein kinase	0.0048	0.0027	0.001
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0056	0.0048	0.0049
Schistosoma mansoni	hypothetical protein	0.0318	0.0756	0.074
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0053	0.0041	0.004
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0048	0.0027	0.002
Brugia malayi	PH domain containing protein	0.0056	0.0048	0.0041
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0071	0.0088	0.8998
Schistosoma mansoni	protein kinase	0.0048	0.0027	0.001
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Loa Loa (eye worm)	AUR protein kinase	0.0073	0.0095	0.0088
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0056	0.0048	0.0134
Echinococcus multilocularis	insulin receptor	0.0048	0.0027	0.0024
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0048	0.0027	0.0024
Loa Loa (eye worm)	TK/ACK protein kinase	0.0048	0.0027	0.002
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Loa Loa (eye worm)	TK/ALK protein kinase	0.0288	0.0676	0.0669
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0063	0.0068	0.0073
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0048	0.0027	0.0024
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0056	0.0048	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0048	0.0041
Schistosoma mansoni	hypothetical protein	0.0056	0.0048	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.0606	0.1535	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0027	0.002
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0071	0.0088	0.8998
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Echinococcus multilocularis	epidermal growth factor receptor	0.0048	0.0027	0.0024
Echinococcus multilocularis	regulator of G protein signaling 7	0.0606	0.1535	0.1829
Entamoeba histolytica	protein kinase, putative	0.0071	0.0088	0.0404
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.3131	0.8362	0.8361
Trypanosoma cruzi	Protein kinase B	0.0071	0.0088	0.8998
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0048	0.0311
Entamoeba histolytica	protein kinase, putative	0.0071	0.0088	0.0404
Schistosoma mansoni	regulator of G protein signaling	0.0606	0.1535	0.1521
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0606	0.1535	0.1829
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0071	0.0088	0.0404
Echinococcus multilocularis	Pleckstrin y	0.0056	0.0048	0.0049
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0048	0.0027	0.0024
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0048	0.0027	0.001
Echinococcus multilocularis	hypothetical protein	0.0318	0.0756	0.0896
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0056	0.0048	0.0049
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0071	0.0088	0.8998
Echinococcus granulosus	activated cdc42 kinase 1	0.0048	0.0027	0.0024
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0056	0.0048	0.0134
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0027	0.002
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Echinococcus granulosus	pdz domain containing protein	0.0056	0.0048	0.0049
Brugia malayi	PH domain containing protein	0.0056	0.0048	0.0041
Schistosoma mansoni	zinc finger protein	0.0056	0.0048	0.003
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Echinococcus granulosus	semaphorin 5B	0.0318	0.0756	0.0896
Schistosoma mansoni	dynamin	0.0056	0.0048	0.003
Trypanosoma cruzi	PH domain containing protein, putative	0.0056	0.0048	0.299
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0056	0.0048	0.003
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Entamoeba histolytica	hypothetical protein, conserved	0.0056	0.0048	0.0134
Brugia malayi	PH domain containing protein	0.0056	0.0048	0.0041
Echinococcus multilocularis	Oxysterol binding protein 11	0.0056	0.0048	0.0049
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0056	0.0048	0.299
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Brugia malayi	Sema domain containing protein	0.0318	0.0756	0.0749
Schistosoma mansoni	protein tyrosine kinase	0.0048	0.0027	0.001
Schistosoma mansoni	syntrophin	0.0056	0.0048	0.003
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0048	0.0027	0.001
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0056	0.0048	0.0311
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Echinococcus multilocularis	beta adrenergic receptor kinase	0.2864	0.7641	0.9137
Entamoeba histolytica	PH domain containing protein	0.0056	0.0048	0.0134
Brugia malayi	hypothetical protein	0.0056	0.0048	0.0041
Trichomonas vaginalis	conserved hypothetical protein	0.0606	0.1535	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0048	0.0027	0.0024
Entamoeba histolytica	hypothetical protein	0.0056	0.0048	0.0134
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0027	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0159	0.0152
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0056	0.0048	0.0049
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Plasmodium falciparum	protein kinase, putative	0.0063	0.0068	0.6008
Trypanosoma brucei	aurora B kinase	0.0073	0.0095	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.0048	0.0027	0.0024
Echinococcus multilocularis	integrin linked protein kinase	0.0048	0.0027	0.0024
Echinococcus multilocularis	tyrosine kinase	0.0048	0.0027	0.0024
Trypanosoma cruzi	hypothetical protein	0.0056	0.0048	0.299
Schistosoma mansoni	tyrosine kinase	0.0053	0.004	0.0023
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0071	0.0088	0.8998
Brugia malayi	hypothetical protein	0.0318	0.0756	0.0749
Loa Loa (eye worm)	TK/ABL protein kinase	0.0048	0.0027	0.002
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0048	0.0027	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0048	0.0311
Echinococcus multilocularis	heat shock protein 70	0.0048	0.0027	0.0024
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.3131	0.8362	1
Loa Loa (eye worm)	syntrophin-1	0.0056	0.0048	0.0041
Entamoeba histolytica	hypothetical protein	0.0056	0.0048	0.0134
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0048	0.0027	0.002
Trichomonas vaginalis	STE family protein kinase	0.0048	0.0027	0.0179
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0048	0.0027	0.0024
Brugia malayi	C-terminal src kinase protein 1	0.0048	0.0027	0.002
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0073	0.0095	1
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0073	0.0095	0.0449
Entamoeba histolytica	hypothetical protein	0.0606	0.1535	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0048	0.0027	0.002
Entamoeba histolytica	protein kinase domain containing protein	0.0063	0.0068	0.027
Schistosoma mansoni	goodpasture antigen-binding protein	0.0056	0.0048	0.003
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0048	0.0027	0.0024
Brugia malayi	hypothetical protein	0.0048	0.0027	0.002
Trypanosoma cruzi	hypothetical protein	0.0056	0.0048	0.299
Brugia malayi	SRC-1	0.0048	0.0027	0.002
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0147	0.0139
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0048	0.0027	0.002
Echinococcus granulosus	expressed protein	0.0606	0.1535	0.1829
Brugia malayi	PH domain containing protein	0.0056	0.0048	0.0041
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0056	0.0048	0.299
Brugia malayi	IPT/TIG domain containing protein	0.0139	0.0274	0.0267
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0756	0.0749
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0056	0.0048	0.299
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0056	0.0048	0.0134
Schistosoma mansoni	fibrocystin l	0.0139	0.0274	0.0257
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0048	0.0027	0.0024
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0048	0.0027	0.0024
Loa Loa (eye worm)	Plekhf2 protein	0.0056	0.0048	0.0041
Leishmania major	protein kinase, putative	0.0073	0.0095	1
Loa Loa (eye worm)	PXA domain-containing protein	0.0606	0.1535	0.1529
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Echinococcus multilocularis	regulator of G protein signaling 3	0.0606	0.1535	0.1829
Entamoeba histolytica	hypothetical protein	0.0139	0.0274	0.1632
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0048	0.0027	0.0024
Echinococcus granulosus	dynamin 1	0.0056	0.0048	0.0049
Echinococcus granulosus	Regulator of G protein signaling 20	0.0606	0.1535	0.1829
Loa Loa (eye worm)	TK protein kinase	0.0048	0.0027	0.002
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Echinococcus granulosus	exocyst complex component 2	0.0139	0.0274	0.0319
Schistosoma mansoni	myotubularin-related protein	0.0056	0.0048	0.003
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0027	0.002
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0071	0.0088	0.8998
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0048	0.0027	0.001
Loa Loa (eye worm)	hypothetical protein	0.0606	0.1535	0.1529
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0048	0.0027	0.0024
Echinococcus granulosus	raf serine:threonine protein kinase	0.0048	0.0027	0.0024
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Brugia malayi	hypothetical protein	0.0097	0.016	0.0153
Entamoeba histolytica	PH domain containing protein	0.0056	0.0048	0.0134
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0048	0.0027	0.0024
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0048	0.0027	0.0024
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0048	0.0027	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0606	0.1535	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0048	0.0027	0.002
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Schistosoma mansoni	nephrin	0.0097	0.016	0.0143
Loa Loa (eye worm)	TK protein kinase	0.0048	0.0027	0.002
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Toxoplasma gondii	hypothetical protein	0.0056	0.0048	0.299
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0071	0.0088	0.8998
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Schistosoma mansoni	regulator of G protein signaling	0.0606	0.1535	0.1521
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0048	0.0041
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0048	0.0027	0.001
Echinococcus multilocularis	tyrosine protein kinase shark	0.0048	0.0027	0.0024
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0071	0.0088	0.0404
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Brugia malayi	Variant SH3 domain containing protein	0.0056	0.0048	0.0041
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0048	0.0027	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0048	0.0311
Brugia malayi	regulator of G-protein signaling rgs-7	0.0606	0.1535	0.1529
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0056	0.0048	0.0134
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0056	0.0048	0.003
Echinococcus granulosus	twitchin	0.0107	0.0187	0.0215
Trypanosoma cruzi	PH domain containing protein, putative	0.0056	0.0048	0.299
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0159	0.0152
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0048	0.0027	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0606	0.1535	0.1529
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0056	0.0048	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0097	0.016	0.0153
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Echinococcus multilocularis	epidermal growth factor receptor	0.0048	0.0027	0.0024
Trichomonas vaginalis	TK family protein kinase	0.0048	0.0027	0.0179
Loa Loa (eye worm)	TK protein kinase	0.0048	0.0027	0.002
Echinococcus granulosus	epidermal growth factor receptor	0.0048	0.0027	0.0024
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0048	0.0027	0.002
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0056	0.0048	0.0049
Brugia malayi	Raf kinase	0.0048	0.0027	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0048	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0048	0.0041
Leishmania major	protein kinase, putative	0.0071	0.0088	0.8998
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0056	0.0048	0.0134
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0056	0.0048	0.0049
Schistosoma mansoni	ephrin receptor	0.0053	0.0041	0.0024
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0056	0.0048	0.0049
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Echinococcus granulosus	myotubularin protein 13	0.0056	0.0048	0.0049
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0027	0.002
Loa Loa (eye worm)	TK protein kinase	0.0048	0.0027	0.002
Echinococcus granulosus	protein kinase	0.0048	0.0027	0.0024
Echinococcus granulosus	beta-adrenergic receptor kinase	0.2864	0.7641	0.9137
Echinococcus multilocularis	oxysterol binding protein 9	0.0056	0.0048	0.0049
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0139	0.0274	0.1782
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0048	0.0041
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0027	0.0179
Brugia malayi	hypothetical protein	0.0606	0.1535	0.1529
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0048	0.0311
Echinococcus granulosus	tyrosine kinase	0.0048	0.0027	0.0024
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0048	0.0027	0.0024
Trichomonas vaginalis	protein transport protein sec7, putative	0.0056	0.0048	0.0311
Loa Loa (eye worm)	TK protein kinase	0.0048	0.0027	0.002
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0097	0.016	0.0153
Brugia malayi	serine/threonine protein kinase 6	0.0073	0.0095	0.0088
Entamoeba histolytica	protein kinase, putative	0.0071	0.0088	0.0404
Echinococcus multilocularis	myotubularin protein 13	0.0056	0.0048	0.0049
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0056	0.0048	0.0134
Trichomonas vaginalis	kinesin light chain, putative	0.0056	0.0048	0.0311
Schistosoma mansoni	serine/threonine protein kinase	0.0048	0.0027	0.001
Echinococcus granulosus	oxysterol binding protein 9	0.0056	0.0048	0.0049
Loa Loa (eye worm)	TK/EPH protein kinase	0.0048	0.0027	0.002
Entamoeba histolytica	protein kinase domain containing protein	0.0187	0.0404	0.2495
Echinococcus multilocularis	rac serine:threonine kinase	0.0071	0.0088	0.0097
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Schistosoma mansoni	dynamin	0.0056	0.0048	0.003
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0139	0.0274	0.1782
Loa Loa (eye worm)	TK/INSR protein kinase	0.0048	0.0027	0.002
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0048	0.0027	0.002
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0027	0.002
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0071	0.0088	0.8998
Trichomonas vaginalis	CAMK family protein kinase	0.0048	0.0027	0.0179
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0048	0.0027	0.0024
Onchocerca volvulus		0.0747	0.1917	1
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0048	0.0027	0.002
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0056	0.0048	0.0311
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Entamoeba histolytica	hypothetical protein	0.0056	0.0048	0.0134
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0056	0.0048	0.0049
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Schistosoma mansoni	serine/threonine-protein kinase	0.0071	0.0088	0.0071
Trichomonas vaginalis	AGC family protein kinase	0.0073	0.0095	0.062
Loa Loa (eye worm)	oxysterol binding protein	0.0056	0.0048	0.0041
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Loa Loa (eye worm)	TK/RYK protein kinase	0.0048	0.0027	0.002
Trichomonas vaginalis	hypothetical protein	0.0056	0.0048	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0274	0.0267
Entamoeba histolytica	hypothetical protein	0.0071	0.0088	0.0404
Onchocerca volvulus		0.0056	0.0048	0.0107
Entamoeba histolytica	protein kinase, putative	0.0073	0.0095	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0027	0.002
Echinococcus multilocularis	expressed protein	0.0606	0.1535	0.1829
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0048	0.0311
Schistosoma mansoni	hypothetical protein	0.0056	0.0048	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0027	0.0179
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0092	0.0147	0.0129
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0092	0.0147	0.0129
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0048	0.0027	0.0024
Echinococcus granulosus	pleckstrin y domain containing family A	0.0056	0.0048	0.0049
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0063	0.0068	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0159	0.0152
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0027	0.002
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Echinococcus multilocularis	Immunoglobulin	0.0092	0.0147	0.0167
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0027	0.002
Brugia malayi	Receptor family ligand binding region containing protein	0.0048	0.0027	0.002
Echinococcus multilocularis	regulator of G protein signaling	0.0606	0.1535	0.1829
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Giardia lamblia	Aurora kinase	0.0073	0.0095	1
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0756	0.0749
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0048	0.0027	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0139	0.0274	0.1782
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0048	0.0027	0.001
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0048	0.0027	0.0024
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0056	0.0048	0.0311
Loa Loa (eye worm)	cytohesin 3	0.0056	0.0048	0.0041
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Brugia malayi	Oxysterol-binding protein	0.0056	0.0048	0.0041
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0048	0.0027	0.0179
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0056	0.0048	0.0049
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0048	0.0027	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0756	0.0749
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0048	0.0027	0.0024
Trichomonas vaginalis	centaurin/arf, putative	0.0056	0.0048	0.0311
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0048	0.0027	0.0024
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Onchocerca volvulus	Putative zinc finger protein	0.0056	0.0048	0.0107
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0048	0.0311
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0056	0.0048	0.0134
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0048	0.0027	0.002
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0048	0.0041
Echinococcus multilocularis	tyrosine kinase	0.0048	0.0027	0.0024
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Loa Loa (eye worm)	TK protein kinase	0.0048	0.0027	0.002
Brugia malayi	PH domain containing protein	0.0056	0.0048	0.0041
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0056	0.0048	0.0134
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0606	0.1535	0.1529
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0048	0.0027	0.0179
Echinococcus multilocularis	Pleckstrin y	0.0056	0.0048	0.0049
Onchocerca volvulus		0.0056	0.0048	0.0107
Schistosoma mansoni	centaurin alpha	0.0056	0.0048	0.003
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0056	0.0048	0.0134
Schistosoma mansoni	hypothetical protein	0.0429	0.1058	0.1043
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Trypanosoma brucei	protein kinase, putative	0.0063	0.0068	0.6008
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Schistosoma mansoni	protein kinase	0.0063	0.0068	0.0051
Echinococcus granulosus	tyrosine protein kinase csk	0.0048	0.0027	0.0024
Echinococcus multilocularis	transcription factor collier	0.0139	0.0274	0.0319
Schistosoma mansoni	regulator of G protein signaling	0.0606	0.1535	0.1521
Loa Loa (eye worm)	TK/ROR protein kinase	0.0048	0.0027	0.002
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0756	0.0749
Entamoeba histolytica	hypothetical protein	0.0139	0.0274	0.1632
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0088	0.0576
Trichomonas vaginalis	conserved hypothetical protein	0.0606	0.1535	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0048	0.0027	0.002
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0048	0.0027	0.0024
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0027	0.002
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0048	0.0027	0.0024
Brugia malayi	PH domain containing protein	0.0056	0.0048	0.0041
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0071	0.0088	0.0404
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0606	0.1535	0.1521
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0606	0.1535	0.1521
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0048	0.0311
Trichomonas vaginalis	conserved hypothetical protein	0.0139	0.0274	0.1782
Echinococcus granulosus	Immunoglobulin	0.0092	0.0147	0.0167
Entamoeba histolytica	PH domain containing protein	0.0056	0.0048	0.0134
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0056	0.0048	0.0049
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0073	0.0095	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0048	0.0027	0.0024
Schistosoma mansoni	serine/threonine-protein kinase	0.0071	0.0088	0.0071
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0073	0.0095	0.0449
Brugia malayi	Cytohesin 3	0.0056	0.0048	0.0041
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0056	0.0048	0.0049
Trypanosoma cruzi	NIMA-related kinase, putative	0.0071	0.0088	0.8998
Toxoplasma gondii	AtPH1 family protein	0.0056	0.0048	0.299
Brugia malayi	Furin-like cysteine rich region family protein	0.0048	0.0027	0.002
Schistosoma mansoni	vav2	0.0056	0.0048	0.003
Echinococcus granulosus	calcium dependent secretion activator 1	0.0056	0.0048	0.0049
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0048	0.0311
Brugia malayi	Protein kinase domain containing protein	0.0071	0.0088	0.0081
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0048	0.0311
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0056	0.0048	0.0041
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0027	0.002
Schistosoma mansoni	tyrosine kinase	0.0048	0.0027	0.001
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0048	0.0027	0.0024
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0063	0.0068	0.0073
Trichomonas vaginalis	TKL family protein kinase	0.0048	0.0027	0.0179
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0056	0.0048	0.299
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0027	0.002
Loa Loa (eye worm)	TK/FER protein kinase	0.0048	0.0027	0.002

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 0.43 uM	Antiproliferative activity against mouse 3T3 cells expressing human CSF1R after 72 hrs by Celltiter assay	ChEMBL.	19112018
IC50 (binding)	= 0.015 uM	Inhibition of His-tagged CSF1R catalytic domain expressed in baculovirus by HTRF assay	ChEMBL.	19112018

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL480825

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 982377