TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 359.327 | Formula: C18H15F2N3O3
H donors: 2 H acceptors: 2 LogP: 3.3 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2c(cc1OC)ncc(c2Nc1cc(F)cc(c1)F)C(=O)N
InChi: 1S/C18H15F2N3O3/c1-25-15-6-12-14(7-16(15)26-2)22-8-13(18(21)24)17(12)23-11-4-9(19)3-10(20)5-11/h3-8H,1-2H3,(H2,21,24)(H,22,23)
InChiKey: SIJSEVYTHQJYDJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	colony stimulating factor 1 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	Get druggable targets OG5_132967	All targets in OG5_132967

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Echinococcus granulosus	kinase suppressor of Ras 1	0.0059	0.0041	0.0043
Onchocerca volvulus		0.0074	0.007	0.0168
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Trichomonas vaginalis	conserved hypothetical protein	0.0169	0.0265	0.1703
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0093	0.0111	0.0712
Trichomonas vaginalis	STE family protein kinase	0.0059	0.0041	0.0265
Schistosoma mansoni	protein kinase	0.0059	0.0041	0.0028
Schistosoma mansoni	vesicular amine transporter	0.013	0.0184	0.0171
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Onchocerca volvulus	Putative zinc finger protein	0.0074	0.007	0.0168
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Echinococcus multilocularis	regulator of G protein signaling 7	0.0803	0.1555	0.1853
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Entamoeba histolytica	protein kinase, putative	0.0093	0.0111	0.0459
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Echinococcus multilocularis	Pleckstrin y	0.0074	0.007	0.0078
Brugia malayi	PH domain containing protein	0.0074	0.007	0.0065
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0803	0.1555	0.155
Trichomonas vaginalis	conserved hypothetical protein	0.0169	0.0265	0.1703
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0059	0.0041	0.0265
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Loa Loa (eye worm)	PXA domain-containing protein	0.0803	0.1555	0.155
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0079	0.0082	0.5805
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Echinococcus granulosus	Pleckstrin y	0.0074	0.007	0.0078
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0059	0.0041	0.0043
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0074	0.007	0.0078
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0074	0.007	0.0078
Schistosoma mansoni	semaphorin 5-related	0.0386	0.0706	0.0694
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Entamoeba histolytica	hypothetical protein	0.0803	0.1555	1
Trichomonas vaginalis	TK family protein kinase	0.0059	0.0041	0.0265
Brugia malayi	Tyrosine-protein kinase PR2	0.0059	0.0041	0.0036
Echinococcus multilocularis	expressed protein	0.0803	0.1555	0.1853
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Schistosoma mansoni	goodpasture antigen-binding protein	0.0074	0.007	0.0057
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0093	0.0111	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0074	0.007	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0074	0.007	0.0065
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0074	0.007	0.0065
Echinococcus multilocularis	epidermal growth factor receptor	0.0059	0.0041	0.0043
Brugia malayi	Plekhf2 protein	0.0074	0.007	0.0065
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0074	0.007	0.0065
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Brugia malayi	Receptor family ligand binding region containing protein	0.0059	0.0041	0.0036
Schistosoma mansoni	protein kinase	0.0059	0.0041	0.0028
Entamoeba histolytica	protein kinase, putative	0.0093	0.0111	0.0459
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0803	0.1555	0.155
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0059	0.0041	0.0036
Echinococcus granulosus	serine/threonine protein kinase	0.0093	0.0111	0.0126
Entamoeba histolytica	hypothetical protein	0.0169	0.0265	0.1476
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0059	0.0041	0.0043
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0265	0.0259
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0059	0.0041	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0803	0.1555	0.155
Brugia malayi	serine/threonine protein kinase 6	0.0081	0.0085	0.0079
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0074	0.007	0.0193
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0074	0.007	0.0078
Schistosoma mansoni	plexin	0.091	0.1773	0.1762
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.007	0.0453
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0169	0.0265	0.1703
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0081	0.0085	0.6292
Schistosoma mansoni	tyrosine kinase	0.0064	0.0051	0.0037
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.4149	0.8366	0.8365
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0059	0.0041	0.0036
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.007	0.0193
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0059	0.0041	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0059	0.0041	0.0043
Loa Loa (eye worm)	TK/ACK protein kinase	0.0059	0.0041	0.0036
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0093	0.0111	1
Schistosoma mansoni	myotubularin-related protein	0.0074	0.007	0.0057
Brugia malayi	C-terminal src kinase protein 1	0.0059	0.0041	0.0036
Echinococcus multilocularis	axis inhibition protein axin	0.0803	0.1555	0.1853
Echinococcus multilocularis	plexin a4	0.1079	0.2117	0.2526
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0059	0.0041	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0169	0.0265	0.1703
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0074	0.007	0.0078
Echinococcus multilocularis	Immunoglobulin	0.0127	0.0179	0.0207
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0132	0.0189	0.0184
Echinococcus granulosus	cytohesin 1	0.0074	0.007	0.0078
Onchocerca volvulus	outspread protein homolog	0.0074	0.007	0.0168
Echinococcus granulosus	epidermal growth factor receptor	0.0059	0.0041	0.0043
Brugia malayi	probable spectrin beta chain	0.0074	0.007	0.0065
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0081	0.0085	0.0289
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0059	0.0041	0.0036
Schistosoma mansoni	regulator of G protein signaling	0.0803	0.1555	0.1543
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Loa Loa (eye worm)	sema domain-containing protein	0.0386	0.0706	0.0701
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0059	0.0041	0.0043
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0081	0.0085	0.0095
Brugia malayi	PH domain containing protein	0.0074	0.007	0.0065
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0059	0.0041	0.0043
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0059	0.0041	0.0036
Schistosoma mansoni	hypothetical protein	0.0386	0.0706	0.0694
Entamoeba histolytica	PH domain containing protein	0.0074	0.007	0.0193
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0074	0.007	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0074	0.007	0.4195
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0093	0.0111	0.0459
Schistosoma mansoni	hypothetical protein	0.0074	0.007	0.0057
Echinococcus granulosus	expressed protein	0.0803	0.1555	0.1853
Loa Loa (eye worm)	hypothetical protein	0.0074	0.007	0.0065
Echinococcus granulosus	G protein coupled receptor kinase 1	0.2993	0.6012	0.7185
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0041	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Entamoeba histolytica	hypothetical protein	0.0169	0.0265	0.1476
Echinococcus granulosus	insulin receptor	0.0059	0.0041	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0803	0.1555	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0059	0.0041	0.0036
Trichomonas vaginalis	kinesin light chain, putative	0.0074	0.007	0.0453
Brugia malayi	hypothetical protein	0.0074	0.007	0.0065
Brugia malayi	PH domain containing protein	0.0074	0.007	0.0065
Trypanosoma cruzi	hypothetical protein	0.0074	0.007	0.4195
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Echinococcus granulosus	tyrosine protein kinase Srms	0.0059	0.0041	0.0043
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Brugia malayi	Syntrophin-1	0.0074	0.007	0.0065
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Echinococcus multilocularis	activin receptor type	0.0079	0.0082	0.0091
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0265	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0386	0.0706	0.0701
Schistosoma mansoni	serine/threonine protein kinase	0.0059	0.0041	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.007	0.0453
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Trypanosoma cruzi	Protein kinase B	0.0093	0.0111	1
Schistosoma mansoni	protein kinase	0.0059	0.0041	0.0028
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Brugia malayi	Fibronectin type III domain containing protein	0.0132	0.0189	0.0184
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	protein transport protein sec7, putative	0.0074	0.007	0.0453
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Echinococcus multilocularis	Pleckstrin y	0.0074	0.007	0.0078
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0074	0.007	0.0193
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0074	0.007	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0074	0.007	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Echinococcus granulosus	myotubularin protein 13	0.0074	0.007	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0188	0.0183
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0059	0.0041	0.0043
Trichomonas vaginalis	AGC family protein kinase	0.0081	0.0085	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0074	0.007	0.0065
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0803	0.1555	0.1853
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Trichomonas vaginalis	hypothetical protein	0.0074	0.007	0.0453
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0074	0.007	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0803	0.1555	0.155
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0041	0.0036
Trichomonas vaginalis	alpha chimerin, putative	0.0074	0.007	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0386	0.0706	0.0701
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0265
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0074	0.007	0.0065
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.4149	0.8366	0.8365
Loa Loa (eye worm)	cytohesin 3	0.0074	0.007	0.0065
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0059	0.0041	0.0043
Echinococcus granulosus	receptor type guanylyl cyclase	0.0059	0.0041	0.0043
Leishmania major	hypothetical protein, conserved	0.0074	0.007	0.4195
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0074	0.007	0.0453
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0074	0.007	0.4195
Schistosoma mansoni	rho gtpase activating protein	0.0074	0.007	0.0057
Trypanosoma cruzi	hypothetical protein	0.0074	0.007	0.4195
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Entamoeba histolytica	protein kinase, putative	0.0093	0.0111	0.0459
Trypanosoma cruzi	hypothetical protein	0.0074	0.007	0.4195
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0059	0.0041	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0074	0.007	0.4195
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0059	0.0041	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.007	0.0453
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0041	0.0036
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0059	0.0041	0.0036
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0093	0.0111	1
Trypanosoma brucei	aurora B kinase	0.0081	0.0085	0.6292
Brugia malayi	Oxysterol binding protein	0.0074	0.007	0.0065
Echinococcus multilocularis	pdz domain containing protein	0.0074	0.007	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.007	0.0453
Echinococcus granulosus	tyrosine protein kinase csk	0.0059	0.0041	0.0043
Entamoeba histolytica	protein kinase domain containing protein	0.0228	0.0385	0.2275
Entamoeba histolytica	hypothetical protein	0.0803	0.1555	1
Echinococcus multilocularis	protein tyrosine kinase	0.0059	0.0041	0.0043
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0074	0.007	0.0453
Echinococcus multilocularis	beta 1 syntrophin	0.0074	0.007	0.0078
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0093	0.0111	1
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0265	0.0259
Brugia malayi	regulator of G-protein signaling egl-10	0.0803	0.1555	0.155
Brugia malayi	integrin-linked kinase	0.0059	0.0041	0.0036
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.007	0.0193
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0041	0.0036
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0803	0.1555	0.1543
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0064	0.0052	0.0055
Loa Loa (eye worm)	RGS-3 protein	0.0803	0.1555	0.155
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0093	0.0111	1
Loa Loa (eye worm)	sema domain-containing protein	0.0386	0.0706	0.0701
Echinococcus granulosus	ephrin type A receptor 4 A	0.0059	0.0041	0.0043
Echinococcus granulosus	axis inhibition protein axin	0.0803	0.1555	0.1853
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0059	0.0041	0.0043
Leishmania major	folate/biopterin transporter, putative	0.0093	0.0111	1
Trichomonas vaginalis	AGC family protein kinase	0.0081	0.0085	0.0546
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Brugia malayi	Raf kinase	0.0059	0.0041	0.0036
Entamoeba histolytica	hypothetical protein	0.0093	0.0111	0.0459
Echinococcus granulosus	regulator of G protein signaling 7	0.0803	0.1555	0.1853
Schistosoma mansoni	hypothetical protein	0.0386	0.0706	0.0694
Loa Loa (eye worm)	hypothetical protein	0.0074	0.007	0.0065
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Loa Loa (eye worm)	uncoordinated protein 104	0.0074	0.007	0.0065
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0059	0.0041	0.0043
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Echinococcus multilocularis	Pleckstrin y	0.0074	0.007	0.0078
Brugia malayi	DNA-binding protein LAG-1	0.0169	0.0265	0.0259
Loa Loa (eye worm)	TK/EPH protein kinase	0.0059	0.0041	0.0036
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0079	0.0082	0.0091
Loa Loa (eye worm)	TK/Met protein kinase	0.0059	0.0041	0.0036
Schistosoma mansoni	axis inhibition protein axin	0.0803	0.1555	0.1543
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0074	0.007	0.0193
Schistosoma mansoni	hypothetical protein	0.0074	0.007	0.0057
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0093	0.0111	1
Plasmodium vivax	PH domain containing protein	0.0074	0.007	0.4195
Brugia malayi	SH2 domain containing protein	0.0059	0.0041	0.0036
Entamoeba histolytica	cell surface protease gp63, putative	0.0169	0.0265	0.1476
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0803	0.1555	0.155
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Trypanosoma cruzi	NIMA-related kinase, putative	0.0093	0.0111	1
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.007	0.0453
Echinococcus granulosus	Oxysterol binding protein 11	0.0074	0.007	0.0078
Echinococcus granulosus	activin receptor type	0.0079	0.0082	0.0091
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0074	0.007	0.0078
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Echinococcus granulosus	Pleckstrin y	0.0074	0.007	0.0078
Echinococcus multilocularis	transfer RNA-Thr	0.0059	0.0041	0.0043
Echinococcus multilocularis	regulator of G protein signaling 3	0.0803	0.1555	0.1853
Loa Loa (eye worm)	TK/RYK protein kinase	0.0059	0.0041	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0074	0.007	0.0057
Schistosoma mansoni	z-protein (S1r protein)	0.0803	0.1555	0.1543
Loa Loa (eye worm)	hypothetical protein	0.0074	0.007	0.0065
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0127	0.0179	0.0166
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Echinococcus multilocularis	oxysterol binding protein 9	0.0074	0.007	0.0078
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.007	0.0193
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Brugia malayi	PH domain containing protein	0.0074	0.007	0.0065
Schistosoma mansoni	protein kinase	0.0079	0.0082	0.0068
Echinococcus multilocularis	actin binding protein anillin	0.0074	0.007	0.0078
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0059	0.0041	0.0036
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0059	0.0041	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0169	0.0265	0.1703
Echinococcus granulosus	roundabout 2	0.0137	0.0198	0.0231
Trichomonas vaginalis	centaurin gamma, putative	0.0074	0.007	0.0453
Echinococcus granulosus	c src tyrosine kinase	0.0059	0.0041	0.0043
Brugia malayi	Dynamin	0.0074	0.007	0.0065
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0127	0.0179	0.0207
Echinococcus multilocularis	aurora kinase A	0.0081	0.0085	0.0095
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Trypanosoma cruzi	hypothetical protein	0.0074	0.007	0.4195
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0041	0.0036
Echinococcus granulosus	dynamin 1	0.0074	0.007	0.0078
Schistosoma mansoni	hypothetical protein	0.0524	0.0987	0.0975
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Loa Loa (eye worm)	SRC-1	0.0059	0.0041	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0803	0.1555	1
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0059	0.0041	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.007	0.0453
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0059	0.0041	0.0043
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Echinococcus multilocularis	tyrosine protein kinase csk	0.0059	0.0041	0.0043
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0093	0.0111	1
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Echinococcus granulosus	tyrosine protein kinase HCK	0.0059	0.0041	0.0043
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0074	0.007	0.0057
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Entamoeba histolytica	hypothetical protein, conserved	0.0074	0.007	0.0193
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0093	0.0111	1
Schistosoma mansoni	vav2	0.0074	0.007	0.0057
Schistosoma mansoni	regulator of G protein signaling	0.0803	0.1555	0.1543
Schistosoma mansoni	ephrin receptor	0.0064	0.0052	0.0038
Toxoplasma gondii	Oxysterol-binding protein	0.0074	0.007	0.4195
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0559	0.1059	0.126
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0074	0.007	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Echinococcus multilocularis	roundabout 2	0.0137	0.0198	0.0231
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0059	0.0041	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.007	0.0453
Brugia malayi	TBC domain containing protein	0.0074	0.007	0.0065
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0169	0.0265	0.1703
Echinococcus granulosus	tyrosine protein kinase shark	0.0059	0.0041	0.0043
Entamoeba histolytica	hypothetical protein	0.0074	0.007	0.0193
Schistosoma mansoni	serine/threonine protein kinase	0.0059	0.0041	0.0028
Brugia malayi	PH domain containing protein	0.0074	0.007	0.0065
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0059	0.0041	0.0043
Onchocerca volvulus		0.0074	0.007	0.0168
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0803	0.1555	0.1853
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Echinococcus granulosus	tyrosine protein kinase csk	0.0059	0.0041	0.0043
Echinococcus multilocularis	tyrosine protein kinase	0.0059	0.0041	0.0043
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0074	0.007	0.0168
Schistosoma mansoni	regulator of G protein signaling	0.0803	0.1555	0.1543
Schistosoma mansoni	serine/threonine-protein kinase	0.0093	0.0111	0.0097
Entamoeba histolytica	p21-activated kinase	0.0093	0.0111	0.0459
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Onchocerca volvulus		0.0074	0.007	0.0168
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0059	0.0041	0.0043
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.3796	0.7647	0.7645
Echinococcus multilocularis	hypothetical protein	0.0386	0.0706	0.0838
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Trypanosoma cruzi	NIMA-related kinase, putative	0.0093	0.0111	1
Schistosoma mansoni	plexin	0.0524	0.0987	0.0975
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Schistosoma mansoni	regulator of G protein signaling	0.0803	0.1555	0.1543
Trypanosoma cruzi	PH domain containing protein, putative	0.0074	0.007	0.4195
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Echinococcus granulosus	neuroglian	0.0127	0.0179	0.0207
Trichomonas vaginalis	conserved hypothetical protein	0.0803	0.1555	1
Loa Loa (eye worm)	hypothetical protein	0.0386	0.0706	0.0701
Brugia malayi	serine/threonine kinase 12	0.0081	0.0085	0.0079
Schistosoma mansoni	axis inhibition protein axin	0.0803	0.1555	0.1543
Schistosoma mansoni	hypothetical protein	0.0074	0.007	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0524	0.0987	0.0982
Echinococcus granulosus	semaphorin 1A	0.0386	0.0706	0.0838
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0093	0.0111	1
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0074	0.007	0.4195
Trypanosoma brucei	protein kinase, putative	0.0079	0.0082	0.5805
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0803	0.1555	0.1543
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0074	0.007	0.0078
Schistosoma mansoni	serine/threonine protein kinase	0.3796	0.7647	0.7643
Brugia malayi	Uncoordinated protein 104	0.0074	0.007	0.0065
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0074	0.007	0.4195
Loa Loa (eye worm)	hypothetical protein	0.0074	0.007	0.0065
Echinococcus multilocularis	exocyst complex component 2	0.0169	0.0265	0.031
Echinococcus granulosus	regulator of G protein signaling 3	0.0803	0.1555	0.1853
Echinococcus granulosus	plexin a4	0.1079	0.2117	0.2526
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.007	0.0193
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0059	0.0041	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0265
Leishmania major	serine/threonine-protein kinase a, putative	0.0093	0.0111	1
Schistosoma mansoni	ephrin receptor	0.0059	0.0041	0.0028
Schistosoma mansoni	protein kinase	0.0059	0.0041	0.0028
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Brugia malayi	hypothetical protein	0.0132	0.0189	0.0184
Plasmodium falciparum	oxysterol-binding protein, putative	0.0074	0.007	0.4195
Echinococcus granulosus	natriuretic peptide receptor 1	0.0059	0.0041	0.0043
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0803	0.1555	0.1543
Loa Loa (eye worm)	TK/CSK protein kinase	0.0059	0.0041	0.0036
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Echinococcus granulosus	beta 1 syntrophin	0.0074	0.007	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0074	0.007	0.0065
Entamoeba histolytica	protein kinase, putative	0.0093	0.0111	0.0459
Echinococcus granulosus	beta-adrenergic receptor kinase	0.3796	0.7647	0.914
Plasmodium vivax	hypothetical protein, conserved	0.0074	0.007	0.4195
Echinococcus granulosus	Rho GTPase activating protein 24	0.0074	0.007	0.0078
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0169	0.0265	0.1703
Loa Loa (eye worm)	hypothetical protein	0.0386	0.0706	0.0701
Entamoeba histolytica	PH domain containing protein	0.0074	0.007	0.0193
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0059	0.0041	0.0265
Schistosoma mansoni	serine/threonine protein kinase	0.0081	0.0085	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0188	0.0183
Trichomonas vaginalis	conserved hypothetical protein	0.0803	0.1555	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0059	0.0041	0.0043
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0059	0.0041	0.0036
Toxoplasma gondii	hypothetical protein	0.0074	0.007	0.4195
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0059	0.0041	0.0043
Trypanosoma brucei	PH domain containing protein, putative	0.0074	0.007	0.4195
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0093	0.0111	0.0105
Brugia malayi	Plexin repeat family protein	0.091	0.1773	0.1768
Leishmania major	hypothetical protein, conserved	0.0074	0.007	0.4195
Echinococcus multilocularis	tyrosine protein kinase csk	0.0059	0.0041	0.0043
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0093	0.0111	0.0459
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0074	0.007	0.0168
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0803	0.1555	0.155
Echinococcus multilocularis	semaphorin 5B	0.0386	0.0706	0.0838
Brugia malayi	PH domain containing protein	0.0074	0.007	0.0065
Brugia malayi	Cadps2 protein	0.0074	0.007	0.0065
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0074	0.007	0.4195
Echinococcus multilocularis	protein kinase	0.0059	0.0041	0.0043
Brugia malayi	Sema domain containing protein	0.0386	0.0706	0.0701
Echinococcus multilocularis	myotubularin protein 13	0.0074	0.007	0.0078
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0059	0.0041	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Echinococcus granulosus	tyrosine kinase	0.0059	0.0041	0.0043
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0803	0.1555	1
Echinococcus granulosus	axis inhibition protein axin	0.0803	0.1555	0.1853
Echinococcus granulosus	Immunoglobulin	0.0127	0.0179	0.0207
Brugia malayi	Guanylyl cyclase protein 23	0.0059	0.0041	0.0036
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0059	0.0041	0.0043
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0064	0.0052	0.0055
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0059	0.0041	0.0043
Trichomonas vaginalis	protein transport protein sec7, putative	0.0074	0.007	0.0453
Echinococcus multilocularis	tyrosine protein kinase csk	0.0059	0.0041	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0169	0.0265	0.1703
Schistosoma mansoni	protein kinase	0.0059	0.0041	0.0028
Leishmania major	protein kinase, putative	0.0093	0.0111	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0059	0.0041	0.0043
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0074	0.007	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Loa Loa (eye worm)	plexin A	0.1079	0.2117	0.2113
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0093	0.0111	1
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0074	0.007	0.4195
Entamoeba histolytica	hypothetical protein	0.0074	0.007	0.0193
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0059	0.0041	0.0043
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0074	0.007	0.0078
Brugia malayi	PH domain containing protein	0.0074	0.007	0.0065
Brugia malayi	Pleckstrin Homology Domain	0.0074	0.007	0.0065
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0074	0.007	0.0078
Brugia malayi	Variant SH3 domain containing protein	0.0074	0.007	0.0065
Echinococcus multilocularis	insulin receptor	0.0059	0.0041	0.0043
Echinococcus granulosus	integrin linked protein kinase	0.0059	0.0041	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0074	0.007	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0386	0.0706	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0093	0.0111	1
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.007	0.0453
Echinococcus granulosus	activated cdc42 kinase 1	0.0059	0.0041	0.0043
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.007	0.0453
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0074	0.007	0.0078
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0079	0.0082	0.5805
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0059	0.0041	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0074	0.007	0.0065
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0074	0.007	0.0193
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0059	0.0041	0.0028
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0059	0.0041	0.0043
Echinococcus granulosus	Pleckstrin y	0.0074	0.007	0.0078
Schistosoma mansoni	centaurin alpha	0.0074	0.007	0.0057
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Echinococcus multilocularis	rac serine:threonine kinase	0.0093	0.0111	0.0126
Brugia malayi	Protein kinase domain containing protein	0.0093	0.0111	0.0105
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0074	0.007	0.0078
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0059	0.0041	0.0265
Echinococcus multilocularis	activated cdc42 kinase 1	0.0059	0.0041	0.0043
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Entamoeba histolytica	protein kinase , putative	0.0081	0.0085	0.0289
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Echinococcus granulosus	activated cdc42 kinase 1	0.0059	0.0041	0.0043
Trichomonas vaginalis	centaurin/arf, putative	0.0074	0.007	0.0453
Echinococcus granulosus	calcium dependent secretion activator 1	0.0074	0.007	0.0078
Trypanosoma cruzi	PH domain containing protein, putative	0.0074	0.007	0.4195
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Echinococcus granulosus	defective proboscis extension response	0.0127	0.0179	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0093	0.0111	1
Entamoeba histolytica	protein kinase, putative	0.0093	0.0111	0.0459
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Echinococcus granulosus	tyrosine protein kinase pr2	0.0059	0.0041	0.0043
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0059	0.0041	0.0043
Echinococcus multilocularis	tyrosine protein kinase csk	0.0059	0.0041	0.0043
Brugia malayi	plexin A	0.1079	0.2117	0.2113
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0059	0.0041	0.0036
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.007	0.0193
Loa Loa (eye worm)	TK/ROR protein kinase	0.0059	0.0041	0.0036
Entamoeba histolytica	hypothetical protein	0.0074	0.007	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0803	0.1555	0.155
Brugia malayi	regulator of G-protein signaling rgs-7	0.0803	0.1555	0.155
Echinococcus granulosus	semaphorin 5B	0.0386	0.0706	0.0838
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0059	0.0041	0.0043
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0059	0.0041	0.0028
Trichomonas vaginalis	centaurin/arf, putative	0.0074	0.007	0.0453
Brugia malayi	Protein kinase domain containing protein	0.0306	0.0543	0.0538
Schistosoma mansoni	protein kinase	0.0059	0.0041	0.0028
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.4149	0.8366	0.8365
Schistosoma mansoni	serine/threonine protein kinase	0.0059	0.0041	0.0028
Schistosoma mansoni	zinc finger protein	0.0074	0.007	0.0057
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0059	0.0041	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.007	0.0453
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Schistosoma mansoni	protein kinase	0.0059	0.0041	0.0028
Trypanosoma cruzi	aurora B kinase, putative	0.0081	0.0085	0.6292
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0093	0.0111	0.0459
Echinococcus granulosus	twitchin	0.0147	0.0219	0.0255
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0093	0.0111	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0059	0.0041	0.0043
Loa Loa (eye worm)	serine/threonine protein kinase	0.0059	0.0041	0.0036
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Loa Loa (eye worm)	TK/DDR protein kinase	0.0059	0.0041	0.0036
Echinococcus multilocularis	c src tyrosine kinase	0.0059	0.0041	0.0043
Schistosoma mansoni	growth factor receptor-bound protein	0.0074	0.007	0.0057
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0059	0.0041	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0074	0.007	0.0065
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0059	0.0041	0.0043
Brugia malayi	Furin-like cysteine rich region family protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0179	0.0173
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0059	0.0041	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0074	0.007	0.0065
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0191	0.0309	0.0303
Echinococcus multilocularis	heat shock protein 70	0.0059	0.0041	0.0043
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0074	0.007	0.0065
Schistosoma mansoni	protein tyrosine kinase	0.0059	0.0041	0.0028
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Echinococcus granulosus	GRB2 associated binding protein 3	0.0074	0.007	0.0078
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0074	0.007	0.0078
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0079	0.0082	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0188	0.0183
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0059	0.0041	0.0043
Schistosoma mansoni	hypothetical protein	0.0169	0.0265	0.0252
Trypanosoma cruzi	hypothetical protein	0.0074	0.007	0.4195
Trypanosoma cruzi	hypothetical protein	0.0074	0.007	0.4195
Echinococcus granulosus	pdz domain containing protein	0.0074	0.007	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0803	0.1555	0.155
Leishmania major	protein kinase, putative	0.0081	0.0085	0.6292
Brugia malayi	hypothetical protein	0.0386	0.0706	0.0701
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.007	0.0453
Schistosoma mansoni	goodpasture antigen-binding protein	0.0074	0.007	0.0057
Echinococcus granulosus	tyrosine kinase	0.0059	0.0041	0.0043
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0059	0.0041	0.0043
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0093	0.0111	1
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Schistosoma mansoni	fibrocystin l	0.0169	0.0265	0.0252
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Trichomonas vaginalis	conserved hypothetical protein	0.0169	0.0265	0.1703
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0093	0.0111	1
Schistosoma mansoni	dynamin	0.0074	0.007	0.0057
Brugia malayi	PH domain containing protein	0.0074	0.007	0.0065
Echinococcus granulosus	protein kinase	0.0059	0.0041	0.0043
Schistosoma mansoni	syntrophin	0.0074	0.007	0.0057
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Echinococcus multilocularis	dynamin 1	0.0074	0.007	0.0078
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Brugia malayi	PH domain containing protein	0.0074	0.007	0.0065
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0074	0.007	0.0078
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0074	0.007	0.0065
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.007	0.0453
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Loa Loa (eye worm)	AUR protein kinase	0.0081	0.0085	0.0079
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0074	0.007	0.0078
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.007	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0189	0.0184
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0041	0.0036
Echinococcus granulosus	oxysterol binding protein 1	0.0074	0.007	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0179	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0074	0.007	0.0065
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0074	0.007	0.0078
Schistosoma mansoni	serine/threonine RGC	0.0059	0.0041	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.007	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0041	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0074	0.007	0.0065
Echinococcus granulosus	Regulator of G protein signaling 20	0.0803	0.1555	0.1853
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Loa Loa (eye worm)	TK/FAK protein kinase	0.0059	0.0041	0.0036
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0059	0.0041	0.0028
Echinococcus multilocularis	oxysterol binding protein 1	0.0074	0.007	0.0078
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.007	0.0453
Trypanosoma cruzi	PH domain containing protein, putative	0.0074	0.007	0.4195
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0169	0.0265	0.1703
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.007	0.0453
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0059	0.0041	0.0036
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0059	0.0041	0.0043
Trichomonas vaginalis	centaurin beta, putative	0.0074	0.007	0.0453
Echinococcus multilocularis	regulator of G protein signaling 3	0.0803	0.1555	0.1853
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0093	0.0111	0.0459
Brugia malayi	serine/threonine-protein kinase 6	0.0081	0.0085	0.0079
Trichomonas vaginalis	conserved hypothetical protein	0.0169	0.0265	0.1703
Toxoplasma gondii	AtPH1 family protein	0.0074	0.007	0.4195
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Onchocerca volvulus		0.0386	0.0706	0.384
Echinococcus multilocularis	beta adrenergic receptor kinase	0.3796	0.7647	0.914
Echinococcus granulosus	transcription factor collier	0.0169	0.0265	0.031
Brugia malayi	PXA domain containing protein	0.0803	0.1555	0.155
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0059	0.0041	0.0036
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0059	0.0041	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Entamoeba histolytica	PH domain containing protein	0.0074	0.007	0.0193
Schistosoma mansoni	dynamin	0.0074	0.007	0.0057
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0189	0.0184
Echinococcus multilocularis	tyrosine protein kinase shark	0.0059	0.0041	0.0043
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Echinococcus multilocularis	oxysterol binding protein 3	0.0074	0.007	0.0078
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0074	0.007	0.0065
Trichomonas vaginalis	CAMK family protein kinase	0.0059	0.0041	0.0265
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0059	0.0041	0.0043
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0074	0.007	0.0078
Loa Loa (eye worm)	syntrophin-1	0.0074	0.007	0.0065
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0059	0.0041	0.0043
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0074	0.007	0.4195
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0074	0.007	0.4195
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Brugia malayi	A-kinase anchor protein 10, precursor	0.0803	0.1555	0.155
Echinococcus granulosus	pleckstrin y domain containing family A	0.0074	0.007	0.0078
Echinococcus granulosus	epidermal growth factor receptor	0.0059	0.0041	0.0043
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0059	0.0041	0.0043
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0059	0.0041	0.0043
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0074	0.007	0.0453
Loa Loa (eye worm)	Plekhf2 protein	0.0074	0.007	0.0065
Entamoeba histolytica	protein kinase, putative	0.0093	0.0111	0.0459
Brugia malayi	Variant SH3 domain containing protein	0.0074	0.007	0.0065
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Trichomonas vaginalis	AGC family protein kinase	0.0081	0.0085	0.0546
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0059	0.0041	0.0036
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.007	0.0193
Trichomonas vaginalis	AGC family protein kinase	0.0081	0.0085	0.0546
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0059	0.0041	0.0036
Brugia malayi	hypothetical protein	0.0803	0.1555	0.155
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0059	0.0041	0.0043
Entamoeba histolytica	protein kinase, putative	0.0081	0.0085	0.0289
Plasmodium falciparum	protein kinase, putative	0.0079	0.0082	0.5805
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0074	0.007	0.0078
Toxoplasma gondii	aurora kinase	0.0081	0.0085	0.6292
Brugia malayi	Dynamin	0.0074	0.007	0.0065
Echinococcus multilocularis	epidermal growth factor receptor	0.0059	0.0041	0.0043
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0265
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0191	0.0309	0.0303
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0059	0.0041	0.0043
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0041	0.0036
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0081	0.0085	0.0095
Brugia malayi	hypothetical protein	0.0803	0.1555	0.155
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Echinococcus granulosus	protein tyrosine kinase	0.0059	0.0041	0.0043
Echinococcus granulosus	tyrosine kinase	0.0059	0.0041	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0386	0.0706	0.0701
Entamoeba histolytica	hypothetical protein	0.0803	0.1555	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0059	0.0041	0.0043
Brugia malayi	Sema domain containing protein	0.0386	0.0706	0.0701
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0803	0.1555	0.155
Echinococcus granulosus	regulator of G protein signaling 3	0.0803	0.1555	0.1853
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0059	0.0041	0.0043
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0059	0.0041	0.0265
Schistosoma mansoni	hypothetical protein	0.0074	0.007	0.0057
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Entamoeba histolytica	hypothetical protein	0.0169	0.0265	0.1476
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0059	0.0041	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.007	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Schistosoma mansoni	protein kinase	0.0081	0.0085	0.0072
Echinococcus granulosus	tyrosine protein kinase	0.0059	0.0041	0.0043
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0081	0.0085	0.0289
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0074	0.007	0.0078
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0093	0.0111	1
Leishmania major	protein kinase, putative	0.0079	0.0082	0.5805
Schistosoma mansoni	regulator of G protein signaling	0.0803	0.1555	0.1543
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.007	0.0193
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0074	0.007	0.0078
Loa Loa (eye worm)	rho-GTPase-activating	0.0074	0.007	0.0065
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Entamoeba histolytica	protein kinase domain containing protein	0.0081	0.0085	0.0289
Brugia malayi	Probable exocyst complex component Sec5	0.0169	0.0265	0.0259
Schistosoma mansoni	hypothetical protein	0.0169	0.0265	0.0252
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0059	0.0041	0.0043
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0074	0.007	0.0078
Brugia malayi	Tyrosine-protein kinase abl-1	0.0059	0.0041	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.2993	0.6012	0.7185
Echinococcus multilocularis	regulator of G protein signaling 7	0.0803	0.1555	0.1853
Brugia malayi	MAX-1A	0.0074	0.007	0.0065
Trichomonas vaginalis	protein kinase atn1, putative	0.0059	0.0041	0.0265
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0059	0.0041	0.0043
Toxoplasma gondii	hypothetical protein	0.0074	0.007	0.4195
Loa Loa (eye worm)	TK/ALK protein kinase	0.0306	0.0543	0.0538
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0074	0.007	0.0193
Schistosoma mansoni	serine/threonine protein kinase	0.0059	0.0041	0.0028
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0127	0.0179	0.0166
Brugia malayi	hypothetical protein	0.0386	0.0706	0.0701
Schistosoma mansoni	serine/threonine-protein kinase	0.0093	0.0111	0.0097
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0081	0.0085	0.0289
Brugia malayi	SRC-1	0.0059	0.0041	0.0036
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0074	0.007	0.0453
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0074	0.007	0.0057
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0059	0.0041	0.0043
Schistosoma mansoni	nephrin	0.0132	0.0189	0.0176
Entamoeba histolytica	protein kinase, putative	0.0093	0.0111	0.0459
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Schistosoma mansoni	protein kinase	0.0059	0.0041	0.0028
Onchocerca volvulus		0.0074	0.007	0.0168
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0081	0.0085	0.6292
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Echinococcus granulosus	exocyst complex component 2	0.0169	0.0265	0.031
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.4952	1	1
Leishmania major	protein kinase, putative	0.0093	0.0111	1
Brugia malayi	protein-tyrosine kinase	0.0059	0.0041	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0265
Schistosoma mansoni	serine/threonine protein kinase	0.4952	1	1
Loa Loa (eye worm)	oxysterol binding protein	0.0074	0.007	0.0065
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0079	0.0082	0.5805
Brugia malayi	ephrin receptor 1 precursor	0.0059	0.0041	0.0036
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.007	0.0193
Echinococcus multilocularis	FL cytokine receptor	0.0059	0.0041	0.0043
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0093	0.0111	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0041	0.0265
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0059	0.0041	0.0028
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0059	0.0041	0.0043
Brugia malayi	Oxysterol-binding protein	0.0074	0.007	0.0065
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0059	0.0041	0.0028
Brugia malayi	PXA domain containing protein	0.0803	0.1555	0.155
Echinococcus multilocularis	cytohesin 1	0.0074	0.007	0.0078
Schistosoma mansoni	oxysterol-binding protein 1	0.0074	0.007	0.0057
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0265
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Trypanosoma brucei	protein kinase, putative	0.0093	0.0111	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Schistosoma mansoni	cell adhesion molecule	0.0137	0.0198	0.0185
Brugia malayi	hypothetical protein	0.0059	0.0041	0.0036
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0059	0.0041	0.0043
Onchocerca volvulus		0.091	0.1773	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0059	0.0041	0.0043
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Brugia malayi	SH2 domain containing protein	0.0059	0.0041	0.0036
Echinococcus multilocularis	transcription factor collier	0.0169	0.0265	0.031
Trypanosoma cruzi	hypothetical protein	0.0074	0.007	0.4195
Brugia malayi	hypothetical protein	0.0059	0.0041	0.0036
Giardia lamblia	Aurora kinase	0.0081	0.0085	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0059	0.0041	0.0028
Entamoeba histolytica	tyrosin kinase, putative	0.0228	0.0385	0.2275
Schistosoma mansoni	oxysterol-binding protein 1	0.0074	0.007	0.0057
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0079	0.0082	0.0091
Plasmodium falciparum	PH domain-containing protein, putative	0.0074	0.007	0.4195
Loa Loa (eye worm)	hypothetical protein	0.0074	0.007	0.0065
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0217	0.0362	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0074	0.007	0.0065
Toxoplasma gondii	protein kinase domain-containing protein	0.0093	0.0111	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0036
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Echinococcus multilocularis	neuroglian	0.0127	0.0179	0.0207
Loa Loa (eye worm)	TK/INSR protein kinase	0.0059	0.0041	0.0036
Brugia malayi	Cytohesin 3	0.0074	0.007	0.0065
Schistosoma mansoni	protein kinase	0.0079	0.0082	0.0068
Loa Loa (eye worm)	hypothetical protein	0.091	0.1773	0.1768
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0059	0.0041	0.0036
Loa Loa (eye worm)	AUR protein kinase	0.0081	0.0085	0.0079
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Echinococcus granulosus	tyrosine protein kinase Blk	0.0059	0.0041	0.0043
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0074	0.007	0.0078
Entamoeba histolytica	hypothetical protein	0.0093	0.0111	0.0459
Loa Loa (eye worm)	TK/FER protein kinase	0.0059	0.0041	0.0036
Echinococcus granulosus	raf serine:threonine protein kinase	0.0059	0.0041	0.0043
Schistosoma mansoni	zinc finger protein	0.0074	0.007	0.0057
Schistosoma mansoni	tyrosine protein kinase	0.0059	0.0041	0.0028
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0803	0.1555	0.1853
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Loa Loa (eye worm)	AUR protein kinase	0.0081	0.0085	0.0079
Echinococcus granulosus	oxysterol binding protein 9	0.0074	0.007	0.0078
Loa Loa (eye worm)	TK/ABL protein kinase	0.0059	0.0041	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0189	0.0184
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0074	0.007	0.4195
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0265	0.0259
Brugia malayi	hypothetical protein	0.0059	0.0041	0.0036
Schistosoma mansoni	hypothetical protein	0.0074	0.007	0.0057
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0265
Entamoeba histolytica	protein kinase, putative	0.0081	0.0085	0.0289
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0079	0.0082	0.5805
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0093	0.0111	0.0459
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0059	0.0041	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0074	0.007	0.0065
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0093	0.0111	1
Onchocerca volvulus		0.0074	0.007	0.0168
Echinococcus multilocularis	Immunoglobulin	0.0127	0.0179	0.0207
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0093	0.0111	0.0712
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0059	0.0041	0.0043
Schistosoma mansoni	serine/threonine protein kinase	0.3796	0.7647	0.7643
Echinococcus multilocularis	Oxysterol binding protein 11	0.0074	0.007	0.0078
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0059	0.0041	0.0043
Echinococcus granulosus	DCC interacting protein 13 beta	0.0074	0.007	0.0078
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Schistosoma mansoni	hypothetical protein	0.0059	0.0041	0.0028
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0041	0.0036
Onchocerca volvulus		0.0074	0.007	0.0168
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0074	0.007	0.0453
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0179	0.0173
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0059	0.0041	0.0028
Echinococcus granulosus	tyrosine protein kinase csk	0.0059	0.0041	0.0043
Brugia malayi	IPT/TIG domain containing protein	0.0169	0.0265	0.0259
Trichomonas vaginalis	AGC family protein kinase	0.0093	0.0111	0.0712
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.4149	0.8366	1
Entamoeba histolytica	protein kinase domain containing protein	0.0079	0.0082	0.0266
Entamoeba histolytica	hypothetical protein	0.0169	0.0265	0.1476
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0074	0.007	0.0193
Echinococcus multilocularis	tyrosine kinase	0.0059	0.0041	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0265
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0059	0.0041	0.0043
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0059	0.0041	0.0043
Schistosoma mansoni	tyrosine kinase	0.0059	0.0041	0.0028
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0169	0.0265	0.1703
Echinococcus granulosus	regulator of G protein signaling 7	0.0803	0.1555	0.1853
Onchocerca volvulus	Protein melted homolog	0.0074	0.007	0.0168
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0059	0.0041	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0803	0.1555	1
Onchocerca volvulus		0.0074	0.007	0.0168
Entamoeba histolytica	hypothetical protein	0.0074	0.007	0.0193
Echinococcus multilocularis	integrin linked protein kinase	0.0059	0.0041	0.0043
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0059	0.0041	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0074	0.007	0.0065
Schistosoma mansoni	protein kinase	0.0079	0.0082	0.0068
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.4149	0.8366	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0059	0.0041	0.0043
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0059	0.0041	0.0036
Trichomonas vaginalis	centaurin alpha, putative	0.0074	0.007	0.0453
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0132	0.0188	0.0218
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0059	0.0041	0.0043
Echinococcus multilocularis	regulator of G protein signaling	0.0803	0.1555	0.1853
Entamoeba histolytica	hypothetical protein	0.0074	0.007	0.0193
Loa Loa (eye worm)	TK protein kinase	0.0059	0.0041	0.0036
Echinococcus granulosus	oxysterol binding protein 3	0.0074	0.007	0.0078
Echinococcus multilocularis	protein kinase	0.0059	0.0041	0.0043
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0093	0.0111	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0059	0.0041	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.007	0.0453
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0074	0.007	0.0057
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0074	0.007	0.0065
Echinococcus multilocularis	axis inhibition protein axin	0.0803	0.1555	0.1853
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0059	0.0041	0.0265
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0041	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0803	0.1555	1
Echinococcus granulosus	aurora kinase A	0.0081	0.0085	0.0095
Loa Loa (eye worm)	PH domain-containing protein	0.0074	0.007	0.0065
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0093	0.0111	1
Trypanosoma cruzi	PH domain containing protein, putative	0.0074	0.007	0.4195
Echinococcus multilocularis	tyrosine kinase	0.0059	0.0041	0.0043
Trichomonas vaginalis	TKL family protein kinase	0.0059	0.0041	0.0265

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 1.2 uM	Antiproliferative activity against mouse 3T3 cells expressing human CSF1R after 72 hrs by Celltiter assay	ChEMBL.	19112018
IC50 (binding)	= 0.1 uM	Inhibition of His-tagged CSF1R catalytic domain expressed in baculovirus by HTRF assay	ChEMBL.	19112018

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL480826

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 982378