Detailed information for compound 983430

Basic information

Technical information
  • TDR Targets ID: 983430
  • Name: 1,7-dimethoxy-6-methyl-9,10-dihydrophenanthre ne-2,5-diol
  • MW: 286.322 | Formula: C17H18O4
  • H donors: 2 H acceptors: 2 LogP: 3.44 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2CCc3c(c2c(c1C)O)ccc(c3OC)O
  • InChi: 1S/C17H18O4/c1-9-14(20-2)8-10-4-5-12-11(15(10)16(9)19)6-7-13(18)17(12)21-3/h6-8,18-19H,4-5H2,1-3H3
  • InChiKey: QQDAIOAKEGCALE-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tubulin alpha chain 0.1559 0.7476 0.7476
Trypanosoma brucei beta tubulin 0.2081 1 1
Trypanosoma cruzi zeta tubulin, putative 0.1643 0.7882 0.788
Echinococcus multilocularis tubulin alpha 3 chain 0.1559 0.7476 0.7476
Giardia lamblia Alpha-tubulin 0.1559 0.7476 0.7363
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0225 0.0225
Brugia malayi tubulin alpha-2 chain 0.1559 0.7476 0.7476
Trypanosoma brucei beta tubulin 0.2081 1 1
Leishmania major alpha tubulin 0.1559 0.7476 0.7474
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0007 0.0024
Brugia malayi Muscleblind-like protein 0.0151 0.0664 0.0664
Echinococcus multilocularis beta tubulin 0.2081 1 1
Plasmodium falciparum tubulin gamma chain 0.1274 0.6095 0.478
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0008 0.0008
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0075 0.0075
Echinococcus granulosus transcription factor Dp 1 0.0078 0.0311 0.0311
Brugia malayi hypothetical protein 0.0015 0.0008 0.0008
Echinococcus multilocularis transcription factor Dp 1 0.0078 0.0311 0.0311
Leishmania major alpha tubulin 0.1559 0.7476 0.7474
Leishmania major beta tubulin 0.2081 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.2081 1 1
Leishmania major cytochrome p450-like protein 0.0025 0.0053 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0075 0.0075
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.0853 0.0853
Trichomonas vaginalis tubulin beta chain, putative 0.1559 0.7476 0.7449
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0075 0.0075
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.0853 0.0853
Echinococcus multilocularis Tubulin alpha 1 chain 0.1559 0.7476 0.7476
Trichomonas vaginalis tubulin epsilon chain, putative 0.0535 0.2519 0.244
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0007 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0163 0.0163
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0075 0.025
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0134 0.0134
Loa Loa (eye worm) tubulin alpha-2 chain 0.1559 0.7476 0.7476
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0075 0.0075
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0075 0.0075
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0075 0.0075
Leishmania major beta tubulin 0.2081 1 1
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0167 0.0167
Echinococcus multilocularis tubulin alpha chain 0.1559 0.7476 0.7476
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0102 0.0428 0.042
Brugia malayi Bromodomain containing protein 0.0076 0.03 0.03
Echinococcus multilocularis jun protein 0.0089 0.0365 0.0365
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0075 0.0075
Toxoplasma gondii alpha-tubulin I, putative 0.1559 0.7476 0.7456
Brugia malayi Tubulin gamma chain 0.1274 0.6095 0.6095
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0102 0.0428 0.0351
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0053 0.0053
Treponema pallidum cell division protein FtsZ 0.0535 0.2519 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0075 0.0075
Brugia malayi Tubulin alpha-2 chain 0.1559 0.7476 0.7476
Loa Loa (eye worm) hypothetical protein 0.0039 0.0121 0.0121
Schistosoma mansoni tubulin subunit epsilon 0.1272 0.6087 0.6087
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0075 0.0075
Trypanosoma brucei beta tubulin 0.2081 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.1089 0.1089
Onchocerca volvulus 0.0029 0.0075 0.025
Loa Loa (eye worm) BEN-1 protein 0.2081 1 1
Leishmania major delta tubulin, putative 0.1198 0.5727 0.5724
Leishmania major alpha tubulin 0.1559 0.7476 0.7474
Loa Loa (eye worm) hypothetical protein 0.0029 0.0075 0.0075
Echinococcus granulosus tubulin subunit beta 0.2081 1 1
Schistosoma mansoni alpha tubulin 0.1559 0.7476 0.7476
Leishmania major alpha tubulin 0.1559 0.7476 0.7474
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0167 0.0167
Trypanosoma brucei alpha tubulin 0.1559 0.7476 0.7474
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0008 0.0008
Brugia malayi Death domain containing protein 0.0015 0.0007 0.0007
Schistosoma mansoni tubulin subunit alpha 0.0535 0.2519 0.2519
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0074 0.0074
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0167 0.0167
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0163 0.0163
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0075 0.0075
Loa Loa (eye worm) tubulin beta chain 0.2081 1 1
Entamoeba histolytica tubulin alpha-1 chain 0.1559 0.7476 0.7319
Loa Loa (eye worm) hypothetical protein 0.0029 0.0075 0.0075
Trichomonas vaginalis set domain proteins, putative 0.0239 0.1092 0.0997
Trichomonas vaginalis tubulin alpha chain, putative 0.0632 0.299 0.2915
Trypanosoma brucei epsilon tubulin 0.1272 0.6087 0.6084
Loa Loa (eye worm) tubulin alpha 2 0.0393 0.1834 0.1834
Echinococcus multilocularis tubulin subunit beta 0.2081 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.1559 0.7476 0.7476
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0167 0.0167
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0075 0.0075
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0007 0.0007
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1559 0.7476 0.7449
Trypanosoma brucei alpha tubulin 0.1559 0.7476 0.7474
Trypanosoma brucei tubulin gamma chain 0.1274 0.6095 0.6092
Echinococcus granulosus death domain containing protein 0.0015 0.0007 0.0007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0075 0.0075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0075 0.0075
Echinococcus multilocularis Tubulin beta 2C chain 0.2081 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.1559 0.7476 0.7476
Schistosoma mansoni hypothetical protein 0.0015 0.0008 0.0008
Leishmania major alpha tubulin 0.1559 0.7476 0.7474
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0075 0.0075
Echinococcus granulosus beta tubulin 0.2081 1 1
Echinococcus granulosus mitogen activated protein kinase 0.0102 0.0428 0.0428
Brugia malayi Tubulin alpha chain 0.1559 0.7476 0.7476
Brugia malayi Cytochrome P450 family protein 0.0025 0.0053 0.0053
Trichomonas vaginalis tubulin gamma chain, putative 0.2081 1 1
Trypanosoma brucei zeta tubulin, putative 0.1643 0.7882 0.788
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0225 0.0225
Giardia lamblia Beta tubulin 0.2081 1 1
Brugia malayi mbt repeat family protein 0.0048 0.0167 0.0167
Trypanosoma brucei epsilon tubulin 0.1272 0.6087 0.6084
Echinococcus multilocularis tubulin alpha chain 0.1559 0.7476 0.7476
Schistosoma mansoni zinc finger protein 0.0015 0.0008 0.0008
Brugia malayi photoreceptor-specific nuclear receptor 0.0029 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0029 0.0075 0.0075
Leishmania major beta tubulin 0.2081 1 1
Loa Loa (eye worm) BEN-1 protein 0.2081 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.1559 0.7476 0.7449
Toxoplasma gondii alpha tubulin TUBA1 0.1559 0.7476 0.7456
Leishmania major alpha tubulin 0.1559 0.7476 0.7474
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0135 0.0586 0.0586
Brugia malayi Tubulin beta chain 0.0632 0.299 0.299
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0428 0.0326
Trypanosoma cruzi epsilon tubulin, putative 0.1272 0.6087 0.6084
Brugia malayi alpha-tubulin 0.1559 0.7476 0.7476
Echinococcus multilocularis hypothetical protein 0.1559 0.7476 0.7476
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0075 0.0075
Giardia lamblia Beta tubulin 0.2081 1 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0135 0.0586 0.0578
Trichomonas vaginalis tubulin beta chain, putative 0.1559 0.7476 0.7449
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0075 0.0075
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0008 0.0008
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0075 0.0075
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0135 0.0586 0.0586
Brugia malayi MAP kinase sur-1 0.0102 0.0428 0.0428
Loa Loa (eye worm) alpha-tubulin isotype 2 0.1025 0.489 0.489
Trichomonas vaginalis tubulin, putative 0.0632 0.299 0.2915
Echinococcus granulosus beta tubulin 0.2081 1 1
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0047 0.0163 0.0163
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0075 0.0075
Trichomonas vaginalis tubulin beta chain, putative 0.1559 0.7476 0.7449
Giardia lamblia Beta tubulin 0.2081 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0075 0.0075
Loa Loa (eye worm) tubulin beta chain 0.0535 0.2519 0.2519
Brugia malayi Tubulin beta chain 0.0535 0.2519 0.2519
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Echinococcus granulosus tubulin alpha 3 chain 0.1559 0.7476 0.7476
Entamoeba histolytica tubulin family protein 0.2081 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.1272 0.6087 0.6046
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0428 0.0326
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0428 0.0326
Giardia lamblia Epsilon tubulin 0.064 0.3031 0.272
Loa Loa (eye worm) hypothetical protein 0.0033 0.0093 0.0093
Echinococcus granulosus muscleblind protein 0.0151 0.0664 0.0664
Brugia malayi PHD-finger family protein 0.0025 0.0055 0.0055
Leishmania major beta tubulin 0.2081 1 1
Brugia malayi Bromodomain containing protein 0.0039 0.0121 0.0121
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0029 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0029 0.0075 0.0075
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0199 0.0199
Giardia lamblia Alpha-tubulin 0.1559 0.7476 0.7363
Echinococcus granulosus tubulin subunit TubB 0.1559 0.7476 0.7476
Trichomonas vaginalis tubulin alpha chain, putative 0.0632 0.299 0.2915
Echinococcus granulosus Tubulin beta 2C chain 0.2081 1 1
Echinococcus granulosus tubulin delta chain 0.0535 0.2519 0.2519
Trypanosoma brucei alpha tubulin, putative 0.0632 0.299 0.2984
Brugia malayi ecdysteroid receptor 0.0029 0.0075 0.0075
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0008 0.0008
Plasmodium vivax tubulin alpha chain, putative 0.1559 0.7476 0.7456
Giardia lamblia Delta tubulin 0.0535 0.2519 0.2185
Loa Loa (eye worm) MBCTL1 0.0055 0.0199 0.0199
Schistosoma mansoni alpha tubulin 0.1559 0.7476 0.7476
Leishmania major beta tubulin 0.2081 1 1
Leishmania major beta tubulin 0.2081 1 1
Mycobacterium tuberculosis Cell division protein FtsZ 0.0535 0.2519 0.5
Brugia malayi Pre-SET motif family protein 0.003 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0927 0.442 0.442
Plasmodium vivax tubulin epsilon chain, putative 0.1272 0.6087 0.6056
Schistosoma mansoni tubulin subunit delta 0.0535 0.2519 0.2519
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0535 0.2519 0.244
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0089 0.0365 0.0365
Leishmania major zeta tubulin, putative 0.1643 0.7882 0.788
Echinococcus granulosus tubulin alpha chain 0.1559 0.7476 0.7476
Echinococcus multilocularis tubulin alpha 1C chain 0.1559 0.7476 0.7476
Trypanosoma brucei zeta tubulin 0.1643 0.7882 0.788
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0075 0.0075
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0199 0.0199
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0075 0.0075
Echinococcus multilocularis Tubulin beta 2C chain 0.2081 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0428 0.0326
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0199 0.0199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0075 0.0075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0075 0.0075
Toxoplasma gondii beta-1 tubulin, putative 0.2081 1 1
Schistosoma mansoni hypothetical protein 0.0072 0.0284 0.0284
Trypanosoma brucei tubulin delta chain 0.1198 0.5727 0.5724
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.1025 0.489 0.4836
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0075 0.0075
Brugia malayi Uncoordinated protein 44 0.0015 0.0007 0.0007
Mycobacterium leprae cell division protein FtsZ 0.0535 0.2519 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0075 0.0075
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0167 0.0167
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0135 0.0586 0.0586
Trichomonas vaginalis tubulin, putative 0.2081 1 1
Brugia malayi Protein kinase domain containing protein 0.0016 0.0012 0.0012
Echinococcus granulosus Tubulin alpha 1 chain 0.1559 0.7476 0.7476
Brugia malayi Tubulin alpha-2 chain 0.1559 0.7476 0.7476
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0007 0.0007
Echinococcus granulosus tubulin alpha 1C chain 0.1559 0.7476 0.7476
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0079 0.0079
Echinococcus granulosus peroxisome assembly protein 26 0.1559 0.7476 0.7476
Echinococcus granulosus tubulin alpha 3 chain 0.1559 0.7476 0.7476
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0075 0.0075
Loa Loa (eye worm) beta-tubulin 0.2081 1 1
Toxoplasma gondii beta-tubulin, putative 0.2081 1 1
Echinococcus multilocularis muscleblind protein 1 0.0151 0.0664 0.0664
Brugia malayi bZIP transcription factor family protein 0.0089 0.0365 0.0365
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0044 0.0044
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0117 0.0117
Leishmania major beta tubulin 0.2081 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.2081 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.1559 0.7476 0.7449
Brugia malayi steroid hormone receptor 0.0029 0.0075 0.0075
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.1166 0.5575 0.554
Echinococcus granulosus tubulin beta 4A class IVa 0.2081 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0535 0.2519 0.244
Echinococcus multilocularis zinc finger protein 0.002 0.0029 0.0029
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0075 0.0075
Trypanosoma brucei beta tubulin 0.2081 1 1
Leishmania major alpha tubulin 0.1559 0.7476 0.7474
Leishmania major beta tubulin 0.2081 1 1
Loa Loa (eye worm) alpha-tubulin 0.1559 0.7476 0.7476
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0167 0.0557
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0167 0.0167
Leishmania major alpha tubulin 0.1559 0.7476 0.7474
Loa Loa (eye worm) tubulin alpha 2 0.1025 0.489 0.489
Loa Loa (eye worm) hypothetical protein 0.0055 0.0199 0.0199
Plasmodium falciparum alpha tubulin 2 0.1559 0.7476 0.6626
Brugia malayi Tubulin alpha chain 0.0535 0.2519 0.2519
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.0951 0.0951
Echinococcus multilocularis tubulin beta 1 chain 0.2081 1 1
Schistosoma mansoni coup transcription factor 0.0029 0.0075 0.0075
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0075 0.0075
Loa Loa (eye worm) tubulin beta-2A chain 0.2081 1 1
Plasmodium vivax tubulin alpha chain, putative 0.1559 0.7476 0.7456
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0167 0.0167
Brugia malayi tubulin alpha chain - mouse 0.1559 0.7476 0.7476
Leishmania major alpha tubulin 0.1559 0.7476 0.7474
Trichomonas vaginalis tubulin gamma chain, putative 0.1274 0.6095 0.6053
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0535 0.2519 0.5
Echinococcus granulosus zinc finger protein 0.002 0.0029 0.0029
Echinococcus granulosus Tubulin beta 2C chain 0.2081 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.2081 1 1
Leishmania major gamma-tubulin 0.1274 0.6095 0.6092
Schistosoma mansoni hypothetical protein 0.0021 0.0034 0.0034
Trichomonas vaginalis tubulin epsilon chain, putative 0.2081 1 1
Leishmania major beta tubulin 0.2081 1 1
Echinococcus multilocularis tubulin alpha 3 chain 0.1559 0.7476 0.7476
Loa Loa (eye worm) hypothetical protein 0.1559 0.7476 0.7476
Echinococcus multilocularis tubulin alpha 1C chain 0.1559 0.7476 0.7476
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0034 0.0034
Brugia malayi nuclear hormone receptor 0.0029 0.0075 0.0075
Leishmania major alpha tubulin 0.1559 0.7476 0.7474
Trichomonas vaginalis tubulin alpha chain, putative 0.0632 0.299 0.2915
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0075 0.0075
Trichomonas vaginalis tubulin beta chain, putative 0.1559 0.7476 0.7449
Echinococcus multilocularis mitogen activated protein kinase 3 0.0102 0.0428 0.0428
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0163 0.0163
Leishmania major beta tubulin 0.2081 1 1
Brugia malayi hypothetical protein 0.0015 0.0008 0.0008
Echinococcus multilocularis peroxisome assembly protein 26 0.1559 0.7476 0.7476
Leishmania major beta tubulin 0.2081 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0075 0.0075
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0102 0.0428 0.042
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0078 0.0312 0.0312
Trypanosoma cruzi tubulin delta chain 0.1198 0.5727 0.5724
Giardia lamblia Gamma tubulin 0.1274 0.6095 0.592
Trypanosoma cruzi epsilon tubulin, putative 0.1272 0.6087 0.6084
Schistosoma mansoni jun-related protein 0.0072 0.0284 0.0284
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0053 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0075 0.0075
Echinococcus granulosus tubulin alpha 0.1166 0.5575 0.5575
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0117 0.0117
Echinococcus multilocularis Tubulin beta 2C chain 0.2081 1 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0048 0.0167 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0075 0.0075
Trypanosoma brucei protein kinase, putative 0.0102 0.0428 0.042
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0167 0.0167
Trichomonas vaginalis tubulin epsilon chain, putative 0.2081 1 1
Schistosoma mansoni bromodomain containing protein 0.0064 0.0243 0.0243
Trichomonas vaginalis tubulin beta chain, putative 0.2081 1 1
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0075 0.0075
Plasmodium falciparum alpha tubulin 1 0.1559 0.7476 0.6626
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0075 0.0075
Onchocerca volvulus 0.0632 0.299 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0075 0.0075
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0134 0.0134
Echinococcus multilocularis tubulin alpha chain 0.1559 0.7476 0.7476
Echinococcus multilocularis mitogen activated protein kinase 0.0102 0.0428 0.0428
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0029 0.0075 0.0075
Brugia malayi hypothetical protein 0.007 0.0272 0.0272
Echinococcus granulosus tubulin alpha chain 0.1559 0.7476 0.7476
Loa Loa (eye worm) tubulin beta-4 chain 0.2081 1 1
Echinococcus granulosus Ankyrin 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0018 0.0018
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0199 0.0199
Toxoplasma gondii beta tubulin 0.2081 1 1
Schistosoma mansoni tubulin subunit alpha 0.1559 0.7476 0.7476
Plasmodium vivax delta tubulin, putative 0.0535 0.2519 0.2459
Schistosoma mansoni tubulin subunit beta 0.2081 1 1
Plasmodium vivax tubulin beta chain, putative 0.2081 1 1
Trichomonas vaginalis tubulin, putative 0.0632 0.299 0.2915
Echinococcus granulosus alpha tubulin 0.1559 0.7476 0.7476
Echinococcus multilocularis Tubulin beta 2C chain 0.2081 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0117 0.0117
Schistosoma mansoni tubulin subunit beta 0.2081 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.1559 0.7476 0.7476
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0163 0.0163
Echinococcus granulosus Tubulin alpha 1 chain 0.1559 0.7476 0.7476
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0075 0.0075
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0102 0.0428 0.042
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.064 0.3031 0.2975
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.1198 0.5727 0.5693
Trypanosoma cruzi tubulin gamma chain 0.1274 0.6095 0.6092
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0075 0.0075
Echinococcus multilocularis beta tubulin 0.2081 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0075 0.025
Brugia malayi nuclear receptor NHR-88 0.0029 0.0075 0.0075
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.0586 0.0578
Trichomonas vaginalis tubulin epsilon chain, putative 0.1559 0.7476 0.7449
Loa Loa (eye worm) hypothetical protein 0.0151 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0075 0.0075
Echinococcus granulosus nuclear factor of activated T cells 5 0.0078 0.0312 0.0312
Schistosoma mansoni tubulin subunit beta 0.2081 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.2081 1 1
Leishmania major alpha tubulin 0.1559 0.7476 0.7474
Loa Loa (eye worm) tubulin beta-1 chain 0.2081 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0428 0.0428
Trichomonas vaginalis tubulin beta chain, putative 0.0632 0.299 0.2915
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0075 0.0075
Onchocerca volvulus 0.0048 0.0167 0.0557
Schistosoma mansoni alpha tubulin 0.1559 0.7476 0.7476
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0075 0.025
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0535 0.2519 0.244
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0053 0.0045
Schistosoma mansoni netrin receptor unc5 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0041 0.0133 0.0133
Leishmania major beta tubulin 0.2081 1 1
Trypanosoma brucei alpha tubulin 0.1559 0.7476 0.7474
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0079 0.0079
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0075 0.0075
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0199 0.0199
Onchocerca volvulus 0.024 0.1092 0.3654
Plasmodium falciparum tubulin epsilon chain, putative 0.1272 0.6087 0.477
Loa Loa (eye worm) tubulin alpha 2 0.1025 0.489 0.489
Loa Loa (eye worm) alpha-tubulin 0.1559 0.7476 0.7476
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0007 0.0007
Loa Loa (eye worm) tubulin alpha-3 chain 0.0927 0.442 0.442
Echinococcus multilocularis tubulin alpha chain 0.1559 0.7476 0.7476
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0087 0.0353 0.0353
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0135 0.0586 0.0586
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0102 0.0428 0.042
Echinococcus granulosus tubulin epsilon chain 0.1272 0.6087 0.6087
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0075 0.0075
Leishmania major alpha tubulin 0.1559 0.7476 0.7474
Trichomonas vaginalis tubulin beta chain, putative 0.1559 0.7476 0.7449
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0029 0.0075 0.0075
Brugia malayi follicle stimulating hormone receptor 0.0239 0.1089 0.1089
Onchocerca volvulus 0.003 0.0079 0.0265
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0075 0.0075
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0075 0.0075
Schistosoma mansoni tubulin subunit gamma 0.1274 0.6095 0.6095
Trichomonas vaginalis tubulin alpha chain, putative 0.1166 0.5575 0.5528
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0017 0.0017
Brugia malayi beta-tubulin, identical 0.2081 1 1
Schistosoma mansoni tubulin subunit alpha 0.1559 0.7476 0.7476
Loa Loa (eye worm) tubulin alpha chain 0.1559 0.7476 0.7476
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0044 0.0044
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0075 0.0075
Leishmania major beta tubulin 0.2081 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0008 0.0008
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0008 0.0008
Echinococcus multilocularis tubulin epsilon chain 0.1272 0.6087 0.6087
Schistosoma mansoni hypothetical protein 0.0293 0.1352 0.1352
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0072 0.0279 0.0279
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0075 0.0075
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0075 0.0075
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0102 0.0428 0.0428
Plasmodium vivax tubulin gamma chain, putative 0.1274 0.6095 0.6064
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0007 0.0007
Leishmania major beta tubulin 0.2081 1 1
Brugia malayi Pre-SET motif family protein 0.021 0.0951 0.0951
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Trypanosoma cruzi zeta tubulin, putative 0.1643 0.7882 0.788
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.002 0.002
Echinococcus granulosus Tubulin beta 2C chain 0.2081 1 1
Schistosoma mansoni tubulin subunit beta 0.0535 0.2519 0.2519
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0075 0.0075
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0044 0.0044
Brugia malayi Cytochrome P450 family protein 0.0025 0.0053 0.0053
Echinococcus multilocularis tubulin gamma 1 chain 0.1274 0.6095 0.6095
Leishmania major beta tubulin 0.2081 1 1
Trypanosoma cruzi alpha tubulin, putative 0.1559 0.7476 0.7474
Echinococcus granulosus tubulin alpha 1C chain 0.1559 0.7476 0.7476
Echinococcus granulosus tubulin alpha chain 0.1559 0.7476 0.7476
Loa Loa (eye worm) tubulin alpha chain 0.1559 0.7476 0.7476
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0102 0.0428 0.042
Loa Loa (eye worm) hypothetical protein 0.0151 0.0664 0.0664
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0117 0.0117
Trypanosoma brucei beta tubulin 0.1166 0.5575 0.5572
Echinococcus multilocularis muscleblind protein 0.0151 0.0664 0.0664
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0102 0.0428 0.042
Brugia malayi mbt repeat family protein 0.0048 0.0167 0.0167
Echinococcus multilocularis tubulin subunit TubB 0.1559 0.7476 0.7476
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0199 0.0199
Entamoeba histolytica tubulin gamma chain 0.1274 0.6095 0.5852
Mycobacterium ulcerans cell division protein FtsZ 0.0535 0.2519 1
Brugia malayi Cell division protein ftsZ 0.0535 0.2519 0.2519
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.0015 0.0007 0.0007
Schistosoma mansoni tubulin subunit alpha 0.1559 0.7476 0.7476
Echinococcus granulosus jun protein 0.0089 0.0365 0.0365
Plasmodium falciparum tubulin beta chain 0.2081 1 1
Echinococcus multilocularis Ankyrin 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.1025 0.489 0.489
Echinococcus granulosus tubulin gamma 1 chain 0.1274 0.6095 0.6095
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0075 0.0075
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0053 0.0053
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0089 0.0365 0.0365
Echinococcus granulosus tubulin beta 1 chain 0.2081 1 1
Entamoeba histolytica tubulin alpha chain, putative 0.1559 0.7476 0.7319
Leishmania major beta tubulin 0.2081 1 1
Leishmania major beta tubulin 0.2081 1 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.0586 0.0578
Echinococcus multilocularis tubulin, beta 4A class IVa 0.2081 1 1
Onchocerca volvulus 0.007 0.0272 0.091
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0632 0.299 0.2915
Trypanosoma cruzi tubulin delta chain 0.1198 0.5727 0.5724
Leishmania major beta tubulin 0.2081 1 1
Schistosoma mansoni tubulin subunit beta 0.2081 1 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0017 0.0017
Trichomonas vaginalis tubulin, putative 0.0642 0.3039 0.2964
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0075 0.0075
Loa Loa (eye worm) tubulin gamma chain 0.1274 0.6095 0.6095
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0075 0.0075
Echinococcus multilocularis tubulin alpha 0.1166 0.5575 0.5575
Schistosoma mansoni tubulin subunit beta 0.2081 1 1
Echinococcus multilocularis tubulin delta chain 0.0535 0.2519 0.2519
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0927 0.442 0.436
Entamoeba histolytica tubulin family protein 0.2081 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0053 0.0053
Brugia malayi nuclear receptor RXR 0.0015 0.0008 0.0008
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0102 0.0428 0.042
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0008 0.0008
Leishmania major epsilon tubulin, putative 0.1272 0.6087 0.6084
Trypanosoma cruzi beta tubulin, putative 0.2081 1 1
Trypanosoma brucei alpha tubulin 0.1559 0.7476 0.7474
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0053 0.0045
Trypanosoma brucei epsilon tubulin 0.1166 0.5575 0.5572
Schistosoma mansoni zinc finger protein 0.002 0.0029 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0535 0.2519 0.244
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0135 0.0586 0.0586
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0017 0.0017
Echinococcus multilocularis tubulin alpha chain 0.1559 0.7476 0.7476
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0008 0.0008
Echinococcus granulosus tubulin alpha chain 0.1559 0.7476 0.7476
Echinococcus multilocularis thyroid hormone receptor alpha 0.0029 0.0075 0.0075
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.0586 0.0578
Echinococcus granulosus mitogen activated protein kinase 3 0.0102 0.0428 0.0428
Toxoplasma gondii tubulin, putative 0.0106 0.0445 0.0369
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0075 0.0075
Schistosoma mansoni tubulin subunit beta 0.2081 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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