TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 497.583 | Formula: C34H27NO3
H donors: 0 H acceptors: 1 LogP: 7.54 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=c1c2ccccc2n(c2c1cccc2)Cc1cc(OCc2ccccc2)cc(c1)OCc1ccccc1
InChi: 1S/C34H27NO3/c36-34-30-15-7-9-17-32(30)35(33-18-10-8-16-31(33)34)22-27-19-28(37-23-25-11-3-1-4-12-25)21-29(20-27)38-24-26-13-5-2-6-14-26/h1-21H,22-24H2
InChiKey: WKKATJBENFZAOT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tyrosine protein kinase csk	0.0056	0.0039	0.004
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Schistosoma mansoni	dynamin	0.0069	0.0068	0.0054
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0068	0.0439
Echinococcus multilocularis	regulator of G protein signaling 7	0.075	0.1553	0.1851
Brugia malayi	Variant SH3 domain containing protein	0.0069	0.0068	0.0062
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0069	0.0068	0.019
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0069	0.0068	0.0075
Echinococcus multilocularis	roundabout 2	0.0117	0.0174	0.0201
Brugia malayi	hypothetical protein	0.0117	0.0174	0.0168
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0056	0.0039	0.004
Toxoplasma gondii	aurora kinase	0.0078	0.0089	0.7179
Schistosoma mansoni	regulator of G protein signaling	0.075	0.1553	0.1541
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0039	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0174	0.0168
Loa Loa (eye worm)	TK protein kinase	0.0056	0.0039	0.0034
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Toxoplasma gondii	hypothetical protein	0.0069	0.0068	0.4164
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0056	0.0039	0.004
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0069	0.0068	0.0164
Loa Loa (eye worm)	PXA domain-containing protein	0.075	0.1553	0.1548
Entamoeba histolytica	protein kinase, putative	0.0087	0.0109	0.0457
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0078	0.0089	0.7179
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0056	0.0039	0.0026
Echinococcus multilocularis	tyrosine protein kinase	0.0056	0.0039	0.004
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0078	0.0089	0.0328
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0087	0.0109	1
Echinococcus granulosus	pdz domain containing protein	0.0069	0.0068	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0163	0.0157
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0056	0.0039	0.004
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0056	0.0039	0.004
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0056	0.0039	0.004
Schistosoma mansoni	regulator of G protein signaling	0.075	0.1553	0.1541
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0039	0.0034
Schistosoma mansoni	regulator of G protein signaling	0.075	0.1553	0.1541
Brugia malayi	PH domain containing protein	0.0069	0.0068	0.0062
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Schistosoma mansoni	serine/threonine protein kinase	0.0056	0.0039	0.0026
Echinococcus granulosus	exocyst complex component 2	0.016	0.0268	0.0313
Brugia malayi	SH2 domain containing protein	0.0056	0.0039	0.0034
Brugia malayi	PH domain containing protein	0.0069	0.0068	0.0062
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Trypanosoma cruzi	NIMA-related kinase, putative	0.0087	0.0109	1
Loa Loa (eye worm)	AUR protein kinase	0.0078	0.0089	0.0083
Trichomonas vaginalis	conserved hypothetical protein	0.075	0.1553	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0056	0.0039	0.004
Echinococcus granulosus	receptor type guanylyl cyclase	0.0056	0.0039	0.004
Loa Loa (eye worm)	TK protein kinase	0.0056	0.0039	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0039	0.0034
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0069	0.0068	0.0062
Echinococcus multilocularis	integrin linked protein kinase	0.0056	0.0039	0.004
Echinococcus multilocularis	rac serine:threonine kinase	0.0087	0.0109	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0211	0.0378	0.0372
Entamoeba histolytica	protein kinase, putative	0.0087	0.0109	0.0457
Brugia malayi	Plekhf2 protein	0.0069	0.0068	0.0062
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0056	0.0039	0.004
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0039	0.0034
Entamoeba histolytica	hypothetical protein	0.016	0.0268	0.1508
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0039	0.0034
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0087	0.0109	1
Trichomonas vaginalis	CAMK family protein kinase	0.0056	0.0039	0.0254
Brugia malayi	Tyrosine-protein kinase abl-1	0.0056	0.0039	0.0034
Brugia malayi	Plexin repeat family protein	0.0863	0.1797	0.1792
Brugia malayi	ephrin receptor 1 precursor	0.0056	0.0039	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0068	0.0062
Entamoeba histolytica	hypothetical protein	0.075	0.1553	1
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0039	0.0254
Echinococcus granulosus	tyrosine kinase	0.0056	0.0039	0.004
Schistosoma mansoni	protein tyrosine kinase	0.0056	0.0039	0.0026
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0069	0.0068	0.4164
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0056	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Echinococcus granulosus	neuroglian	0.0112	0.0163	0.0188
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0069	0.0068	0.0062
Trypanosoma brucei	aurora B kinase	0.0078	0.0089	0.7179
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0069	0.0068	0.019
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0068	0.0062
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Echinococcus granulosus	epidermal growth factor receptor	0.0056	0.0039	0.004
Echinococcus multilocularis	Pleckstrin y	0.0069	0.0068	0.0075
Loa Loa (eye worm)	TK/Met protein kinase	0.0056	0.0039	0.0034
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0069	0.0068	0.019
Entamoeba histolytica	hypothetical protein	0.0087	0.0109	0.0457
Trichomonas vaginalis	centaurin/arf, putative	0.0069	0.0068	0.0439
Trypanosoma cruzi	hypothetical protein	0.0069	0.0068	0.4164
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0069	0.0068	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0068	0.0062
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0061	0.005	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0039	0.0034
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0069	0.0068	0.0062
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0069	0.0068	0.0075
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.016	0.0268	0.1723
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0069	0.0068	0.0075
Echinococcus granulosus	protein kinase	0.0056	0.0039	0.004
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0039	0.0034
Schistosoma mansoni	serine/threonine protein kinase	0.3547	0.7646	0.7643
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0056	0.0039	0.0254
Echinococcus granulosus	dynamin 1	0.0069	0.0068	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Echinococcus multilocularis	aurora kinase A	0.0078	0.0089	0.01
Schistosoma mansoni	vesicular amine transporter	0.0115	0.0169	0.0155
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0056	0.0039	0.004
Trichomonas vaginalis	TK family protein kinase	0.0056	0.0039	0.0254
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0056	0.0039	0.0254
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0056	0.0039	0.004
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0056	0.0039	0.004
Echinococcus granulosus	myotubularin protein 13	0.0069	0.0068	0.0075
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Echinococcus granulosus	semaphorin 5B	0.0366	0.0716	0.0849
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0056	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0068	0.0439
Echinococcus multilocularis	tyrosine protein kinase shark	0.0056	0.0039	0.004
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0069	0.0068	0.0439
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0068	0.0439
Entamoeba histolytica	hypothetical protein	0.0069	0.0068	0.019
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Echinococcus multilocularis	epidermal growth factor receptor	0.0056	0.0039	0.004
Onchocerca volvulus	outspread protein homolog	0.0069	0.0068	0.0164
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0056	0.0039	0.0034
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0056	0.0039	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0163	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0163	0.0157
Echinococcus granulosus	pleckstrin y domain containing family A	0.0069	0.0068	0.0075
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0056	0.0039	0.0034
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0074	0.008	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0039	0.0034
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0056	0.0039	0.004
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.075	0.1553	1
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Schistosoma mansoni	hypothetical protein	0.0366	0.0716	0.0703
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0039	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0068	0.0062
Echinococcus multilocularis	exocyst complex component 2	0.016	0.0268	0.0313
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0056	0.0039	0.004
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0056	0.0039	0.0026
Brugia malayi	Receptor family ligand binding region containing protein	0.0056	0.0039	0.0034
Brugia malayi	Oxysterol-binding protein	0.0069	0.0068	0.0062
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0069	0.0068	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0069	0.0068	0.0075
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Loa Loa (eye worm)	TK/EPH protein kinase	0.0056	0.0039	0.0034
Schistosoma mansoni	serine/threonine-protein kinase	0.0087	0.0109	0.0095
Echinococcus multilocularis	oxysterol binding protein 3	0.0069	0.0068	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0068	0.0062
Brugia malayi	serine/threonine-protein kinase 6	0.0078	0.0089	0.0083
Loa Loa (eye worm)	hypothetical protein	0.016	0.0268	0.0262
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0069	0.0068	0.0075
Echinococcus multilocularis	axis inhibition protein axin	0.075	0.1553	0.1851
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0039	0.0254
Echinococcus granulosus	calcium dependent secretion activator 1	0.0069	0.0068	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0112	0.0163	0.0149
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0112	0.0163	0.0188
Echinococcus multilocularis	dynamin 1	0.0069	0.0068	0.0075
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0039	0.0034
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Loa Loa (eye worm)	uncoordinated protein 104	0.0069	0.0068	0.0062
Leishmania major	folate/biopterin transporter, putative	0.0087	0.0109	1
Loa Loa (eye worm)	oxysterol binding protein	0.0069	0.0068	0.0062
Entamoeba histolytica	protein kinase, putative	0.0087	0.0109	0.0457
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0069	0.0068	0.0075
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0039	0.0034
Brugia malayi	Raf kinase	0.0056	0.0039	0.0034
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0056	0.0039	0.0034
Schistosoma mansoni	protein kinase	0.0074	0.008	0.0066
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0069	0.0068	0.0075
Echinococcus granulosus	tyrosine protein kinase csk	0.0056	0.0039	0.004
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0039	0.0034
Schistosoma mansoni	serine/threonine protein kinase	0.0056	0.0039	0.0026
Entamoeba histolytica	hypothetical protein, conserved	0.0069	0.0068	0.019
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0112	0.0163	0.0149
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0069	0.0068	0.0075
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Echinococcus granulosus	integrin linked protein kinase	0.0056	0.0039	0.004
Brugia malayi	PH domain containing protein	0.0069	0.0068	0.0062
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0056	0.0039	0.0034
Brugia malayi	PH domain containing protein	0.0069	0.0068	0.0062
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0069	0.0068	0.0062
Toxoplasma gondii	protein kinase domain-containing protein	0.0087	0.0109	1
Toxoplasma gondii	AtPH1 family protein	0.0069	0.0068	0.4164
Brugia malayi	MAX-1A	0.0069	0.0068	0.0062
Loa Loa (eye worm)	PH domain-containing protein	0.0069	0.0068	0.0062
Giardia lamblia	Aurora kinase	0.0078	0.0089	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0068	0.0062
Schistosoma mansoni	hypothetical protein	0.016	0.0268	0.0254
Echinococcus granulosus	tyrosine protein kinase csk	0.0056	0.0039	0.004
Schistosoma mansoni	hypothetical protein	0.0366	0.0716	0.0703
Brugia malayi	hypothetical protein	0.075	0.1553	0.1548
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0087	0.0109	1
Loa Loa (eye worm)	hypothetical protein	0.016	0.0268	0.0262
Echinococcus granulosus	expressed protein	0.075	0.1553	0.1851
Echinococcus multilocularis	c src tyrosine kinase	0.0056	0.0039	0.004
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0056	0.0039	0.004
Loa Loa (eye worm)	AUR protein kinase	0.0078	0.0089	0.0083
Schistosoma mansoni	zinc finger protein	0.0069	0.0068	0.0054
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0056	0.0039	0.004
Echinococcus multilocularis	FL cytokine receptor	0.0056	0.0039	0.004
Brugia malayi	Probable exocyst complex component Sec5	0.016	0.0268	0.0262
Trichomonas vaginalis	centaurin gamma, putative	0.0069	0.0068	0.0439
Brugia malayi	Regulator of G protein signaling domain containing protein	0.075	0.1553	0.1548
Loa Loa (eye worm)	hypothetical protein	0.075	0.1553	0.1548
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0087	0.0109	1
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0056	0.0039	0.0034
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0069	0.0068	0.019
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0069	0.0068	0.4164
Entamoeba histolytica	hypothetical protein	0.075	0.1553	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0056	0.0039	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0068	0.0062
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0068	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0366	0.0716	0.071
Brugia malayi	Syntrophin-1	0.0069	0.0068	0.0062
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0069	0.0068	0.019
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0074	0.008	0.5836
Entamoeba histolytica	protein kinase, putative	0.0087	0.0109	0.0457
Schistosoma mansoni	protein kinase	0.0074	0.008	0.0066
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Trichomonas vaginalis	kinesin light chain, putative	0.0069	0.0068	0.0439
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0068	0.0439
Echinococcus multilocularis	protein kinase	0.0056	0.0039	0.004
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Loa Loa (eye worm)	hypothetical protein	0.0366	0.0716	0.071
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0069	0.0068	0.4164
Trypanosoma brucei	protein kinase, putative	0.0087	0.0109	1
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0069	0.0068	0.0075
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0039	0.0034
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0056	0.0039	0.004
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0056	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Brugia malayi	Cytohesin 3	0.0069	0.0068	0.0062
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0056	0.0039	0.0034
Onchocerca volvulus		0.0863	0.1797	1
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0069	0.0068	0.4164
Echinococcus multilocularis	beta 1 syntrophin	0.0069	0.0068	0.0075
Onchocerca volvulus		0.0069	0.0068	0.0164
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0068	0.0439
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0039	0.0034
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0069	0.0068	0.019
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Echinococcus multilocularis	tyrosine protein kinase csk	0.0056	0.0039	0.004
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0056	0.0039	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0068	0.0062
Echinococcus granulosus	tyrosine protein kinase Srms	0.0056	0.0039	0.004
Echinococcus granulosus	epidermal growth factor receptor	0.0056	0.0039	0.004
Schistosoma mansoni	vav2	0.0069	0.0068	0.0054
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Schistosoma mansoni	centaurin alpha	0.0069	0.0068	0.0054
Brugia malayi	probable spectrin beta chain	0.0069	0.0068	0.0062
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0087	0.0109	1
Echinococcus granulosus	beta 1 syntrophin	0.0069	0.0068	0.0075
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Loa Loa (eye worm)	SRC-1	0.0056	0.0039	0.0034
Echinococcus granulosus	serine/threonine protein kinase	0.0087	0.0109	0.0123
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0087	0.0109	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0056	0.0039	0.004
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0087	0.0109	1
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0069	0.0068	0.0075
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0087	0.0109	0.0457
Echinococcus granulosus	ephrin type A receptor 4 A	0.0056	0.0039	0.004
Echinococcus multilocularis	semaphorin 5B	0.0366	0.0716	0.0849
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Schistosoma mansoni	plexin	0.0863	0.1797	0.1786
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Echinococcus multilocularis	pdz domain containing protein	0.0069	0.0068	0.0075
Brugia malayi	PH domain containing protein	0.0069	0.0068	0.0062
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Echinococcus granulosus	oxysterol binding protein 3	0.0069	0.0068	0.0075
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0069	0.0068	0.0054
Echinococcus granulosus	regulator of G protein signaling 7	0.075	0.1553	0.1851
Echinococcus granulosus	twitchin	0.0131	0.0203	0.0236
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0087	0.0109	1
Echinococcus multilocularis	tyrosine kinase	0.0056	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0068	0.0439
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Loa Loa (eye worm)	TK/INSR protein kinase	0.0056	0.0039	0.0034
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0056	0.0039	0.004
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Trypanosoma brucei	protein kinase, putative	0.0074	0.008	0.5836
Entamoeba histolytica	tyrosin kinase, putative	0.0216	0.0389	0.2308
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Brugia malayi	protein-tyrosine kinase	0.0056	0.0039	0.0034
Echinococcus granulosus	GRB2 associated binding protein 3	0.0069	0.0068	0.0075
Schistosoma mansoni	hypothetical protein	0.0069	0.0068	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0068	0.0062
Trichomonas vaginalis	centaurin/arf, putative	0.0069	0.0068	0.0439
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.016	0.0268	0.1723
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Trypanosoma cruzi	PH domain containing protein, putative	0.0069	0.0068	0.4164
Schistosoma mansoni	protein kinase	0.0056	0.0039	0.0026
Echinococcus multilocularis	regulator of G protein signaling 3	0.075	0.1553	0.1851
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Echinococcus multilocularis	tyrosine protein kinase csk	0.0056	0.0039	0.004
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0366	0.0716	0.071
Echinococcus multilocularis	cytohesin 1	0.0069	0.0068	0.0075
Schistosoma mansoni	growth factor receptor-bound protein	0.0069	0.0068	0.0054
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0056	0.0039	0.0026
Echinococcus granulosus	aurora kinase A	0.0078	0.0089	0.01
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0056	0.0039	0.004
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0039	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0068	0.0062
Entamoeba histolytica	protein kinase, putative	0.0087	0.0109	0.0457
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0039	0.0034
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0056	0.0039	0.0034
Brugia malayi	PXA domain containing protein	0.075	0.1553	0.1548
Loa Loa (eye worm)	TK protein kinase	0.0056	0.0039	0.0034
Echinococcus multilocularis	neuroglian	0.0112	0.0163	0.0188
Leishmania major	serine/threonine-protein kinase a, putative	0.0087	0.0109	1
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.0268	0.1723
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0061	0.005	0.0053
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0069	0.0068	0.0439
Entamoeba histolytica	hypothetical protein	0.016	0.0268	0.1508
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0087	0.0109	1
Trypanosoma cruzi	aurora B kinase, putative	0.0078	0.0089	0.7179
Trypanosoma cruzi	hypothetical protein	0.0069	0.0068	0.4164
Echinococcus granulosus	tyrosine protein kinase shark	0.0056	0.0039	0.004
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.0268	0.1723
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Echinococcus granulosus	tyrosine protein kinase Blk	0.0056	0.0039	0.004
Loa Loa (eye worm)	TK/ALK protein kinase	0.0295	0.0562	0.0556
Entamoeba histolytica	protein kinase, putative	0.0078	0.0089	0.0328
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.0268	0.1723
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0069	0.0068	0.4164
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.3547	0.7646	0.7645
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Brugia malayi	hypothetical protein	0.0069	0.0068	0.0062
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0069	0.0068	0.0075
Echinococcus granulosus	axis inhibition protein axin	0.075	0.1553	0.1851
Echinococcus granulosus	Pleckstrin y	0.0069	0.0068	0.0075
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0039	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0174	0.0168
Trypanosoma brucei	PH domain containing protein, putative	0.0069	0.0068	0.4164
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Brugia malayi	TBC domain containing protein	0.0069	0.0068	0.0062
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Schistosoma mansoni	hypothetical protein	0.0069	0.0068	0.0054
Brugia malayi	PH domain containing protein	0.0069	0.0068	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0068	0.0062
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0069	0.0068	0.0075
Brugia malayi	hypothetical protein	0.0366	0.0716	0.071
Entamoeba histolytica	p21-activated kinase	0.0087	0.0109	0.0457
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Brugia malayi	Oxysterol binding protein	0.0069	0.0068	0.0062
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0056	0.0039	0.0026
Trichomonas vaginalis	hypothetical protein	0.0069	0.0068	0.0439
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0056	0.0039	0.004
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0056	0.0039	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0068	0.0062
Echinococcus multilocularis	hypothetical protein	0.0366	0.0716	0.0849
Entamoeba histolytica	hypothetical protein	0.0087	0.0109	0.0457
Onchocerca volvulus	Putative zinc finger protein	0.0069	0.0068	0.0164
Echinococcus granulosus	tyrosine kinase	0.0056	0.0039	0.004
Trichomonas vaginalis	protein transport protein sec7, putative	0.0069	0.0068	0.0439
Schistosoma mansoni	goodpasture antigen-binding protein	0.0069	0.0068	0.0054
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0039	0.0034
Schistosoma mansoni	goodpasture antigen-binding protein	0.0069	0.0068	0.0054
Schistosoma mansoni	syntrophin	0.0069	0.0068	0.0054
Loa Loa (eye worm)	TK protein kinase	0.0056	0.0039	0.0034
Brugia malayi	Furin-like cysteine rich region family protein	0.0056	0.0039	0.0034
Schistosoma mansoni	dynamin	0.0069	0.0068	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0366	0.0716	0.071
Toxoplasma gondii	hypothetical protein	0.0069	0.0068	0.4164
Echinococcus granulosus	Regulator of G protein signaling 20	0.075	0.1553	0.1851
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0089	0.0574
Brugia malayi	Protein kinase domain containing protein	0.0087	0.0109	0.0103
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.3878	0.8365	0.8364
Echinococcus multilocularis	Regulator of G protein signaling 20	0.075	0.1553	0.1851
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0087	0.0109	1
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0068	0.0439
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0078	0.0089	0.7179
Echinococcus granulosus	axis inhibition protein axin	0.075	0.1553	0.1851
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0078	0.0089	0.0328
Brugia malayi	PXA domain containing protein	0.075	0.1553	0.1548
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Onchocerca volvulus		0.0366	0.0716	0.3847
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0069	0.0068	0.4164
Leishmania major	hypothetical protein, conserved	0.0069	0.0068	0.4164
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0056	0.0039	0.0026
Echinococcus multilocularis	protein kinase	0.0056	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.0268	0.1723
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0069	0.0068	0.0075
Echinococcus granulosus	activated cdc42 kinase 1	0.0056	0.0039	0.004
Loa Loa (eye worm)	hypothetical protein	0.075	0.1553	0.1548
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.075	0.1553	0.1851
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0056	0.0039	0.004
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Schistosoma mansoni	fibrocystin l	0.016	0.0268	0.0254
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Echinococcus multilocularis	tyrosine kinase	0.0056	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0039	0.0034
Echinococcus granulosus	oxysterol binding protein 9	0.0069	0.0068	0.0075
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0056	0.0039	0.004
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Echinococcus multilocularis	Immunoglobulin	0.0112	0.0163	0.0188
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0056	0.0039	0.0034
Loa Loa (eye worm)	hypothetical protein	0.075	0.1553	0.1548
Schistosoma mansoni	hypothetical protein	0.0069	0.0068	0.0054
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0069	0.0068	0.019
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.016	0.0268	0.1723
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0056	0.0039	0.004
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0056	0.0039	0.004
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0056	0.0039	0.004
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0056	0.0039	0.004
Trichomonas vaginalis	STE family protein kinase	0.0056	0.0039	0.0254
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0087	0.0109	0.0699
Schistosoma mansoni	serine/threonine-protein kinase	0.0087	0.0109	0.0095
Brugia malayi	regulator of G-protein signaling rgs-7	0.075	0.1553	0.1548
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0056	0.0039	0.0034
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0074	0.008	0.5836
Trypanosoma cruzi	PH domain containing protein, putative	0.0069	0.0068	0.4164
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0074	0.008	0.0089
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0056	0.0039	0.004
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0056	0.0039	0.004
Echinococcus granulosus	kinase suppressor of Ras 1	0.0056	0.0039	0.004
Echinococcus granulosus	DCC interacting protein 13 beta	0.0069	0.0068	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0366	0.0716	0.071
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0087	0.0109	1
Schistosoma mansoni	ephrin receptor	0.0061	0.005	0.0036
Echinococcus granulosus	tyrosine protein kinase HCK	0.0056	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0068	0.0439
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0056	0.0039	0.004
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.3878	0.8365	0.8364
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0056	0.0039	0.004
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0068	0.0062
Entamoeba histolytica	PH domain containing protein	0.0069	0.0068	0.019
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0056	0.0039	0.0034
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0056	0.0039	0.004
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0056	0.0039	0.004
Brugia malayi	PH domain containing protein	0.0069	0.0068	0.0062
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Brugia malayi	Uncoordinated protein 104	0.0069	0.0068	0.0062
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Schistosoma mansoni	serine/threonine protein kinase	0.0078	0.0089	0.0075
Loa Loa (eye worm)	TK protein kinase	0.0056	0.0039	0.0034
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.075	0.1553	0.1851
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0056	0.0039	0.004
Brugia malayi	regulator of G-protein signaling egl-10	0.075	0.1553	0.1548
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0056	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Echinococcus multilocularis	actin binding protein anillin	0.0069	0.0068	0.0075
Schistosoma mansoni	myotubularin-related protein	0.0069	0.0068	0.0054
Loa Loa (eye worm)	syntrophin-1	0.0069	0.0068	0.0062
Brugia malayi	Sema domain containing protein	0.0366	0.0716	0.071
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0112	0.0163	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0068	0.0062
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0087	0.0109	0.0457
Echinococcus multilocularis	oxysterol binding protein 9	0.0069	0.0068	0.0075
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0069	0.0068	0.0075
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Schistosoma mansoni	protein kinase	0.0056	0.0039	0.0026
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0056	0.0039	0.004
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0056	0.0039	0.004
Trypanosoma cruzi	Protein kinase B	0.0087	0.0109	1
Brugia malayi	Fibronectin type III domain containing protein	0.0117	0.0174	0.0168
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0087	0.0109	0.0457
Echinococcus granulosus	Rho GTPase activating protein 24	0.0069	0.0068	0.0075
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0056	0.0039	0.004
Plasmodium falciparum	PH domain-containing protein, putative	0.0069	0.0068	0.4164
Brugia malayi	PH domain containing protein	0.0069	0.0068	0.0062
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0039	0.0254
Echinococcus multilocularis	plexin a4	0.1023	0.2147	0.2561
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0056	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0069	0.0068	0.019
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0056	0.0039	0.004
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0056	0.0039	0.004
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0117	0.0174	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0068	0.0062
Echinococcus granulosus	Pleckstrin y	0.0069	0.0068	0.0075
Schistosoma mansoni	protein kinase	0.0056	0.0039	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0039	0.0254
Trichomonas vaginalis	conserved hypothetical protein	0.075	0.1553	1
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Trichomonas vaginalis	protein kinase atn1, putative	0.0056	0.0039	0.0254
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.075	0.1553	0.1541
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0074	0.008	0.5836
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0056	0.0039	0.004
Leishmania major	protein kinase, putative	0.0074	0.008	0.5836
Schistosoma mansoni	regulator of G protein signaling	0.075	0.1553	0.1541
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0069	0.0068	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0863	0.1797	0.1792
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0168	0.0284	0.0278
Plasmodium falciparum	protein kinase, putative	0.0074	0.008	0.5836
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0039	0.0034
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0056	0.0039	0.004
Echinococcus multilocularis	regulator of G protein signaling	0.075	0.1553	0.1851
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0068	0.0439
Onchocerca volvulus		0.0069	0.0068	0.0164
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0069	0.0068	0.4164
Loa Loa (eye worm)	hypothetical protein	0.075	0.1553	0.1548
Brugia malayi	hypothetical protein	0.0366	0.0716	0.071
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.008	0.0267
Brugia malayi	Variant SH3 domain containing protein	0.0069	0.0068	0.0062
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0069	0.0068	0.019
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0069	0.0068	0.019
Loa Loa (eye worm)	TK protein kinase	0.0056	0.0039	0.0034
Trichomonas vaginalis	AGC family protein kinase	0.0056	0.0039	0.0254
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0056	0.0039	0.004
Onchocerca volvulus		0.0069	0.0068	0.0164
Echinococcus multilocularis	tyrosine protein kinase csk	0.0056	0.0039	0.004
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0069	0.0068	0.0062
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.3878	0.8365	0.8364
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0056	0.0039	0.0034
Brugia malayi	Cadps2 protein	0.0069	0.0068	0.0062
Loa Loa (eye worm)	TK/CSK protein kinase	0.0056	0.0039	0.0034
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0087	0.0109	1
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.3878	0.8365	1
Schistosoma mansoni	oxysterol-binding protein 1	0.0069	0.0068	0.0054
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Brugia malayi	IPT/TIG domain containing protein	0.016	0.0268	0.0262
Echinococcus granulosus	regulator of G protein signaling 3	0.075	0.1553	0.1851
Onchocerca volvulus		0.0069	0.0068	0.0164
Brugia malayi	DNA-binding protein LAG-1	0.016	0.0268	0.0262
Onchocerca volvulus		0.0069	0.0068	0.0164
Brugia malayi	Pleckstrin Homology Domain	0.0069	0.0068	0.0062
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0056	0.0039	0.004
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0056	0.0039	0.0034
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0056	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.075	0.1553	1
Schistosoma mansoni	oxysterol-binding protein 1	0.0069	0.0068	0.0054
Brugia malayi	integrin-linked kinase	0.0056	0.0039	0.0034
Trypanosoma cruzi	hypothetical protein	0.0069	0.0068	0.4164
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0039	0.0254
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0039	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0068	0.0062
Echinococcus multilocularis	protein tyrosine kinase	0.0056	0.0039	0.004
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0039	0.0034
Echinococcus granulosus	regulator of G protein signaling 7	0.075	0.1553	0.1851
Echinococcus granulosus	roundabout 2	0.0117	0.0174	0.0201
Loa Loa (eye worm)	RGS-3 protein	0.075	0.1553	0.1548
Echinococcus granulosus	defective proboscis extension response	0.0112	0.0163	0.0188
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0069	0.0068	0.4164
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0069	0.0068	0.0054
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0056	0.0039	0.0034
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Entamoeba histolytica	hypothetical protein	0.0069	0.0068	0.019
Echinococcus multilocularis	Immunoglobulin	0.0112	0.0163	0.0188
Trichomonas vaginalis	alpha chimerin, putative	0.0069	0.0068	0.0439
Trypanosoma cruzi	hypothetical protein	0.0069	0.0068	0.4164
Schistosoma mansoni	serine/threonine protein kinase	0.0056	0.0039	0.0026
Echinococcus multilocularis	oxysterol binding protein 1	0.0069	0.0068	0.0075
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0056	0.0039	0.0034
Loa Loa (eye worm)	rho-GTPase-activating	0.0069	0.0068	0.0062
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0069	0.0068	0.0439
Trypanosoma cruzi	PH domain containing protein, putative	0.0069	0.0068	0.4164
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0163	0.0157
Schistosoma mansoni	protein kinase	0.0056	0.0039	0.0026
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0069	0.0068	0.019
Schistosoma mansoni	hypothetical protein	0.0069	0.0068	0.0054
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0056	0.0039	0.0034
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.3878	0.8365	1
Schistosoma mansoni	z-protein (S1r protein)	0.075	0.1553	0.1541
Brugia malayi	PH domain containing protein	0.0069	0.0068	0.0062
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0089	0.0574
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0039	0.0034
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0069	0.0068	0.0075
Echinococcus granulosus	cytohesin 1	0.0069	0.0068	0.0075
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0068	0.0439
Trypanosoma cruzi	NIMA-related kinase, putative	0.0087	0.0109	1
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0056	0.0039	0.004
Loa Loa (eye worm)	TK/ACK protein kinase	0.0056	0.0039	0.0034
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.016	0.0268	0.1723
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Echinococcus granulosus	G protein coupled receptor kinase 1	0.2797	0.6011	0.7184
Trypanosoma cruzi	hypothetical protein	0.0069	0.0068	0.4164
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0039	0.0034
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Echinococcus multilocularis	transfer RNA-Thr	0.0056	0.0039	0.004
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0056	0.0039	0.004
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0069	0.0068	0.019
Loa Loa (eye worm)	TK/DDR protein kinase	0.0056	0.0039	0.0034
Loa Loa (eye worm)	TK protein kinase	0.0056	0.0039	0.0034
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0087	0.0109	1
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0087	0.0109	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0163	0.0157
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0087	0.0109	0.0699
Schistosoma mansoni	protein kinase	0.0056	0.0039	0.0026
Brugia malayi	Guanylyl cyclase protein 23	0.0056	0.0039	0.0034
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0068	0.0439
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0089	0.0574
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0056	0.0039	0.004
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Brugia malayi	Protein kinase domain containing protein	0.0295	0.0562	0.0556
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Schistosoma mansoni	plexin	0.0497	0.1	0.0987
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.0268	0.1723
Entamoeba histolytica	hypothetical protein	0.0069	0.0068	0.019
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0069	0.0068	0.019
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0056	0.0039	0.004
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0056	0.0039	0.004
Echinococcus granulosus	protein tyrosine kinase	0.0056	0.0039	0.004
Echinococcus granulosus	transcription factor collier	0.016	0.0268	0.0313
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Toxoplasma gondii	Oxysterol-binding protein	0.0069	0.0068	0.4164
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0039	0.0034
Loa Loa (eye worm)	hypothetical protein	0.075	0.1553	0.1548
Loa Loa (eye worm)	hypothetical protein	0.0497	0.1	0.0995
Entamoeba histolytica	hypothetical protein	0.075	0.1553	1
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Entamoeba histolytica	hypothetical protein	0.0069	0.0068	0.019
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Echinococcus multilocularis	Oxysterol binding protein 11	0.0069	0.0068	0.0075
Loa Loa (eye worm)	hypothetical protein	0.075	0.1553	0.1548
Echinococcus granulosus	tyrosine kinase	0.0056	0.0039	0.004
Schistosoma mansoni	protein kinase	0.0078	0.0089	0.0075
Echinococcus granulosus	beta-adrenergic receptor kinase	0.3547	0.7646	0.914
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0068	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0174	0.0168
Loa Loa (eye worm)	sema domain-containing protein	0.0366	0.0716	0.071
Echinococcus multilocularis	activated cdc42 kinase 1	0.0056	0.0039	0.004
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Schistosoma mansoni	zinc finger protein	0.0069	0.0068	0.0054
Echinococcus granulosus	activated cdc42 kinase 1	0.0056	0.0039	0.004
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0078	0.0089	0.01
Loa Loa (eye worm)	hypothetical protein	0.016	0.0268	0.0262
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0069	0.0068	0.019
Schistosoma mansoni	hypothetical protein	0.016	0.0268	0.0254
Entamoeba histolytica	PH domain containing protein	0.0069	0.0068	0.019
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0069	0.0068	0.0075
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Schistosoma mansoni	hypothetical protein	0.0497	0.1	0.0987
Brugia malayi	Regulator of G protein signaling domain containing protein	0.075	0.1553	0.1548
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0056	0.0039	0.004
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0056	0.0039	0.004
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.075	0.1553	0.1548
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Echinococcus granulosus	Immunoglobulin	0.0112	0.0163	0.0188
Echinococcus granulosus	Pleckstrin y	0.0069	0.0068	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Echinococcus granulosus	semaphorin 1A	0.0366	0.0716	0.0849
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0056	0.0039	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0366	0.0716	0.071
Echinococcus multilocularis	beta adrenergic receptor kinase	0.3547	0.7646	0.914
Schistosoma mansoni	serine/threonine RGC	0.0056	0.0039	0.0026
Loa Loa (eye worm)	plexin A	0.1023	0.2147	0.2142
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.075	0.1553	0.1541
Entamoeba histolytica	protein kinase domain containing protein	0.0216	0.0389	0.2308
Trichomonas vaginalis	centaurin alpha, putative	0.0069	0.0068	0.0439
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.016	0.0268	0.1723
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0069	0.0068	0.0075
Entamoeba histolytica	hypothetical protein	0.016	0.0268	0.1508
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0056	0.0039	0.0034
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0039	0.0034
Echinococcus multilocularis	activin receptor type	0.0074	0.008	0.0089
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0087	0.0109	0.0457
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0087	0.0109	1
Brugia malayi	hypothetical protein	0.075	0.1553	0.1548
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0074	0.008	0.5836
Schistosoma mansoni	rho gtpase activating protein	0.0069	0.0068	0.0054
Loa Loa (eye worm)	hypothetical protein	0.016	0.0268	0.0262
Echinococcus granulosus	oxysterol binding protein 1	0.0069	0.0068	0.0075
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0163	0.0157
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0087	0.0109	1
Schistosoma mansoni	protein kinase	0.0056	0.0039	0.0026
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0069	0.0068	0.0164
Schistosoma mansoni	serine/threonine protein kinase	0.0056	0.0039	0.0026
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0069	0.0068	0.0054
Schistosoma mansoni	cell adhesion molecule	0.0117	0.0174	0.016
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0069	0.0068	0.019
Echinococcus granulosus	c src tyrosine kinase	0.0056	0.0039	0.004
Echinococcus granulosus	regulator of G protein signaling 3	0.075	0.1553	0.1851
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0087	0.0109	0.0457
Brugia malayi	Tyrosine-protein kinase PR2	0.0056	0.0039	0.0034
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0087	0.0109	0.0457
Echinococcus granulosus	natriuretic peptide receptor 1	0.0056	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.075	0.1553	1
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Trichomonas vaginalis	conserved hypothetical protein	0.075	0.1553	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0056	0.0039	0.0254
Brugia malayi	serine/threonine kinase 12	0.0078	0.0089	0.0083
Entamoeba histolytica	protein kinase, putative	0.0087	0.0109	0.0457
Leishmania major	hypothetical protein, conserved	0.0069	0.0068	0.4164
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0056	0.0039	0.0254
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Brugia malayi	Dynamin	0.0069	0.0068	0.0062
Entamoeba histolytica	hypothetical protein	0.016	0.0268	0.1508
Brugia malayi	hypothetical protein	0.0056	0.0039	0.0034
Leishmania major	protein kinase, putative	0.0087	0.0109	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0039	0.0034
Echinococcus multilocularis	insulin receptor	0.0056	0.0039	0.004
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Echinococcus multilocularis	regulator of G protein signaling 7	0.075	0.1553	0.1851
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0056	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0068	0.0439
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0069	0.0068	0.4164
Schistosoma mansoni	serine/threonine protein kinase	0.3547	0.7646	0.7643
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0056	0.0039	0.004
Leishmania major	protein kinase, putative	0.0087	0.0109	1
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Entamoeba histolytica	protein kinase, putative	0.0078	0.0089	0.0328
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0039	0.0034
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Schistosoma mansoni	axis inhibition protein axin	0.075	0.1553	0.1541
Onchocerca volvulus	Protein melted homolog	0.0069	0.0068	0.0164
Loa Loa (eye worm)	TK protein kinase	0.0056	0.0039	0.0034
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0056	0.0039	0.0034
Echinococcus multilocularis	epidermal growth factor receptor	0.0056	0.0039	0.004
Trichomonas vaginalis	protein transport protein sec7, putative	0.0069	0.0068	0.0439
Echinococcus granulosus	insulin receptor	0.0056	0.0039	0.004
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.4628	1	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0039	0.0034
Brugia malayi	Dynamin	0.0069	0.0068	0.0062
Schistosoma mansoni	regulator of G protein signaling	0.075	0.1553	0.1541
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0056	0.0039	0.004
Loa Loa (eye worm)	Plekhf2 protein	0.0069	0.0068	0.0062
Brugia malayi	SH2 domain containing protein	0.0056	0.0039	0.0034
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Schistosoma mansoni	nephrin	0.0117	0.0174	0.016
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0069	0.0068	0.0439
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0087	0.0109	1
Schistosoma mansoni	hypothetical protein	0.0056	0.0039	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0068	0.0439
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0056	0.0039	0.004
Trichomonas vaginalis	centaurin beta, putative	0.0069	0.0068	0.0439
Entamoeba histolytica	protein kinase domain containing protein	0.0078	0.0089	0.0328
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0089	0.0574
Echinococcus granulosus	tyrosine protein kinase csk	0.0056	0.0039	0.004
Schistosoma mansoni	tyrosine protein kinase	0.0056	0.0039	0.0026
Entamoeba histolytica	cell surface protease gp63, putative	0.016	0.0268	0.1508
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0039	0.0034
Echinococcus multilocularis	expressed protein	0.075	0.1553	0.1851
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0069	0.0068	0.0054
Loa Loa (eye worm)	cytohesin 3	0.0069	0.0068	0.0062
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.075	0.1553	0.1541
Echinococcus multilocularis	axis inhibition protein axin	0.075	0.1553	0.1851
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Loa Loa (eye worm)	TK/RYK protein kinase	0.0056	0.0039	0.0034
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0069	0.0068	0.019
Trypanosoma cruzi	hypothetical protein	0.0069	0.0068	0.4164
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0056	0.0039	0.004
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0087	0.0109	1
Echinococcus granulosus	Oxysterol binding protein 11	0.0069	0.0068	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Echinococcus multilocularis	transcription factor collier	0.016	0.0268	0.0313
Brugia malayi	Sema domain containing protein	0.0366	0.0716	0.071
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.0268	0.1723
Schistosoma mansoni	semaphorin 5-related	0.0366	0.0716	0.0703
Schistosoma mansoni	axis inhibition protein axin	0.075	0.1553	0.1541
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0069	0.0068	0.0439
Echinococcus granulosus	tyrosine protein kinase pr2	0.0056	0.0039	0.004
Brugia malayi	SRC-1	0.0056	0.0039	0.0034
Schistosoma mansoni	ephrin receptor	0.0056	0.0039	0.0026
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Plasmodium vivax	PH domain containing protein	0.0069	0.0068	0.4164
Loa Loa (eye worm)	TK/ROR protein kinase	0.0056	0.0039	0.0034
Echinococcus multilocularis	Pleckstrin y	0.0069	0.0068	0.0075
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0068	0.0439
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0056	0.0039	0.004
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Plasmodium vivax	hypothetical protein, conserved	0.0069	0.0068	0.4164
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0087	0.0109	1
Plasmodium falciparum	oxysterol-binding protein, putative	0.0069	0.0068	0.4164
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0039	0.0034
Echinococcus granulosus	activin receptor type	0.0074	0.008	0.0089
Loa Loa (eye worm)	TK/FAK protein kinase	0.0056	0.0039	0.0034
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Entamoeba histolytica	PH domain containing protein	0.0069	0.0068	0.019
Loa Loa (eye worm)	TK protein kinase	0.0056	0.0039	0.0034
Loa Loa (eye worm)	serine/threonine protein kinase	0.0056	0.0039	0.0034
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Trypanosoma cruzi	PH domain containing protein, putative	0.0069	0.0068	0.4164
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Schistosoma mansoni	protein kinase	0.0056	0.0039	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0039	0.0034
Brugia malayi	serine/threonine protein kinase 6	0.0078	0.0089	0.0083
Leishmania major	protein kinase, putative	0.0078	0.0089	0.7179
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0069	0.0068	0.0439
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Echinococcus granulosus	tyrosine protein kinase	0.0056	0.0039	0.004
Onchocerca volvulus		0.0069	0.0068	0.0164
Echinococcus multilocularis	myotubularin protein 13	0.0069	0.0068	0.0075
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0056	0.0039	0.0034
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Schistosoma mansoni	protein kinase	0.0056	0.0039	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0068	0.0439
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0068	0.0439
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0078	0.0089	0.0328
Echinococcus multilocularis	regulator of G protein signaling 3	0.075	0.1553	0.1851
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Trypanosoma cruzi	hypothetical protein	0.0069	0.0068	0.4164
Brugia malayi	plexin A	0.1023	0.2147	0.2142
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0069	0.0068	0.0075
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Loa Loa (eye worm)	AUR protein kinase	0.0078	0.0089	0.0083
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0069	0.0068	0.0062
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Echinococcus granulosus	plexin a4	0.1023	0.2147	0.2561
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0168	0.0284	0.0278
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0069	0.0068	0.0062
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0069	0.0068	0.0075
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0039	0.0034
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0074	0.008	0.0089
Entamoeba histolytica	hypothetical protein	0.0069	0.0068	0.019
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0056	0.0039	0.004
Loa Loa (eye worm)	TK/ABL protein kinase	0.0056	0.0039	0.0034
Loa Loa (eye worm)	sema domain-containing protein	0.0366	0.0716	0.071
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0056	0.0039	0.0034
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.0268	0.1723
Trichomonas vaginalis	TKL family protein kinase	0.0056	0.0039	0.0254
Echinococcus multilocularis	Pleckstrin y	0.0069	0.0068	0.0075
Brugia malayi	hypothetical protein	0.0056	0.0039	0.0034
Brugia malayi	A-kinase anchor protein 10, precursor	0.075	0.1553	0.1548
Schistosoma mansoni	serine/threonine protein kinase	0.4628	1	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0056	0.0039	0.004
Trichomonas vaginalis	conserved hypothetical protein	0.075	0.1553	1
Schistosoma mansoni	hypothetical protein	0.0069	0.0068	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0068	0.0062
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0078	0.0089	0.01
Schistosoma mansoni	tyrosine kinase	0.0056	0.0039	0.0026
Entamoeba histolytica	protein kinase , putative	0.0078	0.0089	0.0328
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0109	0.0699
Entamoeba histolytica	protein kinase, putative	0.0087	0.0109	0.0457
Onchocerca volvulus		0.0069	0.0068	0.0164
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0087	0.0109	1
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.2797	0.6011	0.7184
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0068	0.0062
Brugia malayi	C-terminal src kinase protein 1	0.0056	0.0039	0.0034
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0069	0.0068	0.4164
Schistosoma mansoni	protein kinase	0.0074	0.008	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0068	0.0062
Brugia malayi	hypothetical protein	0.0056	0.0039	0.0034
Echinococcus multilocularis	heat shock protein 70	0.0056	0.0039	0.004
Loa Loa (eye worm)	TK protein kinase	0.0056	0.0039	0.0034
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0056	0.0039	0.004

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 100 uM	Antiproliferative activity against human CCRF-CEM cells after 48 hrs by MTT assay	ChEMBL.	18713666

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL483456

Bibliographic References

No literature references available for this target.

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Detailed information for compound 984526