Detailed information for compound 995233

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 362.352 | Formula: C17H17F3N6
  • H donors: 2 H acceptors: 3 LogP: 2.73 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: FC(c1cccc(c1)c1nnc2n1nc(cc2)NC1CCNCC1)(F)F
  • InChi: 1S/C17H17F3N6/c18-17(19,20)12-3-1-2-11(10-12)16-24-23-15-5-4-14(25-26(15)16)22-13-6-8-21-9-7-13/h1-5,10,13,21H,6-9H2,(H,22,25)
  • InChiKey: SENFEQVLOFSJFU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 10 Starlite/ChEMBL References
Homo sapiens mitogen-activated protein kinase 14 Starlite/ChEMBL References
Homo sapiens protein kinase C, theta Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL References
Homo sapiens fms-related tyrosine kinase 3 Starlite/ChEMBL References
Homo sapiens IL2-inducible T-cell kinase Starlite/ChEMBL References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens interleukin-1 receptor-associated kinase 4 Starlite/ChEMBL References
Homo sapiens Janus kinase 3 Starlite/ChEMBL References
Homo sapiens MET proto-oncogene, receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens spleen tyrosine kinase Starlite/ChEMBL References
Homo sapiens polo-like kinase 1 Starlite/ChEMBL References
Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL References
Homo sapiens Janus kinase 2 Starlite/ChEMBL References
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References
Homo sapiens aurora kinase A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K04440 c-Jun N-terminal kinase, putative Get druggable targets OG5_129677 All targets in OG5_129677
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131855 All targets in OG5_131855
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Stress-activated protein kinase jnk-1 Get druggable targets OG5_129677 All targets in OG5_129677
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus c-Jun N-terminal kinases Get druggable targets OG5_129677 All targets in OG5_129677
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K04441 p38 MAP kinase, putative Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus tyrosine protein kinase shark Get druggable targets OG5_131855 All targets in OG5_131855
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase Get druggable targets OG5_129677 All targets in OG5_129677
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K05855 spleen tyrosine kinase, putative Get druggable targets OG5_131855 All targets in OG5_131855
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi P38 map kinase family protein 2 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus tyrosine protein kinase Btk29A Get druggable targets OG5_129320 All targets in OG5_129320
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative Get druggable targets OG5_134863 All targets in OG5_134863
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129677 All targets in OG5_129677
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_134863 All targets in OG5_134863
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma japonicum ko:K07370 Bruton agammaglobulinemia tyrosine kinase, putative Get druggable targets OG5_129320 All targets in OG5_129320
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131855 All targets in OG5_131855
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Get druggable targets OG5_132502 All targets in OG5_132502
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129320 All targets in OG5_129320
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis tyrosine protein kinase shark Get druggable targets OG5_131855 All targets in OG5_131855
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum IPR000164,Histone H3;IPR009072,Histone-fold,domain-containing Get druggable targets OG5_129677 All targets in OG5_129677
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis c Jun NH2 terminal kinase Get druggable targets OG5_129677 All targets in OG5_129677
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Tyrosine-protein kinase BTK, putative Get druggable targets OG5_129320 All targets in OG5_129320
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Onchocerca volvulus Serine\/threonine protein kinase homolog Get druggable targets OG5_134863 All targets in OG5_134863
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Serine/threonine-protein kinase Pim-3 Get druggable targets OG5_134863 All targets in OG5_134863
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis tyrosine protein kinase Btk29A Get druggable targets OG5_129320 All targets in OG5_129320
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 14 360 aa 336 aa 33.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0021 0.0018 0.0275
Leishmania major hypothetical protein, unknown function 0.0021 0.0018 0.0049
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0018 0.0054
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0029 0.0067 0.0384
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0077 0.0375 0.0375
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0021 0.0018 0.0018
Brugia malayi plexin A 0.0025 0.0041 0.019
Schistosoma mansoni hypothetical protein 0.002 0.0009 0.0049
Echinococcus multilocularis NCK adaptor protein 0.0027 0.0056 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Schistosoma mansoni tyrosine kinase 0.0041 0.0148 0.0849
Echinococcus multilocularis Zinc finger, PHD finger 0.0021 0.0018 0.0018
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0156 0.0881 0.2478
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0034 0.0098 0.0098
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.011 0.0587 0.9194
Echinococcus granulosus c src tyrosine kinase 0.0041 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0062 0.028 0.1609
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0022 0.0125
Loa Loa (eye worm) TK/FER protein kinase 0.0034 0.0101 0.0549
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0021 0.0018 0.0199
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0392
Echinococcus multilocularis tensin 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0392
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Echinococcus granulosus tyrosine protein kinase shark 0.029 0.1749 0.1749
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0077 0.0375 0.0375
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0118 0.0638 0.1795
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0021 0.0018 0.0275
Entamoeba histolytica protein kinase, putative 0.0072 0.0342 0.5355
Echinococcus multilocularis serine protein kinase ATM 0.0062 0.028 0.028
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0021 0.0018 0.0051
Echinococcus granulosus SHC transforming protein 3 0.002 0.0009 0.0009
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0062 0.028 0.0817
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0156 0.0881 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.011 0.0587 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0047 0.0271
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0072 0.0342 0.5355
Loa Loa (eye worm) hypothetical protein 0.0036 0.0116 0.0641
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.011 0.0587 0.6659
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0018 0.0054
Leishmania major phosphatidylinositol 3-kinase, putative 0.011 0.0587 0.165
Schistosoma mansoni tyrosine kinase 0.0077 0.0375 0.2143
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0239 0.3565
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0062 0.028 0.1598
Trypanosoma cruzi cdc2-related kinase 1 0.0056 0.0239 0.0698
Onchocerca volvulus 0.0021 0.0016 0.0066
Echinococcus granulosus mitogen activated protein kinase 14 0.0156 0.0881 0.0881
Loa Loa (eye worm) hypothetical protein 0.0167 0.0953 0.5608
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0018 0.0054
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0268 0.4036
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0069 0.0325 0.5537
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0021 0.0018 0.01
Brugia malayi Protein kinase domain containing protein 0.0034 0.0101 0.0549
Schistosoma mansoni shc transforming protein 0.002 0.0009 0.0049
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.011 0.0587 0.3356
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0047 0.0271
Trypanosoma cruzi cdc2-related kinase 3 0.0056 0.0239 0.0698
Brugia malayi RhoGAP domain containing protein 0.0029 0.0067 0.0348
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.0638 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Trypanosoma cruzi cdc2-related kinase 1 0.0056 0.0239 0.0698
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0021 0.0018 0.01
Loa Loa (eye worm) TK protein kinase 0.0069 0.0327 0.1892
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0075 0.0392
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0021 0.0018 0.0051
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0061 0.0277 0.1594
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0196 0.1141 0.6724
Brugia malayi serine/threonine-protein kinase 6 0.0072 0.0342 0.1979
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0021 0.0018 0.0299
Brugia malayi Variant SH3 domain containing protein 0.0027 0.0056 0.0282
Loa Loa (eye worm) TK/ABL protein kinase 0.0034 0.0101 0.0549
Brugia malayi SH2 domain containing protein 0.0034 0.0101 0.0549
Brugia malayi serine/threonine kinase 12 0.0072 0.0342 0.1979
Brugia malayi SRC-1 0.0077 0.0375 0.2174
Echinococcus granulosus SH2 domain containing adapter protein F 0.002 0.0009 0.0009
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0215 0.1262 0.744
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Echinococcus granulosus plexin a4 0.0025 0.0041 0.0041
Echinococcus multilocularis Immunoglobulin 0.003 0.0075 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.028 0.422
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0196 0.1141 0.6724
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0061 0.0277 0.1594
Onchocerca volvulus 0.0021 0.0018 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Entamoeba histolytica hypothetical protein 0.0021 0.0018 0.0275
Echinococcus granulosus neuroglian 0.0033 0.0093 0.0093
Brugia malayi Stress-activated protein kinase jnk-1 0.0282 0.1693 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0034 0.0101 0.0101
Echinococcus multilocularis SH2 motif 0.002 0.0009 0.0009
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0069 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0392
Trypanosoma brucei target of rapamycin kinase 3, putative 0.011 0.0587 0.6659
Echinococcus granulosus tyrosine protein kinase Fyn 0.0077 0.0375 0.0375
Entamoeba histolytica protein kinase, putative 0.0072 0.0342 0.5355
Brugia malayi Tyrosine-protein kinase abl-1 0.0041 0.0148 0.0831
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0069 0.0325 0.3687
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0021 0.0018 0.0199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.028 0.422
Entamoeba histolytica hypothetical protein 0.0062 0.028 0.4379
Toxoplasma gondii target of rapamycin (TOR), putative 0.011 0.0587 1
Schistosoma mansoni hypothetical protein 0.0048 0.0189 0.1083
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.011 0.0587 0.9194
Echinococcus granulosus protein kinase c epsilon type 0.0026 0.0047 0.0047
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0021 0.0018 0.0275
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.011 0.0587 0.165
Loa Loa (eye worm) phosphatidylinositol kinase 0.0021 0.0018 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.028 0.422
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0189 0.2767
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0342 0.5224
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0021 0.0018 0.01
Echinococcus granulosus tyrosine protein kinase Srms 0.0034 0.0101 0.0101
Onchocerca volvulus 0.0034 0.0101 0.0816
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0021 0.0018 0.0275
Echinococcus multilocularis cyclin dependent kinase 5 0.0056 0.0239 0.0239
Echinococcus multilocularis roundabout 2 0.0036 0.0116 0.0116
Loa Loa (eye worm) TK/FER protein kinase 0.0034 0.0101 0.0549
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0021 0.0018 0.01
Loa Loa (eye worm) hypothetical protein 0.0034 0.0101 0.0549
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0268 0.4036
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0021 0.0018 0.0275
Onchocerca volvulus 0.0034 0.0101 0.0816
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0072 0.0342 0.0342
Leishmania major protein kinase, putative 0.0072 0.0342 0.0961
Giardia lamblia Aurora kinase 0.0072 0.0342 0.5224
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.002 0.0009 0.0049
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.0638 1
Echinococcus multilocularis protein kinase c epsilon type 0.0026 0.0047 0.0047
Echinococcus multilocularis c src tyrosine kinase 0.0041 0.0148 0.0148
Leishmania major hypothetical protein, conserved 0.0572 0.3556 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0213 0.1215
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0072 0.0342 0.5355
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0638 0.365
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0018 0.0054
Echinococcus multilocularis cyclin dependent kinase 0.0056 0.0239 0.0239
Echinococcus multilocularis tyrosine protein kinase HCK 0.005 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0392
Trypanosoma cruzi hypothetical protein, conserved 0.0551 0.3421 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0021 0.0018 0.0051
Schistosoma mansoni growth factor receptor-bound protein 0.0027 0.0056 0.032
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0018 0.0054
Echinococcus granulosus suppressor of cytokine signaling 6 0.002 0.0009 0.0009
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0156 0.0881 0.2576
Trypanosoma cruzi aurora B kinase, putative 0.0072 0.0342 0.0999
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.0638 1
Echinococcus granulosus tyrosine protein kinase HCK 0.005 0.0201 0.0201
Echinococcus granulosus tensin 0.002 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Echinococcus multilocularis aurora kinase A 0.0072 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0392
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0072 0.0342 0.5355
Echinococcus granulosus tyrosine protein kinase Src64B 0.0077 0.0375 0.0375
Echinococcus granulosus tyrosine protein kinase Src42A 0.0077 0.0375 0.0375
Echinococcus granulosus tyrosine protein kinase Src42A 0.0055 0.0235 0.0235
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0062 0.028 0.028
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Echinococcus multilocularis mitogen activated protein kinase 11 0.0156 0.0881 0.0881
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0021 0.0018 0.0199
Entamoeba histolytica protein kinase, putative 0.005 0.0201 0.3144
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0118 0.0638 0.0638
Entamoeba histolytica cell division protein kinase 2, putative 0.0056 0.0239 0.3742
Loa Loa (eye worm) hypothetical protein 0.0048 0.0189 0.1073
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0062 0.028 0.028
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0342 0.5224
Schistosoma mansoni vav2 0.003 0.0078 0.0445
Echinococcus granulosus SH2 domain containing protein 7 0.002 0.0009 0.0009
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0196 0.1141 0.1141
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Loa Loa (eye worm) phosphatidylinositol 3 0.011 0.0587 0.3434
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0239 0.1366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.028 0.422
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0077 0.0375 0.0375
Brugia malayi intracellular kinase 0.0061 0.0277 0.1594
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.0638 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0063
Schistosoma mansoni tyrosine kinase 0.0194 0.113 0.6464
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.002 0.0009 0.0009
Echinococcus multilocularis SH2 motif 0.002 0.0009 0.0009
Giardia lamblia GTOR 0.011 0.0587 0.9172
Giardia lamblia Kinase, PLK 0.0118 0.0638 1
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0072 0.0342 0.0342
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.0638 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0021 0.0018 0.0051
Plasmodium vivax protein kinase Crk2 0.0056 0.0239 0.6825
Entamoeba histolytica protein kinase domain containing protein 0.0061 0.0277 0.4339
Echinococcus multilocularis Immunoglobulin 0.003 0.0075 0.0075
Entamoeba histolytica serine/threonine protein kinase, putative 0.0118 0.0638 1
Echinococcus multilocularis SHC transforming protein 3 0.002 0.0009 0.0009
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0077 0.0375 0.0375
Echinococcus granulosus tyrosine protein kinase Fyn 0.0077 0.0375 0.0375
Loa Loa (eye worm) plexin A 0.0025 0.0041 0.019
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0021 0.0018 0.0049
Echinococcus granulosus cyclin dependent kinase 1 0.0056 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.028 0.422
Brugia malayi Protein kinase domain containing protein 0.0034 0.0101 0.0549
Echinococcus granulosus cyclin dependent kinase 5 0.0056 0.0239 0.0239
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0062 0.028 0.1609
Echinococcus granulosus Protein kinase C brain isozyme 0.0026 0.0047 0.0047
Entamoeba histolytica protein kinase, putative 0.0061 0.0277 0.4339
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0033 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Schistosoma mansoni suppressor of cytokine signaling 0.002 0.0009 0.0049
Onchocerca volvulus 0.0167 0.0953 0.8341
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0056 0.0239 0.0672
Toxoplasma gondii FATC domain-containing protein 0.0062 0.028 0.4763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0325 0.4952
Echinococcus multilocularis suppressor of cytokine signaling 7 0.002 0.0009 0.0009
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0021 0.0018 0.01
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0077 0.0375 0.0375
Entamoeba histolytica protein kinase , putative 0.0072 0.0342 0.5355
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0021 0.0018 0.0299
Brugia malayi Sex muscle abnormal protein 5 0.0027 0.0056 0.0282
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0021 0.0018 0.0018
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0072 0.0342 1
Onchocerca volvulus Tyrosine kinase homolog 0.0184 0.1064 0.932
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0021 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0167 0.0953 0.5608
Echinococcus granulosus mitogen activated protein kinase 11 0.0156 0.0881 0.0881
Echinococcus granulosus serine protein kinase ATM 0.0062 0.028 0.028
Onchocerca volvulus 0.0061 0.0277 0.237
Echinococcus granulosus SH2 motif 0.002 0.0009 0.0009
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0048 0.0189 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Loa Loa (eye worm) TK/FER protein kinase 0.0034 0.0101 0.0549
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Schistosoma mansoni tensin-related 0.002 0.0009 0.0049
Echinococcus granulosus tyrosine kinase 0.0069 0.0327 0.0327
Echinococcus granulosus SH2 motif 0.002 0.0009 0.0009
Leishmania major phosphatidylinositol 3-related kinase, putative 0.011 0.0587 0.165
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Leishmania major phosphatidylinositol 3-kinase, putative 0.0021 0.0018 0.0049
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0282 0.1693 1
Loa Loa (eye worm) TK/FER protein kinase 0.0034 0.0101 0.0549
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0069 0.0327 0.0327
Mycobacterium leprae conserved hypothetical protein 0.0021 0.0018 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0034 0.0101 0.0549
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0054
Echinococcus multilocularis tyrosine protein kinase Srms 0.0069 0.0327 0.0327
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.1141 0.6524
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0061 0.0277 0.0779
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.011 0.0587 0.1716
Giardia lamblia Kinase, CMGC CDK 0.0056 0.0239 0.3565
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.011 0.0587 0.6659
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Echinococcus multilocularis basement membrane specific heparan sulfate 0.003 0.0075 0.0075
Onchocerca volvulus 0.0034 0.0101 0.0816
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0077 0.0375 0.0375
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.002 0.0009 0.0009
Brugia malayi serine/threonine protein kinase 6 0.0072 0.0342 0.1979
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0021 0.0018 0.0514
Schistosoma mansoni hypothetical protein 0.002 0.0009 0.0049
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0018 0.0054
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0026 0.0047 0.0047
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0021 0.0018 0.0275
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.011 0.0587 0.165
Schistosoma mansoni adapter molecule crk 0.0027 0.0056 0.032
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0024 0.0034 0.0536
Onchocerca volvulus 0.0034 0.0101 0.0816
Brugia malayi SH2 domain containing protein 0.0034 0.0101 0.0549
Schistosoma mansoni tensin-related 0.002 0.0009 0.0049
Trypanosoma brucei cdc2-related kinase 1 0.0056 0.0239 0.271
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0034 0.0101 0.0101
Echinococcus granulosus protein kinase c iota type 0.0026 0.0047 0.0047
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.011 0.0587 0.3434
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0041 0.0148 0.0849
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0144 0.2035
Echinococcus granulosus NCK adaptor protein 0.0027 0.0056 0.0056
Echinococcus granulosus roundabout 2 0.0036 0.0116 0.0116
Schistosoma mansoni hypothetical protein 0.0021 0.0018 0.01
Echinococcus multilocularis protein kinase shaggy 0.0061 0.0277 0.0277
Brugia malayi FAT domain containing protein 0.0048 0.0189 0.1073
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.011 0.0587 0.1716
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Echinococcus multilocularis cyclin dependent kinase 1 0.0056 0.0239 0.0239
Schistosoma mansoni tensin 0.002 0.0009 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.011 0.0587 0.0587
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0156 0.0881 0.5182
Loa Loa (eye worm) hypothetical protein 0.0183 0.106 0.6242
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0062 0.028 0.1609
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0342 0.1955
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0027 0.0056 0.032
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0196 0.1141 0.1141
Entamoeba histolytica hypothetical protein 0.0021 0.0018 0.0275
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0077 0.0375 0.0375
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0021 0.0018 0.0299
Echinococcus granulosus expressed conserved protein 0.002 0.0009 0.0009
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0196 0.1141 0.6724
Echinococcus multilocularis 0.002 0.0009 0.0009
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0342 0.5224
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0277 0.4179
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0392
Schistosoma mansoni SH2A 0.002 0.0009 0.0049
Echinococcus granulosus aurora kinase A 0.0072 0.0342 0.0342
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.011 0.0587 0.0587
Brugia malayi Protein kinase domain containing protein 0.0034 0.0101 0.0549
Loa Loa (eye worm) AUR protein kinase 0.0072 0.0342 0.1979
Echinococcus multilocularis SH2 motif 0.002 0.0009 0.0009
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0077 0.0375 0.0375
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0061 0.0277 0.4719
Loa Loa (eye worm) hypothetical protein 0.0069 0.0325 0.1879
Echinococcus multilocularis mitogen activated protein kinase 14 0.0156 0.0881 0.0881
Schistosoma mansoni tyrosine-protein kinase zap-70 0.002 0.0009 0.0049
Giardia lamblia Kinase, CMGC GSK 0.0061 0.0277 0.4179
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Schistosoma mansoni growth factor receptor-bound protein 0.0027 0.0056 0.032
Echinococcus multilocularis mitogen activated protein kinase 14 0.0156 0.0881 0.0881
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Schistosoma mansoni Neurotrimin precursor (hNT) 0.003 0.0075 0.0426
Schistosoma mansoni nck2/grb4 0.0027 0.0056 0.032
Echinococcus granulosus tyrosine protein kinase Blk 0.0069 0.0327 0.0327
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.0018 0.0514
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0056 0.0239 0.0239
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0021 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.011 0.0587 0.165
Echinococcus multilocularis neuroglian 0.0033 0.0093 0.0093
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0202 0.1178 0.1178
Echinococcus multilocularis cyclin dependent kinase 1 0.0056 0.0239 0.0239
Loa Loa (eye worm) TK/FER protein kinase 0.0034 0.0101 0.0549
Schistosoma mansoni kinase 0.0062 0.0278 0.1588
Echinococcus multilocularis tyrosine protein kinase shark 0.029 0.1749 0.1749
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0027 0.0056 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Trypanosoma cruzi polo-like protein kinase, putative 0.0118 0.0638 0.1866
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Echinococcus multilocularis tyrosine protein kinase Blk 0.0069 0.0327 0.0327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0144 0.2035
Echinococcus multilocularis growth factor receptor bound protein 2 0.0027 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0036 0.0116 0.0641
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0055 0.0235 0.0235
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0021 0.0018 0.01
Plasmodium falciparum protein kinase 5 0.0056 0.0239 0.6988
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0056 0.0239 0.1368
Trypanosoma brucei aurora B kinase 0.0072 0.0342 0.3879
Entamoeba histolytica protein kinase domain containing protein 0.0061 0.0277 0.4339
Echinococcus granulosus tyrosine protein kinase Lyn 0.0081 0.04 0.04
Echinococcus multilocularis protein kinase c iota type 0.0026 0.0047 0.0047
Brugia malayi hypothetical protein 0.0034 0.0101 0.0549
Echinococcus granulosus suppressor of cytokine signaling 7 0.002 0.0009 0.0009
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0021 0.0018 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0021 0.0018 0.0051
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0061 0.0277 0.1584
Onchocerca volvulus Serine\/threonine kinase homolog 0.0118 0.0638 0.5561
Schistosoma mansoni tensin 0.002 0.0009 0.0049
Echinococcus multilocularis suppressor of cytokine signaling 6 0.002 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.011 0.0587 0.3434
Echinococcus granulosus defective proboscis extension response 0.003 0.0075 0.0075
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0018 0.0054
Giardia lamblia Kinase, CMGC CDK 0.0056 0.0239 0.3565
Loa Loa (eye worm) TK/FER protein kinase 0.0034 0.0101 0.0549
Entamoeba histolytica protein kinase, putative 0.0024 0.0034 0.0536
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0021 0.0018 0.0299
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.002 0.0009 0.0009
Echinococcus multilocularis mitogen activated protein kinase 11 0.0156 0.0881 0.0881
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0118 0.0638 0.3739
Onchocerca volvulus 0.0034 0.0101 0.0816
Brugia malayi Plexin repeat family protein 0.0021 0.0016 0.0044
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0118 0.0638 0.0638
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0077 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0176 0.1012 0.5956
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0021 0.0018 0.0051
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.002 0.0009 0.0009
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0062 0.028 0.0817
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0056 0.0239 0.0672
Brugia malayi Protein kinase domain containing protein 0.0056 0.0239 0.1368
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0061 0.0277 0.0277
Echinococcus granulosus N chimaerin 0.0029 0.0067 0.0067
Brugia malayi Fibronectin type III domain containing protein 0.003 0.0075 0.0392
Loa Loa (eye worm) hypothetical protein 0.0034 0.0098 0.0531
Schistosoma mansoni atypical protein kinase C 0.0026 0.0047 0.0271
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0021 0.0018 0.0275
Echinococcus multilocularis suppressor of cytokine signaling 7 0.002 0.0009 0.0009
Brugia malayi cell division control protein 2 homolog 0.0056 0.0239 0.1368
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0021 0.0018 0.0199
Leishmania major phosphatidylinositol kinase, putative 0.0021 0.0018 0.0049
Brugia malayi Variant SH3 domain containing protein 0.0021 0.0019 0.0063
Echinococcus multilocularis tensin 0.002 0.0009 0.0009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0215 0.1262 0.744
Schistosoma mansoni cell adhesion molecule 0.0034 0.0098 0.0561
Schistosoma mansoni tensin 0.002 0.0009 0.0049
Echinococcus multilocularis raf serine:threonine protein kinase 0.0024 0.0033 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.0282 0.1693 0.968
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0021 0.0018 0.01
Schistosoma mansoni protein kinase 0.0072 0.0342 0.1955
Schistosoma mansoni tyrosine kinase 0.0041 0.0148 0.0849
Schistosoma mansoni signal transduction protein lnk-related 0.002 0.0009 0.0049
Echinococcus granulosus raf serine:threonine protein kinase 0.0024 0.0033 0.0033
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0029 0.0067 0.0067
Schistosoma mansoni nephrin 0.0033 0.0093 0.0532
Loa Loa (eye worm) hypothetical protein 0.0041 0.0144 0.0804
Echinococcus multilocularis plexin a4 0.0025 0.0041 0.0041
Echinococcus granulosus protein kinase shaggy 0.0061 0.0277 0.0277
Brugia malayi hypothetical protein 0.003 0.0075 0.0392
Schistosoma mansoni fkbp-rapamycin associated protein 0.0062 0.028 0.1598
Trypanosoma brucei protein kinase, putative 0.0061 0.0277 0.3142
Onchocerca volvulus 0.0034 0.0101 0.0816
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0018 0.0199
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0021 0.0018 0.0514
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.011 0.0587 0.6659
Schistosoma mansoni tyrosine kinase 0.0271 0.1622 0.9276
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.0638 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0077 0.0375 0.0375
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0027 0.0056 0.0282
Echinococcus granulosus tyrosine protein kinase ABL1 0.0034 0.0101 0.0101
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0021 0.0018 0.0018
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0021 0.0018 0.0054
Brugia malayi serine/threonine-protein kinase plk-2 0.0118 0.0638 0.3739
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0239 0.1366
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0077 0.0375 0.0375
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0021 0.0018 0.0018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0018 0.0054
Schistosoma mansoni tyrosine kinase 0.0077 0.0375 0.2143
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0021 0.0018 0.0051
Echinococcus granulosus c-Jun N-terminal kinases 0.0282 0.1693 0.1693
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0021 0.0018 0.0018
Entamoeba histolytica hypothetical protein 0.0021 0.0018 0.0275
Trypanosoma brucei cdc2-related kinase 3 0.0056 0.0239 0.271
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0021 0.0018 0.0299
Plasmodium falciparum serine/threonine protein kinase, putative 0.0072 0.0342 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0026 0.0047 0.0231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.028 0.422
Loa Loa (eye worm) TK/FER protein kinase 0.0034 0.0101 0.0549
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0239 0.3565
Entamoeba histolytica protein kinase domain containing protein 0.0072 0.0342 0.5355
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0061 0.0277 0.081
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0021 0.0018 0.0018
Schistosoma mansoni plexin 0.0021 0.0016 0.0092
Echinococcus granulosus tyrosine kinase 0.0034 0.0101 0.0101
Loa Loa (eye worm) AUR protein kinase 0.0072 0.0342 0.1979
Echinococcus granulosus tensin C1 domain containing phosphatase 0.002 0.0009 0.0009
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0018 0.0051
Schistosoma mansoni tyrosine kinase 0.029 0.1749 1
Schistosoma mansoni suppressor of cytokine signaling 0.002 0.0009 0.0049
Trypanosoma cruzi polo-like protein kinase, putative 0.0118 0.0638 0.1866
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0041 0.0144 0.0421
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0077 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0044
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0029 0.0067 0.0348
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0021 0.0019 0.0063
Loa Loa (eye worm) SRC-1 0.0077 0.0375 0.2174
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0021 0.0018 0.0051
Echinococcus granulosus hypothetical protein 0.002 0.0009 0.0009
Brugia malayi Protein kinase domain containing protein 0.0196 0.1141 0.6724
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.011 0.0587 0.6659
Echinococcus granulosus cyclin dependent kinase 0.0056 0.0239 0.0239
Plasmodium falciparum glycogen synthase kinase 3 0.0061 0.0277 0.8102
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.002 0.0009 0.0009
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0021 0.0018 0.0018
Loa Loa (eye worm) TK/FER protein kinase 0.0034 0.0101 0.0549
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0056 0.0239 0.407
Echinococcus multilocularis tyrosine kinase 0.0034 0.0101 0.0101
Brugia malayi protein-tyrosine kinase 0.0069 0.0327 0.1892
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0325 0.4952
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0196 0.1141 1
Loa Loa (eye worm) phosphatidylinositol 3 0.011 0.0587 0.3434
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0342 0.5224
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0239 0.3565
Trypanosoma cruzi cdc2-related kinase 3 0.0056 0.0239 0.0698
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0021 0.0018 0.0018
Loa Loa (eye worm) TK protein kinase 0.005 0.0201 0.1141
Schistosoma mansoni GTPase activating protein 0.002 0.0009 0.0049
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.011 0.0587 0.0587
Brugia malayi Protein kinase domain containing protein 0.0034 0.0101 0.0549
Echinococcus granulosus growth factor receptor bound protein 2 0.0027 0.0056 0.0056
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0018 0.5
Entamoeba histolytica protein kinase rad3, putative 0.0062 0.028 0.4379
Loa Loa (eye worm) TK/FER protein kinase 0.0034 0.0101 0.0549
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.1574 1 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0056 0.0239 0.3742
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.002 0.0009 0.0009
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0156 0.0881 0.2576
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0018 0.0054
Echinococcus multilocularis SH2 domain containing protein 7 0.002 0.0009 0.0009
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0202 0.1178 0.1178
Echinococcus multilocularis N chimaerin 0.0029 0.0067 0.0067
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0021 0.0018 0.0275
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.011 0.0587 0.1716
Onchocerca volvulus 0.0021 0.0018 0.008
Trypanosoma cruzi target of rapamycin kinase 3 0.011 0.0587 0.1716
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0056 0.0239 0.1368
Brugia malayi Variant SH3 domain containing protein 0.0027 0.0056 0.0282
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0282 0.1693 0.1693
Echinococcus multilocularis SH2 domain containing adapter protein F 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0167 0.0953 0.5608
Echinococcus granulosus twitchin 0.0037 0.0119 0.0119
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0062 0.028 0.3171
Entamoeba histolytica SH2 domain containing protein 0.002 0.0009 0.0134
Echinococcus granulosus Immunoglobulin 0.003 0.0075 0.0075
Schistosoma mansoni tyrosine kinase 0.0021 0.0016 0.0093
Loa Loa (eye worm) hypothetical protein 0.0027 0.0056 0.0282
Echinococcus multilocularis 0.0021 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.028 0.422
Echinococcus granulosus signal transduction protein lnk realted 0.002 0.0009 0.0009
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0021 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Brugia malayi protein kinase C II. 0.0026 0.0047 0.0231
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.003 0.0075 0.0426
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0062 0.028 0.4379
Leishmania major phosphatidylinositol 4-kinase, putative 0.0021 0.0018 0.0049
Loa Loa (eye worm) AUR protein kinase 0.0072 0.0342 0.1979
Schistosoma mansoni vesicular amine transporter 0.003 0.0075 0.0426
Echinococcus multilocularis signal transduction protein lnk realted 0.002 0.0009 0.0009
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0277 0.4179
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0029 0.0067 0.0067
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0029 0.0067 0.0384
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0034 0.0101 0.0101
Trypanosoma brucei polo-like protein kinase 0.0118 0.0638 0.7242
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0587 0.9172
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.0638 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.028 0.422
Brugia malayi P38 map kinase family protein 2 0.0156 0.0881 0.5182
Brugia malayi Protein kinase domain containing protein 0.0034 0.0101 0.0549
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0061 0.0277 0.0277
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0021 0.0018 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0047 0.0271
Leishmania major phosphatidylinositol kinase related protein, putative 0.0021 0.0018 0.0049
Onchocerca volvulus 0.0167 0.0953 0.8341
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.011 0.0587 0.1716
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0056 0.0239 0.1368
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0048 0.0189 0.0189
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0018 0.0054
Echinococcus multilocularis tyrosine protein kinase Abl 0.0041 0.0148 0.0148
Giardia lamblia Kinase, CMGC GSK 0.0061 0.0277 0.4179
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0034 0.0101 0.1581
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0021 0.0018 0.0275
Plasmodium vivax glycogen synthase kinase 3, putative 0.0061 0.0277 0.7999
Brugia malayi Variant SH3 domain containing protein 0.0029 0.0067 0.0348
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0021 0.0018 0.0018
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.011 0.0587 0.3356
Toxoplasma gondii aurora kinase 0.0072 0.0342 0.5825
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0018 0.0054

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) Inhibition of MAP3K7 ChEMBL. 19414255
Ki (binding) Inhibition of ERK2 ChEMBL. 19414255
Ki (binding) Inhibition of COT ChEMBL. 19414255
Ki (binding) = 21 nM Inhibition of Pim1 assessed as [32P] incorporation preincubated for 15 mins before ATP substrate addition by coupled spectrophotometric assay ChEMBL. 19414255
Ki (binding) = 800 nM Inhibition of Aurora 2 ChEMBL. 19414255
Ki (binding) = 1400 nM Inhibition of FLT3 ChEMBL. 19414255
Ki (binding) = 2900 nM Inhibition of GSK3-beta ChEMBL. 19414255
Ki (binding) > 4000 nM Inhibition of SYK ChEMBL. 19414255
Ki (binding) > 4000 nM Inhibition of SRC ChEMBL. 19414255
Ki (binding) > 4000 nM Inhibition of PLK1 ChEMBL. 19414255
Ki (binding) > 4000 nM Inhibition of PKCtheta ChEMBL. 19414255
Ki (binding) > 4000 nM Inhibition of p38alpha ChEMBL. 19414255
Ki (binding) > 4000 nM Inhibition of MET ChEMBL. 19414255
Ki (binding) > 4000 nM Inhibition of KDR ChEMBL. 19414255
Ki (binding) > 4000 nM Inhibition of JNK3 ChEMBL. 19414255
Ki (binding) > 4000 nM Inhibition of JAK3 ChEMBL. 19414255
Ki (binding) > 4000 nM Inhibition of JAK2 ChEMBL. 19414255
Ki (binding) > 4000 nM Inhibition of ITK ChEMBL. 19414255
Ki (binding) > 4000 nM Inhibition of IRAK4 ChEMBL. 19414255
Ki (binding) > 4000 nM Inhibition of CDK2 ChEMBL. 19414255

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.