pI: 8.2196 |
Length (AA): 906 |
MW (Da): 103928 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 42 | 1pls (A) | 6 | 48 | 12.00 | 0.89 | 0.01 | 0.0241576 | 1.07 |
1 | 94 | 2dn6 (A) | 9 | 103 | 14.00 | 0.00000000019 | 0.12 | 0.251553 | -0.22 |
108 | 148 | 3bdl (A) | 701 | 741 | 44.00 | 0.79 | 0.15 | 0.371654 | 1.22 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128363)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G16785 | phospholipase D P1 |
Arabidopsis thaliana | AT3G05630 | phospholipase D P2 |
Brugia malayi | Bm1_08640 | Phospholipase d protein 1 |
Candida albicans | CaO19.8753 | Phospholipase D:required for commitment to meiosis |
Candida albicans | CaO19.1161 | Phospholipase D:required for commitment to meiosis |
Caenorhabditis elegans | CELE_C04G6.3 | Protein PLD-1 |
Dictyostelium discoideum | DDB_G0279483 | phospholipase D1 |
Dictyostelium discoideum | DDB_G0277949 | phospholipase D1 |
Dictyostelium discoideum | DDB_G0281031 | phospholipase D1 |
Drosophila melanogaster | Dmel_CG12110 | Phospholipase D |
Echinococcus granulosus | EgrG_000249000 | phospholipase D |
Echinococcus granulosus | EgrG_000249100 | phospholipase D1 |
Entamoeba histolytica | EHI_146550 | phospholipase D, putative |
Entamoeba histolytica | EHI_146400 | phospholipase D active site domain-containing protein |
Entamoeba histolytica | EHI_082560 | phospholipase D, putative |
Echinococcus multilocularis | EmuJ_000249000 | phospholipase D |
Echinococcus multilocularis | EmuJ_000249100 | phospholipase D1 |
Homo sapiens | ENSG00000075651 | phospholipase D1, phosphatidylcholine-specific |
Homo sapiens | ENSG00000129219 | phospholipase D2 |
Loa Loa (eye worm) | LOAG_11567 | hypothetical protein |
Loa Loa (eye worm) | LOAG_11069 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14481 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13909 | hypothetical protein |
Mus musculus | ENSMUSG00000027695 | phospholipase D1 |
Mus musculus | ENSMUSG00000020828 | phospholipase D2 |
Oryza sativa | 4338532 | Os05g0358700 |
Oryza sativa | 9272440 | Os01g0310100 |
Saccharomyces cerevisiae | YKR031C | phospholipase D |
Schistosoma japonicum | Sjp_0081710 | ko:K01115 phospholipase D [EC3.1.4.4], putative |
Schistosoma japonicum | Sjp_0079810 | expressed protein |
Schistosoma japonicum | Sjp_0075670 | ko:K01115 phospholipase D [EC3.1.4.4], putative |
Schistosoma japonicum | Sjp_0105630 | Conserved hypothetical protein |
Schistosoma japonicum | Sjp_0079820 | Phospholipase D1, putative |
Schistosoma mansoni | Smp_151420 | phospholipase D |
Schmidtea mediterranea | mk4.001699.02 | Phospholipase D |
Schmidtea mediterranea | mk4.001699.04 | Phospholipase D |
Schmidtea mediterranea | mk4.001699.03 | Phospholipase D |
Schmidtea mediterranea | mk4.001699.01 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_C04G6.3 | Caenorhabditis elegans | slow growth | wormbase |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | phospholipase D1, phosphatidylcholine-specific | Compounds | References |
Homo sapiens | phospholipase D2 | Compounds | References |