Detailed information for compound 1301116

Basic information

Technical information
  • TDR Targets ID: 1301116
  • Name: [4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl ]-(2-methyl-3-nitrophenyl)methanone
  • MW: 383.398 | Formula: C20H21N3O5
  • H donors: 0 H acceptors: 3 LogP: 2.69 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc(c1C)[N+](=O)[O-])N1CCN(CC1)Cc1ccc2c(c1)OCO2
  • InChi: 1S/C20H21N3O5/c1-14-16(3-2-4-17(14)23(25)26)20(24)22-9-7-21(8-10-22)12-15-5-6-18-19(11-15)28-13-27-18/h2-6,11H,7-10,12-13H2,1H3
  • InChiKey: KRLRLLAUMXTMBA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-(2-methyl-3-nitro-phenyl)methanone
  • [4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-(2-methyl-3-nitrophenyl)methanone
  • Oprea1_398480
  • 1-(1,3-benzodioxol-5-ylmethyl)-4-(2-methyl-3-nitrobenzoyl)piperazine
  • MLS000678725
  • SMR000269787
  • STK030786

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0039 0.0136 0.3158
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0155 0.3665
Echinococcus multilocularis GRB2 associated binding protein 3 0.0039 0.0136 0.0136
Leishmania major hypothetical protein, conserved 0.0101 0.0403 0.1928
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.002 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.002 0.0013
Brugia malayi PXA domain containing protein 0.0101 0.0403 0.0396
Chlamydia trachomatis phospholipase D superfamily protein 0.0371 0.1574 0.5
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0039 0.0136 0.0128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0301 0.0835
Schistosoma mansoni nuclear hormone receptor 0.0012 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0403 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0393 0.0393
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Trypanosoma brucei PX domain containing protein, putative 0.0101 0.0403 0.1131
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0148 0.0148
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0008 0.0008
Giardia lamblia Hypothetical protein 0.0101 0.0403 0.5
Echinococcus granulosus cathepsin L 0.001 0.0012 0.0012
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0039 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.1509 0.6501 0.7743
Onchocerca volvulus 0.0039 0.0136 0.0628
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Giardia lamblia Hypothetical protein 0.0101 0.0403 0.5
Brugia malayi Phospholipase D. Active site motif family protein 0.0437 0.186 0.1854
Entamoeba histolytica PH domain containing protein kinase, putative 0.0039 0.0136 0.0123
Schistosoma mansoni sorting nexin 0.0101 0.0403 0.0403
Trypanosoma cruzi zinc finger protein kinase, putative 0.0101 0.0403 0.1131
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.002 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0055 0.1087
Schistosoma mansoni hypothetical protein 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0152
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0039 0.0136 0.0136
Loa Loa (eye worm) PX domain-containing protein 0.0101 0.0403 0.0471
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.002 0.002
Entamoeba histolytica hypothetical protein 0.0039 0.0136 0.0123
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0055 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0403 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0055 0.1087
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0039 0.0136 0.079
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0012 0.0019 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0301 0.0835
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.002 0.002
Brugia malayi PX domain containing protein 0.0101 0.0403 0.0396
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0136 0.3158
Loa Loa (eye worm) hypothetical protein 0.007 0.0271 0.0313
Brugia malayi nuclear receptor NHR-88 0.0012 0.002 0.0013
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0229 0.0628
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0039 0.0136 0.0136
Echinococcus multilocularis GA binding protein alpha chain 0.0082 0.0322 0.0322
Loa Loa (eye worm) beta-lactamase 0.0043 0.0155 0.0176
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0155 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0055 0.1087
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0039 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0014
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0039 0.0136 0.0123
Echinococcus granulosus ETS transcription factor Elf 1 0.0012 0.0019 0.0019
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.002 0.002
Trypanosoma cruzi cardiolipin synthetase, putative 0.0808 0.3466 1
Echinococcus multilocularis 0.0101 0.0403 0.0403
Plasmodium vivax vivapain-2 0.002 0.0055 0.0272
Brugia malayi PH domain containing protein 0.0039 0.0136 0.0128
Toxoplasma gondii Oxysterol-binding protein 0.0039 0.0136 0.0237
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Brugia malayi Cathepsin L-like precursor 0.002 0.0055 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0043 0.0155 0.0176
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0026 0.0014
Loa Loa (eye worm) rho-GTPase-activating 0.0039 0.0136 0.0152
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.002 0.002
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0039 0.0136 0.0448
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0039 0.0136 0.0357
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Brugia malayi Dynamin 0.0039 0.0136 0.0128
Brugia malayi PX domain containing protein 0.0101 0.0403 0.0396
Echinococcus granulosus phospholipase D1 0.2318 1 1
Trypanosoma cruzi hypothetical protein 0.0039 0.0136 0.0357
Echinococcus multilocularis oxysterol binding protein 9 0.0039 0.0136 0.0136
Echinococcus granulosus GA binding protein alpha chain 0.0082 0.0322 0.0322
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0039 0.0136 0.0357
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0301 0.0835
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0039 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.002 0.0014
Trichomonas vaginalis centaurin alpha, putative 0.0039 0.0136 0.3158
Echinococcus granulosus pleckstrin y domain containing family A 0.0039 0.0136 0.0136
Schistosoma mansoni vav2 0.0039 0.0136 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0301 0.0835
Entamoeba histolytica PH domain containing protein kinase, putative 0.0039 0.0136 0.0123
Echinococcus multilocularis sorting nexin 4 0.0101 0.0403 0.0403
Echinococcus multilocularis sorting nexin 0.0101 0.0403 0.0403
Schistosoma mansoni sorting nexin 0.0101 0.0403 0.0403
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0019 0.0019
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0039 0.0136 0.0357
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0026 0.0346
Schistosoma mansoni CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 0.0371 0.1574 0.1574
Brugia malayi Protein kinase domain containing protein 0.0039 0.0136 0.0128
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.002 0.002
Brugia malayi PH domain containing protein 0.0039 0.0136 0.0128
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0039 0.0136 0.0152
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0101 0.0403 0.0471
Echinococcus multilocularis dynamin 1 0.0039 0.0136 0.0136
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0101 0.0403 0.0403
Onchocerca volvulus Cathepsin F homolog 0.002 0.0055 0.0189
Brugia malayi ecdysteroid receptor 0.0012 0.002 0.0013
Brugia malayi Cathepsin L-like precursor 0.002 0.0055 0.0047
Brugia malayi PH domain containing protein 0.0039 0.0136 0.0128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.002 0.0014
Trypanosoma brucei PX domain containing protein, putative 0.0101 0.0403 0.1131
Entamoeba histolytica p21-activated kinase 0.0039 0.0136 0.0123
Echinococcus multilocularis phospholipase D 0.2047 0.8829 0.8829
Leishmania major serine/threonine-protein kinase a, putative 0.0039 0.0136 0.0448
Echinococcus multilocularis phospholipase D1 0.2318 1 1
Mycobacterium ulcerans beta-lactamase 0.0043 0.0155 1
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0039 0.0136 0.0136
Echinococcus multilocularis DCC interacting protein 13 beta 0.0039 0.0136 0.0136
Echinococcus granulosus cathepsin l1 0.002 0.0055 0.0055
Onchocerca volvulus 0.0039 0.0136 0.0628
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0039 0.0136 0.0123
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0039 0.0136 0.0123
Brugia malayi Syntrophin-1 0.0039 0.0136 0.0128
Brugia malayi CXXC zinc finger family protein 0.003 0.0099 0.0092
Echinococcus granulosus sorting nexin 6 0.0101 0.0403 0.0403
Trypanosoma cruzi hypothetical protein 0.0039 0.0136 0.0357
Echinococcus multilocularis actin binding protein anillin 0.0039 0.0136 0.0136
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Trichomonas vaginalis centaurin/arf, putative 0.0039 0.0136 0.3158
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0403 1
Entamoeba histolytica hypothetical protein 0.0039 0.0136 0.0123
Loa Loa (eye worm) hypothetical protein 0.0437 0.186 0.2208
Brugia malayi PX domain containing protein 0.0101 0.0403 0.0396
Schistosoma mansoni syntrophin 0.0039 0.0136 0.0136
Echinococcus granulosus sorting nexin 0.0101 0.0403 0.0403
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0301 0.0835
Echinococcus multilocularis phospholipase d3 0.0437 0.186 0.186
Echinococcus granulosus FTZ F1 alpha 0.0012 0.002 0.002
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0099 0.0109
Echinococcus granulosus dnaJ subfamily B 0.0434 0.1845 0.1845
Entamoeba histolytica hypothetical protein 0.0101 0.0403 0.0391
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.002 0.0014
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0039 0.0136 0.3158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0055 0.1087
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0039 0.0136 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0136 0.3158
Brugia malayi PH domain containing protein 0.0039 0.0136 0.0128
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0055 0.0042
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0393 0.0393
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0055 0.1087
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0039 0.0136 0.0123
Onchocerca volvulus 0.0014 0.0026 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.002 0.0013
Entamoeba histolytica protein kinase, putative 0.0039 0.0136 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.002 0.0013
Trypanosoma cruzi PH domain containing protein, putative 0.0039 0.0136 0.0357
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0039 0.0136 0.0357
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0155 0.0252
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0014
Brugia malayi Phospholipase D. Active site motif family protein 0.0808 0.3466 0.3461
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0155 0.3665
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0039 0.0136 0.0357
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0039 0.0136 0.0152
Leishmania major phosphoinositide-binding protein, putative 0.0101 0.0403 0.1928
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.002 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0055 0.1087
Brugia malayi beta-lactamase family protein 0.0043 0.0155 0.0148
Brugia malayi TRAF4-associated factor 2 0.0101 0.0403 0.0396
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0039 0.0136 0.079
Schistosoma mansoni growth factor receptor-bound protein 0.0039 0.0136 0.0136
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0155 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0136 0.3158
Schistosoma mansoni gabp alpha 0.0082 0.0322 0.0322
Echinococcus granulosus calcium dependent secretion activator 1 0.0039 0.0136 0.0136
Leishmania major cardiolipin synthetase, putative 0.0371 0.1574 0.8414
Entamoeba histolytica protein kinase, putative 0.0039 0.0136 0.0123
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0014
Echinococcus multilocularis cathepsin L 0.001 0.0012 0.0012
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0012 0.0012
Loa Loa (eye worm) fli-1 protein 0.0249 0.1044 0.1236
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.002 0.002
Onchocerca volvulus 0.002 0.0055 0.0189
Echinococcus granulosus pdz domain containing protein 0.0039 0.0136 0.0136
Brugia malayi PH domain containing protein 0.0039 0.0136 0.0128
Leishmania major hypothetical protein, conserved 0.0039 0.0136 0.0448
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0021
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0021
Brugia malayi Variant SH3 domain containing protein 0.0039 0.0136 0.0128
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0012 0.0012
Trypanosoma brucei cardiolipin synthetase, putative 0.0808 0.3466 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0155 0.0414
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0301 0.0835
Echinococcus multilocularis Pleckstrin y 0.0039 0.0136 0.0136
Brugia malayi beta-lactamase 0.0043 0.0155 0.0148
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0039 0.0136 0.0123
Entamoeba histolytica protein kinase, putative 0.0039 0.0136 0.0123
Schistosoma mansoni hypothetical protein 0.0012 0.0019 0.0019
Brugia malayi Oxysterol-binding protein 0.0039 0.0136 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0136 0.3158
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0039 0.0136 0.0123
Schistosoma mansoni phospholipase D 0.2318 1 1
Onchocerca volvulus 0.002 0.0055 0.0189
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.117 1
Trichomonas vaginalis alpha chimerin, putative 0.0039 0.0136 0.3158
Toxoplasma gondii phosphatidylinositol transfer protein 0.0039 0.0136 0.0237
Plasmodium falciparum oxysterol-binding protein, putative 0.0039 0.0136 0.079
Giardia lamblia hypothetical protein 0.0101 0.0403 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0055 0.0055
Schistosoma mansoni sorting nexin 0.0101 0.0403 0.0403
Echinococcus granulosus beta 1 syntrophin 0.0039 0.0136 0.0136
Entamoeba histolytica hypothetical protein 0.0101 0.0403 0.0391
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Onchocerca volvulus 0.0039 0.0136 0.0628
Echinococcus multilocularis ewsr:fli fusion protein type 0.0012 0.0019 0.0019
Echinococcus multilocularis oxysterol binding protein 3 0.0039 0.0136 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0055 0.1087
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Leishmania major protein kinase, putative 0.0039 0.0136 0.0448
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0039 0.0136 0.0123
Loa Loa (eye worm) PX domain-containing protein 0.0101 0.0403 0.0471
Trypanosoma cruzi cardiolipin synthetase, putative 0.0808 0.3466 1
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0039 0.0136 0.3158
Brugia malayi hypothetical protein 0.0286 0.1203 0.1197
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0012 0.0019 0.0019
Toxoplasma gondii phospholipase D active site domain-containing protein 0.0808 0.3466 1
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0039 0.0136 0.0136
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0039 0.0136 0.0357
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0136 0.3158
Schistosoma mansoni cpg binding protein 0.0032 0.0107 0.0107
Trichomonas vaginalis kinesin light chain, putative 0.0039 0.0136 0.3158
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0136 0.3158
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.002 0.002
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0039 0.0136 0.3158
Onchocerca volvulus 0.0039 0.0136 0.0628
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0019 0.0019
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0039 0.0136 0.0136
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0026 0.0018
Entamoeba histolytica PH domain containing protein 0.0039 0.0136 0.0123
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0039 0.0136 0.0136
Entamoeba histolytica protein kinase, putative 0.0039 0.0136 0.0123
Brugia malayi Cathepsin L-like precursor 0.0014 0.0026 0.0018
Entamoeba histolytica hypothetical protein 0.0039 0.0136 0.0123
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.002 0.002
Brugia malayi transcription factor E74 isoform 0.0012 0.0019 0.0011
Trypanosoma cruzi hypothetical protein 0.0039 0.0136 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0136 0.3158
Echinococcus granulosus myotubularin protein 13 0.0039 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0043 0.0155 0.0176
Entamoeba histolytica PH domain containing protein kinase, putative 0.0039 0.0136 0.0123
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0155 0.3665
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0055 0.0272
Echinococcus granulosus protein C ets 2 0.0012 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0136 0.3158
Onchocerca volvulus 0.002 0.0055 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0136 0.3158
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0403 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0056
Brugia malayi Dynamin 0.0039 0.0136 0.0128
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0055 0.1087
Trypanosoma cruzi hypothetical protein 0.0101 0.0403 0.1131
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0101 0.0403 0.0471
Brugia malayi Variant SH3 domain containing protein 0.0101 0.0403 0.0396
Echinococcus granulosus sorting nexin 0.0101 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0152
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0039 0.0136 0.0136
Plasmodium falciparum phosphatidylglycerophosphate synthase 0.0371 0.1574 1
Plasmodium vivax cardiolipin synthetase, putative 0.0371 0.1574 1
Brugia malayi PH domain containing protein 0.0039 0.0136 0.0128
Trypanosoma brucei rac serine-threonine kinase, putative 0.0039 0.0136 0.0357
Brugia malayi beta-lactamase family protein 0.0043 0.0155 0.0148
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0055 0.0055
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0039 0.0136 0.0357
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0039 0.0136 0.3158
Brugia malayi PXA domain containing protein 0.0101 0.0403 0.0396
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0148 0.3479
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0039 0.0136 0.079
Onchocerca volvulus Putative phospholipase D 0.0437 0.186 1
Loa Loa (eye worm) fibroinase 0.002 0.0055 0.0056
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.002 0.0013
Mycobacterium ulcerans hypothetical protein 0.0043 0.0155 1
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Entamoeba histolytica hypothetical protein 0.0101 0.0403 0.0391
Echinococcus multilocularis cytohesin 1 0.0039 0.0136 0.0136
Echinococcus granulosus DCC interacting protein 13 beta 0.0039 0.0136 0.0136
Entamoeba histolytica phospholipase D, putative 0.2318 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0152
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0217 0.0476
Loa Loa (eye worm) cytohesin 3 0.0039 0.0136 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0026 0.0346
Trypanosoma cruzi hypothetical protein 0.0039 0.0136 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0403 1
Onchocerca volvulus 0.0039 0.0136 0.0628
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1203 0.1203
Onchocerca volvulus 0.002 0.0055 0.0189
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0039 0.0136 0.0123
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0155 0.0148
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0012 0.0005
Loa Loa (eye worm) hypothetical protein 0.1946 0.8394 1
Echinococcus granulosus ewsr:fli fusion protein type 0.0012 0.0019 0.0019
Echinococcus granulosus Pleckstrin y 0.0039 0.0136 0.0136
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Echinococcus multilocularis Rho GTPase activating protein 24 0.0039 0.0136 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0055 0.1087
Echinococcus multilocularis dnaJ subfamily B 0.0434 0.1845 0.1845
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0055 0.1087
Trypanosoma cruzi hypothetical protein 0.0039 0.0136 0.0357
Trypanosoma cruzi PX domain containing protein, putative 0.0101 0.0403 0.1131
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.002 0.002
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0039 0.0136 0.079
Schistosoma mansoni serine/threonine-protein kinase 0.0039 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0043 0.0155 0.0176
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0148 0.3479
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0039 0.0136 0.3158
Brugia malayi steroid hormone receptor 0.0012 0.002 0.0013
Onchocerca volvulus 0.0043 0.0155 0.0736
Leishmania major protein kinase, putative 0.0039 0.0136 0.0448
Trypanosoma brucei phosphatidylglycerolphosphate synthase, mitochondrial 0.0371 0.1574 0.452
Echinococcus granulosus Phox 0.0101 0.0403 0.0403
Trichomonas vaginalis centaurin beta, putative 0.0039 0.0136 0.3158
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0393 0.0393
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0148 0.0274
Schistosoma mansoni thyroid hormone receptor 0.0012 0.002 0.002
Mycobacterium tuberculosis Conserved protein 0.0043 0.0155 0.0252
Schistosoma mansoni sortingnexin-related 0.0101 0.0403 0.0403
Echinococcus granulosus cysteine protease 0.001 0.0012 0.0012
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0148 0.0393
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0301 0.0835
Schistosoma mansoni dynamin 0.0039 0.0136 0.0136
Echinococcus multilocularis Pleckstrin y 0.0039 0.0136 0.0136
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0039 0.0136 0.0123
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0301 0.0835
Schistosoma mansoni sorting nexin 0.0101 0.0403 0.0403
Echinococcus granulosus ETS domain containing protein Elk 1 0.0012 0.0019 0.0019
Echinococcus granulosus oxysterol binding protein 1 0.0039 0.0136 0.0136
Echinococcus multilocularis nischarin 0.0101 0.0403 0.0403
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0039 0.0136 0.0357
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0247 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0136 0.3158
Chlamydia trachomatis phospholipase D superfamily protein 0.0371 0.1574 0.5
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0155 0.0252
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0155 0.0252
Trypanosoma cruzi hypothetical protein 0.0101 0.0403 0.1131
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0136 0.3158
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0403 1
Wolbachia endosymbiont of Brugia malayi cardiolipin synthase 0.0371 0.1574 1
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0039 0.0136 0.0152
Schistosoma mansoni goodpasture antigen-binding protein 0.0039 0.0136 0.0136
Entamoeba histolytica phospholipase D active site domain-containing protein 0.1946 0.8394 0.8392
Trypanosoma brucei cardiolipin synthetase 0.0808 0.3466 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0101 0.0403 0.0396
Plasmodium vivax vivapain-2 0.002 0.0055 0.0272
Loa Loa (eye worm) PXA domain-containing protein 0.0101 0.0403 0.0471
Onchocerca volvulus 0.003 0.0099 0.0429
Echinococcus multilocularis sorting nexin 0.0101 0.0403 0.0403
Leishmania major cathepsin L-like protease 0.0077 0.0301 0.1363
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0152
Loa Loa (eye worm) PH domain-containing protein 0.0039 0.0136 0.0152
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0014
Mycobacterium leprae Probable lipase LipE 0.0043 0.0155 1
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0039 0.0136 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0136 0.3158
Trypanosoma cruzi NIMA-related kinase, putative 0.0039 0.0136 0.0357
Loa Loa (eye worm) TRAF4-associated factor 2 0.0101 0.0403 0.0471
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0039 0.0136 0.0136
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0148 0.3479
Schistosoma mansoni ets-related 0.0249 0.1044 0.1044
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0039 0.0136 0.0136
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0039 0.0136 0.0136
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.002 0.002
Echinococcus multilocularis ETS transcription factor Elf 5 0.0012 0.0019 0.0019
Echinococcus granulosus sorting nexin 14 0.0101 0.0403 0.0403
Brugia malayi Fli-1 protein 0.0249 0.1044 0.1038
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0371 0.1574 0.5
Trypanosoma cruzi Autophagy-related protein 24 0.0101 0.0403 0.1131
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0055 0.1087
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.002 0.0013
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0039 0.0136 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0136 0.3158
Entamoeba histolytica PX domain protein 0.0101 0.0403 0.0391
Loa Loa (eye worm) hypothetical protein 0.0101 0.0403 0.0471
Loa Loa (eye worm) hypothetical protein 0.0043 0.0155 0.0176
Echinococcus granulosus serine/threonine protein kinase 0.0039 0.0136 0.0136
Brugia malayi hypothetical protein 0.0371 0.1574 0.1567
Loa Loa (eye worm) sorting nexin 12 0.0101 0.0403 0.0471
Brugia malayi Pleckstrin Homology Domain 0.0039 0.0136 0.0128
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0039 0.0136 0.0123
Schistosoma mansoni survival motor neuron protein 0.0058 0.0219 0.0219
Schistosoma mansoni rho gtpase activating protein 0.0039 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0152
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.002 0.002
Toxoplasma gondii ABC1 family protein 0.0043 0.0155 0.0295
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0039 0.0136 0.0128
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0082 0.0322 0.0374
Brugia malayi Inositol-1 0.0042 0.0148 0.0141
Loa Loa (eye worm) Plekhf2 protein 0.0039 0.0136 0.0152
Trypanosoma cruzi Protein kinase B 0.0039 0.0136 0.0357
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0148 0.0136
Schistosoma mansoni oxysterol-binding protein 1 0.0039 0.0136 0.0136
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0039 0.0136 0.0628
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0055 0.1087
Brugia malayi TBC domain containing protein 0.0039 0.0136 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.002 0.0013
Brugia malayi Uncoordinated protein 104 0.0039 0.0136 0.0128
Echinococcus granulosus cpg binding protein 0.0032 0.0107 0.0107
Loa Loa (eye worm) D-ets-2 protein 0.0012 0.0019 0.0013
Trichomonas vaginalis hypothetical protein 0.0039 0.0136 0.3158
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0136 0.3158
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0039 0.0136 0.0237
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0155 0.0414
Loa Loa (eye worm) uncoordinated protein 104 0.0039 0.0136 0.0152
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0148 0.0148
Entamoeba histolytica ARF GTPase activating protein, putative 0.0039 0.0136 0.0123
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0055 0.0055
Entamoeba histolytica cysteine protease, putative 0.002 0.0055 0.0042
Plasmodium vivax phosphatidylglycerophosphate synthase, putative 0.0371 0.1574 1
Toxoplasma gondii AtPH1 family protein 0.0039 0.0136 0.0237
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.002 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0301 0.0835
Brugia malayi Ets-domain containing protein 0.0082 0.0322 0.0315
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.002 0.002
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0039 0.0136 0.0448
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.002 0.002
Trichomonas vaginalis esterase, putative 0.0043 0.0155 0.3665
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0152
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Echinococcus multilocularis sorting nexin 14 0.0101 0.0403 0.0403
Schistosoma mansoni zinc finger protein 0.0039 0.0136 0.0136
Onchocerca volvulus Putative zinc finger protein 0.0039 0.0136 0.0628
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0301 0.0835
Schistosoma mansoni cpg binding protein 0.003 0.0099 0.0099
Echinococcus multilocularis Oxysterol binding protein 11 0.0039 0.0136 0.0136
Schistosoma mansoni cpg binding protein 0.0032 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0101 0.0403 0.0471
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0152
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.002 0.0013
Brugia malayi Variant SH3 domain containing protein 0.0039 0.0136 0.0128
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0012 0.0019 0.0013
Onchocerca volvulus 0.0101 0.0403 0.208
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0026 0.0026
Loa Loa (eye worm) oxysterol binding protein 0.0039 0.0136 0.0152
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0136 0.079
Echinococcus granulosus Rho GTPase activating protein 24 0.0039 0.0136 0.0136
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0393 0.0393
Echinococcus multilocularis cysteine protease 0.002 0.0055 0.0055
Leishmania major cathepsin L-like protease 0.0077 0.0301 0.1363
Onchocerca volvulus Cathepsin L homolog 0.002 0.0055 0.0189
Schistosoma mansoni elf1 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0371 0.1574 0.1867
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0055 0.1087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.002 0.0014
Echinococcus multilocularis beta 1 syntrophin 0.0039 0.0136 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.002 0.0013
Onchocerca volvulus 0.0039 0.0136 0.0628
Echinococcus multilocularis Ras associated and pleckstrin y 0.0039 0.0136 0.0136
Loa Loa (eye worm) AGC/AKT protein kinase 0.0039 0.0136 0.0152
Toxoplasma gondii protein kinase domain-containing protein 0.0039 0.0136 0.0237
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0055 0.1087
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.002 0.002
Toxoplasma gondii hypothetical protein 0.0101 0.0403 0.102
Schistosoma mansoni serine/threonine-protein kinase 0.0039 0.0136 0.0136
Schistosoma mansoni hypothetical protein 0.0039 0.0136 0.0136
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0012 0.0019 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0393 0.0393
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0055 0.1087
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0152
Echinococcus granulosus dynamin 1 0.0039 0.0136 0.0136
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.1946 0.8394 1
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0055 0.0047
Echinococcus multilocularis oxysterol binding protein 1 0.0039 0.0136 0.0136
Trypanosoma cruzi Autophagy-related protein 24 0.0101 0.0403 0.1131
Echinococcus multilocularis Pleckstrin y 0.0039 0.0136 0.0136
Toxoplasma gondii hypothetical protein 0.0039 0.0136 0.0237
Entamoeba histolytica PH domain containing protein kinase, putative 0.0039 0.0136 0.0123
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0155 0.0176
Schistosoma mansoni ets 0.0012 0.0019 0.0019
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Echinococcus multilocularis pleckstrin y domain containing family A 0.0039 0.0136 0.0136
Echinococcus multilocularis cpg binding protein 0.0032 0.0107 0.0107
Brugia malayi Oxysterol binding protein 0.0039 0.0136 0.0128
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0039 0.0136 0.0357
Entamoeba histolytica protein kinase, putative 0.0039 0.0136 0.0123
Onchocerca volvulus outspread protein homolog 0.0039 0.0136 0.0628
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0393 0.0393
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0019 0.0019
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0301 0.0835
Trichomonas vaginalis centaurin/arf, putative 0.0039 0.0136 0.3158
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0039 0.0136 0.3158
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0055 0.0056
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0371 0.1574 0.5
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0039 0.0136 0.0628
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.002 0.002
Brugia malayi Cathepsin L-like precursor 0.002 0.0055 0.0047
Trichomonas vaginalis protein transport protein sec7, putative 0.0039 0.0136 0.3158
Echinococcus granulosus GRB2 associated binding protein 3 0.0039 0.0136 0.0136
Echinococcus granulosus ETS transcription factor Elf 5 0.0012 0.0019 0.0019
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0148 0.0518
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0055 0.0055
Echinococcus granulosus phospholipase d3 0.0437 0.186 0.186
Brugia malayi Sorting nexin 12 0.0101 0.0403 0.0396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0055 0.1087
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0155 0.0155
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0039 0.0136 0.0357
Echinococcus granulosus Oxysterol binding protein 11 0.0039 0.0136 0.0136
Plasmodium falciparum phosphoinositide-binding protein, putative 0.0101 0.0403 0.2501
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0055 0.1087
Schistosoma mansoni myotubularin-related protein 0.0039 0.0136 0.0136
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0155 0.0252
Entamoeba histolytica protein kinase, putative 0.0039 0.0136 0.0123
Schistosoma mansoni inositol monophosphatase 0.0042 0.0148 0.0148
Schistosoma mansoni ets-related 0.0012 0.0019 0.0019
Echinococcus multilocularis ETS transcription factor Elf 1 0.0012 0.0019 0.0019
Brugia malayi DNA-binding protein D-ETS-3 0.0012 0.0019 0.0011
Schistosoma mansoni hypothetical protein 0.0434 0.1845 0.1845
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0039 0.0136 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0403 1
Schistosoma mansoni dynamin 0.0039 0.0136 0.0136
Schistosoma mansoni centaurin alpha 0.0039 0.0136 0.0136
Giardia lamblia Hypothetical protein 0.0101 0.0403 0.5
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.002 0.002
Brugia malayi Cathepsin L-like precursor 0.002 0.0055 0.0047
Giardia lamblia Liver stage antigen-like protein 0.0101 0.0403 0.5
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0148 0.0393
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0393 0.0386
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0012 0.0005
Trypanosoma cruzi PH domain containing protein, putative 0.0039 0.0136 0.0357
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0055 0.0055
Trichomonas vaginalis protein transport protein sec7, putative 0.0039 0.0136 0.3158
Onchocerca volvulus 0.0043 0.0155 0.0736
Echinococcus multilocularis rac serine:threonine kinase 0.0039 0.0136 0.0136
Echinococcus granulosus nischarin 0.0101 0.0403 0.0403
Onchocerca volvulus 0.002 0.0055 0.0189
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0014
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Brugia malayi Cathepsin L-like precursor 0.002 0.0055 0.0047
Trypanosoma cruzi hypothetical protein 0.0101 0.0403 0.1131
Brugia malayi Cytohesin 3 0.0039 0.0136 0.0128
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0039 0.0136 0.0123
Plasmodium falciparum phosphoinositide-binding protein, putative 0.0101 0.0403 0.2501
Brugia malayi Protein K4 0.0371 0.1574 0.1567
Schistosoma mansoni zinc finger protein 0.0039 0.0136 0.0136
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0039 0.0136 0.0136
Brugia malayi PX domain containing protein 0.0101 0.0403 0.0396
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0393 0.0393
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0152
Plasmodium vivax PH domain containing protein 0.0039 0.0136 0.079
Brugia malayi cathepsin L-like precursor 0.0014 0.0026 0.0018
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0012 0.0012
Brugia malayi PH domain containing protein 0.0039 0.0136 0.0128
Echinococcus granulosus Pleckstrin y 0.0039 0.0136 0.0136
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0155 0.0252
Echinococcus granulosus sorting nexin 2 0.0101 0.0403 0.0403
Echinococcus granulosus cytohesin 1 0.0039 0.0136 0.0136
Echinococcus multilocularis myotubularin protein 13 0.0039 0.0136 0.0136
Echinococcus granulosus oxysterol binding protein 9 0.0039 0.0136 0.0136
Echinococcus multilocularis pdz domain containing protein 0.0039 0.0136 0.0136
Echinococcus granulosus phospholipase D 0.2047 0.8829 0.8829
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.002 0.0014
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.002 0.002
Onchocerca volvulus Cathepsin L homolog 0.002 0.0055 0.0189
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0055 0.1087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0301 0.0835
Entamoeba histolytica PH domain containing protein 0.0039 0.0136 0.0123
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0039 0.0136 0.0123
Echinococcus multilocularis Phox 0.0101 0.0403 0.0403
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0039 0.0136 0.0128
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0055 0.1087
Mycobacterium tuberculosis Conserved protein 0.0043 0.0155 0.0252
Schistosoma mansoni hypothetical protein 0.0058 0.0219 0.0219
Entamoeba histolytica hypothetical protein 0.0039 0.0136 0.0123
Brugia malayi Plekhf2 protein 0.0039 0.0136 0.0128
Schistosoma mansoni thyroid hormone receptor 0.0012 0.002 0.002
Trypanosoma brucei differentiation inhibitory kinase 0.0101 0.0403 0.1131
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0013
Trypanosoma brucei protein kinase, putative 0.0039 0.0136 0.0357
Leishmania major hypothetical protein, conserved 0.0039 0.0136 0.0448
Brugia malayi PX domain containing protein 0.0101 0.0403 0.0396
Leishmania major cathepsin L-like protease 0.0077 0.0301 0.1363
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0014
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0155 0.3665
Entamoeba histolytica hypothetical protein 0.014 0.0571 0.056
Echinococcus multilocularis sorting nexin 6 0.0101 0.0403 0.0403
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.002 0.002
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.002 0.0014
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.002 0.002
Onchocerca volvulus 0.002 0.0055 0.0189
Loa Loa (eye worm) PX domain-containing protein 0.0101 0.0403 0.0471
Loa Loa (eye worm) hypothetical protein 0.0101 0.0403 0.0471
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.002 0.0013
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0055 0.0272
Trypanosoma cruzi PX domain containing protein, putative 0.0101 0.0403 0.1131
Trypanosoma brucei PH domain containing protein, putative 0.0039 0.0136 0.0357
Entamoeba histolytica protein kinase, putative 0.0039 0.0136 0.0123
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0039 0.0136 0.0123
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0286 0.1203 0.1426
Plasmodium falciparum mitochondrial cardiolipin synthase, putative 0.0371 0.1574 1
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0039 0.0136 0.3158
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Echinococcus granulosus sorting nexin 4 0.0101 0.0403 0.0403
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0371 0.1574 0.5
Entamoeba histolytica phospholipase D, putative 0.2318 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0155 0.0155
Echinococcus multilocularis protein C ets 2 0.0012 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0136 0.3158
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0055 0.1087
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0039 0.0136 0.0136
Schistosoma mansoni hypothetical protein 0.0039 0.0136 0.0136
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0039 0.0136 0.0136
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0039 0.0136 0.079
Trypanosoma cruzi PH domain containing protein, putative 0.0039 0.0136 0.0357
Entamoeba histolytica hypothetical protein 0.0039 0.0136 0.0123
Loa Loa (eye worm) hypothetical protein 0.0101 0.0403 0.0471
Brugia malayi PH domain containing protein 0.0039 0.0136 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0403 1
Loa Loa (eye worm) syntrophin-1 0.0039 0.0136 0.0152
Echinococcus multilocularis cysteine protease 0.002 0.0055 0.0055
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0008 0.0008
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0039 0.0136 0.0136
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0039 0.0136 0.0136
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0155 1
Schistosoma mansoni coup transcription factor 0.0012 0.002 0.002
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0155 0.0917
Plasmodium vivax hypothetical protein, conserved 0.0101 0.0403 0.2501
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Brugia malayi probable spectrin beta chain 0.0039 0.0136 0.0128
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0039 0.0136 0.0152
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0152
Schistosoma mansoni goodpasture antigen-binding protein 0.0039 0.0136 0.0136
Schistosoma mansoni hypothetical protein 0.0039 0.0136 0.0136
Schistosoma mansoni oxysterol-binding protein 1 0.0039 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0013
Trypanosoma cruzi hypothetical protein 0.0039 0.0136 0.0357
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0055 0.0055
Brugia malayi nuclear hormone receptor 0.0012 0.002 0.0013
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0393 0.046
Trypanosoma cruzi hypothetical protein 0.0039 0.0136 0.0357
Toxoplasma gondii hypothetical protein 0.0039 0.0136 0.0237
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0152
Loa Loa (eye worm) hypothetical protein 0.1509 0.6501 0.7743
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0403 1
Loa Loa (eye worm) ets-domain-containing protein 0.0012 0.0019 0.0013
Trypanosoma cruzi NIMA-related kinase, putative 0.0039 0.0136 0.0357
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Echinococcus multilocularis sorting nexin 2 0.0101 0.0403 0.0403
Echinococcus granulosus sorting nexin 13 0.0101 0.0403 0.0403
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0055 0.1087
Trypanosoma cruzi PX domain containing protein, putative 0.0101 0.0403 0.1131
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0039 0.0136 0.0357
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.002 0.0013
Loa Loa (eye worm) inositol-1 0.0042 0.0148 0.0167
Mycobacterium tuberculosis Conserved protein 0.0043 0.0155 0.0252
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0155 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0055 0.0047
Mycobacterium ulcerans lipase LipD 0.0043 0.0155 1
Brugia malayi Ets-domain containing protein 0.0082 0.0322 0.0315
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0055 0.1087
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1203 0.1203
Leishmania major hypothetical protein, conserved 0.0043 0.0155 0.0558
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0152
Onchocerca volvulus 0.0101 0.0403 0.208
Entamoeba histolytica PH domain containing protein kinase, putative 0.0039 0.0136 0.0123
Trypanosoma brucei Autophagy-related protein 24 0.0101 0.0403 0.1131
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0136 0.3158
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.002 0.0013
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0055 0.0272
Entamoeba histolytica PH domain containing protein 0.0039 0.0136 0.0123
Loa Loa (eye worm) cysteine protease 0.002 0.0055 0.0056
Onchocerca volvulus 0.0043 0.0155 0.0736
Onchocerca volvulus Protein melted homolog 0.0039 0.0136 0.0628
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0055 0.0042
Echinococcus granulosus oxysterol binding protein 3 0.0039 0.0136 0.0136
Brugia malayi PX domain containing protein 0.0101 0.0403 0.0396
Chlamydia trachomatis phospholipase D endonuclease family protein 0.0371 0.1574 0.5
Echinococcus multilocularis ets variant gene 4 0.0012 0.0019 0.0019
Echinococcus granulosus cathepsin l1 0.0014 0.0026 0.0026
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0039 0.0136 0.079
Schistosoma mansoni hypothetical protein 0.0039 0.0136 0.0136
Leishmania major zinc finger protein kinase-like 0.0101 0.0403 0.1928
Entamoeba histolytica hypothetical protein 0.0039 0.0136 0.0123
Brugia malayi Cadps2 protein 0.0039 0.0136 0.0128
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0039 0.0136 0.0357
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0055 0.0056
Onchocerca volvulus 0.0039 0.0136 0.0628
Plasmodium falciparum PH domain-containing protein, putative 0.0039 0.0136 0.079
Loa Loa (eye worm) hypothetical protein 0.0043 0.0155 0.0176
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0039 0.0136 0.0136
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0055 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0055 0.1087
Entamoeba histolytica hypothetical protein, conserved 0.0039 0.0136 0.0123
Echinococcus granulosus ribosomal protein S6 kinase delta 1 0.0101 0.0403 0.0403
Giardia lamblia Hypothetical protein 0.0101 0.0403 0.5
Leishmania major folate/biopterin transporter, putative 0.0039 0.0136 0.0448
Echinococcus multilocularis ribosomal protein S6 kinase delta 1 0.0101 0.0403 0.0403
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0148 0.0393
Plasmodium vivax WD domain, G-beta repeat domain containing protein 0.0101 0.0403 0.2501
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.002 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0155 0.0414
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0152
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0155 0.0176
Onchocerca volvulus 0.002 0.0055 0.0189
Schistosoma mansoni inositol monophosphatase 0.0042 0.0148 0.0148
Onchocerca volvulus 0.0058 0.0219 0.1083
Brugia malayi MAX-1A 0.0039 0.0136 0.0128
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0039 0.0136 0.0357
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0301 0.0835
Trichomonas vaginalis centaurin gamma, putative 0.0039 0.0136 0.3158
Loa Loa (eye worm) phospholipase D 0.0437 0.186 0.2208
Trypanosoma cruzi PH domain containing protein, putative 0.0039 0.0136 0.0357
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0301 0.0835
Entamoeba histolytica PH domain containing protein kinase, putative 0.0039 0.0136 0.0123
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.002 0.002
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0155 0.0252
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0039 0.0136 0.0357
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0039 0.0136 0.0357
Plasmodium falciparum calcium-dependent protein kinase 7 0.0039 0.0136 0.079
Brugia malayi Ets-domain containing protein 0.0012 0.0019 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0055 0.1087
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0152
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0219 0.0212
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0272 0.0751
Echinococcus multilocularis calcium dependent secretion activator 1 0.0039 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0021
Loa Loa (eye worm) ctsf protein 0.002 0.0055 0.0056
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0136 0.3158
Brugia malayi hypothetical protein 0.0039 0.0136 0.0128
Leishmania major phosphatidylglycerophosphate synthase, putative 0.0437 0.186 1
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0039 0.0136 0.079
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0152
Echinococcus granulosus Pleckstrin y 0.0039 0.0136 0.0136
Brugia malayi PH domain containing protein 0.0039 0.0136 0.0128
Schistosoma mansoni hypothetical protein 0.0039 0.0136 0.0136
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0155 0.3665
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0101 0.0403 0.102
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0301 0.0835
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0012 0.0012
Brugia malayi Cathepsin L-like precursor 0.0014 0.0026 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0136 0.3158
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.002 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0055 0.1087
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.0152

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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