Detailed information for compound 1001143

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 368.809 | Formula: C18H21ClO6
  • H donors: 2 H acceptors: 4 LogP: 3.28 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H]1C[C@H]2O[C@@H]2CCCCC(=O)Cc2c(C(=O)O1)c(O)cc(c2Cl)O
  • InChi: 1S/C18H21ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h8-9,14-15,21-22H,2-7H2,1H3/t9-,14-,15-/m1/s1
  • InChiKey: ZGZOBNGYHLFQFW-DFKRKDTASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein-tyrosine phosphatase 1 0.0231 0.0413 0.0413
Echinococcus multilocularis transferase 0.0074 0.0118 0.0116
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0242 0.0432 0.043
Loa Loa (eye worm) hypothetical protein 0.0145 0.025 0.025
Loa Loa (eye worm) cytochrome P450 0.0035 0.0044 0.0044
Leishmania major DNA polymerase eta, putative 0.0063 0.0096 0.0918
Echinococcus granulosus single minded 2 0.0036 0.0046 0.0044
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0145 0.0145
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0231 0.0413 0.0413
Brugia malayi cytochrome P450 0.0035 0.0044 0.0044
Mycobacterium ulcerans hypothetical protein 0.0074 0.0118 0.0342
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0029 0.0029
Echinococcus granulosus Endonuclease G 0.0284 0.0512 0.0511
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0473 0.0867 0.0866
Brugia malayi hypothetical protein 0.0163 0.0285 0.0285
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0049 0.0468
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.009 0.1763
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Brugia malayi hypothetical protein 0.0231 0.0413 0.0413
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0231 0.0413 0.0413
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0231 0.0413 0.0411
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0003 0.0025
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0473 0.0867 0.0866
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.009 0.009
Brugia malayi hypothetical protein 0.0231 0.0413 0.0413
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0231 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Schistosoma mansoni lamin 0.0027 0.0029 0.0029
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0035 0.0044 0.0417
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0231 0.0413 0.0411
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0231 0.0413 0.0411
Onchocerca volvulus 0.0231 0.0413 0.1193
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0231 0.0413 0.0411
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0035 0.0044 0.0127
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0231 0.0413 0.0411
Loa Loa (eye worm) protein tyrosine phosphatase 0.0231 0.0413 0.0413
Schistosoma mansoni protein tyrosine phosphatase 0.0242 0.0432 0.0432
Echinococcus granulosus Polycystic kidney disease protein 0.006 0.009 0.0088
Echinococcus granulosus lipoxygenase domain containing protein 0.006 0.009 0.0088
Echinococcus granulosus lamin 0.0027 0.0029 0.0027
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0049 0.0137
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0035 0.0044 0.0127
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0231 0.0413 0.0411
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0242 0.0432 0.043
Onchocerca volvulus 0.006 0.009 0.0256
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.009 0.0262
Brugia malayi Thrombospondin type 1 domain containing protein 0.1022 0.1898 0.1898
Mycobacterium leprae Conserved hypothetical protein 0.0035 0.0044 0.1764
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0047 0.045
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0052 0.0076 0.0221
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0231 0.0413 0.0411
Brugia malayi AEL166Cp 0.0074 0.0118 0.0118
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0045 0.0045
Onchocerca volvulus 0.0231 0.0413 0.1193
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0035 0.0044 0.0127
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0045 0.0429
Trypanosoma cruzi cytochrome P450, putative 0.0052 0.0076 0.0727
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0035 0.0044 0.0127
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Brugia malayi intermediate filament protein 0.0027 0.0029 0.0029
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0284 0.0512 0.4893
Echinococcus granulosus gpi ethanolamine phosphate transferase 3 0.0074 0.0118 0.0116
Leishmania major tyrosine specific protein phosphatase, putative 0.0231 0.0413 0.394
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0231 0.0413 0.394
Brugia malayi hypothetical protein 0.0231 0.0413 0.0413
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0049 0.0049
Echinococcus granulosus protein tyrosine phosphatase n9 0.0231 0.0413 0.0411
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0045 0.0122
Schistosoma mansoni hypothetical protein 0.1022 0.1898 0.1898
Leishmania major protein kinase, putative 0.0061 0.0092 0.0876
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0231 0.0413 0.0411
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.0513 0.1481
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0045 0.0125
Onchocerca volvulus 0.0231 0.0413 0.1193
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0242 0.0432 0.043
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0231 0.0413 0.0413
Leishmania major cytochrome p450-like protein 0.0035 0.0044 0.0417
Loa Loa (eye worm) hypothetical protein 0.0074 0.0118 0.0118
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0231 0.0413 0.0411
Loa Loa (eye worm) hypothetical protein 0.0473 0.0867 0.0867
Echinococcus granulosus ectonucleotide 0.0399 0.0727 0.0726
Loa Loa (eye worm) hypothetical protein 0.006 0.009 0.009
Echinococcus multilocularis hypothetical protein 0.0231 0.0413 0.0411
Mycobacterium leprae putative cytochrome p450 0.0035 0.0044 0.1764
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0391 0.0713 0.0713
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Echinococcus granulosus cpg binding protein 0.003 0.0034 0.0032
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0049 0.0468
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0231 0.0413 0.0411
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0231 0.0413 0.394
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0231 0.0413 0.0411
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0513 0.1484
Echinococcus multilocularis 0.0035 0.0044 0.0042
Schistosoma mansoni alpha-glucosidase 0.0138 0.0237 0.0237
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.0239 1
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0231 0.0413 0.0411
Echinococcus granulosus lamin dm0 0.0027 0.0029 0.0027
Loa Loa (eye worm) CYP4Cod1 0.0052 0.0076 0.0076
Echinococcus granulosus intermediate filament protein 0.0027 0.0029 0.0027
Trypanosoma cruzi endonuclease G, putative 0.0284 0.0512 0.4893
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0027 0.0257
Onchocerca volvulus 0.0231 0.0413 0.1193
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0074 0.0118 0.0116
Schistosoma mansoni lamin 0.0027 0.0029 0.0029
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0061 0.0092 0.0876
Onchocerca volvulus 0.1846 0.3446 1
Schistosoma mansoni hypothetical protein 0.0074 0.0118 0.0118
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0049 0.0142
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.1846 0.3446 1
Echinococcus multilocularis geminin 0.0345 0.0626 0.0624
Schistosoma mansoni hypothetical protein 0.0035 0.0044 0.0044
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0035 0.0044 0.0127
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0074 0.0118 0.0116
Trypanosoma brucei cytochrome P450, putative 0.0052 0.0076 0.0727
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0046 0.0046
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0047 0.092
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0045 0.0125
Brugia malayi hypothetical protein 0.0231 0.0413 0.0413
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0242 0.0432 0.0432
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.009 0.009
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0045 0.0045
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0284 0.0512 0.4893
Leishmania major cytochrome p450-like protein 0.0052 0.0076 0.0727
Onchocerca volvulus GPI ethanolamine phosphate transferase 2 homolog 0.0074 0.0118 0.0337
Plasmodium falciparum protein serine/threonine kinase-1 0.0061 0.0092 0.7785
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0231 0.0413 0.394
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0003 0.0003
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0035 0.0044 0.0127
Schistosoma mansoni alpha glucosidase 0.0036 0.0045 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0027 0.0257
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0045 0.0043
Echinococcus multilocularis musashi 0.0027 0.0029 0.0027
Schistosoma mansoni lipoxygenase 0.0249 0.0447 0.0447
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0049 0.0047
Echinococcus multilocularis ectonucleotide 0.0399 0.0727 0.0726
Echinococcus granulosus neuropeptide s receptor 0.0485 0.089 0.0888
Loa Loa (eye worm) protein-tyrosine phosphatase 0.5334 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.016 0.0278 0.0278
Leishmania major ethanolamine phosphotransferase, putative 0.0074 0.0118 0.1125
Onchocerca volvulus 0.0231 0.0413 0.1193
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0473 0.0867 0.0866
Brugia malayi Muscleblind-like protein 0.0145 0.025 0.025
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0473 0.0867 0.0866
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.0279 0.0279
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0242 0.0432 0.043
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0035 0.0044 0.0127
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0045 0.0122
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0231 0.0413 0.0413
Onchocerca volvulus 0.1022 0.1898 0.5505
Trypanosoma cruzi DNA polymerase eta, putative 0.0063 0.0096 0.0918
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0473 0.0867 0.0866
Trypanosoma brucei unspecified product 0.0026 0.0027 0.0257
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0074 0.0118 0.0337
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0231 0.0413 0.0413
Echinococcus granulosus dna polymerase eta 0.0063 0.0096 0.0094
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0231 0.0413 0.0413
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0231 0.0413 0.0413
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 homolog 0.0074 0.0118 0.0337
Schistosoma mansoni rab6-interacting 0.006 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.006 0.0091 0.0091
Onchocerca volvulus 0.0231 0.0413 0.1193
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0145 0.0143
Plasmodium vivax serine/threonine kinase-1, putative 0.0061 0.0092 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0002 0.0017
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0049 0.0049
Brugia malayi Cytochrome P450 family protein 0.0035 0.0044 0.0044
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0029 0.0029
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0078 0.1513
Entamoeba histolytica protein tyrosine phosphatase, putative 0.1846 0.3446 1
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0074 0.0118 0.0116
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0092 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0049 0.0468
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0049 0.0468
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Brugia malayi hypoxia-induced factor 1 0.0151 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Brugia malayi Doublecortin family protein 0.006 0.009 0.009
Leishmania major DNA polymerase eta, putative 0.0037 0.0047 0.045
Onchocerca volvulus 0.0027 0.0029 0.0078
Giardia lamblia Protein tyrosine phosphatase 0.0231 0.0413 0.1197
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0049 0.0023
Onchocerca volvulus GPI ethanolamine phosphate transferase 3 homolog 0.0074 0.0118 0.0337
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0473 0.0867 0.0866
Brugia malayi Protein-tyrosine phosphatase 0.0401 0.0732 0.0732
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Onchocerca volvulus 0.017 0.0298 0.0859
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0231 0.0413 0.119
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0049 0.0468
Loa Loa (eye worm) hypothetical protein 0.0163 0.0285 0.0285
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0061 0.0092 0.0876
Echinococcus granulosus geminin 0.0345 0.0626 0.0624
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0231 0.0413 0.0411
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0035 0.0044 0.0127
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0513 0.1484
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0049 0.0468
Schistosoma mansoni hypothetical protein 0.0345 0.0626 0.0626
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0049 0.0468
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Onchocerca volvulus 0.0231 0.0413 0.1193
Loa Loa (eye worm) hypothetical protein 0.016 0.0278 0.0278
Trypanosoma cruzi hypothetical protein, conserved 0.0569 0.1047 1
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0002 0.5
Echinococcus multilocularis RUN 0.006 0.009 0.0088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0145 0.0143
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0035 0.0044 0.0127
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0231 0.0413 0.0413
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0046 0.0044
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Onchocerca volvulus 0.0231 0.0413 0.1193
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0049 0.0023
Brugia malayi hypothetical protein 0.0074 0.0118 0.0118
Brugia malayi hypothetical protein 0.006 0.009 0.009
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0045 0.0876
Trypanosoma brucei DNA polymerase eta, putative 0.0063 0.0096 0.0918
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0049 0.0468
Onchocerca volvulus 0.0231 0.0413 0.1193
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0049 0.0049
Schistosoma mansoni single-minded 0.0049 0.0069 0.0069
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0231 0.0413 0.0413
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0231 0.0413 0.0411
Schistosoma mansoni protein tyrosine phosphatase 0.0231 0.0413 0.0413
Onchocerca volvulus 0.0231 0.0413 0.1193
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0473 0.0867 0.0867
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0003 0.0027
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0242 0.0432 0.0432
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0513 0.1484
Onchocerca volvulus 0.0473 0.0867 0.2513
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0473 0.0867 0.0867
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0231 0.0413 0.0413
Plasmodium vivax multidomain scavenger receptor, putative 0.006 0.009 0.9812
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.0279 0.0278
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0045 0.0125
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0003 0.0003
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0231 0.0413 0.394
Onchocerca volvulus 0.0473 0.0867 0.2513
Trypanosoma brucei glucosidase, putative 0.0036 0.0045 0.0429
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0074 0.0118 0.0118
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.009 0.0089
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.009 0.0863
Brugia malayi Cytochrome P450 family protein 0.011 0.0185 0.0185
Onchocerca volvulus 4.1 G protein, putative homolog 0.0231 0.0413 0.1193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0145 0.0145
Brugia malayi endonuclease G, mitochondrial precursor 0.0284 0.0512 0.0512
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0145 0.0143
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0045 0.0125
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0049 0.0142
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0242 0.0432 0.043
Schistosoma mansoni polycystin 1-related 0.006 0.009 0.009
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0061 0.0092 0.0876
Schistosoma mansoni hypothetical protein 0.0074 0.0118 0.0118
Echinococcus granulosus lipoxygenase domain containing protein 0.006 0.009 0.0088
Echinococcus granulosus RUN 0.006 0.009 0.0088
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Trypanosoma brucei unspecified product 0.0026 0.0027 0.0257
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0049 0.0047
Schistosoma mansoni alpha-glucosidase 0.0138 0.0237 0.0237
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0231 0.0413 0.0411
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0569 0.1047 1
Echinococcus multilocularis 0.0231 0.0413 0.0411
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0242 0.0432 0.043
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0074 0.0118 0.0334
Echinococcus granulosus dna polymerase kappa 0.0038 0.0049 0.0047
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Brugia malayi Cytochrome P450 family protein 0.0052 0.0076 0.0076
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0231 0.0413 0.0411
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0089 0.0089
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0231 0.0413 0.0413
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0231 0.0413 0.0411
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0074 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0003 0.0003
Mycobacterium leprae hypothetical protein 0.0074 0.0118 0.4889
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0002 0.0017
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0003 0.0025
Echinococcus multilocularis neuropeptide s receptor 0.0485 0.089 0.0888
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0049 0.0468
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0231 0.0413 0.0413
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0231 0.0413 0.119
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0045 0.0125
Leishmania major protein kinase, putative 0.0013 0.0003 0.0025
Echinococcus multilocularis gpi ethanolamine phosphate transferase 1 0.0074 0.0118 0.0116
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0049 0.0047
Brugia malayi hypothetical protein 0.0074 0.0118 0.0118
Onchocerca volvulus 0.0231 0.0413 0.1193
Onchocerca volvulus 0.0231 0.0413 0.1193
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.0279 0.0278
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0035 0.0044 0.0417
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0231 0.0413 0.0411
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0049 0.0468
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0003 0.0003
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Echinococcus multilocularis Alkaline phosphatase, core domain 0.0074 0.0118 0.0116
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0569 0.1047 0.3035
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0035 0.0044 0.0127
Onchocerca volvulus 0.0231 0.0413 0.1193
Entamoeba histolytica protein tyrosine phosphatase, putative 0.1846 0.3446 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0029 0.0029
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0473 0.0867 0.0866
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0061 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0003 0.0003
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.5334 1 1
Plasmodium falciparum LCCL domain-containing protein 0.006 0.009 0.7639
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Brugia malayi Cytochrome P450 family protein 0.0052 0.0076 0.0076
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0045 0.0125
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0513 0.1484
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.009 0.0089
Onchocerca volvulus 0.0231 0.0413 0.1193
Onchocerca volvulus 0.006 0.009 0.0256
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0074 0.0118 0.0118
Loa Loa (eye worm) hypoxia-induced factor 1 0.0151 0.0261 0.0261
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0242 0.0432 0.0432
Brugia malayi hypothetical protein 0.0231 0.0413 0.0413
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0045 0.0125
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0569 0.1047 0.3035
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0003 0.0027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0513 0.1484
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0231 0.0413 0.0411
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0049 0.0134
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.1846 0.3446 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1846 0.3446 1
Trypanosoma brucei endonuclease G, putative 0.0284 0.0512 0.4893
Trypanosoma cruzi endonuclease G, putative 0.0284 0.0512 0.4893
Schistosoma mansoni protein tyrosine phosphatase 0.0231 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.006 0.009 0.009
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0242 0.0432 0.0432
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0473 0.0867 0.0867
Loa Loa (eye worm) hypothetical protein 0.0074 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0231 0.0413 0.0411
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0231 0.0413 0.0411
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.0239 0.0694
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0035 0.0044 0.0127
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Onchocerca volvulus 0.0093 0.0152 0.0437
Onchocerca volvulus 0.0231 0.0413 0.1193
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0473 0.0867 0.0867
Schistosoma mansoni cpg binding protein 0.003 0.0034 0.0034
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0231 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Onchocerca volvulus 0.0231 0.0413 0.1193
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0231 0.0413 0.0413
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0045 0.0429
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0061 0.0092 0.1791
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 7 homolog 0.0074 0.0118 0.0337
Trichomonas vaginalis pten, drome, putative 0.0231 0.0413 0.1193
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0357 0.0648 0.0647
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0473 0.0867 0.0866
Treponema pallidum fructose-bisphosphate aldolase 0.0285 0.0513 0.5
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0231 0.0413 0.0411
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0473 0.0867 0.0867
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.1846 0.3446 0.3446
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0049 0.0468
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0035 0.0044 0.0127
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0045 0.0043
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0231 0.0413 0.0411
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0242 0.0432 0.043
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.1277 0.2377 1
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0092 0.0261
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.0096 0.0096
Loa Loa (eye worm) type I phosphodiesterase/nucleotide pyrophosphatase 0.0074 0.0118 0.0118
Loa Loa (eye worm) cytochrome P450 family protein 0.011 0.0185 0.0185
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0242 0.0432 0.043
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.5334 1 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0061 0.0092 0.0876
Loa Loa (eye worm) hypothetical protein 0.0473 0.0867 0.0867
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0049 0.0137
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0046 0.0133
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 0.0513 0.1488
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.0279 0.0279
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.1846 0.3446 1
Trypanosoma brucei protein tyrosine phosphatase 1 0.0231 0.0413 0.394
Echinococcus granulosus dual specificity protein kinase clk2 0.0061 0.0092 0.009
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0231 0.0413 0.0413
Onchocerca volvulus 0.0231 0.0413 0.1193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0145 0.0145
Schistosoma mansoni cpg binding protein 0.0028 0.0031 0.0031
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0069 0.0069
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0076 0.0076
Echinococcus granulosus transferase 0.0074 0.0118 0.0116
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0473 0.0867 0.0866
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0002 0.0001
Echinococcus granulosus neuropeptide receptor A26 0.0485 0.089 0.0888
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0049 0.0468
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0035 0.0044 0.0127
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0231 0.0413 0.0413
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0035 0.0044 0.0417
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0231 0.0413 0.0413
Leishmania major endonuclease G, putative 0.0284 0.0512 0.4893
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0242 0.0432 0.0432
Trypanosoma brucei endonuclease G, putative 0.0284 0.0512 0.4893
Echinococcus granulosus hypothetical protein 0.006 0.0091 0.0089
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0357 0.0648 0.0647
Toxoplasma gondii cytochrome p450 superfamily protein 0.0035 0.0044 0.0852
Echinococcus multilocularis lipoxygenase domain containing protein 0.006 0.009 0.0088
Schistosoma mansoni loxhd1 0.006 0.009 0.009
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.0239 0.0838
Onchocerca volvulus 0.0231 0.0413 0.1193
Loa Loa (eye worm) hypothetical protein 0.0027 0.0028 0.0028
Schistosoma mansoni cytochrome P450 0.0035 0.0044 0.0044
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0003 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0027 0.0257
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0029
Brugia malayi CXXC zinc finger family protein 0.0028 0.0031 0.0031
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0005 0.0005
Echinococcus granulosus cytochrome P450 2K1 0.0035 0.0044 0.0042
Loa Loa (eye worm) doublecortin family protein 0.006 0.009 0.009
Echinococcus multilocularis muscleblind protein 0.0145 0.025 0.0248
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.0279 0.0278
Echinococcus multilocularis dna polymerase eta 0.0063 0.0096 0.0094
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.006 0.009 0.009
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0003 0.0003
Echinococcus multilocularis 0.006 0.0091 0.0089
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0242 0.0432 0.0432
Echinococcus multilocularis muscleblind protein 1 0.0145 0.025 0.0248
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.1022 0.1898 0.1898
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0049 0.0468
Schistosoma mansoni hypothetical protein 0.0345 0.0626 0.0626
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0231 0.0413 0.0413
Trypanosoma cruzi hypothetical protein, conserved 0.0569 0.1047 1
Leishmania major protein kinase, putative 0.0013 0.0003 0.0025
Loa Loa (eye worm) hypothetical protein 0.0399 0.0727 0.0727
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0061 0.0092 0.0876
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0035 0.0044 0.0417
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.009 0.0262
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0145 0.0143
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0242 0.0432 0.043
Echinococcus multilocularis gpi ethanolamine phosphate transferase 3 0.0074 0.0118 0.0116
Schistosoma mansoni cpg binding protein 0.003 0.0034 0.0034
Leishmania major DNA polymerase kappa, putative 0.0038 0.0049 0.0468
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0003 0.0025
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0061 0.0092 0.0876
Schistosoma mansoni DNA polymerase eta 0.0063 0.0096 0.0096
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.1846 0.3446 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0003 0.0003
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0045 0.0125
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.5334 1 1
Onchocerca volvulus 0.0231 0.0413 0.1193
Giardia lamblia DINP protein human, muc B family 0.0038 0.0049 0.0142
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0231 0.0413 0.0413
Giardia lamblia Phosphatidylinositol-glycan biosynthesis, class O protein 0.0074 0.0118 0.0342
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Echinococcus multilocularis dual specificity protein kinase clk2 0.0061 0.0092 0.009
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0399 0.0727 0.0726
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0049 0.0468
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0035 0.0044 0.0127
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0473 0.0867 0.0866
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0049 0.0049
Brugia malayi PAS domain containing protein 0.0049 0.0069 0.0069
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0003 0.0003
Trypanosoma brucei unspecified product 0.0038 0.0049 0.0468
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0045 0.0429
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0002 0.0001
Echinococcus multilocularis neuropeptide receptor A26 0.0485 0.089 0.0888
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0231 0.0413 0.0411
Echinococcus multilocularis Polycystic kidney disease protein 0.006 0.009 0.0088
Loa Loa (eye worm) hypothetical protein 0.0473 0.0867 0.0867
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0284 0.0512 0.4893
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0045 0.0125
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0076 0.0076
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Echinococcus multilocularis lipoxygenase domain containing protein 0.006 0.009 0.0088
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0231 0.0413 0.0413
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0035 0.0044 0.0127
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0074 0.0118 0.0334
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0231 0.0413 0.119
Onchocerca volvulus 0.0231 0.0413 0.1193
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0029 0.0029
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0035 0.0044 0.0127
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0035 0.0044 0.0127
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1846 0.3446 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0035 0.0044 0.0127
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.009 0.02
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0231 0.0413 0.0413
Onchocerca volvulus 0.0028 0.0031 0.0084
Leishmania major hypothetical protein, conserved 0.0569 0.1047 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.0513 0.1481
Echinococcus granulosus muscleblind protein 0.0145 0.025 0.0248
Loa Loa (eye worm) hypothetical protein 0.0145 0.025 0.025
Onchocerca volvulus 0.0231 0.0413 0.1193
Onchocerca volvulus 0.0231 0.0413 0.1193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0145 0.0145
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0231 0.0413 0.0411
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0005 0.0005
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0231 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0003 0.0027
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0242 0.0432 0.043
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0231 0.0413 0.0411
Echinococcus multilocularis Endonuclease G 0.0284 0.0512 0.0511
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0231 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0074 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.0074 0.0118 0.0118
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0231 0.0413 0.0413
Echinococcus multilocularis lamin dm0 0.0027 0.0029 0.0027
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0284 0.0512 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0851 0.1577 0.1576
Trypanosoma brucei GPI ethanolamine phosphate transferase 3, putative 0.0074 0.0118 0.1125
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0513 0.1484
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0513 0.1484
Brugia malayi Protein kinase domain containing protein 0.0061 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0063 0.0096 0.0096
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1846 0.3446 1
Loa Loa (eye worm) hypothetical protein 0.016 0.0278 0.0278
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0049 0.0468
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0231 0.0413 0.0411
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Schistosoma mansoni endonuclease related 0.0284 0.0512 0.0512
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0145 0.0145
Schistosoma mansoni pcd6 interacting protein-related 0.0231 0.0413 0.0413
Brugia malayi Protein-tyrosine phosphatase 0.0231 0.0413 0.0413
Giardia lamblia Kinase, CMGC CLK 0.0061 0.0092 0.0266
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0231 0.0413 0.0413
Plasmodium falciparum GPI ethanolamine phosphate transferase 3, putative 0.0074 0.0118 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0231 0.0413 0.0411
Trypanosoma brucei endonuclease G, putative 0.0284 0.0512 0.4893
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0473 0.0867 0.0866
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0231 0.0413 0.0413
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0399 0.0727 0.0726
Schistosoma mansoni lipoxygenase 0.0357 0.0648 0.0648
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0003 0.0003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0049 0.0468
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Onchocerca volvulus 0.0027 0.0029 0.0078
Schistosoma mansoni rab6-interacting 0.006 0.009 0.009
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0035 0.0044 0.0127
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0031 0.0031
Trypanosoma cruzi cytochrome P450, putative 0.0052 0.0076 0.0727
Leishmania major protein kinase, putative 0.0061 0.0092 0.0876
Leishmania major cytochrome p450-like protein 0.0035 0.0044 0.0417
Schistosoma mansoni hypothetical protein 0.0074 0.0118 0.0118
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0231 0.0413 0.0413
Onchocerca volvulus 0.0036 0.0046 0.0128
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0035 0.0044 0.0127
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0231 0.0413 0.0413
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0049 0.0468
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.0513 0.1484
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.1846 0.3446 0.3446
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0049 0.0468
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.009 0.0262
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Brugia malayi hypothetical protein 0.006 0.009 0.009
Onchocerca volvulus 0.0231 0.0413 0.1193
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.1846 0.3446 1
Loa Loa (eye worm) hypothetical protein 0.0231 0.0413 0.0413
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0035 0.0044 0.0417
Echinococcus multilocularis lamin 0.0027 0.0029 0.0027
Echinococcus multilocularis cpg binding protein 0.003 0.0034 0.0032

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.19 uM Antiproliferative activity against human MCF7 cells by MTT assay ChEMBL. 16499313

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 16499313

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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