Detailed information for compound 1006002

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 232.258 | Formula: C11H8N2O2S
  • H donors: 1 H acceptors: 2 LogP: 2.68 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNc1nc2c(s1)c1ccc(=O)oc1cc2
  • InChi: 1S/C11H8N2O2S/c1-12-11-13-7-3-4-8-6(10(7)16-11)2-5-9(14)15-8/h2-5H,1H3,(H,12,13)
  • InChiKey: NGXVYGOSTMJAQZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.007 0.0061
Plasmodium falciparum methionine--tRNA ligase, putative 0.0023 0.0062 0.0182
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.065 0.4633
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0158 0.1076
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0038 0.009
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0158 0.1076
Brugia malayi MBOAT family protein 0.0042 0.0169 0.0162
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0158 0.015
Loa Loa (eye worm) hypothetical protein 0.0042 0.0169 0.0161
Brugia malayi Wnt-2 protein precursor 0.0014 0.001 0.0004
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0158 0.0148
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0038 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0216 0.1169 0.8817
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0685 0.5125
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0038 0.009
Onchocerca volvulus 0.0042 0.0169 0.0537
Loa Loa (eye worm) hypothetical protein 0.0023 0.0062 0.0055
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0087 0.0431 0.1894
Trichomonas vaginalis conserved hypothetical protein 0.0216 0.1169 0.8817
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.1666 0.7559
Echinococcus granulosus chromobox protein 1 0.0072 0.0341 0.0331
Entamoeba histolytica hypothetical protein 0.0112 0.0571 1
Schistosoma mansoni wnt related 0.0014 0.001 0.000000000017228
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0255 0.1393 1
Leishmania major hypothetical protein, unknown function,protein, unknown function 0.0087 0.0431 0.1894
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0042 0.0169 0.0159
Loa Loa (eye worm) hypothetical protein 0.0042 0.0169 0.0161
Plasmodium vivax methionine--tRNA ligase, putative 0.0023 0.0062 0.0182
Onchocerca volvulus Fatty acid synthase homolog 0.0044 0.0183 0.0588
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0158 0.1076
Brugia malayi Thioredoxin reductase 0.0055 0.0245 0.0239
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0041 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0169 0.1186
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0038 0.009
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0202 0.0196
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0041 0.0235
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0041 0.0104
Brugia malayi Glycosylation related protein 12, isoform 0.0036 0.0134 0.0128
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0042 0.0169 0.0161
Echinococcus multilocularis leucyl tRNA synthetase 0.0023 0.0062 0.0052
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0038 0.009
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0015 0.0013 0.0005
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0079 0.0798
Brugia malayi wnt family protein 0.0014 0.001 0.0004
Loa Loa (eye worm) hypothetical protein 0.004 0.016 0.0152
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.016 0.0507
Toxoplasma gondii tRNA ligases class I (M) protein 0.0023 0.0062 0.0283
Leishmania major glycerol uptake protein, putative 0.0042 0.0169 0.0688
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0173 0.0708
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0158 0.0148
Echinococcus granulosus zinc finger protein 0.0022 0.0053 0.0043
Echinococcus multilocularis zinc finger transcription factor gli2 0.0322 0.178 0.1772
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0038 0.0212
Plasmodium falciparum glutathione reductase 0.0055 0.0245 0.1569
Toxoplasma gondii thioredoxin reductase 0.0055 0.0245 0.1115
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0202 0.0192
Onchocerca volvulus 0.0038 0.0145 0.0456
Toxoplasma gondii hypothetical protein 0.0049 0.0209 0.095
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.014 0.013
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0002
Mycobacterium ulcerans hypothetical protein 0.0087 0.0431 0.4982
Brugia malayi MBOAT family protein 0.0042 0.0169 0.0162
Loa Loa (eye worm) hypothetical protein 0.0023 0.0062 0.0055
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0047 0.0196 0.019
Entamoeba histolytica hypothetical protein 0.0112 0.0571 1
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0023 0.0062 0.0052
Brugia malayi Bromodomain containing protein 0.0078 0.0379 0.0373
Schistosoma mansoni hypothetical protein 0.0021 0.005 0.004
Loa Loa (eye worm) hypothetical protein 0.0039 0.0154 0.0147
Trypanosoma brucei trypanothione reductase 0.0055 0.0245 0.1039
Mycobacterium tuberculosis Conserved protein 0.004 0.0158 0.1076
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0015 0.0013 0.0005
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0061 0.0279 0.1949
Schistosoma mansoni ap endonuclease 0.002 0.0041 0.0031
Brugia malayi Zinc finger, C2H2 type family protein 0.0322 0.178 0.1775
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0065 0.0409
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0065 0.0409
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.007 0.044
Loa Loa (eye worm) hypothetical protein 0.004 0.0158 0.015
Brugia malayi Pre-SET motif family protein 0.0031 0.0108 0.0102
Schistosoma mansoni zinc finger protein 0.0022 0.0053 0.0043
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.0571 0.0562
Brugia malayi wnt family protein 0.0014 0.001 0.0004
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0041 0.0104
Plasmodium falciparum methionine--tRNA ligase 0.0061 0.0279 0.1825
Schistosoma mansoni zinc finger protein 0.0042 0.0169 0.0159
Giardia lamblia Leucyl-tRNA synthetase 0.0023 0.0062 0.0998
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0015 0.0013 0.0007
Schistosoma mansoni ap endonuclease 0.002 0.0041 0.0031
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0038 0.0145 0.0137
Echinococcus granulosus cpg binding protein 0.0032 0.0113 0.0103
Brugia malayi Heterochromatin protein 1 0.0072 0.0341 0.0335
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.2255 0.2247
Trichomonas vaginalis conserved hypothetical protein 0.004 0.016 0.1119
Schistosoma mansoni cpg binding protein 0.0032 0.0113 0.0103
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0042 0.0169 0.0159
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0079 0.0503
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0041 0.0023
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0015 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0049 0.0208 0.02
Brugia malayi methionyl-tRNA synthetase 0.0061 0.0279 0.0273
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.014 0.0944
Loa Loa (eye worm) hypothetical protein 0.0042 0.0169 0.0161
Mycobacterium tuberculosis Conserved protein 0.004 0.0158 0.1076
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.007 0.0582
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0248 0.1356 1
Toxoplasma gondii Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 0.0036 0.0134 0.0612
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0015 0.0013 0.0003
Mycobacterium leprae Probable lipase LipE 0.004 0.0158 0.1917
Trypanosoma cruzi glycerol uptake protein, putative 0.0042 0.0169 0.0688
Brugia malayi diacylglycerol acyltransferase family protein 0.0395 0.2198 0.2194
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0002
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0015 0.0013 0.0003
Echinococcus multilocularis sterol O acyltransferase 1 0.0042 0.0169 0.0159
Loa Loa (eye worm) hypothetical protein 0.0103 0.052 0.0512
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0042 0.0169 0.0159
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0038 0.0032
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0289 0.0279
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0173 0.0708
Loa Loa (eye worm) hypothetical protein 0.0042 0.0168 0.016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0342 0.1894 0.1886
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.0793 0.0787
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0041 0.0124
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0289 0.0279
Loa Loa (eye worm) CWN-2 protein 0.0014 0.001 0.0002
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.002 0.0046 0.0342
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.065 0.4633
Loa Loa (eye worm) hhat protein 0.0042 0.0169 0.0161
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0029 0.0019
Schistosoma mansoni methionine-tRNA synthetase 0.0061 0.0279 0.0269
Loa Loa (eye worm) hypothetical protein 0.015 0.0793 0.0786
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0092 0.0604
Treponema pallidum alginate O-acetylation protein (algI) 0.0042 0.0169 1
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0042 0.0169 0.0159
Trichomonas vaginalis transmembrane protein nessy, putative 0.0042 0.0169 0.1186
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0061 0.0279 0.2026
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0041 0.0031
Mycobacterium leprae conserved hypothetical protein 0.004 0.0158 0.1917
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0041 0.0215
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0248 0.1356 0.1347
Toxoplasma gondii methionyl-tRNA synthetase 0.0061 0.0279 0.1268
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0015 0.0013 0.0007
Loa Loa (eye worm) MBOAT family protein 0.0042 0.0169 0.0161
Echinococcus multilocularis methionine tRNA synthetase 0.0061 0.0279 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.0216 0.1169 0.8817
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0038 0.009
Leishmania major leucyl-tRNA synthetase, putative 0.0023 0.0062 0.0201
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0015 0.0013 0.0003
Brugia malayi MH2 domain containing protein 0.0118 0.0605 0.06
Brugia malayi MBOAT family protein 0.0042 0.0169 0.0162
Brugia malayi G-protein alpha subunit 0.0015 0.0013 0.0007
Treponema pallidum leucyl-tRNA synthetase 0.0023 0.0062 0.1842
Brugia malayi Pax transcription factor protein 2 0.0518 0.2906 0.2902
Schistosoma mansoni cpg binding protein 0.0032 0.0113 0.0103
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0015 0.0013 0.0003
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0158 0.1076
Onchocerca volvulus 0.004 0.0158 0.0501
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0245 0.0235
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0005
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0751 0.336
Schistosoma mansoni zinc finger protein 0.0016 0.0019 0.0009
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0158 0.1076
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0202 0.0196
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0177 0.1253
Toxoplasma gondii exonuclease III APE 0.002 0.0041 0.0188
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0015 0.0013 0.0003
Schistosoma mansoni chromobox protein 0.0072 0.0341 0.0331
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0009 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0153
Plasmodium vivax glutathione reductase, putative 0.0055 0.0245 0.1569
Schistosoma mansoni hypothetical protein 0.0173 0.0925 0.0916
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0079 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0216 0.1169 0.8817
Brugia malayi Pre-SET motif family protein 0.0213 0.1155 0.115
Schistosoma mansoni hypothetical protein 0.0048 0.0202 0.0192
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0087 0.0431 0.1894
Echinococcus granulosus alpha 13 mannosyl glycoprotein 0.0105 0.0535 0.0526
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0158 0.0639
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0033 0.0025
Schistosoma mansoni bromodomain containing protein 0.0066 0.031 0.03
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0042 0.0169 0.0159
Leishmania major hypothetical protein, conserved 0.004 0.0158 0.0639
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0042 0.0169 0.0159
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.1666 0.7559
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0158 0.1654
Trichomonas vaginalis conserved hypothetical protein 0.0216 0.1169 0.8817
Echinococcus multilocularis geminin 0.0173 0.0925 0.0916
Schistosoma mansoni sterol O-acyltransferase 1 0.0042 0.0169 0.0159
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.1751 1 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0177 0.0568
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.1666 0.7559
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0038 0.009
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0038 0.009
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.002 0.0092
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0015 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0002
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0041 0.0505
Entamoeba histolytica hypothetical protein 0.0112 0.0571 1
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0015 0.0013 0.0005
Chlamydia trachomatis leucine--tRNA ligase 0.0023 0.0062 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0605 0.0598
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0042 0.0169 0.0159
Echinococcus multilocularis cpg binding protein 0.0032 0.0113 0.0103
Loa Loa (eye worm) beta-lactamase 0.004 0.0158 0.015
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.0571 0.0562
Onchocerca volvulus 0.0043 0.0174 0.0557
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0038 0.0174
Mycobacterium ulcerans polyketide synthase 0.0025 0.007 0.0582
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0038 0.009
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0038 0.0028
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0038 0.0198
Chlamydia trachomatis methionine--tRNA ligase 0.0023 0.0062 1
Onchocerca volvulus 0.004 0.0158 0.0501
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0017 0.0009
Giardia lamblia Methionyl-tRNA synthetase 0.0061 0.0279 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0153
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0395 0.2198 0.2192
Trichomonas vaginalis esterase, putative 0.004 0.0158 0.1104
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.005 0.0042
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.0844 0.6032
Loa Loa (eye worm) hypothetical protein 0.0105 0.0535 0.0528
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0169 0.1186
Loa Loa (eye worm) hypothetical protein 0.0072 0.0344 0.0337
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0015 0.0013 0.0003
Trypanosoma cruzi GUP1, putative 0.0042 0.0169 0.0688
Trypanosoma cruzi GUP1, putative 0.0042 0.0169 0.0688
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0341 0.2501
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0033 0.0153
Onchocerca volvulus 0.0043 0.0175 0.056
Onchocerca volvulus 0.0243 0.1324 0.4532
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0258 0.1176
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0042 0.0169 0.2787
Loa Loa (eye worm) G protein alpha subunit 3 0.0015 0.0013 0.0005
Echinococcus multilocularis chromobox protein 1 0.0072 0.0341 0.0331
Schistosoma mansoni hypothetical protein 0.0048 0.0202 0.0192
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0023 0.0062 0.049
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0087 0.0431 0.0422
Onchocerca volvulus 0.0023 0.0061 0.0164
Echinococcus granulosus o acyltransferase membrane bound domain 0.0042 0.0169 0.0159
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0015 0.0013 0.0007
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0248 0.1356 0.6168
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0015 0.0013 0.0003
Onchocerca volvulus Huntingtin homolog 0.0121 0.0625 0.2117
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.014 0.0944
Mycobacterium tuberculosis Probable thioesterase TesA 0.002 0.0046 0.027
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0173 0.0708
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0341 0.0334
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0158 0.0148
Schistosoma mansoni hypothetical protein 0.0016 0.0019 0.0009
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0015 0.0013 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0038 0.009
Loa Loa (eye worm) hypothetical protein 0.0032 0.011 0.0102
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0158 0.0152
Echinococcus multilocularis GPCR, family 2 0.0048 0.0202 0.0192
Echinococcus multilocularis alpha 1,3 mannosyl glycoprotein 0.0105 0.0535 0.0526
Mycobacterium ulcerans hypothetical protein 0.004 0.0158 0.1654
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0038 0.009
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.0793 0.0787
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0061 0.0279 0.1193
Loa Loa (eye worm) hypothetical protein 0.0042 0.0169 0.0161
Brugia malayi Bromodomain containing protein 0.0039 0.0154 0.0148
Entamoeba histolytica hypothetical protein 0.0042 0.0169 0.2787
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0042 0.0169 0.0159
Trypanosoma cruzi glycerol uptake protein, putative 0.0042 0.0169 0.0688
Schistosoma mansoni hypothetical protein 0.0112 0.0571 0.0562
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0342 0.1894 0.1886
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0092 0.0084
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0038 0.009
Brugia malayi glutathione reductase 0.0055 0.0245 0.0239
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0202 0.0192
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0041 0.0229
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0015 0.0013 0.0003
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0015 0.0013 0.0003
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0226 0.0954
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0062 0.0182
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0038 0.0174
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0042 0.0169 0.0159
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0038 0.0198
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0033 0.0153
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0208 0.0198
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0202 0.0192
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0158 0.0639
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0038 0.009
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0015 0.0013 0.0003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0342 0.1894 0.1888
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0079 0.0798
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0079 0.0503
Treponema pallidum methionyl-tRNA synthetase 0.0023 0.0062 0.1842
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0208 0.0198
Brugia malayi hypothetical protein 0.0112 0.0571 0.0565
Toxoplasma gondii type I fatty acid synthase, putative 0.0017 0.0029 0.0133
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0041 0.0124
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0175 0.0165
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0015 0.0013 0.0007
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.007 0.0582
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0023 0.0062 0.0052
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0087 0.0431 0.1894
Plasmodium vivax hypothetical protein, conserved 0.004 0.0158 0.0908
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0202 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0092 0.0604
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.065 0.4633
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0248 0.1356 0.1349
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0061 0.0279 0.1193
Brugia malayi hypothetical protein 0.0121 0.0625 0.062
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0041 0.0215
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0245 0.0235
Trichomonas vaginalis porcupine, putative 0.0042 0.0169 0.1186
Toxoplasma gondii diacylglycerol acyltransferase 0.0087 0.0431 0.1963
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0158 0.1104
Onchocerca volvulus 0.0032 0.011 0.0335
Mycobacterium tuberculosis Probable oxidoreductase 0.0139 0.0731 0.5215
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0042 0.0169 0.0159
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0395 0.2198 1
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.014 0.1659
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0342 0.1894 0.1886
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0125 0.065 0.8864
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0139 0.0731 0.5215
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0158 0.1654
Mycobacterium tuberculosis Conserved protein 0.004 0.0158 0.1076
Leishmania major diacylglycerol acyltransferase, putative 0.0087 0.0431 0.1894
Loa Loa (eye worm) hypothetical protein 0.004 0.0158 0.015
Echinococcus multilocularis chromobox protein 1 0.0072 0.0341 0.0331
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0015 0.0013 0.0003
Leishmania major glycerol uptake protein, putative 0.0042 0.0169 0.0688
Brugia malayi GNT-I family protein 0.0105 0.0535 0.053
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0245 0.1039
Mycobacterium tuberculosis Probable reductase 0.0125 0.065 0.4633
Echinococcus granulosus methionine tRNA synthetase 0.0061 0.0279 0.0269
Schistosoma mansoni hypothetical protein 0.0048 0.0202 0.0192
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0015 0.0013 0.0003
Loa Loa (eye worm) hypothetical protein 0.0048 0.0202 0.0195
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0158 0.1104
Brugia malayi Hhat protein 0.0042 0.0169 0.0162
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0042 0.0169 0.0159
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0005
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0061 0.0279 1
Toxoplasma gondii dgat2l1-prov protein 0.0395 0.2198 1
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0015 0.0013 0.0003
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0079 0.0503
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0044 0.0254
Trypanosoma brucei glycerol uptake protein, putative 0.0042 0.0169 0.0688
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0061 0.0373
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0015 0.0013 0.0003
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0038 0.009
Loa Loa (eye worm) pax transcription factor protein 2 0.0518 0.2906 0.2901
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0041 0.0104
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.065 0.4633
Trypanosoma brucei glycerol uptake protein, putative 0.0042 0.0169 0.0688
Brugia malayi beta-lactamase family protein 0.004 0.0158 0.0152
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0015 0.0013 0.0003
Leishmania major methionyl-tRNA synthetase, putative 0.0061 0.0279 0.1193
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0016 0.0022
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0245 0.0237
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0005
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.007 0.044
Schistosoma mansoni cpg binding protein 0.0028 0.0092 0.0082
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0061 0.0054
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0245 0.1706
Brugia malayi CHD4 protein 0.0015 0.0017 0.0011
Mycobacterium ulcerans thioesterase TesA 0.002 0.0046 0.0295
Brugia malayi wnt family protein 0.0014 0.001 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0216 0.1169 0.8817
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0061 0.0279 0.3622
Schistosoma mansoni hypothetical protein 0.0173 0.0925 0.0916
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.1666 0.7559
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0041 0.0035
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0029 0.0019
Schistosoma mansoni methionine-tRNA synthetase 0.0023 0.0062 0.0052
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.1155 0.1149
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0098 0.0088
Leishmania major diacylglycerol acyltransferase, putative 0.0087 0.0431 0.1894
Onchocerca volvulus 0.004 0.0158 0.0501
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0041 0.0234
Echinococcus granulosus chromobox protein 1 0.0072 0.0341 0.0331
Onchocerca volvulus 0.0518 0.2906 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0002
Mycobacterium ulcerans thioesterase 0.002 0.0046 0.0295
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0042 0.0169 0.0159
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.1751 1 1
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0038 0.0192
Plasmodium vivax SET domain protein, putative 0.0031 0.0108 0.0527
Loa Loa (eye worm) hypothetical protein 0.0036 0.0134 0.0127
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0042 0.0285
Schistosoma mansoni GTP-binding protein alpha subunit 0.0015 0.0013 0.0003
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0158 0.0148
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.007 0.0582
Loa Loa (eye worm) hypothetical protein 0.0206 0.1116 0.1109
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0029 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0108 0.0098
Entamoeba histolytica hypothetical protein 0.0112 0.0571 1
Mycobacterium ulcerans lipase LipD 0.004 0.0158 0.1654
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.0793 0.0786
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0042 0.0246
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0342 0.1894 0.1889
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.052 0.0514
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0158 0.1104
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0342 0.1894 0.1886
Loa Loa (eye worm) glutathione reductase 0.0055 0.0245 0.0237
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0751 0.336
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0342 0.1894 0.1886
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0158 0.1104
Brugia malayi beta-lactamase family protein 0.004 0.0158 0.0152
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0017 0.0007
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0282 0.0272
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0061 0.0053
Schistosoma mansoni GTP-binding protein alpha subunit 0.0015 0.0013 0.0003
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0015 0.0013 0.0007
Echinococcus granulosus o acyltransferase membrane bound domain 0.0042 0.0169 0.0159
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0029 0.0019
Echinococcus granulosus expressed protein 0.0015 0.0013 0.0003
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0395 0.2198 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0158 0.015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0153
Loa Loa (eye worm) hypothetical protein 0.0045 0.0189 0.0181
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0061 0.0279 0.0271
Schistosoma mansoni hypothetical protein 0.0042 0.0169 0.0159
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0038 0.0198
Brugia malayi methionyl-tRNA synthetase 0.0023 0.0062 0.0056
Loa Loa (eye worm) hypothetical protein 0.0121 0.0625 0.0618
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0079 0.0688
Plasmodium falciparum thioredoxin reductase 0.0055 0.0245 0.1569
Brugia malayi MBOAT family protein 0.0042 0.0169 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0169 0.1186
Brugia malayi wnt family protein 0.0014 0.001 0.0004
Echinococcus granulosus zinc finger transcription factor gli2 0.0322 0.178 0.1772
Trichomonas vaginalis conserved hypothetical protein 0.0216 0.1169 0.8817
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0079 0.0688
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0038 0.0028
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0041 0.0023
Loa Loa (eye worm) wnt-4 protein 0.0014 0.001 0.0002
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0023 0.0062 0.0998
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0208 0.0198
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0173 0.0708
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0108 0.0098
Echinococcus granulosus o acyltransferase membrane bound domain 0.0042 0.0169 0.0159
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0395 0.2198 0.2191
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0023 0.0062 0.0882
Brugia malayi beta-lactamase 0.004 0.0158 0.0152
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0015 0.0013 0.0003
Toxoplasma gondii hypothetical protein 0.0042 0.0169 0.0767
Entamoeba histolytica hypothetical protein, conserved 0.0042 0.0169 0.2787
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0079 0.0798
Trichomonas vaginalis conserved hypothetical protein 0.0216 0.1169 0.8817
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.1751 1 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0139 0.0731 1
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0038 0.0192
Echinococcus multilocularis zinc finger protein 0.0022 0.0053 0.0043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0013 0.0002
Schistosoma mansoni alpha-13-mannosyl-glycoprotein beta-1 2-n-acetylglucosaminyltransferase 0.0105 0.0535 0.0526
Schistosoma mansoni hypothetical protein 0.0087 0.0431 0.0422
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.014 0.1431
Brugia malayi PHD-finger family protein 0.0027 0.0084 0.0078
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0158 0.1076
Loa Loa (eye worm) hypothetical protein 0.004 0.0158 0.015
Leishmania major hypothetical protein, conserved 0.0042 0.0169 0.0688
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0038 0.009
Onchocerca volvulus 0.0395 0.2198 0.7554
Schistosoma mansoni hypothetical protein 0.0103 0.052 0.051
Brugia malayi MBOAT family protein 0.0042 0.0169 0.0162
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0248 0.1356 0.1347
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0395 0.2198 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0042 0.0246
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0017 0.0007
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.007 0.044
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.007 0.0064
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0158 0.1104
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0042 0.0169 0.0159
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.007 0.0061
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0108 0.049
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.014 0.013
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0005
Brugia malayi hypothetical protein 0.0015 0.0013 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0016 0.0022
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0015 0.0013 0.0003
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0015 0.0013 0.0007
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0015 0.0013 0.0003
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0042 0.0169 0.0159
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0015 0.0013 0.0003
Brugia malayi chromobox protein homolog 3 0.004 0.016 0.0154
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0177 0.1253
Mycobacterium ulcerans polyketide synthase 0.0026 0.0079 0.0688
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.007 0.0674
Mycobacterium ulcerans hypothetical protein 0.0159 0.0844 1
Loa Loa (eye worm) fatty acid synthase 0.0024 0.0068 0.006
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0015 0.0013 0.0003
Toxoplasma gondii hypothetical protein 0.0084 0.0413 0.1878
Onchocerca volvulus Huntingtin homolog 0.0121 0.0625 0.2117
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0605 0.0598
Toxoplasma gondii mono- or diacylglycerol acyltransferase 0.0087 0.0431 0.1963
Schistosoma mansoni leucyl-tRNA synthetase 0.0023 0.0062 0.0052
Loa Loa (eye worm) zinc finger protein 0.0322 0.178 0.1774
Brugia malayi diacylglycerol acyltransferase 0.0248 0.1356 0.1351
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0002
Toxoplasma gondii ABC1 family protein 0.004 0.0158 0.0718
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0153
Entamoeba histolytica vacuolar protein sorting 26 0.0042 0.0169 0.2787
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0153
Loa Loa (eye worm) MBOAT family protein 0.0042 0.0169 0.0161
Loa Loa (eye worm) hypothetical protein 0.0041 0.0166 0.0158
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0087 0.0431 0.1894
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0342 0.1894 0.1886
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0038 0.009
Plasmodium vivax methionine--tRNA ligase, putative 0.0061 0.0279 0.1825
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.007 0.0582
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0042 0.0169 0.0159
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.007 0.0674
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0158 0.1076
Loa Loa (eye worm) hypothetical protein 0.0023 0.0062 0.0055
Loa Loa (eye worm) hypothetical protein 0.1751 1 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0009 0.0003
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0139 0.0731 0.5215
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0038 0.009
Brugia malayi protein ZK524.3 0.0023 0.0062 0.0056
Schistosoma mansoni hypothetical protein 0.0048 0.0202 0.0192
Brugia malayi CXXC zinc finger family protein 0.0028 0.0092 0.0086
Trichomonas vaginalis set domain proteins, putative 0.0243 0.1324 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0017 0.0007
Schistosoma mansoni hypothetical protein 0.0404 0.2255 0.2247
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0042 0.0169 0.2787
Leishmania major glycerol uptake protein, putative 0.0042 0.0169 0.0688
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0015 0.0013 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0342 0.1894 0.1886
Loa Loa (eye worm) hypothetical protein 0.004 0.0158 0.015
Echinococcus multilocularis expressed protein 0.0015 0.0013 0.0003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0041 0.0104
Schistosoma mansoni chromobox protein 0.0072 0.0341 0.0331
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0042 0.0169 0.2787
Loa Loa (eye worm) Wnt2 protein 0.0014 0.001 0.0002
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0042 0.0169 0.0159
Loa Loa (eye worm) MBOAT family protein 0.0042 0.0169 0.0161
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0153
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0202 0.0195
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0248 0.1356 0.6168
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0751 0.336
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0061 0.0279 0.3123
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0158 0.0639
Echinococcus granulosus geminin 0.0173 0.0925 0.0916
Echinococcus granulosus sterol O acyltransferase 1 0.0042 0.0169 0.0159
Loa Loa (eye worm) hhat protein 0.0042 0.0169 0.0161
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0245 0.1569
Trypanosoma cruzi glycerol uptake protein, putative 0.0042 0.0169 0.0688
Onchocerca volvulus 0.0028 0.0092 0.0273
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0038 0.0028
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0087 0.0431 0.1894
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0015 0.0013 0.0003
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0208 0.0198
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0087 0.0431 0.0422
Brugia malayi Wnt-4 protein precursor 0.0014 0.001 0.0004
Leishmania major glycerol uptake protein, putative 0.0042 0.0169 0.0688
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0248 0.1356 1
Leishmania major glycerol uptake protein, putative 0.0042 0.0169 0.0688
Mycobacterium ulcerans beta-lactamase 0.004 0.0158 0.1654
Echinococcus granulosus GPCR family 2 0.0048 0.0202 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.004 0.016 0.1119
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.003 0.0153
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0248 0.1356 0.1347
Loa Loa (eye worm) hypothetical protein 0.0105 0.0535 0.0528
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.007 0.0061
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0341 0.2501
Loa Loa (eye worm) hypothetical protein 0.004 0.0158 0.015
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0041 0.0034
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.0571 0.0562
Loa Loa (eye worm) hypothetical protein 0.0121 0.0625 0.0618
Echinococcus granulosus dnaJ subfamily B 0.0404 0.2255 0.2247
Leishmania major diacylglycerol acyltransferase, putative 0.0395 0.2198 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.065 0.4633
Leishmania major trypanothione reductase 0.0055 0.0245 0.1039

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0 % Anticonvulsant activity in Albino mouse assessed as protection against pentylenetetrazole-induced seizures at 100 mg/kg, ip administered 1 hr before pentylenetetrazole challenge ChEMBL. 18467106

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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