Detailed information for compound 1018246

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 302.325 | Formula: C16H18N2O4
  • H donors: 1 H acceptors: 4 LogP: -0.07 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCCO[C@H]1CCC[C@H]2C1=C(C(=O)O)N1[C@H]2/C(=C\C)/C1=O
  • InChi: 1S/C16H18N2O4/c1-2-9-13-10-5-3-6-11(22-8-4-7-17)12(10)14(16(20)21)18(13)15(9)19/h2,10-11,13H,3-6,8H2,1H3,(H,20,21)/b9-2+/t10-,11-,13-/m0/s1
  • InChiKey: FUPMZGCETKRXTR-FFKCEWRFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major acetyl-CoA synthetase, putative 0.007 0.0089 0.005
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0048 0.0396
Mycobacterium ulcerans acyl-CoA synthetase 0.0237 0.0385 0.6822
Echinococcus multilocularis sterol regulatory element binding protein 0.0296 0.0488 0.0483
Brugia malayi STAT protein, DNA binding domain containing protein 0.0129 0.0193 0.1628
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0078 0.0103 0.0415
Chlamydia trachomatis pyruvate kinase 0.0134 0.0201 0.6299
Leishmania major phosphoglycerate kinase C, glycosomal 0.0169 0.0265 0.0716
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0019 0.0073
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0405 0.0681 0.2291
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Brugia malayi hypothetical protein 0.0444 0.075 0.6339
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.007 0.0089 0.1988
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0405 0.0681 0.2434
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0169 0.0265 0.2558
Loa Loa (eye worm) pyruvate kinase 0.0028 0.0015 0.0119
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0318 0.0526 0.2137
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0321 0.0532 0.5893
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0228 0.0369 0.1192
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0019 0.0014
Loa Loa (eye worm) phosphatidylinositol 3 0.0078 0.0103 0.0862
Brugia malayi Patched family protein 0.0042 0.0039 0.0332
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0106 0.0134
Echinococcus multilocularis GPCR, family 2 0.0047 0.0049 0.0044
Schistosoma mansoni patched 1 0.0296 0.0488 0.1982
Brugia malayi Patched family protein 0.0042 0.0039 0.0332
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0063 0.0077 0.2357
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0078 0.0103 0.03
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.0163 0.2224
Schistosoma mansoni DNA ligase IV 0.0059 0.007 0.0279
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.0038 0.0865
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0041 0.0038 0.0343
Onchocerca volvulus Protein patched homolog 0.0042 0.0039 0.0277
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0405 0.0681 0.2434
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0063 0.0077 0.0072
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Echinococcus granulosus pyruvate kinase 0.0134 0.0201 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.007 0.0089 0.0409
Trypanosoma cruzi pyruvate kinase 2, putative 0.0134 0.0201 0.0525
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0048 0.0051 0.0536
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.004 0.0037 0.0312
Brugia malayi acetyl-Coenzyme A synthetase 2 0.007 0.0089 0.0749
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0177 0.0279 0.4527
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0049 0.0059
Mycobacterium ulcerans hypothetical protein 0.0079 0.0106 0.0776
Brugia malayi Patched family protein 0.0042 0.0039 0.0332
Brugia malayi Phosphoglycerate kinase 0.0062 0.0075 0.0636
Echinococcus granulosus pyruvate kinase 0.0069 0.0087 0.0109
Brugia malayi mbt repeat family protein 0.0047 0.0048 0.0406
Brugia malayi PHD-finger family protein 0.0028 0.0014 0.0122
Schistosoma mansoni lozenge 0.0056 0.0064 0.0255
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0318 0.0526 0.1819
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0019 0.0019
Leishmania major hypothetical protein, unknown function 0.0078 0.0103 0.0105
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0059 0.0237
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0078 0.0103 0.03
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.011 0.3579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Giardia lamblia Pyruvate kinase 0.0069 0.0087 0.0276
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0405 0.0681 0.2291
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0063 0.0077 0.0309
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0078 0.0103 0.0871
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0049 0.0407
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0019 0.0161
Onchocerca volvulus 0.0079 0.0106 0.1183
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0019 0.0073
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0019 0.0014
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0059 0.007 0.0000056284
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0318 0.0526 0.4447
Echinococcus multilocularis phosphoglycerate kinase 1 0.0169 0.0265 0.026
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.011 0.0104
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0048 0.0051 0.1353
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0078 0.0103 0.3337
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0078 0.0103 0.0546
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0019 0.0151
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0089 0.0359
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0019 0.0073
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0078 0.0103 0.0546
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0078 0.0103 0.0415
Loa Loa (eye worm) hypothetical protein 0.0237 0.0385 0.3245
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0059 0.007 0.0821
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0019 0.0151
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0078 0.0103 0.1322
Echinococcus multilocularis microtubule associated protein 2 0.1412 0.2459 0.2455
Onchocerca volvulus 0.0047 0.0048 0.0396
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0405 0.0681 0.0904
Leishmania major 4-coumarate:coa ligase-like protein 0.0237 0.0385 0.1171
Mycobacterium leprae conserved hypothetical protein 0.0078 0.0103 0.238
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.006 0.1211
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.006 0.0055
Loa Loa (eye worm) hypothetical protein 0.0177 0.0279 0.2348
Toxoplasma gondii patched family protein 0.0042 0.0039 0.0364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0228 0.0369 0.4896
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0078 0.0103 0.0098
Toxoplasma gondii patched family protein 0.0042 0.0039 0.0364
Brugia malayi Patched family protein 0.0042 0.0039 0.0332
Brugia malayi Immunoglobulin I-set domain containing protein 0.0064 0.0078 0.0659
Brugia malayi nuclear receptor NHR-88 0.003 0.0019 0.0161
Toxoplasma gondii patched family protein 0.0042 0.0039 0.0364
Treponema pallidum DNA ligase (lig) 0.0059 0.007 0.2189
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0078 0.0103 0.0133
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0106 0.0587
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0019 0.0161
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0078 0.0103 0.0546
Brugia malayi hypothetical protein 0.0059 0.007 0.0589
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0048 0.0043
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0048 0.0051 0.042
Echinococcus multilocularis pyruvate kinase 0.0069 0.0087 0.0081
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Mycobacterium ulcerans lipase LipD 0.0079 0.0106 0.0776
Entamoeba histolytica hypothetical protein 0.0078 0.0103 0.03
Loa Loa (eye worm) hypothetical protein 0.0363 0.0606 0.5114
Brugia malayi hypothetical protein 0.0042 0.0039 0.0332
Schistosoma mansoni coup transcription factor 0.003 0.0019 0.0073
Leishmania major phosphatidylinositol 3-kinase, putative 0.0078 0.0103 0.0105
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0019 0.0073
Onchocerca volvulus 0.0042 0.0039 0.0277
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0078 0.0103 0.0546
Brugia malayi pyruvate kinase, muscle isozyme 0.0028 0.0015 0.0128
Brugia malayi CHE-14 protein 0.0296 0.0488 0.4125
Trichomonas vaginalis antibiotic synthetase, putative 0.007 0.0089 0.0309
Entamoeba histolytica phosphoglycerate kinase, putative 0.0169 0.0265 0.175
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.011 0.1902
Toxoplasma gondii TIM10 family protein, putative 0.0048 0.0051 0.0536
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0228 0.0369 0.2686
Loa Loa (eye worm) hypothetical protein 0.003 0.0019 0.0151
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.007 0.0089 0.0409
Brugia malayi beta-lactamase 0.0079 0.0106 0.0892
Echinococcus granulosus replication factor c subunit 1 0.0059 0.007 0.0086
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0019 0.0014
Echinococcus granulosus death domain containing protein 0.0064 0.0078 0.0097
Loa Loa (eye worm) hypothetical protein 0.0177 0.0279 0.2348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0078 0.0103 0.0098
Brugia malayi hypothetical protein 0.0042 0.0039 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Schistosoma mansoni phosphoglycerate kinase 0.0169 0.0265 0.1072
Treponema pallidum phosphoglycerate kinase 0.0169 0.0265 1
Trypanosoma brucei phosphoglycerate kinase 0.0062 0.0075 0.0091
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.001 0.0037
Toxoplasma gondii isocitrate dehydrogenase 0.0063 0.0077 0.0934
Entamoeba histolytica hypothetical protein 0.0318 0.0526 0.41
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.011 0.0861
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Echinococcus multilocularis replication factor c subunit 1 0.0059 0.007 0.0065
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0216 0.0346 0.0457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Toxoplasma gondii propionate-CoA ligase 0.007 0.0089 0.1104
Echinococcus granulosus FTZ F1 alpha 0.003 0.0019 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0237 0.0385 0.3252
Schistosoma mansoni cpg binding protein 0.0063 0.0077 0.0308
Loa Loa (eye worm) phosphatidylinositol 3 0.0078 0.0103 0.0862
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.4253 0.748 0.7479
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.011 0.1902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0228 0.0369 0.4896
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0059 0.007 0.0589
Schistosoma mansoni hypothetical protein 0.0103 0.0147 0.0592
Brugia malayi Patched protein homolog 1 0.0042 0.0039 0.0332
Loa Loa (eye worm) hypothetical protein 0.0079 0.0106 0.0883
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0078 0.0103 0.0871
Echinococcus multilocularis pyruvate kinase 0.0134 0.0201 0.0196
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.011 0.3579
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0106 0.0571
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0019 0.0073
Mycobacterium tuberculosis Conserved protein 0.0079 0.0106 0.0571
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.007 0.0089 0.0409
Onchocerca volvulus Pyruvate kinase homolog 0.0134 0.0201 0.2494
Entamoeba histolytica hypothetical protein 0.0216 0.0346 0.2484
Loa Loa (eye worm) beta-lactamase 0.0079 0.0106 0.0883
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0078 0.0103 0.0546
Plasmodium vivax acetyl-CoA synthetase, putative 0.007 0.0089 0.2788
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Schistosoma mansoni fkbp-rapamycin associated protein 0.0228 0.0369 0.1496
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0078 0.0103 0.03
Onchocerca volvulus 0.0042 0.0039 0.0277
Brugia malayi beta-lactamase family protein 0.0079 0.0106 0.0892
Loa Loa (eye worm) hypothetical protein 0.0237 0.0385 0.3245
Brugia malayi AMP-binding enzyme family protein 0.007 0.0089 0.0749
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0216 0.0346 0.0341
Echinococcus granulosus Niemann Pick C1 protein 0.069 0.1184 0.1577
Mycobacterium leprae Probable lipase LipE 0.0079 0.0106 0.2447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0063 0.0077 0.0072
Loa Loa (eye worm) oxidoreductase 0.007 0.0089 0.0739
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0177 0.0279 1
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0078 0.0103 0.3337
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0078 0.0103 0.0546
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0049 0.0417
Loa Loa (eye worm) isocitrate dehydrogenase 0.0063 0.0077 0.0643
Brugia malayi DKFZp564C0469 protein 0.0059 0.007 0.0589
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0019 0.0161
Trypanosoma brucei beta lactamase 0.0154 0.0237 0.2741
Echinococcus multilocularis expressed conserved protein 0.0648 0.111 0.1105
Schistosoma mansoni topbp1 0.0059 0.007 0.0279
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0019 0.0161
Echinococcus granulosus Niemann Pick C1 protein 0.0986 0.1707 0.2276
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0106 0.0776
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0063 0.0077 0.2357
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.007 0.0089 0.0075
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0028 0.0022
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Schistosoma mansoni zinc finger protein 0.0022 0.0005 0.0016
Loa Loa (eye worm) hypothetical protein 0.0177 0.0279 0.2348
Entamoeba histolytica acyl-coA synthetase, putative 0.0237 0.0385 0.2829
Onchocerca volvulus Protein patched homolog 0.0042 0.0039 0.0277
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0228 0.0369 0.0364
Giardia lamblia Hypothetical protein 0.0078 0.0103 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0254 0.0415 0.565
Brugia malayi Probable ClpP-like protease 0.0082 0.011 0.0925
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0078 0.0103 0.1322
Mycobacterium ulcerans phosphoglycerate kinase 0.0169 0.0265 0.422
Giardia lamblia Phosphatidylinositol 4-kinase 0.0078 0.0103 0.0546
Brugia malayi Patched family protein 0.0042 0.0039 0.0332
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0154 0.0237 0.6008
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.069 0.1184 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0059 0.0502
Echinococcus granulosus cpg binding protein 0.0063 0.0077 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0019 0.0161
Toxoplasma gondii ABC1 family protein 0.0079 0.0106 0.1359
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0078 0.0103 0.3337
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0078 0.0103 0.0546
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0405 0.0681 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0405 0.0681 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.0182 0.0737
Loa Loa (eye worm) hypothetical protein 0.0064 0.0078 0.0654
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0169 0.0265 0.3748
Loa Loa (eye worm) hypothetical protein 0.0045 0.0045 0.0371
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0019 0.0161
Leishmania major 4-coumarate:coa ligase-like protein 0.0237 0.0385 0.1171
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0154 0.0237 0.2215
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0045 0.0053
Loa Loa (eye worm) pyruvate kinase-PB 0.0093 0.013 0.109
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0063 0.0077 0.0072
Plasmodium falciparum phosphoglycerate kinase 0.0169 0.0265 0.9462
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0237 0.0385 0.4059
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0019 0.0161
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0078 0.0103 0.0546
Echinococcus multilocularis expressed protein 0.0048 0.0051 0.0046
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0089 0.1988
Echinococcus granulosus expressed conserved protein 0.0648 0.111 0.1478
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Brugia malayi Patched related family protein 4 0.0042 0.0039 0.0332
Echinococcus multilocularis pyruvate kinase 0.0105 0.0152 0.0147
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0078 0.0103 0.0098
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0169 0.0265 0.0776
Echinococcus multilocularis pyruvate kinase 0.0069 0.0087 0.0081
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0075 0.0022
Entamoeba histolytica hypothetical protein 0.0078 0.0103 0.03
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Brugia malayi AMP-binding enzyme family protein 0.0237 0.0385 0.3252
Loa Loa (eye worm) hypothetical protein 0.003 0.0019 0.0151
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0078 0.0103 0.1322
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0045 0.0177
Toxoplasma gondii ATPase, AAA family protein 0.0059 0.007 0.0821
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0078 0.0103 0.0131
Mycobacterium ulcerans acyl-CoA synthetase 0.0237 0.0385 0.6822
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0089 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0063 0.0077 0.0123
Leishmania major acetyl-CoA synthetase, putative 0.007 0.0089 0.005
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0063 0.0077 0.003
Loa Loa (eye worm) MBCTL1 0.0053 0.0059 0.0493
Loa Loa (eye worm) hypothetical protein 0.0472 0.08 0.6757
Toxoplasma gondii pyruvate kinase PyKII 0.0069 0.0087 0.1074
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0237 0.0385 0.6822
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0254 0.0415 0.6007
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0059 0.007 0.1477
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0405 0.0681 0.2434
Brugia malayi Patched family protein 0.0042 0.0039 0.0332
Schistosoma mansoni thyroid hormone receptor 0.003 0.0019 0.0073
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.007 0.0089 0.0359
Brugia malayi AMP-binding enzyme family protein 0.007 0.0089 0.0749
Entamoeba histolytica hypothetical protein 0.0216 0.0346 0.2484
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0019 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.007 0.0089 0.005
Schistosoma mansoni hypothetical protein 0.0096 0.0136 0.0547
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.007 0.0089 0.0739
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0048 0.0057
Leishmania major pyruvate kinase 0.0134 0.0201 0.0477
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0136 0.1147
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0075 0.0069
Loa Loa (eye worm) hypothetical protein 0.003 0.0019 0.0151
Leishmania major hypothetical protein, conserved 0.1558 0.2718 1
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0019 0.0014
Brugia malayi hypothetical protein 0.0042 0.0039 0.0332
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0078 0.0103 0.0546
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Schistosoma mansoni chromosome transmission fidelity factor 0.0059 0.007 0.0279
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0078 0.0103 0.0133
Loa Loa (eye worm) hypothetical protein 0.003 0.0019 0.0151
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0078 0.0103 0.03
Onchocerca volvulus 0.0096 0.0136 0.1595
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0078 0.0103 0.0546
Trichomonas vaginalis replication factor C large subunit, putative 0.0059 0.007 0.0000056284
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0019 0.0019
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0405 0.0681 0.2291
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0048 0.0191
Giardia lamblia Pyruvate kinase 0.0134 0.0201 0.2155
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Schistosoma mansoni ankyrin 23/unc44 0.0064 0.0078 0.0313
Loa Loa (eye worm) hypothetical protein 0.0228 0.0369 0.311
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0405 0.0681 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0078 0.0103 0.0131
Mycobacterium ulcerans hypothetical protein 0.0237 0.0385 0.6822
Entamoeba histolytica hypothetical protein 0.0216 0.0346 0.2484
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0237 0.0385 0.6822
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.0147 0.1239
Brugia malayi hypothetical protein 0.0042 0.0039 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.0265 0.2228
Trypanosoma cruzi target of rapamycin kinase 3 0.0405 0.0681 0.2434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0254 0.0415 0.565
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0168 0.0262 0.2521
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.024 0.0389 0.1271
Schistosoma mansoni pyruvate kinase 0.0134 0.0201 0.0815
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0075 0.0093
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0405 0.0681 1
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.006 0.0073
Brugia malayi beta-lactamase family protein 0.0079 0.0106 0.0892
Loa Loa (eye worm) hypothetical protein 0.0079 0.0106 0.0883
Loa Loa (eye worm) hypothetical protein 0.0237 0.0385 0.3245
Brugia malayi Patched family protein 0.0042 0.0039 0.0332
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.0038 0.032
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0106 0.2447
Plasmodium vivax acyl-CoA synthetase, putative 0.0177 0.0279 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0106 0.0425
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0078 0.0103 0.0415
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0089 0.0409
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0075 0.0022
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0049 0.0059
Brugia malayi FAT domain containing protein 0.0177 0.0277 0.2344
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0019 0.0019
Brugia malayi hypothetical protein 0.0472 0.08 0.676
Loa Loa (eye worm) phosphatidylinositol 3 0.0078 0.0103 0.0862
Schistosoma mansoni hypothetical protein 0.0284 0.0467 0.1896
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0078 0.0103 0.0415
Onchocerca volvulus 0.0042 0.0039 0.0277
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0078 0.0103 0.0105
Brugia malayi steroid hormone receptor 0.003 0.0019 0.0161
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.001 0.0005
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0078 0.0103 0.0131
Echinococcus multilocularis serine protein kinase ATM 0.0318 0.0526 0.0522
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0106 0.0571
Loa Loa (eye worm) hypothetical protein 0.0059 0.007 0.058
Trypanosoma brucei phosphoglycerate kinase, putative 0.0062 0.0075 0.0091
Schistosoma mansoni cpg binding protein 0.0063 0.0077 0.0308
Schistosoma mansoni cpg binding protein 0.0058 0.0068 0.0271
Schistosoma mansoni hypothetical protein 0.0064 0.0078 0.0313
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0106 0.0587
Loa Loa (eye worm) pyruvate kinase 0.0134 0.0201 0.1694
Echinococcus multilocularis Protein lozenge 0.0056 0.0064 0.0059
Brugia malayi Protein kinase domain containing protein 0.0064 0.0078 0.0659
Toxoplasma gondii patched family protein 0.0042 0.0039 0.0364
Onchocerca volvulus 0.0042 0.0039 0.0277
Entamoeba histolytica hypothetical protein 0.0216 0.0346 0.2484
Schistosoma mansoni hypothetical protein 0.0047 0.0049 0.0196
Echinococcus multilocularis Ankyrin 0.0064 0.0078 0.0073
Brugia malayi Isocitrate dehydrogenase 0.0063 0.0077 0.0653
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0078 0.0103 0.0862
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.007 0.0089 0.0409
Loa Loa (eye worm) patched family protein 0.0042 0.0039 0.0323
Toxoplasma gondii target of rapamycin (TOR), putative 0.0405 0.0681 1
Leishmania major phosphoglycerate kinase B, cytosolic 0.0169 0.0265 0.0716
Loa Loa (eye worm) STAT protein 0.0129 0.0193 0.162
Brugia malayi Patched family protein 0.0042 0.0039 0.0332
Loa Loa (eye worm) hypothetical protein 0.0177 0.0279 0.2348
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0064 0.0078 0.0314
Entamoeba histolytica protein kinase rad3, putative 0.0228 0.0369 0.2686
Mycobacterium ulcerans acyl-CoA synthetase 0.0237 0.0385 0.6822
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.007 0.0089 0.0112
Onchocerca volvulus 0.007 0.0089 0.0951
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0078 0.0103 0.0131
Loa Loa (eye worm) hypothetical protein 0.0059 0.007 0.058
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.007 0.0089 0.0409
Trichomonas vaginalis PIKK family atypical protein kinase 0.0228 0.0369 0.4896
Echinococcus granulosus survival motor neuron protein 1 0.0472 0.08 0.1064
Loa Loa (eye worm) hypothetical protein 0.0079 0.0106 0.0883
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0019 0.0161
Schistosoma mansoni phosphoglycerate kinase 0.0169 0.0265 0.1072
Onchocerca volvulus Pyruvate kinase homolog 0.0134 0.0201 0.2494
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.007 0.0089 0.0359
Brugia malayi Pyruvate kinase, muscle isozyme 0.0134 0.0201 0.1702
Trypanosoma brucei phosphoglycerate kinase 0.0169 0.0265 0.3189
Brugia malayi Patched family protein 0.0042 0.0039 0.0332
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0045 0.0039
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0078 0.0103 0.1322
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0019 0.0019
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0078 0.0103 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.015 0.0231 0.2644
Plasmodium falciparum lipid/sterol:H+ symporter 0.0042 0.0039 0.092
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0075 0.0022
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.007 0.0089 0.0359
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.0038 0.032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0082 0.011 0.204
Mycobacterium tuberculosis Conserved protein 0.0079 0.0106 0.0571
Giardia lamblia GTOR 0.0405 0.0681 1
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0019 0.0073
Schistosoma mansoni netrin receptor unc5 0.0064 0.0078 0.0313
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.0038 0.032
Echinococcus granulosus pyruvate kinase 0.0069 0.0087 0.0109
Echinococcus multilocularis protein dispatched 1 0.0338 0.0562 0.0557
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.007 0.0089 0.1104
Echinococcus granulosus Protein patched homolog 1 0.0296 0.0488 0.0646
Brugia malayi Patched family protein 0.0042 0.0039 0.0332
Loa Loa (eye worm) hypothetical protein 0.0177 0.0279 0.2348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Schistosoma mansoni hypothetical protein 0.0078 0.0103 0.0415
Echinococcus multilocularis cpg binding protein 0.0063 0.0077 0.0072
Loa Loa (eye worm) hypothetical protein 0.0053 0.0059 0.0493
Echinococcus multilocularis dnaJ subfamily B 0.0824 0.1421 0.1417
Loa Loa (eye worm) patched family protein 0.0042 0.0039 0.0323
Loa Loa (eye worm) hypothetical protein 0.0078 0.0103 0.0862
Loa Loa (eye worm) hypothetical protein 0.003 0.0019 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0019 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Trypanosoma brucei phosphoglycerate kinase 0.0169 0.0265 0.3189
Leishmania major phosphatidylinositol 3-kinase, putative 0.0405 0.0681 0.2291
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0169 0.0265 0.0776
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0177 0.0277 0.0364
Onchocerca volvulus 0.007 0.0089 0.0951
Leishmania major phosphatidylinositol kinase, putative 0.0078 0.0103 0.0105
Brugia malayi protein C24B5.3 0.0042 0.0039 0.0332
Toxoplasma gondii pyruvate kinase PyK1 0.0134 0.0201 0.2799
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0405 0.0681 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0045 0.0053
Echinococcus granulosus sterol regulatory element binding protein 0.0296 0.0488 0.0646
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0106 0.0587
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0019 0.0019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0106 0.0425
Brugia malayi Phosphoglycerate kinase 0.0169 0.0265 0.2236
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0134 0.0201 0.1768
Echinococcus multilocularis Niemann Pick C1 protein 0.069 0.1184 0.1179
Loa Loa (eye worm) patched family protein 0.0042 0.0039 0.0323
Leishmania major 4-coumarate:coa ligase-like protein 0.0237 0.0385 0.1171
Plasmodium falciparum acetyl-CoA synthetase, putative 0.007 0.0089 0.2788
Echinococcus granulosus netrin receptor unc 5 0.0064 0.0078 0.0097
Echinococcus multilocularis netrin receptor unc 5 0.0064 0.0078 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.015 0.0231 0.2644
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0184 0.0291 0.0286
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0405 0.0681 0.2765
Schistosoma mansoni hypothetical protein 0.0285 0.0469 0.1905
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.0231 0.1948
Loa Loa (eye worm) hypothetical protein 0.0041 0.0038 0.0311
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0405 0.0681 0.2291
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0019 0.0019
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0078 0.0103 0.03
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0318 0.0526 0.7473
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0106 0.0571
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0078 0.0103 0.0546
Onchocerca volvulus Pyruvate kinase homolog 0.0134 0.0201 0.2494
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0089 0.0409
Echinococcus multilocularis pyruvate kinase 0.0134 0.0201 0.0196
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0045 0.0177
Loa Loa (eye worm) hypothetical protein 0.0103 0.0147 0.123
Loa Loa (eye worm) hypothetical protein 0.024 0.0389 0.3278
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0169 0.0265 0.3189
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0228 0.0369 0.0487
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0045 0.0367
Loa Loa (eye worm) hypothetical protein 0.003 0.0019 0.0151
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.007 0.0089 0.1104
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0078 0.0103 0.0871
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0106 0.0883
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0405 0.0681 0.5486
Echinococcus granulosus expressed protein 0.0048 0.0051 0.0061
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.007 0.0089 0.0359
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0078 0.0103 0.0098
Loa Loa (eye worm) hypothetical protein 0.0134 0.0201 0.1694
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Brugia malayi Patched related family protein 10 0.0042 0.0039 0.0332
Brugia malayi Uncoordinated protein 44 0.0064 0.0078 0.0659
Trypanosoma cruzi hypothetical protein, conserved 0.148 0.2581 1
Entamoeba histolytica hypothetical protein 0.0078 0.0103 0.03
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0063 0.0077 0.003
Loa Loa (eye worm) hypothetical protein 0.003 0.0019 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0063 0.0077 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0019 0.0151
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0019 0.0161
Brugia malayi nuclear hormone receptor 0.003 0.0019 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Schistosoma mansoni nuclear hormone receptor 0.003 0.0019 0.0073
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.011 0.014
Schistosoma mansoni hypothetical protein 0.0177 0.0277 0.1124
Echinococcus multilocularis 0.0078 0.0103 0.0098
Loa Loa (eye worm) hypothetical protein 0.004 0.0036 0.0294
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0106 0.0571
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0028 0.003
Entamoeba histolytica pyruvate kinase, putative 0.0093 0.013 0.0542
Loa Loa (eye worm) hypothetical protein 0.007 0.0089 0.0739
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0167 0.0261 0.076
Trypanosoma brucei pyruvate kinase 1 0.0134 0.0201 0.2155
Brugia malayi AMP-binding enzyme family protein 0.007 0.0089 0.0749
Echinococcus multilocularis protein patched 0.0296 0.0488 0.0483
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.007 0.058
Schistosoma mansoni hypothetical protein 0.0285 0.0469 0.1905
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0106 0.0143
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0048 0.0057
Loa Loa (eye worm) hypothetical protein 0.0078 0.0103 0.0862
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.011 0.0441
Onchocerca volvulus 0.0042 0.0039 0.0277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.011 0.1418
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0078 0.0103 0.0546
Mycobacterium tuberculosis Conserved protein 0.0079 0.0106 0.0571
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0089 0.0409
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0237 0.0385 0.6822
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0078 0.0103 0.0098
Echinococcus granulosus pyruvate kinase 0.0069 0.0087 0.0109
Brugia malayi Niemann-Pick C1 protein precursor 0.069 0.1184 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.007 0.0089 0.0075
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0078 0.0103 0.0546
Loa Loa (eye worm) hypothetical protein 0.015 0.0231 0.1939
Onchocerca volvulus 0.0042 0.0039 0.0277
Loa Loa (eye worm) hypothetical protein 0.0059 0.007 0.058
Entamoeba histolytica acyl-CoA synthetase, putative 0.0237 0.0385 0.2829
Trypanosoma brucei acetyl-CoA synthetase, putative 0.007 0.0089 0.0309
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0019 0.0073
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0228 0.0369 0.3117
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Schistosoma mansoni hypothetical protein 0.0285 0.0469 0.1905
Schistosoma mansoni hypothetical protein 0.0047 0.0049 0.0196
Brugia malayi hypothetical protein 0.0216 0.0346 0.2927
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0106 0.0776
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0405 0.0681 0.0904
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0049 0.0044
Brugia malayi Myosin head containing protein 0.0042 0.0039 0.0332
Echinococcus granulosus serine protein kinase ATM 0.0318 0.0526 0.0697
Echinococcus multilocularis survival motor neuron protein 1 0.0472 0.08 0.0795
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Brugia malayi hypothetical protein 0.0037 0.0031 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0228 0.0369 0.4896
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0078 0.0103 0.03
Echinococcus granulosus nuclear factor of activated T cells 5 0.0623 0.1066 0.142
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0169 0.0265 0.6749
Loa Loa (eye worm) phosphatidylinositol 3 0.0078 0.0103 0.0862
Loa Loa (eye worm) hypothetical protein 0.0082 0.011 0.0916
Brugia malayi Patched family protein 0.0042 0.0039 0.0332
Leishmania major phosphatidylinositol kinase related protein, putative 0.0167 0.0261 0.0701
Onchocerca volvulus 0.0058 0.0068 0.0665
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0169 0.0265 0.3748
Onchocerca volvulus 0.0078 0.0103 0.1149
Brugia malayi CXXC zinc finger family protein 0.0058 0.0068 0.0572
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0168 0.0262 0.2521
Mycobacterium ulcerans beta-lactamase 0.0079 0.0106 0.0776
Brugia malayi AMP-binding enzyme family protein 0.007 0.0089 0.0749
Loa Loa (eye worm) hypothetical protein 0.0059 0.007 0.058
Brugia malayi Patched related family protein 12 0.0042 0.0039 0.0332
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0078 0.0103 0.1322
Toxoplasma gondii isocitrate dehydrogenase 0.0063 0.0077 0.0934
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0106 0.0587
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Schistosoma mansoni hypothetical protein 0.0047 0.0049 0.0196
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.0089 0.0749
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0078 0.0103 0.0871
Echinococcus multilocularis Niemann Pick C1 protein 0.0986 0.1707 0.1702
Trichomonas vaginalis antibiotic synthetase, putative 0.007 0.0089 0.0309
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0019 0.0161
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.011 0.2553
Schistosoma mansoni hypothetical protein 0.0216 0.0346 0.1405
Brugia malayi Death domain containing protein 0.0064 0.0078 0.0659
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0078 0.0103 0.0133
Loa Loa (eye worm) hypothetical protein 0.0079 0.0106 0.0883
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0078 0.0103 0.0546
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0405 0.0681 0.5752
Brugia malayi hypothetical protein 0.0037 0.0031 0.0261
Leishmania major pyruvate kinase 0.0134 0.0201 0.0477
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0237 0.0385 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.0103 0.0546
Brugia malayi protein C24B5.3 0.0042 0.0039 0.0332
Loa Loa (eye worm) AMP-binding enzyme family protein 0.007 0.0089 0.0739
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0049 0.0417
Trichomonas vaginalis PIKK family atypical protein kinase 0.0318 0.0526 0.7473
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.006 0.0072 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Schistosoma mansoni hypothetical protein 0.0824 0.1421 0.5776
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0237 0.0385 0.4059
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0106 0.343
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0078 0.0103 0.3337
Brugia malayi Pax transcription activation domain interacting protein 0.0059 0.007 0.0589
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0089 0.0409
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0078 0.0103 0.0133
Echinococcus granulosus GPCR family 2 0.0047 0.0049 0.0059
Loa Loa (eye worm) phosphatidylinositol 3 0.0405 0.0681 0.5748
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0064 0.0078 0.065
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0405 0.0681 0.2434
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0019 0.0151
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0106 0.01
Echinococcus multilocularis isocitrate dehydrogenase 0.0063 0.0077 0.0072
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0019 0.0161
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.0038 0.0865
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0089 0.0409
Onchocerca volvulus 0.0237 0.0385 0.5002
Loa Loa (eye worm) phosphatidylinositol 3 0.0405 0.0681 0.5748
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0045 0.0377
Entamoeba histolytica hypothetical protein 0.0078 0.0103 0.03
Toxoplasma gondii FATC domain-containing protein 0.0318 0.0526 0.768
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.007 0.0089 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0068 0.0562
Loa Loa (eye worm) hypothetical protein 0.007 0.0089 0.0739
Loa Loa (eye worm) hypothetical protein 0.0038 0.0032 0.026
Plasmodium vivax patched family protein, putative 0.0042 0.0039 0.092
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0106 0.0892
Loa Loa (eye worm) pyruvate kinase 0.0134 0.0201 0.1694
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0078 0.0103 0.0133
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.007 0.0089 0.0359
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0078 0.0103 0.0546
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0168 0.0262 0.2521
Onchocerca volvulus 0.0078 0.0103 0.1149
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Brugia malayi Patched family protein 0.0042 0.0039 0.0332
Onchocerca volvulus 0.0079 0.0106 0.1183
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0078 0.0103 0.3337
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.007 0.0089 0.0359
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0078 0.0103 0.0871
Trichomonas vaginalis pyruvate kinase, putative 0.0134 0.0201 0.2155
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0078 0.0103 0.0415
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.007 0.0089 0.0409
Onchocerca volvulus 0.007 0.0089 0.0951
Brugia malayi Bromodomain containing protein 0.0038 0.0032 0.0268
Brugia malayi ecdysteroid receptor 0.003 0.0019 0.0161
Schistosoma mansoni niemann-pick C1 (NPC1) 0.07 0.1203 0.4888
Schistosoma mansoni acetyl-CoA synthetase 0.007 0.0089 0.0356
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.007 0.0089 0.0075
Loa Loa (eye worm) hypothetical protein 0.0047 0.0048 0.0396
Loa Loa (eye worm) hypothetical protein 0.0444 0.075 0.6336
Plasmodium vivax hypothetical protein, conserved 0.0078 0.0103 0.3337
Loa Loa (eye worm) runx1 0.0056 0.0064 0.0531
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0045 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.0277 0.3398
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0063 0.0077 0.0072
Trichomonas vaginalis pyruvate kinase, putative 0.0134 0.0201 0.2155
Plasmodium falciparum pyruvate kinase 0.0134 0.0201 0.7066
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0019 0.0161
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0177 0.0279 0.2735
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0623 0.1066 0.1062
Loa Loa (eye worm) hypothetical protein 0.0177 0.0277 0.2336
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0062 0.0075 0.0022
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0063 0.0077 0.0096
Schistosoma mansoni hypothetical protein 0.0285 0.0469 0.1905
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0064 0.0078 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0019 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0019 0.0161
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0169 0.0265 0.3189
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0019 0.0151
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0078 0.0103 0.0415
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.007 0.0089 0.017
Loa Loa (eye worm) hypothetical protein 0.0079 0.0106 0.0883
Brugia malayi Pyruvate kinase, M2 isozyme 0.0134 0.0201 0.1702
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0106 0.0587
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0059 0.0054
Loa Loa (eye worm) hypothetical protein 0.0254 0.0415 0.35
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0048 0.0191
Trichomonas vaginalis esterase, putative 0.0079 0.0106 0.0587
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0078 0.0103 0.03
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.0103 0.0546
Schistosoma mansoni hypothetical protein 0.0047 0.0049 0.0196
Echinococcus multilocularis pyruvate kinase 0.0069 0.0087 0.0081
Plasmodium vivax pyruvate kinase, putative 0.0134 0.0201 0.7066
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.4253 0.748 1
Giardia lamblia Phosphoglycerate kinase 0.0169 0.0265 0.3189
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0106 0.0571
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0048 0.0191
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0405 0.0681 0.5752
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0048 0.0396
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0019 0.0151
Loa Loa (eye worm) hypothetical protein 0.0059 0.007 0.058
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.007 0.0089 0.0075
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0078 0.0103 0.3337
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0078 0.0103 0.0546
Loa Loa (eye worm) hypothetical protein 0.069 0.1184 1
Schistosoma mansoni bromodomain containing protein 0.0065 0.0081 0.0324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0228 0.0369 0.4896
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0048 0.0043
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Echinococcus granulosus nibrin 0.0059 0.007 0.0086
Loa Loa (eye worm) pyruvate kinase 0.0134 0.0201 0.1694
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0019 0.0014
Schistosoma mansoni pyruvate kinase 0.0134 0.0201 0.0815
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0078 0.0103 0.0871
Schistosoma mansoni survival motor neuron protein 0.0096 0.0136 0.0547
Schistosoma mansoni pyruvate kinase 0.0069 0.0087 0.0348
Loa Loa (eye worm) phosphatidylinositol 3 0.0078 0.0103 0.0862
Brugia malayi AMP-binding enzyme family protein 0.0237 0.0385 0.3252
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0059 0.0073
Plasmodium vivax phosphoglycerate kinase, putative 0.0169 0.0265 0.9462
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0169 0.0265 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0228 0.0369 0.4896
Trypanosoma cruzi pyruvate kinase 2, putative 0.0134 0.0201 0.0525
Loa Loa (eye worm) hypothetical protein 0.0064 0.0078 0.065
Plasmodium vivax replication factor C subunit 1, putative 0.0059 0.007 0.2071
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0106 0.0571
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0078 0.0103 0.0546
Brugia malayi topoisomerase 0.0059 0.007 0.0589
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0089 0.0409
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Loa Loa (eye worm) hypothetical protein 0.0079 0.0106 0.0883
Entamoeba histolytica acyl-CoA synthetase, putative 0.0237 0.0385 0.2829
Mycobacterium tuberculosis Conserved hypothetical protein 0.0078 0.0103 0.054
Schistosoma mansoni microtubule-associated protein tau 0.1412 0.2459 1
Onchocerca volvulus 0.0042 0.0039 0.0277
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0078 0.0103 0.0133
Schistosoma mansoni topbp1 0.0059 0.007 0.0279
Echinococcus granulosus pyruvate kinase 0.0134 0.0201 0.0263
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0078 0.0103 0.0133
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0089 0.0409
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.001 0.0007
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0048 0.0051 0.0429
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.007 0.0089 0.0409
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.007 0.0089 0.0083
Toxoplasma gondii hypothetical protein 0.0042 0.0039 0.0364
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0078 0.0103 0.0546
Brugia malayi hypothetical protein 0.0059 0.007 0.0589
Brugia malayi mbt repeat family protein 0.0047 0.0048 0.0406
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0019 0.0151
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0237 0.0385 0.6822
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0507 0.0861 1
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.007 0.0089 0.1988
Echinococcus multilocularis Zinc finger, PHD finger 0.0078 0.0103 0.0098
Mycobacterium ulcerans pyruvate kinase 0.0134 0.0201 0.2852
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0019 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0254 0.0415 0.565
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0064 0.0078 0.0073
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0184 0.0291 0.0382
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0078 0.0103 0.0415
Echinococcus granulosus microtubule associated protein 2 0.1412 0.2459 0.3283
Loa Loa (eye worm) hypothetical protein 0.0069 0.0088 0.0733
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.011 0.0861
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0019 0.0019
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0237 0.0385 1
Leishmania major phosphatidylinositol 4-kinase, putative 0.0078 0.0103 0.0105
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0019 0.0014
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0078 0.0103 0.0546
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0078 0.0103 0.0871
Loa Loa (eye worm) patched family protein 0.0042 0.0039 0.0323
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Loa Loa (eye worm) hypothetical protein 0.0444 0.075 0.6336
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0075 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0296 0.0488 0.6848
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0063 0.0077 0.0217
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0106 0.0143
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0405 0.0681 0.2765
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.0681 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0405 0.0681 0.0676
Schistosoma mansoni hypothetical protein 0.0041 0.0038 0.0149
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0168 0.0262 0.2521
Brugia malayi Patched family protein 0.0042 0.0039 0.0332
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0405 0.0681 0.0676
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0106 0.0571
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0177 0.0277 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.0103 0.0546
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0019 0.0014
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.0231 0.1939
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0019 0.0014
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0059 0.0054
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0019 0.0073
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0405 0.0681 0.5486
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0078 0.0103 0.0133
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0059 0.0073
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0228 0.0369 0.4896
Schistosoma mansoni thyroid hormone receptor 0.003 0.0019 0.0073
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0059 0.007 0.0000030879
Mycobacterium ulcerans acetyl-CoA synthetase 0.007 0.0089 0.0409
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.0038 0.0033
Brugia malayi isocitrate dehydrogenase 0.0063 0.0077 0.0653
Brugia malayi Patched family protein 0.0042 0.0039 0.0332
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0059 0.007 0.0000056284
Mycobacterium leprae Probable pyruvate kinase PykA 0.0134 0.0201 0.504
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.007 0.0089 0.0409
Loa Loa (eye worm) hypothetical protein 0.0093 0.013 0.109
Onchocerca volvulus 0.0059 0.007 0.0693
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.0231 0.1948
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.011 0.3783
Leishmania major hypothetical protein, conserved 0.0079 0.0106 0.0115
Brugia malayi pyruvate kinase 0.0028 0.0015 0.0128
Echinococcus multilocularis nibrin 0.0059 0.007 0.0065
Brugia malayi Bromodomain containing protein 0.0077 0.0101 0.0854
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0089 0.0359
Onchocerca volvulus 0.0444 0.075 1
Brugia malayi Patched family protein 0.0042 0.0039 0.0332
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0106 0.0587
Plasmodium falciparum acyl-CoA synthetase 0.0177 0.0279 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.011 0.1418
Plasmodium falciparum pyruvate kinase 2 0.0069 0.0087 0.2711
Onchocerca volvulus 0.007 0.0089 0.0951
Echinococcus granulosus Ankyrin 0.0064 0.0078 0.0098
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0296 0.0488 0.4119
Plasmodium vivax hypothetical protein 0.0078 0.0103 0.3337
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0048 0.0051 0.1353
Loa Loa (eye worm) hypothetical protein 0.0296 0.0488 0.4119
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0019 0.0073
Trypanosoma brucei pyruvate kinase 1, putative 0.0134 0.0201 0.2155
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0049 0.0044
Echinococcus granulosus dnaJ subfamily B 0.0824 0.1421 0.1894
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0078 0.0103 0.03
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0048 0.0051 0.0202
Echinococcus granulosus phosphoglycerate kinase 1 0.0169 0.0265 0.0347
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0089 0.0409
Schistosoma mansoni transcription factor LCR-F1 0.0216 0.0346 0.1405
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.0042 0.0039 0.0323
Plasmodium vivax pyruvate kinase 2, putative 0.0069 0.0087 0.2711
Onchocerca volvulus 0.0079 0.0106 0.1183
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0063 0.0077 0.0007
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0078 0.0103 0.0546
Loa Loa (eye worm) patched family protein 0.0042 0.0039 0.0323
Mycobacterium ulcerans lipoprotein LpqF 0.0154 0.0237 0.3627
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0078 0.0103 0.0131
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0078 0.0103 0.0131
Onchocerca volvulus Netrin receptor homolog 0.0064 0.0078 0.0806
Chlamydia trachomatis phosphoglycerate kinase 0.0169 0.0265 0.9321
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0019 0.0161
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0078 0.0103 0.3337
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.007 0.0089 0.0309
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0089 0.0359
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0321 0.0532 1
Plasmodium falciparum replication factor C subunit 1, putative 0.0059 0.007 0.2071
Loa Loa (eye worm) phosphatidylinositol kinase 0.0078 0.0103 0.0862
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0019 0.0151
Loa Loa (eye worm) hypothetical protein 0.0047 0.0049 0.0407
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0078 0.0103 0.0131
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0019 0.0014

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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