TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 352.899 | Formula: C19H29ClN2O2
H donors: 0 H acceptors: 1 LogP: 4.08 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N([C@@H]1CCCC[C@H]1N1CCCC1)C)COc1ccccc1.Cl
InChi: 1S/C19H28N2O2.ClH/c1-20(19(22)15-23-16-9-3-2-4-10-16)17-11-5-6-12-18(17)21-13-7-8-14-21;/h2-4,9-10,17-18H,5-8,11-15H2,1H3;1H/t17-,18-;/m1./s1
InChiKey: YSBFTVWCIQTGEP-JAXOOIEVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Cavia porcellus	Mu opioid receptor	Starlite/ChEMBL	References
Cavia porcellus	Kappa opioid receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	Mu opioid receptor	98 aa	97 aa	36.1 %
Onchocerca volvulus		Kappa opioid receptor	380 aa	310 aa	25.8 %
Onchocerca volvulus		Mu opioid receptor	98 aa	79 aa	27.8 %
Brugia malayi	G protein-coupled receptor	Mu opioid receptor	98 aa	90 aa	31.1 %
Onchocerca volvulus		Mu opioid receptor	98 aa	89 aa	31.5 %
Schistosoma mansoni	biogenic amine (dopamine) receptor	Mu opioid receptor	98 aa	88 aa	39.8 %
Onchocerca volvulus	Phosphoinositide 3-kinase adapter subunit homolog	Kappa opioid receptor	380 aa	323 aa	22.6 %
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	Mu opioid receptor	98 aa	100 aa	29.0 %
Schistosoma mansoni	biogenic amine receptor	Mu opioid receptor	98 aa	97 aa	38.1 %
Echinococcus granulosus	tachykinin peptides receptor 99D	Mu opioid receptor	98 aa	93 aa	25.8 %
Onchocerca volvulus		Mu opioid receptor	98 aa	79 aa	27.8 %
Schistosoma japonicum	ko:K04255 opsin 4 (melanopsin), putative	Kappa opioid receptor	380 aa	352 aa	20.2 %
Brugia malayi	larval opioid receptor	Mu opioid receptor	98 aa	100 aa	24.0 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Mu opioid receptor	98 aa	97 aa	36.1 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	98 aa	31.6 %
Echinococcus multilocularis	g protein coupled receptor	Mu opioid receptor	98 aa	92 aa	26.1 %
Schistosoma japonicum	Neuropeptide Y receptor, putative	Mu opioid receptor	98 aa	100 aa	29.0 %
Brugia malayi	Serotonin/octopamine receptor family protein 7	Mu opioid receptor	98 aa	85 aa	32.9 %
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	Mu opioid receptor	98 aa	80 aa	37.5 %
Schistosoma japonicum	Muscarinic acetylcholine receptor M1, putative	Mu opioid receptor	98 aa	95 aa	30.5 %
Echinococcus granulosus	biogenic amine 5HT receptor	Mu opioid receptor	98 aa	97 aa	35.1 %
Schistosoma japonicum	ko:K04165 Oamb gene product from transcript, putative	Mu opioid receptor	98 aa	79 aa	34.2 %
Schistosoma japonicum	Probable G-protein coupled receptor No9, putative	Mu opioid receptor	98 aa	95 aa	28.4 %
Onchocerca volvulus		Mu opioid receptor	98 aa	96 aa	28.1 %
Echinococcus multilocularis	g protein coupled receptor	Mu opioid receptor	98 aa	81 aa	24.7 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	96 aa	31.2 %
Onchocerca volvulus		Mu opioid receptor	98 aa	101 aa	20.8 %
Schistosoma mansoni	amine GPCR	Mu opioid receptor	98 aa	86 aa	32.6 %
Schistosoma japonicum	ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative	Mu opioid receptor	98 aa	97 aa	37.1 %
Onchocerca volvulus	Phospholipase d-related homolog	Kappa opioid receptor	380 aa	326 aa	20.9 %
Onchocerca volvulus		Kappa opioid receptor	380 aa	310 aa	24.2 %
Onchocerca volvulus	Mitogen-activated protein kinase kinase kinase 8 homolog	Kappa opioid receptor	380 aa	395 aa	20.3 %
Schistosoma mansoni	opsin-like receptor	Mu opioid receptor	98 aa	80 aa	25.0 %
Echinococcus multilocularis	biogenic amine (5HT) receptor	Mu opioid receptor	98 aa	96 aa	30.2 %
Schistosoma japonicum	Alpha-1A adrenergic receptor, putative	Mu opioid receptor	98 aa	98 aa	34.7 %
Schistosoma mansoni	adenoreceptor	Mu opioid receptor	98 aa	88 aa	38.6 %
Onchocerca volvulus		Mu opioid receptor	98 aa	100 aa	25.0 %
Onchocerca volvulus		Mu opioid receptor	98 aa	87 aa	32.2 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Kappa opioid receptor	380 aa	313 aa	26.2 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Kappa opioid receptor	380 aa	392 aa	25.8 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	79 aa	29.1 %
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Kappa opioid receptor	380 aa	389 aa	25.7 %
Onchocerca volvulus		Kappa opioid receptor	380 aa	374 aa	27.5 %
Schistosoma japonicum	Octopamine receptor, putative	Mu opioid receptor	98 aa	98 aa	37.8 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Kappa opioid receptor	380 aa	326 aa	25.2 %
Echinococcus multilocularis	allatostatin A receptor	Kappa opioid receptor	380 aa	313 aa	27.2 %
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	Mu opioid receptor	98 aa	96 aa	29.2 %
Schistosoma japonicum	ko:K04207 neuropeptide Y receptor Y5, putative	Mu opioid receptor	98 aa	80 aa	31.2 %
Onchocerca volvulus		Mu opioid receptor	98 aa	85 aa	24.7 %
Echinococcus granulosus	allatostatin A receptor	Kappa opioid receptor	380 aa	317 aa	28.4 %
Onchocerca volvulus	Glycoprotein hormone beta 5 homolog	Mu opioid receptor	98 aa	92 aa	32.6 %
Schistosoma mansoni	rhodopsin-like orphan GPCR	Mu opioid receptor	98 aa	85 aa	25.9 %
Onchocerca volvulus	Programmed cell death protein 5 homolog	Kappa opioid receptor	380 aa	316 aa	22.2 %
Schistosoma japonicum	5-hydroxytryptamine receptor 4, putative	Mu opioid receptor	98 aa	79 aa	36.7 %
Onchocerca volvulus		Mu opioid receptor	98 aa	81 aa	25.9 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Mu opioid receptor	98 aa	96 aa	36.5 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	85 aa	37.6 %
Echinococcus granulosus	alpha 1A adrenergic receptor	Mu opioid receptor	98 aa	92 aa	21.7 %
Schistosoma mansoni	neuropeptide receptor	Mu opioid receptor	98 aa	93 aa	24.7 %
Echinococcus multilocularis	tachykinin peptides receptor 99D	Mu opioid receptor	98 aa	93 aa	25.8 %
Schistosoma japonicum	ko:K04282 thyrotropin-releasing hormone receptor, putative	Mu opioid receptor	98 aa	100 aa	28.0 %
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	Mu opioid receptor	98 aa	96 aa	29.2 %
Schistosoma japonicum	Neuropeptide Y receptor type 2, putative	Mu opioid receptor	98 aa	79 aa	31.6 %
Echinococcus granulosus	biogenic amine 5HT receptor	Mu opioid receptor	98 aa	96 aa	30.2 %
Echinococcus multilocularis	neuropeptide receptor	Mu opioid receptor	98 aa	88 aa	22.7 %
Brugia malayi	Melatonin receptor type 1A	Mu opioid receptor	98 aa	80 aa	22.5 %
Echinococcus multilocularis	neuropeptide Y receptor	Mu opioid receptor	98 aa	95 aa	32.6 %
Echinococcus granulosus	neuropeptide FF receptor 2	Mu opioid receptor	98 aa	84 aa	31.0 %
Brugia malayi	hypothetical protein	Kappa opioid receptor	380 aa	319 aa	21.6 %
Brugia malayi	ORL1-like opioid receptor	Kappa opioid receptor	380 aa	312 aa	25.3 %
Echinococcus multilocularis	neuropeptide FF receptor 2	Mu opioid receptor	98 aa	84 aa	31.0 %
Schistosoma mansoni	neuropeptide receptor	Mu opioid receptor	98 aa	81 aa	34.6 %
Onchocerca volvulus	RB1-inducible coiled-coil protein 1 homolog	Mu opioid receptor	98 aa	96 aa	31.2 %
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	Mu opioid receptor	98 aa	99 aa	36.4 %
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	Mu opioid receptor	98 aa	93 aa	33.3 %
Schistosoma japonicum	Rhodopsin, putative	Kappa opioid receptor	380 aa	329 aa	23.1 %
Schistosoma japonicum	Neuropeptide Y receptor, putative	Mu opioid receptor	98 aa	88 aa	23.9 %
Echinococcus granulosus	neuropeptide receptor	Mu opioid receptor	98 aa	88 aa	22.7 %
Schistosoma japonicum	Octopamine receptor, putative	Mu opioid receptor	98 aa	88 aa	37.5 %
Echinococcus multilocularis	serotonin receptor	Mu opioid receptor	98 aa	97 aa	35.1 %
Schistosoma mansoni	neuropeptide F-like receptor	Mu opioid receptor	98 aa	85 aa	32.9 %
Schistosoma mansoni	growth hormone secretagogue receptor	Mu opioid receptor	98 aa	93 aa	24.7 %
Onchocerca volvulus		Mu opioid receptor	98 aa	93 aa	36.6 %
Schistosoma mansoni	thyrotropin-releasing hormone receptor	Mu opioid receptor	98 aa	100 aa	27.0 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Mu opioid receptor	98 aa	97 aa	34.0 %
Loa Loa (eye worm)	melatonin receptor type 1A	Mu opioid receptor	98 aa	80 aa	22.5 %
Onchocerca volvulus		Mu opioid receptor	98 aa	86 aa	33.7 %
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	Mu opioid receptor	98 aa	100 aa	29.0 %
Onchocerca volvulus		Kappa opioid receptor	380 aa	310 aa	27.4 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Mu opioid receptor	98 aa	89 aa	38.2 %
Schistosoma mansoni	rhodopsin-like orphan GPCR	Kappa opioid receptor	380 aa	379 aa	22.4 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Mu opioid receptor	98 aa	90 aa	28.9 %
Echinococcus granulosus	g protein coupled receptor	Mu opioid receptor	98 aa	81 aa	24.7 %
Onchocerca volvulus		Mu opioid receptor	98 aa	81 aa	33.3 %
Loa Loa (eye worm)	neuropeptide F receptor	Mu opioid receptor	98 aa	80 aa	33.8 %
Schistosoma mansoni	biogenic amine (dopamine) receptor	Mu opioid receptor	98 aa	97 aa	35.1 %
Onchocerca volvulus		Mu opioid receptor	98 aa	80 aa	22.5 %
Onchocerca volvulus		Mu opioid receptor	98 aa	80 aa	35.0 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	93 aa	30.1 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Kappa opioid receptor	380 aa	334 aa	25.4 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Mu opioid receptor	98 aa	89 aa	40.4 %
Schistosoma mansoni	neuropeptide receptor	Mu opioid receptor	98 aa	95 aa	32.6 %
Echinococcus granulosus	somatostatin receptor	Kappa opioid receptor	380 aa	342 aa	19.6 %
Onchocerca volvulus	26S proteasome non-ATPase regulatory subunit 1 homolog	Mu opioid receptor	98 aa	80 aa	28.8 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	81 aa	35.8 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	92 aa	31.5 %
Schistosoma japonicum	FMRFamide receptor, putative	Mu opioid receptor	98 aa	109 aa	28.4 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	92 aa	23.9 %
Schistosoma mansoni	hypothetical protein	Mu opioid receptor	98 aa	100 aa	23.0 %
Onchocerca volvulus		Mu opioid receptor	98 aa	79 aa	21.5 %
Echinococcus multilocularis	rhodopsin orphan GPCR	Mu opioid receptor	98 aa	80 aa	23.8 %
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	Kappa opioid receptor	380 aa	306 aa	21.2 %
Schistosoma mansoni	biogenic amine receptor	Mu opioid receptor	98 aa	98 aa	35.7 %
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	Mu opioid receptor	98 aa	96 aa	32.3 %
Brugia malayi	hypothetical protein	Kappa opioid receptor	380 aa	320 aa	20.6 %
Onchocerca volvulus		Mu opioid receptor	98 aa	79 aa	31.6 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Kappa opioid receptor	380 aa	403 aa	23.3 %
Echinococcus granulosus	g protein coupled receptor	Mu opioid receptor	98 aa	92 aa	26.1 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Mu opioid receptor	98 aa	93 aa	25.8 %
Loa Loa (eye worm)	TYRA-2 protein	Mu opioid receptor	98 aa	87 aa	31.0 %
Echinococcus granulosus	neuropeptide Y receptor	Mu opioid receptor	98 aa	95 aa	32.6 %
Schistosoma mansoni	biogenic amine receptor	Mu opioid receptor	98 aa	91 aa	38.5 %
Brugia malayi	GnHR receptor homolog	Kappa opioid receptor	380 aa	341 aa	20.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	acetylcholinesterase	0.0063	0.0897	0.0897
Onchocerca volvulus	Cathepsin L homolog	0.0105	0.1556	0.7359
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0143	0.2163	1
Toxoplasma gondii	cathepsin CPC2	0.0033	0.0409	0.078
Schistosoma mansoni	biogenic amine receptor	0.0009	0.0031	0.0031
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0051	0.0051
Echinococcus granulosus	dnaJ subfamily B	0.0396	0.6203	0.6203
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0105	0.1556	0.4854
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0051	0.0051
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0105	0.1556	0.3139
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.0041
Schistosoma mansoni	BC026374 protein (S09 family)	0.0063	0.0897	0.0897
Brugia malayi	cathepsin F-like cysteine proteinase	0.0033	0.0409	0.0449
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0196	0.3005	0.3269
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0105	0.1556	0.3139
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0143	0.2163	1
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0093	0.137	0.1542
Plasmodium vivax	unspecified product	0.0062	0.0874	0.501
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1556	0.3139
Plasmodium vivax	unspecified product	0.0033	0.0409	0.1608
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0051	0.0051
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0033	0.0409	0.1608
Echinococcus multilocularis	cathepsin b	0.0559	0.8803	0.8803
Echinococcus granulosus	cathepsin L cysteine protease	0.0062	0.0874	0.0874
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.4543	1
Brugia malayi	Cathepsin L-like precursor	0.0105	0.1556	0.1754
Brugia malayi	Carboxylesterase family protein	0.0063	0.0897	0.1003
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0009	0.0031	0.0031
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.1556	0.3139
Echinococcus multilocularis	cathepsin b	0.0559	0.8803	0.8803
Schistosoma mansoni	Smad4	0.0008	0.0015	0.0015
Giardia lamblia	Cathepsin B precursor	0.0196	0.3005	0.6467
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0051	0.0096
Brugia malayi	Cathepsin L-like precursor	0.0105	0.1556	0.1754
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Brugia malayi	RE15519p	0.0009	0.0031	0.0018
Echinococcus granulosus	biogenic amine 5HT receptor	0.0009	0.0031	0.0031
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0051	0.0041
Leishmania major	cysteine peptidase A (CPA)	0.0105	0.1556	0.4854
Trypanosoma cruzi	major cysteine proteinase, putative	0.0033	0.0409	0.0255
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0355	0.0387
Echinococcus granulosus	fmrfamide receptor	0.0009	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0898	0.0898
Loa Loa (eye worm)	melatonin receptor type 1A	0.0009	0.0031	0.0018
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0652	0.0652
Brugia malayi	hypothetical protein	0.0009	0.0031	0.0018
Plasmodium falciparum	serine repeat antigen 3	0.0033	0.0409	0.1608
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0898	0.0898
Toxoplasma gondii	cathepsin CPL	0.0105	0.1556	0.4854
Brugia malayi	neuropeptide F receptor	0.0009	0.0031	0.0018
Schistosoma mansoni	neuropeptide F-like receptor	0.0009	0.0031	0.0031
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0009	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0093	0.137	0.1542
Schistosoma mansoni	myosin xvIII	0.0009	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Echinococcus multilocularis	cathepsin L cysteine protease	0.0105	0.1556	0.1556
Echinococcus multilocularis	cysteine protease	0.0105	0.1556	0.1556
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0409	0.0505
Brugia malayi	cathepsin L-like precursor	0.0075	0.1091	0.1225
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0063	0.0897	0.0897
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0898	0.1006
Echinococcus granulosus	acetylcholinesterase	0.0374	0.5848	0.5848
Schistosoma mansoni	hypothetical protein	0.0009	0.0031	0.0031
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0457	0.031
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0009	0.0031	0.0018
Onchocerca volvulus		0.0105	0.1556	0.7359
Schistosoma mansoni	cpg binding protein	0.0029	0.0358	0.0358
Schistosoma mansoni	cathepsin s	0.0029	0.0355	0.0355
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.1556	0.3139
Schistosoma mansoni	ap endonuclease	0.0019	0.0189	0.0189
Giardia lamblia	Cathepsin B precursor	0.0196	0.3005	0.6467
Brugia malayi	hypothetical protein	0.0009	0.0031	0.0018
Plasmodium falciparum	serine repeat antigen 8	0.0033	0.0409	0.1608
Giardia lamblia	Cysteine protease	0.0033	0.0409	0.0505
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0105	0.1556	0.3139
Onchocerca volvulus		0.0063	0.0897	0.4177
Loa Loa (eye worm)	neuropeptide F receptor	0.0009	0.0031	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Echinococcus granulosus	neuropeptides capa receptor	0.0009	0.0031	0.0031
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0051	0.0096
Schistosoma mansoni	hypothetical protein	0.0009	0.0031	0.0031
Brugia malayi	G-protein coupled receptor	0.0009	0.0031	0.0018
Loa Loa (eye worm)	ShTK domain-containing protein	0.0093	0.137	0.1542
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0051	0.0041
Echinococcus multilocularis	dro:myosuppressin receptor	0.0009	0.0031	0.0031
Trypanosoma cruzi	cysteine peptidase, putative	0.0105	0.1556	0.1587
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Schistosoma mansoni	hypothetical protein	0.0156	0.2372	0.2372
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0051	0.0041
Loa Loa (eye worm)	carboxylesterase	0.0374	0.5848	0.6637
Brugia malayi	neuropeptide F receptor	0.0009	0.0031	0.0018
Entamoeba histolytica	cysteine proteinase 1, putative	0.0062	0.0874	0.1573
Loa Loa (eye worm)	neuropeptide F receptor	0.0009	0.0031	0.0018
Brugia malayi	Carboxylesterase family protein	0.0063	0.0897	0.1003
Onchocerca volvulus		0.0063	0.0897	0.4177
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0033	0.0409	0.1608
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0051	0.0041
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0051	0.0051
Onchocerca volvulus		0.001	0.0051	0.0096
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0559	0.8803	1
Schistosoma mansoni	hypothetical protein	0.0156	0.2372	0.2372
Schistosoma mansoni	opsin-like receptor	0.0009	0.0031	0.0031
Plasmodium vivax	vivapain-1	0.0062	0.0874	0.501
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.1556	0.3139
Leishmania major	cathepsin L-like protease	0.0105	0.1556	0.4854
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0457	0.0457
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0031	0.0031
Onchocerca volvulus		0.0093	0.137	0.646
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.0041
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0033	0.0409	0.1608
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0033	0.0409	0.0449
Echinococcus multilocularis	sex peptide receptor	0.0009	0.0031	0.0031
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0189	0.0189
Entamoeba histolytica	cysteine protease, putative	0.0062	0.0874	0.1573
Brugia malayi	nuclear receptor NHR-88	0.001	0.0051	0.0041
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.0041
Onchocerca volvulus		0.0075	0.1091	0.5116
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0009	0.0031	0.0031
Giardia lamblia	Fructose-bisphosphate aldolase	0.0292	0.4543	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.1556	0.3139
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0409	0.0449
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0898	0.1006
Loa Loa (eye worm)	MH2 domain-containing protein	0.0115	0.1722	0.1943
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0189	0.0189
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0196	0.3005	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0031	0.0031
Echinococcus granulosus	neuropeptide FF receptor 2	0.0009	0.0031	0.0031
Brugia malayi	steroid hormone receptor	0.001	0.0051	0.0041
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0033	0.0409	0.0505
Brugia malayi	RNA binding protein	0.0063	0.0898	0.1006
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0009	0.0031	0.0031
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0652	0.0652
Brugia malayi	Melatonin receptor type 1A	0.0009	0.0031	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.1556	0.3139
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0409	0.0505
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0898	0.0898
Echinococcus multilocularis	cathepsin L cysteine protease	0.0105	0.1556	0.1556
Onchocerca volvulus		0.0033	0.0409	0.1825
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0105	0.1556	0.3139
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0063	0.0897	0.0897
Echinococcus granulosus	cysteine protease	0.0062	0.0874	0.0874
Echinococcus granulosus	7TM GPCR rhodopsin	0.0009	0.0031	0.0031
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0051	0.0051
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0457	0.095
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0075	0.1091	0.1047
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.4543	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0189	0.0199
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.1556	0.3139
Schistosoma mansoni	neuropeptide receptor	0.0009	0.0031	0.0031
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0898	0.1006
Toxoplasma gondii	cathepsin B	0.0196	0.3005	1
Echinococcus multilocularis	neuropeptide receptor	0.0009	0.0031	0.0031
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0031	0.0031
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0292	0.4543	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0031	0.0031
Echinococcus granulosus	somatostatin receptor	0.0009	0.0031	0.0031
Plasmodium vivax	vivapain-2	0.0105	0.1556	1
Entamoeba histolytica	cysteine protease, putative	0.0062	0.0874	0.1573
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0897	0.1003
Brugia malayi	hypothetical protein	0.0009	0.0031	0.0018
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0063	0.0897	0.0897
Onchocerca volvulus	Cathepsin L homolog	0.0105	0.1556	0.7359
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0051	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0409	0.0449
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0898	0.0898
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0457	0.0614
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0033	0.0409	0.0505
Loa Loa (eye worm)	G-protein coupled receptor	0.0009	0.0031	0.0018
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0051	0.0051
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0033	0.0409	0.0409
Echinococcus multilocularis	geminin	0.0156	0.2372	0.2372
Entamoeba histolytica	cysteine proteinase, putative	0.0105	0.1556	0.3139
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0033	0.0409	0.0505
Echinococcus multilocularis	neuropeptides capa receptor	0.0009	0.0031	0.0031
Echinococcus multilocularis	neuropeptide receptor	0.0009	0.0031	0.0031
Echinococcus multilocularis	neuropeptide Y receptor	0.0009	0.0031	0.0031
Entamoeba histolytica	cysteine proteinase, putative	0.0105	0.1556	0.3139
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0009	0.0031	0.0018
Brugia malayi	Papain family cysteine protease containing protein	0.0105	0.1556	0.1754
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	0.1091	0.2071
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0009	0.0031	0.0018
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0051	0.0051
Schistosoma mansoni	tyrosinase precursor	0.0093	0.137	0.137
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0409	0.0505
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.0041
Echinococcus granulosus	cathepsin L	0.0062	0.0874	0.0874
Brugia malayi	putative neuropeptide receptor NPR1	0.0009	0.0031	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0409	0.0505
Entamoeba histolytica	cysteine proteinase, putative	0.0062	0.0874	0.1573
Trypanosoma cruzi	cysteine peptidase, putative	0.0105	0.1556	0.1587
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0009	0.0031	0.0031
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0105	0.1556	0.4854
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0051	0.0051
Schistosoma mansoni	cpg binding protein	0.0029	0.0358	0.0358
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0015	0.0015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0033	0.0409	0.0505
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0033	0.0409	0.1608
Entamoeba histolytica	cysteine proteinase 2	0.0062	0.0874	0.1573
Schistosoma mansoni	neuropeptide receptor	0.0009	0.0031	0.0031
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0105	0.1556	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0046	0.063	0.07
Toxoplasma gondii	cathepsin CPC1	0.0033	0.0409	0.078
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0033	0.0409	0.0449
Giardia lamblia	Cysteine protease	0.0033	0.0409	0.0505
Giardia lamblia	Cathepsin B precursor	0.0196	0.3005	0.6467
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0009	0.0031	0.0018
Echinococcus granulosus	tm gpcr rhodopsin	0.0009	0.0031	0.0031
Echinococcus multilocularis	acetylcholinesterase	0.0374	0.5848	0.5848
Plasmodium falciparum	serine repeat antigen 6	0.0033	0.0409	0.1608
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0409	0.0505
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0898	0.0898
Onchocerca volvulus	Cathepsin L homolog	0.0033	0.0409	0.1825
Brugia malayi	Dopamine receptor protein 1	0.0009	0.0031	0.0018
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0009	0.0031	0.0031
Loa Loa (eye worm)	ctsf protein	0.0105	0.1556	0.1754
Trypanosoma cruzi	cysteine peptidase, putative	0.0105	0.1556	0.1587
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0031	0.0031
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0009	0.0031	0.0031
Echinococcus multilocularis	cathepsin L	0.0033	0.0409	0.0409
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0009	0.0031	0.0031
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1091	0.1225
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0051	0.0041
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.1556	0.3139
Echinococcus granulosus	Smad4	0.0008	0.0015	0.0015
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0009	0.0031	0.0031
Entamoeba histolytica	cysteine protease, putative	0.0062	0.0874	0.1573
Schistosoma mansoni	cathepsin F (C01 family)	0.0105	0.1556	0.1556
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0105	0.1556	0.1556
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0009	0.0031	0.0031
Schistosoma mansoni	hypothetical protein	0.0009	0.0031	0.0031
Giardia lamblia	Cathepsin B precursor	0.0033	0.0409	0.0505
Echinococcus granulosus	cathepsin b	0.0559	0.8803	0.8803
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0031	0.0031
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0093	0.137	0.1542
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0409	0.0505
Brugia malayi	AKH receptor	0.0009	0.0031	0.0018
Schistosoma mansoni	cathepsin C	0.0033	0.0409	0.0409
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0409	0.0449
Schistosoma mansoni	gliotactin	0.0063	0.0897	0.0897
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0051	0.0051
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0062	0.0874	0.0874
Brugia malayi	GnHR receptor homolog	0.0009	0.0031	0.0018
Schistosoma mansoni	survival motor neuron protein	0.0046	0.063	0.063
Leishmania major	cathepsin L-like protease	0.0105	0.1556	0.4854
Echinococcus granulosus	survival motor neuron protein 1	0.0228	0.3519	0.3519
Schistosoma mansoni	amine GPCR	0.0009	0.0031	0.0031
Giardia lamblia	Cathepsin L precursor	0.0033	0.0409	0.0505
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0015	0.0015
Loa Loa (eye worm)	cysteine protease	0.0105	0.1556	0.1754
Schistosoma mansoni	hypothetical protein	0.0046	0.063	0.063
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.0409	0.0449
Echinococcus granulosus	neuroligin	0.0063	0.0897	0.0897
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0033	0.0409	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0033	0.0409	0.0449
Echinococcus multilocularis	cysteine protease	0.0105	0.1556	0.1556
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0051	0.0051
Echinococcus multilocularis	neuropeptides capa receptor	0.0009	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0897	0.1003
Brugia malayi	nuclear hormone receptor	0.001	0.0051	0.0041
Brugia malayi	cathepsin L precursor	0.0033	0.0409	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0051	0.0041
Entamoeba histolytica	cysteine protease, putative	0.0062	0.0874	0.1573
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0051	0.0041
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0457	0.0457
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.1556	0.3139
Giardia lamblia	Cathepsin B precursor	0.0033	0.0409	0.0505
Echinococcus multilocularis	G protein coupled receptor 139	0.0009	0.0031	0.0031
Plasmodium falciparum	serine repeat antigen 2	0.0033	0.0409	0.1608
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Brugia malayi	cathepsin L-like cysteine proteinase	0.0033	0.0409	0.0449
Schistosoma mansoni	amine GPCR	0.0009	0.0031	0.0031
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0559	0.8803	0.8803
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0031	0.0031
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0189	0.0199
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0009	0.0031	0.0031
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0051	0.0051
Giardia lamblia	Cathepsin L precursor	0.0033	0.0409	0.0505
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0051	0.0041
Plasmodium falciparum	serine repeat antigen 7	0.0033	0.0409	0.1608
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0033	0.0409	0.0505
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0874	0.2432
Loa Loa (eye worm)	cathepsin B	0.0196	0.3005	0.3403
Brugia malayi	Cathepsin L-like precursor	0.0075	0.1091	0.1225
Onchocerca volvulus		0.0063	0.0897	0.4177
Brugia malayi	hypothetical protein	0.0009	0.0031	0.0018
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0105	0.1556	0.3139
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Brugia malayi	hypothetical protein	0.0009	0.0031	0.0018
Echinococcus granulosus	g protein coupled receptor	0.0009	0.0031	0.0031
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0009	0.0031	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0409	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0355	0.0387
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0015	0.0015
Echinococcus granulosus	geminin	0.0156	0.2372	0.2372
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0652	0.0652
Plasmodium vivax	vivapain-2	0.0105	0.1556	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0031	0.0031
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.4543	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0015	0.0015
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0105	0.1556	0.1754
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0033	0.0409	0.0449
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0009	0.0031	0.0031
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0063	0.0897	0.3583
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0033	0.0409	0.0409
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0033	0.0409	0.0505
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.4543	1
Leishmania major	cathepsin L-like protease	0.0105	0.1556	0.4854
Echinococcus multilocularis	acetylcholinesterase	0.0374	0.5848	0.5848
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0009	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0897	0.1003
Schistosoma mansoni	ap endonuclease	0.0019	0.0189	0.0189
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0031	0.0031
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0033	0.0409	0.0409
Onchocerca volvulus		0.0105	0.1556	0.7359
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0009	0.0031	0.0031
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0105	0.1556	0.4854
Trichomonas vaginalis	spcc417.12 protein, putative	0.0063	0.0897	0.1624
Echinococcus multilocularis	neuropeptide s receptor	0.0009	0.0031	0.0031
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0051	0.0051
Loa Loa (eye worm)	inositol-1	0.0036	0.0457	0.0503
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0457	0.0457
Schistosoma mansoni	hypothetical protein	0.0009	0.0031	0.0031
Loa Loa (eye worm)	fibroinase	0.0105	0.1556	0.1754
Schistosoma mansoni	cpg binding protein	0.0028	0.0333	0.0333
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0143	0.2163	1
Echinococcus granulosus	cathepsin l1	0.0075	0.1091	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0051	0.0051
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0457	0.0614
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0031	0.0031
Treponema pallidum	fructose-bisphosphate aldolase	0.0292	0.4543	1
Entamoeba histolytica	cysteine protease, putative	0.0062	0.0874	0.1573
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0093	0.137	0.1542
Brugia malayi	ecdysteroid receptor	0.001	0.0051	0.0041
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0033	0.0409	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0105	0.1556	0.4854
Echinococcus multilocularis	smad	0.0008	0.0015	0.0015
Entamoeba histolytica	cysteine protease, putative	0.0062	0.0874	0.1573
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0105	0.1556	0.1556
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0033	0.0409	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0031	0.0031
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0009	0.0031	0.0018
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0029	0.0355	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0897	0.1003
Brugia malayi	Carboxylesterase family protein	0.0374	0.5848	0.6637
Leishmania major	cathepsin L-like protease	0.0105	0.1556	0.4854
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0898	0.0898
Echinococcus multilocularis	dnaJ subfamily B	0.0396	0.6203	0.6203
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0457	0.0457
Trypanosoma cruzi	cruzipain precursor, putative	0.0029	0.0355	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0374	0.5848	0.6637
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.1556	0.3139
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1091	0.1225
Entamoeba histolytica	cysteine protease, putative	0.0062	0.0874	0.1573
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.4543	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0009	0.0031	0.0031
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0559	0.8803	0.8803
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Brugia malayi	hypothetical protein	0.0009	0.0031	0.0018
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0009	0.0031	0.0031
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0457	0.1355
Echinococcus granulosus	neuropeptides capa receptor	0.0009	0.0031	0.0031
Leishmania major	cathepsin L-like protease	0.0105	0.1556	0.4854
Entamoeba histolytica	cysteine protease, putative	0.0062	0.0874	0.1573
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0409	0.0505
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0051	0.0041
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0105	0.1556	0.4854
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0062	0.0874	0.0874
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.083	0.083
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0105	0.1556	0.3139
Echinococcus granulosus	allatostatin A receptor	0.0009	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.0041
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0009	0.0031	0.0031
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Plasmodium falciparum	serine repeat antigen 1	0.0033	0.0409	0.1608
Brugia malayi	hypothetical protein	0.0063	0.0897	0.1003
Entamoeba histolytica	cysteine proteinase, putative	0.0062	0.0874	0.1573
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.0041
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0292	0.4543	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Entamoeba histolytica	cysteine protease, putative	0.0062	0.0874	0.1573
Onchocerca volvulus		0.0028	0.0333	0.1459
Brugia malayi	G protein-coupled receptor	0.0009	0.0031	0.0018
Brugia malayi	Carboxylesterase family protein	0.0374	0.5848	0.6637
Schistosoma mansoni	tyrosinase precursor	0.0093	0.137	0.137
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Trypanosoma cruzi	cysteine protease, putative	0.0062	0.0874	0.0795
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0093	0.137	0.1542
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0051	0.0041
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0652	0.0652
Loa Loa (eye worm)	carboxylesterase	0.0063	0.0897	0.1003
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.0409	0.0449
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0409	0.0505
Plasmodium vivax	vivapain-3	0.0062	0.0874	0.501
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.1556	0.3139
Entamoeba histolytica	hypothetical protein	0.0033	0.0409	0.0505
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.1556	0.3139
Brugia malayi	Common central domain of tyrosinase family protein	0.0093	0.137	0.1542
Echinococcus multilocularis	neuroligin	0.0063	0.0897	0.0897
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0196	0.3005	1
Echinococcus granulosus	orexin receptor type 2	0.0009	0.0031	0.0031
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0033	0.0409	0.1608
Echinococcus granulosus	cpg binding protein	0.0029	0.0358	0.0358
Echinococcus granulosus	tm gpcr rhodopsin	0.0009	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0897	0.1003
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0009	0.0031	0.0031
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0033	0.0409	0.0449
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0009	0.0031	0.0031
Onchocerca volvulus		0.0139	0.2104	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0051	0.0041
Echinococcus granulosus	para nitrobenzyl esterase	0.0063	0.0897	0.0897
Trypanosoma cruzi	cysteine proteinase, putative	0.0062	0.0874	0.0795
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.0409	0.0449
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0009	0.0031	0.0031
Brugia malayi	follicle stimulating hormone receptor	0.0009	0.0031	0.0018
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0033	0.0409	0.1608
Brugia malayi	Cathepsin L-like precursor	0.0105	0.1556	0.1754
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0033	0.0409	0.0505
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.073	0.1919
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0559	0.8803	0.8803
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0033	0.0409	0.0449
Brugia malayi	hypothetical protein	0.0009	0.0031	0.0018
Brugia malayi	fibroinase precursor	0.0033	0.0409	0.0449
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0033	0.0409	0.1608
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0009	0.0031	0.0018
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0009	0.0031	0.0031
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0033	0.0409	0.0505
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0009	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0374	0.5848	0.5848
Echinococcus multilocularis	serotonin receptor	0.0009	0.0031	0.0031
Trypanosoma cruzi	cruzipain precursor, putative	0.0105	0.1556	0.1587
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0063	0.0897	0.0897
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0559	0.8803	0.8803
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0015	0.0015
Leishmania major	cathepsin L-like protease	0.0105	0.1556	0.4854
Echinococcus granulosus	sex peptide receptor	0.0009	0.0031	0.0031
Brugia malayi	hypothetical protein	0.0139	0.2104	0.2377
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0033	0.0409	0.0505
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0105	0.1556	0.4854
Plasmodium vivax	serine-repeat antigen (SERA)	0.0033	0.0409	0.1608
Echinococcus multilocularis	g protein coupled receptor	0.0009	0.0031	0.0031
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0652	0.0725
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0105	0.1556	0.3139
Brugia malayi	G protein-coupled receptor F59B2.13	0.0009	0.0031	0.0018
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0033	0.0409	0.0505
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	0.1091	0.2071
Loa Loa (eye worm)	hypothetical protein	0.0093	0.137	0.1542
Echinococcus multilocularis	para nitrobenzyl esterase	0.0063	0.0897	0.0897
Echinococcus granulosus	dro:myosuppressin receptor	0.0009	0.0031	0.0031
Loa Loa (eye worm)	tyrosinase 1	0.0093	0.137	0.1542
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0063	0.0897	0.0897
Giardia lamblia	Cathepsin L-like protease	0.0033	0.0409	0.0505
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0031	0.0031
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0409	0.0505
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0457	0.0614
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0105	0.1556	0.4854
Brugia malayi	hypothetical protein	0.0009	0.0031	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Schistosoma mansoni	cathepsin B (C01 family)	0.0033	0.0409	0.0409
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0051	0.0051
Echinococcus granulosus	cathepsin b	0.0559	0.8803	0.8803
Brugia malayi	hypothetical protein	0.0009	0.0031	0.0018
Echinococcus multilocularis	somatostatin receptor	0.0009	0.0031	0.0031
Schistosoma mansoni	biogenic amine receptor	0.0009	0.0031	0.0031
Brugia malayi	Cathepsin L-like precursor	0.0105	0.1556	0.1754
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0105	0.1556	0.3139
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0009	0.0031	0.0031
Trypanosoma cruzi	cysteine proteinase, putative	0.0062	0.0874	0.0795
Onchocerca volvulus		0.0063	0.0897	0.4177
Brugia malayi	Carboxylesterase family protein	0.0063	0.0897	0.1003
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0031	0.0031
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0009	0.0031	0.0031
Leishmania major	cathepsin L-like protease	0.0105	0.1556	0.4854
Onchocerca volvulus		0.0105	0.1556	0.7359
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0898	0.1006
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0033	0.0409	0.0505
Schistosoma mansoni	histamine h1 receptor	0.0009	0.0031	0.0031
Echinococcus granulosus	neuropeptide Y receptor	0.0009	0.0031	0.0031
Giardia lamblia	Cathepsin B precursor	0.0033	0.0409	0.0505
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0062	0.0874	0.0795
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0009	0.0031	0.0018
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0051	0.0041
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0105	0.1556	0.1754
Brugia malayi	cathepsin F-like cysteine proteinase	0.0029	0.0355	0.0387
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.4543	1
Schistosoma mansoni	hypothetical protein	0.0396	0.6203	0.6203
Schistosoma mansoni	coup transcription factor	0.001	0.0051	0.0051
Schistosoma mansoni	amine GPCR	0.0009	0.0031	0.0031
Echinococcus granulosus	smad	0.0008	0.0015	0.0015
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0105	0.1556	0.4854
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0033	0.0409	0.0409
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0051	0.0051
Brugia malayi	MH2 domain containing protein	0.0115	0.1722	0.1943
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0051	0.0041
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0652	0.0725
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0033	0.0409	0.0505
Entamoeba histolytica	cysteine protease, putative	0.0062	0.0874	0.1573
Echinococcus multilocularis	cathepsin L	0.0062	0.0874	0.0874
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0033	0.0409	0.1608
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0063	0.0897	0.0897
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0009	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0009	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1091	0.1225
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0874	0.0795
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.4543	1
Echinococcus multilocularis	g protein coupled receptor	0.0009	0.0031	0.0031
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0105	0.1556	0.1556
Echinococcus multilocularis	survival motor neuron protein 1	0.0228	0.3519	0.3519
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.1556	0.3139
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0009	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Echinococcus granulosus	cathepsin l1	0.0105	0.1556	0.1556
Loa Loa (eye worm)	hypothetical protein	0.0139	0.2104	0.2377
Schistosoma mansoni	amine GPCR	0.0009	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Echinococcus granulosus	acetylcholinesterase	0.0374	0.5848	0.5848
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Trypanosoma cruzi	cysteine peptidase, putative	0.0105	0.1556	0.1587
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0051	0.0051
Onchocerca volvulus		0.0105	0.1556	0.7359
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0031	0.0031
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0009	0.0031	0.0031
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0009	0.0031	0.0018
Giardia lamblia	Cathepsin L precursor	0.0033	0.0409	0.0505
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0374	0.5848	0.6637
Mycobacterium ulcerans	carboxylesterase, LipT	0.0063	0.0897	0.3583
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0009	0.0031	0.0031
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0652	0.0652
Schistosoma mansoni	microtubule-associated protein tau	0.0635	1	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0033	0.0409	0.1608
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0051	0.0041
Echinococcus multilocularis	microtubule associated protein 2	0.0635	1	1
Brugia malayi	ORL1-like opioid receptor	0.0009	0.0031	0.0018
Onchocerca volvulus		0.0063	0.0897	0.4177
Echinococcus granulosus	neuropeptide receptor	0.0009	0.0031	0.0031
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0031	0.0031
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0033	0.0409	0.0409
Onchocerca volvulus		0.0093	0.137	0.646
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0009	0.0031	0.0031
Brugia malayi	Dopamine receptor protein 2	0.0009	0.0031	0.0018
Echinococcus granulosus	BC026374 protein S09 family	0.0063	0.0897	0.0897
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0105	0.1556	0.4854
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0897	0.1003
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0033	0.0409	0.0409
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0051	0.0051
Echinococcus granulosus	7tm_1 domain containing protein	0.0009	0.0031	0.0031
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0062	0.0874	0.0874
Brugia malayi	Cathepsin L-like precursor	0.0105	0.1556	0.1754
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Giardia lamblia	Cathepsin L-like protease	0.0033	0.0409	0.0505
Loa Loa (eye worm)	carboxylesterase	0.0063	0.0897	0.1003
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0033	0.0409	0.1608
Loa Loa (eye worm)	acetylcholinesterase 1	0.0374	0.5848	0.6637
Brugia malayi	F/Y-rich N-terminus family protein	0.0008	0.0025	0.0012
Giardia lamblia	Encystation-specific protease	0.0033	0.0409	0.0505
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.1556	0.3139
Schistosoma mansoni	neuropeptide F-like receptor	0.0009	0.0031	0.0031
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0027	0.0027
Brugia malayi	hypothetical protein	0.0228	0.3519	0.3987
Echinococcus multilocularis	allatostatin A receptor	0.0009	0.0031	0.0031
Onchocerca volvulus		0.0105	0.1556	0.7359
Entamoeba histolytica	cysteine protease, putative	0.0062	0.0874	0.1573
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0063	0.0897	0.3583
Brugia malayi	cathepsin B-like cysteine proteinase	0.0559	0.8803	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0105	0.1556	0.1556
Echinococcus multilocularis	cpg binding protein	0.0029	0.0358	0.0358
Loa Loa (eye worm)	transcription factor SMAD2	0.0115	0.1722	0.1943
Schistosoma mansoni	growth hormone secretagogue receptor	0.0009	0.0031	0.0031
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0009	0.0031	0.0031
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0033	0.0409	0.1608
Giardia lamblia	Cathepsin L precursor	0.0033	0.0409	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0409	0.0505
Brugia malayi	G-protein coupled receptor	0.0009	0.0031	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0409	0.0505
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0051	0.0096
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0033	0.0409	0.1608
Onchocerca volvulus		0.0105	0.1556	0.7359
Loa Loa (eye worm)	TYRA-2 protein	0.0009	0.0031	0.0018
Giardia lamblia	Cathepsin B precursor	0.0033	0.0409	0.0505
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0062	0.0874	0.1573
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0898	0.0898
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0409	0.0449
Brugia malayi	Cathepsin L-like precursor	0.0075	0.1091	0.1225
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0051	0.0041
Giardia lamblia	Hypothetical protein	0.0033	0.0409	0.0505
Schistosoma mansoni	cathepsin S (C01 family)	0.0033	0.0409	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0051	0.0051
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0051	0.0041
Brugia malayi	ShTK domain containing protein	0.0093	0.137	0.1542
Brugia malayi	Inositol-1	0.0036	0.0457	0.0503
Onchocerca volvulus		0.0093	0.137	0.646
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0105	0.1556	1
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0333	0.0362
Onchocerca volvulus	Cathepsin F homolog	0.0105	0.1556	0.7359
Brugia malayi	TAR-binding protein	0.0063	0.0898	0.1006
Leishmania major	cathepsin L-like protease	0.0105	0.1556	0.4854
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0009	0.0031	0.0031
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0027	0.0014
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0457	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0051	0.0051
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0333	0.0362
Echinococcus granulosus	biogenic amine 5HT receptor	0.0009	0.0031	0.0031
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0051	0.0041
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0652	0.0652
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0033	0.0409	0.0505
Entamoeba histolytica	cysteine protease, putative	0.0062	0.0874	0.1573
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0196	0.3005	0.3005
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Schistosoma mansoni	opsin-like receptor	0.0009	0.0031	0.0031
Brugia malayi	Papain family cysteine protease containing protein	0.0062	0.0874	0.0978
Echinococcus multilocularis	Smad4	0.0008	0.0015	0.0015
Echinococcus granulosus	neuropeptide Y receptor	0.0009	0.0031	0.0031
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Echinococcus granulosus	G protein coupled receptor 139	0.0009	0.0031	0.0031
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0009	0.0031	0.0031
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.1556	0.3139
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0874	0.2432
Giardia lamblia	Cathepsin L precursor	0.0033	0.0409	0.0505
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0355	0.0387
Schistosoma mansoni	adenoreceptor	0.0009	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0063	0.0897	0.1624
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0033	0.0409	0.078
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0457	0.095
Brugia malayi	Papain family cysteine protease containing protein	0.0062	0.0874	0.0978
Entamoeba histolytica	cysteine proteinase, putative	0.0062	0.0874	0.1573
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0009	0.0031	0.0031
Schistosoma mansoni	opsin-like receptor	0.0009	0.0031	0.0031
Schistosoma mansoni	biogenic amine receptor	0.0009	0.0031	0.0031
Echinococcus granulosus	tm gpcr rhodopsin	0.0009	0.0031	0.0031
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0015	0.0015
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.4543	1
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.0397	0.1054
Echinococcus multilocularis	g protein coupled receptor	0.0009	0.0031	0.0031
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0031	0.0031
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0051	0.0041
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0051	0.0051
Brugia malayi	Serotonin receptor	0.0009	0.0031	0.0018
Plasmodium falciparum	serine repeat antigen 9	0.0033	0.0409	0.1608
Plasmodium falciparum	serine repeat antigen 5	0.0033	0.0409	0.1608
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0009	0.0031	0.0031
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0105	0.1556	1
Echinococcus granulosus	cathepsin L	0.0033	0.0409	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0409	0.0449
Giardia lamblia	Cysteine protease	0.0033	0.0409	0.0505
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0009	0.0031	0.0018
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0051	0.0051
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0063	0.0897	0.0897
Schistosoma mansoni	smad	0.0008	0.0015	0.0015
Brugia malayi	larval opioid receptor	0.0009	0.0031	0.0018
Echinococcus multilocularis	orexin receptor type 2	0.0009	0.0031	0.0031
Schistosoma mansoni	cathepsin F (C01 family)	0.0075	0.1091	0.1091
Onchocerca volvulus		0.0105	0.1556	0.7359
Echinococcus multilocularis	neuropeptide receptor A26	0.0009	0.0031	0.0031
Brugia malayi	Serotonin receptor	0.0009	0.0031	0.0018
Echinococcus multilocularis	fmrfamide receptor	0.0009	0.0031	0.0031
Echinococcus granulosus	carboxylesterase 5A	0.0374	0.5848	0.5848
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0457	0.095
Echinococcus granulosus	g protein coupled receptor	0.0009	0.0031	0.0031
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0009	0.0031	0.0018
Echinococcus granulosus	serotonin receptor	0.0009	0.0031	0.0031
Giardia lamblia	Cathepsin L precursor	0.0033	0.0409	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Echinococcus granulosus	neuropeptide receptor A26	0.0009	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0063	0.0897	0.3583
Echinococcus granulosus	hypothetical protein	0.0009	0.0031	0.0031
Onchocerca volvulus		0.0093	0.137	0.646
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0051	0.0051
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0051	0.0041
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0031	0.0031
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0062	0.0874	0.1573
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0009	0.0031	0.0031
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0033	0.0409	0.0505
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0409	0.0505
Echinococcus multilocularis	fmrfamide receptor	0.0009	0.0031	0.0031
Entamoeba histolytica	cysteine protease, putative	0.0062	0.0874	0.1573
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0033	0.0409	0.1608
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0009	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0897	0.1003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0031	0.0031
Schistosoma mansoni	neuropeptide receptor	0.0009	0.0031	0.0031
Giardia lamblia	Cysteine protease	0.0033	0.0409	0.0505
Echinococcus granulosus	g protein coupled receptor	0.0009	0.0031	0.0031
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0051	0.0051
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0051	0.0051
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0457	0.0614
Echinococcus multilocularis	g-protein coupled receptor	0.0009	0.0031	0.0031
Giardia lamblia	Cathepsin B precursor	0.0033	0.0409	0.0505
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0009	0.0031	0.0031
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0033	0.0409	0.1608
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0457	0.031
Plasmodium vivax	unspecified product	0.0029	0.0355	0.1212
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0409	0.0505
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0051	0.0051
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0051	0.0041
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0009	0.0031	0.0031
Giardia lamblia	Hypothetical protein	0.0033	0.0409	0.0505
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0105	0.1556	0.3139
Brugia malayi	putative neuropeptide receptor	0.0009	0.0031	0.0018
Trypanosoma cruzi	cysteine peptidase, putative	0.0029	0.0355	0.0192
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0031	0.0031
Brugia malayi	hypothetical protein	0.0009	0.0031	0.0018
Echinococcus granulosus	neuropeptide s receptor	0.0009	0.0031	0.0031
Brugia malayi	Cathepsin L-like precursor	0.0105	0.1556	0.1754
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0105	0.1556	0.4854
Schistosoma mansoni	neuropeptide receptor	0.0009	0.0031	0.0031
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0075	0.1091	0.1225
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0051	0.0041
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0196	0.3005	0.6467
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0051	0.0041
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.0041
Plasmodium falciparum	serine repeat antigen 4	0.0033	0.0409	0.1608
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0062	0.0874	0.501
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0105	0.1556	0.3139
Loa Loa (eye worm)	ShTK domain-containing protein	0.0093	0.137	0.1542
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0009	0.0031	0.0031
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.0409	0.0505
Brugia malayi	sulfakinin receptor protein	0.0009	0.0031	0.0018
Schistosoma mansoni	neuropeptide f receptor 76f	0.0009	0.0031	0.0031
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0031	0.0031
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0051	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0355	0.0387
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0652	0.0652
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0105	0.1556	0.1754
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0051	0.0051
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0009	0.0031	0.0031
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0031	0.0031
Brugia malayi	Dopamine receptor	0.0009	0.0031	0.0018
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0105	0.1556	0.4854
Entamoeba histolytica	cysteine proteinase, putative	0.0075	0.1091	0.2071
Entamoeba histolytica	cysteine proteinase, putative	0.0062	0.0874	0.1573
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0031	0.0031
Brugia malayi	Carboxylesterase family protein	0.0063	0.0897	0.1003
Echinococcus granulosus	neuropeptide receptor	0.0009	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0031	0.0018
Echinococcus multilocularis	neuropeptide Y receptor	0.0009	0.0031	0.0031
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0409	0.0505
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0029	0.0355	0.0387
Echinococcus granulosus	g-protein coupled receptor	0.0009	0.0031	0.0031
Schistosoma mansoni	cathepsin F (C01 family)	0.0105	0.1556	0.1556
Trypanosoma cruzi	major cysteine proteinase, putative	0.0033	0.0409	0.0255
Onchocerca volvulus		0.0046	0.063	0.2891
Echinococcus multilocularis	serotonin receptor	0.0009	0.0031	0.0031
Echinococcus multilocularis	carboxylesterase 5A	0.0374	0.5848	0.5848
Loa Loa (eye worm)	hypothetical protein	0.0228	0.3519	0.3987
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0105	0.1556	0.3139
Schistosoma mansoni	amine GPCR	0.0009	0.0031	0.0031
Loa Loa (eye worm)	G-protein coupled receptor	0.0009	0.0031	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0409	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0559	0.8803	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0409	0.0449

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 360 nM	Binding affinity for the Opioid receptor kappa 1	ChEMBL.	2832603
Ki (binding)	> 1000 nM	Binding affinity for the Opioid receptor mu 1	ChEMBL.	2832603

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL556802

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1048957