Detailed information for compound 1063190

Basic information

Technical information
  • TDR Targets ID: 1063190
  • Name: N-[2-(4-ethylpiperazine-1-carbonyl)phenyl]-4- methoxy-N-(phenylmethyl)benzenesulfonamide
  • MW: 493.618 | Formula: C27H31N3O4S
  • H donors: 0 H acceptors: 3 LogP: 3.73 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCN(CC1)C(=O)c1ccccc1N(S(=O)(=O)c1ccc(cc1)OC)Cc1ccccc1
  • InChi: 1S/C27H31N3O4S/c1-3-28-17-19-29(20-18-28)27(31)25-11-7-8-12-26(25)30(21-22-9-5-4-6-10-22)35(32,33)24-15-13-23(34-2)14-16-24/h4-16H,3,17-21H2,1-2H3
  • InChiKey: NGTPUUSEYLJISM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[(4-ethyl-1-piperazinyl)-oxomethyl]phenyl]-4-methoxy-N-(phenylmethyl)benzenesulfonamide
  • N-(benzyl)-N-[2-(4-ethylpiperazine-1-carbonyl)phenyl]-4-methoxy-benzenesulfonamide
  • N-[2-(4-ethylpiperazin-1-yl)carbonylphenyl]-4-methoxy-N-(phenylmethyl)benzenesulfonamide
  • STK140301
  • MLS000693528
  • N-benzyl-N-{2-[(4-ethyl-1-piperazinyl)carbonyl]phenyl}-4-methoxybenzenesulfonamide
  • SMR000300254

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0001 0.0004
Leishmania major heat shock protein 83-1 0.0035 0.0009 0.0022
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0012 0.0106
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1376 0.0755 0.217
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.0092 0.0091
Echinococcus granulosus lysosomal alpha glucosidase 0.0185 0.0092 0.0091
Echinococcus granulosus cpg binding protein 0.0031 0.0006 0.0006
Entamoeba histolytica hypothetical protein 0.0298 0.0155 0.1484
Leishmania major heat shock protein 83-1 0.0035 0.0009 0.0022
Loa Loa (eye worm) cytochrome P450 0.004 0.0011 0.0071
Loa Loa (eye worm) hypothetical protein 0.0049 0.0016 0.0103
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.0046 0.0259
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0049 0.0016 0.0089
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0024 0.032
Loa Loa (eye worm) phosphatidylinositol 3 0.0298 0.0155 0.0976
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0009 0.0008
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.189 0.1042 0.2994
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.004 0.0011 0.0031
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.004 0.0011 0.0803
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.004 0.0011 0.0142
Echinococcus multilocularis lysine specific demethylase 5A 0.0185 0.0092 0.0091
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.004 0.0011 0.0684
Schistosoma mansoni hypothetical protein 0.0077 0.0032 0.0176
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0792 0.043 0.4127
Giardia lamblia Heat shock protein HSP 90-alpha 0.0035 0.0009 0.0105
Schistosoma mansoni rab6-interacting 0.0022 0.0001 0.0003
Leishmania major phosphatidylinositol 3-kinase, putative 0.1338 0.0734 0.2012
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0009 0.0008
Schistosoma mansoni patched 1 0.0044 0.0013 0.0071
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0046 0.0045
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0257 0.0132 0.1776
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0006 0.0032
Echinococcus granulosus expressed conserved protein 0.0096 0.0042 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.1353 0.0743 0.7126
Trypanosoma brucei heat shock protein, putative 0.0035 0.0009 0.0105
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.136 0.0747 0.2047
Loa Loa (eye worm) hypothetical protein 0.0561 0.0301 0.1895
Trichomonas vaginalis PIKK family atypical protein kinase 0.1353 0.0743 0.7126
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.004 0.0011 0.0684
Echinococcus granulosus survival motor neuron protein 1 0.051 0.0273 0.0272
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0005 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.1346 0.0739 0.7089
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.189 0.1042 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0792 0.043 0.4125
Brugia malayi cytochrome P450 0.004 0.0011 0.0101
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0012 0.003
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0001 0.0001
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0089 0.0038 0.15
Echinococcus multilocularis lysine specific demethylase 6a 0.0049 0.0016 0.0016
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.0092 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.1353 0.0743 0.7126
Mycobacterium leprae Conserved hypothetical protein 0.004 0.0011 0.0445
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.004 0.0011 0.0803
Brugia malayi FAT domain containing protein 0.0561 0.0301 0.2888
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0009 0.0077
Echinococcus multilocularis protein patched 0.0044 0.0013 0.0013
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0104 0.0047 0.0443
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0088 0.0038 0.1476
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0051 0.0017 0.0017
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0013 0.0013
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0009 0.0105
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0131 0.0062 0.0168
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0472 0.0252 0.1582
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.004 0.0011 0.0803
Echinococcus multilocularis microtubule associated protein 2 0.2211 0.122 0.122
Echinococcus multilocularis 0.0298 0.0155 0.0155
Echinococcus multilocularis RUN 0.0022 0.0001 0.0001
Brugia malayi Cytochrome P450 family protein 0.006 0.0022 0.0208
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0298 0.0155 0.0445
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0001 0.0023
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0013 0.0083
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0062 0.4654
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.004 0.0011 0.0803
Leishmania major heat shock protein 83-1 0.0035 0.0009 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.004 0.0011 0.0684
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0001 0.0001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0044 0.0275
Loa Loa (eye worm) phosphatidylinositol 3 0.0298 0.0155 0.0976
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0792 0.043 0.5761
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1376 0.0755 0.0755
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.136 0.0747 0.7163
Trichomonas vaginalis PIKK family atypical protein kinase 0.1344 0.0738 0.708
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.1398 0.0768 0.7367
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0472 0.0252 0.241
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.0016 0.0103
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0298 0.0155 0.1484
Leishmania major cytochrome p450-like protein 0.006 0.0022 0.0059
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0298 0.0155 0.6158
Trichomonas vaginalis heat shock protein, putative 0.0022 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0489 0.0261 0.1644
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0009 0.0008
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.189 0.1042 1
Trypanosoma brucei heat shock protein, putative 0.0035 0.0009 0.0105
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.004 0.0011 0.0684
Brugia malayi hypothetical protein 0.051 0.0273 0.2613
Schistosoma mansoni hypothetical protein 0.0042 0.0012 0.0066
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0472 0.0252 0.0251
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0044 0.0243
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0788 0.0428 0.2414
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0472 0.0252 0.1419
Echinococcus multilocularis heat shock protein 90 0.0035 0.0009 0.0008
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.0062 0.0346
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0132 0.0063 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.1344 0.0738 0.708
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.0016 0.0103
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0044 0.0043
Brugia malayi Cytochrome P450 family protein 0.0126 0.0059 0.0564
Plasmodium vivax JmjC domain containing protein 0.0049 0.0016 0.0626
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.004 0.0011 0.0684
Loa Loa (eye worm) acetyltransferase 0.0298 0.0155 0.0973
Onchocerca volvulus 0.0154 0.0075 0.4764
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0788 0.0428 0.4101
Treponema pallidum heat shock protein 90 0.0028 0.0005 0.0293
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0257 0.0132 1
Leishmania major heat shock protein 83-1 0.0035 0.0009 0.0022
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0792 0.043 0.2429
Trichomonas vaginalis PIKK family atypical protein kinase 0.1345 0.0738 0.708
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.1285 0.0705 0.0704
Trichomonas vaginalis PIKK family atypical protein kinase 0.1351 0.0742 0.7117
Trichomonas vaginalis PIKK family atypical protein kinase 0.1338 0.0734 0.7043
Schistosoma mansoni cpg binding protein 0.003 0.0006 0.0027
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.3196 0.1769 1
Leishmania major hypothetical protein, conserved 0.0049 0.0016 0.0043
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0029 0.0005 0.004
Brugia malayi hypothetical protein 0.0125 0.0058 0.0554
Plasmodium falciparum JmjC domain-containing protein, putative 0.0049 0.0016 0.0626
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0131 0.0062 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0305 0.0159 0.1521
Trichomonas vaginalis PIKK family atypical protein kinase 0.1345 0.0738 0.708
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0009 0.0077
Schistosoma mansoni heat shock protein 0.0035 0.0009 0.0044
Echinococcus multilocularis phd:f box containing protein 0.0049 0.0016 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0044 0.0243
Schistosoma mansoni fkbp-rapamycin associated protein 0.0777 0.0422 0.2379
Loa Loa (eye worm) hypothetical protein 0.0298 0.0155 0.0976
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0472 0.0252 0.0688
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.004 0.0011 0.0684
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0257 0.0132 0.5
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0257 0.0132 0.8481
Echinococcus multilocularis peptidase Clp (S14 family) 0.0169 0.0083 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.1351 0.0742 0.7117
Trypanosoma brucei heat shock protein, putative 0.0035 0.0009 0.0105
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0298 0.0155 0.6158
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0012 0.0149
Toxoplasma gondii FATC domain-containing protein 0.0788 0.0428 0.5762
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0298 0.0155 0.2085
Echinococcus multilocularis heat shock protein 0.0035 0.0009 0.0008
Brugia malayi heat shock protein 90 0.0035 0.0009 0.0075
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0312 0.0163 0.2175
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0298 0.0155 0.2085
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.136 0.0747 0.4217
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0561 0.0301 0.0301
Schistosoma mansoni endoplasmin 0.0035 0.0009 0.0044
Loa Loa (eye worm) hypothetical protein 0.0049 0.0016 0.0103
Entamoeba histolytica acetyltransferase, GNAT family 0.008 0.0034 0.0317
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0792 0.043 0.4127
Trichomonas vaginalis PIKK family atypical protein kinase 0.136 0.0747 0.7163
Brugia malayi jmjC domain containing protein 0.0049 0.0016 0.0151
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0012 0.0106
Brugia malayi jmjC domain containing protein 0.0187 0.0093 0.0885
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.004 0.0011 0.0803
Plasmodium vivax hypothetical protein 0.0298 0.0155 0.6158
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0257 0.0132 0.5245
Onchocerca volvulus 0.0107 0.0048 0.3063
Leishmania major phosphatidylinositol kinase, putative 0.0298 0.0155 0.0424
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.189 0.1042 0.2994
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0088 0.0038 0.05
Trichomonas vaginalis PIKK family atypical protein kinase 0.079 0.0429 0.4116
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1285 0.0705 0.6759
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0009 0.0008
Echinococcus granulosus heat shock protein 0.0035 0.0009 0.0008
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0298 0.0155 0.2085
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.004 0.0011 0.0803
Leishmania major heat shock protein 83-1 0.0035 0.0009 0.0022
Echinococcus multilocularis jumonji domain containing 1A 0.0049 0.0016 0.0016
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0022 0.014
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0049 0.0016 0.0211
Loa Loa (eye worm) hypothetical protein 0.0859 0.0468 0.294
Brugia malayi Doublecortin family protein 0.0022 0.0001 0.0005
Echinococcus granulosus dnaJ subfamily B 0.0424 0.0225 0.0224
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.004 0.0011 0.0803
Entamoeba histolytica hypothetical protein 0.0298 0.0155 0.1484
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0049 0.0016 0.0046
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0298 0.0155 0.1484
Loa Loa (eye worm) CYP4Cod1 0.006 0.0022 0.014
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0009 0.0023
Giardia lamblia Histone acetyltransferase GCN5 0.008 0.0034 0.0442
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0006 0.0032
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0257 0.0132 0.5245
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0788 0.0428 0.5724
Leishmania major lanosterol 14-alpha-demethylase, putative 0.004 0.0011 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.079 0.0429 0.4116
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.189 0.1042 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.0016 0.0103
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.136 0.0747 0.2047
Leishmania major heat shock protein 83-1 0.0035 0.0009 0.0022
Trypanosoma cruzi heat shock protein 90, putative 0.0035 0.0009 0.0023
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.004 0.0011 0.0684
Echinococcus granulosus histone acetyltransferase KAT2B 0.0088 0.0038 0.0037
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0298 0.0155 0.0874
Schistosoma mansoni endoplasmin 0.0035 0.0009 0.0044
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0131 0.0062 0.0061
Echinococcus multilocularis endoplasmin 0.0028 0.0005 0.0004
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0257 0.0132 0.0132
Leishmania major cytochrome p450-like protein 0.004 0.0011 0.0029
Loa Loa (eye worm) hypothetical protein 0.0022 0.0001 0.0008
Trichomonas vaginalis bromodomain-containing protein, putative 0.0088 0.0038 0.0356
Toxoplasma gondii aldehyde dehydrogenase 0.0131 0.0062 0.0826
Trypanosoma cruzi heat shock protein 90, putative 0.0028 0.0005 0.0012
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0298 0.0155 0.2071
Schistosoma mansoni cytochrome P450 0.004 0.0011 0.006
Brugia malayi hypothetical protein 0.0154 0.0075 0.071
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.1345 0.0738 0.708
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0012 0.0106
Echinococcus granulosus phd:f box containing protein 0.0049 0.0016 0.0016
Giardia lamblia Phosphatidylinositol 4-kinase 0.0298 0.0155 0.2071
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0006 0.007
Schistosoma mansoni polycystin 1-related 0.0022 0.0001 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.004 0.0011 0.0684
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0472 0.0252 0.241
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.1285 0.0705 0.0704
Trichomonas vaginalis PIKK family atypical protein kinase 0.1351 0.0742 0.7117
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0006 0.0015
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0044 0.0413
Loa Loa (eye worm) phosphatidylinositol 3 0.0298 0.0155 0.0976
Mycobacterium leprae conserved hypothetical protein 0.0298 0.0155 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0052 0.0324
Trichomonas vaginalis PIKK family atypical protein kinase 0.136 0.0747 0.7163
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1353 0.0743 0.9948
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.004 0.0011 0.0803
Brugia malayi jmjC domain containing protein 0.0049 0.0016 0.0151
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0012 0.0011
Echinococcus granulosus heat shock protein 90 0.0028 0.0005 0.0004
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0792 0.043 0.1236
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.136 0.0747 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.3196 0.1769 0.1769
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0012 0.0106
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0009 0.0023
Schistosoma mansoni hypothetical protein 0.0424 0.0225 0.1269
Trichomonas vaginalis conserved hypothetical protein 0.0561 0.0301 0.2888
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0132 0.0063 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.1351 0.0742 0.7117
Brugia malayi Endoplasmin precursor 0.0035 0.0009 0.0075
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0001 0.0001
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.004 0.0011 0.0803
Echinococcus multilocularis protein dispatched 1 0.005 0.0017 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.004 0.0011 0.0684
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0185 0.0092 0.0091
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0785 0.0426 0.4085
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1376 0.0755 0.217
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0012 0.0032
Leishmania major heat shock protein 83-1 0.0035 0.0009 0.0022
Echinococcus granulosus neuropeptide s receptor 0.05 0.0268 0.0267
Loa Loa (eye worm) phosphatidylinositol 3 0.2875 0.1591 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.004 0.0011 0.0803
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0777 0.0422 0.0421
Mycobacterium leprae putative cytochrome p450 0.004 0.0011 0.0445
Schistosoma mansoni jumonji/arid domain-containing protein 0.0187 0.0093 0.0521
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0012 0.0074
Loa Loa (eye worm) hypothetical protein 0.0022 0.0001 0.0008
Schistosoma mansoni hypothetical protein 0.0042 0.0012 0.0066
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0298 0.0155 0.6158
Schistosoma mansoni phd/f-box containing protein 0.0049 0.0016 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0478 0.0255 0.2445
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0089 0.0038 0.2243
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.004 0.0011 0.0684
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.004 0.0011 0.0803
Schistosoma mansoni rab6-interacting 0.0022 0.0001 0.0003
Leishmania major heat shock protein 83-1 0.0035 0.0009 0.0022
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0257 0.0132 0.1776
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0298 0.0155 0.1484
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0472 0.0252 0.241
Loa Loa (eye worm) hypothetical protein 0.0025 0.0003 0.0017
Loa Loa (eye worm) hypothetical protein 0.0125 0.0058 0.0367
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0472 0.0252 0.0722
Trypanosoma brucei heat shock protein, putative 0.0035 0.0009 0.0105
Schistosoma mansoni alpha-glucosidase 0.0159 0.0077 0.0434
Schistosoma mansoni hypothetical protein 0.0042 0.0012 0.0066
Brugia malayi Glycosyl hydrolases family 31 protein 0.0185 0.0092 0.0875
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0257 0.0132 1
Giardia lamblia Grp94/Hsp90 0.0028 0.0005 0.0052
Schistosoma mansoni peptidase Clp (S14 family) 0.0257 0.0132 0.0744
Trypanosoma brucei Heat shock protein 83, putative 0.0035 0.0009 0.0105
Leishmania major phosphatidylinositol 4-kinase, putative 0.0298 0.0155 0.0424
Onchocerca volvulus Huntingtin homolog 0.0125 0.0058 0.3711
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.7971 1 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.004 0.0011 0.0684
Echinococcus granulosus lysine specific demethylase 6a 0.0049 0.0016 0.0016
Onchocerca volvulus Huntingtin homolog 0.0125 0.0058 0.3711
Trichomonas vaginalis PIKK family atypical protein kinase 0.0785 0.0426 0.4085
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0012 0.0106
Loa Loa (eye worm) hypothetical protein 0.0053 0.0019 0.0118
Loa Loa (eye worm) endoplasmin 0.0035 0.0009 0.0054
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.189 0.1042 1
Mycobacterium ulcerans heat shock protein 90 0.0028 0.0005 0.0293
Schistosoma mansoni hypothetical protein 0.0036 0.0009 0.0046
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.136 0.0747 0.7163
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.0052 0.0324
Echinococcus multilocularis 0.004 0.0011 0.0011
Leishmania major heat shock protein 83-1 0.0035 0.0009 0.0022
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0298 0.0155 0.0445
Toxoplasma gondii hypothetical protein 0.0089 0.0038 0.0508
Brugia malayi jmjC domain containing protein 0.0185 0.0092 0.0876
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.1398 0.0768 0.7367
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0298 0.0155 0.0155
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0298 0.0155 0.0874
Trichomonas vaginalis PIKK family atypical protein kinase 0.0788 0.0428 0.4101
Trypanosoma brucei heat shock protein, putative 0.0035 0.0009 0.0105
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0029 0.0005 0.003
Onchocerca volvulus 0.003 0.0006 0.0277
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0298 0.0155 0.1484
Trypanosoma cruzi cytochrome P450, putative 0.006 0.0022 0.0063
Loa Loa (eye worm) hypothetical protein 0.0044 0.0013 0.0083
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0012 0.0106
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0088 0.0038 0.05
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0037
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.1077 0.0589 0.7888
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.004 0.0011 0.0684
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0298 0.0155 0.0445
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.1592 0.0876 0.8403
Schistosoma mansoni hypothetical protein 0.0036 0.0009 0.0046
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0006 0.0208
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0044 0.0243
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0001 0.0001
Schistosoma mansoni microtubule-associated protein tau 0.2211 0.122 0.6896
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0062 0.4654
Loa Loa (eye worm) hypothetical protein 0.0777 0.0422 0.265
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0472 0.0252 0.3364
Brugia malayi latrophilin 2 splice variant baaae 0.0077 0.0032 0.0298
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0777 0.0422 0.0421
Leishmania major phosphatidylinositol kinase related protein, putative 0.031 0.0161 0.0441
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0012 0.0106
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.006 0.0022 0.1642
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.031 0.0161 0.0462
Echinococcus granulosus cytochrome P450 2K1 0.004 0.0011 0.0011
Entamoeba histolytica hypothetical protein 0.1569 0.0863 0.8283
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0298 0.0155 0.0155
Plasmodium vivax endoplasmin, putative 0.0035 0.0009 0.0313
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0028 0.0005 0.025
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0049 0.0016 0.0212
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0009 0.0055
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0472 0.0252 0.241
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0866 0.0472 0.6313
Schistosoma mansoni cpg binding protein 0.0031 0.0006 0.0033
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0472 0.0252 0.241
Loa Loa (eye worm) hypothetical protein 0.051 0.0273 0.1715
Leishmania major heat shock protein 83-1 0.0035 0.0009 0.0022
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.189 0.1042 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0046 0.0431
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0046 0.0045
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0257 0.0132 0.0132
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0062 0.4654
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0012 0.0032
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0089 0.0038 0.286
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0472 0.0252 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0044 0.0043
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0012 0.0106
Echinococcus granulosus histone acetyltransferase KAT2B 0.0289 0.015 0.0149
Loa Loa (eye worm) hypothetical protein 0.0125 0.0058 0.0367
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.004 0.0011 0.0684
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0112 0.0052 0.0488
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0009 0.0075
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1346 0.0739 0.9892
Trichomonas vaginalis conserved hypothetical protein 0.0478 0.0255 0.2445
Echinococcus multilocularis dnaJ subfamily B 0.0424 0.0225 0.0224
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0001 0.0023
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0472 0.0252 0.3386
Brugia malayi hypothetical protein 0.0022 0.0001 0.0005
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0169 0.0083 0.5202
Leishmania major hypothetical protein, conserved 0.6564 0.3645 1
Schistosoma mansoni lipoxygenase 0.0132 0.0063 0.035
Schistosoma mansoni protein phosphatase 2C 0.0049 0.0016 0.0089
Brugia malayi CXXC zinc finger family protein 0.003 0.0006 0.0046
Echinococcus granulosus endoplasmin 0.0028 0.0005 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.1338 0.0734 0.7043
Schistosoma mansoni hypothetical protein 0.0298 0.0155 0.0874
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0298 0.0155 0.1484
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.004 0.0011 0.0803
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0298 0.0155 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.1346 0.0739 0.7089
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0792 0.043 0.4127
Loa Loa (eye worm) hypothetical protein 0.0154 0.0075 0.0469
Brugia malayi hypothetical protein 0.003 0.0006 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.079 0.0429 0.4116
Loa Loa (eye worm) phosphatidylinositol kinase 0.0298 0.0155 0.0976
Brugia malayi Cytochrome P450 family protein 0.004 0.0011 0.0101
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0012 0.0106
Schistosoma mansoni jumonji domain containing protein 0.0049 0.0016 0.0089
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0027 0.0004 0.003
Leishmania major heat shock protein 83-1 0.0035 0.0009 0.0022
Echinococcus multilocularis expressed conserved protein 0.0096 0.0042 0.0041
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.004 0.0011 0.0803
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.007 0.0069
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0472 0.0252 0.0722
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.004 0.0011 0.0031
Plasmodium falciparum endoplasmin, putative 0.0022 0.0001 0.0011
Onchocerca volvulus 0.0104 0.0047 0.2961
Schistosoma mansoni hypothetical protein 0.0022 0.0001 0.0003
Brugia malayi CHE-14 protein 0.0044 0.0013 0.0121
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0859 0.0468 0.6302
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0024 0.0132
Plasmodium falciparum heat shock protein 90 0.0035 0.0009 0.0313
Plasmodium falciparum histone acetyltransferase GCN5 0.008 0.0034 0.1314
Giardia lamblia Hypothetical protein 0.0298 0.0155 0.2071
Leishmania major phosphatidylinositol 3-kinase, putative 0.0472 0.0252 0.0688
Schistosoma mansoni hypothetical protein 0.0042 0.0012 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.1351 0.0742 0.7117
Echinococcus multilocularis survival motor neuron protein 1 0.051 0.0273 0.0272
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.3196 0.1769 0.1769
Leishmania major heat shock protein 83-1 0.0035 0.0009 0.0022
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0012 0.0011
Echinococcus multilocularis GPCR, family 2 0.0036 0.0009 0.0008
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.004 0.0011 0.0803
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0012 0.0106
Echinococcus multilocularis JmjC domain containing protein 4 0.0049 0.0016 0.0016
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0012 0.0106
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0561 0.0301 0.0301
Trichomonas vaginalis endoplasmin, putative 0.0022 0.0001 0.0003
Trypanosoma cruzi cytochrome P450, putative 0.006 0.0022 0.0063
Schistosoma mansoni lipoxygenase 0.0092 0.004 0.0225
Giardia lamblia GTOR 0.136 0.0747 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0006 0.0208
Trypanosoma brucei glucosidase, putative 0.0041 0.0012 0.0148
Loa Loa (eye worm) phosphatidylinositol 3 0.1346 0.0739 0.4643
Echinococcus granulosus jumonji domain containing 1A 0.0049 0.0016 0.0016
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0131 0.0062 0.3964
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0009 0.0075
Brugia malayi acetyltransferase, GNAT family protein 0.0298 0.0155 0.148
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.0062 0.0346
Brugia malayi hypothetical protein 0.0022 0.0001 0.0005
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0792 0.043 0.4127
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0044 0.0043
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0029 0.0005 0.0004
Schistosoma mansoni hypothetical protein 0.0036 0.0009 0.0046
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0298 0.0155 0.0874
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0257 0.0132 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.004 0.0011 0.0684
Echinococcus granulosus JmjC domain containing protein 4 0.0049 0.0016 0.0016
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0001 0.0001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0792 0.043 0.4127
Toxoplasma gondii heat shock protein HSP90 0.0035 0.0009 0.0106
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0051 0.0017 0.0017
Echinococcus granulosus geminin 0.0175 0.0086 0.0086
Schistosoma mansoni loxhd1 0.0022 0.0001 0.0003
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0006 0.007
Echinococcus granulosus lysine specific demethylase 5A 0.0187 0.0093 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.1338 0.0734 0.7043
Echinococcus multilocularis cpg binding protein 0.0031 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.1353 0.0743 0.7126
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0792 0.043 0.4127
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.136 0.0747 0.7163
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0298 0.0155 0.1484
Leishmania major heat shock protein 83-1 0.0035 0.0009 0.0022
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0788 0.0428 0.1228
Loa Loa (eye worm) cytochrome P450 family protein 0.0126 0.0059 0.0373
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0472 0.0252 0.0251
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0049 0.0016 0.0046
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0838 0.0456 0.0455
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0185 0.0092 0.0577
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.004 0.0011 0.0803
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0257 0.0132 0.5
Entamoeba histolytica hypothetical protein 0.0298 0.0155 0.1484
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0777 0.0422 0.4042
Echinococcus granulosus serine protein kinase ATM 0.0788 0.0428 0.0427
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.004 0.0011 0.0684
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.136 0.0747 0.0746
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.136 0.0747 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.004 0.0011 0.0803
Leishmania major hypothetical protein, unknown function 0.0298 0.0155 0.0424
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.136 0.0747 0.2145
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.136 0.0747 0.2145
Loa Loa (eye worm) phosphatidylinositol 3 0.0298 0.0155 0.0976
Trichomonas vaginalis PIKK family atypical protein kinase 0.1344 0.0738 0.708
Leishmania major heat shock protein 83-1 0.0035 0.0009 0.0022
Entamoeba histolytica hypothetical protein 0.0788 0.0428 0.4101
Onchocerca volvulus 0.0298 0.0155 1
Trypanosoma brucei heat shock protein, putative 0.0035 0.0009 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0859 0.0468 0.4485
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.007 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.1345 0.0738 0.708
Schistosoma mansoni survival motor neuron protein 0.0104 0.0047 0.0261
Plasmodium vivax heat shock protein 86, putative 0.0035 0.0009 0.0313
Echinococcus granulosus microtubule associated protein 2 0.2211 0.122 0.122
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0006 0.0035
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.004 0.0011 0.0803
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0298 0.0155 0.2071
Loa Loa (eye worm) jmjC domain-containing protein 0.0187 0.0093 0.0584
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0046 0.0431
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0298 0.0155 0.0155
Schistosoma mansoni jumonji domain containing protein 0.0185 0.0092 0.0516
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.004 0.0011 0.0684
Schistosoma mansoni heat shock protein 0.0035 0.0009 0.0044
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1346 0.0739 0.2025
Echinococcus multilocularis heat shock protein 90 0.0028 0.0005 0.0004
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0013 0.0013
Plasmodium vivax hypothetical protein, conserved 0.0298 0.0155 0.6158
Brugia malayi jmjC domain containing protein 0.0049 0.0016 0.0151
Loa Loa (eye worm) heat shock protein 90 0.0035 0.0009 0.0054
Onchocerca volvulus 0.0298 0.0155 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0185 0.0092 0.0091
Mycobacterium tuberculosis Conserved hypothetical protein 0.0298 0.0155 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.136 0.0747 0.0746
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1376 0.0755 0.0755
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0472 0.0252 0.1419
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0028 0.0005 0.0011
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.004 0.0011 0.0803
Loa Loa (eye worm) hypothetical protein 0.0049 0.0016 0.0103
Schistosoma mansoni hypothetical protein 0.0036 0.0009 0.0046
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0494 0.0264 0.0758
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0472 0.0252 0.0251
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.004 0.0011 0.0684
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0472 0.0252 0.3386
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0009 0.0105
Toxoplasma gondii cytochrome p450 superfamily protein 0.004 0.0011 0.0143
Trypanosoma cruzi Heat shock protein 83, putative 0.0035 0.0009 0.0023
Trypanosoma brucei heat shock protein, putative 0.0035 0.0009 0.0105
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.004 0.0011 0.0803
Trypanosoma cruzi heat shock protein 85, putative 0.0028 0.0005 0.0012
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0089 0.0038 0.15
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0028 0.0005 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0013 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0799 0.0434 0.4162
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0049 0.0016 0.0212
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.004 0.0011 0.0803
Echinococcus multilocularis serine protein kinase ATM 0.0788 0.0428 0.0427
Schistosoma mansoni phosphatidylserine receptor 0.0049 0.0016 0.0089
Schistosoma mansoni jumonji/arid domain-containing protein 0.0187 0.0093 0.0521
Echinococcus granulosus RUN 0.0022 0.0001 0.0001
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0001 0.0008
Trypanosoma brucei heat shock protein, putative 0.0035 0.0009 0.0105
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.0052 0.0488
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0006 0.0208
Loa Loa (eye worm) hypothetical protein 0.0102 0.0046 0.0287
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1376 0.0755 0.4266
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0005 0.0037
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0298 0.0155 0.6158
Schistosoma mansoni hypothetical protein 0.004 0.0011 0.006
Trypanosoma cruzi cytochrome p450-like protein, putative 0.004 0.0011 0.0031
Schistosoma mansoni hypothetical protein 0.0104 0.0047 0.0261
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0298 0.0155 0.6158
Entamoeba histolytica protein kinase rad3, putative 0.0777 0.0422 0.4042
Giardia lamblia Heat shock protein HSP 90-alpha 0.0028 0.0005 0.0052
Loa Loa (eye worm) hypothetical protein 0.0257 0.0132 0.0832
Trichomonas vaginalis PIKK family atypical protein kinase 0.0777 0.0422 0.4042
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0298 0.0155 0.0445
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1338 0.0734 0.9832
Echinococcus multilocularis neuropeptide receptor A26 0.05 0.0268 0.0267
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0088 0.0038 0.0356
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0044 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0875 0.0476 0.4568
Echinococcus granulosus neuropeptide receptor A26 0.05 0.0268 0.0267
Loa Loa (eye worm) hypothetical protein 0.0606 0.0326 0.2052
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0472 0.0252 0.241
Loa Loa (eye worm) hypothetical protein 0.0077 0.0032 0.02
Echinococcus multilocularis Zinc finger, PHD finger 0.0472 0.0252 0.0251
Echinococcus granulosus heat shock protein 90 0.0035 0.0009 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.1338 0.0734 0.7043
Trichomonas vaginalis PIKK family atypical protein kinase 0.136 0.0747 0.7163
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.1306 0.0716 0.6874
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0298 0.0155 0.0871
Schistosoma mansoni hypothetical protein 0.0175 0.0086 0.0485
Echinococcus granulosus peptidase Clp S14 family 0.0169 0.0083 0.0082
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0027 0.0004 0.003
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.004 0.0011 0.0684
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0257 0.0132 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1353 0.0743 0.7126
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0029 0.0005 0.0004
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0169 0.0083 0.5322
Brugia malayi Probable ClpP-like protease 0.0257 0.0132 0.1264
Trichomonas vaginalis PIKK family atypical protein kinase 0.1351 0.0742 0.7117
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.004 0.0011 0.0684
Brugia malayi jmjC domain containing protein 0.0049 0.0016 0.0151
Schistosoma mansoni alpha glucosidase 0.0041 0.0012 0.0063
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0028 0.0005 0.0293
Trypanosoma cruzi hypothetical protein, conserved 0.6265 0.3479 1
Trypanosoma brucei cytochrome P450, putative 0.006 0.0022 0.029
Leishmania major heat shock protein 83-1 0.0035 0.0009 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.004 0.0011 0.0684
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0009 0.0075
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0169 0.0083 0.5322
Toxoplasma gondii target of rapamycin (TOR), putative 0.1351 0.0742 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0472 0.0252 1
Loa Loa (eye worm) phosphatidylinositol 3 0.136 0.0747 0.4694
Loa Loa (eye worm) hypothetical protein 0.0036 0.0009 0.0055
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0006 0.0015
Leishmania major hypothetical protein, conserved 0.003 0.0006 0.0014
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1376 0.0755 0.7246
Echinococcus granulosus GPCR family 2 0.0036 0.0009 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.1346 0.0739 0.7086
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0001 0.0001
Trypanosoma cruzi target of rapamycin kinase 3 0.1353 0.0743 0.2134
Loa Loa (eye worm) phosphatidylinositol 3 0.0494 0.0264 0.1661
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0777 0.0422 0.121
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1353 0.0743 0.2036
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0009 0.0023
Echinococcus multilocularis geminin 0.0175 0.0086 0.0086
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0012 0.0106
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0013 0.0013
Leishmania major cytochrome p450-like protein 0.004 0.0011 0.0029
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0561 0.0301 0.17
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0619 0.0334 0.4468
Toxoplasma gondii heat shock protein 90, putative 0.0035 0.0009 0.0106
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0005 0.0037
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0022 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.1351 0.0742 0.7117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0298 0.0155 0.1484
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0298 0.0155 0.0155
Schistosoma mansoni alpha-glucosidase 0.0159 0.0077 0.0434
Schistosoma mansoni cpg binding protein 0.0031 0.0006 0.0033
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1569 0.0863 0.8283
Leishmania major heat shock protein 83-1 0.0035 0.0009 0.0022
Brugia malayi Cytochrome P450 family protein 0.006 0.0022 0.0208
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0489 0.0261 0.075
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0964 0.0526 0.5042
Loa Loa (eye worm) hypothetical protein 0.1285 0.0705 0.4429
Trichomonas vaginalis PIKK family atypical protein kinase 0.0298 0.0155 0.1484
Echinococcus multilocularis neuropeptide s receptor 0.05 0.0268 0.0267
Leishmania major heat shock protein 83-1 0.0035 0.0009 0.0022
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0298 0.0155 0.0155
Schistosoma mansoni hypothetical protein 0.0175 0.0086 0.0485

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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