Detailed information for compound 1127213

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 317.411 | Formula: C13H26N4OPS
  • H donors: 2 H acceptors: 1 LogP: 2.22 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O]N1C(C)(C)CC(CC1(C)C)NP(=S)(N1CC1)N1CC1
  • InChi: 1S/C13H26N4OPS/c1-12(2)9-11(10-13(3,4)17(12)18)14-19(20,15-5-6-15)16-7-8-16/h11H,5-10H2,1-4H3,(H,14,20)
  • InChiKey: RFXOOOVHGUVGGW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tm gpcr rhodopsin 0.0086 0.0204 0.049
Entamoeba histolytica protein kinase, putative 0.0294 0.0845 1
Onchocerca volvulus 0.0086 0.0204 0.092
Brugia malayi PHD-finger family protein 0.0028 0.0024 0.0036
Brugia malayi P21-Rho-binding domain containing protein 0.0067 0.0143 0.0322
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0098 0.0239 0.0567
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.0683 0.1641
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0094 0.0203
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0086 0.0204 0.0204
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0086 0.0204 0.049
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0414 0.1913
Brugia malayi GnHR receptor homolog 0.0086 0.0204 0.0468
Brugia malayi Furin-like cysteine rich region family protein 0.1366 0.4162 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0086 0.0204 0.049
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.0094 0.0225
Loa Loa (eye worm) hypothetical protein 0.0101 0.0249 0.059
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0039 0.0071
Echinococcus granulosus histone lysine methyltransferase setb 0.0107 0.0267 0.0642
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0086 0.0204 0.0204
Schistosoma mansoni chromobox protein 0.0023 0.001 0.0023
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.0445 0.2062
Entamoeba histolytica hypothetical protein 0.0179 0.0492 0.5774
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.0281 0.0667
Echinococcus granulosus hypothetical protein 0.0086 0.0204 0.049
Loa Loa (eye worm) neuropeptide F receptor 0.0086 0.0204 0.0482
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0186 0.0833
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0007 0.0016
Schistosoma mansoni biogenic amine receptor 0.0086 0.0204 0.049
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0011 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0204 0.049
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0024 0.0059
Brugia malayi Steroid receptor seven-up type 2 0.0051 0.0094 0.0203
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.0281 0.3159
Loa Loa (eye worm) hypothetical protein 0.0148 0.0393 0.0938
Brugia malayi Cytochrome P450 family protein 0.0057 0.0113 0.0248
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0039 0.0352
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0012 0.0006
Schistosoma mansoni adenoreceptor 0.0086 0.0204 0.049
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0051 0.0094 0.0398
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0092 0.0988
Echinococcus multilocularis serotonin receptor 0.0086 0.0204 0.0204
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0011 0.0003
Brugia malayi photoreceptor-specific nuclear receptor 0.0051 0.0094 0.0203
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.0414 0.0994
Echinococcus granulosus biogenic amine 5HT receptor 0.0086 0.0204 0.049
Echinococcus multilocularis chromobox protein 1 0.0143 0.0381 0.0381
Mycobacterium tuberculosis Conserved hypothetical protein 0.0211 0.0588 0.1592
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0086 0.0204 0.0204
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.003 0.0066
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Entamoeba histolytica protein kinase, putative 0.0072 0.016 0.1802
Echinococcus multilocularis allatostatin A receptor 0.0086 0.0204 0.0204
Brugia malayi hypothetical protein 0.0086 0.0204 0.0468
Echinococcus multilocularis G-protein coupled receptor, putative 0.0086 0.0204 0.0204
Brugia malayi Bromodomain containing protein 0.0078 0.0179 0.0407
Entamoeba histolytica protein kinase domain containing protein 0.0294 0.0845 1
Brugia malayi hypothetical protein 0.0086 0.0204 0.0468
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0081 0.0187
Echinococcus granulosus allatostatin A receptor 0.0086 0.0204 0.049
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0067 0.0143 0.0344
Echinococcus granulosus Chromo domain 0.0023 0.001 0.0023
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0294 0.0845 1
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0211 0.0588 0.6929
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0128 0.0258
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0154 0.0414 0.0987
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0164 0.0445 0.107
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0086 0.0204 0.0482
Brugia malayi 6-phosphofructokinase 0.0111 0.0281 0.0653
Mycobacterium tuberculosis Probable oxidoreductase 0.0241 0.0684 0.1868
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0217
Schistosoma mansoni hypothetical protein 0.0179 0.0492 0.1182
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.0393 0.0924
Onchocerca volvulus 0.0063 0.0132 0.0579
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0092 0.0988
Brugia malayi RNA binding protein 0.0065 0.0137 0.0307
Loa Loa (eye worm) hypothetical protein 0.0107 0.0267 0.0635
Loa Loa (eye worm) G-protein coupled receptor 0.0086 0.0204 0.0482
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0294 0.0845 0.203
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0086 0.0204 0.049
Plasmodium falciparum thioredoxin reductase 0.0095 0.0231 0.2655
Loa Loa (eye worm) hypothetical protein 0.021 0.0585 0.1399
Treponema pallidum NADH oxidase 0.0033 0.0039 0.0164
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0039 0.0054
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0089 0.0212 0.2429
Onchocerca volvulus 0.0051 0.0094 0.0398
Treponema pallidum licC protein (licC) 0.0211 0.0588 1
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0087 0.021
Trichomonas vaginalis AGC family protein kinase 0.0294 0.0845 0.3952
Schistosoma mansoni amine GPCR 0.0086 0.0204 0.049
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0158 0.0425 0.1015
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0621 0.1858 0.4459
Brugia malayi hypothetical protein 0.0241 0.0683 0.1622
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0196 0.0542 0.1302
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0239 0.0574
Onchocerca volvulus Alhambra homolog 0.0028 0.0024 0.007
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0137 0.0329
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0086 0.0204 0.0468
Brugia malayi Probable ATP-dependent helicase DHX35 0.0371 0.1084 0.2587
Echinococcus multilocularis peregrin 0.0031 0.0032 0.0032
Onchocerca volvulus 0.0086 0.0204 0.092
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0217 0.0609 0.1022
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.003 0.0243
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0712 0.3323
Loa Loa (eye worm) hypothetical protein 0.0042 0.0068 0.0156
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0081 0.0195
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0051 0.0094 0.0094
Brugia malayi nuclear hormone receptor 0.0051 0.0094 0.0203
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0025 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0128 0.0128
Echinococcus granulosus Chromobox protein 3 0.0023 0.001 0.0023
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0087 0.021
Schistosoma mansoni hypothetical protein 0.0047 0.0081 0.0195
Entamoeba histolytica hypothetical protein 0.0067 0.0143 0.1598
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0039 0.0094
Schistosoma mansoni biogenic amine (5HT) receptor 0.0086 0.0204 0.049
Brugia malayi mbt repeat family protein 0.0049 0.0087 0.0188
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0098 0.0239 0.0553
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0039 0.0228
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0051 0.0094 0.0225
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.0228
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0089 0.0192
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0086 0.0204 0.0468
Trichomonas vaginalis set domain proteins, putative 0.0707 0.2123 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0158 0.0425 0.1002
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0087 0.0205 0.0923
Echinococcus granulosus orexin receptor type 2 0.0086 0.0204 0.049
Loa Loa (eye worm) CYP4Cod1 0.0027 0.002 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0204 0.049
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0204 0.0204
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.0228
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0437 0.1289 0.3097
Entamoeba histolytica protein kinase, putative 0.0164 0.0445 0.5215
Schistosoma mansoni hypothetical protein 0.03 0.0864 0.2076
Brugia malayi hypothetical protein 0.0086 0.0204 0.0468
Echinococcus multilocularis g protein coupled receptor 0.0086 0.0204 0.0204
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0039 0.0228
Echinococcus multilocularis mitogen activated protein kinase 0.0154 0.0414 0.0414
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0039 0.0228
Onchocerca volvulus 0.0137 0.0361 0.1663
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Echinococcus multilocularis mitogen activated protein kinase 14 0.0132 0.0346 0.0346
Schistosoma mansoni hypothetical protein 0.0086 0.0204 0.049
Schistosoma mansoni hypothetical protein 0.0086 0.0204 0.049
Loa Loa (eye worm) AUR protein kinase 0.0294 0.0845 0.2024
Echinococcus multilocularis 0.0423 0.1244 0.1244
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.1149 0.349 1
Echinococcus granulosus tar DNA binding protein 0.0065 0.0137 0.0329
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0081 0.0195
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0473 0.2192
Brugia malayi Bromodomain containing protein 0.0031 0.0032 0.0054
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0086 0.0204 0.049
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0154 0.0414 0.4773
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0241 0.0684 0.1255
Loa Loa (eye worm) helicase 0.0023 0.001 0.0015
Brugia malayi nuclear receptor NHR-88 0.0051 0.0094 0.0203
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0086 0.0204 0.0468
Echinococcus granulosus g protein coupled receptor 0.0086 0.0204 0.049
Schistosoma mansoni amine GPCR 0.0086 0.0204 0.049
Schistosoma mansoni protein kinase 0.0164 0.0445 0.107
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Onchocerca volvulus Tyrosine kinase homolog 0.0148 0.0395 0.1823
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0239 0.0574
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0218 0.0525
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0294 0.0845 0.0845
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0154 0.0414 0.4773
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0011 0.0003
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0051 0.0094 0.0225
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0204 0.0204
Echinococcus granulosus tachykinin peptides receptor 99D 0.0086 0.0204 0.049
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Echinococcus multilocularis dro:myosuppressin receptor 0.0086 0.0204 0.0204
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0128 0.0311
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0051 0.0094 0.0225
Echinococcus multilocularis GPCR, family 2 0.0047 0.0081 0.0081
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0241 0.0684 0.1868
Brugia malayi Heterochromatin protein 1 0.0143 0.0381 0.0894
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0087 0.0202
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.002 0.004
Echinococcus granulosus neuropeptide receptor A26 0.1023 0.31 0.7448
Echinococcus granulosus epidermal growth factor receptor 0.0734 0.2208 0.5306
Schistosoma mansoni neuropeptide receptor 0.0086 0.0204 0.049
Giardia lamblia Kinase, STE STE20 0.0164 0.0445 0.5128
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.001 0.0023
Echinococcus granulosus tm gpcr rhodopsin 0.0086 0.0204 0.049
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0294 0.0845 1
Plasmodium vivax glutathione reductase, putative 0.0095 0.0231 0.2655
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0217 0.0609 0.1651
Loa Loa (eye worm) neuropeptide F receptor 0.0086 0.0204 0.0482
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0086 0.0204 0.0204
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0007 0.0007
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0086 0.0204 0.0482
Brugia malayi ORL1-like opioid receptor 0.0086 0.0204 0.0468
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0218 0.0525
Trichomonas vaginalis AGC family protein kinase 0.0294 0.0845 0.3952
Loa Loa (eye worm) heterochromatin protein 1 0.0143 0.0381 0.0907
Schistosoma mansoni opsin-like receptor 0.0086 0.0204 0.049
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0204 0.049
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0251 0.0712 0.1692
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0011 0.0003
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0129 0.0129
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0051 0.0094 0.0225
Schistosoma mansoni tyrosine kinase 0.0437 0.1289 0.3097
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.0281 0.0701
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0087 0.0087
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0094 0.0094
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0164 0.0445 0.0445
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0204 0.0204
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0053 0.0053
Trypanosoma cruzi p21-activated kinase 3, putative 0.0098 0.0239 0.2654
Brugia malayi glutathione reductase 0.0095 0.0231 0.0534
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0108 0.026
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0086 0.0204 0.049
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.001 0.0023
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0217
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0132 0.0346 0.3948
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.0281 0.0751
Entamoeba histolytica protein kinase, putative 0.0294 0.0845 1
Loa Loa (eye worm) thioredoxin reductase 0.0095 0.0231 0.0548
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0108 0.0108
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0092 0.0872
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0024 0.0051
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0164 0.0445 0.107
Echinococcus granulosus geminin 0.1205 0.3663 0.8801
Brugia malayi follicle stimulating hormone receptor 0.0086 0.0204 0.0468
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0011 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0015
Brugia malayi G-protein coupled receptor 0.0086 0.0204 0.0468
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0094 0.0203
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0086 0.0204 0.0204
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0081 0.0173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0051 0.0094 0.0217
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0202 0.0486
Mycobacterium ulcerans hypothetical protein 0.0211 0.0588 0.1638
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0314 0.0746
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.1149 0.349 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0011 0.0026
Brugia malayi steroid hormone receptor 0.0051 0.0094 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0094 0.0203
Brugia malayi mbt repeat family protein 0.0049 0.0087 0.0188
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0051 0.0094 0.0225
Echinococcus granulosus mitogen activated protein kinase 0.0154 0.0414 0.0994
Trichomonas vaginalis AGC family protein kinase 0.0294 0.0845 0.3952
Echinococcus granulosus insulin receptor 0.0437 0.1289 0.3097
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Brugia malayi Protein kinase domain 0.0164 0.0445 0.1049
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0128 0.0308
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0051 0.0094 0.0217
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0108 0.026
Trypanosoma brucei aurora B kinase 0.0294 0.0845 1
Echinococcus multilocularis neuropeptide Y receptor 0.0086 0.0204 0.0204
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0137 0.0321
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0414 0.1913
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0051 0.0094 0.0203
Echinococcus granulosus ecdysone induced protein 78C 0.0051 0.0094 0.0225
Onchocerca volvulus 0.0086 0.0204 0.092
Loa Loa (eye worm) hypothetical protein 0.008 0.0186 0.0438
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.002 0.0025
Onchocerca volvulus 0.0049 0.0089 0.0377
Mycobacterium ulcerans hypothetical protein 0.0211 0.0588 0.1638
Loa Loa (eye worm) hypothetical protein 0.004 0.0061 0.0137
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0218 0.0218
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0241 0.0684 0.1868
Schistosoma mansoni neuropeptide receptor 0.0086 0.0204 0.049
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0445 0.2062
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0039 0.0139
Echinococcus multilocularis g protein coupled receptor 0.0086 0.0204 0.0204
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0223 0.0223
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0051 0.0094 0.0225
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Brugia malayi Muscleblind-like protein 0.015 0.0401 0.0943
Brugia malayi nuclear receptor NHR-67 0.0024 0.0011 0.0003
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0011 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0445 0.2062
Schistosoma mansoni hypothetical protein 0.0086 0.0204 0.049
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0227 0.064 0.1537
Loa Loa (eye worm) steroid hormone receptor 0.0051 0.0094 0.0217
Loa Loa (eye worm) G-protein coupled receptor 0.0086 0.0204 0.0482
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.001 0.001
Echinococcus multilocularis neuropeptide FF receptor 2 0.0086 0.0204 0.0204
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0011 0.0003
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0096
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0011 0.0026
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0113 0.0285 0.0685
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0086 0.0204 0.0204
Schistosoma mansoni protein kinase 0.0294 0.0845 0.203
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0086 0.0204 0.049
Schistosoma mansoni opsin-like receptor 0.0086 0.0204 0.049
Schistosoma mansoni bromodomain containing protein 0.0066 0.0141 0.0338
Brugia malayi Pre-SET motif family protein 0.0621 0.1858 0.4451
Brugia malayi MH2 domain containing protein 0.0122 0.0314 0.0732
Brugia malayi larval opioid receptor 0.0086 0.0204 0.0468
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0092 0.0988
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0154 0.0414 0.484
Entamoeba histolytica hypothetical protein 0.0179 0.0492 0.5774
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0086 0.0204 0.049
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.1149 0.349 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Brugia malayi WH1 domain containing protein 0.0067 0.0143 0.0322
Brugia malayi Cytochrome P450 family protein 0.0027 0.002 0.0026
Echinococcus granulosus peregrin 0.0031 0.0032 0.0077
Echinococcus multilocularis chromobox protein 2 0.0023 0.001 0.001
Echinococcus granulosus g protein coupled receptor 0.0086 0.0204 0.049
Loa Loa (eye worm) TK/INSR protein kinase 0.0437 0.1289 0.3091
Schistosoma mansoni biogenic amine receptor 0.0086 0.0204 0.049
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0043 0.0043
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0086 0.0204 0.0468
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0712 0.3323
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0018
Brugia malayi CHD4 protein 0.0025 0.0016 0.0015
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0067 0.0143 0.0336
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0086 0.0204 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0094 0.0203
Brugia malayi Dopamine receptor protein 1 0.0086 0.0204 0.0468
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0092 0.0988
Schistosoma mansoni opsin-like receptor 0.0086 0.0204 0.049
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0051 0.0094 0.0203
Echinococcus granulosus neuropeptide FF receptor 2 0.0086 0.0204 0.049
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0051 0.0094 0.0225
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0086 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0055 0.0108 0.0252
Echinococcus granulosus epidermal growth factor receptor 0.1366 0.4162 1
Trypanosoma cruzi aurora B kinase, putative 0.0294 0.0845 1
Brugia malayi hypothetical protein 0.0086 0.0204 0.0468
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0049 0.0118
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0217
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0018
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.0281 0.3159
Brugia malayi Tachykinin-like peptides receptor 99D 0.0086 0.0204 0.0468
Toxoplasma gondii thioredoxin reductase 0.0095 0.0231 0.2655
Onchocerca volvulus 0.0113 0.0285 0.1304
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0011 0.0011
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0108 0.0108
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0039 0.0094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0204 0.049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0218 0.0525
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Loa Loa (eye worm) glutathione reductase 0.0095 0.0231 0.0548
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.0281 0.0675
Brugia malayi nuclear hormone receptor 0.0024 0.0011 0.0003
Schistosoma mansoni protein kinase 0.0164 0.0445 0.107
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0414 0.1913
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0094 0.0225
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0011 0.0026
Brugia malayi hypothetical protein 0.0024 0.0011 0.0003
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0011 0.0026
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0051 0.0094 0.0094
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0137 0.0329
Echinococcus multilocularis neuropeptides capa receptor 0.0086 0.0204 0.0204
Loa Loa (eye worm) melatonin receptor type 1A 0.0086 0.0204 0.0482
Onchocerca volvulus 0.0086 0.0204 0.092
Loa Loa (eye worm) TYRA-2 protein 0.0086 0.0204 0.0482
Echinococcus multilocularis mitogen activated protein kinase 11 0.0132 0.0346 0.0346
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0039 0.0054
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0249 0.0576
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0059 0.0141
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0039 0.0352
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0137 0.0329
Schistosoma mansoni zinc finger protein 0.0024 0.0011 0.0026
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0051 0.0094 0.0225
Loa Loa (eye worm) hypothetical protein 0.015 0.0401 0.0956
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0164 0.0445 0.0445
Plasmodium vivax SET domain protein, putative 0.0089 0.0212 0.2429
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0294 0.0845 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0039
Trichomonas vaginalis STE family protein kinase 0.0072 0.016 0.0712
Schistosoma mansoni hypothetical protein 0.0028 0.0024 0.0059
Echinococcus multilocularis chromobox protein 1 0.0143 0.0381 0.0381
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0132 0.0346 0.3948
Entamoeba histolytica hypothetical protein 0.0067 0.0143 0.1598
Leishmania major trypanothione reductase 0.0095 0.0231 0.2561
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.0393 0.0924
Mycobacterium tuberculosis Probable reductase 0.0217 0.0609 0.1651
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0086 0.0204 0.049
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0128 0.1418
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0092 0.0872
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0086 0.0204 0.049
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0094 0.0225
Echinococcus multilocularis epidermal growth factor receptor 0.0734 0.2208 0.2208
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0096
Echinococcus granulosus fmrfamide receptor 0.0086 0.0204 0.049
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0107 0.0267 0.0642
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0039
Echinococcus multilocularis Chromo domain 0.0023 0.001 0.001
Schistosoma mansoni survival motor neuron protein 0.0049 0.0089 0.0214
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.001 0.0023
Plasmodium falciparum thioredoxin reductase 0.0033 0.0039 0.0352
Brugia malayi G-protein coupled receptor 0.0086 0.0204 0.0468
Schistosoma mansoni amine GPCR 0.0086 0.0204 0.049
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0015
Echinococcus granulosus serine:threonine protein kinase PAK 1 0.0092 0.0222 0.0533
Echinococcus granulosus chromobox protein 1 0.0143 0.0381 0.0915
Echinococcus granulosus neuropeptides capa receptor 0.0086 0.0204 0.049
Echinococcus multilocularis geminin 0.1205 0.3663 0.3663
Brugia malayi putative neuropeptide receptor NPR1 0.0086 0.0204 0.0468
Echinococcus multilocularis neuropeptide Y receptor 0.0086 0.0204 0.0204
Echinococcus granulosus mitogen activated protein kinase 11 0.0132 0.0346 0.0831
Schistosoma mansoni hypothetical protein 0.1205 0.3663 0.8801
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0086 0.0204 0.049
Trypanosoma brucei trypanothione reductase 0.0095 0.0231 0.2561
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Brugia malayi Serotonin receptor 0.0458 0.1354 0.3237
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0086 0.0204 0.0482
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0011 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0204 0.0204
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0204 0.0204
Schistosoma mansoni hypothetical protein 0.0049 0.0089 0.0214
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0218 0.0517
Schistosoma mansoni neuropeptide receptor 0.0086 0.0204 0.049
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0154 0.0414 0.4773
Echinococcus granulosus tm gpcr rhodopsin 0.0086 0.0204 0.049
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.0204 0.049
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.1149 0.349 1
Leishmania major protein kinase, putative 0.0294 0.0845 1
Schistosoma mansoni protein kinase 0.0072 0.016 0.0385
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.001 0.0023
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0086 0.0204 0.049
Schistosoma mansoni tyrosine kinase 0.0437 0.1289 0.3097
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0218 0.0525
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0018
Brugia malayi Pre-SET motif family protein 0.0089 0.0212 0.0489
Echinococcus multilocularis sex peptide receptor 0.0086 0.0204 0.0204
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.0281 0.4492
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0712 0.3323
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0018
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0217
Echinococcus granulosus neuropeptide receptor 0.0086 0.0204 0.049
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.0204 0.049
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Loa Loa (eye worm) hypothetical protein 0.0159 0.0428 0.1021
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.001 0.0023
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0051 0.0094 0.0094
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.002 0.004
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Brugia malayi G protein-coupled receptor F59B2.13 0.0086 0.0204 0.0468
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0107 0.0267 0.0642
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0018
Onchocerca volvulus Neuropeptide F receptor homolog 0.0086 0.0204 0.092
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0087 0.0087
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0039 0.0228
Onchocerca volvulus 0.0086 0.0204 0.092
Onchocerca volvulus 0.0086 0.0204 0.092
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0281 0.1283
Echinococcus multilocularis neuropeptides capa receptor 0.0086 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0074 0.0165 0.0388
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0251 0.0712 0.1704
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.002 0.0048
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0281 0.1283
Schistosoma mansoni coup transcription factor 0.0051 0.0094 0.0225
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Schistosoma mansoni tyrosine kinase 0.1366 0.4162 1
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0098 0.0239 0.0567
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0223 0.0537
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0096
Brugia malayi serine/threonine kinase 12 0.0294 0.0845 0.2012
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0039 0.0054
Loa Loa (eye worm) DEAH box polypeptide 35 0.0371 0.1084 0.2598
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0018
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0281 0.3246
Schistosoma mansoni nuclear receptor 0.0024 0.0011 0.0026
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0039 0.0352
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0039 0.0228
Loa Loa (eye worm) hypothetical protein 0.0374 0.1093 0.2619
Schistosoma mansoni tyrosine kinase 0.0726 0.2182 0.5242
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.0204 0.049
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0039 0.0352
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0051 0.0094 0.0203
Schistosoma mansoni tyrosine kinase 0.0726 0.2182 0.5242
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.0393 0.0938
Schistosoma mansoni biogenic amine receptor 0.0086 0.0204 0.049
Loa Loa (eye worm) hypothetical protein 0.0063 0.0132 0.0309
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0051 0.0094 0.0203
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0024 0.0178
Onchocerca volvulus 0.0086 0.0204 0.092
Schistosoma mansoni neuropeptide F-like receptor 0.0086 0.0204 0.049
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.0281 0.0675
Brugia malayi MAP kinase sur-1 0.0154 0.0414 0.0974
Giardia lamblia Aurora kinase 0.0294 0.0845 1
Schistosoma mansoni amine GPCR 0.0086 0.0204 0.049
Trichomonas vaginalis STE family protein kinase 0.0164 0.0445 0.2061
Trichomonas vaginalis chromobox protein, putative 0.0143 0.0381 0.1756
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0039 0.0228
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.003 0.0096
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0053 0.0127
Schistosoma mansoni tyrosine kinase 0.0734 0.2208 0.5306
Brugia malayi conserved hypotetical protein 0.0024 0.0011 0.0003
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0011 0.0018
Entamoeba histolytica protein kinase , putative 0.0294 0.0845 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0086 0.0204 0.049
Brugia malayi jmjC domain containing protein 0.0093 0.0223 0.0515
Onchocerca volvulus 0.0024 0.0011 0.0006
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.0113 0.0263
Schistosoma mansoni hypothetical protein 0.0047 0.0081 0.0195
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0011 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0094 0.0094
Brugia malayi Melatonin receptor type 1A 0.0086 0.0204 0.0468
Brugia malayi TAR-binding protein 0.0065 0.0137 0.0307
Loa Loa (eye worm) CHromoDomain protein family member 0.0025 0.0016 0.003
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.001 0.0023
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0154 0.0414 0.4773
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0137 0.0307
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0024 0.0059
Brugia malayi hypothetical protein 0.0032 0.0037 0.0066
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0024 0.0024
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0081 0.0081
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0445 0.2062
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0113 0.049
Onchocerca volvulus 0.0086 0.0204 0.092
Brugia malayi RE15519p 0.0086 0.0204 0.0468
Loa Loa (eye worm) hypothetical protein 0.0227 0.064 0.153
Brugia malayi neuropeptide F receptor 0.0086 0.0204 0.0468
Loa Loa (eye worm) AUR protein kinase 0.0294 0.0845 0.2024
Brugia malayi hypothetical protein 0.0024 0.0011 0.0003
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0154 0.0414 0.4773
Mycobacterium tuberculosis Conserved hypothetical protein 0.0211 0.0588 0.1592
Schistosoma mansoni chromobox protein 0.0143 0.0381 0.0915
Loa Loa (eye worm) DR-78 0.0024 0.0011 0.0018
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.0204 0.049
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.003 0.0243
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0204 0.049
Echinococcus granulosus neuropeptide Y receptor 0.0086 0.0204 0.049
Giardia lamblia Kinase, CMGC MAPK 0.0154 0.0414 0.4746
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Onchocerca volvulus Bile acid receptor homolog 0.0051 0.0094 0.0398
Brugia malayi ecdysteroid receptor 0.0051 0.0094 0.0203
Echinococcus multilocularis epidermal growth factor receptor 0.1366 0.4162 0.4162
Entamoeba histolytica protein kinase, putative 0.0072 0.016 0.1802
Brugia malayi serine/threonine-protein kinase 6 0.0294 0.0845 0.2012
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0437 0.1289 0.1289
Schistosoma mansoni amine GPCR 0.0086 0.0204 0.049
Echinococcus granulosus somatostatin receptor 0.0086 0.0204 0.049
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0196 0.0542 0.0542
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0086 0.0204 0.049
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0204 0.0204
Echinococcus granulosus neuropeptide receptor 0.0086 0.0204 0.049
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0128 0.0311
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0094 0.0225
Loa Loa (eye worm) hypothetical protein 0.0241 0.0683 0.1635
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0086 0.0204 0.0204
Echinococcus granulosus serotonin receptor 0.0086 0.0204 0.049
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0081 0.0173
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0217
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0281 0.3246
Schistosoma mansoni steroid hormone receptor ad4bp 0.0051 0.0094 0.0225
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.003 0.0243
Echinococcus granulosus neuropeptide Y receptor 0.0086 0.0204 0.049
Brugia malayi tailless protein 0.0024 0.0011 0.0003
Echinococcus multilocularis Chromobox protein 3 0.0023 0.001 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0011 0.0026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0094 0.0203
Echinococcus granulosus mitogen activated protein kinase 14 0.0132 0.0346 0.0831
Entamoeba histolytica p21-activated kinase 0.0164 0.0445 0.5215
Echinococcus multilocularis neuropeptide receptor A26 0.1023 0.31 0.31
Echinococcus multilocularis mitogen activated protein kinase 11 0.0132 0.0346 0.0346
Schistosoma mansoni neuropeptide receptor 0.0086 0.0204 0.049
Trichomonas vaginalis chromobox protein, putative 0.0143 0.0381 0.1756
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0096
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0217 0.0609 0.1651
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.002 0.002
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0132 0.0346 0.3948
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0086 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Schistosoma mansoni tyrosine kinase 0.0726 0.2182 0.5242
Onchocerca volvulus Protein ultraspiracle homolog 0.0051 0.0094 0.0398
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0011 0.0026
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0132 0.0346 0.3948
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0051 0.0094 0.0217
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0051 0.0094 0.0217
Schistosoma mansoni serine/threonine protein kinase 0.0294 0.0845 0.203
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0049 0.011
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0039
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.002 0.0039
Loa Loa (eye worm) MBCTL1 0.0055 0.0108 0.0252
Brugia malayi hypothetical protein 0.0374 0.1093 0.2608
Loa Loa (eye worm) hypothetical protein 0.0047 0.0081 0.0187
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Trichomonas vaginalis STE family protein kinase 0.0164 0.0445 0.2061
Loa Loa (eye worm) hypothetical protein 0.0374 0.1093 0.2619
Brugia malayi SET domain containing protein 0.0027 0.002 0.0024
Onchocerca volvulus Heterochromatin protein 1 homolog 0.008 0.0186 0.0833
Schistosoma mansoni histamine h1 receptor 0.0086 0.0204 0.049
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.002 0.0048
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0018
Echinococcus multilocularis fmrfamide receptor 0.0086 0.0204 0.0204
Brugia malayi jmjC domain containing protein 0.0036 0.0049 0.0095
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0204 0.0204
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0086 0.0204 0.0204
Echinococcus multilocularis muscleblind protein 0.015 0.0401 0.0401
Loa Loa (eye worm) phosphofructokinase 0.0111 0.0281 0.0667
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0049 0.0118
Schistosoma mansoni nuclear receptor 0.0024 0.0011 0.0026
Echinococcus granulosus peptide allatostatin:somatostatin 0.0086 0.0204 0.049
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0086 0.0204 0.049
Brugia malayi Dopamine receptor 0.0086 0.0204 0.0468
Onchocerca volvulus 0.0086 0.0204 0.092
Brugia malayi G protein-coupled receptor 0.0086 0.0204 0.0468
Schistosoma mansoni hypothetical protein 0.0021 0.0003 0.0008
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0081 0.0081
Echinococcus multilocularis mitogen activated protein kinase 3 0.0154 0.0414 0.0414
Toxoplasma gondii aurora kinase 0.0294 0.0845 1
Brugia malayi serine/threonine-protein kinase PAK 7 0.0072 0.016 0.0363
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0089 0.0212 0.0212
Schistosoma mansoni hypothetical protein 0.0047 0.0081 0.0195
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0072 0.016 0.0377
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0154 0.0414 0.4773
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0012 0.0006
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0086 0.0204 0.0482
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0445 0.2062
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0067 0.0143 0.0344
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0086 0.0204 0.0204
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0164 0.0445 0.0445
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0204 0.049
Echinococcus granulosus chromobox protein 1 0.0143 0.0381 0.0915
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.0228
Trypanosoma brucei protein kinase, putative 0.0154 0.0414 0.4773
Echinococcus granulosus alpha 1A adrenergic receptor 0.0086 0.0204 0.049
Schistosoma mansoni hypothetical protein 0.0023 0.0007 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0473 0.2192
Brugia malayi serine/threonine protein kinase 6 0.0294 0.0845 0.2012
Brugia malayi P38 map kinase family protein 2 0.0132 0.0346 0.081
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0011 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0051 0.0094 0.0203
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0011 0.0006
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0165 0.0395
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0018
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0217 0.0609 0.1651
Brugia malayi hypothetical protein 0.0179 0.0492 0.1162
Onchocerca volvulus 0.0086 0.0204 0.092
Brugia malayi Bromodomain containing protein 0.004 0.006 0.0122
Schistosoma mansoni hypothetical protein 0.0023 0.001 0.0023
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0108 0.0238
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.017 0.0408
Schistosoma mansoni neuropeptide F-like receptor 0.0086 0.0204 0.049
Echinococcus multilocularis PAK box P21 Rho binding 0.0067 0.0143 0.0143
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0086 0.0204 0.049
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0087 0.0369
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0039 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0086 0.0204 0.049
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.003 0.0243
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0154 0.0414 0.4773
Echinococcus granulosus g protein coupled receptor 0.0086 0.0204 0.049
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0734 0.2208 0.5306
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0227 0.064 0.1517
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0039 0.0228
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0712 0.3323
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0294 0.0845 1
Schistosoma mansoni chromobox protein 0.0143 0.0381 0.0915
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.0204 0.049
Brugia malayi hypothetical protein 0.0027 0.002 0.0025
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0217 0.0609 0.1651
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0445 0.2062
Trichomonas vaginalis STE family protein kinase 0.0164 0.0445 0.2061
Entamoeba histolytica protein kinase, putative 0.0072 0.016 0.1802
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0051 0.0094 0.0225
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0024 0.0178
Schistosoma mansoni hypothetical protein 0.0047 0.0081 0.0195
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0132 0.0346 0.0823
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0217
Echinococcus multilocularis neuropeptide s receptor 0.1023 0.31 0.31
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0281 0.1283
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.003 0.0243
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0108 0.026
Loa Loa (eye worm) TK/EGFR protein kinase 0.1366 0.4162 1
Plasmodium falciparum glutathione reductase 0.0033 0.0039 0.0352
Brugia malayi hypothetical protein 0.0086 0.0204 0.0468
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.0683 0.0683
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0086 0.0204 0.092
Schistosoma mansoni nuclear hormone receptor 0.0051 0.0094 0.0225
Loa Loa (eye worm) hypothetical protein 0.005 0.0092 0.0213
Schistosoma mansoni hypothetical protein 0.0086 0.0204 0.049
Onchocerca volvulus Huntingtin homolog 0.0374 0.1093 0.5124
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0039 0.0352
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0011 0.0003
Brugia malayi putative neuropeptide receptor 0.0086 0.0204 0.0468
Plasmodium falciparum glutathione reductase 0.0095 0.0231 0.2655
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0218 0.0503
Schistosoma mansoni hypothetical protein 0.0067 0.0143 0.0344
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0067 0.0143 0.0344
Loa Loa (eye worm) hypothetical protein 0.0049 0.0087 0.0202
Onchocerca volvulus 0.0049 0.0087 0.0369
Echinococcus granulosus neuropeptides capa receptor 0.0086 0.0204 0.049
Entamoeba histolytica hypothetical protein 0.0179 0.0492 0.5774
Brugia malayi Dopamine receptor protein 2 0.0086 0.0204 0.0468
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.0281 0.3159
Leishmania major hypothetical protein, conserved 0.005 0.0092 0.0872
Loa Loa (eye worm) hypothetical protein 0.0371 0.1084 0.2598
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0218 0.0218
Echinococcus multilocularis FTZ F1 alpha 0.0051 0.0094 0.0094
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0051 0.0094 0.0094
Echinococcus multilocularis g protein coupled receptor 0.0086 0.0204 0.0204
Trypanosoma cruzi trypanothione reductase, putative 0.0095 0.0231 0.2561
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0204 0.049
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0107 0.0267 0.0267
Brugia malayi nuclear receptor RXR 0.0024 0.0011 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0204 0.049
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0011 0.0026
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0128 0.0308
Echinococcus granulosus mitogen activated protein kinase 3 0.0154 0.0414 0.0994
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.003 0.0243
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0164 0.0445 0.107
Echinococcus granulosus g-protein coupled receptor 0.0086 0.0204 0.049
Echinococcus multilocularis G protein coupled receptor 139 0.0086 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0086 0.0204 0.049
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Echinococcus granulosus sex peptide receptor 0.0086 0.0204 0.049
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.001 0.001
Schistosoma mansoni chromobox protein 0.0023 0.001 0.0023
Schistosoma mansoni transcription factor LCR-F1 0.0179 0.0492 0.1182
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.002 0.0025
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0137 0.0321
Echinococcus multilocularis g-protein coupled receptor 0.0086 0.0204 0.0204
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0211 0.0588 0.1638
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0217
Echinococcus granulosus muscleblind protein 0.015 0.0401 0.0964
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0281 0.3246
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.0228
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0086 0.0204 0.049
Schistosoma mansoni myosin xvIII 0.0086 0.0204 0.049
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.0228
Brugia malayi PHD-finger family protein 0.0026 0.0017 0.0018
Onchocerca volvulus 0.0086 0.0204 0.092
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0086 0.0204 0.0204
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0179 0.0492 0.0492
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0095 0.0231 0.0558
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0087 0.021
Loa Loa (eye worm) AUR protein kinase 0.0294 0.0845 0.2024
Brugia malayi nuclear receptor NHR-88 0.0024 0.0011 0.0003
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0039 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.0428 0.1981
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0137 0.0329
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0039
Echinococcus granulosus biogenic amine 5HT receptor 0.0086 0.0204 0.049
Echinococcus granulosus G protein coupled receptor 139 0.0086 0.0204 0.049
Echinococcus multilocularis neuropeptide receptor 0.0086 0.0204 0.0204
Echinococcus multilocularis mitogen activated protein kinase 14 0.0132 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0051
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0086 0.0204 0.049
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0011 0.0026
Loa Loa (eye worm) hypothetical protein 0.0044 0.0074 0.0171
Schistosoma mansoni hypothetical protein 0.0067 0.0143 0.0344
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0218 0.0525
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.002 0.0048
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0011 0.0026
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Echinococcus granulosus FTZ F1 alpha 0.0051 0.0094 0.0225
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Echinococcus multilocularis neuropeptide receptor 0.0086 0.0204 0.0204
Echinococcus granulosus 7tm_1 domain containing protein 0.0086 0.0204 0.049
Brugia malayi neuropeptide F receptor 0.0086 0.0204 0.0468
Onchocerca volvulus 0.0086 0.0204 0.092
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0051 0.0094 0.0225
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0039 0.0139
Echinococcus multilocularis somatostatin receptor 0.0086 0.0204 0.0204
Trichomonas vaginalis STE family protein kinase 0.0164 0.0445 0.2061
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0086 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.015 0.0401 0.0956
Echinococcus granulosus chromobox protein 2 0.0023 0.001 0.0023
Schistosoma mansoni hypothetical protein 0.0101 0.0249 0.0598
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0098 0.0239 0.2654
Plasmodium falciparum serine/threonine protein kinase, putative 0.0294 0.0845 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0086 0.0204 0.049
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0039 0.0039
Echinococcus multilocularis serotonin receptor 0.0086 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Loa Loa (eye worm) RNA binding protein 0.0065 0.0137 0.0321
Loa Loa (eye worm) hypothetical protein 0.0048 0.0087 0.0201
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0039 0.0228
Brugia malayi AKH receptor 0.0086 0.0204 0.0468
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0314 0.0746
Entamoeba histolytica hypothetical protein 0.0179 0.0492 0.5774
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0186 0.0833
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0051 0.0094 0.0217
Echinococcus granulosus thioredoxin glutathione reductase 0.0095 0.0231 0.0556
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0712 0.3323
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0414 0.1913
Brugia malayi Thioredoxin reductase 0.0095 0.0231 0.0534
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0128 0.0311
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0128 0.1308
Echinococcus multilocularis muscleblind protein 1 0.015 0.0401 0.0401
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.0228
Echinococcus multilocularis orexin receptor type 2 0.0086 0.0204 0.0204
Echinococcus multilocularis thyroid hormone receptor alpha 0.0051 0.0094 0.0094
Brugia malayi hypothetical protein 0.0086 0.0204 0.0468
Brugia malayi hypothetical protein 0.0086 0.0204 0.0468
Toxoplasma gondii 6-phosphofructokinase 0.003 0.003 0.0243
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0011 0.0011
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0025 0.0016 0.0038
Schistosoma mansoni growth hormone secretagogue receptor 0.0086 0.0204 0.049
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0051 0.0094 0.0203
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0094 0.0203
Echinococcus multilocularis ecdysone induced protein 78C 0.0051 0.0094 0.0094
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0098 0.0239 0.1086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.0228
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.003 0.0243
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0025 0.0016 0.0016
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0086 0.0204 0.049
Brugia malayi 6-phosphofructokinase 0.0111 0.0281 0.0653
Schistosoma mansoni protein kinase 0.0067 0.0143 0.0344
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.0228
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0096
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0129 0.0311
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0049 0.0118
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0087 0.021
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0024 0.0178
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0011 0.0026
Brugia malayi hypothetical protein 0.0086 0.0204 0.0468
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.0281 0.0675
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.0281 0.0281
Brugia malayi chromobox protein homolog 3 0.008 0.0186 0.0424
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0051 0.0094 0.0217
Brugia malayi Protein kinase domain containing protein 0.0437 0.1289 0.3081
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0113 0.049
Onchocerca volvulus 0.0086 0.0204 0.092
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0039
Echinococcus granulosus neuropeptide s receptor 0.1023 0.31 0.7448
Brugia malayi nuclear receptor RXR 0.0027 0.002 0.0025
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Echinococcus granulosus 7TM GPCR rhodopsin 0.0086 0.0204 0.049
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0179 0.0492 0.1182
Onchocerca volvulus 0.0024 0.0011 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0445 0.2062
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.0204 0.049
Brugia malayi Serotonin receptor 0.0086 0.0204 0.0468
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0011 0.0018
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0092 0.0872
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0712 0.3323
Echinococcus granulosus dro:myosuppressin receptor 0.0086 0.0204 0.049
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0051 0.0094 0.0203
Schistosoma mansoni RAR-like nuclear receptor 0.0051 0.0094 0.0225
Brugia malayi hypothetical protein 0.0086 0.0204 0.0468
Mycobacterium tuberculosis Probable dehydrogenase 0.0217 0.0609 0.1651
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0087 0.021
Schistosoma mansoni hypothetical protein 0.1205 0.3663 0.8801
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Onchocerca volvulus Huntingtin homolog 0.0374 0.1093 0.5124
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0015
Brugia malayi hypothetical protein 0.0086 0.0204 0.0468
Schistosoma mansoni hypothetical protein 0.0067 0.0143 0.0344
Onchocerca volvulus 0.0086 0.0204 0.092
Brugia malayi hypothetical protein 0.0027 0.002 0.0025
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0128 0.0308
Onchocerca volvulus 0.0086 0.0204 0.092
Brugia malayi Cytochrome P450 family protein 0.0027 0.002 0.0026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0204 0.0204
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0011 0.0026
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.0204 0.049
Brugia malayi P21-Rho-binding domain containing protein 0.0067 0.0143 0.0322
Loa Loa (eye worm) hypothetical protein 0.0227 0.064 0.153
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0086 0.0204 0.0482
Brugia malayi sulfakinin receptor protein 0.0086 0.0204 0.0468
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.003 0.0096
Plasmodium vivax thioredoxin reductase, putative 0.0095 0.0231 0.2655
Echinococcus multilocularis insulin receptor 0.0437 0.1289 0.1289
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0204 0.049
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0281 0.1283
Echinococcus multilocularis PAK box P21 Rho binding 0.0072 0.016 0.016
Schistosoma mansoni tyrosine kinase 0.0734 0.2208 0.5306
Onchocerca volvulus 0.0086 0.0204 0.092
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0118 0.0275
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0445 0.2062
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0482
Echinococcus granulosus aurora kinase A 0.0294 0.0845 0.203
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0039 0.0177
Brugia malayi ecdysone receptor 0.0024 0.0011 0.0003
Onchocerca volvulus 0.0707 0.2123 1
Echinococcus granulosus GPCR family 2 0.0047 0.0081 0.0195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0051 0.0094 0.0217
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0067 0.0143 0.0143
Echinococcus granulosus PAK box P21 Rho binding 0.0067 0.0143 0.0344
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.0281 0.0667
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0094 0.0203
Schistosoma mansoni tyrosine kinase 0.0075 0.017 0.0408
Onchocerca volvulus 0.0023 0.001 0.0000000546
Brugia malayi hypothetical protein 0.005 0.0092 0.0199
Onchocerca volvulus 0.0086 0.0204 0.092
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0137 0.0329
Echinococcus multilocularis thioredoxin glutathione reductase 0.0095 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0217
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0015
Trichomonas vaginalis chromobox protein, putative 0.0087 0.0205 0.0923
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0018
Trichomonas vaginalis chromobox protein, putative 0.0087 0.0205 0.0923
Echinococcus multilocularis fmrfamide receptor 0.0086 0.0204 0.0204
Trichomonas vaginalis AGC family protein kinase 0.0294 0.0845 0.3952
Plasmodium falciparum phd finger protein, putative 0.0028 0.0024 0.0178
Brugia malayi phosphofructokinase 0.0111 0.0281 0.0653
Schistosoma mansoni retinoic acid receptor RXR 0.0051 0.0094 0.0225
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0039 0.0352
Echinococcus multilocularis aurora kinase A 0.0294 0.0845 0.0845
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0094 0.0225
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.0212 0.051

Activities

Activity type Activity value Assay description Source Reference
ILS (functional) = 34 % In vivo evaluation of percent increase in life span (ILS) against P388 lymphocytic leukemia in infected CD2F1 male mice and at 10 dose mg/kg ChEMBL. 6204051
ILS (functional) = 52 % In vivo evaluation of percent increase in life span (ILS) against P388 lymphocytic leukemia in infected CD2F1 male mice and at 20 dose mg/kg ChEMBL. 6204051
ILS (functional) = 96 % Antineoplastic activity against P388 leukemia in CD2F1 male mice and the percent increase in life span was measured on day 30. ChEMBL. 2431142
ILS (functional) = 96 % In vivo evaluation of percent increase in life span (ILS) against P388 lymphocytic leukemia in infected CD2F1 male mice and at 25 dose mg/kg ChEMBL. 6204051

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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