Detailed information for compound 1203037

Basic information

Technical information
  • TDR Targets ID: 1203037
  • Name: 4-[4-(4,6-dimethylpyrimidin-2-yl)piperazin-1- yl]-4-oxo-N-(5-propyl-1,3,4-thiadiazol-2-yl)b utanamide
  • MW: 417.528 | Formula: C19H27N7O2S
  • H donors: 1 H acceptors: 6 LogP: 1.44 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1nnc(s1)NC(=O)CCC(=O)N1CCN(CC1)c1nc(C)cc(n1)C
  • InChi: 1S/C19H27N7O2S/c1-4-5-16-23-24-19(29-16)22-15(27)6-7-17(28)25-8-10-26(11-9-25)18-20-13(2)12-14(3)21-18/h12H,4-11H2,1-3H3,(H,22,24,27)
  • InChiKey: BETYEEBQUBTSHB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[4-(4,6-dimethyl-2-pyrimidinyl)-1-piperazinyl]-4-oxo-N-(5-propyl-1,3,4-thiadiazol-2-yl)butanamide
  • 4-[4-(4,6-dimethylpyrimidin-2-yl)piperazin-1-yl]-4-keto-N-(5-propyl-1,3,4-thiadiazol-2-yl)butyramide
  • 4-[4-(4,6-Dimethyl-pyrimidin-2-yl)-piperazin-1-yl]-4-oxo-N-(5-propyl-[1,3,4]thiadiazol-2-yl)-butyramide
  • MLS000762963
  • SMR000438251
  • ZINC05164409
  • STOCK4S-43056

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0067 0.01
Entamoeba histolytica hypothetical protein 0.0113 0.0602 0.2077
Loa Loa (eye worm) hypothetical protein 0.0145 0.079 0.0936
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.038 0.0707
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0265 0.1499 0.1497
Brugia malayi Tyrosine-protein kinase abl-1 0.0167 0.0924 0.1095
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0333 0.1055
Plasmodium falciparum ataxin-2 like protein, putative 0.0258 0.1458 0.5355
Plasmodium falciparum glutathione reductase 0.0054 0.0254 0.0805
Onchocerca volvulus 0.0075 0.038 0.1055
Brugia malayi intermediate filament protein 0.0084 0.043 0.051
Echinococcus granulosus Nuclear hormone receptor HR96 0.0068 0.0338 0.065
Onchocerca volvulus Protein ultraspiracle homolog 0.0145 0.079 0.2486
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0333 0.1154
Brugia malayi beta-lactamase 0.0075 0.038 0.045
Schistosoma mansoni thyroid hormone receptor 0.0145 0.079 0.1375
Plasmodium vivax hypothetical protein, conserved 0.0075 0.038 0.1281
Brugia malayi Bromodomain containing protein 0.008 0.0408 0.0484
Echinococcus granulosus mothers against decapentaplegic 6 0.003 0.0113 0.0215
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0044 0.0077
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.026 0.0258
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0145 0.079 0.1526
Leishmania major GTP-binding protein, putative 0.0023 0.0067 0.0155
Schistosoma mansoni nuclear receptor 0.0068 0.0338 0.0587
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0044 0.0069
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0039 0.0036
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0015 0.0018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0145 0.079 0.0788
Echinococcus multilocularis RUN 0.0065 0.0317 0.0315
Brugia malayi hypothetical protein 0.0113 0.0602 0.0713
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0333 0.0331
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0465 0.2687 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0083 0.0159
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.038 0.1329
Brugia malayi beta-lactamase family protein 0.0075 0.038 0.045
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0144 0.0786 0.0932
Loa Loa (eye worm) MH2 domain-containing protein 0.0068 0.0336 0.0398
Schistosoma mansoni tar DNA-binding protein 0.0462 0.2665 0.4635
Echinococcus multilocularis thyroid hormone receptor alpha 0.0145 0.079 0.0788
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0145 0.079 0.0936
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0145 0.079 0.0788
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0044 0.0069
Trichomonas vaginalis glucosylceramidase, putative 0.0363 0.2083 0.4027
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0056 0.0142
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0455 0.2625 0.5079
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0482 0.2784 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.026 0.0258
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0158 0.087 0.1031
Brugia malayi Steroid receptor seven-up type 2 0.041 0.236 0.2796
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0032 0.0124 0.0323
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0465 0.2687 0.5203
Loa Loa (eye worm) MH1 domain-containing protein 0.003 0.0113 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0145 0.079 0.0936
Loa Loa (eye worm) nuclear receptor NHR-67 0.0068 0.0338 0.04
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0141 0.0462
Loa Loa (eye worm) histone methyltransferase 0.0022 0.0061 0.0072
Loa Loa (eye worm) hypothetical protein 0.0075 0.038 0.045
Trichomonas vaginalis glucosylceramidase, putative 0.0383 0.2199 0.4252
Onchocerca volvulus 0.0509 0.2946 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0465 0.2687 1
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0165 0.0163
Echinococcus multilocularis isocitrate dehydrogenase 0.0265 0.1499 0.1497
Plasmodium falciparum thioredoxin reductase 0.0054 0.0254 0.0805
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0305 0.1737 0.3353
Echinococcus multilocularis nuclear receptor nhr 48 0.0068 0.0338 0.0335
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0145 0.079 0.0788
Echinococcus granulosus Polycystic kidney disease protein 0.0065 0.0317 0.061
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0044 0.0054
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0056 0.0097
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0554 0.321 0.3803
Schistosoma mansoni Smad4 0.003 0.0113 0.0197
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0455 0.2625 0.2623
Brugia malayi N-terminal motif family protein 0.0188 0.1046 0.124
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0013 0.0012 0.001
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0044 0.0007
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.038 0.1254
Brugia malayi Probable isocitrate dehydrogenase 0.0032 0.0124 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0056 0.0142
Brugia malayi photoreceptor-specific nuclear receptor 0.0377 0.2162 0.2562
Echinococcus multilocularis mothers against decapentaplegic 2 0.003 0.0113 0.0111
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.038 0.066
Loa Loa (eye worm) hypothetical protein 0.0024 0.0077 0.0091
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0105 0.0553 0.0551
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0013 0.0012 0.001
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0081 0.0206
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0166 0.0318
Mycobacterium leprae Probable lipase LipE 0.0075 0.038 0.3749
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0012 0.0002 0.0003
Brugia malayi Latrophilin receptor protein 2 0.0455 0.2625 0.311
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0044 0.0082
Echinococcus granulosus dna polymerase eta 0.0021 0.0056 0.0103
Loa Loa (eye worm) hypothetical protein 0.0075 0.038 0.045
Loa Loa (eye worm) nuclear factor I 0.0038 0.0156 0.0185
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.038 0.0707
Trichomonas vaginalis esterase, putative 0.0075 0.038 0.0707
Toxoplasma gondii histone lysine methyltransferase SET1 0.0122 0.0658 0.2388
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0077 0.0191
Plasmodium falciparum importin beta, putative 0.0031 0.0115 0.0282
Echinococcus multilocularis lamin 0.0084 0.043 0.0428
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0141 0.0432
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0137 0.0745 0.8277
Brugia malayi glutathione reductase 0.0054 0.0254 0.03
Brugia malayi Augmenter of liver regeneration 0.0035 0.0141 0.0167
Schistosoma mansoni transcription factor LCR-F1 0.0113 0.0602 0.1047
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.038 0.1254
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0158 0.087 0.3195
Echinococcus multilocularis FTZ F1 alpha 0.0145 0.079 0.0788
Loa Loa (eye worm) hypothetical protein 0.0256 0.1451 0.1719
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.026 0.0308
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0105 0.0553 0.0551
Leishmania major trypanothione reductase 0.0054 0.0254 0.0855
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0265 0.1499 0.5513
Loa Loa (eye worm) hypothetical protein 0.009 0.0464 0.055
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0298 0.0573
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.041 0.236 0.2358
Echinococcus granulosus ecdysone induced protein 78C 0.0145 0.079 0.1526
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.038 0.1254
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.038 0.045
Brugia malayi Variant SH3 domain containing protein 0.0012 0.0002 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.321 0.6222
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0068 0.0338 0.065
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0081 0.0125
Entamoeba histolytica Ran family GTPase 0.0023 0.0067 0.0044
Brugia malayi isocitrate dehydrogenase 0.0265 0.1499 0.1776
Brugia malayi Isocitrate dehydrogenase 0.0265 0.1499 0.1776
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0077 0.0191
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0056 0.0076
Echinococcus granulosus neuropeptide receptor A26 0.0481 0.2779 0.5378
Schistosoma mansoni intermediate filament proteins 0.0084 0.043 0.0748
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0056 0.0142
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0137 0.0745 0.2584
Brugia malayi hypothetical protein 0.0065 0.0317 0.0376
Loa Loa (eye worm) hypothetical protein 0.0039 0.0166 0.0197
Entamoeba histolytica hypothetical protein 0.0025 0.0083 0.0103
Leishmania major hypothetical protein, conserved 0.0258 0.1458 0.5381
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0077 0.0081
Brugia malayi Pax transcription factor protein 2 0.0281 0.1597 0.1892
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.009 0.0464 0.055
Echinococcus multilocularis ecdysone induced protein 78C 0.0145 0.079 0.0788
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0141 0.045
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0123 0.0664 0.2288
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.038 0.1254
Schistosoma mansoni lozenge 0.006 0.0288 0.0501
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0048
Brugia malayi nuclear hormone receptor family member nhr-6 0.0068 0.0338 0.04
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0165 0.0315
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0158 0.087 0.3186
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0455 0.2625 0.311
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.087 0.1664
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0068 0.0336 0.0334
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0044 0.0014
Loa Loa (eye worm) hypothetical protein 0.0041 0.0173 0.0205
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0044 0.0007
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0328 0.1874 0.222
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0145 0.079 0.0936
Schistosoma mansoni growth factor receptor-bound protein 0.0012 0.0002 0.0004
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0032 0.0124 0.0215
Brugia malayi glutaminase DH11.1 0.0881 0.5148 0.6099
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0254 0.0251
Schistosoma mansoni tyrosine kinase 0.0013 0.0012 0.0021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0068 0.0338 0.065
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0056 0.0053
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0305 0.1737 0.1735
Brugia malayi steroid hormone receptor 0.0145 0.079 0.0936
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0141 0.045
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0077 0.0071
Echinococcus granulosus lipoxygenase domain containing protein 0.0065 0.0317 0.061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.026 0.0453
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0056 0.0111
Brugia malayi nuclear receptor RXR 0.0077 0.0386 0.0457
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0158 0.087 0.3173
Loa Loa (eye worm) hypothetical protein 0.0084 0.043 0.051
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0144 0.0786 0.2858
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0091 0.0089
Loa Loa (eye worm) hypothetical protein 0.0075 0.038 0.045
Brugia malayi ecdysone receptor 0.0068 0.0338 0.04
Onchocerca volvulus 0.0075 0.038 0.1055
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0316 0.0607
Schistosoma mansoni zinc finger protein 0.0016 0.0026 0.0045
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0044 0.0014
Loa Loa (eye worm) hypothetical protein 0.0068 0.0338 0.04
Trichomonas vaginalis glucosylceramidase, putative 0.0363 0.2083 0.4027
Onchocerca volvulus 0.0084 0.043 0.1231
Toxoplasma gondii melibiase subfamily protein 0.0105 0.0553 0.1997
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0199 0.0236
Schistosoma mansoni hypothetical protein 0.0983 0.5748 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0083 0.0159
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0305 0.1736 0.6426
Trypanosoma brucei trypanothione reductase 0.0054 0.0254 0.0884
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0044 0.01
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0044 0.0014
Brugia malayi nuclear receptor NHR-88 0.0068 0.0338 0.04
Schistosoma mansoni lamin 0.0084 0.043 0.0748
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0465 0.2687 0.5203
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0032 0.0124 0.03
Trypanosoma brucei protein kinase, putative 0.0158 0.087 0.3195
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0012 0.0002 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0145 0.079 0.0936
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0151 0.0288
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0145 0.079 0.0936
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0083 0.0231
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0037 0.0064
Schistosoma mansoni unc-13 (munc13) 0.0032 0.0124 0.0215
Loa Loa (eye worm) hypothetical protein 0.0068 0.0338 0.04
Loa Loa (eye worm) hypothetical protein 0.0075 0.038 0.045
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0333 0.1154
Mycobacterium tuberculosis Probable reductase 0.0123 0.0664 0.2288
Onchocerca volvulus 0.0478 0.276 0.9352
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0305 0.1736 0.6426
Onchocerca volvulus 0.0065 0.032 0.0848
Loa Loa (eye worm) hypothetical protein 0.0305 0.1737 0.2058
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0145 0.079 0.1375
Leishmania major DNA polymerase kappa, putative 0.0021 0.0056 0.0111
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0465 0.2687 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0465 0.2687 0.4674
Echinococcus granulosus Smad4 0.0068 0.0336 0.0646
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0039 0.0071
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0013 0.0012 0.001
Echinococcus multilocularis snurportin 1 0.0328 0.1874 0.1872
Schistosoma mansoni cpg binding protein 0.0062 0.0301 0.0523
Echinococcus granulosus mothers against decapentaplegic 5 0.0068 0.0336 0.0646
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0081 0.0125
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0044 0.0069
Brugia malayi ecdysteroid receptor 0.0145 0.079 0.0936
Schistosoma mansoni coup transcription factor 0.0145 0.079 0.1375
Schistosoma mansoni hypothetical protein 0.071 0.4132 0.7188
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0061 0.0059
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0067 0.0086
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0145 0.079 0.0788
Schistosoma mansoni nuclear hormone receptor 0.0068 0.0338 0.0587
Loa Loa (eye worm) pax transcription factor protein 2 0.0281 0.1597 0.1892
Trypanosoma brucei unspecified product 0.0021 0.0056 0.0142
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0141 0.0432
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0083 0.0174
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0465 0.2687 0.5203
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0041 0.0021
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0115 0.0365
Brugia malayi MH2 domain containing protein 0.0068 0.0336 0.0398
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.026 0.05
Loa Loa (eye worm) hypothetical protein 0.0031 0.0115 0.0136
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0083 0.0231
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0265 0.1499 0.5537
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0465 0.2687 0.5198
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0044 0.01
Loa Loa (eye worm) hypothetical protein 0.0072 0.0362 0.0428
Brugia malayi nuclear receptor NHR-67 0.0068 0.0338 0.04
Onchocerca volvulus Glucosylceramidase homolog 0.0363 0.2083 0.6991
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0091 0.0172
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0083 0.0145
Schistosoma mansoni hypothetical protein 0.0455 0.2625 0.4566
Mycobacterium tuberculosis Probable dehydrogenase 0.0123 0.0664 0.2288
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0056 0.0142
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0013 0.0012 0.001
Schistosoma mansoni zinc finger protein 0.0068 0.0338 0.0587
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0166 0.0197
Echinococcus granulosus snurportin 1 0.0328 0.1874 0.3624
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0056 0.0142
Loa Loa (eye worm) hypothetical protein 0.0077 0.0386 0.0457
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0465 0.2687 1
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0465 0.2687 1
Schistosoma mansoni Smad4 0.003 0.0113 0.0197
Brugia malayi hypothetical protein 0.0256 0.1451 0.1719
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0411 0.2364 0.2362
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0166 0.0528
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0083 0.0159
Schistosoma mansoni adapter molecule crk 0.0012 0.0002 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0145 0.079 0.0936
Toxoplasma gondii isocitrate dehydrogenase 0.0265 0.1499 0.5545
Loa Loa (eye worm) hypothetical protein 0.0039 0.0164 0.0194
Brugia malayi Bromodomain containing protein 0.0039 0.0165 0.0196
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0083 0.0082
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.032 0.0557
Brugia malayi hypothetical protein 0.0155 0.0848 0.1005
Schistosoma mansoni tar DNA-binding protein 0.0462 0.2665 0.4635
Schistosoma mansoni loxhd1 0.0065 0.0317 0.0551
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0037 0.0067
Onchocerca volvulus 0.0065 0.0317 0.0837
Mycobacterium tuberculosis Conserved protein 0.0075 0.038 0.1254
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0056 0.0111
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0084 0.043 0.051
Loa Loa (eye worm) transcription factor SMAD2 0.0999 0.5842 0.6921
Schistosoma mansoni importin beta-1 0.0031 0.0115 0.02
Entamoeba histolytica hypothetical protein 0.0113 0.0602 0.2077
Echinococcus multilocularis Polycystic kidney disease protein 0.0065 0.0317 0.0315
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0166 0.0422
Brugia malayi Importin beta-1 subunit 0.0031 0.0115 0.0136
Schistosoma mansoni smad 0.003 0.0113 0.0197
Trypanosoma brucei ISWI complex protein 0.0016 0.0026 0.0031
Loa Loa (eye worm) hypothetical protein 0.0256 0.1451 0.1719
Brugia malayi hypothetical protein 0.0166 0.0917 0.1087
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0465 0.2687 0.3183
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0044 0.0054
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0333 0.0579
Schistosoma mansoni retinoic acid receptor RXR 0.0145 0.079 0.1375
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0333 0.1182
Leishmania major DNA polymerase eta, putative 0.0021 0.0056 0.0111
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0068 0.0338 0.0335
Echinococcus multilocularis mothers against decapentaplegic 5 0.0068 0.0336 0.0334
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.038 0.1254
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0553 0.0963
Echinococcus granulosus tar DNA binding protein 0.0462 0.2665 0.5156
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.016 0.0883 0.1046
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0091 0.0158
Brugia malayi Nuclear hormone receptor E75 0.0068 0.0338 0.04
Mycobacterium ulcerans beta-lactamase 0.0075 0.038 0.0664
Echinococcus granulosus tyrosine protein kinase Fyn 0.0013 0.0012 0.0019
Echinococcus granulosus dnaJ subfamily B 0.0885 0.5166 1
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0056 0.0066
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0553 0.0963
Loa Loa (eye worm) hypothetical protein 0.0075 0.038 0.045
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0465 0.2687 0.4674
Loa Loa (eye worm) hypothetical protein 0.0068 0.0338 0.04
Loa Loa (eye worm) hypothetical protein 0.0039 0.0164 0.0194
Schistosoma mansoni ran 0.0023 0.0067 0.0117
Schistosoma mansoni nuclear hormone receptor 0.0068 0.0338 0.0587
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0305 0.1737 0.3353
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0077 0.0081
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0465 0.2687 0.2685
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0044 0.0069
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0166 0.0164
Loa Loa (eye worm) hypothetical protein 0.0145 0.079 0.0936
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0071 0.0084
Loa Loa (eye worm) hypothetical protein 0.1438 0.844 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.016 0.0883 0.1688
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.321 0.6222
Loa Loa (eye worm) hypothetical protein 0.0156 0.0855 0.1013
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0137 0.0745 0.2584
Brugia malayi nuclear receptor NHR-88 0.0145 0.079 0.0936
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0145 0.079 0.0936
Trichomonas vaginalis set domain proteins, putative 0.0509 0.2946 0.5709
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0465 0.2687 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0015 0.0021 0.0037
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0166 0.0462
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.038 0.1254
Brugia malayi RNA binding protein 0.0462 0.2665 0.3157
Echinococcus granulosus mitogen activated protein kinase 3 0.0158 0.087 0.1681
Echinococcus multilocularis lamin dm0 0.0084 0.043 0.0428
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0116 0.0617 0.1191
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0056 0.0142
Schistosoma mansoni smad1 5 8 and 0.0068 0.0336 0.0584
Schistosoma mansoni rab6-interacting 0.0065 0.0317 0.0551
Loa Loa (eye worm) hypothetical protein 0.0068 0.0338 0.04
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0056 0.0142
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0068 0.0338 0.0908
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0316 0.0314
Mycobacterium leprae conserved hypothetical protein 0.0075 0.038 0.3749
Schistosoma mansoni tar DNA-binding protein 0.0462 0.2665 0.4635
Brugia malayi Doublecortin family protein 0.0065 0.0317 0.0376
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0144 0.0786 0.2858
Loa Loa (eye worm) nuclear hormone receptor 0.0334 0.1907 0.226
Schistosoma mansoni nck2/grb4 0.0012 0.0002 0.0004
Schistosoma mansoni nuclear receptor 0.0068 0.0338 0.0587
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0077 0.0071
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0044 0.01
Brugia malayi hypothetical protein 0.0478 0.276 0.3271
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0032 0.0124 0.0578
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0462 0.2665 0.3157
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.032 0.0557
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.009 0.0464 0.0807
Onchocerca volvulus 0.0068 0.0338 0.0908
Brugia malayi Nuclear hormone receptor-like 1 0.0145 0.079 0.0936
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0044 0.0042
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0032 0.0124 0.0208
Loa Loa (eye worm) hepatopoietin HPO2 0.0035 0.0141 0.0167
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0116 0.0617 0.0615
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0141 0.0432
Brugia malayi Tyrosine-protein kinase abl-1 0.0249 0.1407 0.1667
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0044 0.0069
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0056 0.0142
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0013 0.0012 0.001
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0013 0.0012 0.001
Schistosoma mansoni hypothetical protein 0.0455 0.2625 0.4566
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0145 0.079 0.0936
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0173 0.0331
Loa Loa (eye worm) DR-78 0.0068 0.0338 0.04
Loa Loa (eye worm) hypothetical protein 0.0068 0.0338 0.04
Schistosoma mansoni lamin 0.0084 0.043 0.0748
Loa Loa (eye worm) hypothetical protein 0.0145 0.079 0.0936
Loa Loa (eye worm) hypothetical protein 0.0145 0.079 0.0936
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0032 0.0124 0.0146
Brugia malayi tailless protein 0.0068 0.0338 0.04
Schistosoma mansoni hypothetical protein 0.0328 0.1874 0.3259
Entamoeba histolytica hypothetical protein 0.0025 0.0081 0.0096
Loa Loa (eye worm) hypothetical protein 0.0042 0.018 0.0213
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0161 0.0884 1
Schistosoma mansoni ran 0.0023 0.0067 0.0117
Echinococcus granulosus GPCR family 2 0.0455 0.2625 0.5079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0145 0.079 0.0936
Trichomonas vaginalis glucosylceramidase, putative 0.0363 0.2083 0.4027
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0068 0.0336 0.0584
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0166 0.0528
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0077 0.0071
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.038 0.066
Echinococcus granulosus tyrosine protein kinase Fyn 0.0013 0.0012 0.0019
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.087 0.1664
Loa Loa (eye worm) glutathione reductase 0.0054 0.0254 0.03
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.032 0.1122
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0465 0.2687 1
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0254 0.0855
Brugia malayi MAP kinase sur-1 0.0158 0.087 0.1031
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0265 0.1499 0.1497
Plasmodium vivax SET domain protein, putative 0.0065 0.032 0.1056
Trichomonas vaginalis glucosylceramidase, putative 0.0363 0.2083 0.4027
Onchocerca volvulus Huntingtin homolog 0.0256 0.1451 0.4787
Mycobacterium ulcerans hypothetical protein 0.0075 0.038 0.0664
Trichomonas vaginalis glucosylceramidase, putative 0.0383 0.2199 0.4252
Schistosoma mansoni tyrosine kinase 0.0013 0.0012 0.0021
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0044 0.0069
Echinococcus multilocularis smad 0.0068 0.0336 0.0334
Schistosoma mansoni cpg binding protein 0.0068 0.0333 0.058
Echinococcus multilocularis microtubule associated protein 2 0.0712 0.4147 0.4146
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0077 0.0386 0.0672
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0077 0.0386 0.0457
Toxoplasma gondii ABC1 family protein 0.0075 0.038 0.1345
Trypanosoma cruzi PAB1-binding protein , putative 0.0258 0.1458 0.5381
Brugia malayi hypothetical protein 0.0258 0.1458 0.1727
Toxoplasma gondii thioredoxin reductase 0.0054 0.0254 0.0872
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0048
Leishmania major isocitrate dehydrogenase, putative 0.0032 0.0124 0.0367
Schistosoma mansoni hypothetical protein 0.0113 0.0602 0.1047
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0134
Brugia malayi beta-lactamase family protein 0.0075 0.038 0.045
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.038 0.0664
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0032 0.0124 0.0146
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0265 0.1499 0.5537
Schistosoma mansoni hypothetical protein 0.0455 0.2625 0.4566
Echinococcus granulosus cpg binding protein 0.0068 0.0333 0.0641
Schistosoma mansoni cpg binding protein 0.0068 0.0333 0.058
Echinococcus multilocularis tyrosine protein kinase Abl 0.0167 0.0924 0.0922
Schistosoma mansoni rab6-interacting 0.0065 0.0317 0.0551
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0056 0.0142
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0056 0.0103
Brugia malayi Probable isocitrate dehydrogenase 0.0032 0.0124 0.0146
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0553 0.0963
Schistosoma mansoni serine/threonine protein kinase 0.0158 0.087 0.1514
Onchocerca volvulus Bile acid receptor homolog 0.0145 0.079 0.2486
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0115 0.0353
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0145 0.079 0.1375
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0166 0.0292
Loa Loa (eye worm) hypothetical protein 0.0024 0.0077 0.0091
Brugia malayi TAR-binding protein 0.0462 0.2665 0.3157
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0083 0.0423 0.0736
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0068 0.0338 0.0335
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0265 0.1499 0.2899
Echinococcus granulosus microtubule associated protein 2 0.0712 0.4147 0.8026
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0044 0.0035
Brugia malayi nuclear hormone receptor family member odr-7 0.0068 0.0338 0.04
Plasmodium falciparum ataxin-2 like protein, putative 0.0258 0.1458 0.5355
Brugia malayi Smad1 0.0068 0.0336 0.0398
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0321 0.1834 0.2173
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0465 0.2687 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0145 0.079 0.0936
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0077 0.0071
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0254 0.0796
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.038 0.1254
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0067 0.0079
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0067 0.0079
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0013 0.0012 0.001
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0068 0.0338 0.0908
Echinococcus granulosus tyrosine protein kinase Src64B 0.0013 0.0012 0.0019
Brugia malayi Variant SH3 domain containing protein 0.0012 0.0002 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0145 0.079 0.0936
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0333 0.0395
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0333 0.0395
Brugia malayi Nuclear hormone receptor E75 0.0068 0.0338 0.04
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0044 0.0069
Loa Loa (eye worm) hypothetical protein 0.0065 0.0317 0.0376
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0265 0.1499 0.2608
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0013 0.0012 0.001
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0166 0.0318
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0145 0.079 0.1526
Plasmodium vivax glutathione reductase, putative 0.0054 0.0254 0.0805
Loa Loa (eye worm) hypothetical protein 0.0455 0.2625 0.311
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0265 0.1499 0.1497
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0465 0.2687 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0067 0.0155
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0077 0.0091
Echinococcus multilocularis mothers against decapentaplegic 6 0.003 0.0113 0.0111
Loa Loa (eye worm) TK/ABL protein kinase 0.0411 0.2364 0.28
Schistosoma mansoni hypothetical protein 0.0116 0.0617 0.1073
Loa Loa (eye worm) hypothetical protein 0.0038 0.0156 0.0185
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0067 0.0155
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0083 0.0071
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0123 0.0664 0.2288
Trichomonas vaginalis glucosylceramidase, putative 0.0363 0.2083 0.4027
Schistosoma mansoni hypothetical protein 0.0021 0.0058 0.0101
Plasmodium vivax multidomain scavenger receptor, putative 0.0065 0.0317 0.1044
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0145 0.079 0.0936
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0141 0.038
Loa Loa (eye worm) hypothetical protein 0.0145 0.079 0.0936
Schistosoma mansoni lipoxygenase 0.0271 0.1538 0.2675
Toxoplasma gondii LsmAD domain-containing protein 0.0258 0.1458 0.5389
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0077 0.0153
Echinococcus granulosus lipoxygenase domain containing protein 0.0065 0.0317 0.061
Plasmodium vivax ataxin-2 like protein, putative 0.0258 0.1458 0.5355
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0144 0.0786 0.2858
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0305 0.1736 0.6437
Loa Loa (eye worm) RNA binding protein 0.0462 0.2665 0.3157
Echinococcus granulosus importin subunit beta 1 0.0031 0.0115 0.0219
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0265 0.1499 0.5327
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.0347 0.0603
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0145 0.079 0.2486
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0056 0.0142
Schistosoma mansoni tyrosine kinase 0.0405 0.2329 0.4051
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0144 0.0786 0.2858
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0388 0.2228 0.431
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0113 0.0602 0.1161
Loa Loa (eye worm) hypothetical protein 0.0188 0.1046 0.124
Loa Loa (eye worm) hypothetical protein 0.0083 0.0423 0.0502
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0465 0.2687 0.5203
Loa Loa (eye worm) hypothetical protein 0.0478 0.276 0.3271
Schistosoma mansoni zinc finger protein 0.0024 0.0073 0.0127
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0077 0.0081
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0044 0.0087
Echinococcus multilocularis geminin 0.071 0.4132 0.4131
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0465 0.2687 1
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0465 0.2687 1
Loa Loa (eye worm) SRC-1 0.0013 0.0012 0.0014
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0144 0.0786 0.2858
Echinococcus granulosus lamin 0.0084 0.043 0.0829
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0044 0.0052
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0465 0.2687 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0056 0.0097
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0145 0.079 0.1526
Echinococcus multilocularis dnaJ subfamily B 0.0885 0.5166 0.5165
Onchocerca volvulus 0.009 0.0464 0.1349
Brugia malayi MH1 domain containing protein 0.0068 0.0336 0.0398
Loa Loa (eye worm) isocitrate dehydrogenase 0.0265 0.1499 0.1776
Brugia malayi MH2 domain containing protein 0.0068 0.0336 0.0398
Mycobacterium ulcerans lipase LipD 0.0075 0.038 0.0664
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0083 0.0423 0.0736
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0044 0.0007
Entamoeba histolytica tartrate dehydrogenase, putative 0.0032 0.0124 0.0259
Loa Loa (eye worm) hypothetical protein 0.0075 0.038 0.045
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0123 0.0664 0.2288
Loa Loa (eye worm) hypothetical protein 0.0068 0.0338 0.04
Onchocerca volvulus 0.0281 0.1597 0.5297
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0044 0.0069
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0044 0.0014
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0305 0.1737 0.2058
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0465 0.2687 1
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0465 0.2687 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0265 0.1499 0.5513
Loa Loa (eye worm) hypothetical protein 0.0065 0.0317 0.0376
Echinococcus granulosus smad 0.0068 0.0336 0.0646
Echinococcus multilocularis Protein lozenge 0.006 0.0288 0.0286
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0013 0.0012 0.0021
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0035 0.0141 0.0139
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0321 0.1834 0.2173
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0013 0.0012 0.001
Schistosoma mansoni hypothetical protein 0.0885 0.5166 0.8987
Loa Loa (eye worm) hypothetical protein 0.0068 0.0338 0.04
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0056 0.0076
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0077 0.0071
Brugia malayi Pre-SET motif family protein 0.0065 0.032 0.0379
Brugia malayi Sex muscle abnormal protein 5 0.0012 0.0002 0.0003
Loa Loa (eye worm) MH2 domain-containing protein 0.003 0.0113 0.0134
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0067 0.0065
Brugia malayi conserved hypotetical protein 0.0068 0.0338 0.04
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0056 0.0142
Echinococcus granulosus mixed lineage leukemia protein mll 0.0018 0.0039 0.0071
Loa Loa (eye worm) MH1 domain-containing protein 0.0068 0.0336 0.0398
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0333 0.0641
Brugia malayi PHD-finger family protein 0.0029 0.0105 0.0125
Brugia malayi MH2 domain containing protein 0.0999 0.5842 0.6921
Loa Loa (eye worm) hypothetical protein 0.007 0.0347 0.0411
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0465 0.2687 0.4674
Echinococcus granulosus tyrosine protein kinase Src42A 0.0013 0.0012 0.0019
Schistosoma mansoni RAR-like nuclear receptor 0.0145 0.079 0.1375
Brugia malayi Thioredoxin reductase 0.0054 0.0254 0.03
Loa Loa (eye worm) hypothetical protein 0.0077 0.0386 0.0457
Echinococcus granulosus nuclear receptor nhr 48 0.0068 0.0338 0.065
Mycobacterium tuberculosis Conserved protein 0.0075 0.038 0.1254
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0032 0.0124 0.0121
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0145 0.079 0.1526
Echinococcus granulosus zinc finger protein 0.0024 0.0073 0.0137
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0044 0.0069
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.007 0.0347 0.0644
Echinococcus granulosus Nuclear hormone receptor HR96 0.0068 0.0338 0.065
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0134 0.0727 0.1264
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.026 0.05
Echinococcus granulosus tyrosine protein kinase Lyn 0.0015 0.002 0.0035
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0058 0.0069
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0166 0.0528
Onchocerca volvulus 0.0084 0.043 0.1231
Brugia malayi RNA, U transporter 1 0.0087 0.045 0.0533
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0465 0.2687 0.4674
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0333 0.1154
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0145 0.079 0.0936
Schistosoma mansoni microtubule-associated protein tau 0.0712 0.4147 0.7214
Echinococcus multilocularis GPCR, family 2 0.0455 0.2625 0.2623
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0254 0.03
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0115 0.0365
Schistosoma mansoni hypothetical protein 0.071 0.4132 0.7188
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0265 0.1499 0.5537
Brugia malayi hypothetical protein 0.0077 0.0386 0.0457
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0465 0.2687 1
Echinococcus granulosus intermediate filament protein 0.0084 0.043 0.0829
Loa Loa (eye worm) hypothetical protein 0.0068 0.0338 0.04
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0145 0.079 0.0936
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0455 0.2625 0.5079
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0465 0.2687 1
Echinococcus granulosus lamin dm0 0.0084 0.043 0.0829
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.041 0.236 0.4566
Entamoeba histolytica hypothetical protein 0.0113 0.0602 0.2077
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0173 0.0171
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.038 0.045
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0067 0.0126
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0166 0.029
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.321 0.6222
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.0347 0.0603
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0032 0.0124 0.0146
Schistosoma mansoni Smad4 0.0068 0.0336 0.0584
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0077 0.0091
Echinococcus granulosus c src tyrosine kinase 0.0013 0.0012 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0048
Onchocerca volvulus 0.0075 0.038 0.1055
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0032 0.0124 0.0235
Plasmodium falciparum glutathione reductase 0.0019 0.0044 0.0014
Loa Loa (eye worm) MH2 domain-containing protein 0.0999 0.5842 0.6921
Loa Loa (eye worm) runx1 0.006 0.0288 0.0341
Onchocerca volvulus 0.0068 0.0338 0.0908
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1438 0.844 1
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.004 0.0048
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0158 0.087 0.3173
Schistosoma mansoni smad1 5 8 and 0.0068 0.0336 0.0584
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0081 0.0125
Trichomonas vaginalis glucosylceramidase, putative 0.0363 0.2083 0.4027
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0068 0.0338 0.0335
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.038 0.1356
Schistosoma mansoni tar DNA-binding protein 0.0462 0.2665 0.4635
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0265 0.1499 0.5551
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0077 0.0386 0.0672
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0158 0.087 0.3173
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0105 0.0553 0.1068
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0188 0.1046 0.3378
Loa Loa (eye worm) hypothetical protein 0.0068 0.0338 0.04
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0044 0.0069
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0305 0.1737 0.2058
Echinococcus multilocularis mitogen activated protein kinase 3 0.0158 0.087 0.0868
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0083 0.0244
Loa Loa (eye worm) hypothetical protein 0.0039 0.0166 0.0196
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0056 0.0142
Brugia malayi MH1 domain containing protein 0.0038 0.0156 0.0185
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0067 0.01
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0083 0.0082
Echinococcus multilocularis Smad4 0.0068 0.0336 0.0334
Brugia malayi Melibiase family protein 0.007 0.0347 0.0411
Onchocerca volvulus 0.0062 0.0301 0.078
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0145 0.079 0.1375
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.321 0.6222
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.026 0.0308
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0056 0.0142
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0056 0.0111
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0465 0.2687 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0077 0.0091
Brugia malayi Nuclear hormone receptor-like 1 0.0077 0.0386 0.0457
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0048
Brugia malayi MH1 domain containing protein 0.0068 0.0336 0.0398
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0166 0.0318
Brugia malayi MH1 domain containing protein 0.0038 0.0156 0.0185
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0305 0.1736 0.6426
Loa Loa (eye worm) hypothetical protein 0.0068 0.0338 0.04
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.038 0.0707
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0044 0.0014
Leishmania major importin beta-1 subunit, putative 0.0025 0.0081 0.0206
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0465 0.2687 0.5203
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0044 0.0069
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.321 0.6222
Echinococcus granulosus FTZ F1 alpha 0.0145 0.079 0.1526
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0166 0.0164
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0145 0.079 0.1526
Brugia malayi nuclear receptor RXR 0.0068 0.0338 0.04
Giardia lamblia Kinase, CMGC MAPK 0.0158 0.087 0.3126
Schistosoma mansoni smad1 5 8 and 0.0068 0.0336 0.0584
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0061 0.0114
Plasmodium falciparum LCCL domain-containing protein 0.0065 0.0317 0.1044
Echinococcus multilocularis c src tyrosine kinase 0.0013 0.0012 0.001
Mycobacterium ulcerans glutaminase 0.0881 0.5148 1
Brugia malayi mothers against decapentaplegic homolog 3 0.003 0.0113 0.0134
Schistosoma mansoni isocitrate dehydrogenase 0.0032 0.0124 0.0215
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0056 0.0066
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0077 0.0071
Echinococcus granulosus L aminoadipate semialdehyde 0.009 0.0464 0.0894
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0083 0.0423 0.0421
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0145 0.079 0.0936
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0166 0.0164
Entamoeba histolytica hypothetical protein 0.0113 0.0602 0.2077
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0077 0.0091
Schistosoma mansoni hypothetical protein 0.0065 0.0317 0.0551
Loa Loa (eye worm) latrophilin receptor protein 2 0.0455 0.2625 0.311
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0044 0.0087
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0388 0.2228 0.2226
Schistosoma mansoni tyrosine kinase 0.0013 0.0012 0.0021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0145 0.079 0.0788
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0465 0.2687 1
Trichomonas vaginalis ran, putative 0.0023 0.0067 0.0098
Loa Loa (eye worm) hypothetical protein 0.0068 0.0338 0.04
Loa Loa (eye worm) hypothetical protein 0.0068 0.0338 0.04
Loa Loa (eye worm) glutaminase 0.0881 0.5148 0.6099
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0077 0.0191
Loa Loa (eye worm) hypothetical protein 0.0145 0.079 0.0936
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0068 0.0338 0.04
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0056 0.0053
Schistosoma mansoni glutaminase 0.0881 0.5148 0.8955
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0455 0.2625 0.2623
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0158 0.087 0.3173
Loa Loa (eye worm) hypothetical protein 0.0258 0.1458 0.1727
Loa Loa (eye worm) intermediate filament protein 0.0084 0.043 0.051
Loa Loa (eye worm) hypothetical protein 0.0155 0.0848 0.1005
Trichomonas vaginalis glutaminase, putative 0.0881 0.5148 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.038 0.0707
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0115 0.0113
Schistosoma mansoni thyroid hormone receptor 0.0145 0.079 0.1375
Brugia malayi orphan nuclear receptor NR2E1 0.0068 0.0338 0.04
Mycobacterium tuberculosis Conserved protein 0.0075 0.038 0.1254
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0032 0.0124 0.0146
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0032 0.0124 0.0162
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0044 0.01
Echinococcus multilocularis dna polymerase eta 0.0021 0.0056 0.0053
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0465 0.2687 1
Leishmania major hypothetical protein, conserved 0.0035 0.0141 0.0432
Loa Loa (eye worm) hypothetical protein 0.0082 0.0421 0.0499
Brugia malayi Calcitonin receptor-like protein seb-1 0.1438 0.844 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0166 0.0558
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0465 0.2687 1
Leishmania major hypothetical protein, conserved 0.0075 0.038 0.1329
Schistosoma mansoni smad 0.0068 0.0336 0.0584
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0145 0.079 0.0936
Loa Loa (eye worm) hypothetical protein 0.0145 0.079 0.0936
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0465 0.2687 1
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.038 0.0664
Loa Loa (eye worm) hypothetical protein 0.0047 0.0213 0.0252
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0056 0.0029
Brugia malayi nuclear hormone receptor 0.0068 0.0338 0.04
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0056 0.0142
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0199 0.0236
Loa Loa (eye worm) hypothetical protein 0.0077 0.0386 0.0457
Echinococcus granulosus mothers against decapentaplegic 2 0.003 0.0113 0.0215
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.038 0.1329
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0166 0.029
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0013 0.0012 0.0019
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.038 0.0707
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.321 0.6222
Schistosoma mansoni polycystin 1-related 0.0065 0.0317 0.0551
Loa Loa (eye worm) hypothetical protein 0.0478 0.276 0.3271
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0113 0.0602 0.06
Schistosoma mansoni bromodomain containing protein 0.0068 0.0337 0.0587
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.087 0.1664
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0166 0.0292
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0068 0.0338 0.0587
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0013 0.0012 0.0019
Loa Loa (eye worm) hypothetical protein 0.0377 0.2162 0.2562
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0056 0.0111
Echinococcus multilocularis tar DNA binding protein 0.0462 0.2665 0.2663
Brugia malayi RNA recognition motif domain containing protein 0.0462 0.2665 0.3157
Brugia malayi Pre-SET motif family protein 0.0448 0.2582 0.3059
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0145 0.079 0.0936
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0145 0.079 0.0936
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0083 0.0145
Brugia malayi Nuclear hormone receptor-like 1 0.0077 0.0386 0.0457
Loa Loa (eye worm) hypothetical protein 0.0032 0.0124 0.0146
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0067 0.0173
Brugia malayi Intermediate filament tail domain containing protein 0.0084 0.043 0.051
Echinococcus multilocularis L aminoadipate semialdehyde 0.009 0.0464 0.0462
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.026 0.0453
Echinococcus granulosus tyrosine protein kinase Fyn 0.0013 0.0012 0.0019
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0044 0.0069
Loa Loa (eye worm) beta-lactamase 0.0075 0.038 0.045
Brugia malayi SRC-1 0.0013 0.0012 0.0014
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0077 0.0386 0.0743
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0158 0.087 0.3173
Brugia malayi hypothetical protein 0.0068 0.0338 0.04
Onchocerca volvulus 0.0065 0.0317 0.0837
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0039 0.0067
Brugia malayi nuclear hormone receptor 0.0145 0.079 0.0936
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0044 0.0069
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0037 0.0034
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0254 0.0487
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0161 0.0884 0.309
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0032 0.0124 0.0121
Echinococcus granulosus TGF beta signal transducer SmadC 0.0068 0.0336 0.0646
Brugia malayi hypothetical protein 0.0065 0.0317 0.0376
Echinococcus multilocularis lipoxygenase domain containing protein 0.0065 0.0317 0.0315
Schistosoma mansoni tyrosine kinase 0.0013 0.0012 0.0021
Mycobacterium ulcerans hypothetical protein 0.0024 0.0077 0.0071
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0068 0.0338 0.04
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0077 0.0071
Echinococcus multilocularis lipoxygenase domain containing protein 0.0065 0.0317 0.0315
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0151 0.0149
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0554 0.321 0.3803
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0141 0.038
Schistosoma mansoni DNA polymerase eta 0.0021 0.0056 0.0097
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0123 0.0664 0.2288
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0068 0.0338 0.0587
Loa Loa (eye worm) hypothetical protein 0.0983 0.5748 0.6811
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0066
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0056 0.0066
Echinococcus multilocularis mitogen activated protein kinase 0.0158 0.087 0.0868
Loa Loa (eye worm) steroid hormone receptor 0.0145 0.079 0.0936
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0083 0.0213
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.032 0.0318
Echinococcus multilocularis zinc finger protein 0.0024 0.0073 0.0071
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0145 0.079 0.1526
Onchocerca volvulus 0.0145 0.079 0.2486
Loa Loa (eye worm) hypothetical protein 0.0068 0.0338 0.04
Onchocerca volvulus Huntingtin homolog 0.0256 0.1451 0.4787
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0015 0.0018
Echinococcus multilocularis cpg binding protein 0.0068 0.0333 0.0331
Plasmodium falciparum thioredoxin reductase 0.0019 0.0044 0.0014
Plasmodium vivax importin-beta 2, putative 0.0031 0.0115 0.0282
Trichomonas vaginalis glucosylceramidase, putative 0.0363 0.2083 0.4027
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0158 0.087 0.3173
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0301 0.0356
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0305 0.1737 0.336
Brugia malayi hypothetical protein 0.0077 0.0386 0.0457
Onchocerca volvulus 0.0155 0.0848 0.2688
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0077 0.0153
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0077 0.0386 0.0384
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0056 0.0076
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0123 0.0664 0.7268
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0145 0.079 0.1375
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0013 0.0012 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0145 0.079 0.0936
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0056 0.0029
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0448 0.2582 0.3059
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0254 0.0805
Echinococcus granulosus geminin 0.071 0.4132 0.7997
Brugia malayi hypothetical protein 0.0068 0.0338 0.04
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0012 0.0002 0.0004
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0465 0.2687 0.2685
Echinococcus granulosus histone lysine methyltransferase setb 0.0083 0.0423 0.0816
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0018 0.0039 0.0036
Loa Loa (eye worm) doublecortin family protein 0.0065 0.0317 0.0376
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0166 0.0292
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.038 0.0731
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0067 0.0186
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1438 0.844 1
Echinococcus granulosus RUN 0.0065 0.0317 0.061
Loa Loa (eye worm) Smad1 0.0068 0.0336 0.0398
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0465 0.2687 0.5181
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0056 0.0111
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0032 0.0124 0.0235
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.038 0.0377
Trypanosoma cruzi PAB1-binding protein , putative 0.0258 0.1458 0.5381
Echinococcus multilocularis neuropeptide receptor A26 0.0481 0.2779 0.2778
Schistosoma mansoni hypothetical protein 0.0455 0.2625 0.4566
Loa Loa (eye worm) hypothetical protein 0.0077 0.0386 0.0457
Loa Loa (eye worm) hypothetical protein 0.0342 0.1956 0.2317
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0553 0.0963
Schistosoma mansoni lipoxygenase 0.0388 0.2228 0.3876
Onchocerca volvulus Mothers against decapentaplegic homolog 0.003 0.0113 0.0127
Brugia malayi CXXC zinc finger family protein 0.0062 0.0301 0.0356
Echinococcus granulosus mitogen activated protein kinase 0.0158 0.087 0.1681
Schistosoma mansoni steroid hormone receptor ad4bp 0.0145 0.079 0.1375
Echinococcus granulosus neuropeptide s receptor 0.0481 0.2779 0.5378
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0145 0.079 0.1375
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0056 0.0111
Trypanosoma brucei PAB1-binding protein , putative 0.0258 0.1458 0.5395
Schistosoma mansoni nuclear receptor nhr-48 0.0068 0.0338 0.0587
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0145 0.079 0.1375
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0465 0.2687 0.5198
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0037 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.026 0.0453
Toxoplasma gondii isocitrate dehydrogenase 0.0265 0.1499 0.5545
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0068 0.0338 0.0335
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0013 0.0012 0.001
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0035 0.0141 0.0269
Loa Loa (eye worm) TAR-binding protein 0.0462 0.2665 0.3157
Schistosoma mansoni tar DNA-binding protein 0.0462 0.2665 0.4635
Loa Loa (eye worm) glutaminase 2 0.0881 0.5148 0.6099
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0048
Brugia malayi latrophilin 2 splice variant baaae 0.0983 0.5748 0.6811
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0305 0.1736 0.6401
Mycobacterium tuberculosis Probable oxidoreductase 0.0137 0.0745 0.2584
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0056 0.0076
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0465 0.2687 1
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.087 0.1664
Brugia malayi MH2 domain containing protein 0.003 0.0113 0.0134
Schistosoma mansoni nuclear hormone receptor 0.0145 0.079 0.1375
Echinococcus granulosus dna polymerase kappa 0.0021 0.0056 0.0103
Echinococcus multilocularis neuropeptide s receptor 0.0481 0.2779 0.2778
Giardia lamblia DINP protein human, muc B family 0.0021 0.0056 0.0042
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0465 0.2687 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0411 0.2364 0.4573
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0068 0.0338 0.0335
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0265 0.1499 0.1497
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0265 0.1499 0.5551
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0145 0.079 0.0936
Schistosoma mansoni hypothetical protein 0.0016 0.0026 0.0045
Echinococcus multilocularis musashi 0.0084 0.043 0.0428
Schistosoma mansoni growth factor receptor-bound protein 0.0012 0.0002 0.0004
Echinococcus granulosus thyroid hormone receptor alpha 0.0068 0.0338 0.065

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.3115 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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