Detailed information for compound 1276791

Basic information

Technical information
  • TDR Targets ID: 1276791
  • Name: 4-(2-morpholin-4-yl-2-oxoethyl)morpholine-3,5 -dione
  • MW: 242.229 | Formula: C10H14N2O5
  • H donors: 0 H acceptors: 3 LogP: -1.65 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCOCC1)CN1C(=O)COCC1=O
  • InChi: 1S/C10H14N2O5/c13-8(11-1-3-16-4-2-11)5-12-9(14)6-17-7-10(12)15/h1-7H2
  • InChiKey: JFOGSCIZRLSHMZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(2-morpholino-2-oxo-ethyl)morpholine-3,5-dione
  • 4-(2-morpholino-2-oxoethyl)morpholine-3,5-dione
  • 4-(2-keto-2-morpholino-ethyl)morpholine-3,5-quinone
  • 4-(2-morpholin-4-yl-2-oxo-ethyl)morpholine-3,5-dione
  • MLS000105831
  • SMR000102807
  • ZINC01230311
  • Oprea1_450814

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2324 1
Trypanosoma cruzi cysteine peptidase, putative 0.0597 0.2324 0.4687
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0138 0.0496 0.211
Loa Loa (eye worm) hypothetical protein 0.0286 0.1081 0.2178
Loa Loa (eye worm) hypothetical protein 0.0138 0.0496 0.0995
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0028 0.0051
Schistosoma mansoni coup transcription factor 0.0021 0.0028 0.0045
Echinococcus multilocularis dna polymerase eta 0.002 0.0025 0.0023
Schistosoma mansoni ap endonuclease 0.0058 0.0176 0.0306
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0018 0.0042
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0232 0.0463
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0411 0.1583 0.6799
Loa Loa (eye worm) hypothetical protein 0.0138 0.0496 0.0995
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Giardia lamblia Cysteine protease 0.0138 0.0496 0.2571
Onchocerca volvulus 0.0101 0.0346 0.1458
Entamoeba histolytica hypothetical protein 0.0025 0.0045 0.0156
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0046 0.0196
Plasmodium falciparum importin beta, putative 0.0031 0.0068 0.0267
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0036 0.0092
Leishmania major acetyl-CoA synthetase, putative 0.005 0.0143 0.0603
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0018 0.0068
Entamoeba histolytica cysteine protease, putative 0.0325 0.1237 0.5305
Trichomonas vaginalis ran, putative 0.0023 0.0036 0.0116
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0074 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2324 1
Brugia malayi jmjC domain containing protein 0.0061 0.0186 0.0369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2324 1
Brugia malayi Cytochrome P450 family protein 0.0024 0.0039 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0138 0.0496 0.2103
Echinococcus multilocularis dna polymerase kappa 0.002 0.0025 0.0023
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0018 0.0068
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0047
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0021 0.0028 0.0052
Echinococcus multilocularis cathepsin L 0.0325 0.1237 0.1234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.0496 0.2103
Onchocerca volvulus 0.005 0.0143 0.0579
Entamoeba histolytica cysteine protease, putative 0.0325 0.1237 0.5305
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0156 0.0564 1
Leishmania major DNA polymerase kappa, putative 0.002 0.0025 0.0097
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0138 0.0496 0.211
Schistosoma mansoni lipoxygenase 0.0086 0.0286 0.0502
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0028 0.0051
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0007 0.0004
Loa Loa (eye worm) glutaminase 2 0.0274 0.1036 0.2086
Schistosoma mansoni alpha-glucosidase 0.0169 0.0618 0.109
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0018 0.0042
Brugia malayi jmjC domain containing protein 0.0016 0.0007 0.0008
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0025 0.0046
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0018 0.0068
Entamoeba histolytica pyruvate kinase, putative 0.0049 0.0139 0.0561
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0051
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0176 0.0756
Trypanosoma cruzi cysteine peptidase, putative 0.0597 0.2324 0.4687
Trichomonas vaginalis set domain proteins, putative 0.0287 0.1086 0.4653
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Onchocerca volvulus 0.0021 0.0026 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2324 1
Onchocerca volvulus 0.0114 0.0397 0.1678
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0025 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.0039 0.0352
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0597 0.2324 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0028 0.0025
Entamoeba histolytica cysteine proteinase, putative 0.0325 0.1237 0.5305
Plasmodium falciparum serine repeat antigen 5 0.0138 0.0496 0.211
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0232 0.2218
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0025 0.0046
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0143 0.0786
Loa Loa (eye worm) hypothetical protein 0.0186 0.0685 0.1378
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2324 1
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0721 0.3077
Schistosoma mansoni cpg binding protein 0.003 0.0062 0.0105
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0028 0.0025
Entamoeba histolytica cysteine protease, putative 0.0138 0.0496 0.2103
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0007 0.0008
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0728 0.0725
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0094 0.037
Onchocerca volvulus Pyruvate kinase homolog 0.007 0.0223 0.0926
Loa Loa (eye worm) pyruvate kinase 0.007 0.0223 0.0445
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0138 0.0496 0.0873
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0025 0.0109
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0026 0.0041
Echinococcus granulosus dna polymerase kappa 0.002 0.0025 0.004
Loa Loa (eye worm) hypothetical protein 0.0597 0.2324 0.4687
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0421 0.0844
Brugia malayi MH2 domain containing protein 0.012 0.0421 0.0844
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0025 0.0127
Plasmodium falciparum serine repeat antigen 7 0.0138 0.0496 0.211
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0145 0.0252
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0051
Schistosoma mansoni glutaminase 0.0274 0.1036 0.1829
Entamoeba histolytica cysteine protease, putative 0.0325 0.1237 0.5305
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0127 0.045 0.2511
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.2324 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.009 0.0087
Brugia malayi Papain family cysteine protease containing protein 0.0325 0.1237 0.2492
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0025 0.0046
Trichomonas vaginalis pyruvate kinase, putative 0.007 0.0223 0.0926
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0154 0.0268
Echinococcus granulosus dnaJ subfamily B 0.0423 0.1628 0.2878
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0156 0.0564 0.2417
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Trypanosoma brucei pyruvate kinase 1, putative 0.007 0.0223 0.096
Brugia malayi Cathepsin L-like precursor 0.0597 0.2324 0.4687
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0226 0.045
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0721 0.3077
Loa Loa (eye worm) hypothetical protein 0.0186 0.0685 0.1378
Loa Loa (eye worm) hypothetical protein 0.0778 0.3043 0.614
Loa Loa (eye worm) hypothetical protein 0.0072 0.0232 0.0463
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0028 0.0051
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0094 0.0092
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0054 0.0157 0.0651
Echinococcus granulosus cathepsin L 0.0325 0.1237 0.2185
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0176 0.035
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0028 0.0084
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0013 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2324 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0025 0.0109
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0156 0.0564 1
Toxoplasma gondii aldehyde dehydrogenase 0.0125 0.0441 0.1889
Brugia malayi cathepsin B-like cysteine proteinase 0.1258 0.4955 1
Trichomonas vaginalis esterase, putative 0.0072 0.0232 0.0964
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0138 0.0496 0.2103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2324 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.2324 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0325 0.1237 0.2185
Brugia malayi Cathepsin L-like precursor 0.0597 0.2324 0.4687
Leishmania major cathepsin L-like protease 0.0597 0.2324 1
Trichomonas vaginalis glutaminase, putative 0.0274 0.1036 0.4435
Schistosoma mansoni polycystin 1-related 0.0021 0.0026 0.0041
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0036 0.0141
Echinococcus granulosus snurportin 1 0.0334 0.1273 0.2249
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0232 0.0964
Brugia malayi Cathepsin L-like precursor 0.0597 0.2324 0.4687
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0028 0.0051
Loa Loa (eye worm) glutaminase 0.0274 0.1036 0.2086
Schistosoma mansoni cathepsin F (C01 family) 0.0597 0.2324 0.411
Brugia malayi pyruvate kinase, muscle isozyme 0.0015 0.0003 0.000005198
Brugia malayi Papain family cysteine protease containing protein 0.0138 0.0496 0.0995
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0154 0.0305
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0508 0.0894
Trypanosoma cruzi cruzipain precursor, putative 0.0186 0.0685 0.1378
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.005 0.0143 0.2264
Schistosoma mansoni hypothetical protein 0.0423 0.1628 0.2878
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0232 0.0406
Schistosoma mansoni survival motor neuron protein 0.0058 0.0176 0.0307
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0094 0.0162
Loa Loa (eye worm) hypothetical protein 0.0072 0.0232 0.0463
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0007 0.0017
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0094 0.0185
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0154 0.0268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.2324 1
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0441 0.0776
Onchocerca volvulus 0.0037 0.009 0.0352
Leishmania major 4-coumarate:coa ligase-like protein 0.017 0.0621 0.2663
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0334 0.1273 0.2565
Schistosoma mansoni pyruvate kinase 0.0036 0.0087 0.015
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0232 0.0229
Mycobacterium ulcerans fatty-acid-CoA ligase 0.017 0.0621 0.5986
Loa Loa (eye worm) pyruvate kinase 0.007 0.0223 0.0445
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2324 1
Brugia malayi mbt repeat family protein 0.0101 0.0346 0.0694
Loa Loa (eye worm) hypothetical protein 0.0115 0.0402 0.0806
Leishmania major hypothetical protein, conserved 0.0072 0.0232 0.0987
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0025 0.0046
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.1628 0.1626
Brugia malayi AMP-binding enzyme family protein 0.017 0.0621 0.1248
Brugia malayi fibroinase precursor 0.0138 0.0496 0.0995
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0046 0.0169
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0008
Brugia malayi cathepsin F-like cysteine proteinase 0.0138 0.0496 0.0995
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.009 0.0155
Echinococcus granulosus cathepsin b 0.1258 0.4955 0.8768
Onchocerca volvulus 0.0597 0.2324 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.0728 0.1464
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0028 0.0051
Echinococcus multilocularis muscleblind protein 1 0.0778 0.3043 0.3041
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0123 0.0434 0.0431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2324 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0597 0.2324 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0074 0.0145
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0036 0.0066
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0118 0.0496
Echinococcus granulosus cathepsin l1 0.0597 0.2324 0.411
Echinococcus granulosus pyruvate kinase 0.0036 0.0087 0.015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.012 0.0422 0.2356
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0154 0.0662
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0062 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0138 0.0496 0.2103
Schistosoma mansoni ap endonuclease 0.0058 0.0176 0.0306
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0118 0.0471
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0046 0.0087
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0154 0.0651
Leishmania major cathepsin L-like protease 0.0597 0.2324 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0186 0.0685 0.1378
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0176 0.1675
Echinococcus multilocularis SAM and MBT domain containing protein 0.0101 0.0346 0.0344
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0356 0.0714
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0028 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0046 0.0162
Toxoplasma gondii pyruvate kinase PyKII 0.0036 0.0087 0.0364
Echinococcus multilocularis snurportin 1 0.0334 0.1273 0.127
Leishmania major hypothetical protein, conserved 0.0026 0.0046 0.0185
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0026 0.0041
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0025 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0025 0.0109
Echinococcus granulosus peptidase Clp S14 family 0.0102 0.035 0.0615
Mycobacterium ulcerans acetyl-CoA synthetase 0.005 0.0143 0.1355
Echinococcus granulosus geminin 0.0687 0.2678 0.4738
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0028 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.0496 0.2103
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0025 0.004
Onchocerca volvulus Serine\/threonine kinase homolog 0.0195 0.0721 0.3077
Mycobacterium ulcerans lipase LipD 0.0072 0.0232 0.2218
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0018 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0325 0.1237 0.5305
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0028 0.0045
Brugia malayi beta-lactamase 0.0072 0.0232 0.0463
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0046 0.0087
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0025 0.0072
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0138 0.0496 0.0995
Echinococcus granulosus cathepsin l cysteine peptidase 0.0597 0.2324 0.411
Loa Loa (eye worm) hypothetical protein 0.0138 0.0496 0.0995
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0325 0.1237 0.5322
Giardia lamblia Cysteine protease 0.0138 0.0496 0.2571
Echinococcus multilocularis cathepsin L cysteine protease 0.0597 0.2324 0.2322
Brugia malayi cathepsin Z-like cysteine proteinase 0.0138 0.0496 0.0995
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0411 0.1583 0.319
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2324 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0325 0.1237 0.5322
Loa Loa (eye worm) hypothetical protein 0.0072 0.0232 0.0463
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0051
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0138 0.0496 0.211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.0496 0.2103
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0597 0.2324 0.4687
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.017 0.0621 0.3473
Loa Loa (eye worm) hypothetical protein 0.0072 0.0232 0.0463
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0028 0.0025
Schistosoma mansoni hypothetical protein 0.0021 0.0026 0.0041
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0082 0.0141
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0138 0.0496 0.2571
Brugia malayi jmjC domain containing protein 0.0059 0.0179 0.0356
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.005 0.0143 0.0786
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.005 0.0143 0.0786
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0009 0.0012
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0045 0.0156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2324 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0118 0.0232
Schistosoma mansoni pyruvate kinase 0.007 0.0223 0.039
Loa Loa (eye worm) hypothetical protein 0.0138 0.0496 0.0995
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1081 0.1079
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0028 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0496 0.2103
Giardia lamblia Cathepsin B precursor 0.0138 0.0496 0.2571
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.005 0.0143 0.1355
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.0496 0.2103
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.0508 0.102
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.0496 0.2103
Brugia malayi AMP-binding enzyme family protein 0.005 0.0143 0.0283
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0018 0.0032
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0045 0.0156
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0028 0.0084
Giardia lamblia Cathepsin L-like protease 0.0138 0.0496 0.2571
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Entamoeba histolytica cysteine protease, putative 0.0325 0.1237 0.5305
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0018 0.0032
Brugia malayi hypothetical protein 0.0016 0.001 0.0014
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1258 0.4955 0.8768
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0094 0.0185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.2324 1
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0043 0.0115 0.0631
Onchocerca volvulus 0.0597 0.2324 1
Giardia lamblia Pyruvate kinase 0.0036 0.0087 0.0371
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0018 0.0079
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0026 0.0023
Brugia malayi jmjC domain containing protein 0.0016 0.0007 0.0008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0028 0.0025
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0074 0.0145
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0028 0.0045
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0028 0.0045
Trypanosoma cruzi polo-like protein kinase, putative 0.0195 0.0721 0.1451
Echinococcus multilocularis geminin 0.0687 0.2678 0.2676
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0007 0.0007
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0176 0.0745
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.005 0.0143 0.0579
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0232 0.0972
Entamoeba histolytica cysteine proteinase, putative 0.0411 0.1583 0.6799
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0154 0.0627
Loa Loa (eye worm) pyruvate kinase-PB 0.0049 0.0139 0.0274
Brugia malayi cathepsin L-like precursor 0.0411 0.1583 0.319
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.017 0.0621 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0138 0.0496 0.2103
Plasmodium vivax unspecified product 0.0186 0.0685 0.2928
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0154 0.0627
Brugia malayi nuclear hormone receptor 0.0021 0.0028 0.0051
Plasmodium vivax acetyl-CoA synthetase, putative 0.005 0.0143 0.0588
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0036 0.0125
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0028 0.0045
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0028 0.0051
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0195 0.0721 0.3095
Schistosoma mansoni microtubule-associated protein tau 0.1433 0.565 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0138 0.0496 0.211
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0186 0.0369
Echinococcus granulosus SAM and MBT domain containing protein 0.0101 0.0346 0.0608
Echinococcus granulosus cathepsin b 0.1258 0.4955 0.8768
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2324 1
Loa Loa (eye worm) ctsf protein 0.0597 0.2324 0.4687
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0046 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0025 0.0109
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0028 0.0084
Loa Loa (eye worm) hypothetical protein 0.017 0.0621 0.1248
Loa Loa (eye worm) hypothetical protein 0.005 0.0143 0.0283
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0728 0.0725
Loa Loa (eye worm) hypothetical protein 0.0138 0.0496 0.0995
Loa Loa (eye worm) cathepsin B 0.0485 0.1875 0.378
Loa Loa (eye worm) oxidoreductase 0.005 0.0143 0.0283
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0485 0.1875 0.378
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0028 0.0025
Brugia malayi serine/threonine-protein kinase plk-2 0.0195 0.0721 0.1451
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0597 0.2324 1
Trypanosoma cruzi cysteine proteinase, putative 0.0325 0.1237 0.2492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Brugia malayi Cathepsin L-like precursor 0.0597 0.2324 0.4687
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2324 1
Leishmania major cathepsin L-like protease 0.0597 0.2324 1
Brugia malayi AMP-binding enzyme family protein 0.005 0.0143 0.0283
Echinococcus granulosus cathepsin L cysteine proteinase 0.0597 0.2324 0.411
Leishmania major cytochrome p450-like protein 0.0024 0.0039 0.0157
Entamoeba histolytica acyl-CoA synthetase, putative 0.017 0.0621 0.2644
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0143 0.1355
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0018 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0094 0.037
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.017 0.0621 0.5986
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0138 0.0496 0.2103
Brugia malayi Pyruvate kinase, muscle isozyme 0.007 0.0223 0.0445
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0028 0.0025
Onchocerca volvulus 0.017 0.0621 0.2644
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0138 0.0496 0.0873
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0508 0.0894
Schistosoma mansoni cathepsin F (C01 family) 0.0597 0.2324 0.411
Schistosoma mansoni rab6-interacting 0.0021 0.0026 0.0041
Schistosoma mansoni hypothetical protein 0.0033 0.0074 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.0496 0.2103
Echinococcus multilocularis pyruvate kinase 0.007 0.0223 0.022
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0154 0.0651
Schistosoma mansoni hypothetical protein 0.0626 0.2436 0.4309
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0138 0.0496 0.0995
Echinococcus granulosus pyruvate kinase 0.007 0.0223 0.039
Brugia malayi Cytochrome P450 family protein 0.0055 0.0161 0.032
Loa Loa (eye worm) pyruvate kinase 0.007 0.0223 0.0445
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0441 0.4244
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0176 0.073
Loa Loa (eye worm) hypothetical protein 0.0156 0.0564 0.1133
Entamoeba histolytica hypothetical protein 0.0138 0.0496 0.2103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2324 1
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0232 0.0463
Toxoplasma gondii cathepsin CPL 0.0597 0.2324 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0018 0.0016
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.005 0.0143 0.1355
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0154 0.0627
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1258 0.4955 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0138 0.0496 0.2103
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0173 0.0735
Plasmodium falciparum cysteine proteinase falcipain 1 0.0325 0.1237 0.5309
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0026 0.0023
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0138 0.0496 0.0873
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0195 0.0721 0.0719
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0195 0.0721 0.1272
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0028 0.0051
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0138 0.0496 0.211
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0143 0.0786
Schistosoma mansoni cpg binding protein 0.0031 0.0069 0.0117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2324 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0118 0.0471
Loa Loa (eye worm) hypothetical protein 0.0072 0.0232 0.0463
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0721 0.3077
Loa Loa (eye worm) hypothetical protein 0.0031 0.0068 0.0133
Echinococcus granulosus polycomb protein SCMH1 0.0101 0.0346 0.0608
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0028 0.0051
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0101 0.0346 0.1458
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0028 0.0051
Onchocerca volvulus 0.0597 0.2324 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0156 0.0564 1
Toxoplasma gondii pyruvate kinase PyK1 0.007 0.0223 0.0949
Echinococcus granulosus tumor protein p63 0.0345 0.1319 0.2331
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0721 0.3077
Echinococcus granulosus dna polymerase eta 0.002 0.0025 0.004
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0045 0.0156
Echinococcus granulosus cathepsin L cysteine protease 0.0325 0.1237 0.2185
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0138 0.0496 0.2571
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0028 0.0051
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0018 0.0032
Giardia lamblia Cathepsin L precursor 0.0138 0.0496 0.2571
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0232 0.0964
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.0508 0.102
Brugia malayi AMP-binding enzyme family protein 0.017 0.0621 0.1248
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0028 0.0045
Brugia malayi Papain family cysteine protease containing protein 0.0325 0.1237 0.2492
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0013 0.0019
Leishmania major pyruvate kinase 0.007 0.0223 0.0949
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0028 0.0045
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0115 0.0402 0.0399
Schistosoma mansoni kinase 0.0099 0.034 0.0597
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.005 0.0143 0.0283
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0232 0.0997
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0179 0.0176
Onchocerca volvulus 0.005 0.0143 0.0579
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0186 0.0324
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0025 0.0109
Trypanosoma cruzi cysteine peptidase, putative 0.0325 0.1237 0.2492
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.2324 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0138 0.0496 0.211
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0232 0.1287
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0232 0.1287
Leishmania major cathepsin L-like protease 0.0597 0.2324 1
Entamoeba histolytica cysteine protease, putative 0.0325 0.1237 0.5305
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.009 0.0155
Loa Loa (eye worm) mbt repeat family protein 0.0101 0.0346 0.0694
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.009 0.0155
Echinococcus multilocularis tumor protein p63 0.0345 0.1319 0.1317
Onchocerca volvulus Cathepsin F homolog 0.0597 0.2324 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.005 0.0143 0.0786
Onchocerca volvulus 0.003 0.0062 0.0231
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0046 0.0088
Echinococcus granulosus neuropeptide receptor A26 0.1433 0.565 0.9999
Plasmodium falciparum acyl-CoA synthetase 0.0127 0.045 0.1913
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0118 0.0232
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0046 0.0169
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0074 0.0072
Plasmodium vivax SET domain protein, putative 0.0037 0.009 0.0361
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0025 0.0218
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0508 0.0505
Loa Loa (eye worm) fibroinase 0.0597 0.2324 0.4687
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.0496 0.2103
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0025 0.0072
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0068 0.0283
Brugia malayi Importin beta-1 subunit 0.0031 0.0068 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0028 0.0051
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0054 0.0157 0.2503
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0421 0.0844
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0025 0.0109
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.005 0.0143 0.0786
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0176 0.0349
Giardia lamblia Kinase, PLK 0.0195 0.0721 0.3786
Entamoeba histolytica cysteine protease, putative 0.0325 0.1237 0.5305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Echinococcus granulosus cathepsin l1 0.0411 0.1583 0.2797
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0094 0.0092
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0028 0.0045
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0101 0.0346 0.0608
Onchocerca volvulus 0.0072 0.0232 0.0964
Echinococcus granulosus cysteine protease 0.0325 0.1237 0.2185
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0721 0.3077
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0045 0.0085
Plasmodium vivax unspecified product 0.0138 0.0496 0.211
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.005 0.0143 0.0283
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0036 0.0033
Echinococcus multilocularis cathepsin b 0.1258 0.4955 0.4953
Trypanosoma cruzi pyruvate kinase 2, putative 0.007 0.0223 0.0445
Trichomonas vaginalis pyruvate kinase, putative 0.007 0.0223 0.0926
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0176 0.0972
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0025 0.0046
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0154 0.0305
Entamoeba histolytica cysteine proteinase, putative 0.0325 0.1237 0.5305
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0186 0.0324
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0094 0.037
Mycobacterium ulcerans pyruvate kinase 0.007 0.0223 0.2133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2324 1
Giardia lamblia Cathepsin L precursor 0.0138 0.0496 0.2571
Brugia malayi Pre-SET motif family protein 0.0037 0.009 0.0176
Entamoeba histolytica Ran family GTPase 0.0023 0.0036 0.0116
Loa Loa (eye worm) hypothetical protein 0.0127 0.045 0.0903
Schistosoma mansoni sex comb on midleg homolog 0.0101 0.0346 0.0608
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0123 0.0434 0.0763
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0138 0.0496 0.0873
Plasmodium falciparum serine repeat antigen 1 0.0138 0.0496 0.211
Mycobacterium tuberculosis Conserved protein 0.0072 0.0232 0.1287
Loa Loa (eye worm) hypothetical protein 0.0101 0.0346 0.0694
Schistosoma mansoni ran 0.0023 0.0036 0.0058
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.005 0.0143 0.0603
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0138 0.0496 0.211
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0197 0.0194
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0197 0.0344
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.017 0.0621 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.017 0.0621 0.5986
Plasmodium falciparum serine repeat antigen 2 0.0138 0.0496 0.211
Trypanosoma brucei acetyl-CoA synthetase, putative 0.005 0.0143 0.0614
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0115 0.0402 0.0707
Giardia lamblia Cathepsin B precursor 0.0138 0.0496 0.2571
Brugia malayi jmjC domain containing protein 0.0016 0.0007 0.0008
Echinococcus multilocularis RUN 0.0021 0.0026 0.0023
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0019 0.0032
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0036 0.0125
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0026 0.0023
Brugia malayi ecdysteroid receptor 0.0021 0.0028 0.0051
Echinococcus multilocularis pyruvate kinase 0.0036 0.0087 0.0085
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.005 0.0143 0.014
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0028 0.0045
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0154 0.0151
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0232 0.1287
Toxoplasma gondii exonuclease III APE 0.0058 0.0176 0.0745
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0028 0.0051
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0074 0.0127
Schistosoma mansoni hypothetical protein 0.0334 0.1273 0.2249
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0036 0.0066
Toxoplasma gondii ABC1 family protein 0.0072 0.0232 0.0987
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0232 0.0964
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0441 0.4244
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0018 0.0068
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.005 0.0143 0.1355
Schistosoma mansoni loxhd1 0.0021 0.0026 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0028 0.0051
Loa Loa (eye worm) hypothetical protein 0.0138 0.0496 0.0995
Plasmodium vivax serine-repeat antigen (SERA) 0.0138 0.0496 0.211
Entamoeba histolytica cysteine protease, putative 0.0138 0.0496 0.2103
Brugia malayi Cytochrome P450 family protein 0.0024 0.0039 0.0073
Echinococcus granulosus cpg binding protein 0.0031 0.0069 0.0117
Schistosoma mansoni lipoxygenase 0.0123 0.0434 0.0763
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2324 1
Loa Loa (eye worm) hypothetical protein 0.0186 0.0685 0.1378
Toxoplasma gondii cathepsin B 0.0485 0.1875 0.8065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2324 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0197 0.0344
Echinococcus multilocularis cathepsin L cysteine protease 0.0597 0.2324 0.2322
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0138 0.0496 0.0873
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0068 0.0294
Echinococcus multilocularis pyruvate kinase 0.0036 0.0087 0.0085
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0143 0.1355
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0046 0.0199
Echinococcus multilocularis peptidase Clp (S14 family) 0.0102 0.035 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0118 0.0471
Brugia malayi Cathepsin L-like precursor 0.0411 0.1583 0.319
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0485 0.1875 0.806
Echinococcus multilocularis histone acetyltransferase MYST2 0.0115 0.0402 0.0399
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.041 0.1576 0.1574
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0325 0.1237 0.2492
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0039 0.0073
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0025 0.0109
Onchocerca volvulus 0.0072 0.0232 0.0964
Brugia malayi RNA, U transporter 1 0.0089 0.0298 0.0596
Giardia lamblia Cathepsin B precursor 0.0138 0.0496 0.2571
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0138 0.0496 0.2103
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0051
Loa Loa (eye worm) hypothetical protein 0.0127 0.045 0.0903
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0325 0.1237 0.5305
Loa Loa (eye worm) hypothetical protein 0.017 0.0621 0.1248
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0127 0.045 0.0903
Schistosoma mansoni hypothetical protein 0.0071 0.0226 0.0395
Mycobacterium ulcerans hypothetical protein 0.0072 0.0232 0.2218
Giardia lamblia Cathepsin L-like protease 0.0138 0.0496 0.2571
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0028 0.0051
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0028 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0102 0.035 0.5621
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0411 0.1583 0.6799
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0007 0.0008
Entamoeba histolytica cysteine protease, putative 0.0325 0.1237 0.5305
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0008
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0074 0.0127
Echinococcus granulosus importin subunit beta 1 0.0031 0.0068 0.0116
Loa Loa (eye worm) pyruvate kinase 0.0015 0.0003 0.000005198
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.012 0.0422 0.2356
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0026 0.0083
Giardia lamblia Cathepsin B precursor 0.0485 0.1875 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0118 0.0471
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0156 0.0564 0.2417
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0025 0.0023
Onchocerca volvulus Pyruvate kinase homolog 0.007 0.0223 0.0926
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0156 0.0564 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.009 0.0155
Trypanosoma cruzi cysteine protease, putative 0.0325 0.1237 0.2492
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0102 0.035 0.1952
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0179 0.0312
Toxoplasma gondii hypothetical protein 0.0054 0.0157 0.0667
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0176 0.0848
Mycobacterium leprae Probable lipase LipE 0.0072 0.0232 0.3705
Toxoplasma gondii propionate-CoA ligase 0.005 0.0143 0.0603
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0197 0.0344
Trypanosoma cruzi cysteine peptidase, putative 0.0597 0.2324 0.4687
Brugia malayi nuclear receptor NHR-88 0.0021 0.0028 0.0051
Echinococcus multilocularis GPCR, family 2 0.0033 0.0074 0.0072
Loa Loa (eye worm) hypothetical protein 0.0103 0.0356 0.0714
Plasmodium vivax vivapain-2 0.0597 0.2324 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2324 1
Onchocerca volvulus 0.0597 0.2324 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0018 0.0032
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0028 0.0051
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0232 0.3705
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0232 0.0463
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0356 0.0714
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0025 0.0218
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0179 0.0312
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0138 0.0496 0.2103
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0068 0.0294
Plasmodium vivax vivapain-3 0.0325 0.1237 0.5309
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0028 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0143 0.1355
Entamoeba histolytica cysteine proteinase, putative 0.0597 0.2324 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.005 0.0143 0.0603
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0025 0.0109
Loa Loa (eye worm) AMP-binding enzyme family protein 0.005 0.0143 0.0283
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0025 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2324 1
Leishmania major pyruvate kinase 0.007 0.0223 0.0949
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0118 0.0471
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0009 0.0037
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0186 0.0685 0.1378
Entamoeba histolytica cysteine protease, putative 0.0138 0.0496 0.2103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2324 1
Onchocerca volvulus Cathepsin L homolog 0.0138 0.0496 0.2103
Onchocerca volvulus 0.0597 0.2324 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0156 0.0564 0.5432
Onchocerca volvulus Pyruvate kinase homolog 0.007 0.0223 0.0926
Onchocerca volvulus 0.0051 0.0145 0.059
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.0948 0.1908
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.2324 1
Toxoplasma gondii cathepsin CPC1 0.0138 0.0496 0.2123
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0197 0.0344
Trypanosoma cruzi cruzipain precursor, putative 0.0597 0.2324 0.4687
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0028 0.0045
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0356 0.0714
Brugia malayi Cathepsin L-like precursor 0.0411 0.1583 0.319
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0118 0.0496
Echinococcus multilocularis cathepsin b 0.1258 0.4955 0.4953
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0028 0.0045
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0721 0.3077
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.009 0.0377
Entamoeba histolytica cysteine proteinase, putative 0.0597 0.2324 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0139 0.0274
Plasmodium falciparum pyruvate kinase 0.007 0.0223 0.0934
Plasmodium falciparum serine repeat antigen 3 0.0138 0.0496 0.211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0597 0.2324 1
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0007 0.0007
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0036 0.0153
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0039 0.0168
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0039 0.0073
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1258 0.4955 0.8768
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0232 0.0463
Giardia lamblia Cathepsin B precursor 0.0138 0.0496 0.2571
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0232 0.1287
Brugia malayi Cathepsin L-like precursor 0.0186 0.0685 0.1378
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0118 0.0471
Schistosoma mansoni hypothetical protein 0.0058 0.0176 0.0307
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0007 0.0028
Brugia malayi Cathepsin L-like precursor 0.0597 0.2324 0.4687
Loa Loa (eye worm) hypothetical protein 0.0411 0.1583 0.319
Loa Loa (eye worm) beta-lactamase 0.0072 0.0232 0.0463
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0232 0.2218
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0118 0.0471
Loa Loa (eye worm) hypothetical protein 0.017 0.0621 0.1248
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0125 0.0441 0.1889
Mycobacterium tuberculosis Conserved protein 0.0072 0.0232 0.1287
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0597 0.2324 0.4687
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0232 0.0964
Plasmodium falciparum pyruvate kinase 2 0.0036 0.0087 0.0348
Leishmania major importin beta-1 subunit, putative 0.0025 0.0045 0.0182
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0094 0.041
Loa Loa (eye worm) hypothetical protein 0.1258 0.4955 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0138 0.0496 0.2571
Giardia lamblia Cathepsin B precursor 0.0485 0.1875 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0018 0.0068
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.0721 0.1272
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0094 0.0092
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.005 0.0143 0.0283
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.005 0.0143 0.1355
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0115 0.0402 0.0806
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.0496 0.2103
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0039 0.0073
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.005 0.0143 0.0786
Entamoeba histolytica cysteine protease, putative 0.0597 0.2324 1
Brugia malayi hypothetical protein 0.0026 0.0046 0.0087
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0009 0.0012
Leishmania major cathepsin L-like protease 0.0597 0.2324 1
Schistosoma mansoni hypothetical protein 0.0033 0.0074 0.0127
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1258 0.4955 0.8768
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.2324 1
Brugia malayi Pre-SET motif family protein 0.0252 0.0948 0.1908
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0028 0.0045
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0157 0.0651
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.2324 1
Brugia malayi hypothetical protein 0.0021 0.0026 0.0047
Echinococcus granulosus pyruvate kinase 0.0036 0.0087 0.015
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0125 0.0441 0.2462
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0018 0.0016
Plasmodium vivax vivapain-1 0.0325 0.1237 0.5309
Plasmodium falciparum serine repeat antigen 9 0.0138 0.0496 0.211
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0094 0.037
Entamoeba histolytica cysteine protease, putative 0.0325 0.1237 0.5305
Brugia malayi Cathepsin L-like precursor 0.0597 0.2324 0.4687
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.005 0.0143 0.0283
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0597 0.2324 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0138 0.0496 0.0995
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0046 0.0077
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0154 0.073
Trypanosoma cruzi major cysteine proteinase, putative 0.0138 0.0496 0.0995
Echinococcus multilocularis cathepsin L 0.0138 0.0496 0.0493
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0143 0.1355
Schistosoma mansoni acetyl-CoA synthetase 0.005 0.0143 0.0248
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0046 0.0077
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0071 0.0226 0.045
Echinococcus multilocularis microtubule associated protein 2 0.1433 0.565 0.5649
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.007 0.0223 0.1238
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0143 0.0786
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2324 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.017 0.0621 0.5986
Entamoeba histolytica cysteine protease, putative 0.0325 0.1237 0.5305
Onchocerca volvulus 0.0597 0.2324 1
Echinococcus granulosus muscleblind protein 0.0778 0.3043 0.5383
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.012 0.0422 0.2356
Schistosoma mansoni ran 0.0023 0.0036 0.0058
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0012
Brugia malayi glutaminase DH11.1 0.0274 0.1036 0.2086
Brugia malayi acetyl-Coenzyme A synthetase 2 0.005 0.0143 0.0283
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0025 0.0109
Loa Loa (eye worm) hypothetical protein 0.0127 0.045 0.0903
Trichomonas vaginalis antibiotic synthetase, putative 0.005 0.0143 0.0579
Brugia malayi pyruvate kinase 0.0015 0.0003 0.000005198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0508 0.0894
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0028 0.0045
Leishmania major GTP-binding protein, putative 0.0023 0.0036 0.0141
Trypanosoma cruzi cysteine peptidase, putative 0.0597 0.2324 0.4687
Trichomonas vaginalis antibiotic synthetase, putative 0.005 0.0143 0.0579
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0025 0.0046
Trypanosoma brucei polo-like protein kinase 0.0195 0.0721 0.3103
Onchocerca volvulus Cathepsin L homolog 0.0597 0.2324 1
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0007 0.0007
Entamoeba histolytica cysteine protease, putative 0.0325 0.1237 0.5305
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0138 0.0496 0.0873
Giardia lamblia Cysteine protease 0.0138 0.0496 0.2571
Brugia malayi beta-lactamase family protein 0.0072 0.0232 0.0463
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0018 0.0079
Giardia lamblia Cysteine protease 0.0138 0.0496 0.2571
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0018 0.0079
Brugia malayi hypothetical protein 0.0286 0.1081 0.2178
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0036 0.0066
Giardia lamblia Cathepsin B precursor 0.0485 0.1875 1
Brugia malayi CXXC zinc finger family protein 0.003 0.0062 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0025 0.0109
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0496 0.2103
Brugia malayi Doublecortin family protein 0.0021 0.0026 0.0047
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.005 0.0143 0.1355
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1081 0.191
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0028 0.0051
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0485 0.1875 0.8065
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0597 0.2324 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0018 0.0032
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0138 0.0496 0.211
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0028 0.0045
Loa Loa (eye worm) hypothetical protein 0.0022 0.0032 0.0059
Brugia malayi steroid hormone receptor 0.0021 0.0028 0.0051
Loa Loa (eye worm) hypothetical protein 0.0051 0.0145 0.0288
Brugia malayi hypothetical protein 0.0021 0.0026 0.0047
Echinococcus multilocularis pyruvate kinase 0.0055 0.0164 0.0162
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0018 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0028 0.0051
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.005 0.0143 0.0603
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0138 0.0496 0.211
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0019 0.0068
Echinococcus multilocularis pyruvate kinase 0.0036 0.0087 0.0085
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0154 0.0151
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0508 0.0505
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0046 0.0185
Brugia malayi Pyruvate kinase, M2 isozyme 0.007 0.0223 0.0445
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0156 0.0564 0.2404
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0102 0.035 0.1952
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0154 0.0627
Echinococcus granulosus microtubule associated protein 2 0.1433 0.565 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0094 0.0395
Entamoeba histolytica cysteine protease, putative 0.0138 0.0496 0.2103
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0094 0.0162
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0018 0.0028
Trypanosoma brucei protein kinase, putative 0.0053 0.0154 0.0662
Brugia malayi Papain family cysteine protease containing protein 0.0138 0.0496 0.0995
Loa Loa (eye worm) hypothetical protein 0.0072 0.0232 0.0463
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0118 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0039 0.0073
Giardia lamblia Encystation-specific protease 0.0138 0.0496 0.2571
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0018 0.0032
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0009 0.0026
Echinococcus granulosus RUN 0.0021 0.0026 0.0041
Onchocerca volvulus 0.0411 0.1583 0.6799
Giardia lamblia DINP protein human, muc B family 0.002 0.0025 0.0037
Schistosoma mansoni hypothetical protein 0.0687 0.2678 0.4738
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0007 0.0004
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0025 0.0072
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0018 0.0068
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0197 0.0344
Leishmania major cathepsin L-like protease 0.0597 0.2324 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0138 0.0496 0.2571
Echinococcus granulosus endonuclease exonuclease phosphatase 0.041 0.1576 0.2786
Entamoeba histolytica cysteine protease, putative 0.0138 0.0496 0.2103
Entamoeba histolytica acyl-CoA synthetase, putative 0.017 0.0621 0.2644
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0441 0.4244
Plasmodium vivax acyl-CoA synthetase, putative 0.0127 0.045 0.1913
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0232 0.1287
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0127 0.045 0.4329
Giardia lamblia Pyruvate kinase 0.007 0.0223 0.1102
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0118 0.0471
Schistosoma mansoni cathepsin B (C01 family) 0.0138 0.0496 0.0873
Schistosoma mansoni cpg binding protein 0.0031 0.0069 0.0117
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0094 0.0406
Onchocerca volvulus 0.0597 0.2324 1
Onchocerca volvulus 0.0021 0.0026 0.0074
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0051
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0156 0.0564 0.2404
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0025 0.004
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0154 0.0305
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0094 0.0185
Echinococcus multilocularis polycomb protein SCMH1 0.0101 0.0346 0.0344
Entamoeba histolytica cysteine protease, putative 0.0325 0.1237 0.5305
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0068 0.0066
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0028 0.0045
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0046 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.033 0.1386
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0138 0.0496 0.0873
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0025 0.0109
Echinococcus multilocularis cpg binding protein 0.0031 0.0069 0.0066
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.005 0.0143 0.0786
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0485 0.1875 0.3315
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.02 0.0349
Brugia malayi Muscleblind-like protein 0.0778 0.3043 0.614
Brugia malayi AMP-binding enzyme family protein 0.005 0.0143 0.0283
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0138 0.0496 0.211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0039 0.0073
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0143 0.0786
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.033 0.1386
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0032 0.0059
Loa Loa (eye worm) hypothetical protein 0.0411 0.1583 0.319
Trypanosoma cruzi cysteine peptidase, putative 0.0186 0.0685 0.1378
Echinococcus granulosus pyruvate kinase 0.007 0.0223 0.039
Plasmodium vivax unspecified product 0.0325 0.1237 0.5309
Leishmania major acetyl-CoA synthetase, putative 0.005 0.0143 0.0603
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0127 0.045 0.6655
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0176 0.0349
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0018 0.0079
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0232 0.0406
Echinococcus granulosus neuropeptide s receptor 0.1433 0.565 0.9999
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0156 0.0564 0.5432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0125 0.0441 0.0438
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0232 0.0964
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0028 0.0045
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0176 0.0349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Giardia lamblia Hypothetical protein 0.0138 0.0496 0.2571
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.005 0.0143 0.0283
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0025 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0025 0.0109
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.005 0.0143 0.0614
Trypanosoma cruzi polo-like protein kinase, putative 0.0195 0.0721 0.1451
Mycobacterium ulcerans acyl-CoA synthetase 0.017 0.0621 0.5986
Brugia malayi TAR-binding protein 0.0064 0.0197 0.0392
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0028 0.0051
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0007 0.0008
Loa Loa (eye worm) cysteine protease 0.0597 0.2324 0.4687
Trypanosoma brucei glucosidase, putative 0.0044 0.0118 0.0507
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0161 0.032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2324 1
Entamoeba histolytica cysteine protease, putative 0.0325 0.1237 0.5305
Echinococcus granulosus GPCR family 2 0.0033 0.0074 0.0127
Trypanosoma brucei pyruvate kinase 1 0.007 0.0223 0.096
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.0728 0.1464
Onchocerca volvulus 0.0021 0.0028 0.0084
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0018 0.0028
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0232 0.0406
Brugia malayi mbt repeat family protein 0.0101 0.0346 0.0694
Schistosoma mansoni importin beta-1 0.0031 0.0068 0.0116
Trypanosoma brucei cysteine peptidase C (CPC) 0.0485 0.1875 0.8067
Loa Loa (eye worm) hypothetical protein 0.0411 0.1583 0.319
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0118 0.0471
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0138 0.0496 0.211
Echinococcus multilocularis neuropeptide s receptor 0.1433 0.565 0.5649
Plasmodium falciparum serine repeat antigen 8 0.0138 0.0496 0.211
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0176 0.0306
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0154 0.0268
Brugia malayi cathepsin Z-like cysteine proteinase 0.0138 0.0496 0.0995
Giardia lamblia Cathepsin L precursor 0.0138 0.0496 0.2571
Brugia malayi AMP-binding enzyme family protein 0.017 0.0621 0.1248
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0195 0.0721 0.1451
Loa Loa (eye worm) hypothetical protein 0.0033 0.0074 0.0145
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0025 0.0097
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0176 0.0721
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0025 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.0496 0.2103
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0143 0.1355
Schistosoma mansoni cathepsin s 0.0186 0.0685 0.1208
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0026 0.0047
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0036 0.0058
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.005 0.0143 0.0248
Schistosoma mansoni myelin transcription factor 1 myt1 0.0115 0.0402 0.0707
Giardia lamblia Cathepsin L precursor 0.0138 0.0496 0.2571
Leishmania major cathepsin L-like protease 0.0597 0.2324 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0118 0.0204
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0028 0.0045
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0186 0.0324
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0094 0.0162
Onchocerca volvulus 0.0072 0.0232 0.0964
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0028 0.0045
Plasmodium falciparum serine repeat antigen 6 0.0138 0.0496 0.211
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0138 0.0496 0.211
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0176 0.0721
Entamoeba histolytica cysteine proteinase 2 0.0325 0.1237 0.5305
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0143 0.1355
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0138 0.0496 0.211
Entamoeba histolytica cysteine proteinase, putative 0.0325 0.1237 0.5305
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0325 0.1237 0.2185
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0176 0.0449
Onchocerca volvulus Cathepsin L homolog 0.0597 0.2324 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0046 0.0169
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0508 0.0894
Brugia malayi MAP kinase sur-1 0.0053 0.0154 0.0305
Schistosoma mansoni cathepsin F (C01 family) 0.0411 0.1583 0.2797
Brugia malayi Papain family cysteine protease containing protein 0.0597 0.2324 0.4687
Giardia lamblia Cathepsin B precursor 0.0138 0.0496 0.2571
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0462 0.1783 1
Schistosoma mansoni hypothetical protein 0.0033 0.0074 0.0127
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0721 0.3077
Echinococcus multilocularis neuropeptide receptor A26 0.1433 0.565 0.5649
Leishmania major hypothetical protein, conserved 0.0016 0.0007 0.0017
Mycobacterium ulcerans hypothetical protein 0.017 0.0621 0.5986
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0026 0.0041
Schistosoma mansoni cathepsin C 0.0138 0.0496 0.0873
Mycobacterium leprae Probable pyruvate kinase PykA 0.007 0.0223 0.3564
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0018 0.0028
Loa Loa (eye worm) hypothetical protein 0.0038 0.0094 0.0185
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.005 0.0143 0.2264
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.005 0.0143 0.1355
Leishmania major 4-coumarate:coa ligase-like protein 0.017 0.0621 0.2663
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0232 0.1287
Echinococcus granulosus phd:f box containing protein 0.0016 0.0007 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0028 0.0045
Echinococcus multilocularis cysteine protease 0.0597 0.2324 0.2322
Loa Loa (eye worm) hypothetical protein 0.0026 0.0046 0.0087
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0597 0.2324 0.2322
Brugia malayi Probable ClpP-like protease 0.0156 0.0564 0.1133
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0028 0.0025
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0441 0.0776
Mycobacterium ulcerans glutaminase 0.0274 0.1036 1
Entamoeba histolytica cysteine protease, putative 0.0325 0.1237 0.5305
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0094 0.0162
Entamoeba histolytica hypothetical protein 0.0026 0.0046 0.0162
Loa Loa (eye worm) hypothetical protein 0.0778 0.3043 0.614
Schistosoma mansoni rab6-interacting 0.0021 0.0026 0.0041
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0156 0.0564 0.0993
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0143 0.1355
Echinococcus multilocularis cysteine protease 0.0597 0.2324 0.2322
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0508 0.0894
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.012 0.0422 0.2356
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0028 0.0051
Echinococcus granulosus cathepsin L 0.0138 0.0496 0.0873
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0094 0.0162
Mycobacterium ulcerans acyl-CoA synthetase 0.017 0.0621 0.5986
Brugia malayi beta-lactamase family protein 0.0072 0.0232 0.0463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0125 0.0441 0.0776
Leishmania major cathepsin L-like protease 0.0597 0.2324 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0597 0.2324 1
Schistosoma mansoni hypothetical protein 0.0687 0.2678 0.4738
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0197 0.0392
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0025 0.0109
Plasmodium vivax importin-beta 2, putative 0.0031 0.0068 0.0267
Plasmodium falciparum acetyl-CoA synthetase, putative 0.005 0.0143 0.0588
Toxoplasma gondii preprocathepsin c precursor, putative 0.0138 0.0496 0.2123
Loa Loa (eye worm) hypothetical protein 0.0037 0.009 0.0176
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0156 0.0564 0.9075
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0176 0.0173
Trypanosoma cruzi pyruvate kinase 2, putative 0.007 0.0223 0.0445
Toxoplasma gondii cathepsin CPC2 0.0138 0.0496 0.2123
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0197 0.0392
Entamoeba histolytica acyl-coA synthetase, putative 0.017 0.0621 0.2644
Loa Loa (eye worm) hypothetical protein 0.005 0.0143 0.0283
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0018 0.0032
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0118 0.0471
Loa Loa (eye worm) AMP-binding enzyme family protein 0.005 0.0143 0.0283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Schistosoma mansoni pyruvate kinase 0.007 0.0223 0.039
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0143 0.1355
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0019 0.0018 0.0032
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0007 0.0007
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0176 0.0349
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.005 0.0143 0.0786
Trypanosoma cruzi major cysteine proteinase, putative 0.0138 0.0496 0.0995
Trypanosoma cruzi cysteine proteinase, putative 0.0325 0.1237 0.2492
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0028 0.0051
Entamoeba histolytica cysteine proteinase 1, putative 0.0325 0.1237 0.5305
Schistosoma mansoni hypothetical protein 0.0033 0.0074 0.0127
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0154 0.0305
Echinococcus granulosus histone acetyltransferase MYST2 0.0115 0.0402 0.0707
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Schistosoma mansoni DNA polymerase eta 0.002 0.0025 0.004
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0232 0.1287
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0007 0.0008
Plasmodium falciparum serine repeat antigen 4 0.0138 0.0496 0.211
Loa Loa (eye worm) RNA binding protein 0.0064 0.0197 0.0392
Giardia lamblia Hypothetical protein 0.0138 0.0496 0.2571
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0176 0.073
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.009 0.0087
Brugia malayi cathepsin F-like cysteine proteinase 0.0186 0.0685 0.1378
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0138 0.0496 0.0873
Schistosoma mansoni peptidase Clp (S14 family) 0.0156 0.0564 0.0993
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0138 0.0496 0.2103
Echinococcus granulosus tar DNA binding protein 0.0064 0.0197 0.0344
Brugia malayi AMP-binding enzyme family protein 0.005 0.0143 0.0283
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0007 0.0004
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0118 0.0115
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0138 0.0496 0.0995
Plasmodium vivax pyruvate kinase 2, putative 0.0036 0.0087 0.0348
Onchocerca volvulus 0.0287 0.1086 0.4653
Onchocerca volvulus 0.005 0.0143 0.0579
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0018 0.0032
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.017 0.0621 0.3473
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0597 0.2324 0.2322
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0028 0.0025
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0036 0.0066
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0154 0.0651
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.005 0.0143 0.1355
Loa Loa (eye worm) hypothetical protein 0.007 0.0223 0.0445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0074 0.0145
Leishmania major 4-coumarate:coa ligase-like protein 0.017 0.0621 0.2663
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.009 0.0155
Trypanosoma brucei unspecified product 0.002 0.0025 0.0109
Schistosoma mansoni alpha-glucosidase 0.0169 0.0618 0.109
Leishmania major cysteine peptidase A (CPA) 0.0597 0.2324 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0156 0.0564 0.0561
Leishmania major DNA polymerase eta, putative 0.002 0.0025 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0138 0.0496 0.2103
Schistosoma mansoni sex comb on midleg homolog 0.0101 0.0346 0.0608
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0028 0.0051
Onchocerca volvulus 0.0138 0.0496 0.2103
Schistosoma mansoni cathepsin S (C01 family) 0.0138 0.0496 0.0873
Loa Loa (eye worm) hypothetical protein 0.0127 0.045 0.0903
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0007 0.0008
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0154 0.0305
Brugia malayi jmjC domain containing protein 0.0016 0.0007 0.0008
Plasmodium vivax serine-repeat antigen (SERA) 0.0138 0.0496 0.211
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0138 0.0496 0.0873
Echinococcus multilocularis pyruvate kinase 0.007 0.0223 0.022
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0179 0.0176
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0176 0.0721
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0597 0.2324 1
Echinococcus granulosus pyruvate kinase 0.0036 0.0087 0.015
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0118 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0018 0.0042
Giardia lamblia Cathepsin L precursor 0.0138 0.0496 0.2571
Onchocerca volvulus 0.005 0.0143 0.0579
Brugia malayi Cathepsin L-like cysteine proteinase 0.0411 0.1583 0.319
Mycobacterium tuberculosis Conserved protein 0.0072 0.0232 0.1287
Giardia lamblia Cathepsin L precursor 0.0138 0.0496 0.2571
Plasmodium vivax pyruvate kinase, putative 0.007 0.0223 0.0934
Entamoeba histolytica cysteine protease, putative 0.0138 0.0496 0.2103
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0197 0.0392
Leishmania major pantothenate kinase subunit, putative 0.0019 0.0018 0.0067
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0143 0.2264
Brugia malayi RNA binding protein 0.0064 0.0197 0.0392
Plasmodium vivax vivapain-2 0.0597 0.2324 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0028 0.0045
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1258 0.4955 0.8768
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0009 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.017 0.0621 0.5986
Schistosoma mansoni alpha glucosidase 0.0044 0.0118 0.0204
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0046 0.0044
Onchocerca volvulus 0.0058 0.0176 0.0722
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0028 0.0051
Echinococcus multilocularis muscleblind protein 0.0778 0.3043 0.3041
Brugia malayi cathepsin L precursor 0.0138 0.0496 0.0995
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.0728 0.1284
Loa Loa (eye worm) MBCTL1 0.0115 0.0402 0.0806
Brugia malayi Papain family cysteine protease containing protein 0.0138 0.0496 0.0995
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0143 0.1355
Entamoeba histolytica serine/threonine protein kinase, putative 0.0195 0.0721 0.3077
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0007 0.0004
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0007 0.0017
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0325 0.1237 0.2185
Brugia malayi cathepsin L-like cysteine proteinase 0.0138 0.0496 0.0995
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0118 0.0471
Mycobacterium ulcerans beta-lactamase 0.0072 0.0232 0.2218
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0026 0.0083
Entamoeba histolytica cysteine proteinase, putative 0.0325 0.1237 0.5305

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0032 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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