Detailed information for compound 1312797

Basic information

Technical information
  • TDR Targets ID: 1312797
  • Name: N-[1-(cyclohexylamino)-1-oxobutan-2-yl]-N'-(5 -methyl-1,2-oxazol-3-yl)-N-(thiophen-2-ylmeth yl)butanediamide
  • MW: 460.59 | Formula: C23H32N4O4S
  • H donors: 2 H acceptors: 4 LogP: 2.94 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(N(C(=O)CCC(=O)Nc1noc(c1)C)Cc1cccs1)C(=O)NC1CCCCC1
  • InChi: 1S/C23H32N4O4S/c1-3-19(23(30)24-17-8-5-4-6-9-17)27(15-18-10-7-13-32-18)22(29)12-11-21(28)25-20-14-16(2)31-26-20/h7,10,13-14,17,19H,3-6,8-9,11-12,15H2,1-2H3,(H,24,30)(H,25,26,28)
  • InChiKey: PCTWWHGTGGNPIA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[1-(cyclohexylcarbamoyl)propyl]-N'-(5-methylisoxazol-3-yl)-N-(2-thienylmethyl)butanediamide
  • N-[1-[(cyclohexylamino)-oxomethyl]propyl]-N'-(5-methyl-3-isoxazolyl)-N-(2-thienylmethyl)butanediamide
  • N-[1-(cyclohexylcarbamoyl)propyl]-N'-(5-methylisoxazol-3-yl)-N-(2-thienylmethyl)succinamide
  • N-[1-(cyclohexylamino)-1-oxo-butan-2-yl]-N'-(5-methyl-1,2-oxazol-3-yl)-N-(thiophen-2-ylmethyl)butanediamide
  • ASN 06264803

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0122 0.0641
Brugia malayi RNA recognition motif domain containing protein 0.0268 0.0516 0.2686
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0025 0.0138
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0037
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.002 0.0012 0.0063
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0043 0.0058 0.0335
Schistosoma mansoni alpha-glucosidase 0.0149 0.0275 0.1627
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0018 0.005
Loa Loa (eye worm) steroid hormone receptor 0.0091 0.0156 0.081
Brugia malayi hypothetical protein 0.0329 0.064 0.333
Brugia malayi Probable ClpP-like protease 0.0076 0.0126 0.0654
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0129
Schistosoma mansoni cellular tumor antigen P53 0.0151 0.0277 0.1643
Brugia malayi Inositol-1 0.0038 0.0048 0.0249
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0302
Echinococcus multilocularis acylamino acid releasing enzyme 0.0027 0.0025 0.0023
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0072 0.0163
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0028
Echinococcus multilocularis microtubule associated protein 2 0.0697 0.139 0.1388
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0018 0.0098
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0019 0.0474
Schistosoma mansoni thyroid hormone receptor 0.0091 0.0156 0.0917
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.002 0.0012 0.001
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.001
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.0324 0.0322
Echinococcus granulosus nuclear receptor nhr 48 0.0043 0.0058 0.0272
Brugia malayi jmjC domain containing protein 0.0035 0.0042 0.0217
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0302
Loa Loa (eye worm) hypothetical protein 0.0276 0.0532 0.2769
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Leishmania major RNA-editing complex protein MP100, putative 0.0015 0.0002 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0019 0.0054
Giardia lamblia DINP protein human, muc B family 0.0023 0.0018 0.1338
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0039 0.0051 0.0798
Schistosoma mansoni lamin 0.0135 0.0245 0.1452
Schistosoma mansoni coup transcription factor 0.0091 0.0156 0.0917
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0025 0.0392
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0102 0.2497
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0446
Schistosoma mansoni intermediate filament proteins 0.0135 0.0245 0.1452
Loa Loa (eye worm) hypothetical protein 0.0128 0.0231 0.12
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0123 0.0722
Loa Loa (eye worm) fibroinase 0.0017 0.0005 0.0028
Brugia malayi Smad1 0.0026 0.0023 0.0119
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0302
Brugia malayi hypothetical protein 0.0171 0.0319 0.166
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.002 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0051 0.0266
Schistosoma mansoni importin beta-1 0.0035 0.0042 0.0238
Entamoeba histolytica cysteine protease, putative 0.0017 0.0005 0.0083
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0048 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Brugia malayi intermediate filament protein 0.0135 0.0245 0.1277
Echinococcus granulosus prolyl endopeptidase 0.0027 0.0025 0.0112
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0002 0.001
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.002 0.0012 0.0063
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0153
Echinococcus granulosus survival motor neuron protein 1 0.0958 0.1921 0.93
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.0122 0.2989
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0007 0.0037
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0048 0.0223
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0042 0.0217
Brugia malayi nuclear hormone receptor 0.0091 0.0156 0.081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.2497
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0074 0.0122 0.0637
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Onchocerca volvulus Prolyl endopeptidase homolog 0.0027 0.0025 0.0131
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0024 0.1802
Echinococcus granulosus guanine nucleotide binding protein G protein 0.002 0.0012 0.0049
Onchocerca volvulus 0.0017 0.0005 0.0028
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0048 0.0068 0.0323
Brugia malayi conserved hypotetical protein 0.0043 0.0058 0.0302
Echinococcus granulosus histone lysine methyltransferase setb 0.012 0.0215 0.1033
Mycobacterium leprae conserved hypothetical protein 0.0215 0.0409 0.12
Echinococcus granulosus guanine nucleotide binding protein G protein 0.002 0.0012 0.0049
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0471 0.0931 0.4846
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0003 0.0015
Onchocerca volvulus Bile acid receptor homolog 0.0091 0.0156 0.0815
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0049 0.0258
Onchocerca volvulus 0.0135 0.0245 0.1286
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0029 0.0674
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0019 0.0038
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0127 0.306
Echinococcus granulosus acylamino acid releasing enzyme 0.0027 0.0025 0.0112
Brugia malayi MH1 domain containing protein 0.0026 0.0023 0.0119
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0071
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.002 0.0012 0.0063
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0002 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Brugia malayi nuclear receptor NHR-67 0.0043 0.0058 0.0302
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0027 0.0025 0.0017
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0126 0.06
Brugia malayi Nuclear hormone receptor E75 0.0043 0.0058 0.0302
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0025 0.0392
Onchocerca volvulus 0.0015 0.0002 0.001
Leishmania major hypothetical protein, conserved 0.0076 0.0127 0.3091
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.004 0.0116
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0023 0.0021
Brugia malayi nuclear receptor NHR-88 0.0043 0.0058 0.0302
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0004 0.0086
Loa Loa (eye worm) hypothetical protein 0.0091 0.0156 0.081
Loa Loa (eye worm) hypothetical protein 0.0076 0.0126 0.0654
Plasmodium falciparum importin beta, putative 0.0035 0.0042 0.3197
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0128 0.0231 0.1108
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0091 0.0156 0.081
Brugia malayi PHD-finger family protein 0.0029 0.0029 0.0153
Brugia malayi nuclear hormone receptor 0.0043 0.0058 0.0302
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0043 0.0058 0.0304
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0018 0.0446
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.012 0.0215 0.0213
Brugia malayi Nuclear hormone receptor E75 0.0043 0.0058 0.0302
Schistosoma mansoni RAR-like nuclear receptor 0.0091 0.0156 0.0917
Schistosoma mansoni ap endonuclease 0.0076 0.0125 0.0731
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0007 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0063
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0072 0.0118 0.0614
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0005 0.0021
Plasmodium vivax vivapain-2 0.0017 0.0005 0.0085
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0023 0.0125
Onchocerca volvulus 0.002 0.0012 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0215 0.0409 0.1247
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0028
Schistosoma mansoni gabp alpha 0.0077 0.0128 0.0751
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0065 0.0103 0.0102
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0302
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.0125 0.3011
Schistosoma mansoni retinoic acid receptor RXR 0.0091 0.0156 0.0917
Schistosoma mansoni DNA polymerase eta 0.0023 0.0018 0.0098
Onchocerca volvulus 0.0017 0.0005 0.0028
Onchocerca volvulus 0.0043 0.0058 0.0304
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0471 0.0931 0.4846
Mycobacterium tuberculosis Probable lipase LipD 0.0215 0.0409 0.1247
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0268 0.0516 0.2686
Echinococcus granulosus importin subunit beta 1 0.0035 0.0042 0.0193
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0215 0.0409 0.2429
Onchocerca volvulus 0.0017 0.0005 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0091 0.0156 0.081
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0215 0.0409 0.2131
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.002 0.0012 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0023 0.0562
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0126 0.0738
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.002 0.0012 0.0063
Loa Loa (eye worm) nuclear hormone receptor 0.0043 0.0058 0.0302
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.2497
Brugia malayi hypothetical protein 0.002 0.0012 0.0063
Echinococcus granulosus Nuclear hormone receptor HR96 0.0043 0.0058 0.0272
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.012 0.0215 0.0213
Mycobacterium leprae Probable lipase LipE 0.0215 0.0409 0.12
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0128 0.0231 0.1108
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0049 0.0769
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0092 0.0477
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0015 0.0002 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0005 0.0028
Onchocerca volvulus 0.0171 0.0319 0.1671
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0058 0.0056
Brugia malayi TAR-binding protein 0.0268 0.0516 0.2686
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0043 0.0058 0.0304
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0128 0.0231 0.12
Loa Loa (eye worm) hypothetical protein 0.0074 0.0122 0.0637
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.002 0.0012 0.0063
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0045
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0015 0.0002 0.0045
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0113 0.0201 0.0199
Brugia malayi Steroid receptor seven-up type 2 0.0091 0.0156 0.081
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0091 0.0156 0.0917
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.0125 0.0652
Brugia malayi beta-lactamase family protein 0.0215 0.0409 0.2131
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Schistosoma mansoni hypothetical protein 0.0128 0.0231 0.1363
Loa Loa (eye worm) hypothetical protein 0.0039 0.0051 0.0266
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0446
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0029 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0091 0.0156 0.081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Echinococcus multilocularis nuclear receptor nhr 48 0.0043 0.0058 0.0056
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0058 0.0272
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0023 0.0562
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.002 0.0012 0.001
Brugia malayi MH2 domain containing protein 0.0375 0.0734 0.3822
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0019 0.0038
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0076 0.0125 0.0648
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0215 0.0409 0.1247
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Echinococcus granulosus lysosomal alpha glucosidase 0.0173 0.0324 0.1561
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0005 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Echinococcus granulosus jumonji domain containing protein 0.004 0.0052 0.0244
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0015 0.0002 0.0045
Trichomonas vaginalis D-aminoacylase, putative 0.0215 0.0409 0.2144
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0025 0.0138
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0126 0.3037
Schistosoma mansoni hypothetical protein 0.0195 0.0369 0.2186
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0091 0.0156 0.0745
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0018 0.0446
Schistosoma mansoni nuclear hormone receptor 0.0091 0.0156 0.0917
Brugia malayi Serine carboxypeptidase S28 family protein 0.0039 0.0051 0.0266
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0173 0.0324 0.1687
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0091 0.0156 0.0745
Echinococcus multilocularis beta LACTamase domain containing family member 0.0215 0.0409 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Echinococcus multilocularis snurportin 1 0.0372 0.0728 0.0726
Echinococcus granulosus lamin dm0 0.0135 0.0245 0.118
Brugia malayi ecdysteroid receptor 0.0091 0.0156 0.081
Plasmodium falciparum phd finger protein, putative 0.0029 0.0029 0.2202
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0021 0.0019
Brugia malayi hypothetical protein 0.0048 0.0068 0.0356
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0043 0.0058 0.0056
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0102 0.2497
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0002 0.001
Trypanosoma brucei unspecified product 0.0016 0.0004 0.0086
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0014 0.0332
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0302
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0015 0.0002 0.001
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0043 0.0058 0.0302
Brugia malayi Cytochrome P450 family protein 0.0048 0.0068 0.0353
Onchocerca volvulus 0.0024 0.0019 0.0102
Entamoeba histolytica hypothetical protein 0.0028 0.0028 0.0442
Schistosoma mansoni hypothetical protein 0.0276 0.0532 0.3159
Loa Loa (eye worm) hypothetical protein 0.0958 0.1921 1
Brugia malayi ecdysone receptor 0.0043 0.0058 0.0302
Brugia malayi prolyl oligopeptidase family protein 0.0336 0.0655 0.3411
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0091 0.0156 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0091 0.0156 0.081
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0015 0.0002 0.0045
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0076 0.0125 0.3043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0471 0.0931 0.4502
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0113 0.0201 0.4908
Mycobacterium ulcerans AcrR family transcriptional regulator 0.162 0.327 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0003 0.0071
Entamoeba histolytica hypothetical protein 0.0329 0.064 1
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.002 0.0012 0.0063
Brugia malayi nuclear hormone receptor family member nhr-6 0.0043 0.0058 0.0302
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0028
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0048 0.113
Loa Loa (eye worm) DR-78 0.0043 0.0058 0.0302
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.002 0.0012 0.0061
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0074 0.0122 0.0718
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0091 0.0156 0.081
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0126 0.3037
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0018 0.0034
Brugia malayi nuclear receptor RXR 0.0048 0.0068 0.0356
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0028 0.0148
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.001
Echinococcus multilocularis lamin dm0 0.0135 0.0245 0.0244
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0019 0.0054
Loa Loa (eye worm) G protein alpha subunit 3 0.002 0.0012 0.0063
Entamoeba histolytica hypothetical protein 0.0329 0.064 1
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0042 0.0193
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0039 0.0051 0.1207
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0037
Trypanosoma brucei oligopeptidase b 0.0027 0.0025 0.0612
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0066 0.0105 0.0547
Echinococcus granulosus dna polymerase eta 0.0023 0.0018 0.008
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0015 0.0002 0.001
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.012 0.0215 0.5233
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0336 0.0655 0.3432
Brugia malayi Serine protease Z688.6 precursor 0.0039 0.0051 0.0266
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0076 0.0125 0.3043
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.002 0.0012 0.0061
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0215 0.0409 0.2429
Echinococcus granulosus tumor protein p63 0.1029 0.2066 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0005 0.0003
Schistosoma mansoni ap endonuclease 0.0076 0.0125 0.0731
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0049 0.0258
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0007 0.0173
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0049 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0091 0.0156 0.081
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0049 0.0258
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0018 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0004 0.0086
Echinococcus multilocularis smad 0.0026 0.0023 0.0021
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0027 0.0025 0.0612
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.002 0.0012 0.0063
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0039 0.0051 0.0267
Brugia malayi hypothetical protein 0.0086 0.0147 0.0763
Loa Loa (eye worm) ctsf protein 0.0017 0.0005 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0019 0.0101
Onchocerca volvulus 0.0151 0.0277 0.1453
Loa Loa (eye worm) hypothetical protein 0.012 0.0215 0.1119
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0003 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0068 0.0353
Mycobacterium tuberculosis Conserved protein 0.0215 0.0409 0.1247
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0018 0.0285
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0336 0.0655 0.3166
Echinococcus granulosus cathepsin l1 0.0017 0.0005 0.0017
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0042 0.0237
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0043 0.0058 0.0056
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0042 0.0978
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0025 0.057
Schistosoma mansoni tar DNA-binding protein 0.0268 0.0516 0.3065
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.002 0.0012 0.0063
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0019 0.0101
Brugia malayi follicle stimulating hormone receptor 0.0694 0.1384 0.7203
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0172
Loa Loa (eye worm) hypothetical protein 0.0049 0.0071 0.037
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0007 0.0173
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0027 0.0025 0.0055
Schistosoma mansoni hypothetical protein 0.0839 0.168 1
Echinococcus granulosus dna polymerase kappa 0.0023 0.0018 0.008
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0113 0.0201 0.1187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0126 0.0124
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0074 0.0122 0.0584
Toxoplasma gondii cathepsin CPL 0.0017 0.0005 0.0085
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0048 0.117
Schistosoma mansoni nuclear receptor nhr-48 0.0043 0.0058 0.0335
Plasmodium vivax hypothetical protein, conserved 0.0215 0.0409 1
Entamoeba histolytica hypothetical protein 0.0329 0.064 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0023 0.0519
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0041 0.0188
Brugia malayi RNA binding protein 0.0268 0.0516 0.2686
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0028
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0091 0.0156 0.0154
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0733 0.1464 0.7084
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0007 0.0172
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0023 0.012
Loa Loa (eye worm) hypothetical protein 0.0048 0.0068 0.0356
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0471 0.0931 0.4502
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0019 0.0303
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0039 0.0051 0.0798
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0025 0.013
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0329 0.064 0.3091
Loa Loa (eye worm) hypothetical protein 0.0215 0.0409 0.2131
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0074 0.0122 0.9822
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0021 0.0502
Mycobacterium ulcerans transcriptional regulator 0.162 0.327 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0043 0.0058 0.0272
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0045
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1376 0.2773 0.8477
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0042 0.0237
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0063
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.002 0.0012 0.001
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0126 0.0327
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.002 0.0012 0.0063
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0048 0.0068 0.0397
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0129
Leishmania major cathepsin L-like protease 0.0065 0.0102 0.2497
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0015 0.0002 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Echinococcus multilocularis musashi 0.0135 0.0245 0.0244
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0049 0.0256
Entamoeba histolytica hypothetical protein 0.0329 0.064 1
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0007 0.0422
Schistosoma mansoni transcription factor LCR-F1 0.0329 0.064 0.3803
Loa Loa (eye worm) hypothetical protein 0.0151 0.0277 0.1444
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.001
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0003 0.0071
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0048 0.3787
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.002 0.0012 0.0061
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0003 0.0026
Onchocerca volvulus 0.0015 0.0002 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Giardia lamblia Alanyl dipeptidyl peptidase 0.0027 0.0025 0.1892
Trichomonas vaginalis set domain proteins, putative 0.0952 0.1909 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0018 0.0446
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.013
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0091 0.0156 0.081
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0072 0.0216
Onchocerca volvulus 0.002 0.0012 0.0063
Echinococcus multilocularis peregrin 0.0032 0.0036 0.0035
Brugia malayi Fli-1 protein 0.0234 0.0448 0.233
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0058 0.0335
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0005 0.0003
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0023 0.0119
Loa Loa (eye worm) hypothetical protein 0.0215 0.0409 0.2131
Toxoplasma gondii exonuclease III APE 0.0076 0.0125 0.3011
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.002 0.0012 0.0063
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0024 0.0015
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0018 0.0446
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0446
Echinococcus granulosus peregrin 0.0032 0.0036 0.0167
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0049 0.0258
Echinococcus granulosus lamin 0.0135 0.0245 0.118
Leishmania major endonuclease/exonuclease protein-like protein 0.0015 0.0002 0.0045
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.0125 0.984
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0128 0.0231 0.0229
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0129
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0003 0.0085
Brugia malayi CCR4 0.0015 0.0002 0.001
Brugia malayi Nuclear hormone receptor-like 1 0.0091 0.0156 0.081
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0025 0.0392
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0446
Mycobacterium tuberculosis Probable lipase LipE 0.0215 0.0409 0.1247
Loa Loa (eye worm) MH2 domain-containing protein 0.0375 0.0734 0.3822
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0215 0.0409 0.1233
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0126 0.3037
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0095
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0215 0.0409 0.1247
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0258 0.1345
Schistosoma mansoni hypothetical protein 0.0128 0.0231 0.1363
Echinococcus multilocularis survival motor neuron protein 1 0.0958 0.1921 0.192
Onchocerca volvulus 0.002 0.0012 0.0063
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0127 0.3091
Loa Loa (eye worm) fli-1 protein 0.0234 0.0448 0.233
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0403 0.0792 0.4121
Onchocerca volvulus 0.01 0.0175 0.0917
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0039 0.0051 0.0798
Echinococcus multilocularis GPCR, family 2 0.0128 0.0231 0.0229
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0003 0.0026
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0016 0.0004 0.0093
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0127 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0173 0.0324 0.1687
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0027 0.0025 0.0131
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0005 0.0028
Echinococcus granulosus geminin 0.0839 0.168 0.8129
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0007 0.011
Loa Loa (eye worm) hypothetical protein 0.0132 0.024 0.1251
Loa Loa (eye worm) RNA binding protein 0.0268 0.0516 0.2686
Schistosoma mansoni tar DNA-binding protein 0.0268 0.0516 0.3065
Loa Loa (eye worm) hypothetical protein 0.0403 0.0792 0.4121
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0329 0.064 0.0638
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0018 0.0446
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0018 0.0016
Schistosoma mansoni thyroid hormone receptor 0.0091 0.0156 0.0917
Echinococcus granulosus Dipeptidyl peptidase 9 0.0113 0.0201 0.0965
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0074 0.0122 0.0641
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0091 0.0156 0.0917
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0007 0.0127
Loa Loa (eye worm) hypothetical protein 0.0215 0.0409 0.2131
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0129
Loa Loa (eye worm) hypothetical protein 0.0091 0.0156 0.081
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0048 0.0748
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0446
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0005 0.001
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0002 0.0029
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0039 0.0051 0.0267
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0694 0.1384 0.7203
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0025 0.0138
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.002 0.0012 0.0063
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0042 0.1019
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0302
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0003 0.0026
Schistosoma mansoni ran 0.0026 0.0023 0.0126
Onchocerca volvulus 0.0215 0.0409 0.2144
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0039 0.0051 0.0293
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0215 0.1271
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0091 0.0156 0.081
Schistosoma mansoni steroid hormone receptor ad4bp 0.0091 0.0156 0.0917
Brugia malayi Bromodomain containing protein 0.0032 0.0036 0.0189
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0052 0.005
Leishmania major hypothetical protein, conserved 0.0015 0.0002 0.0045
Loa Loa (eye worm) hypothetical protein 0.0215 0.0409 0.2131
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0028
Brugia malayi hypothetical protein 0.0076 0.0127 0.0659
Onchocerca volvulus 0.0017 0.0005 0.0028
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0091 0.0156 0.081
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0018 0.0016
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0055 0.1313
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0023 0.1696
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0048 0.0068 0.0397
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0446
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0074 0.181
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0045
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.162 0.327 1
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0027 0.0025 0.0612
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0074 0.0122 0.0641
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0025 0.013
Giardia lamblia PHD finger protein 15 0.0029 0.0029 0.2238
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0029 0.0153
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0005 0.0129
Brugia malayi latrophilin 2 splice variant baaae 0.0276 0.0532 0.2769
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0091 0.2218
Trypanosoma brucei hypothetical protein, conserved 0.0215 0.0409 1
Trypanosoma cruzi hypothetical protein, conserved 0.0215 0.0409 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Trypanosoma cruzi oligopeptidase b 0.0027 0.0025 0.0612
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0048 0.0068 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0049 0.0256
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0102 0.2497
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0018 0.0098
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0023 0.0562
Loa Loa (eye worm) hypothetical protein 0.0091 0.0156 0.081
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0002 0.001
Leishmania major cathepsin L-like protease 0.0065 0.0102 0.2497
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0019 0.0038
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0019 0.0038
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0049 0.0258
Trypanosoma brucei RNA editing exonuclease 2 0.0015 0.0002 0.0045
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0048 0.117
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0129
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0049 0.0258
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0172
Onchocerca volvulus 0.0039 0.0051 0.0267
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0049 0.1202
Onchocerca volvulus 0.0091 0.0156 0.0815
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0005 0.0028
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0007 0.0172
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0005 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0028
Mycobacterium ulcerans beta-lactamase 0.0215 0.0409 0.1233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.001
Echinococcus multilocularis expressed protein 0.002 0.0012 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0127 0.306
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0027 0.0025 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0021 0.0108
Schistosoma mansoni GTP-binding protein alpha subunit 0.002 0.0012 0.0061
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0005 0.0028
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0055 0.029
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Loa Loa (eye worm) nuclear receptor NHR-67 0.0043 0.0058 0.0302
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0018 0.0446
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0091 0.0156 0.0745
Trypanosoma cruzi mitochondrial protein 99, putative 0.0015 0.0002 0.0045
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0005
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0018 0.0095
Loa Loa (eye worm) hypothetical protein 0.0048 0.0068 0.0356
Echinococcus multilocularis cysteine protease 0.0017 0.0005 0.0003
Echinococcus multilocularis cysteine protease 0.0017 0.0005 0.0003
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0048 0.117
Onchocerca volvulus 0.0952 0.1909 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0091 0.0156 0.081
Echinococcus granulosus FTZ F1 alpha 0.0091 0.0156 0.0745
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0025 0.0612
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0055 0.029
Giardia lamblia Alanyl dipeptidyl peptidase 0.0027 0.0025 0.1892
Mycobacterium ulcerans TetR family transcriptional regulator 0.162 0.327 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Loa Loa (eye worm) hypothetical protein 0.0091 0.0156 0.081
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0019 0.0474
Brugia malayi jmjC domain containing protein 0.0094 0.0162 0.0845
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0091 0.0156 0.081
Schistosoma mansoni hypothetical protein 0.0029 0.0029 0.0164
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.002 0.0012 0.0049
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0258 0.0257
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0005 0.0028
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0302
Schistosoma mansoni hypothetical protein 0.0372 0.0728 0.4327
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0007 0.0172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0028
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0018 0.0446
Loa Loa (eye worm) hypothetical protein 0.0091 0.0156 0.081
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0004 0.0086
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0007 0.0172
Echinococcus multilocularis tar DNA binding protein 0.0268 0.0516 0.0514
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0007 0.0172
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0025 0.0392
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0045
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0015 0.0002 0.0029
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0126 1
Echinococcus granulosus ecdysone induced protein 78C 0.0091 0.0156 0.0745
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0126 0.0363
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0028 0.0148
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0023 0.0021
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0049 0.0258
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0127 0.3091
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.002 0.0012 0.0061
Brugia malayi Calcitonin receptor-like protein seb-1 0.0403 0.0792 0.4121
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.002 0.0012 0.0061
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0003 0.0071
Brugia malayi Pre-SET motif family protein 0.0836 0.1674 0.8712
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0029 0.0674
Loa Loa (eye worm) cysteine protease 0.0017 0.0005 0.0028
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0091 0.0156 0.0917
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0001
Brugia malayi prolyl oligopeptidase family protein 0.0113 0.0201 0.1046
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0028 0.0691
Onchocerca volvulus 0.0019 0.0009 0.0048
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0007 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Trichomonas vaginalis D-aminoacylase, putative 0.0215 0.0409 0.2144
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0113 0.0201 0.4908
Trypanosoma brucei prolyl oligopeptidase, putative 0.0027 0.0025 0.0612
Echinococcus multilocularis ecdysone induced protein 78C 0.0091 0.0156 0.0154
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.002 0.0012 0.0063
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0028
Loa Loa (eye worm) hypothetical protein 0.0024 0.0019 0.0101
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0302
Giardia lamblia GTOR 0.0018 0.0007 0.0423
Schistosoma mansoni nuclear receptor 0.0043 0.0058 0.0335
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0015 0.0002 0.0045
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0021 0.0107
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0126 1
Onchocerca volvulus 0.0195 0.0369 0.1931
Brugia malayi hypothetical protein 0.0048 0.0068 0.0356
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0043 0.0058 0.0302
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.001
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.002 0.0012 0.0063
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0126 0.9926
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0023 0.0119
Mycobacterium tuberculosis Conserved protein 0.0215 0.0409 0.1247
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.0125 0.0652
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0018 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0007 0.0016
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0002 0.0029
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.002 0.0012 0.0061
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0028
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0023 0.1723
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0027 0.0025 0.0612
Brugia malayi Intermediate filament tail domain containing protein 0.0135 0.0245 0.1277
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0058 0.0335
Loa Loa (eye worm) hypothetical protein 0.0065 0.0103 0.0538
Loa Loa (eye worm) hypothetical protein 0.0063 0.0098 0.0512
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0074 0.0122 0.1912
Loa Loa (eye worm) hypothetical protein 0.0063 0.0098 0.0512
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0027 0.0025 0.0138
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0002 0.001
Toxoplasma gondii ABC1 family protein 0.0215 0.0409 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0021 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0091 0.0156 0.0917
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0005 0.0021
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0113 0.0201 0.4885
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0005 0.0017
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0005 0.0017
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.001
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0043 0.0058 0.0056
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0019 0.0303
Loa Loa (eye worm) hypothetical protein 0.0135 0.0245 0.1277
Loa Loa (eye worm) intermediate filament protein 0.0135 0.0245 0.1277
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0018 0.0446
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0471 0.0931 0.5538
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0007 0.0037
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0041 0.0039
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0126 1
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0042 0.004
Brugia malayi Nuclear hormone receptor-like 1 0.0048 0.0068 0.0356
Mycobacterium ulcerans esterase/lipase LipP 0.0215 0.0409 0.1233
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0002 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.012 0.0215 0.1271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Loa Loa (eye worm) hypothetical protein 0.0048 0.0068 0.0356
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0076 0.0125 0.0123
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0091 0.0156 0.0917
Schistosoma mansoni zinc finger protein 0.0043 0.0058 0.0335
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0072 0.0216
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0135 0.0245 0.1277
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0005 0.0129
Onchocerca volvulus Huntingtin homolog 0.0121 0.0216 0.1132
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0302
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Leishmania major DNA polymerase eta, putative 0.0023 0.0018 0.0446
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0015 0.0002 0.0029
Echinococcus multilocularis GA binding protein alpha chain 0.0077 0.0128 0.0126
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0042 0.1019
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0055 0.1313
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0076 0.0125 0.0375
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0091 0.0156 0.081
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0063
Brugia malayi Ets-domain containing protein 0.0077 0.0128 0.0665
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0019 0.0474
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0015 0.0002 0.001
Brugia malayi hypothetical protein 0.0049 0.0071 0.0371
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0015 0.0002 0.001
Loa Loa (eye worm) prolyl oligopeptidase 0.0336 0.0655 0.3411
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0007 0.0031
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0049 0.0047
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0015 0.0002 0.0045
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0025 0.0392
Loa Loa (eye worm) hypothetical protein 0.0091 0.0156 0.081
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0336 0.0655 0.0654
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0072 0.007
Brugia malayi MH2 domain containing protein 0.0026 0.0023 0.0119
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0023 0.0102
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0471 0.0931 0.0929
Mycobacterium tuberculosis Probable esterase LipL 0.0215 0.0409 0.1247
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0029 0.0674
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0028
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0007 0.0172
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0128 0.0231 0.0229
Loa Loa (eye worm) hypothetical protein 0.0121 0.0216 0.1125
Loa Loa (eye worm) hypothetical protein 0.0048 0.0068 0.0356
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0836 0.1674 0.8712
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.2497
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.001
Loa Loa (eye worm) prolyl oligopeptidase 0.0027 0.0025 0.013
Trypanosoma brucei unspecified product 0.0023 0.0018 0.0446
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.013
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0002 0.0029
Echinococcus granulosus Smad4 0.0026 0.0023 0.0102
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0065 0.0103 0.0492
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0091 0.0156 0.0917
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0733 0.1464 0.8714
Onchocerca volvulus Huntingtin homolog 0.0121 0.0216 0.1132
Schistosoma mansoni nuclear receptor 0.0043 0.0058 0.0335
Schistosoma mansoni smad1 5 8 and 0.0026 0.0023 0.0125
Mycobacterium tuberculosis Probable peptidase 0.0027 0.0025 0.0071
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0049 0.0769
Echinococcus granulosus guanine nucleotide binding protein subunit 0.002 0.0012 0.0049
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0018 0.0095
Brugia malayi Nuclear hormone receptor-like 1 0.0048 0.0068 0.0356
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0055 0.1313
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0039 0.0051 0.1247
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0037
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0007 0.0025
Plasmodium vivax vivapain-2 0.0017 0.0005 0.0085
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.001
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0019 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0091 0.0156 0.081
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.002 0.0012 0.0063
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0027 0.0025 0.0131
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0048 0.0755
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0028
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0003 0.0001
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0127 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0002 0.001
Leishmania major hypothetical protein, conserved 0.0015 0.0002 0.0045
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.0122 0.2989
Onchocerca volvulus Alhambra homolog 0.0029 0.0029 0.0153
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.002 0.0012 0.001
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.001
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.002 0.0012 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Echinococcus multilocularis FTZ F1 alpha 0.0091 0.0156 0.0154
Toxoplasma gondii hypothetical protein 0.0027 0.0025 0.057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0215 0.1271
Trichomonas vaginalis penicillin-binding protein, putative 0.0215 0.0409 0.2144
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0051 0.0267
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0015 0.0002 0.0045
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0029 0.0027
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0116 0.0206 0.099
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0025 0.0131
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0021 0.0459
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0028
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0072 0.0341
Plasmodium vivax SET domain protein, putative 0.012 0.0215 0.5233
Schistosoma mansoni inositol monophosphatase 0.0038 0.0048 0.0274
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0195 0.0369 0.1919
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0005 0.0277
Brugia malayi RNA, U transporter 1 0.0099 0.0172 0.0898
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0029 0.0164
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0049 0.0258
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0025 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0113 0.0201 0.4908
Brugia malayi beta-lactamase family protein 0.0215 0.0409 0.2131
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0023 0.012
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0076 0.0125 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0302
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0258 0.1529
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0039 0.0051 0.0238
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0015 0.0002 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0446
Schistosoma mansoni GTP-binding protein alpha subunit 0.002 0.0012 0.0061
Treponema pallidum exodeoxyribonuclease (exoA) 0.0076 0.0125 0.9913
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0091 0.0156 0.081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0028
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0471 0.0931 0.0929
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0015 0.0002 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0446
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0091 0.0156 0.0154
Trypanosoma cruzi oligopeptidase b 0.0027 0.0025 0.0612
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0215 0.0409 0.2131
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0048 0.0251
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0039 0.0051 0.0267
Onchocerca volvulus 0.0043 0.0058 0.0304
Loa Loa (eye worm) inositol-1 0.0038 0.0048 0.0249
Onchocerca volvulus 0.0017 0.0005 0.0028
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0007 0.0031
Leishmania major hypothetical protein, conserved 0.0215 0.0409 1
Schistosoma mansoni survival motor neuron protein 0.0195 0.0369 0.2186
Onchocerca volvulus 0.0017 0.0005 0.0028
Loa Loa (eye worm) Smad1 0.0026 0.0023 0.0119
Brugia malayi orphan nuclear receptor NR2E1 0.0043 0.0058 0.0302
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0049 0.1202
Schistosoma mansoni smad1 5 8 and 0.0026 0.0023 0.0125
Schistosoma mansoni ran 0.0026 0.0023 0.0126
Loa Loa (eye worm) hypothetical protein 0.0215 0.0409 0.2131
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0002 0.001
Schistosoma mansoni hypothetical protein 0.0329 0.064 0.3803
Schistosoma mansoni smad 0.0026 0.0023 0.0125
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0007 0.011
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.0324 0.0322
Trypanosoma cruzi prolyl endopeptidase 0.0027 0.0025 0.0612
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0021 0.0112
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0001
Brugia malayi MH2 domain containing protein 0.0026 0.0023 0.0119
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0074 0.0122 0.2989
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.0215 0.0409 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0048 0.0068 0.0356
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0049 0.1162
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0091 0.0156 0.0815
Schistosoma mansoni hypothetical protein 0.0128 0.0231 0.1363
Trypanosoma brucei prolyl endopeptidase 0.0027 0.0025 0.0612
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0045
Schistosoma mansoni tar DNA-binding protein 0.0268 0.0516 0.3065
Onchocerca volvulus 0.012 0.0215 0.1127
Brugia malayi Pre-SET motif family protein 0.012 0.0215 0.1119
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0027 0.0025 0.0612
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0007 0.0037
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0023 0.0102
Schistosoma mansoni smad1 5 8 and 0.0026 0.0023 0.0125
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0001
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0028 0.0148
Brugia malayi nuclear receptor NHR-88 0.0091 0.0156 0.081
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0063
Schistosoma mansoni trimeric G-protein alpha o subunit 0.002 0.0012 0.0061
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0039 0.0051 0.1247
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0076 0.0125 0.1947
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0113 0.0201 0.4908
Echinococcus granulosus intermediate filament protein 0.0135 0.0245 0.118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.2497
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0302
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0446
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0018 0.008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.2497
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0091 0.0156 0.0745
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0471 0.0931 0.5538
Echinococcus multilocularis Smad4 0.0026 0.0023 0.0021
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0002 0.001
Brugia malayi tailless protein 0.0043 0.0058 0.0302
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0018 0.0446
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0025 0.013
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0091 0.0156 0.0154
Echinococcus multilocularis thyroid hormone receptor alpha 0.0091 0.0156 0.0154
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0007 0.0037
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0027 0.0025 0.057
Leishmania major oligopeptidase b 0.0027 0.0025 0.0612
Loa Loa (eye worm) acetyltransferase 0.0141 0.0258 0.1345
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0049 0.1202
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Loa Loa (eye worm) hypothetical protein 0.0024 0.0019 0.0101
Brugia malayi G-protein alpha subunit 0.002 0.0012 0.0063
Entamoeba histolytica Ran family GTPase 0.0026 0.0023 0.0359
Giardia lamblia Thymus-specific serine protease precursor 0.0039 0.0051 0.4009
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Schistosoma mansoni inositol monophosphatase 0.0038 0.0048 0.0274
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.001
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0005 0.0277
Plasmodium falciparum peptidase, putative 0.0027 0.0025 0.1861
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0007 0.0129
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0042 0.004
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0018 0.0034
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0002 0.0029
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0076 0.0125 0.3043
Echinococcus granulosus GA binding protein alpha chain 0.0077 0.0128 0.061
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0015 0.0002 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.2497
Giardia lamblia Serine peptidase, putative 0.0039 0.0051 0.4009
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0074 0.0122 0.0584
Schistosoma mansoni hypothetical protein 0.0128 0.0231 0.1363
Echinococcus granulosus microtubule associated protein 2 0.0697 0.139 0.6724
Echinococcus granulosus Nuclear hormone receptor HR96 0.0043 0.0058 0.0272
Loa Loa (eye worm) beta-lactamase 0.0215 0.0409 0.2131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0027 0.0025 0.0071
Brugia malayi hypothetical protein 0.0043 0.0058 0.0302
Brugia malayi nuclear receptor RXR 0.0043 0.0058 0.0302
Leishmania major importin beta-1 subunit, putative 0.0028 0.0028 0.0691
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0018 0.0095
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0126 1
Onchocerca volvulus 0.0215 0.0409 0.2144
Onchocerca volvulus 0.0017 0.0005 0.0028
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0007 0.0172
Brugia malayi photoreceptor-specific nuclear receptor 0.0091 0.0156 0.081
Trypanosoma brucei unspecified product 0.0016 0.0004 0.0086
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0055 0.0259
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0005 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0005 0.001
Schistosoma mansoni lamin 0.0135 0.0245 0.1452
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0074 0.0122 0.0121
Brugia malayi MH1 domain containing protein 0.0026 0.0023 0.0119
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0048 0.117
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0051 0.0267
Onchocerca volvulus 0.0135 0.0245 0.1286
Echinococcus granulosus thyroid hormone receptor alpha 0.0043 0.0058 0.0272
Plasmodium vivax importin-beta 2, putative 0.0035 0.0042 0.0978
Leishmania major hypothetical protein, conserved 0.0015 0.0002 0.0045
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0002 0.0045
Trypanosoma cruzi mitochondrial protein 99, putative 0.0015 0.0002 0.0045
Leishmania major DNA polymerase kappa, putative 0.0023 0.0018 0.0446
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0023 0.0102
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.002 0.0012 0.0061
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0007 0.0172
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0048 0.3726
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0019 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Loa Loa (eye worm) hypothetical protein 0.0171 0.0319 0.166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.2497
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0043 0.0058 0.0335
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.162 0.327 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0091 0.0156 0.0745
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0043 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0039 0.0051 0.0266
Schistosoma mansoni alpha glucosidase 0.0038 0.0049 0.0282
Leishmania major pantothenate kinase subunit, putative 0.0016 0.0004 0.0093
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0024 0.0547
Onchocerca volvulus 0.0215 0.0409 0.2144
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0005 0.0003
Toxoplasma gondii prolyl endopeptidase 0.0027 0.0025 0.057
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0076 0.0125 0.9862
Schistosoma mansoni ets-related 0.0234 0.0448 0.2657
Brugia malayi Latrophilin receptor protein 2 0.0128 0.0231 0.12
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0019 0.0303
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0015 0.0002 0.0045
Trichomonas vaginalis D-aminoacylase, putative 0.0215 0.0409 0.2144
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0027 0.0025 0.0612
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0091 0.0156 0.081
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0015 0.0002 0.0045
Brugia malayi hypothetical protein 0.0121 0.0216 0.1125
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0019 0.0038
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0003 0.0071
Brugia malayi isocitrate dehydrogenase 0.0016 0.0003 0.0015
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0003 0.0015
Brugia malayi steroid hormone receptor 0.0091 0.0156 0.081
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0018 0.0446
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0002 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0215 0.1271
Echinococcus multilocularis ubiquitin specific protease 41 0.0074 0.0122 0.0121
Mycobacterium ulcerans lipase LipD 0.0215 0.0409 0.1233
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0005 0.0277
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0091 0.0156 0.0745
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0076 0.0125 0.3043
Schistosoma mansoni Smad4 0.0026 0.0023 0.0125
Brugia malayi hypothetical protein 0.0043 0.0058 0.0302
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0126 0.0363
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0091 0.0156 0.081
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.0122 0.2989
Echinococcus granulosus tar DNA binding protein 0.0268 0.0516 0.2492
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0018 0.0096
Schistosoma mansoni tar DNA-binding protein 0.0268 0.0516 0.3065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0063
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0733 0.1464 0.1462
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0091 0.0156 0.081
Brugia malayi Ets-domain containing protein 0.0077 0.0128 0.0665
Onchocerca volvulus Protein ultraspiracle homolog 0.0091 0.0156 0.0815
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.002 0.0012 0.0063
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0015 0.0002 0.0029
Mycobacterium ulcerans hypothetical protein 0.0215 0.0409 0.1233
Toxoplasma gondii hypothetical protein 0.0026 0.0024 0.0547
Brugia malayi Importin beta-1 subunit 0.0035 0.0042 0.0217
Trichomonas vaginalis penicillin-binding protein, putative 0.0215 0.0409 0.2144
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0403 0.0792 0.4121
Leishmania major cathepsin L-like protease 0.0065 0.0102 0.2497
Brugia malayi beta-lactamase 0.0215 0.0409 0.2131
Brugia malayi hypothetical protein 0.0958 0.1921 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.001
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0172
Mycobacterium tuberculosis Conserved protein 0.0215 0.0409 0.1247
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0302
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0015 0.0002 0.001
Schistosoma mansoni hypothetical protein 0.0034 0.0041 0.0231
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0172
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.002 0.0012 0.0061
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0005 0.001
Echinococcus granulosus smad 0.0026 0.0023 0.0102
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0127 0.3091
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.025 0.1204
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0302
Echinococcus multilocularis lamin 0.0135 0.0245 0.0244
Echinococcus granulosus GPCR family 2 0.0128 0.0231 0.1108
Trypanosoma brucei glucosidase, putative 0.0038 0.0049 0.1202
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0021 0.0091
Echinococcus multilocularis tumor protein p63 0.1029 0.2066 0.2064
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0091 0.0156 0.081
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.002 0.0012 0.0061
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0003 0.0006
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0025 0.0392
Brugia malayi exodeoxyribonuclease III family protein 0.0076 0.0125 0.0648
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0162 0.0778
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.002 0.0012 0.0063
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0007 0.0025
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0028
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0002 0.0045
Loa Loa (eye worm) hypothetical protein 0.0024 0.0019 0.0101
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0005 0.0083
Schistosoma mansoni microtubule-associated protein tau 0.0697 0.139 0.8271
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0005 0.0028
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.002 0.0012 0.0061
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0091 0.0156 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0091 0.0156 0.0745
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.002 0.0012 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.2497
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0003 0.0071
Schistosoma mansoni alpha-glucosidase 0.0149 0.0275 0.1627
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.2497
Mycobacterium ulcerans hypothetical protein 0.0024 0.0019 0.0038
Loa Loa (eye worm) TAR-binding protein 0.0268 0.0516 0.2686
Loa Loa (eye worm) hypothetical protein 0.0121 0.0216 0.1125
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0005 0.0028
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0048 0.0046
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0048 0.0251
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0728 0.3788
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0037
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0007 0.0172
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0102 0.2497
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0028
Trichomonas vaginalis ran, putative 0.0026 0.0023 0.012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.2497
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.002 0.0012 0.0063
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0007 0.0005
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0039 0.0051 0.0049
Echinococcus granulosus guanine nucleotide binding protein subunit 0.002 0.0012 0.0049
Echinococcus multilocularis dna polymerase eta 0.0023 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0215 0.0409 0.2131
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0045
Mycobacterium tuberculosis Probable hydrolase 0.0215 0.0409 0.1247
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0162 0.0161
Brugia malayi Serine protease Z688.6 precursor 0.0039 0.0051 0.0266
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0039 0.0051 0.1247
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0471 0.0931 0.5538
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0076 0.0125 0.0595
Loa Loa (eye worm) transcription factor SMAD2 0.0375 0.0734 0.3822
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.2497
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Trichomonas vaginalis Phospholipase C precursor, putative 0.0015 0.0002 0.001
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.002 0.0012 0.0063
Echinococcus granulosus ubiquitin specific protease 41 0.0074 0.0122 0.0584
Loa Loa (eye worm) hypothetical protein 0.0076 0.0127 0.0659
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0091 0.0156 0.0154
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0019 0.0101
Loa Loa (eye worm) hypothetical protein 0.0039 0.0051 0.0266
Leishmania major GTP-binding protein, putative 0.0026 0.0023 0.0562
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0048 0.0251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0005 0.0083
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0113 0.0201 0.4908
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.004 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0091 0.0156 0.081
Entamoeba histolytica G protein alpha subunit, putative 0.002 0.0012 0.0188
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0049 0.0258
Echinococcus granulosus beta LACTamase domain containing family member 0.0215 0.0409 0.1974
Loa Loa (eye worm) hypothetical protein 0.0086 0.0147 0.0763
Onchocerca volvulus Putative neutral sphingomyelinase 0.0015 0.0002 0.001
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0076 0.0125 0.036
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0074 0.0122 0.0121
Trichomonas vaginalis esterase, putative 0.0215 0.0409 0.2144
Echinococcus multilocularis geminin 0.0839 0.168 0.1678
Loa Loa (eye worm) hypothetical protein 0.0091 0.0156 0.081
Schistosoma mansoni hypothetical protein 0.0839 0.168 1
Entamoeba histolytica hypothetical protein 0.0024 0.0021 0.0321
Echinococcus granulosus snurportin 1 0.0372 0.0728 0.3517
Echinococcus granulosus expressed protein 0.002 0.0012 0.0049
Echinococcus multilocularis prolyl endopeptidase 0.0027 0.0025 0.0023
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0024 0.1788
Loa Loa (eye worm) hypothetical protein 0.0048 0.0068 0.0356
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0077 0.0128 0.0665
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0023 0.0519
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0091 0.0156 0.081
Loa Loa (eye worm) latrophilin receptor protein 2 0.0128 0.0231 0.12
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0074 0.0122 0.0718
Loa Loa (eye worm) hypothetical protein 0.0091 0.0156 0.081
Schistosoma mansoni tar DNA-binding protein 0.0268 0.0516 0.3065
Brugia malayi nuclear hormone receptor family member odr-7 0.0043 0.0058 0.0302
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0336 0.0655 0.3895
Brugia malayi cytoplasmic intermediate filament protein 0.0072 0.0118 0.0614

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8275 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.1995 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 10.3183 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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