Detailed information for compound 1313120

Basic information

Technical information
  • TDR Targets ID: 1313120
  • Name: N-[2-(4-chlorophenyl)ethyl]-2-[[(2-fluorophen yl)methyl-(phenylmethyl)carbamothioyl]amino]a cetamide
  • MW: 470.002 | Formula: C25H25ClFN3OS
  • H donors: 1 H acceptors: 1 LogP: 5.6 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN=C(N(Cc1ccccc1F)Cc1ccccc1)S)NCCc1ccc(cc1)Cl
  • InChi: 1S/C25H25ClFN3OS/c26-22-12-10-19(11-13-22)14-15-28-24(31)16-29-25(32)30(17-20-6-2-1-3-7-20)18-21-8-4-5-9-23(21)27/h1-13H,14-18H2,(H,28,31)(H,29,32)
  • InChiKey: JQLQKFSSOLSGNM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(4-chlorophenyl)ethyl]-2-[[[(2-fluorophenyl)methyl-(phenylmethyl)amino]-thioxomethyl]amino]acetamide
  • 2-[[benzyl-(2-fluorobenzyl)thiocarbamoyl]amino]-N-[2-(4-chlorophenyl)ethyl]acetamide
  • N-[2-(4-chlorophenyl)ethyl]-2-[[(2-fluorophenyl)methyl-(phenylmethyl)carbamothioyl]amino]ethanamide
  • SMR000311296
  • MLS000674018
  • N~2~-{[benzyl(2-fluorobenzyl)amino]carbonothioyl}-N~1~-[2-(4-chlorophenyl)ethyl]glycinamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 4 Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis esterase, putative 0.0071 0.0183 0.0864
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0118 0.0385
Echinococcus multilocularis cysteine protease 0.0016 0.0016 0.0016
Onchocerca volvulus 0.0016 0.0016 0.0074
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0268 0.1454
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0128 0.9112
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0205
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0024 0.1274
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0119 0.6485
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0038 0.018
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.0118 0.0385
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0197 0.0373
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0023 0.0038 0.0038
Brugia malayi Steroid receptor seven-up type 2 0.005 0.0118 0.0642
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0016 0.0732
Echinococcus multilocularis musashi 0.0135 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0205
Brugia malayi TAR-binding protein 0.0261 0.0764 0.4144
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0012 0.0001 0.0006
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0016 0.0051
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0141 0.7679
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0026 0.0046 0.0151
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0081 0.0437
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0001 0.0006
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0016 0.0074
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0024 0.0121
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0037 0.0075
Loa Loa (eye worm) hypothetical protein 0.0063 0.0157 0.0853
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0183 0.0595
Leishmania major cathepsin L-like protease 0.0062 0.0155 0.8468
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0024 0.0024
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0239 0.0696 0.0696
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0088 0.0235 0.0235
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0084 0.0084
Mycobacterium ulcerans lipase LipD 0.0071 0.0183 0.0343
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0023 0.0038 0.0188
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0197 1
Onchocerca volvulus 0.0023 0.0038 0.018
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0044
Onchocerca volvulus 0.0016 0.0016 0.0074
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0197 0.0981
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0141 0.0255
Brugia malayi mbt repeat family protein 0.0058 0.0142 0.0771
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0167 0.0542
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0024 0.0132
Schistosoma mansoni synaptojanin 0.0012 0.0001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0205
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0197 1
Toxoplasma gondii exonuclease III APE 0.0057 0.0141 0.5956
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0268 0.1454
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0084 0.4536
Plasmodium vivax vivapain-2 0.0016 0.0016 0.0613
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0068
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0084 0.0453
Schistosoma mansoni nuclear receptor 0.0023 0.0038 0.0188
Echinococcus multilocularis nuclear receptor nhr 48 0.0023 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0067 0.0173 0.0935
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0046 0.0018
Loa Loa (eye worm) hypothetical protein 0.0071 0.0183 0.0991
Schistosoma mansoni lamin 0.0135 0.0378 0.1881
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0068
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0118 0.0588
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.0118 0.0588
Brugia malayi follicle stimulating hormone receptor 0.0485 0.145 0.7859
Loa Loa (eye worm) DR-78 0.0023 0.0038 0.0205
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0042 0.021
Schistosoma mansoni alpha glucosidase 0.0037 0.0081 0.0401
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0183 0.0343
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0183 0.0864
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.0118 0.0642
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0016 0.0279
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0024 0.0024
Onchocerca volvulus 0.0012 0.0001 0.0006
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0042 0.0042
Onchocerca volvulus 0.0058 0.0142 0.0676
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0205
Brugia malayi MH2 domain containing protein 0.0025 0.0042 0.0229
Schistosoma mansoni neutral sphingomyelinase 0.0012 0.0001 0.0006
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0001 0.0004
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0024 0.0132
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0081 0.0378
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0037 0.1976
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0183 1
Schistosoma mansoni nuclear receptor nhr-48 0.0023 0.0038 0.0188
Brugia malayi Intermediate filament tail domain containing protein 0.0135 0.0378 0.2051
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0001 0.0006
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.0118 0.0118
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0142 0.0707
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0142 0.0676
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0104
Loa Loa (eye worm) hypothetical protein 0.0064 0.0162 0.088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0016 0.0068
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0183 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0046 0.0231
Leishmania major hypothetical protein, conserved 0.0071 0.0183 1
Echinococcus multilocularis survival motor neuron protein 1 0.048 0.1437 0.1437
Schistosoma mansoni smad1 5 8 and 0.0025 0.0042 0.021
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.0118 0.0118
Schistosoma mansoni gabp alpha 0.0075 0.0196 0.0973
Loa Loa (eye worm) Smad1 0.0025 0.0042 0.0229
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0179 0.0515 0.0515
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0142 0.0707
Loa Loa (eye worm) hypothetical protein 0.0132 0.0371 0.201
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0009 0.0041
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0016 0.0031
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.0118 0.0642
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0183 0.0864
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0236 0.0688 0.3422
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0236 0.0688 0.2239
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.0118 0.0588
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0009 0.0035
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0104
Loa Loa (eye worm) hypothetical protein 0.0088 0.0235 0.1276
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0016 0.0068
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0029 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0068
Onchocerca volvulus 0.0023 0.0037 0.0176
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.0633 0.301
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0183 0.0379
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0009 0.0047
Echinococcus granulosus thyroid hormone receptor alpha 0.0023 0.0038 0.0123
Schistosoma mansoni hypothetical protein 0.0031 0.0062 0.0306
Plasmodium vivax vivapain-2 0.0016 0.0016 0.0613
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0197 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0016 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0016 0.0068
Leishmania major cathepsin L-like protease 0.0016 0.0016 0.079
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0167 0.0542
Onchocerca volvulus 0.0071 0.0183 0.0869
Brugia malayi hypothetical protein 0.0179 0.0515 0.2791
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0201
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0128 0.0604
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0047
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0104
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0104
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0128 0.0128
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0183 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0038 0.0123
Trypanosoma brucei glucosidase, putative 0.0037 0.0081 0.4375
Brugia malayi tailless protein 0.0023 0.0038 0.0205
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0205
Leishmania major cathepsin L-like protease 0.0062 0.0155 0.8468
Onchocerca volvulus 0.0135 0.0378 0.1798
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0118 0.0118
Brugia malayi orphan nuclear receptor NR2E1 0.0023 0.0038 0.0205
Echinococcus multilocularis tumor protein p63 0.1015 0.3075 0.3075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0068
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0119 0.6485
Echinococcus multilocularis FTZ F1 alpha 0.005 0.0118 0.0118
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0062 0.0062
Echinococcus granulosus microtubule associated protein 2 0.0668 0.2011 0.6542
Entamoeba histolytica hypothetical protein 0.0179 0.0515 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0001 0.0006
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0024 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0037 0.0038
Echinococcus granulosus synaptojanin 1 0.0012 0.0001 0.0004
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0038 0.018
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0183 0.0991
Brugia malayi steroid hormone receptor 0.005 0.0118 0.0642
Brugia malayi MH1 domain containing protein 0.0025 0.0042 0.0229
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0042 0.0137
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0081 0.3393
Schistosoma mansoni smad1 5 8 and 0.0025 0.0042 0.021
Onchocerca volvulus 0.0015 0.0011 0.0051
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0167 0.0167
Echinococcus granulosus lamin 0.0135 0.0378 0.1231
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0084 0.5908
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0042 0.0137
Onchocerca volvulus 0.0135 0.0378 0.1798
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0081 0.0081
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0024 0.0988
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.0118 0.0642
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0119 0.6485
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0155 0.8468
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0038 0.0188
Schistosoma mansoni Smad4 0.0025 0.0042 0.021
Schistosoma mansoni nuclear receptor 0.0023 0.0038 0.0188
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0205
Brugia malayi Smad1 0.0025 0.0042 0.0229
Brugia malayi nuclear receptor RXR 0.0023 0.0038 0.0205
Schistosoma mansoni lamin 0.0135 0.0378 0.1881
Schistosoma mansoni hypothetical protein 0.0031 0.0062 0.0306
Loa Loa (eye worm) fli-1 protein 0.0228 0.0664 0.3598
Schistosoma mansoni hypothetical protein 0.0331 0.0979 0.4868
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1577 0.4793 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0167 0.0904
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0128 0.5426
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0001 0.0006
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0016 0.0732
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.0118 0.0385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0155 0.8468
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0236 0.0688 0.3731
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0128 0.6996
Brugia malayi RNA recognition motif domain containing protein 0.0261 0.0764 0.4144
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0139 0.7565
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.0266 0.1442
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0019 0.0913
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0167 0.0829
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0037 0.0201
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0029 0.0093
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0197 0.8371
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0024 0.0988
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0042 0.0229
Loa Loa (eye worm) MBCTL1 0.0066 0.0167 0.0904
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0084
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0141 0.0141
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0024 0.1274
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0485 0.145 0.7859
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0118 0.0243
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0261 0.0764 0.4144
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0024 0.1274
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0009 0.0411
Loa Loa (eye worm) hypothetical protein 0.005 0.0118 0.0642
Brugia malayi hypothetical protein 0.0023 0.0038 0.0205
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0141 0.5956
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0118 0.0642
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0001 0.0006
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0183 0.7756
Brugia malayi beta-lactamase 0.0071 0.0183 0.0991
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.0118 0.0642
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0084 0.0272
Brugia malayi Cathepsin L-like precursor 0.0016 0.0016 0.0084
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.005 0.0118 0.0562
Leishmania major hypothetical protein, conserved 0.005 0.0119 0.6485
Leishmania major cathepsin L-like protease 0.0062 0.0155 0.8468
Loa Loa (eye worm) hypothetical protein 0.005 0.0118 0.0642
Loa Loa (eye worm) ctsf protein 0.0016 0.0016 0.0084
Schistosoma mansoni loxhd1 0.0021 0.0029 0.0143
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0205
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0062 0.0334
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0038 0.0188
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0081 0.0262
Brugia malayi MH1 domain containing protein 0.0014 0.0008 0.0044
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0024 0.0079
Echinococcus multilocularis microtubule associated protein 2 0.0668 0.2011 0.2011
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0119 0.503
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0118 0.0243
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0197 1
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0046 0.0252
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0046 0.2266
Echinococcus multilocularis neutral sphingomyelinase 0.0012 0.0001 0.0001
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0016 0.079
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0128 0.6996
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0183 0.0909
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0035 0.0035
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0084 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0068
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0046 0.2266
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0038 0.0205
Echinococcus granulosus GA binding protein alpha chain 0.0075 0.0196 0.0637
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0026 0.0046 0.0252
Echinococcus granulosus FTZ F1 alpha 0.005 0.0118 0.0385
Echinococcus granulosus tar DNA binding protein 0.0261 0.0764 0.2486
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0236 0.0688 0.3422
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0183 0.0379
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0141 0.0291
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0024 0.1274
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0072 0.0187 0.1013
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0046 0.1896
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0016 0.0016
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0141 0.7679
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0155 0.8468
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.0118 0.0642
Schistosoma mansoni hypothetical protein 0.0179 0.0515 0.256
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0068
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0009 0.0035
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0141 0.0763
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0142 0.0461
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0183 0.0991
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0023 0.0038 0.0038
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0009 0.0035
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0016 0.0074
Onchocerca volvulus 0.0158 0.0448 0.213
Brugia malayi hypothetical protein 0.0026 0.0046 0.0252
Entamoeba histolytica hypothetical protein 0.0179 0.0515 1
Brugia malayi hypothetical protein 0.0026 0.0046 0.0252
Brugia malayi hypothetical protein 0.0021 0.0029 0.0156
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0197 0.8371
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0128 0.6996
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0142 0.0707
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0009 0.0411
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0001 0.0006
Loa Loa (eye worm) transcription factor SMAD2 0.0366 0.1085 0.5884
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0029 0.0029
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0016 0.0084
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.0118 0.0588
Loa Loa (eye worm) hypothetical protein 0.005 0.0118 0.0642
Schistosoma mansoni nocturnin 0.0012 0.0001 0.0006
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0037 0.0038
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0183 0.0909
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0042 0.0042
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0001 0.0006
Echinococcus multilocularis GPCR, family 2 0.0031 0.0062 0.0062
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0142 0.0463
Echinococcus multilocularis thyroid hormone receptor alpha 0.005 0.0118 0.0118
Mycobacterium tuberculosis Conserved protein 0.0071 0.0183 0.0379
Schistosoma mansoni hypothetical protein 0.0067 0.0173 0.0858
Echinococcus multilocularis Smad4 0.0025 0.0042 0.0042
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0081 0.0378
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0141 0.0663
Loa Loa (eye worm) hypothetical protein 0.0026 0.0046 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.0118 0.0642
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0062 0.0334
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0024 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0081 0.4375
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0141 0.7679
Brugia malayi Probable ClpP-like protease 0.0076 0.0197 0.1069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0155 0.8468
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0088 0.0235 0.117
Loa Loa (eye worm) RNA binding protein 0.0261 0.0764 0.4144
Schistosoma mansoni rab6-interacting 0.0021 0.0029 0.0143
Echinococcus granulosus intermediate filament protein 0.0135 0.0378 0.1231
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0016 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0068
Brugia malayi Glycosyl hydrolases family 31 protein 0.0169 0.0483 0.2618
Loa Loa (eye worm) TAR-binding protein 0.0261 0.0764 0.4144
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0236 0.0688 0.2239
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0085 0.0225 0.0733
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0084 0.0272
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0016 0.0016
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0012 0.0001 0.0004
Echinococcus multilocularis smad 0.0025 0.0042 0.0042
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0128 0.0695
Brugia malayi hypothetical protein 0.0021 0.0029 0.0156
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0141 0.7679
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0236 0.0688 0.0688
Schistosoma mansoni smad 0.0025 0.0042 0.021
Schistosoma mansoni nuclear hormone receptor 0.005 0.0118 0.0588
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0084 0.4536
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0081 0.1547
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0009 0.0411
Brugia malayi mbt repeat family protein 0.0058 0.0142 0.0771
Loa Loa (eye worm) hypothetical protein 0.005 0.0118 0.0642
Loa Loa (eye worm) hypothetical protein 0.005 0.0118 0.0642
Loa Loa (eye worm) hypothetical protein 0.005 0.0118 0.0642
Schistosoma mansoni smad1 5 8 and 0.0025 0.0042 0.021
Schistosoma mansoni alpha-glucosidase 0.0145 0.0411 0.2044
Schistosoma mansoni hypothetical protein 0.0031 0.0062 0.0306
Brugia malayi Cathepsin L-like precursor 0.0016 0.0016 0.0084
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0009 0.0035
Echinococcus granulosus lamin dm0 0.0135 0.0378 0.1231
Leishmania major cathepsin L-like protease 0.0016 0.0016 0.079
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0084 0.4536
Brugia malayi nuclear receptor NHR-88 0.005 0.0118 0.0642
Onchocerca volvulus 0.0016 0.0016 0.0074
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0016 0.0084
Schistosoma mansoni cript-related 0.0012 0.0001 0.0006
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.0118 0.0642
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0084 0.0392
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0453
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0128 0.6996
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0205
Mycobacterium tuberculosis Conserved protein 0.0071 0.0183 0.0379
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0026 0.0046 0.0046
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0183 0.0306
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0024 0.0048
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0019 0.0764
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0362 0.1073 0.5337
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0183 0.0864
Echinococcus multilocularis lamin dm0 0.0135 0.0378 0.0378
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0001 0.0006
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0119 0.503
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0062 0.0334
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0016 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0068
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0197 0.0337
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0081 0.0378
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0183 0.0379
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0088 0.0235 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0141 0.7115
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0081 0.0378
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0118 0.0118
Brugia malayi beta-lactamase family protein 0.0071 0.0183 0.0991
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0029 0.1176
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.0118 0.0118
Onchocerca volvulus 0.0021 0.0029 0.0137
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0331 0.0979 0.4868
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0062 0.02
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0183 0.0379
Echinococcus multilocularis deoxyribonuclease 1 2 0.0012 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0071 0.0183 0.0991
Echinococcus granulosus traf and tnf receptor associated protein 0.0012 0.0001 0.0004
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0009 0.0035
Echinococcus granulosus Smad4 0.0025 0.0042 0.0137
Brugia malayi Doublecortin family protein 0.0021 0.0029 0.0156
Echinococcus granulosus retinoic acid receptor rxr beta a 0.005 0.0118 0.0385
Onchocerca volvulus 0.0016 0.0016 0.0074
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0167 0.0167
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0081 0.1547
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.0118 0.0118
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0142 0.0771
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0142 0.0142
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0128 0.0604
Schistosoma mansoni synaptojanin 0.0012 0.0001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0071 0.0183 0.0991
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0201
Loa Loa (eye worm) hypothetical protein 0.0076 0.0197 0.1069
Loa Loa (eye worm) cysteine protease 0.0016 0.0016 0.0084
Loa Loa (eye worm) hypothetical protein 0.0026 0.0046 0.0252
Schistosoma mansoni rab6-interacting 0.0021 0.0029 0.0143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0155 0.8468
Loa Loa (eye worm) hypothetical protein 0.005 0.0118 0.0642
Onchocerca volvulus 0.0016 0.0016 0.0074
Loa Loa (eye worm) MH2 domain-containing protein 0.0366 0.1085 0.5884
Onchocerca volvulus 0.0016 0.0016 0.0074
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0037 0.0038
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0155 0.8468
Trichomonas vaginalis set domain proteins, putative 0.0698 0.2104 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0009 0.0035
Loa Loa (eye worm) nuclear receptor NHR-67 0.0023 0.0038 0.0205
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0141 0.2715
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0118 0.0642
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0239 0.0696 0.2264
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0016 0.0084
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0037 0.0699
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0035 0.0112
Mycobacterium ulcerans TetR family transcriptional regulator 0.1577 0.4793 1
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0001 0.0001
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0084 0.0416
Loa Loa (eye worm) hypothetical protein 0.0071 0.0183 0.0991
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0068
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0081 0.0437
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.0483 0.0483
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0038 0.0038
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.0118 0.0588
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0155 0.8468
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0006
Schistosoma mansoni thyroid hormone receptor 0.005 0.0118 0.0588
Brugia malayi Ets-domain containing protein 0.0075 0.0196 0.1061
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.0118 0.0385
Trypanosoma brucei protein kinase, putative 0.0053 0.0128 0.6996
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0088 0.0235 0.117
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0141 0.0458
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0205
Loa Loa (eye worm) hypothetical protein 0.048 0.1437 0.7791
Onchocerca volvulus 0.0021 0.0029 0.0137
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0029 0.1405
Brugia malayi hypothetical protein 0.0158 0.0448 0.243
Brugia malayi beta-lactamase family protein 0.0071 0.0183 0.0991
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0026 0.0046 0.0231
Echinococcus multilocularis neuropeptide s receptor 0.0562 0.1686 0.1686
Onchocerca volvulus 0.0698 0.2104 1
Echinococcus multilocularis lamin 0.0135 0.0378 0.0378
Schistosoma mansoni intermediate filament proteins 0.0135 0.0378 0.1881
Brugia malayi Cathepsin L-like precursor 0.0016 0.0016 0.0084
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0197 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0084 0.0416
Onchocerca volvulus 0.0098 0.0266 0.1264
Echinococcus multilocularis tar DNA binding protein 0.0261 0.0764 0.0764
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0118 0.0642
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0068
Schistosoma mansoni polycystin 1-related 0.0021 0.0029 0.0143
Onchocerca volvulus 0.0088 0.0235 0.1119
Mycobacterium ulcerans hypothetical protein 0.0071 0.0183 0.0343
Mycobacterium ulcerans hypothetical protein 0.0023 0.0037 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0128 0.0638
Schistosoma mansoni tar DNA-binding protein 0.0261 0.0764 0.3801
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.0118 0.0385
Loa Loa (eye worm) hypothetical protein 0.0063 0.0157 0.0853
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0142 0.0142
Onchocerca volvulus 0.0023 0.0038 0.018
Loa Loa (eye worm) hypothetical protein 0.0071 0.0183 0.0991
Echinococcus granulosus histone lysine methyltransferase setb 0.0088 0.0235 0.0766
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0142 0.0463
Mycobacterium tuberculosis Conserved protein 0.0071 0.0183 0.0379
Brugia malayi MH2 domain containing protein 0.0025 0.0042 0.0229
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.0118 0.0642
Loa Loa (eye worm) hypothetical protein 0.005 0.0118 0.0642
Mycobacterium ulcerans beta-lactamase 0.0071 0.0183 0.0343
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0141 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0065 0.0165 0.0165
Leishmania major cathepsin L-like protease 0.0016 0.0016 0.079
Brugia malayi N-terminal motif family protein 0.0218 0.0633 0.3434
Schistosoma mansoni tar DNA-binding protein 0.0261 0.0764 0.3801
Schistosoma mansoni transcription factor LCR-F1 0.0179 0.0515 0.256
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0141 0.0663
Schistosoma mansoni tar DNA-binding protein 0.0261 0.0764 0.3801
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0006
Toxoplasma gondii hypothetical protein 0.0026 0.0046 0.1896
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0038 0.0123
Echinococcus multilocularis neuropeptide receptor A26 0.0562 0.1686 0.1686
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0001 0.0006
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0038 0.0038
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0141 0.7115
Schistosoma mansoni survival motor neuron protein 0.0098 0.0266 0.1323
Echinococcus granulosus neuropeptide s receptor 0.0562 0.1686 0.5483
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.0118 0.0642
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.0118 0.0642
Onchocerca volvulus Putative neutral sphingomyelinase 0.0012 0.0001 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.0118 0.0642
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0128 0.0417
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0019 0.0037
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0268 0.1454
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0037 0.0201
Brugia malayi Pre-SET motif family protein 0.0088 0.0235 0.1276
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1577 0.4793 1
Onchocerca volvulus Bile acid receptor homolog 0.005 0.0118 0.0562
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0236 0.0688 0.0688
Brugia malayi Cathepsin L-like precursor 0.0016 0.0016 0.0084
Brugia malayi hypothetical protein 0.0032 0.0065 0.0351
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0037 0.0038
Onchocerca volvulus 0.0016 0.0016 0.0074
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0169 0.0483 0.2618
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0128 0.6996
Schistosoma mansoni lipoxygenase 0.0057 0.0142 0.0705
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0614 0.1845 1
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0155 0.8468
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0183 0.0183
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0155 0.8468
Onchocerca volvulus Protein ultraspiracle homolog 0.005 0.0118 0.0562
Brugia malayi nuclear receptor NHR-67 0.0023 0.0038 0.0205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.0118 0.0642
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0016 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0081 0.4375
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0016 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0068
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0081 0.0378
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0118 0.0642
Schistosoma mansoni tar DNA-binding protein 0.0261 0.0764 0.3801
Schistosoma mansoni hypothetical protein 0.0022 0.0035 0.0172
Echinococcus granulosus geminin 0.0331 0.0979 0.3185
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0081 0.0378
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0037 0.0038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0016 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0155 0.8468
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0038 0.0038
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0197 0.8371
Schistosoma mansoni hypothetical protein 0.0098 0.0266 0.1323
Brugia malayi intermediate filament protein 0.0135 0.0378 0.2051
Loa Loa (eye worm) intermediate filament protein 0.0135 0.0378 0.2051
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0084 0.0392
Entamoeba histolytica hypothetical protein 0.0179 0.0515 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0024 0.0024
Schistosoma mansoni zinc finger protein 0.0023 0.0038 0.0188
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0024 0.0988
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0016 0.0016
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.0118 0.0588
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0016 0.0031
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0084 0.0392
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0128 0.0604
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0155 0.8468
Brugia malayi conserved hypotetical protein 0.0023 0.0038 0.0205
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0038 0.0205
Loa Loa (eye worm) hypothetical protein 0.0066 0.0167 0.0904
Echinococcus multilocularis RUN 0.0021 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0205
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0037 0.0075
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0037 0.0699
Entamoeba histolytica cysteine protease, putative 0.0016 0.0016 0.0279
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0023 0.0038 0.0188
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0006
Brugia malayi CCR4 0.0012 0.0001 0.0006
Brugia malayi nuclear hormone receptor 0.0023 0.0038 0.0205
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0084 0.0272
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0009 0.0035
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0128 0.6996
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0128 0.6996
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.0118 0.0118
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0012 0.0004 0.016
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0119 0.6008
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0016 0.0279
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0084 0.4536
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0029 0.0093
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.0118 0.0588
Echinococcus granulosus survival motor neuron protein 1 0.048 0.1437 0.4674
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0128 0.0128
Onchocerca volvulus 0.0098 0.0265 0.1259
Loa Loa (eye worm) hypothetical protein 0.0026 0.0046 0.0252
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0179 0.0515 0.1675
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0183 0.0379
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0453 0.1352 0.2818
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0068
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0156
Brugia malayi Fli-1 protein 0.0228 0.0664 0.3598
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0118 0.0169
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0037 0.0038
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0115 0.624
Loa Loa (eye worm) hypothetical protein 0.0135 0.0378 0.2051
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0119 0.6008
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0118 0.0382
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0023 0.0038 0.0205
Brugia malayi nuclear receptor RXR 0.0026 0.0046 0.0252
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0156
Brugia malayi ecdysteroid receptor 0.005 0.0118 0.0642
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0118 0.0642
Echinococcus granulosus tumor protein p63 0.1015 0.3075 1
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0029 0.0093
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0155 0.8468
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1577 0.4793 1
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0046 0.0252
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0009 0.0411
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0197 0.0642
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0088 0.0235 0.117
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.0118 0.0642
Brugia malayi nuclear hormone receptor 0.005 0.0118 0.0642
Schistosoma mansoni ets-related 0.0228 0.0664 0.33
Leishmania major cathepsin L-like protease 0.0016 0.0016 0.079
Brugia malayi isocitrate dehydrogenase 0.0019 0.0024 0.0132
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0006
Schistosoma mansoni hypothetical protein 0.0031 0.0062 0.0306
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0001 0.0006
Loa Loa (eye worm) nuclear hormone receptor 0.0023 0.0038 0.0205
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0016 0.0068
Schistosoma mansoni tar DNA-binding protein 0.0261 0.0764 0.3801
Loa Loa (eye worm) hypothetical protein 0.0031 0.0062 0.0334
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0016 0.0068
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0081 0.0378
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0001 0.0006
Brugia malayi Cathepsin L-like precursor 0.0016 0.0016 0.0084
Schistosoma mansoni lipoxygenase 0.0021 0.0029 0.0143
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0062 0.02
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0042 0.0229
Loa Loa (eye worm) nuclear factor I 0.0014 0.0008 0.0044
Echinococcus multilocularis geminin 0.0331 0.0979 0.0979
Echinococcus granulosus RUN 0.0021 0.0029 0.0093
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0142 0.0142
Schistosoma mansoni thyroid hormone receptor 0.005 0.0118 0.0588
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0012 0.0001 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0236 0.0688 0.3422
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0135 0.0378 0.2051
Echinococcus granulosus smad 0.0025 0.0042 0.0137
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0081 0.4375
Loa Loa (eye worm) hypothetical protein 0.0065 0.0165 0.0894
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0183 0.0379
Schistosoma mansoni retinoic acid receptor RXR 0.005 0.0118 0.0588
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0173 0.0935
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0023 0.0038 0.0205
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0118 0.0118
Brugia malayi MH1 domain containing protein 0.0014 0.0008 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0155 0.8468
Echinococcus multilocularis GA binding protein alpha chain 0.0075 0.0196 0.0196
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0024 0.1274
Echinococcus granulosus nuclear receptor nhr 48 0.0023 0.0038 0.0123
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0205
Brugia malayi ecdysone receptor 0.0023 0.0038 0.0205
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0065 0.0165 0.0536
Echinococcus granulosus cathepsin l1 0.0016 0.0016 0.0051
Echinococcus granulosus neuropeptide receptor A26 0.0562 0.1686 0.5483
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0016 0.0068
Schistosoma mansoni carbon catabolite repressor protein 0.0012 0.0001 0.0006
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0081 0.0378
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0201
Toxoplasma gondii cathepsin CPL 0.0016 0.0016 0.0613
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0016 0.0732
Loa Loa (eye worm) hypothetical protein 0.0071 0.0183 0.0991
Brugia malayi nuclear receptor NHR-88 0.0023 0.0038 0.0205
Brugia malayi MH2 domain containing protein 0.0366 0.1085 0.5884
Entamoeba histolytica hypothetical protein 0.0179 0.0515 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0009 0.0145
Brugia malayi MAP kinase sur-1 0.0053 0.0128 0.0695
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0016 0.0031
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0128 0.0604
Loa Loa (eye worm) hypothetical protein 0.0058 0.0142 0.0771
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0155 0.8468
Leishmania major cathepsin L-like protease 0.0016 0.0016 0.079
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.0118 0.0385
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0183 0.0864
Echinococcus multilocularis synaptojanin 1 0.0012 0.0001 0.0001
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0183 0.0864
Brugia malayi hypothetical protein 0.0023 0.0038 0.0205
Loa Loa (eye worm) beta-lactamase 0.0071 0.0183 0.0991
Loa Loa (eye worm) hypothetical protein 0.0099 0.0268 0.1454
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0029 0.0156
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0141 0.0763
Brugia malayi Cathepsin L-like precursor 0.0016 0.0016 0.0084
Onchocerca volvulus 0.0012 0.0001 0.0006
Echinococcus granulosus neutral sphingomyelinase 0.0012 0.0001 0.0004
Onchocerca volvulus 0.0149 0.0421 0.2
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0183 0.0343
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0197 0.0373
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0118 0.0385
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0016 0.079
Leishmania major pantothenate kinase subunit, putative 0.0012 0.0004 0.016
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0009 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.0118 0.0642
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0088 0.0235 0.117
Loa Loa (eye worm) fibroinase 0.0016 0.0016 0.0084
Brugia malayi nuclear hormone receptor family member nhr-6 0.0023 0.0038 0.0205
Schistosoma mansoni cellular tumor antigen P53 0.0149 0.0421 0.2093
Brugia malayi hypothetical protein 0.048 0.1437 0.7791
Loa Loa (eye worm) steroid hormone receptor 0.005 0.0118 0.0642
Echinococcus granulosus lysosomal alpha glucosidase 0.0169 0.0483 0.1571
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.0483 0.0483
Onchocerca volvulus 0.005 0.0118 0.0562
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0118 0.0642
Schistosoma mansoni microtubule-associated protein tau 0.0668 0.2011 1
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0128 0.0417
Echinococcus granulosus GPCR family 2 0.0031 0.0062 0.02
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0183 0.0379
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0016 0.0068
Brugia malayi cytoplasmic intermediate filament protein 0.0072 0.0187 0.1013
Schistosoma mansoni alpha-glucosidase 0.0145 0.0411 0.2044
Loa Loa (eye worm) hypothetical protein 0.005 0.0119 0.0645
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0088 0.0235 0.0235
Schistosoma mansoni ap endonuclease 0.0057 0.0141 0.0699
Onchocerca volvulus 0.0071 0.0183 0.0869
Brugia malayi hypothetical protein 0.005 0.0119 0.0645
Schistosoma mansoni coup transcription factor 0.005 0.0118 0.0588
Plasmodium vivax SET domain protein, putative 0.0088 0.0235 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0001 0.0006
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0001 0.0006
Brugia malayi RNA binding protein 0.0261 0.0764 0.4144
Loa Loa (eye worm) hypothetical protein 0.0149 0.0421 0.2282
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0236 0.0688 0.3731
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0075 0.0196 0.1061
Loa Loa (eye worm) hypothetical protein 0.0218 0.0633 0.3434
Schistosoma mansoni hypothetical protein 0.0021 0.0029 0.0143
Loa Loa (eye worm) hypothetical protein 0.0026 0.0046 0.0252
Mycobacterium leprae Probable lipase LipE 0.0071 0.0183 0.0306
Brugia malayi nuclear hormone receptor family member odr-7 0.0023 0.0038 0.0205
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0037 0.1976
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0084 0.1604
Toxoplasma gondii ABC1 family protein 0.0071 0.0183 0.7756
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0037 0.0699
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0081 0.0378
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0016 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0118 0.0642
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0023 0.0038 0.0123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.0118 0.0642
Onchocerca volvulus 0.0071 0.0183 0.0869
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0016 0.0077
Brugia malayi MH1 domain containing protein 0.0025 0.0042 0.0229
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0038 0.0123
Schistosoma mansoni ap endonuclease 0.0057 0.0141 0.0699
Loa Loa (eye worm) hypothetical protein 0.0158 0.0448 0.243
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0062 0.0062
Mycobacterium ulcerans transcriptional regulator 0.1577 0.4793 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0046 0.0252
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.0118 0.0588
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0024 0.118
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0084 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0068
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0155 0.8468
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0001 0.0006
Brugia malayi Pre-SET motif family protein 0.0614 0.1845 1
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0016 0.0074
Brugia malayi Ets-domain containing protein 0.0075 0.0196 0.1061
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0037 0.0038
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0037 0.0201
Echinococcus multilocularis traf and tnf receptor associated protein 0.0012 0.0001 0.0001
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0037 0.1976
Echinococcus multilocularis cysteine protease 0.0016 0.0016 0.0016
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0012 0.0001 0.0001

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 1.3115 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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