Detailed information for compound 1337843

Basic information

Technical information
  • TDR Targets ID: 1337843
  • Name: 2-(3-methoxyphenyl)-N-pyridin-4-ylquinazolin- 4-amine
  • MW: 328.367 | Formula: C20H16N4O
  • H donors: 1 H acceptors: 3 LogP: 3.98 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)c1nc(Nc2ccncc2)c2c(n1)cccc2
  • InChi: 1S/C20H16N4O/c1-25-16-6-4-5-14(13-16)19-23-18-8-3-2-7-17(18)20(24-19)22-15-9-11-21-12-10-15/h2-13H,1H3,(H,21,22,23,24)
  • InChiKey: WIEHKHRKXABTRA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(3-methoxyphenyl)-N-(4-pyridyl)quinazolin-4-amine
  • 2-(3-methoxyphenyl)-N-(4-pyridyl)-4-quinazolinamine
  • [2-(3-methoxyphenyl)quinazolin-4-yl]-(4-pyridyl)amine
  • 2-(3-methoxyphenyl)-N-pyridin-4-yl-quinazolin-4-amine
  • NCGC00012917
  • PCOP-974706

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0024 0.0024
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0316 0.0439
Brugia malayi MAP kinase sur-1 0.0062 0.0666 0.0925
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.007 0.007
Schistosoma mansoni neuropeptide receptor 0.0008 0.0024 0.0024
Echinococcus granulosus g protein coupled receptor 0.0008 0.0024 0.0024
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0352 0.0352
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0063 0.0679 0.0943
Onchocerca volvulus 0.0033 0.0316 0.0407
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.1118 0.1118
Plasmodium vivax JmjC domain containing protein 0.0015 0.0108 0.2981
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Schistosoma mansoni smad 0.0008 0.0019 0.0019
Echinococcus granulosus neuropeptide s receptor 0.0008 0.0024 0.0024
Echinococcus granulosus G protein coupled receptor 139 0.0008 0.0024 0.0024
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0193 0.1513
Schistosoma mansoni vesicular acetylcholine transporter 0.0437 0.5209 0.5209
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0039 0.0039
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0621 0.0621
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.007 0.0097
Loa Loa (eye worm) Smad1 0.0008 0.0019 0.0026
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0008 0.0024 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0024 0.0024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0024 0.0024
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.007 0.007
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0352 0.497
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5895 0.5895
Schistosoma mansoni ferritin 0.0008 0.0022 0.0022
Schistosoma mansoni opsin-like receptor 0.0008 0.0024 0.0024
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0155 0.0155
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0666 0.2435
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0193 0.2429
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0193 0.0659
Echinococcus granulosus orexin receptor type 2 0.0008 0.0024 0.0024
Brugia malayi MH2 domain containing protein 0.0008 0.0019 0.0026
Echinococcus granulosus neuropeptide FF receptor 2 0.0008 0.0024 0.0024
Entamoeba histolytica calpain large subunit domain III containing protein 0.0019 0.0147 0.3523
Echinococcus multilocularis calpain 0.0019 0.0147 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.007 0.0097
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0017 0.00000000036032
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0008 0.0024 0.0024
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0352 0.0352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.1118 0.1118
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0022 0.0194 0.6513
Brugia malayi hypothetical protein 0.0008 0.0024 0.0033
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.007 0.007
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0666 0.0666
Schistosoma mansoni alpha-1 adrenergic receptor 0.0008 0.0024 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.007 0.0097
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0039 0.0039
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0016 0.012 0.0216
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.1118 0.1118
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0019 0.0019
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.0494 0.5895 0.5895
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0399 0.0554
Brugia malayi putative neuropeptide receptor NPR1 0.0008 0.0024 0.0033
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0039 0.0039
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0022 0.0194 0.2839
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0024 0.0024
Echinococcus granulosus intermediate filament protein 0.0033 0.0316 0.0316
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0008 0.0024 0.0033
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.134 0.1861
Brugia malayi calpain family protein 1 0.0063 0.0679 0.0943
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.007 0.0097
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0097
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0193 0.0268
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.007 0.007
Schistosoma mansoni amine GPCR 0.0008 0.0024 0.0024
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0645 0.0645
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.007 0.0097
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0108 0.0108
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0352 0.1255
Onchocerca volvulus 0.0029 0.0278 0.0354
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0105 0.0146
Echinococcus multilocularis hypothetical protein 0.0019 0.0147 0.0147
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0024 0.0024
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0016 0.012 0.1629
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0097
Schistosoma mansoni cpg binding protein 0.0037 0.0365 0.0365
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0666 0.0666
Schistosoma mansoni thyroid hormone receptor 0.0012 0.007 0.007
Trypanosoma cruzi kinesin, putative 0.0019 0.0147 0.1704
Schistosoma mansoni aldehyde dehydrogenase 0.0058 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Echinococcus multilocularis somatostatin receptor 0.0008 0.0024 0.0024
Loa Loa (eye worm) TYRA-2 protein 0.0008 0.0024 0.0033
Echinococcus granulosus biogenic amine 5HT receptor 0.0008 0.0024 0.0024
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0016 0.012 0.1629
Echinococcus granulosus expressed protein 0.0008 0.0022 0.0022
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0248 0.0345
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0019 0.0155 0.0215
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0008 0.0024 0.0024
Leishmania major cytochrome p450-like protein 0.0027 0.0248 0.251
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0666 1
Echinococcus multilocularis Smad4 0.0008 0.0019 0.0019
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0278 0.0278
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0352 0.0352
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0147 0.07
Echinococcus granulosus tachykinin peptides receptor 99D 0.0008 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0008 0.0024 0.0024
Trypanosoma brucei kinesin, putative 0.0019 0.0147 0.07
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0017 0.00000000036032
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0193 0.4961
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.007 0.0097
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0016 0.012 0.0216
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0024 0.0024
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0108 0.0108
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0108 0.108
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0024 0.0024
Echinococcus granulosus Smad4 0.0008 0.0019 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0278 0.0278
Schistosoma mansoni ap endonuclease 0.0022 0.0193 0.0193
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0352 0.1255
Brugia malayi jmjC domain containing protein 0.0015 0.0108 0.015
Loa Loa (eye worm) RecQ helicase 0.0019 0.0155 0.0215
Brugia malayi G-protein coupled receptor 0.0008 0.0024 0.0033
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0155 0.5468
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0019 0.0019
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0017 0.00000000036032
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0193 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.007 0.0097
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0155 0.1826
Echinococcus granulosus calpain 0.0019 0.0147 0.0147
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0008 0.0024 0.0024
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Brugia malayi G protein-coupled receptor 0.0008 0.0024 0.0033
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0666 0.2435
Schistosoma mansoni hypothetical protein 0.0008 0.0024 0.0024
Echinococcus granulosus somatostatin receptor 0.0008 0.0024 0.0024
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0016 0.012 0.1629
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0016 0.012 0.1629
Schistosoma mansoni adenoreceptor 0.0008 0.0024 0.0024
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0108 0.0108
Brugia malayi Dopamine receptor protein 1 0.0008 0.0024 0.0033
Echinococcus granulosus neuropeptide receptor 0.0008 0.0024 0.0024
Schistosoma mansoni biogenic amine receptor 0.0008 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.007 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0024 0.0024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.1118 0.1118
Brugia malayi Cytochrome P450 family protein 0.0016 0.012 0.0167
Echinococcus multilocularis calpain A 0.0066 0.0718 0.0718
Leishmania major cytochrome p450-like protein 0.0016 0.012 0.0216
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0437 0.5209 0.7235
Brugia malayi Dopamine receptor protein 2 0.0008 0.0024 0.0033
Schistosoma mansoni intermediate filament proteins 0.0033 0.0316 0.0316
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0155 0.0155
Brugia malayi GnHR receptor homolog 0.0008 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0108 0.104
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0108 0.015
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.1118 0.1553
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0016 0.012 0.1629
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0155 0.1713
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0016 0.012 0.1629
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5895 0.5895
Schistosoma mansoni hypothetical protein 0.0015 0.0105 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.007 0.0097
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0194 0.153
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0016 0.012 0.1273
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0182 0.0182
Brugia malayi hypothetical protein 0.0008 0.0024 0.0033
Echinococcus granulosus tm gpcr rhodopsin 0.051 0.6092 0.6092
Echinococcus multilocularis dro:myosuppressin receptor 0.0008 0.0024 0.0024
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0155 0.0215
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0057
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0008 0.0024 0.0033
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0024 0.0024
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0147 0.07
Brugia malayi Pre-SET motif family protein 0.0201 0.2349 0.3263
Schistosoma mansoni biogenic amine receptor 0.0008 0.0024 0.0024
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0041 0.0041
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0097
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.0024 0.0033
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0008 0.0024 0.0033
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0058 0.0627 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.007 0.007
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.007 0.0097
Echinococcus multilocularis g protein coupled receptor 0.0008 0.0024 0.0024
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0108 0.0108
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0058 0.0627 0.0627
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.007 0.0097
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0248 0.3741
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0016 0.012 0.1629
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0316 0.0439
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0024 0.0024
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.007 0.007
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.007 0.007
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0008 0.0024 0.0033
Schistosoma mansoni neuropeptide receptor 0.0008 0.0024 0.0024
Echinococcus granulosus neuropeptides capa receptor 0.0008 0.0024 0.0024
Schistosoma mansoni opsin-like receptor 0.0008 0.0024 0.0024
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0022 0.0194 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0278 0.0278
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.007 0.007
Echinococcus granulosus FTZ F1 alpha 0.0012 0.007 0.007
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0022 0.0194 0.2271
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0016 0.012 0.1629
Brugia malayi Cytochrome P450 family protein 0.0039 0.0399 0.0554
Echinococcus multilocularis GPCR, family 2 0.0015 0.0105 0.0105
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0008 0.0024 0.0024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0017 0.00000000036032
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0016 0.012 0.1629
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0352 0.0488
Mycobacterium leprae Conserved hypothetical protein 0.0016 0.012 0.5737
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0147 0.07
Echinococcus granulosus sex peptide receptor 0.0008 0.0024 0.0024
Entamoeba histolytica protein kinase, putative 0.0019 0.0154 0.3736
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.007 0.007
Brugia malayi hypothetical protein 0.0602 0.72 1
Schistosoma mansoni hypothetical protein 0.0015 0.0105 0.0105
Schistosoma mansoni thyroid hormone receptor 0.0012 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0029 0.0278 0.0386
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0039 0.0039
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0008 0.0024 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.007 0.0097
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0155 0.0837
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0645 0.0645
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0147 0.1704
Brugia malayi G-protein coupled receptor 0.0008 0.0024 0.0033
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0666 0.2435
Echinococcus multilocularis neuropeptide receptor 0.0008 0.0024 0.0024
Schistosoma mansoni amine GPCR 0.0008 0.0024 0.0024
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0016 0.012 0.1629
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Echinococcus granulosus 7TM GPCR rhodopsin 0.0008 0.0024 0.0024
Trypanosoma brucei protein kinase, putative 0.0062 0.0666 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Mycobacterium ulcerans aldehyde dehydrogenase 0.0058 0.0627 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0016 0.012 0.1629
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0824 0.0824
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0501 0.0696
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0024 0.0024
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0155 0.0155
Brugia malayi MH2 domain containing protein 0.0117 0.134 0.1861
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0645 0.0895
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0108 0.0108
Schistosoma mansoni lamin 0.0033 0.0316 0.0316
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0667 0.0667
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.007 0.0097
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0058 0.0627 0.9305
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0155 0.0517
Schistosoma mansoni neuropeptide receptor 0.0008 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Schistosoma mansoni myosin xvIII 0.0008 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0048 0.0501 0.0696
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0155 0.1713
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0097
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0008 0.0024 0.0024
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0017 0.00000000036032
Leishmania major cytochrome p450-like protein 0.0016 0.012 0.0216
Loa Loa (eye worm) RNA binding protein 0.0062 0.0667 0.0926
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0147 0.0147
Echinococcus multilocularis neuropeptide s receptor 0.0008 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0008 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0044 0.0454 0.063
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0248 0.3319
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0667 0.0926
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0022 0.0194 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0108 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0352 0.1255
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0016 0.012 0.1629
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0666 0.0666
Brugia malayi hypothetical protein 0.0008 0.0024 0.0033
Brugia malayi intermediate filament protein 0.0033 0.0316 0.0439
Toxoplasma gondii aldehyde dehydrogenase 0.0058 0.0627 0.8529
Echinococcus granulosus cytochrome P450 2K1 0.0016 0.012 0.012
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0008 0.0024 0.0024
Brugia malayi neuropeptide F receptor 0.0008 0.0024 0.0033
Brugia malayi MH2 domain containing protein 0.0008 0.0019 0.0026
Brugia malayi Serotonin receptor 0.0008 0.0024 0.0033
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0666 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.007 0.0097
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0057
Schistosoma mansoni coup transcription factor 0.0012 0.007 0.007
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0008 0.0024 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0667 0.0667
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0041 0.0187
Echinococcus granulosus lamin 0.0033 0.0316 0.0316
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0437 0.5209 0.7225
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0008 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.008 0.0888 0.1233
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0019 0.0026
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0108 0.104
Echinococcus granulosus cpg binding protein 0.0037 0.0365 0.0365
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.007 0.0097
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0667 0.0667
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0193 0.0268
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.007 0.0064
Loa Loa (eye worm) hypothetical protein 0.0015 0.0108 0.015
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0193 0.1513
Schistosoma mansoni neuropeptide f receptor 76f 0.0008 0.0024 0.0024
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Echinococcus granulosus serotonin receptor 0.0008 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0146
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0066 0.0718 0.0718
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0352 0.4361
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.1118 0.1118
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0017 0.00000000036032
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0105 0.0105
Brugia malayi hypothetical protein 0.0008 0.0024 0.0033
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0016 0.012 0.1629
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0147 0.0147
Echinococcus multilocularis musashi 0.0033 0.0316 0.0316
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.134 0.1861
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0008 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Echinococcus granulosus g-protein coupled receptor 0.0008 0.0024 0.0024
Leishmania major kinesin, putative 0.0019 0.0147 0.07
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Echinococcus multilocularis g protein coupled receptor 0.0008 0.0024 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0024 0.0024
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0024 0.0024
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0666 0.0925
Echinococcus multilocularis ferritin 0.0008 0.0022 0.0022
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.007 0.007
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.007 0.0097
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0666 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0248 0.0345
Echinococcus multilocularis smad 0.0008 0.0019 0.0019
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0016 0.012 0.1629
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0147 0.1704
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0108 0.015
Trypanosoma cruzi kinesin, putative 0.0019 0.0147 0.1704
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0016 0.012 0.1629
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0155 0.0215
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0621 0.0621
Echinococcus granulosus calpain A 0.0066 0.0718 0.0718
Brugia malayi follicle stimulating hormone receptor 0.0229 0.2696 0.3745
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.2696 0.3745
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0352 0.3847
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0666 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0193 0.2429
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Echinococcus granulosus neuropeptide Y receptor 0.0008 0.0024 0.0024
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0015 0.0105 0.0105
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0016 0.012 0.1629
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0016 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0032 0.0309 0.0429
Echinococcus granulosus peptide allatostatin:somatostatin 0.0008 0.0024 0.0024
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0147 0.1704
Brugia malayi calpain family protein 1 0.0063 0.0679 0.0943
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0248 0.3319
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0147 0.07
Loa Loa (eye worm) hypothetical protein 0.0036 0.0352 0.0488
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.007 0.007
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0016 0.012 0.1629
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.007 0.007
Schistosoma mansoni biogenic amine (5HT) receptor 0.0008 0.0024 0.0024
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0024 0.0024
Loa Loa (eye worm) calpain 0.0019 0.0147 0.0205
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0729 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0024 0.0024
Echinococcus granulosus calpain 5 0.0019 0.0147 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.007 0.0097
Echinococcus multilocularis neuropeptide receptor A26 0.0008 0.0024 0.0024
Schistosoma mansoni cpg binding protein 0.0037 0.0365 0.0365
Brugia malayi calpain 5 0.0019 0.0147 0.0205
Brugia malayi hypothetical protein 0.0008 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Brugia malayi hypothetical protein 0.0008 0.0024 0.0033
Echinococcus multilocularis calpain 5 0.0019 0.0147 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.007 0.0097
Schistosoma mansoni neuropeptide F-like receptor 0.0008 0.0024 0.0024
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.008 0.0888 0.1233
Echinococcus multilocularis orexin receptor type 2 0.0008 0.0024 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0667 0.0667
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.0024 0.0024
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0016 0.012 0.1629
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0097
Echinococcus granulosus ferritin 0.0008 0.0022 0.0022
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0193 0.2823
Echinococcus multilocularis vesicular acetylcholine transporter 0.0437 0.5209 0.5209
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0024 0.0024
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0022 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Schistosoma mansoni hypothetical protein 0.0008 0.0024 0.0024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0024 0.0024
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0341 0.0474
Onchocerca volvulus 0.0035 0.0341 0.0442
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0621 0.0621
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0041 0.0065
Brugia malayi RNA binding protein 0.0062 0.0667 0.0926
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0248 0.251
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Trichomonas vaginalis set domain proteins, putative 0.0228 0.2683 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0008 0.0024 0.0024
Mycobacterium ulcerans aldehyde dehydrogenase 0.0058 0.0627 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0666 1
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0316 0.0439
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.007 0.007
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0008 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.007 0.007
Brugia malayi jmjC domain containing protein 0.0015 0.0108 0.015
Echinococcus granulosus smad 0.0008 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0015 0.0108 0.015
Echinococcus multilocularis fmrfamide receptor 0.0008 0.0024 0.0024
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.0024 0.0024
Mycobacterium ulcerans aldehyde dehydrogenase 0.0058 0.0627 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0019 0.0019
Loa Loa (eye worm) calpain family protein 1 0.0044 0.0454 0.063
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0016 0.012 0.1629
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0666 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.0147 0.07
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.007 0.0064
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0155 0.3765
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0108 0.0108
Plasmodium vivax SET domain protein, putative 0.0029 0.0278 1
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0016 0.012 0.1629
Brugia malayi ecdysteroid receptor 0.0012 0.007 0.0097
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Schistosoma mansoni histamine h1 receptor 0.0008 0.0024 0.0024
Echinococcus granulosus phd:f box containing protein 0.0015 0.0108 0.0108
Brugia malayi CXXC zinc finger family protein 0.0035 0.0341 0.0474
Schistosoma mansoni Smad4 0.0008 0.0019 0.0019
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.007 0.007
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.007 0.007
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0105 0.0105
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0008 0.0024 0.0024
Brugia malayi G protein-coupled receptor F59B2.13 0.0008 0.0024 0.0033
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0147 0.1704
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.012 0.1273
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0156
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0016 0.012 0.1629
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0016 0.012 0.1629
Leishmania major phosphopantetheinyl transferase-like protein 0.0022 0.0194 0.153
Brugia malayi RE15519p 0.0008 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0718 0.0718
Echinococcus granulosus lamin dm0 0.0033 0.0316 0.0316
Schistosoma mansoni biogenic amine receptor 0.0008 0.0024 0.0024
Schistosoma mansoni calpain (C02 family) 0.0019 0.0147 0.0147
Echinococcus multilocularis calpain family protein 1, d 0.0044 0.0454 0.0454
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0155 0.0517
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0108 0.0108
Brugia malayi AKH receptor 0.0008 0.0024 0.0033
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0008 0.0024 0.0024
Schistosoma mansoni neuropeptide receptor 0.0008 0.0024 0.0024
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0193 0.2823
Schistosoma mansoni aldehyde dehydrogenase 0.0058 0.0627 0.0627
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0019 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0278 0.0278
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.007 0.007
Brugia malayi sulfakinin receptor protein 0.0008 0.0024 0.0033
Brugia malayi jmjC domain containing protein 0.0015 0.0108 0.015
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0501 0.0696
Brugia malayi hypothetical protein 0.0008 0.0024 0.0033
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0016 0.012 0.1629
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.007 0.007
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0108 0.0108
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.007 0.0097
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0352 0.0352
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0318 0.0442
Echinococcus multilocularis allatostatin A receptor 0.0008 0.0024 0.0024
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0065 0.0065
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0147 0.07
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0155 0.0215
Echinococcus multilocularis neuropeptide Y receptor 0.0008 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0008 0.0024 0.0024
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0016 0.012 0.1629
Schistosoma mansoni ferritin light chain 0.0008 0.0022 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Schistosoma mansoni cpg binding protein 0.0035 0.0341 0.0341
Loa Loa (eye worm) cytochrome P450 0.0016 0.012 0.0167
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0008 0.0024 0.0024
Brugia malayi Melatonin receptor type 1A 0.0008 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0044 0.0454 0.063
Mycobacterium leprae putative cytochrome p450 0.0016 0.012 0.5737
Brugia malayi steroid hormone receptor 0.0012 0.007 0.0097
Echinococcus granulosus vesicular acetylcholine transporter 0.0437 0.5209 0.5209
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.1118 0.1118
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0016 0.012 0.1629
Schistosoma mansoni ferritin 0.0008 0.0022 0.0022
Brugia malayi hypothetical protein 0.0008 0.0024 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0024 0.0024
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0193 0.6472
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0022 0.0194 0.2839
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.007 0.007
Schistosoma mansoni ferritin 0.0008 0.0022 0.0022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0017 0.00000000036032
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.0024 0.0024
Schistosoma mansoni smad1 5 8 and 0.0008 0.0019 0.0019
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0193 0.0193
Echinococcus multilocularis neuropeptide receptor 0.0008 0.0024 0.0024
Echinococcus multilocularis neuropeptides capa receptor 0.0008 0.0024 0.0024
Trichomonas vaginalis ferritin, putative 0.0008 0.0022 0.0017
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0147 0.07
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0008 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0015 0.0105 0.0105
Echinococcus granulosus g protein coupled receptor 0.0008 0.0024 0.0024
Brugia malayi larval opioid receptor 0.0008 0.0024 0.0033
Echinococcus granulosus alpha 1A adrenergic receptor 0.0008 0.0024 0.0024
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.007 0.0064
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0097
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0015 0.0108 0.015
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0008 0.0024 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0024 0.0024
Echinococcus granulosus neuropeptide receptor 0.0008 0.0024 0.0024
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0008 0.0024 0.0024
Schistosoma mansoni biogenic amine (5HT) receptor 0.0008 0.0024 0.0024
Plasmodium vivax calpain, putative 0.0019 0.0147 0.4596
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0278 0.3487
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0666 0.9088
Loa Loa (eye worm) calpain 5 0.0019 0.0147 0.0205
Onchocerca volvulus 0.0044 0.0454 0.0599
Brugia malayi ORL1-like opioid receptor 0.0008 0.0024 0.0033
Mycobacterium leprae conserved hypothetical protein 0.0022 0.0194 1
Brugia malayi Dopamine receptor 0.0008 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0008 0.0024 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.007 0.0097
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.012 0.1273
Echinococcus multilocularis G-protein coupled receptor, putative 0.0008 0.0024 0.0024
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0147 0.1704
Echinococcus granulosus 7tm_1 domain containing protein 0.0008 0.0024 0.0024
Loa Loa (eye worm) calpain family protein 1 0.0063 0.0679 0.0943
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0147 0.0147
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0008 0.0024 0.0024
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0155 0.0837
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0147 0.1704
Loa Loa (eye worm) hypothetical protein 0.0063 0.0679 0.0943
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0155 0.0517
Schistosoma mansoni opsin-like receptor 0.0008 0.0024 0.0024
Echinococcus multilocularis g protein coupled receptor 0.0008 0.0024 0.0024
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.0147 0.1704
Schistosoma mansoni growth hormone secretagogue receptor 0.0008 0.0024 0.0024
Echinococcus multilocularis 0.0016 0.012 0.012
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0008 0.0024 0.0024
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0022 0.0194 0.2839
Schistosoma mansoni neuropeptide F-like receptor 0.0008 0.0024 0.0024
Echinococcus granulosus fmrfamide receptor 0.0008 0.0024 0.0024
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0008 0.0024 0.0024
Brugia malayi Smad1 0.0008 0.0019 0.0026
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.0024 0.0033
Echinococcus multilocularis geminin 0.0163 0.1891 0.1891
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0667 0.0926
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0352 0.4361
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0147 0.0147
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.2349 0.3263
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0024 0.0024
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0133 0.0185
Echinococcus multilocularis neuropeptides capa receptor 0.0008 0.0024 0.0024
Schistosoma mansoni DNA helicase recq1 0.0019 0.0155 0.0155
Brugia malayi neuropeptide F receptor 0.0008 0.0024 0.0033
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.007 0.007
Brugia malayi jmjC domain containing protein 0.006 0.0645 0.0895
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0155 0.0155
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0108 0.108
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.1118 0.1553
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0008 0.0024 0.0033
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0147 0.1704
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0065 0.0065
Echinococcus multilocularis serotonin receptor 0.0008 0.0024 0.0024
Schistosoma mansoni DNA helicase recq5 0.0019 0.0155 0.0155
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0016 0.012 0.1629
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0039 0.0039
Echinococcus granulosus L aminoadipate semialdehyde 0.008 0.0888 0.0888
Echinococcus multilocularis g-protein coupled receptor 0.0008 0.0024 0.0024
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0016 0.012 0.1629
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Brugia malayi jmjC domain containing protein 0.0058 0.0621 0.0862
Onchocerca volvulus 0.0012 0.007 0.0064
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.051 0.6092 0.6092
Echinococcus granulosus hypothetical protein 0.0008 0.0024 0.0024
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0065 0.009
Schistosoma mansoni hypothetical protein 0.0163 0.1891 0.1891
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0256 0.0256
Echinococcus multilocularis serotonin receptor 0.0008 0.0024 0.0024
Echinococcus granulosus allatostatin A receptor 0.0008 0.0024 0.0024
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0016 0.012 0.1629
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.008 0.0888 0.0888
Echinococcus granulosus geminin 0.0163 0.1891 0.1891
Schistosoma mansoni ferritin 0.0008 0.0022 0.0022
Loa Loa (eye worm) melatonin receptor type 1A 0.0008 0.0024 0.0033
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0016 0.012 0.1629
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0022 0.0194 0.2271
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0718 0.0718
Brugia malayi TAR-binding protein 0.0062 0.0667 0.0926
Onchocerca volvulus 0.0602 0.72 1
Brugia malayi nuclear receptor NHR-88 0.0012 0.007 0.0097
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0147 0.07
Brugia malayi calpain 7 0.0019 0.0147 0.0205
Echinococcus granulosus g protein coupled receptor 0.0008 0.0024 0.0024
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0193 0.9943
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0666 0.0666
Brugia malayi nuclear hormone receptor 0.0012 0.007 0.0097
Brugia malayi MH1 domain containing protein 0.0008 0.0019 0.0026
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0132 0.0132
Echinococcus granulosus calpain A 0.0019 0.0147 0.0147
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0008 0.0024 0.0024
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0016 0.012 0.1629
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0155 0.0155
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.007 0.007
Brugia malayi jmjC domain containing protein 0.0015 0.0108 0.015
Echinococcus granulosus neuropeptide receptor A26 0.0008 0.0024 0.0024
Schistosoma mansoni cytochrome P450 0.0016 0.012 0.012
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0016 0.012 0.1629
Loa Loa (eye worm) hypothetical protein 0.0033 0.0316 0.0439
Echinococcus granulosus neuropeptides capa receptor 0.0008 0.0024 0.0024
Brugia malayi hypothetical protein 0.0008 0.0024 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0667 0.0667
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0155 0.5468
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0133 0.0185
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0147 0.1704
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0147 0.07
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0058 0.0627 0.0627
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0278 0.0278
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0667 0.0926
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.007 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.007 0.0097
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0645 0.0645
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0024 0.0024
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0132 0.0132
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0352 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0105 0.0105
Echinococcus multilocularis sex peptide receptor 0.0008 0.0024 0.0024
Onchocerca volvulus 0.0033 0.0316 0.0407
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0008 0.0024 0.0024
Echinococcus multilocularis fmrfamide receptor 0.0008 0.0024 0.0024
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0008 0.0024 0.0033
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0008 0.0024 0.0024
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0155 0.0215
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0008 0.0024 0.0024
Brugia malayi Tachykinin-like peptides receptor 99D 0.0008 0.0024 0.0033
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0066 0.0718 0.0718
Schistosoma mansoni amine GPCR 0.0008 0.0024 0.0024
Onchocerca volvulus 0.0228 0.2683 0.3705
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0017 0.00000000036032
Brugia malayi Cytochrome P450 family protein 0.0027 0.0248 0.0345
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0352 0.0352
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0041 0.111
Schistosoma mansoni hypothetical protein 0.0033 0.0318 0.0318
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0666 0.2435
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0016 0.012 0.1629
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.007 0.0097
Echinococcus granulosus bloom syndrome protein 0.0019 0.0155 0.0155
Toxoplasma gondii cytochrome p450 superfamily protein 0.0016 0.012 0.1213
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0666 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0008 0.0024 0.0024
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0193 0.9943
Echinococcus granulosus dro:myosuppressin receptor 0.0008 0.0024 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0163 0.1891 0.1891
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0016 0.012 0.1629
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0022 0.0194 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0105 0.0146
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0621 0.0621
Brugia malayi MH1 domain containing protein 0.0008 0.0019 0.0026
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0248 0.0345
Entamoeba histolytica hypothetical protein 0.0022 0.0194 0.4992
Toxoplasma gondii exonuclease III APE 0.0022 0.0193 0.2257
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0352 0.0352
Brugia malayi vesicular acetylcholine transporter unc-17 0.0437 0.5209 0.7235
Echinococcus granulosus neuropeptide Y receptor 0.0008 0.0024 0.0024
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0016 0.012 0.1629
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.0024 0.0024
Brugia malayi Serotonin receptor 0.0008 0.0024 0.0033
Schistosoma mansoni ap endonuclease 0.0022 0.0193 0.0193
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0008 0.0024 0.0024
Brugia malayi hypothetical protein 0.0008 0.0024 0.0033
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0666 1
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0097
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0016 0.012 0.1629
Schistosoma mansoni smad1 5 8 and 0.0008 0.0019 0.0019
Schistosoma mansoni ferritin light chain 0.0008 0.0022 0.0022
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0016 0.012 0.1629
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0016 0.012 0.1629
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0108 0.0108
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0501 0.0696
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0108 0.0108
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.1118 0.1118
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0666 0.0666
Entamoeba histolytica recQ family DNA helicase 0.001 0.0041 0.0143
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0008 0.0024 0.0033
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0008 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0602 0.72 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0016 0.012 0.1629
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0024 0.0024
Schistosoma mansoni lamin 0.0033 0.0316 0.0316
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0016 0.012 0.1629
Schistosoma mansoni blooms syndrome DNA helicase 0.0009 0.0036 0.0036
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0063 0.0087
Brugia malayi Cytochrome P450 family protein 0.0027 0.0248 0.0345
Brugia malayi putative neuropeptide receptor 0.0008 0.0024 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0024 0.0024
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0063 0.0679 0.0679
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0193 0.0738
Echinococcus multilocularis cpg binding protein 0.0037 0.0365 0.0365
Brugia malayi cytochrome P450 0.0016 0.012 0.0167
Echinococcus multilocularis lamin dm0 0.0033 0.0316 0.0316
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0193 0.0659
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0019 0.0026
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0352 0.0352
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0024 0.0024
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0352 0.0352
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.007 0.007
Echinococcus granulosus GPCR family 2 0.0015 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0033 0.0318 0.0442
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.007 0.007
Echinococcus multilocularis expressed protein 0.0008 0.0022 0.0022
Trypanosoma brucei antigen, putative 0.0019 0.0147 0.07
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Echinococcus granulosus tar DNA binding protein 0.0062 0.0667 0.0667
Echinococcus multilocularis G protein coupled receptor 139 0.0008 0.0024 0.0024
Echinococcus multilocularis lamin 0.0033 0.0316 0.0316
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0112 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.007 0.0097
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0011 0.005 0.0069
Schistosoma mansoni nuclear hormone receptor 0.0012 0.007 0.007
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0016 0.012 0.1629
Schistosoma mansoni amine GPCR 0.0008 0.0024 0.0024
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0193 0.9886
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0147 0.1704
Brugia malayi Pre-SET motif family protein 0.0029 0.0278 0.0386
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.007 0.0097
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0146
Schistosoma mansoni apoferritin-2 0.0008 0.0022 0.0022
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0105 0.0146
Echinococcus multilocularis neuropeptide Y receptor 0.0008 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0097
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0146
Schistosoma mansoni amine GPCR 0.0008 0.0024 0.0024
Echinococcus multilocularis L aminoadipate semialdehyde 0.008 0.0888 0.0888
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0352 0.497
Schistosoma mansoni apoferritin-2 0.0008 0.0022 0.0022
Onchocerca volvulus 0.008 0.0888 0.1204

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 0.794328235 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 2.511886432 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 3.16227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 25.11886432 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (ADMET) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: Inhibitors of USP1/UAF1: Pilot qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504878] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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