Detailed information for compound 1342479

Basic information

Technical information
  • TDR Targets ID: 1342479
  • Name: 1-(1,2-dimethylindol-3-yl)-2-(4-methylpiperaz in-1-yl)ethane-1,2-dione
  • MW: 299.368 | Formula: C17H21N3O2
  • H donors: 0 H acceptors: 2 LogP: 1.55 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)C(=O)C(=O)c1c2ccccc2n(c1C)C
  • InChi: 1S/C17H21N3O2/c1-12-15(13-6-4-5-7-14(13)19(12)3)16(21)17(22)20-10-8-18(2)9-11-20/h4-7H,8-11H2,1-3H3
  • InChiKey: LUFQHHDIWUTTOJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(1,2-dimethyl-3-indolyl)-2-(4-methyl-1-piperazinyl)ethane-1,2-dione
  • MLS000684783
  • SMR000323286

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi histone deacetylase 1, putative 0.0525 0.1463 0.8503
Echinococcus granulosus histone deacetylase 6 0.0628 0.1754 0.4532
Schistosoma mansoni hypothetical protein 0.0169 0.0453 0.1171
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0214 0.0416
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0052 0.0043
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0078 0.0488
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0147 0.0856
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0033 0.0085
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0118 0.0683
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0017 0.0014
Mycobacterium ulcerans monoamine oxidase 0.0062 0.0148 0.0139
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0082 0.0205 0.053
Toxoplasma gondii histone deacetylase HDAC4 0.0259 0.0708 0.0708
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0117 0.0675
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0305 0.1769
Entamoeba histolytica hypothetical protein 0.0023 0.0039 0.0267
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0026 0.0149
Mycobacterium tuberculosis Probable reductase 0.0085 0.0214 0.0416
Echinococcus multilocularis histone deacetylase 7 0.0616 0.172 0.2479
Plasmodium falciparum thioredoxin reductase 0.0013 0.0009 0.0007
Schistosoma mansoni hypothetical protein 0.0011 0.0004 0.0009
Brugia malayi polk-prov protein 0.0054 0.0127 0.074
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0053 0.03
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0071 0.0174 0.1013
Loa Loa (eye worm) histone deacetylase 0.0616 0.172 1
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0036 0.0076 0.0426
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0056 0.0348
Echinococcus granulosus snurportin 1 0.0308 0.0847 0.2187
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0013 0.0013
Schistosoma mansoni acetylcholinesterase 0.0022 0.0036 0.0093
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0017 0.0091
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0078 0.0488
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0092 0.0092
Brugia malayi hypothetical protein 0.0119 0.0312 0.1812
Echinococcus multilocularis conserved hypothetical protein 0.0014 0.0013 0.0018
Onchocerca volvulus Protein patched homolog 0.0018 0.0024 0.0337
Brugia malayi hypothetical protein 0.0018 0.0024 0.0139
Echinococcus multilocularis exonuclease 1 0.001 0.0003 0.0003
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0029 0.0056 0.0056
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0028 0.0164
Trypanosoma brucei unspecified product 0.0063 0.015 0.0861
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.025 0.0681 0.0981
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0075 0.0186 0.1079
Schistosoma mansoni terminal deoxycytidyl transferase 0.0091 0.023 0.0595
Loa Loa (eye worm) hypothetical protein 0.0259 0.0708 0.4119
Echinococcus multilocularis tumor protein p63 0.0338 0.0932 0.1343
Brugia malayi Thioredoxin reductase 0.0037 0.0078 0.0454
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0052 0.0301
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0345 0.0891
Brugia malayi Patched family protein 0.0018 0.0024 0.0139
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0117 0.0305 0.1962
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0732 0.4733
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0214 0.0416
Schistosoma mansoni 3-dehydroquinate synthase 0.0126 0.0332 0.0857
Brugia malayi RNA, U transporter 1 0.0082 0.0206 0.1194
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0076 0.0474
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0148 0.0283
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0052 0.0288
Brugia malayi hypothetical protein 0.0029 0.0056 0.0326
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0062 0.0148 0.0198
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0001 0.0003
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0148 0.0383
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0028 0.0052 0.0043
Echinococcus multilocularis Niemann Pick C1 protein 0.0426 0.1181 0.1702
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0031 0.0044
Entamoeba histolytica deoxycytidyl transferase, putative 0.0091 0.023 0.1576
Echinococcus multilocularis histone deacetylase 3 0.0525 0.1463 0.2108
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0052 0.0301
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0325 0.0895 0.1732
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0161 0.0429 0.1109
Loa Loa (eye worm) Csnk2b protein 0.0036 0.0076 0.0439
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0003 0.0002
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0031 0.0044
Trypanosoma brucei cdc2-related kinase 1 0.0043 0.0095 0.0537
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0003 0.0019
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0007 0.0007
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0118 0.0118
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0019
Onchocerca volvulus 0.0049 0.0113 0.1595
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0082 0.0548
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0078 0.02
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0029 0.0056 0.0348
Brugia malayi ImpB/MucB/SamB family protein 0.0091 0.023 0.1339
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0132 0.0347 0.0897
Brugia malayi glutaminase DH11.1 0.0554 0.1545 0.8981
Plasmodium vivax chorismate synthase 0.3533 1 1
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0198 0.0536 0.0527
Mycobacterium ulcerans chorismate synthase 0.3533 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.024 0.0471
Loa Loa (eye worm) hypothetical protein 0.0064 0.0155 0.09
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Schistosoma mansoni hypothetical protein 0.0135 0.0357 0.0923
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0004 0.0005
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0076 0.0474
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0004 0.0009
Trichomonas vaginalis set domain proteins, putative 0.0236 0.0642 0.4145
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0009 0.0009
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0151 0.0217
Brugia malayi jmjC domain containing protein 0.0016 0.0017 0.0097
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0017 0.0024
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0126 0.0332 0.0657
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0031 0.0179
Giardia lamblia Hypothetical protein 0.0015 0.0015 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0056 0.0321
Loa Loa (eye worm) hypothetical protein 0.0128 0.0336 0.1951
Toxoplasma gondii ATPase, AAA family protein 0.0029 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Schistosoma mansoni casein kinase II beta subunit 0.0036 0.0076 0.0196
Brugia malayi Patched family protein 0.0018 0.0024 0.0139
Echinococcus granulosus intestinal type alkaline phosphatase 0.0161 0.0429 0.1109
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0017 0.0024
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0078 0.0446
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0028 0.0164
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0056 0.0348
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.025 0.0681 0.1759
Echinococcus multilocularis neuroligin 0.0022 0.0036 0.0052
Toxoplasma gondii hypothetical protein 0.0048 0.0109 0.0109
Brugia malayi Fli-1 protein 0.0228 0.0619 0.3601
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0055 0.0342
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0732 0.4733
Brugia malayi Calcitonin receptor-like protein seb-1 0.0198 0.0535 0.311
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0052 0.0043
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0015 0.0083
Brugia malayi Patched protein homolog 1 0.0018 0.0024 0.0139
Brugia malayi BRCA1-associated protein 2 containing protein 0.0012 0.0007 0.0039
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0026 0.0149
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0148 0.0283
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0031 0.008
Trichomonas vaginalis spcc417.12 protein, putative 0.0022 0.0036 0.0217
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.023 0.0594
Brugia malayi TAR-binding protein 0.0131 0.0345 0.2003
Loa Loa (eye worm) hypothetical protein 0.0116 0.0302 0.1755
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0003 0.0002
Brugia malayi Patched family protein 0.0018 0.0024 0.0139
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0028 0.0052 0.0087
Loa Loa (eye worm) oxidoreductase 0.0028 0.0052 0.0301
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0015 0.0015 0.0013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0198 0.0535 0.311
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0325 0.0895 0.0895
Leishmania major GTP-binding protein, putative 0.0021 0.0033 0.0177
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0015 0.0015 0.0039
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0015 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0031 0.0179
Brugia malayi CHE-14 protein 0.0128 0.0336 0.1951
Treponema pallidum DNA ligase (lig) 0.0029 0.0056 0.1031
Trypanosoma brucei DNA polymerase IV, putative 0.0111 0.0287 0.1654
Trichomonas vaginalis histone deacetylase, putative 0.0525 0.1463 0.9468
Loa Loa (eye worm) hypothetical protein 0.0094 0.0241 0.1399
Giardia lamblia Casein kinase II beta chain 0.0036 0.0076 0.0501
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0052 0.0296
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0022 0.0036 0.0052
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0241 0.0232
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.001 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0071 0.0174 0.1013
Echinococcus multilocularis cyclin dependent kinase 1 0.0043 0.0095 0.0136
Echinococcus granulosus histone deacetylase 7 0.0616 0.172 0.4444
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0015 0.0015 0.0039
Entamoeba histolytica cell division protein kinase 2, putative 0.0043 0.0095 0.0648
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.0471 0.665
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0198 0.0536 0.0527
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0076 0.0474
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0031 0.008
Brugia malayi Carboxylesterase family protein 0.0132 0.0347 0.2019
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0031 0.0433
Echinococcus granulosus acetylcholinesterase 0.0132 0.0347 0.0897
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.001 0.0051
Trypanosoma cruzi histone deacetylase, putative 0.0616 0.172 1
Onchocerca volvulus 0.0028 0.0052 0.0731
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0031 0.0044
Loa Loa (eye worm) carboxylesterase 0.0022 0.0036 0.0209
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0078 0.0454
Entamoeba histolytica acyl-CoA synthetase, putative 0.0095 0.0243 0.1658
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0031 0.0179
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0214 0.0416
Brugia malayi AMP-binding enzyme family protein 0.0095 0.0243 0.1409
Echinococcus granulosus acetylcholinesterase 0.0132 0.0347 0.0897
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0031 0.008
Plasmodium vivax patched family protein, putative 0.0018 0.0024 0.0024
Schistosoma mansoni exonuclease 0.001 0.0003 0.0006
Brugia malayi Patched related family protein 4 0.0018 0.0024 0.0139
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0015 0.0083
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0268 0.0732 0.4258
Trypanosoma brucei DNA polymerase IV, putative 0.0117 0.0305 0.1762
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0078 0.02
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0062 0.0148 0.0383
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0052 0.0296
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0241 0.0241
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0031 0.0079
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0372 0.2149
Mycobacterium leprae Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). 0.1742 0.4917 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.0052 0.0134
Loa Loa (eye worm) hypothetical protein 0.0029 0.0056 0.0326
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0028 0.0073
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.0248 0.0676 0.1746
Mycobacterium tuberculosis Conserved hypothetical protein 0.0091 0.023 0.0451
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0471 0.3039
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0082 0.0564
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.0816 0.4739
Echinococcus multilocularis para nitrobenzyl esterase 0.0022 0.0036 0.0052
Echinococcus granulosus replication factor c subunit 1 0.0029 0.0056 0.0145
Loa Loa (eye worm) hypothetical protein 0.015 0.0397 0.2309
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.024 0.0471
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0039 0.0237
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0305 0.1769
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0053 0.03
Echinococcus granulosus exonuclease 1 0.001 0.0003 0.0006
Onchocerca volvulus 0.0022 0.0036 0.0507
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0015 0.0015 0.0022
Brugia malayi jmjC domain containing protein 0.0016 0.0017 0.0097
Echinococcus multilocularis casein kinase ii subunit beta 0.0036 0.0076 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0031 0.0179
Brugia malayi Importin beta-1 subunit 0.0029 0.0055 0.0317
Loa Loa (eye worm) hypothetical protein 0.0138 0.0363 0.2111
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0009 0.0048
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0026 0.0142
Brugia malayi Ets-domain containing protein 0.0075 0.0186 0.1079
Toxoplasma gondii patched family protein 0.0018 0.0024 0.0024
Schistosoma mansoni histone deacetylase 1 2 3 0.0259 0.0708 0.183
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0118 0.0683
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0278 0.1604
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0028 0.0052 0.0043
Onchocerca volvulus 0.0018 0.0024 0.0337
Brugia malayi jmjC domain containing protein 0.0058 0.0138 0.0801
Echinococcus granulosus tumor protein p63 0.0338 0.0932 0.2408
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0091 0.023 0.0332
Mycobacterium tuberculosis Carboxylesterase LipT 0.0022 0.0036 0.0054
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0055 0.0342
Trypanosoma brucei DNA polymerase eta, putative 0.0116 0.0302 0.1744
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0036 0.0076 0.0076
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0009 0.0048
Trypanosoma cruzi DNA repair protein RAD2, putative 0.001 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Echinococcus granulosus Niemann Pick C1 protein 0.0298 0.0818 0.2114
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.002
Onchocerca volvulus 0.0236 0.0642 0.9058
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0014 0.0013 0.001
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0298 0.0818 0.5595
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0125 0.0328 0.0847
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.006 0.0155
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0241 0.0238
Entamoeba histolytica histone deacetylase, putative 0.0525 0.1463 1
Loa Loa (eye worm) hypothetical protein 0.0525 0.1463 0.8504
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0033 0.0191
Echinococcus granulosus Niemann Pick C1 protein 0.0426 0.1181 0.3052
Schistosoma mansoni thyroid hormone receptor 0.002 0.0031 0.008
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0031 0.0179
Plasmodium falciparum flap endonuclease 1 0.0052 0.0119 0.0117
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0036 0.0076 0.0426
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0082 0.0205 0.1193
Brugia malayi nuclear receptor RXR 0.0011 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0019
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0052 0.0087
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0027 0.0157
Schistosoma mansoni patched 1 0.0128 0.0336 0.0867
Plasmodium falciparum importin beta, putative 0.0029 0.0055 0.0052
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.0816 0.4734
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.001 0.0003 0.0003
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0028 0.0052 0.0043
Trichomonas vaginalis DNA polymerase eta, putative 0.0117 0.0305 0.1962
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0043 0.0095 0.0537
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0278 0.0269
Brugia malayi hypothetical protein 0.0037 0.0078 0.0454
Brugia malayi hypothetical protein 0.0062 0.0148 0.0861
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0214 0.0416
Schistosoma mansoni DNA polymerase eta 0.0116 0.0302 0.078
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0004 0.0009
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0062 0.0148 0.0146
Brugia malayi phosphofructokinase 0.0108 0.0278 0.1616
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0209
Trichomonas vaginalis histone deacetylase, putative 0.0525 0.1463 0.9468
Loa Loa (eye worm) hypothetical protein 0.0198 0.0535 0.311
Loa Loa (eye worm) XPG I-region family protein 0.001 0.0003 0.0014
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0138 0.0199
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0028 0.0026
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0095 0.0243 0.0233
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0031 0.008
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0076 0.0474
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0139 0.0806
Entamoeba histolytica hypothetical protein 0.0037 0.0078 0.0534
Brugia malayi hypothetical protein 0.0018 0.0024 0.0139
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Entamoeba histolytica Ran family GTPase 0.0021 0.0033 0.0225
Echinococcus granulosus phd:f box containing protein 0.0016 0.0017 0.0043
Brugia malayi Carboxylesterase family protein 0.0022 0.0036 0.0209
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0052 0.0119 0.0688
Brugia malayi protein C24B5.3 0.0018 0.0024 0.0139
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0062 0.0148 0.0139
Brugia malayi Patched family protein 0.0018 0.0024 0.0139
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0118 0.0118
Brugia malayi Patched family protein 0.0018 0.0024 0.0139
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0039 0.0237
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0161 0.0429 0.0619
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.001 0.0051
Brugia malayi protein C24B5.3 0.0018 0.0024 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0051
Onchocerca volvulus 0.0028 0.0052 0.0731
Brugia malayi Histone deacetylase family protein 0.0616 0.172 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0052 0.0288
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0052 0.0052
Echinococcus multilocularis dna polymerase eta 0.0116 0.0302 0.0435
Loa Loa (eye worm) acetylcholinesterase 1 0.0132 0.0347 0.2019
Echinococcus granulosus lysine specific histone demethylase 1A 0.0062 0.0148 0.0382
Toxoplasma gondii exonuclease III APE 0.0019 0.0026 0.0026
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0055 0.1012
Brugia malayi Muscleblind-like protein 0.0599 0.1673 0.9725
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0164
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0095 0.0243 0.0233
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0026 0.0038
Echinococcus multilocularis muscleblind protein 0.0599 0.1673 0.2411
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0052 0.0043
Loa Loa (eye worm) hypothetical protein 0.0071 0.0174 0.1013
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0278 0.0401
Trichomonas vaginalis conserved hypothetical protein 0.0128 0.0336 0.216
Schistosoma mansoni hypothetical protein 0.0123 0.0323 0.0833
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Brugia malayi jmjC domain containing protein 0.0062 0.0147 0.0856
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0078 0.0201
Plasmodium vivax JmjC domain containing protein 0.0016 0.0017 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0305 0.1762
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0003 0.0002
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0095 0.0243 0.0233
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0732 0.4733
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0095 0.0243 0.0392
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0052 0.0087
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0031 0.0044
Trypanosoma cruzi histone deacetylase, putative 0.0616 0.172 1
Trypanosoma cruzi cdc2-related kinase 3 0.0043 0.0095 0.0545
Brugia malayi Probable ClpP-like protease 0.0094 0.0241 0.1399
Loa Loa (eye worm) TAR-binding protein 0.0131 0.0345 0.2003
Schistosoma mansoni ets-related 0.0228 0.0619 0.16
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0091 0.023 0.0595
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.0816 0.4739
Brugia malayi jmjC domain containing protein 0.0016 0.0017 0.0097
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0243 0.0233
Echinococcus multilocularis flap endonuclease 1 0.0052 0.0119 0.0172
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.0076 0.0434
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0076 0.0474
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0028 0.0041
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.024 0.0471
Chlamydia trachomatis protoporphyrinogen oxidase 0.0062 0.0148 0.0139
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0051
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.0036 0.0054
Trypanosoma cruzi histone deacetylase, putative 0.0259 0.0708 0.4115
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0031 0.0179
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0043 0.0095 0.055
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.023 0.1337
Schistosoma mansoni nuclear hormone receptor 0.002 0.0031 0.008
Giardia lamblia Histone deacetylase 0.0525 0.1463 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0053 0.0138
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0015 0.0088
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.006 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0003 0.0008
Leishmania major importin beta-1 subunit, putative 0.0023 0.0039 0.0213
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0471 0.3039
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0031 0.0079
Schistosoma mansoni BC026374 protein (S09 family) 0.0022 0.0036 0.0093
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0062 0.0148 0.0213
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0009 0.004
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0052 0.0087
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0053 0.0292
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0006
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0027 0.007
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0278 0.0465
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0241 0.0232
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0031 0.0179
Schistosoma mansoni apoptosis regulator bax 0.0082 0.0205 0.053
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.0345 0.2003
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0052 0.0043
Plasmodium vivax flap endonuclease 1, putative 0.0052 0.0119 0.0119
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0012 0.0007 0.0033
Schistosoma mansoni DNA helicase recq1 0.002 0.0028 0.0073
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0009 0.0009
Loa Loa (eye worm) carboxylesterase 0.0022 0.0036 0.0209
Mycobacterium ulcerans glutaminase 0.0554 0.1545 0.1537
Loa Loa (eye worm) hypothetical protein 0.0062 0.0148 0.0861
Schistosoma mansoni ets 0.0011 0.0004 0.0009
Schistosoma mansoni histone deacetylase 4 5 0.0616 0.172 0.4444
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0009 0.0013
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0055 0.0303
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0052 0.0119 0.068
Brugia malayi topoisomerase 0.0029 0.0056 0.0326
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0325 0.0895 0.0886
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0278 0.1901
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0028 0.0168
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0816 0.2288 0.4644
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0055 0.0342
Schistosoma mansoni histone deacetylase 4 5 0.0616 0.172 0.4444
Echinococcus multilocularis acetylcholinesterase 0.0132 0.0347 0.05
Echinococcus multilocularis dna polymerase kappa 0.0117 0.0305 0.044
Loa Loa (eye worm) hypothetical protein 0.0599 0.1673 0.9725
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0179
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0014
Leishmania major 4-coumarate:coa ligase-like protein 0.0095 0.0243 0.1398
Echinococcus granulosus flap endonuclease GEN 1 0.001 0.0003 0.0006
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0126 0.0332 0.0657
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0052 0.0043
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0029 0.0056 0.0321
Toxoplasma gondii histone deacetylase HDAC5 0.0259 0.0708 0.0708
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0082 0.0205 0.0296
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0097
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0278 0.5179
Loa Loa (eye worm) hypothetical protein 0.0029 0.0056 0.0326
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0017 0.0043
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0017 0.0024
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.025 0.0681 0.3959
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0078 0.0449
Mycobacterium ulcerans DNA polymerase IV 0.0117 0.0305 0.0296
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0092 0.0583
Echinococcus multilocularis nibrin 0.0029 0.0056 0.0081
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0026 0.0066
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0004 0.002
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0178 0.0477 0.277
Schistosoma mansoni DNA helicase recq5 0.002 0.0028 0.0073
Schistosoma mansoni hypothetical protein 0.0169 0.0453 0.1171
Trypanosoma cruzi DNA polymerase eta, putative 0.0116 0.0302 0.1751
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0178 0.0478 0.2769
Echinococcus multilocularis dual specificity 0.0178 0.0478 0.0689
Echinococcus granulosus histone deacetylase 6 0.0616 0.172 0.4444
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0055 0.0361
Brugia malayi Ets-domain containing protein 0.0075 0.0186 0.1079
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0073
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0009 0.0046
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0028 0.0052 0.0087
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0009 0.004
Trichomonas vaginalis brca1-associated protein, putative 0.0012 0.0007 0.0028
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0003 0.0009
Giardia lamblia Casein kinase II beta chain 0.0011 0.0003 0.0002
Brugia malayi latrophilin 2 splice variant baaae 0.0135 0.0357 0.2075
Onchocerca volvulus 0.0062 0.0148 0.209
Loa Loa (eye worm) hypothetical protein 0.0042 0.0091 0.0527
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0241 0.4395
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0017 0.0017
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0036 0.0093
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0028 0.0168
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0095 0.0243 0.0475
Schistosoma mansoni hypothetical protein 0.0063 0.0151 0.0389
Echinococcus multilocularis sterol regulatory element binding protein 0.0128 0.0336 0.0484
Loa Loa (eye worm) RecQ helicase 0.002 0.0028 0.0164
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0017 0.0024
Trypanosoma cruzi cdc2-related kinase 1 0.0043 0.0095 0.0545
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0151 0.0875
Loa Loa (eye worm) hypothetical protein 0.0029 0.0056 0.0326
Brugia malayi Carboxylesterase family protein 0.0022 0.0036 0.0209
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0015 0.0015 0.0039
Plasmodium falciparum casein kinase II beta chain 0.0036 0.0076 0.0073
Trichomonas vaginalis replication factor C large subunit, putative 0.0029 0.0056 0.0348
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0026 0.0134
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.038 0.2208
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0174 0.0165
Entamoeba histolytica protein kinase, putative 0.0178 0.0478 0.3269
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0062 0.0148 0.0146
Trypanosoma brucei DNA damage repair protein, putative 0.0028 0.0053 0.0292
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0003 0.0002
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0028 0.0177
Onchocerca volvulus 0.0029 0.0056 0.0792
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0028 0.0053 0.0053
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0022 0.0036 0.0093
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0028 0.0028
Echinococcus granulosus importin subunit beta 1 0.0029 0.0055 0.0141
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0003 0.0008
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0017 0.0097
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0033 0.0191
Plasmodium vivax histone deacetylase, putative 0.0259 0.0708 0.0708
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0052 0.0043
Schistosoma mansoni thyroid hormone receptor 0.002 0.0031 0.008
Entamoeba histolytica hypothetical protein 0.0037 0.0078 0.0534
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0015 0.0015 0.0039
Leishmania major 4-coumarate:coa ligase-like protein 0.0095 0.0243 0.1398
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0031 0.008
Onchocerca volvulus 0.0022 0.0036 0.0507
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0308 0.179
Brugia malayi Flap endonuclease-1 0.0052 0.0119 0.0693
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0031 0.0079
Echinococcus multilocularis BC026374 protein (S09 family) 0.0022 0.0036 0.0052
Plasmodium falciparum glutathione reductase 0.0037 0.0078 0.0076
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0017 0.0091
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.001 0.0051
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0012 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0062 0.0148 0.0861
Echinococcus granulosus dna polymerase kappa 0.0117 0.0305 0.0788
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0372 0.2156
Toxoplasma gondii patched family protein 0.0018 0.0024 0.0024
Echinococcus multilocularis cyclin dependent kinase 5 0.0043 0.0095 0.0136
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0345 0.0891
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0015 0.0088
Echinococcus granulosus muscleblind protein 0.0599 0.1673 0.4322
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.038 0.0981
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.023 0.0331
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0028 0.0052 0.0043
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0178 0.0477 0.6726
Plasmodium falciparum chorismate synthase 0.3533 1 1
Trypanosoma cruzi cdc2-related kinase 1 0.0043 0.0095 0.0545
Leishmania major hypothetical protein, conserved 0.0012 0.0007 0.0025
Schistosoma mansoni hypothetical protein 0.0063 0.0151 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0031 0.0179
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0052 0.0087
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0031 0.0044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0163 0.0314
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0214 0.0416
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0017 0.0044
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0278 0.1616
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0015 0.0015 0.0083
Echinococcus granulosus carboxylesterase 5A 0.0132 0.0347 0.0897
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0178 0.0478 0.2779
Loa Loa (eye worm) casein kinase II 0.0011 0.0003 0.0015
Schistosoma mansoni cpg binding protein 0.0062 0.0148 0.0383
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0003 0.0008
Brugia malayi Carboxylesterase family protein 0.0022 0.0036 0.0209
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0052 0.0288
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0305 0.1762
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0078 0.0112
Trichomonas vaginalis histone deacetylase, putative 0.0525 0.1463 0.9468
Onchocerca volvulus 0.0031 0.006 0.0848
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0028 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0056 0.0348
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0013 0.0013
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0004 0.0009
Schistosoma mansoni cpg binding protein 0.0062 0.0148 0.0383
Loa Loa (eye worm) hypothetical protein 0.0135 0.0357 0.2075
Plasmodium vivax DNA repair protein REV1, putative 0.0028 0.0053 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0078 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0051
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0015 0.0015 0.0088
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0268 0.0732 0.4258
Brugia malayi Patched family protein 0.0018 0.0024 0.0139
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0097
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0029 0.0056 0.0348
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0043 0.0095 0.0537
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0113 0.0292
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0241 0.0232
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0028 0.0052 0.0043
Echinococcus multilocularis BRCA1 associated protein 0.0012 0.0007 0.001
Trypanosoma brucei histone deacetylase 4 0.0616 0.172 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0312 0.1812
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0078 0.0078
Entamoeba histolytica hypothetical protein 0.0178 0.0478 0.3269
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0017 0.0043
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0015 0.0015 0.0074
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0029 0.0056 0.0326
Trichomonas vaginalis helicase, putative 0.0013 0.001 0.0051
Schistosoma mansoni elf1 0.0011 0.0004 0.0009
Schistosoma mansoni brca1-associated protein (brap2) 0.0012 0.0007 0.0018
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0029 0.0056 0.0009
Giardia lamblia Kinase, CMGC CDK 0.0043 0.0095 0.0632
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0031 0.0179
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0003 0.0002
Giardia lamblia Kinase, CMGC CDK 0.0043 0.0095 0.0632
Echinococcus multilocularis protein C ets 2 0.0011 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0368 0.1018 0.592
Schistosoma mansoni ets-related 0.0011 0.0004 0.0009
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0029 0.0056 0.0313
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0163 0.0314
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.008 0.0115
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0241 0.0232
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0052 0.0301
Leishmania major DNA polymerase eta, putative 0.0053 0.0124 0.0709
Echinococcus granulosus alkaline phosphatase 0.0161 0.0429 0.1109
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0013 0.0013
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0147 0.0381
Loa Loa (eye worm) hypothetical protein 0.0356 0.0984 0.5722
Schistosoma mansoni hypothetical protein 0.0011 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0056 0.0326
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0278 0.1901
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0076 0.0517
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0052 0.032
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0138 0.0199
Onchocerca volvulus 0.0018 0.0024 0.0337
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0078 0.0531
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0012 0.0007 0.0025
Schistosoma mansoni hypothetical protein 0.0014 0.0013 0.0033
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0179
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0015 0.0015 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0031 0.0179
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Brugia malayi Patched family protein 0.0018 0.0024 0.0139
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0278 0.1787
Loa Loa (eye worm) hypothetical protein 0.0256 0.07 0.4067
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0003 0.0002
Entamoeba histolytica hypothetical protein 0.0029 0.0056 0.0384
Schistosoma mansoni histone deacetylase 0.0525 0.1463 0.3779
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0009 0.004
Leishmania major histone deacetylase, putative 0.0616 0.172 1
Schistosoma mansoni brca1-associated protein (brap2) 0.0012 0.0007 0.0018
Schistosoma mansoni hypothetical protein 0.0123 0.0323 0.0833
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0278 0.1787
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.0052 0.0134
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0147 0.0381
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0305 0.1762
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0052 0.0119 0.068
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0091 0.0524
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0178 0.0478 0.2775
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0015 0.0088
Trypanosoma cruzi cdc2-related kinase 3 0.0043 0.0095 0.0545
Brugia malayi Patched family protein 0.0018 0.0024 0.0139
Loa Loa (eye worm) hypothetical protein 0.0062 0.0148 0.0861
Giardia lamblia DINP protein human, muc B family 0.0097 0.0249 0.1688
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.023 0.1337
Echinococcus granulosus casein kinase ii subunit beta 0.0036 0.0076 0.0195
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.025 0.0681 0.1759
Brugia malayi transcription factor E74 isoform 0.0011 0.0004 0.002
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0082 0.0205 0.0296
Mycobacterium ulcerans hypothetical protein 0.0095 0.0243 0.0233
Loa Loa (eye worm) hypothetical protein 0.0054 0.0127 0.074
Plasmodium vivax acyl-CoA synthetase, putative 0.0071 0.0174 0.0174
Leishmania major trypanothione reductase 0.0037 0.0078 0.0441
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0028 0.0028
Echinococcus multilocularis snurportin 1 0.0308 0.0847 0.122
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0498 0.3213
Entamoeba histolytica recQ family helicase, putative 0.002 0.0028 0.0194
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0471 0.3039
Echinococcus multilocularis bloom syndrome protein 0.002 0.0028 0.0041
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0151 0.0217
Loa Loa (eye worm) patched family protein 0.0018 0.0024 0.0139
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0151 0.0389
Trypanosoma cruzi DNA repair protein RAD2, putative 0.001 0.0003 0.0008
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0151 0.0875
Trichomonas vaginalis BRCA1-associated protein, putative 0.0012 0.0007 0.0028
Schistosoma mansoni neuroligin 3 (S09 family) 0.0022 0.0036 0.0093
Mycobacterium tuberculosis Conserved hypothetical protein 0.0062 0.0148 0.0283
Brugia malayi Patched family protein 0.0018 0.0024 0.0139
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0062 0.0148 0.0383
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.0076 0.0076
Plasmodium falciparum glutathione reductase 0.0013 0.0009 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0095 0.0243 0.1409
Brugia malayi RE40412p 0.0014 0.0013 0.0073
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0012 0.0007 0.0033
Schistosoma mansoni hypothetical protein 0.0063 0.0151 0.0389
Schistosoma mansoni hypothetical protein 0.0833 0.2337 0.6039
Loa Loa (eye worm) patched family protein 0.0018 0.0024 0.0139
Leishmania major histone deacetylase, putative 0.0616 0.172 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0033 0.0185
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0009 0.0007
Plasmodium vivax histone deacetylase, putative 0.0616 0.172 0.172
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.0234 0.0636 0.1643
Leishmania major DNA polymerase kappa, putative 0.0028 0.0053 0.0292
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0209
Giardia lamblia Flap structure-specific endonuclease 0.0052 0.0119 0.08
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0092 0.0583
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0076 0.0474
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0198 0.0535 0.311
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0209
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0033 0.0209
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0243 0.0233
Echinococcus granulosus BRCA1 associated protein 0.0012 0.0007 0.0017
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0076 0.0474
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0179
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0062 0.0148 0.0148
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0099 0.0255 0.148
Chlamydia trachomatis DNA ligase 0.0029 0.0056 0.0047
Brugia malayi Protein kinase domain containing protein 0.0178 0.0478 0.2779
Brugia malayi steroid hormone receptor 0.002 0.0031 0.0179
Brugia malayi Myosin head containing protein 0.0018 0.0024 0.0139
Echinococcus granulosus BC026374 protein S09 family 0.0022 0.0036 0.0093
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0241 0.0347
Toxoplasma gondii ck2 beta subunit 0.0036 0.0076 0.0076
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0055 0.0055
Brugia malayi hypothetical protein 0.0029 0.0056 0.0326
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0028 0.0052 0.0049
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0078 0.0446
Brugia malayi Patched family protein 0.0018 0.0024 0.0139
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.001 0.0051
Mycobacterium tuberculosis Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) 0.1742 0.4917 1
Brugia malayi glutathione reductase 0.0037 0.0078 0.0454
Leishmania major hypothetical protein, conserved 0.0016 0.0017 0.0083
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0029 0.0056 0.0326
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0043 0.0095 0.055
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0198 0.0536 1
Onchocerca volvulus 0.0028 0.0052 0.0731
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0009 0.0048
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0028 0.0159
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0053 0.0292
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0053 0.0124 0.0124
Echinococcus multilocularis expressed conserved protein 0.028 0.0767 0.1105
Brugia malayi DKFZp564C0469 protein 0.0029 0.0056 0.0326
Brugia malayi hypothetical protein 0.0033 0.0067 0.0388
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0055 0.0342
Echinococcus multilocularis protoporphyrinogen oxidase 0.0062 0.0148 0.0213
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0078 0.0451
Echinococcus granulosus tar DNA binding protein 0.0131 0.0345 0.089
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0003 0.0019
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0241 0.4481
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0241 0.0241
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0031 0.008
Toxoplasma gondii histone deacetylase HDAC1 0.0616 0.172 0.172
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0043 0.0095 0.055
Onchocerca volvulus 0.002 0.0031 0.0433
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.006 0.0155
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0179
Echinococcus multilocularis flap endonuclease GEN 1 0.001 0.0003 0.0003
Brugia malayi Pax transcription activation domain interacting protein 0.0029 0.0056 0.0326
Leishmania major histone deacetylase, putative 0.0525 0.1463 0.8501
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0372 0.2149
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.0012 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0084 0.021 0.0543
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0078 0.0202
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Mycobacterium ulcerans oxidoreductase 0.0062 0.0148 0.0139
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0138 0.0356
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0118 0.0116
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0019
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0026 0.0037
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0009 0.0048
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0243 0.0233
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0003 0.0002
Onchocerca volvulus 0.0028 0.0052 0.0731
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0004 0.002
Brugia malayi SWIRM domain containing protein 0.0062 0.0148 0.0861
Loa Loa (eye worm) hypothetical protein 0.0119 0.0312 0.1812
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0179
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0015 0.0015 0.0015
Loa Loa (eye worm) fli-1 protein 0.0228 0.0619 0.3601
Toxoplasma gondii propionate-CoA ligase 0.0028 0.0052 0.0052
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0009 0.0044
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0126 0.0332 0.0323
Plasmodium vivax acetyl-CoA synthetase, putative 0.0028 0.0052 0.0052
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0015 0.0015 0.0039
Schistosoma mansoni ran 0.0021 0.0033 0.0085
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0036 0.0093
Schistosoma mansoni ran 0.0021 0.0033 0.0085
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0078 0.0112
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0022 0.0036 0.0217
Trypanosoma brucei DNA damage repair protein, putative 0.0028 0.0053 0.0292
Loa Loa (eye worm) patched family protein 0.0018 0.0024 0.0139
Loa Loa (eye worm) hypothetical protein 0.0069 0.0168 0.0974
Giardia lamblia Replication factor C, subunit 1 0.0029 0.0056 0.0368
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0078 0.0438
Schistosoma mansoni histone deacetylase hda2 0.0259 0.0708 0.183
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0119 0.0309 0.0798
Echinococcus granulosus Protein patched homolog 1 0.0128 0.0336 0.0867
Echinococcus multilocularis ets variant gene 4 0.0011 0.0004 0.0005
Schistosoma mansoni importin beta-1 0.0029 0.0055 0.0141
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0305 0.1762
Mycobacterium ulcerans dehydrogenase 0.0062 0.0148 0.0139
Onchocerca volvulus 0.0022 0.0036 0.0507
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0078 0.0515
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0029 0.0056 0.0384
Schistosoma mansoni DNA polymerase IV / kappa 0.0028 0.0053 0.0136
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0345 0.0891
Leishmania major DNA polymerase eta, putative 0.0116 0.0302 0.1744
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0076 0.0474
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0012 0.0007 0.0039
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0278 0.1787
Echinococcus multilocularis cyclin dependent kinase 1 0.0043 0.0095 0.0136
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0009 0.004
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0033 0.0177
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0031 0.0079
Brugia malayi hypothetical protein 0.0018 0.0024 0.0139
Onchocerca volvulus Histone deacetylase 10 homolog 0.0259 0.0708 1
Entamoeba histolytica recQ family DNA helicase 0.001 0.0001 0.0007
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.0052 0.0075
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.0368 0.0952
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0012 0.0007 0.0033
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0278 0.0718
Plasmodium vivax protein kinase Crk2 0.0043 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0019
Toxoplasma gondii XPG N-terminal domain-containing protein 0.001 0.0003 0.0003
Trichomonas vaginalis ran, putative 0.0021 0.0033 0.0197
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0305 0.1762
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0015 0.0083
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0028 0.0052 0.0043
Plasmodium vivax DNA repair protein RAD2, putative 0.001 0.0003 0.0003
Trypanosoma brucei histone deacetylase 2 0.0259 0.0708 0.411
Plasmodium vivax replication factor C subunit 1, putative 0.0029 0.0056 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.0478 0.1235
Trichomonas vaginalis histone deacetylase, putative 0.0525 0.1463 0.9468
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0017 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0031 0.0179
Brugia malayi ecdysteroid receptor 0.002 0.0031 0.0179
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0241 0.0388
Loa Loa (eye worm) hypothetical protein 0.0095 0.0243 0.1409
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0091 0.023 0.1339
Brugia malayi Patched family protein 0.0018 0.0024 0.0139
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.0234 0.0636 0.0916
Echinococcus granulosus histone deacetylase 8 0.0259 0.0708 0.183
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0147 0.038
Echinococcus multilocularis histone deacetylase 6 0.0616 0.172 0.2479
Mycobacterium ulcerans carboxylesterase, LipT 0.0022 0.0036 0.0027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0009 0.0048
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0095 0.0598
Leishmania major hypothetical protein, conserved 0.0051 0.0118 0.0675
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Toxoplasma gondii histone deacetylase HDAC3 0.0525 0.1463 0.1463
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0039 0.0237
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0017 0.0043
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0303 0.0831 0.2148
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0028 0.0052 0.0288
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.0052 0.0301
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0076 0.0517
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.006 0.006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0031 0.0079
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0052 0.0296
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0026 0.0148
Echinococcus multilocularis protein patched 0.0128 0.0336 0.0484
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0028 0.0073
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0325 0.0895 0.0886
Mycobacterium ulcerans acetyl-CoA synthetase 0.0028 0.0052 0.0043
Echinococcus multilocularis histone deacetylase 6 0.0616 0.172 0.2479
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0118 0.0675
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0071 0.0174 0.0165
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0038 0.0055
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0498 0.3213
Echinococcus granulosus DNA repair protein complementing XP G cells 0.001 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0179
Schistosoma mansoni amine oxidase 0.0062 0.0148 0.0383
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0052 0.0288
Brugia malayi XPG I-region family protein 0.001 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0056 0.0326
Brugia malayi Patched family protein 0.0018 0.0024 0.0139
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0015 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0178 0.0478 0.2775
Echinococcus granulosus dna polymerase eta 0.0116 0.0302 0.078
Plasmodium vivax importin-beta 2, putative 0.0029 0.0055 0.0055
Onchocerca volvulus 0.0014 0.0013 0.0177
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0732 0.4733
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0031 0.0433
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0031 0.0179
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0878 0.2464 0.2457
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0055 0.0342
Brugia malayi MH2 domain containing protein 0.0118 0.0308 0.179
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0026 0.0153
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0471 0.3039
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0014 0.0013 0.001
Schistosoma mansoni DNA ligase IV 0.0029 0.0056 0.0145
Schistosoma mansoni hypothetical protein 0.0082 0.0205 0.053
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0004 0.0005
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0026 0.0148
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0026 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0009 0.0048
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0004 0.0009
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.0076 0.1067
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0305 0.1769
Onchocerca volvulus 0.0014 0.0013 0.0177
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0163 0.0314
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0017 0.0043
Plasmodium falciparum casein kinase II beta chain 0.0036 0.0076 0.0073
Toxoplasma gondii thioredoxin reductase 0.0037 0.0078 0.0078
Echinococcus granulosus histone deacetylase 0.0616 0.172 0.4444
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0012 0.0007 0.0046
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0017 0.0083
Plasmodium vivax histone deacetylase 1, putative 0.0525 0.1463 0.1463
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0051
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0031 0.0044
Brugia malayi hypothetical protein 0.0011 0.0003 0.0019
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0031 0.0044
Brugia malayi ImpB/MucB/SamB family protein 0.0116 0.0302 0.1755
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0127 0.0727
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0169 0.0969
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0052 0.0043
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0052 0.0043
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0004 0.0009
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0525 0.1463 0.9468
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0051
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.0036 0.0054
Onchocerca volvulus 0.0058 0.0139 0.1957
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0178 0.0478 0.2769
Schistosoma mansoni ap endonuclease 0.0019 0.0026 0.0066
Entamoeba histolytica exonuclease, putative 0.001 0.0003 0.0017
Mycobacterium ulcerans hypothetical protein 0.0028 0.0053 0.0043
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0031 0.008
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0095 0.0243 0.0392
Entamoeba histolytica protein kinase, putative 0.0178 0.0478 0.3269
Entamoeba histolytica acyl-CoA synthetase, putative 0.0095 0.0243 0.1658
Brugia malayi histone deacetylase 1 (HD1) 0.0525 0.1463 0.8504
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.006 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0127 0.0727
Toxoplasma gondii patched family protein 0.0018 0.0024 0.0024
Trypanosoma cruzi FHA domain containing protein, putative 0.0029 0.0056 0.0321
Onchocerca volvulus 0.0099 0.0255 0.3593
Schistosoma mansoni topbp1 0.0029 0.0056 0.0145
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0732 0.4733
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0031 0.0179
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.023 0.0594
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0028 0.0052 0.0087
Echinococcus multilocularis acetylcholinesterase 0.0132 0.0347 0.05
Loa Loa (eye worm) hypothetical protein 0.0051 0.0118 0.0688
Echinococcus multilocularis histone deacetylase 8 0.0259 0.0708 0.1021
Loa Loa (eye worm) histone deacetylase 1 0.0525 0.1463 0.8504
Trypanosoma cruzi DNA polymerase eta, putative 0.0053 0.0124 0.0717
Echinococcus multilocularis dnaJ subfamily B 0.0833 0.2337 0.3368
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0062 0.0148 0.0148
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0009 0.0048
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0308 0.179
Brugia malayi hypothetical protein 0.0022 0.0036 0.0209
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0732 0.4733
Brugia malayi Niemann-Pick C1 protein precursor 0.0298 0.0818 0.4758
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0169 0.0969
Loa Loa (eye worm) hypothetical protein 0.0298 0.0818 0.4758
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0015 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Brugia malayi N-terminal motif family protein 0.0178 0.0477 0.277
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0209
Brugia malayi Ets-domain containing protein 0.0011 0.0004 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.023 0.0594
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0092 0.0092
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0062 0.0148 0.0861
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0052 0.0301
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0031 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0471 0.3039
Entamoeba histolytica DNA-repair protein, putative 0.001 0.0003 0.0017
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0052 0.0301
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Echinococcus granulosus cyclin dependent kinase 0.0043 0.0095 0.0244
Loa Loa (eye worm) glutathione reductase 0.0037 0.0078 0.0454
Trypanosoma brucei chrX additional, unordered contigs 0.0028 0.0053 0.0292
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0011 0.0003 0.0002
Schistosoma mansoni gabp alpha 0.0075 0.0186 0.048
Onchocerca volvulus 0.0095 0.0243 0.3422
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0033 0.0033
Brugia malayi Patched family protein 0.0018 0.0024 0.0139
Trypanosoma brucei trypanothione reductase 0.0037 0.0078 0.0441
Toxoplasma gondii zinc finger cdgsh type protein 0.0014 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0099 0.0255 0.148
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.024 0.0387
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0026 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0056 0.0348
Brugia malayi Patched family protein 0.0018 0.0024 0.0139
Brugia malayi Carboxylesterase family protein 0.0022 0.0036 0.0209
Echinococcus multilocularis histone deacetylase 6 0.0628 0.1754 0.2528
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0078 0.0438
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0015 0.0015 0.0104
Onchocerca volvulus 0.015 0.0397 0.5605
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0041 0.0064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.023 0.0594
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0031 0.0179
Echinococcus multilocularis replication factor c subunit 1 0.0029 0.0056 0.0081
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0011 0.0003 0.0019
Mycobacterium ulcerans DNA polymerase IV 0.0117 0.0305 0.0296
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0209
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0004 0.0005
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0031 0.0079
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0043 0.0095 0.0244
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0055 0.0046
Loa Loa (eye worm) apoptosis regulator protein 0.0082 0.0205 0.1193
Toxoplasma gondii chorismate synthase, putative 0.3533 1 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0015 0.0015 0.0087
Brugia malayi histone deacetylase 3 (HD3) 0.0525 0.1463 0.8504
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0118 0.0116
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0278 0.0718
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Echinococcus multilocularis histone deacetylase 1 0.0525 0.1463 0.2108
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0071 0.0174 0.0336
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0012 0.0007 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0031 0.0179
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0345 0.0891
Schistosoma mansoni cpg binding protein 0.0058 0.0139 0.0358
Leishmania major 4-coumarate:coa ligase-like protein 0.0095 0.0243 0.1398
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0011 0.0003 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0031 0.0179
Plasmodium vivax histone deacetylase 2, putative 0.0616 0.172 0.172
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0031 0.0179
Loa Loa (eye worm) glutaminase 2 0.0554 0.1545 0.8981
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0017 0.0043
Loa Loa (eye worm) hypothetical protein 0.0132 0.0347 0.2019
Entamoeba histolytica exonuclease, putative 0.001 0.0003 0.0017
Echinococcus granulosus GA binding protein alpha chain 0.0075 0.0186 0.048
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0015 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0157 0.0417 0.2426
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.038 0.0547
Echinococcus multilocularis tar DNA binding protein 0.0131 0.0345 0.0497
Echinococcus granulosus conserved hypothetical protein 0.0014 0.0013 0.0032
Brugia malayi hypothetical protein 0.0011 0.0003 0.0019
Toxoplasma gondii patched family protein 0.0018 0.0024 0.0024
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0325 0.0895 0.5204
Brugia malayi Carboxylesterase family protein 0.0132 0.0347 0.2019
Loa Loa (eye worm) hypothetical protein 0.0177 0.0474 0.2756
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0305 0.1762
Onchocerca volvulus 0.0018 0.0024 0.0337
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0091 0.023 0.0595
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0015 0.0088
Brugia malayi nuclear receptor NHR-88 0.002 0.0031 0.0179
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0031 0.0179
Loa Loa (eye worm) hypothetical protein 0.0071 0.0174 0.1013
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0017 0.0097
Onchocerca volvulus 0.0018 0.0024 0.0337
Schistosoma mansoni chromosome transmission fidelity factor 0.0029 0.0056 0.0145
Toxoplasma gondii hypothetical protein 0.0033 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0179
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0055 0.0342
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0076 0.0474
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0163 0.0314
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0033 0.0047
Loa Loa (eye worm) histone deacetylase 11 0.0259 0.0708 0.4119
Loa Loa (eye worm) hypothetical protein 0.0132 0.0347 0.2019
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0026 0.0175
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0031 0.008
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0017 0.0024
Onchocerca volvulus Protein patched homolog 0.0018 0.0024 0.0337
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0033 0.003
Leishmania major histone deacetylase, putative 0.0525 0.1463 0.8501
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0278 0.1616
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.0052 0.0087
Echinococcus granulosus bloom syndrome protein 0.002 0.0028 0.0073
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0026 0.0142
Schistosoma mansoni histone deacetylase 0.0525 0.1463 0.3779
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.0012 0.0007 0.0094
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0009 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0056 0.0348
Echinococcus granulosus expressed conserved protein 0.028 0.0767 0.1982
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0082 0.0205 0.053
Trypanosoma brucei unspecified product 0.0063 0.015 0.0861
Trypanosoma brucei histone deacetylase 3 0.0616 0.172 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0009 0.0048
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0076 0.0517
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0148 0.0198
Echinococcus granulosus geminin 0.0169 0.0453 0.117
Brugia malayi histone deacetylase 11 0.0259 0.0708 0.4119
Onchocerca volvulus 0.0018 0.0024 0.0337
Echinococcus granulosus cyclin dependent kinase 5 0.0043 0.0095 0.0244
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.0052 0.0052
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0027 0.0039
Echinococcus granulosus nibrin 0.0029 0.0056 0.0145
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Onchocerca volvulus 0.0018 0.0024 0.0337
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0305 0.1762
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0028 0.0052 0.0043
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0078 0.0202
Toxoplasma gondii XPG N-terminal domain-containing protein 0.001 0.0003 0.0003
Loa Loa (eye worm) glutaminase 0.0554 0.1545 0.8981
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0241 0.0241
Brugia malayi RE40412p 0.0014 0.0013 0.0073
Mycobacterium ulcerans hypothetical protein 0.0156 0.0417 0.0408
Leishmania major DNA polymerase kappa, putative 0.0097 0.0249 0.1435
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0017 0.0097
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0003 0.0002
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0029 0.0056 0.0047
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0031 0.0044
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0004 0.002
Echinococcus granulosus dual specificity 0.0178 0.0478 0.1235
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.0076 0.1067
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0278 0.0548
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0198 0.0536 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0009 0.004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0209
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0004 0.0005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0017 0.0024
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0015 0.0015 0.0015
Toxoplasma gondii XPG N-terminal domain-containing protein 0.001 0.0003 0.0003
Entamoeba histolytica protein kinase domain containing protein 0.0178 0.0478 0.3269
Brugia malayi RNA binding protein 0.0131 0.0345 0.2003
Plasmodium falciparum protein kinase 5 0.0043 0.0095 0.0092
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0471 0.3039
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0052 0.0301
Entamoeba histolytica hypothetical protein 0.0037 0.0078 0.0534
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0028 0.0164
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0091 0.0524
Loa Loa (eye worm) acetyltransferase 0.0143 0.038 0.2208
Loa Loa (eye worm) hypothetical protein 0.0177 0.0474 0.2756
Echinococcus multilocularis cyclin dependent kinase 0.0043 0.0095 0.0136
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0241 0.0622
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0015 0.0015 0.0015
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0055 0.0046
Schistosoma mansoni hypothetical protein 0.0248 0.0676 0.1746
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0003 0.0002
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0076 0.0474
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.001 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0031 0.0179
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0004 0.002
Echinococcus multilocularis GA binding protein alpha chain 0.0075 0.0186 0.0268
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0009 0.0024
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0092 0.0239
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0017 0.0017
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0001 0.0001
Loa Loa (eye worm) carboxylesterase 0.0132 0.0347 0.2019
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0561 0.3261
Trichomonas vaginalis histone deacetylase, putative 0.0525 0.1463 0.9468
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0026 0.0134
Loa Loa (eye worm) hypothetical protein 0.0599 0.1673 0.9725
Brugia malayi Pre-SET motif family protein 0.0031 0.006 0.0349
Loa Loa (eye worm) hypothetical protein 0.0071 0.0174 0.1013
Schistosoma mansoni alkaline phosphatase 0.0161 0.0429 0.111
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0039 0.0221
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0471 0.3039
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0073
Trypanosoma cruzi DNA damage repair protein, putative 0.0028 0.0053 0.03
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0055 0.0377
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0076 0.0474
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0278 0.1611
Loa Loa (eye worm) RNA binding protein 0.0131 0.0345 0.2003
Loa Loa (eye worm) histone deacetylase 7A 0.0616 0.172 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0525 0.1463 0.9468
Schistosoma mansoni glutaminase 0.0554 0.1545 0.3991
Toxoplasma gondii zinc finger CDGSH-type domain-containing protein 0.0014 0.0013 0.0013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.023 0.0594
Toxoplasma gondii XPG N-terminal domain-containing protein 0.001 0.0003 0.0003
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0055 0.0055
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0148 0.0214
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0148 0.0148
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.001 0.0051
Schistosoma mansoni hypothetical protein 0.0037 0.0078 0.0202
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0031 0.0079
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0015 0.0083
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0026 0.0158
Brugia malayi hypothetical protein 0.0018 0.0024 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0051
Schistosoma mansoni hypothetical protein 0.0308 0.0847 0.2188
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0028 0.0052 0.0355
Entamoeba histolytica hypothetical protein 0.0037 0.0078 0.0534
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0078 0.0201
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0055 0.0055
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0028 0.0041
Loa Loa (eye worm) hypothetical protein 0.0029 0.0055 0.0317
Loa Loa (eye worm) hypothetical protein 0.0095 0.0243 0.1409
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0011 0.0003 0.0019
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0092 0.0092
Leishmania major hypothetical protein, unknown function 0.0014 0.0013 0.0059
Toxoplasma gondii histone deacetylase HDAC2 0.0525 0.1463 0.1463
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0052 0.0119 0.0119
Schistosoma mansoni hypothetical protein 0.0082 0.0205 0.053
Echinococcus granulosus histone deacetylase 6 0.0616 0.172 0.4444
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0055 0.0055
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0009 0.0009
Echinococcus granulosus lysine specific histone demethylase 1A 0.0062 0.0148 0.0382
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.006 0.0087
Brugia malayi jmjC domain containing protein 0.0016 0.0017 0.0097
Toxoplasma gondii histone lysine-specific demethylase 0.0062 0.0148 0.0148
Leishmania major hypothetical protein, conserved 0.0012 0.0007 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0097 0.0249 0.1435
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0055 0.0078
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0015 0.0015 0.0088
Toxoplasma gondii hypothetical protein 0.0018 0.0024 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0056 0.0321
Loa Loa (eye worm) hypothetical protein 0.0095 0.0243 0.1409
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0078 0.0112
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0015 0.0015 0.0104
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0209
Echinococcus granulosus flap endonuclease 1 0.0052 0.0119 0.0308
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0031 0.0179
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0052 0.0043
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0065 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0305 0.1762
Loa Loa (eye worm) hypothetical protein 0.0028 0.0052 0.0301
Loa Loa (eye worm) hypothetical protein 0.0062 0.0148 0.0861
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0078 0.0141
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0026 0.0033
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.03 0.03
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0028 0.0168
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0065 0.1196
Brugia malayi Protein kinase domain containing protein 0.0043 0.0095 0.055
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.0816 0.4734
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0009 0.004
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.001 0.0003 0.0006
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0009 0.0007
Toxoplasma gondii PfMNL-2 CISD1 family iron-sulfur protein, putative 0.0014 0.0013 0.0013
Schistosoma mansoni ap endonuclease 0.0019 0.0026 0.0066
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0091 0.0517
Plasmodium vivax SET domain protein, putative 0.0031 0.006 0.006
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0028 0.0151
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0052 0.0301
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0095 0.0245
Brugia malayi amine oxidase, flavin-containing family protein 0.0062 0.0148 0.0861
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0179
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0052 0.0296
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0345 0.0891
Plasmodium falciparum DNA repair protein REV1, putative 0.0028 0.0053 0.005
Brugia malayi Pre-SET motif family protein 0.0207 0.0561 0.3261
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0278 0.1787
Brugia malayi Patched family protein 0.0018 0.0024 0.0139
Trichomonas vaginalis flap endonuclease-1, putative 0.0052 0.0119 0.0758
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0017 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0305 0.1762
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0169 0.0969
Loa Loa (eye worm) hypothetical protein 0.0082 0.0205 0.1193
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0029 0.0056 0.0348
Echinococcus granulosus protein C ets 2 0.0011 0.0004 0.0009
Schistosoma mansoni hypothetical protein 0.0123 0.0323 0.0833
Onchocerca volvulus 0.0018 0.0024 0.0337
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0214 0.0332
Entamoeba histolytica Flap nuclease, putative 0.0052 0.0119 0.0816
Plasmodium falciparum replication factor C subunit 1, putative 0.0029 0.0056 0.0054
Leishmania major DNA damage repair protein, putative 0.0028 0.0053 0.0292
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0026 0.0026
Chlamydia trachomatis dehyroquinate synthase 0.0126 0.0332 0.0323
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0026 0.0308
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0026 0.0457
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.001 0.0051
Onchocerca volvulus 0.0022 0.0036 0.0507
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0138 0.0356
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0151 0.0389
Loa Loa (eye worm) patched family protein 0.0018 0.0024 0.0139
Plasmodium falciparum histone deacetylase 1 0.0525 0.1463 0.146
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0091 0.0524
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0031 0.0179
Brugia malayi 6-phosphofructokinase 0.0108 0.0278 0.1617
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0031 0.008
Onchocerca volvulus 0.0022 0.0036 0.0507
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0078 0.0112
Brugia malayi casein kinase II, putaitve 0.0011 0.0003 0.0015
Trypanosoma cruzi UDP-galactopyranose mutase 0.0062 0.0148 0.0856
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0009 0.0009
Echinococcus multilocularis alkaline phosphatase 0.0161 0.0429 0.0619
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0241 0.0622
Echinococcus multilocularis carboxylesterase 5A 0.0132 0.0347 0.05
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0278 0.0718
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0031 0.0433
Treponema pallidum NADH oxidase 0.0013 0.0009 0.0154
Loa Loa (eye worm) flap endonuclease-1 0.0052 0.0119 0.0693
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0004 0.0009
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.001 0.0051
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.008 0.0206
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0033 0.0065 0.0027
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0031 0.0179
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0009 0.0048
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0082 0.008
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0095 0.0598
Brugia malayi Histone deacetylase 1 0.0525 0.1463 0.8504
Trypanosoma brucei histone deacetylase, putative 0.0616 0.172 1
Plasmodium falciparum thioredoxin reductase 0.0037 0.0078 0.0076
Brugia malayi Csnk2b protein 0.0036 0.0076 0.0439
Echinococcus granulosus histone deacetylase 3 0.0525 0.1463 0.3779
Echinococcus multilocularis microtubule associated protein 2 0.1373 0.387 0.5578
Trichomonas vaginalis glutaminase, putative 0.0554 0.1545 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0076 0.0474
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0004 0.0009
Brugia malayi Patched related family protein 10 0.0018 0.0024 0.0139
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0029 0.0056 0.0891
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0305 0.1769
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0028 0.0164
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0095 0.0243 0.0233
Echinococcus granulosus para nitrobenzyl esterase 0.0022 0.0036 0.0093
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0055 0.0303
Echinococcus multilocularis protein dispatched 1 0.0146 0.0387 0.0557
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0031 0.0079
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0878 0.2464 0.2457
Schistosoma mansoni flap endonuclease-1 0.0047 0.0105 0.0272
Trypanosoma brucei unspecified product 0.0111 0.0287 0.1654
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0026 0.0023
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0095 0.0598
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0082 0.0205 0.053
Entamoeba histolytica acyl-coA synthetase, putative 0.0095 0.0243 0.1658
Echinococcus multilocularis Niemann Pick C1 protein 0.0298 0.0818 0.1179
Echinococcus granulosus FTZ F1 alpha 0.002 0.0031 0.0079
Plasmodium falciparum lipid/sterol:H+ symporter 0.0018 0.0024 0.0021
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0151 0.0875
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0001 0.0001
Schistosoma mansoni coup transcription factor 0.002 0.0031 0.008
Trypanosoma cruzi histone deacetylase 1, putative 0.0525 0.1463 0.8503
Brugia malayi hypothetical protein 0.015 0.0397 0.2309
Plasmodium falciparum protoporphyrinogen oxidase 0.0062 0.0148 0.0146
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0128 0.0336 0.1951
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0031 0.0179
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0078 0.02
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.0345 0.2003
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0055 0.0342
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0014 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.0451
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0004 0.0005
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0003 0.0002
Brugia malayi Histone deacetylase family protein 0.0616 0.172 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.0417 0.083
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0055 0.0053
Schistosoma mansoni histone deacetylase hda2 0.0628 0.1754 0.4532
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.0076 0.0434
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.0052 0.0087
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0015 0.0015 0.0088
Schistosoma mansoni hypothetical protein 0.0082 0.0205 0.053
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0161 0.0429 0.0619
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0052 0.032
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0055 0.0053
Mycobacterium tuberculosis Possible oxidoreductase 0.0062 0.0148 0.0283
Schistosoma mansoni hypothetical protein 0.0063 0.0151 0.0389
Brugia malayi Patched related family protein 12 0.0018 0.0024 0.0139
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0278 0.1604
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0076 0.0474
Echinococcus multilocularis 0.0062 0.0148 0.0213
Loa Loa (eye worm) hypothetical protein 0.0049 0.0113 0.0657
Brugia malayi cell division control protein 2 homolog 0.0043 0.0095 0.055
Echinococcus granulosus histone deacetylase 1 0.0525 0.1463 0.3779
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0009 0.0044
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0015 0.0015 0.0083
Brugia malayi AMP-binding enzyme family protein 0.0095 0.0243 0.1409
Schistosoma mansoni hypothetical protein 0.0023 0.0038 0.0098
Brugia malayi 6-phosphofructokinase 0.0108 0.0278 0.1616
Loa Loa (eye worm) hypothetical protein 0.0028 0.0052 0.0301
Brugia malayi CXXC zinc finger family protein 0.0058 0.0139 0.0806
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.006 0.0155
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0076 0.0474
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0015 0.0015 0.0074
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0063 0.0151 0.0875
Schistosoma mansoni microtubule-associated protein tau 0.1373 0.387 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0028 0.0053 0.03
Echinococcus granulosus sterol regulatory element binding protein 0.0128 0.0336 0.0867
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0055 0.0055
Trypanosoma cruzi histone deacetylase, putative 0.0259 0.0708 0.4115
Echinococcus granulosus dnaJ subfamily B 0.0833 0.2337 0.6038
Echinococcus granulosus cyclin dependent kinase 1 0.0043 0.0095 0.0244
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.023 0.0331
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0003 0.0002
Plasmodium falciparum histone deacetylase, putative 0.0616 0.172 0.1718
Schistosoma mansoni topbp1 0.0029 0.0056 0.0145
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0278 0.1616
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0062 0.0148 0.0861
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0038 0.0098
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0278 0.1901
Schistosoma mansoni gliotactin 0.0022 0.0036 0.0093
Trichomonas vaginalis casein kinase II beta chain, putative 0.0011 0.0003 0.0002
Brugia malayi hypothetical protein 0.0051 0.0118 0.0688
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0017 0.0044
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0525 0.1463 0.9468
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0017 0.0043
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0028 0.0052 0.0087
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0097 0.0249 0.1435
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0036 0.0093
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.001 0.0051
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2454 0.6938 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0097
Echinococcus granulosus GPCR family 2 0.0063 0.0151 0.0389
Plasmodium vivax exonuclease I, putative 0.001 0.0003 0.0003
Trypanosoma brucei DNA polymerase IV, putative 0.0117 0.0305 0.1762
Echinococcus granulosus cpg binding protein 0.0062 0.0148 0.0383
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0035 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0031 0.006 0.0349
Schistosoma mansoni hypothetical protein 0.0123 0.0323 0.0833
Trypanosoma cruzi histone deacetylase, putative 0.0616 0.172 1
Trichomonas vaginalis histone deacetylase, putative 0.0525 0.1463 0.9468
Plasmodium vivax glutathione reductase, putative 0.0037 0.0078 0.0078
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0095 0.0243 0.0475
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0029 0.0056 0.0348
Echinococcus multilocularis muscleblind protein 1 0.0599 0.1673 0.2411
Trypanosoma brucei histone deacetylase 1 0.0525 0.1463 0.8501
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0009 0.004
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0076 0.0474
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0139
Trypanosoma cruzi UDP-galactopyranose mutase 0.0062 0.0148 0.0856
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.0847 0.4922
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0031 0.0179
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0095 0.0245
Plasmodium falciparum histone deacetylase 2 0.0616 0.172 0.1718
Entamoeba histolytica cell division protein kinase 2, putative 0.0043 0.0095 0.0648
Echinococcus multilocularis cpg binding protein 0.0062 0.0148 0.0213
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0052 0.0087
Trypanosoma brucei cdc2-related kinase 3 0.0043 0.0095 0.0537
Echinococcus granulosus microtubule associated protein 2 0.1373 0.387 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0033 0.0185
Leishmania major UDP-galactopyranose mutase 0.0062 0.0148 0.0848
Echinococcus multilocularis geminin 0.0169 0.0453 0.0653
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0126 0.0332 0.0575
Brugia malayi nuclear hormone receptor 0.002 0.0031 0.0179
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0161 0.0429 0.1109
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0043 0.0095 0.0095
Plasmodium falciparum acyl-CoA synthetase 0.0071 0.0174 0.0172
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0161 0.0429 0.0619
Echinococcus granulosus neuroligin 0.0022 0.0036 0.0093
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0028 0.0151
Schistosoma mansoni alkaline phosphatase 0.0161 0.0429 0.111
Loa Loa (eye worm) patched family protein 0.0018 0.0024 0.0139
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0017 0.0044
Giardia lamblia DNA damage repair protein 0.0028 0.0053 0.0344
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0097 0.0249 0.0488
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0004 0.0005
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0009 0.004
Echinococcus multilocularis GPCR, family 2 0.0063 0.0151 0.0217
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.006 0.0155
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0004 0.002
Loa Loa (eye worm) histone deacetylase 3 0.0525 0.1463 0.8504
Schistosoma mansoni amine oxidase 0.0062 0.0148 0.0383
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0009 0.0053
Echinococcus multilocularis histone deacetylase 0.0616 0.172 0.2479

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0828 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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