Detailed information for compound 134766

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 239.231 | Formula: C9H13N5O3
  • H donors: 4 H acceptors: 6 LogP: -2.21 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC(C(Cn1cnc2c1ncnc2O)N)O
  • InChi: 1S/C9H13N5O3/c10-5(6(16)2-15)1-14-4-13-7-8(14)11-3-12-9(7)17/h3-6,15-16H,1-2,10H2,(H,11,12,17)
  • InChiKey: YMQWBLRLMCNGGN-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major sterol 24-c-methyltransferase, putative 0.0191 0.1306 0.551
Plasmodium falciparum transporter, putative 0.0034 0.0174 0.1487
Leishmania major cytochrome p450-like protein 0.0015 0.004 0.0078
Leishmania major heat shock protein 83-1 0.0045 0.0256 0.1006
Leishmania major heat shock protein 83-1 0.0045 0.0256 0.1006
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0159 0.0427
Trypanosoma brucei phospholipase A1, putative 0.0337 0.2353 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0034 0.0174 0.0555
Echinococcus granulosus Peptidase C54 0.0117 0.0769 0.207
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0078 0.0407
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0045 0.0257 0.1011
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0398 0.1072
Loa Loa (eye worm) hypothetical protein 0.0368 0.2579 0.2579
Entamoeba histolytica peptidase, C54 family 0.0045 0.0257 0.1044
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0256 0.1006
Schistosoma mansoni sodium-dependent amino acid transporter 0.0034 0.0174 0.0468
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0078 0.0407
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.0256 0.1087
Plasmodium falciparum importin beta, putative 0.0034 0.0172 0.1473
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0147 0.0003
Brugia malayi PHD-finger family protein 0.0015 0.0037 0.0119
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0144 0.1199
Brugia malayi RNA binding protein 0.0125 0.0831 0.2653
Loa Loa (eye worm) hypothetical protein 0.0235 0.1622 0.1622
Brugia malayi hypothetical protein 0.017 0.1153 0.368
Echinococcus granulosus dynamin 0.0023 0.0096 0.0258
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0034 0.0174 0.0555
Plasmodium falciparum endoplasmin, putative 0.0033 0.0167 0.1426
Entamoeba histolytica hypothetical protein 0.0098 0.0633 0.2615
Plasmodium vivax importin-beta 2, putative 0.0034 0.0172 0.1176
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0144 0.0388
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.002 0.0073 0.038
Loa Loa (eye worm) hypothetical protein 0.0033 0.0164 0.0164
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0015 0.004 0.0078
Schistosoma mansoni hypothetical protein 0.0525 0.371 1
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0021 0.0059
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0034 0.0174 0.0468
Trypanosoma brucei heat shock protein, putative 0.0045 0.0256 0.1087
Leishmania major heat shock protein 83-1 0.0045 0.0256 0.1006
Schistosoma mansoni ran 0.0025 0.0108 0.0292
Trichomonas vaginalis dynamin, putative 0.0023 0.0096 0.0516
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0073 0.0223
Entamoeba histolytica peptidase, C54 family 0.0045 0.0257 0.1044
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0191 0.1306 0.551
Brugia malayi S-adenosyl-methionine cycloartenol-C24-methyltransferase 0.0093 0.0601 0.1918
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0009 0.00000000017277
Leishmania major heat shock protein 83-1 0.0045 0.0256 0.1006
Onchocerca volvulus 0.0034 0.0174 0.003
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.032 0.2743
Loa Loa (eye worm) hypothetical protein 0.0051 0.0297 0.0296
Leishmania major heat shock protein, putative 0.003 0.0147 0.0537
Loa Loa (eye worm) CXXC zinc finger family protein 0.0091 0.0582 0.0582
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0101 0.0543
Plasmodium vivax heat shock protein 90, putative 0.003 0.0147 0.0949
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0398 0.1072
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.002 0.0073 0.0611
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.032 0.2665
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.002 0.0073 0.0223
Schistosoma mansoni hypothetical protein 0.0037 0.0195 0.0527
Schistosoma mansoni hypothetical protein 0.0141 0.0942 0.2538
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.002 0.0073 0.038
Loa Loa (eye worm) norepinephrine transporter 0.0034 0.0174 0.0173
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0108 0.0608
Leishmania major GTP-binding protein, putative 0.0023 0.0096 0.0321
Leishmania major GTP-binding protein, putative 0.0025 0.0108 0.0373
Echinococcus multilocularis sodium and chloride dependent glycine 0.0034 0.0174 0.0467
Schistosoma mansoni endoplasmin 0.0045 0.0256 0.069
Echinococcus granulosus heat shock protein 0.0045 0.0256 0.0688
Brugia malayi hypothetical protein 0.0034 0.0174 0.0555
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0144 0.1199
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0159 0.1324
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0159 0.136
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.002 0.0073 0.038
Trichomonas vaginalis heat shock protein, putative 0.0026 0.012 0.0655
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0159 0.0158
Schistosoma mansoni hypothetical protein 0.0065 0.0398 0.1074
Loa Loa (eye worm) hypothetical protein 0.0224 0.1539 0.1538
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.004 0.0168
Loa Loa (eye worm) hypothetical protein 0.0224 0.1539 0.1538
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.0256 0.1006
Leishmania major phospholipase A1, putative 0.0337 0.2353 1
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.012 0.1021
Toxoplasma gondii exonuclease III APE 0.0019 0.0069 0.0573
Schistosoma mansoni DNA helicase recq1 0.001 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0037
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0224 0.1539 0.4148
Giardia lamblia DNA repair protein RAD52 0.0343 0.2402 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0034 0.0174 0.0467
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0034 0.0174 0.0555
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.1479 0.1478
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0244 0.1819
Schistosoma mansoni hypothetical protein 0.0525 0.371 1
Brugia malayi Hsp90 protein 0.003 0.0147 0.0468
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0218 0.1869
Brugia malayi Inositol-1 0.0042 0.0229 0.0731
Loa Loa (eye worm) hypothetical protein 0.017 0.1153 0.1152
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0045 0.0257 0.1011
Plasmodium falciparum phd finger protein, putative 0.003 0.0144 0.1231
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.002 0.0073 0.0277
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0831 0.2239
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0034 0.0174 0.0467
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0034 0.0174 0.0467
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0229 0.0926
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0174 0.1191
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0164 0.0443
Echinococcus granulosus endoplasmin 0.0042 0.0236 0.0634
Trypanosoma brucei dynamin-1-like protein 0.0023 0.0096 0.0409
Loa Loa (eye worm) solute carrier family 6 member 4 0.0034 0.0174 0.0173
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0173
Brugia malayi hypothetical protein 0.0054 0.032 0.1021
Leishmania major lanosterol synthase, putative 0.0126 0.0833 0.3483
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0078 0.0407
Toxoplasma gondii hypothetical protein 0.0034 0.0174 0.1448
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0244 0.1397
Echinococcus granulosus heat shock protein 90 0.0039 0.0209 0.0561
Brugia malayi hypothetical protein 0.0037 0.0195 0.0624
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0117 0.0769 0.4516
Toxoplasma gondii heat shock protein HSP90 0.0045 0.0256 0.2132
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0108 0.0924
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0108 0.046
Loa Loa (eye worm) hypothetical protein 0.0119 0.0789 0.0789
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0154 0.1041 0.4374
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0398 0.1272
Brugia malayi Cytochrome P450 family protein 0.0015 0.004 0.0126
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0172 0.1433
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0069 0.0258
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0159 0.0427
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0275 0.0879
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0069 0.0184
Trichomonas vaginalis helicase, putative 0.0021 0.0078 0.0407
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0069 0.0204
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0209 0.0804
Brugia malayi cytochrome P450 0.0015 0.004 0.0126
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0001 0.0002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0206 0.141 0.4501
Trypanosoma cruzi protein farnesyltransferase, putative 0.002 0.0073 0.0223
Leishmania major heat shock protein 83-1 0.0045 0.0256 0.1006
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0359 0.2513 0.2512
Entamoeba histolytica dynamin-1-like protein, putative 0.0023 0.0096 0.0372
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0081 0.0509 1
Brugia malayi Importin beta-1 subunit 0.0034 0.0172 0.0549
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0108 0.029
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0244 0.1397
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0045 0.0257 0.2142
Trypanosoma cruzi lanosterol synthase, putative 0.0145 0.0977 0.4097
Echinococcus multilocularis serotonin transporter 0.0034 0.0174 0.0467
Plasmodium falciparum zinc finger protein, putative 0.0011 0.0007 0.0056
Brugia malayi latrophilin 2 splice variant baaae 0.0141 0.0942 0.3007
Plasmodium vivax farnesyltransferase beta subunit, putative 0.002 0.0073 0.0299
Loa Loa (eye worm) serotonin transporter b 0.0034 0.0174 0.0173
Brugia malayi jmjC domain containing protein 0.0097 0.063 0.2012
Echinococcus granulosus importin subunit beta 1 0.0034 0.0172 0.0462
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0371 0.0371
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.002 0.0073 0.0196
Onchocerca volvulus Phospholipase A2 homolog 0.0368 0.2579 0.2471
Loa Loa (eye worm) histone methyltransferase 0.0029 0.014 0.0139
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.002 0.0073 0.0277
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0034 0.0174 0.0467
Trypanosoma cruzi phospholipase A1, putative 0.0337 0.2353 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0036 0.0096
Brugia malayi heat shock protein 90 0.0045 0.0256 0.0817
Echinococcus granulosus mixed lineage leukemia protein mll 0.0024 0.01 0.0269
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0256 0.1063
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0078 0.0407
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0244 0.2036
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.002 0.0073 0.038
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.004 0.0039
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0021 0.0071
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.0236 0.4178
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0164 0.0442
Trichomonas vaginalis ran, putative 0.0025 0.0108 0.0587
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0078 0.0407
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0001 0.0005
Trypanosoma brucei heat shock protein, putative 0.0045 0.0256 0.1087
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0147 0.0623
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0108 0.029
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0226 0.0609
Trypanosoma brucei heat shock protein, putative 0.0045 0.0256 0.1087
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0229 0.089
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0831 0.2239
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.004 0.0078
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0067 0.0194
Plasmodium falciparum cysteine protease ATG4, putative 0.0045 0.0257 0.2204
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.063 0.1697
Plasmodium falciparum geranylgeranyltransferase, putative 0.002 0.0073 0.0625
Plasmodium vivax geranylgeranyltransferase, putative 0.002 0.0073 0.0299
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0147 0.0582
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0173
Schistosoma mansoni ap endonuclease 0.0019 0.0069 0.0185
Entamoeba histolytica hypothetical protein 0.0037 0.0195 0.0786
Echinococcus multilocularis endoplasmin 0.0042 0.0236 0.0634
Leishmania major sterol 24-c-methyltransferase, putative 0.0191 0.1306 0.551
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0195 0.0527
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0198 0.8051
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.018 0.018
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0191 0.1306 0.555
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0034 0.0174 0.0555
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0069 0.0353
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0042 0.0236 1
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.002 0.0073 0.0234
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.002 0.0073 0.0611
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.002 0.0073 0.0234
Schistosoma mansoni myst-related protein 0.0011 0.0007 0.0019
Echinococcus multilocularis heat shock protein 90 0.0045 0.0256 0.0688
Plasmodium vivax heat shock protein, putative 0.0172 0.1165 1
Loa Loa (eye worm) platelet-activating factor acetylhydrolase 0.0337 0.2353 0.2353
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0398 0.1072
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0034 0.0174 0.1448
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.002 0.0073 0.0234
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0343 0.2402 1
Toxoplasma gondii hypothetical protein 0.0034 0.0174 0.1448
Brugia malayi Cytochrome P450 family protein 0.0015 0.004 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0078 0.0407
Giardia lamblia Grp94/Hsp90 0.0042 0.0236 0.098
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.002 0.0073 0.0196
Trypanosoma brucei dynamin-1-like protein 0.0023 0.0096 0.0409
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0167 0.0935
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0228 0.0612
Echinococcus granulosus cysteine protease atg4b 0.0117 0.0769 0.207
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.1622 0.4371
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0144 0.0386
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0034 0.0174 0.5
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0224 0.1539 0.4147
Giardia lamblia Dynamin 0.0023 0.0096 0.0399
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0034 0.0174 0.0468
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0069 0.0586
Schistosoma mansoni hypothetical protein 0.0015 0.004 0.0107
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0034 0.0174 0.1448
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0117 0.0769 0.4516
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0105 0.0281
Echinococcus granulosus vesicular acetylcholine transporter 0.0445 0.3132 0.8441
Echinococcus granulosus serotonin transporter 0.0034 0.0174 0.0467
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0147 0.1221
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0001 0.0005
Entamoeba histolytica hypothetical protein 0.0037 0.0195 0.0786
Echinococcus granulosus dynamin 1 0.0025 0.0109 0.0292
Brugia malayi Pre-SET motif family protein 0.0215 0.1479 0.4722
Schistosoma mansoni inositol monophosphatase 0.0042 0.0229 0.0617
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0073
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0039 0.0209 0.0561
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0065 0.0175
Giardia lamblia Rab geranylgeranyltransferase 0.002 0.0073 0.0303
Schistosoma mansoni cpg binding protein 0.0096 0.062 0.167
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0224 0.1539 0.4148
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0078 0.0407
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0228 0.0612
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0108 0.0373
Echinococcus granulosus geminin 0.0525 0.371 1
Entamoeba histolytica hypothetical protein 0.0027 0.0126 0.0498
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0831 0.2239
Echinococcus granulosus sodium and chloride dependent glycine 0.0034 0.0174 0.0467
Leishmania major heat shock protein 83-1 0.0045 0.0256 0.1006
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.004 0.0078
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0256 0.1087
Echinococcus granulosus dnaJ subfamily B 0.0419 0.2946 0.7939
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.032 0.2743
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.032 0.1359
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.002 0.0073 0.0625
Leishmania major heat shock protein 83-1 0.0045 0.0256 0.1006
Onchocerca volvulus 0.017 0.1153 0.1023
Trichomonas vaginalis dynamin, putative 0.0023 0.0096 0.0516
Echinococcus multilocularis cysteine protease atg4b 0.0117 0.0769 0.207
Onchocerca volvulus 0.0048 0.0275 0.0133
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0117 0.0769 0.4516
Schistosoma mansoni hypothetical protein 0.0359 0.2513 0.6772
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.002 0.0073 0.0611
Loa Loa (eye worm) hypothetical protein 0.0141 0.0942 0.0941
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.002 0.0073 0.038
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.01 0.0269
Plasmodium vivax dynamin protein, putative 0.0023 0.0096 0.0502
Onchocerca volvulus 0.0033 0.0164 0.0021
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0164 0.0442
Toxoplasma gondii dynamin gtpase 0.0015 0.004 0.033
Schistosoma mansoni protein farnesyltransferase subunit beta 0.002 0.0073 0.0198
Entamoeba histolytica dynamin-like protein 0.0023 0.0096 0.0372
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0117 0.0769 0.2072
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0172 0.0731
Echinococcus granulosus cpg binding protein 0.0096 0.062 0.1669
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0236 0.1347
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.0999 0.3189
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0229 0.1306
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.0108 0.0448
Trypanosoma brucei heat shock protein, putative 0.0045 0.0256 0.1087
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0159 0.0507
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0034 0.0174 0.0467
Plasmodium vivax dynamin-like protein, putative 0.0023 0.0096 0.0502
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.002 0.0073 0.0198
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0159 0.254
Loa Loa (eye worm) hypothetical protein 0.0054 0.032 0.0319
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0144 0.0386
Loa Loa (eye worm) heat shock protein 75 0.003 0.0147 0.0146
Schistosoma mansoni ap endonuclease 0.0019 0.0069 0.0185
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0209 0.0804
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0164 0.0443
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0034 0.0174 0.1448
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0069 0.0204
Schistosoma mansoni importin beta-1 0.0034 0.0172 0.0464
Echinococcus multilocularis peregrin 0.0033 0.017 0.0457
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0034 0.0174 0.0468
Leishmania major heat shock protein 83-1 0.0045 0.0256 0.1006
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.0236 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0206 0.141 0.1409
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.032 0.249
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.063 0.1697
Brugia malayi Cytochrome P450 family protein 0.0035 0.018 0.0576
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0159 0.1324
Giardia lamblia Prenyltransferase 0.002 0.0073 0.0303
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0244 0.2036
Plasmodium vivax endoplasmin, putative 0.0045 0.0256 0.1921
Schistosoma mansoni autophagin-1 (C54 family) 0.0117 0.0769 0.2072
Schistosoma mansoni dynamin 0.0023 0.0096 0.0259
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0098 0.0633 0.2615
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0159 0.0427
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0069 0.0292
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0159 0.059
Toxoplasma gondii dynamin-related protein DRPB 0.0023 0.0096 0.0802
Plasmodium vivax hypothetical protein, conserved 0.003 0.0144 0.0925
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.002 0.0073 0.0198
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0034 0.0174 0.0467
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0044 0.0368
Schistosoma mansoni hypothetical protein 0.0048 0.0275 0.0742
Loa Loa (eye worm) hypothetical protein 0.0065 0.0398 0.0398
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0078 0.0407
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0229 0.089
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0078 0.0407
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0105 0.0281
Mycobacterium ulcerans heat shock protein 90 0.0042 0.0236 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0101 0.0543
Trichomonas vaginalis mgm1, putative 0.0023 0.0096 0.0516
Brugia malayi TAR-binding protein 0.0125 0.0831 0.2653
Schistosoma mansoni hypothetical protein 0.0419 0.2946 0.7939
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0224 0.1539 0.4147
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0069 0.0622
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0159 0.059
Loa Loa (eye worm) hypothetical protein 0.0093 0.0601 0.06
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0256 0.1087
Trichomonas vaginalis dynamin, putative 0.0023 0.0096 0.0516
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.01 0.0269
Trypanosoma brucei lanosterol synthase 0.0145 0.0977 0.415
Plasmodium vivax SET domain protein, putative 0.0033 0.0164 0.1109
Brugia malayi Dynamin 0.0025 0.0109 0.0348
Leishmania major heat shock protein 83-1 0.0045 0.0256 0.1006
Leishmania major heat shock protein 83-1 0.0045 0.0256 0.1006
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0159 0.1059
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.002 0.0073 0.0073
Plasmodium vivax heat shock protein 86, putative 0.0045 0.0256 0.1921
Onchocerca volvulus 0.0091 0.0582 0.0445
Loa Loa (eye worm) hypothetical protein 0.0206 0.141 0.1409
Onchocerca volvulus 0.0337 0.2353 0.2242
Brugia malayi Dynamin central region family protein 0.0023 0.0096 0.0307
Brugia malayi isocitrate dehydrogenase 0.0032 0.0159 0.0507
Leishmania major hypothetical protein, conserved 0.0054 0.032 0.128
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0195 0.0525
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0034 0.0174 0.0468
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.002 0.0073 0.0299
Onchocerca volvulus 0.0337 0.2353 0.2242
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0229 0.9646
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.002 0.0073 0.0196
Echinococcus granulosus bloom syndrome protein 0.0024 0.0101 0.027
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0101 0.027
Loa Loa (eye worm) TAR-binding protein 0.0125 0.0831 0.083
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.004 0.0078
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0191 0.1306 0.551
Loa Loa (eye worm) heat shock protein 90 0.0045 0.0256 0.0255
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0108 0.0345
Plasmodium vivax amine transporter, putative 0.0034 0.0174 0.1191
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.002 0.0073 0.038
Entamoeba histolytica hypothetical protein 0.0037 0.0195 0.0786
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0189 0.0507
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0159 0.0675
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0172 0.0462
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0206 0.141 0.4501
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0226 0.0608
Echinococcus multilocularis Peptidase C54 0.0117 0.0769 0.207
Brugia malayi Phospholipase A2 family protein 0.0368 0.2579 0.8236
Echinococcus granulosus snurportin 1 0.0359 0.2513 0.6771
Toxoplasma gondii dynamin-related protein DRPA 0.0023 0.0096 0.0802
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0398 0.0398
Echinococcus granulosus tar DNA binding protein 0.0125 0.0831 0.2238
Leishmania major heat shock protein 83-1 0.0045 0.0256 0.1006
Brugia malayi Bromodomain containing protein 0.0033 0.017 0.0543
Loa Loa (eye worm) hypothetical protein 0.0034 0.0172 0.0171
Schistosoma mansoni cytochrome P450 0.0015 0.004 0.0107
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0078 0.0407
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0191 0.1306 0.555
Echinococcus multilocularis heat shock protein 90 0.0039 0.0209 0.0561
Trypanosoma brucei heat shock protein, putative 0.0045 0.0256 0.1087
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0229 0.0973
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0256 0.1006
Plasmodium falciparum dynamin-like protein 0.0023 0.0096 0.0822
Echinococcus granulosus GPCR family 2 0.0065 0.0398 0.1072
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0173
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0073 0.0223
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.014 0.0376
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0159 0.0428
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0117 0.0769 0.4516
Leishmania major importin beta-1 subunit, putative 0.0027 0.0126 0.045
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0173
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0256 0.1006
Trypanosoma brucei heat shock protein, putative 0.0045 0.0256 0.1087
Plasmodium falciparum dynamin-like protein 0.0023 0.0096 0.0822
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0021 0.0091
Brugia malayi PHD-finger family protein 0.003 0.0144 0.0459
Leishmania major heat shock protein 83-1 0.0045 0.0256 0.1006
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0244 0.0657
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.004 0.0105
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0173
Leishmania major heat shock protein 83-1 0.0045 0.0256 0.1006
Echinococcus multilocularis cpg binding protein 0.0096 0.062 0.1669
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0173
Trypanosoma cruzi protein farnesyltransferase, putative 0.002 0.0073 0.0223
Echinococcus granulosus peregrin 0.0033 0.017 0.0457
Echinococcus multilocularis dynamin 1 protein 0.0023 0.0096 0.0258
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0101 0.0322
Onchocerca volvulus 0.0034 0.0174 0.003
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0486 0.1311
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0229 0.1306
Treponema pallidum heat shock protein 90 0.0042 0.0236 1
Trypanosoma brucei heat shock protein, putative 0.0045 0.0256 0.1087
Echinococcus multilocularis geminin 0.0525 0.371 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0108 0.0373
Schistosoma mansoni dynamin 0.0025 0.0109 0.0294
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0159 0.0427
Trichomonas vaginalis dynamin, putative 0.0023 0.0096 0.0516
Schistosoma mansoni DNA helicase recq5 0.001 0.0001 0.0002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.014 0.0376
Brugia malayi hypothetical protein 0.0035 0.0182 0.058
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0069 0.1488
Loa Loa (eye worm) inositol-1 0.0042 0.0229 0.0228
Loa Loa (eye worm) RNA binding protein 0.0125 0.0831 0.083
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0078 0.0407
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.0999 0.2691
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0033 0.017 0.0459
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.004 0.0078
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.0831 0.083
Echinococcus granulosus sodium and chloride dependent glycine 0.0034 0.0174 0.0467
Brugia malayi Peptidase family C54 containing protein 0.0117 0.0769 0.2454
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.01 0.0648 0.2753
Schistosoma mansoni inositol monophosphatase 0.0042 0.0229 0.0617
Trichomonas vaginalis dynamin, putative 0.0023 0.0096 0.0516
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0069 0.0204
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0224 0.1539 0.4148
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0159 0.0675
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.032 0.128
Onchocerca volvulus 0.0337 0.2353 0.2242
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.0831 0.2653
Brugia malayi Dynamin 0.0025 0.0109 0.0348
Plasmodium falciparum heat shock protein 90, putative 0.0172 0.1165 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0032 0.0086
Entamoeba histolytica hypothetical protein 0.0037 0.0195 0.0786
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0117 0.0769 0.3205
Schistosoma mansoni dynamin 0.0025 0.0109 0.0294
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0229 0.1907
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0117 0.0769 0.3266
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0069 0.0353
Toxoplasma gondii histone lysine methyltransferase SET1 0.0177 0.12 1
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0236 0.1347
Plasmodium falciparum amino acid transporter, putative 0.0034 0.0174 0.1487
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0069 0.0068
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0831 0.2239
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.004 0.0039
Brugia malayi RNA, U transporter 1 0.0096 0.0618 0.1973
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0256 0.1006
Echinococcus multilocularis GPCR, family 2 0.0065 0.0398 0.1072
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0034 0.0174 0.0173
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0159 0.0427
Echinococcus multilocularis heat shock protein 0.0045 0.0256 0.0688
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0154 0.1041 0.4374
Schistosoma mansoni endoplasmin 0.0045 0.0256 0.069
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0117 0.0769 0.2072
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0015 0.004 0.0337
Plasmodium falciparum protein farnesyltransferase subunit beta 0.002 0.0073 0.0625
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.0999 0.2692
Leishmania major farnesyltransferase beta subunit 0.002 0.0073 0.0223
Onchocerca volvulus 0.0034 0.0174 0.003
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.002 0.0073 0.0198
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0142 0.0382
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0078 0.0407
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0045 0.0257 0.1011
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.002 0.0073 0.0277
Loa Loa (eye worm) endoplasmin 0.0045 0.0256 0.0255
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0226 0.0609
Entamoeba histolytica peptidase, C54 family 0.0045 0.0257 0.1044
Trypanosoma cruzi lanosterol synthase, putative 0.0145 0.0977 0.4097
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.002 0.0073 0.038
Schistosoma mansoni heat shock protein 0.0045 0.0256 0.069
Schistosoma mansoni hypothetical protein 0.0065 0.0398 0.1074
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0198 0.3364
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0229 0.1306
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0069 0.0258
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0126 0.0695
Leishmania major heat shock protein 83-1 0.0045 0.0256 0.1006
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0069 0.0284
Brugia malayi Pre-SET motif family protein 0.0033 0.0164 0.0525
Trichomonas vaginalis endoplasmin, putative 0.0033 0.0167 0.0935
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0034 0.0174 0.0468
Brugia malayi Cytochrome P450 family protein 0.0015 0.004 0.0126
Schistosoma mansoni heat shock protein 0.0045 0.0256 0.069
Leishmania major heat shock protein 83-1 0.0045 0.0256 0.1006
Schistosoma mansoni cpg binding protein 0.0091 0.0582 0.157
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.002 0.0073 0.0312
Brugia malayi F/Y-rich N-terminus family protein 0.0039 0.0207 0.0662
Brugia malayi jmjC domain containing protein 0.0041 0.0226 0.0722
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0164 0.0443
Plasmodium falciparum heat shock protein 90 0.0045 0.0256 0.2193
Trypanosoma brucei cytochrome P450, putative 0.0015 0.004 0.0168
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0229 0.0616
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0226 0.0225
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0108 0.0108
Onchocerca volvulus Phospholipase A2 homolog 0.1399 1 1
Trypanosoma brucei protein farnesyltransferase beta subunit 0.002 0.0073 0.0312
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.0969 0.261
Treponema pallidum sodium- and chloride- dependent transporter 0.0034 0.0174 0.6281
Schistosoma mansoni sodium/chloride dependent transporter 0.0034 0.0174 0.0468
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0144 0.0143
Echinococcus multilocularis 0.0015 0.004 0.0105
Schistosoma mansoni myst-related protein 0.0011 0.0007 0.0019
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0108
Echinococcus granulosus protein farnesyltransferase subunit beta 0.002 0.0073 0.0196
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0193 0.1322 0.3563
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.002 0.0073 0.038
Brugia malayi hypothetical protein 0.0235 0.1622 0.518
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0034 0.0174 0.0173
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0034 0.0174 0.0468
Echinococcus multilocularis vesicular acetylcholine transporter 0.0445 0.3132 0.8441
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0078 0.0407
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0078 0.0407
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0209 0.1186
Schistosoma mansoni survival motor neuron protein 0.0048 0.0275 0.0742
Schistosoma mansoni hypothetical protein 0.003 0.0144 0.0388
Loa Loa (eye worm) hypothetical protein 0.003 0.0144 0.0143
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0229 0.089
Schistosoma mansoni sodium/chloride dependent transporter 0.0034 0.0174 0.0468
Brugia malayi Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein 0.0337 0.2353 0.7514
Schistosoma mansoni sodium/chloride dependent transporter 0.0034 0.0174 0.0468
Loa Loa (eye worm) RecQ helicase 0.0024 0.0101 0.01
Schistosoma mansoni vesicular acetylcholine transporter 0.0445 0.3132 0.8441
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0256 0.1466
Schistosoma mansoni heat shock protein 0.003 0.0147 0.0395
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0173
Leishmania major heat shock protein 83-1 0.0045 0.0256 0.1006
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0078 0.0407
Brugia malayi vesicular acetylcholine transporter unc-17 0.0445 0.3132 1
Trypanosoma cruzi dynamin-1-like protein 0.0023 0.0096 0.0321
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.002 0.0073 0.038
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0209 0.0867
Echinococcus multilocularis snurportin 1 0.0359 0.2513 0.6771
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0036 0.0096
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0164 0.0442
Trichomonas vaginalis dynamin, putative 0.0023 0.0096 0.0516
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0229 0.0616
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0108 0.0901
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0046 0.0051
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0117 0.0769 0.4516
Schistosoma mansoni ran 0.0025 0.0108 0.0292
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0069 0.0184
Trypanosoma brucei heat shock protein, putative 0.0045 0.0256 0.1087
Loa Loa (eye worm) CYP4Cod1 0.0015 0.004 0.0039
Toxoplasma gondii cytochrome p450 superfamily protein 0.0015 0.004 0.033
Toxoplasma gondii Hsp90 domain-containing protein 0.0172 0.1165 0.9704
Giardia lamblia PHD finger protein 15 0.003 0.0144 0.0597
Trypanosoma brucei Sterol methyltransferase, putative 0.0191 0.1306 0.555
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.0256 0.2132
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0159 0.059
Trichomonas vaginalis set domain proteins, putative 0.0245 0.1691 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0398 0.1072
Loa Loa (eye worm) cytochrome P450 0.0015 0.004 0.0039
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0117 0.0769 0.0768
Trichomonas vaginalis interferon-induced GTP-binding protein mx, putative 0.0023 0.0096 0.0516
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0256 0.1039
Echinococcus multilocularis dnaJ subfamily B 0.0419 0.2946 0.7939
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0126 0.0695
Schistosoma mansoni hypothetical protein 0.0024 0.0105 0.0283
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.002 0.0073 0.0196
Leishmania major cytochrome p450-like protein 0.0015 0.004 0.0078
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0398 0.1272
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0445 0.3132 0.3131
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0045 0.0257 0.1093
Loa Loa (eye worm) acetyltransferase 0.0149 0.0999 0.0998
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0218 0.0882
Leishmania major heat shock protein 83-1 0.0045 0.0256 0.1006
Leishmania major cytochrome p450-like protein 0.0015 0.004 0.0078
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0078 0.0407
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0147 0.0393
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.0236 0.092
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0229 0.9585
Onchocerca volvulus 0.0245 0.1691 0.1569
Brugia malayi Endoplasmin precursor 0.0045 0.0256 0.0817
Schistosoma mansoni hypothetical protein 0.0065 0.0398 0.1074
Trypanosoma cruzi heat shock protein, putative 0.003 0.0147 0.0537
Leishmania major geranylgeranyltransferase, putative 0.002 0.0073 0.0223
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0831 0.2239
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.1622 0.4371
Onchocerca volvulus 0.0034 0.0174 0.003
Entamoeba histolytica Ran family GTPase 0.0025 0.0108 0.0422
Echinococcus granulosus dynamin 1 protein 0.0023 0.0096 0.0258
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0445 0.3132 0.3032
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0164 0.137
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.002 0.0073 0.0073
Loa Loa (eye worm) DRP-1 protein 0.0023 0.0096 0.0096
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0256 0.1039
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.032 0.128
Schistosoma mansoni cpg binding protein 0.0096 0.062 0.167
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0078 0.0407
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0191 0.1306 0.551
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.008 0.0683
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0024 0.01 0.0269
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0069 0.022
Trypanosoma cruzi phospholipase A1, putative 0.0337 0.2353 1
Entamoeba histolytica peptidase, C54 family 0.0045 0.0257 0.1044
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0126 0.045
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0147 0.0393
Echinococcus multilocularis dynamin 1 0.0025 0.0109 0.0292
Entamoeba histolytica peptidase, C54 family 0.0117 0.0769 0.318
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0164 0.0443
Schistosoma mansoni hypothetical protein 0.0065 0.0398 0.1074
Echinococcus granulosus heat shock protein 90 0.0045 0.0256 0.0688
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0218 0.0906
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0159 0.0427
Echinococcus multilocularis tar DNA binding protein 0.0125 0.0831 0.2238
Echinococcus multilocularis dynamin 0.0023 0.0096 0.0258
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0172 0.0731
Brugia malayi CXXC zinc finger family protein 0.0091 0.0582 0.186
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0126 0.0695
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0117 0.0769 0.3205
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0195 0.0525
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.004 0.0078
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0034 0.0174 0.0555
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0073

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) > 100 uM Tested for its ability to inhibit calf spleen purine nucleoside phosphorylase (PNP) ChEMBL. 8057293
Ki (binding) > 100 uM Tested for its ability to inhibit calf spleen purine nucleoside phosphorylase (PNP) ChEMBL. 8057293
Ratio (binding) = 7 Ratio of Ki values for guanine and related hypoxanthines in PNP inhibition assay ChEMBL. 8057293

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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