Detailed information for compound 1377294

Basic information

Technical information
  • TDR Targets ID: 1377294
  • Name: 2-[(3-chloro-4-ethoxy-5-methoxyphenyl)methyla mino]-1-phenylethanol hydrochloride
  • MW: 372.286 | Formula: C18H23Cl2NO3
  • H donors: 2 H acceptors: 1 LogP: 3.87 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1c(Cl)cc(cc1OC)CNCC(c1ccccc1)O.Cl
  • InChi: 1S/C18H22ClNO3.ClH/c1-3-23-18-15(19)9-13(10-17(18)22-2)11-20-12-16(21)14-7-5-4-6-8-14;/h4-10,16,20-21H,3,11-12H2,1-2H3;1H
  • InChiKey: NWWXRHSCXRMKBH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(3-chloro-4-ethoxy-5-methoxy-phenyl)methylamino]-1-phenyl-ethanol hydrochloride
  • 2-[(3-chloro-4-ethoxy-5-methoxy-benzyl)amino]-1-phenyl-ethanol hydrochloride
  • 2-[(3-chloro-4-ethoxy-5-methoxybenzyl)amino]-1-phenylethanol hydrochloride
  • MLS000674349
  • SMR000297301

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Mus musculus transient receptor potential cation channel, subfamily C, member 4 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K05328 transient receptor potential cation channel, subfamily C,, putative Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi Transient-receptor-potential like protein Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni transient receptor potential channel Get druggable targets OG5_128782 All targets in OG5_128782
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus transient receptor potential ion channel A Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus multilocularis transient receptor potential ion channel A Get druggable targets OG5_128782 All targets in OG5_128782
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis TRP (transient receptor potential) channel Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus transient receptor potential gamma protein Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus multilocularis transient receptor potential gamma protein Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus TRP transient receptor potential channel Get druggable targets OG5_128782 All targets in OG5_128782
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Short transient receptor potential channel 5, putative Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K05328 transient receptor potential cation channel, subfamily C,, putative Get druggable targets OG5_128782 All targets in OG5_128782
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Short transient receptor potential channel 5, putative Get druggable targets OG5_128782 All targets in OG5_128782
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni transient receptor potential channel 4 Get druggable targets OG5_128782 All targets in OG5_128782
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Transient receptor potential-gamma protein, putative Get druggable targets OG5_128782 All targets in OG5_128782
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis short transient receptor potential channel 6 transient receptor potential cation channel, subfamily C, member 4 890 aa 799 aa 31.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi major facilitator superfamily protein 0.0018 0.0037 0.0036
Loa Loa (eye worm) hypothetical protein 0.0045 0.0178 0.0177
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0043 0.0043
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.0342 0.034
Schistosoma mansoni importin beta-1 0.0035 0.0124 0.0123
Brugia malayi Protein kinase domain containing protein 0.0097 0.0441 0.044
Brugia malayi Cytochrome P450 family protein 0.0028 0.0091 0.009
Echinococcus granulosus Sugar transporter ERD6 protein 0.0018 0.0037 0.0036
Trypanosoma cruzi hexose transporter 0.0039 0.0146 0.0146
Schistosoma mansoni transient receptor potential channel 0.0078 0.0342 0.034
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0172 0.0172
Plasmodium falciparum calcium-dependent protein kinase 1 0.0047 0.0184 0.0572
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0091 0.9938
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0019 0.0043 0.1873
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0047 0.0184 0.0183
Brugia malayi Prion-like- 0.0019 0.0043 0.0042
Plasmodium falciparum protein kinase 6 0.0544 0.2712 1
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0009 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0813 0.4081 0.4058
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0126 0.0589 0.0588
Plasmodium falciparum protein kinase 7 0.0365 0.1801 0.6603
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0019 0.0043 0.3713
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0009 0.0008
Schistosoma mansoni cpg binding protein 0.0037 0.0134 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0009 0.0008
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0009 0.0008
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0186 0.0892 0.0891
Brugia malayi ecdysteroid receptor 0.0012 0.0009 0.0008
Brugia malayi CXXC zinc finger family protein 0.0035 0.0124 0.0123
Echinococcus granulosus epidermal growth factor receptor 0.016 0.0762 0.0761
Loa Loa (eye worm) hypothetical protein 0.0074 0.0322 0.0321
Trypanosoma cruzi glucose transporter, putative 0.0018 0.0037 0.0037
Echinococcus granulosus solute carrier family 22 0.0018 0.0037 0.0036
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0009 0.0008
Plasmodium falciparum calcium-dependent protein kinase 4 0.0047 0.0184 0.0572
Trypanosoma brucei glucose transporter, putative 0.0039 0.0146 0.0146
Leishmania major cytochrome p450-like protein 0.0019 0.0043 0.0043
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0146 0.0146
Trypanosoma brucei sugar transporter, putative 0.0018 0.0037 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0036
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0146 0.0109
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0002 0.0001
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.0091 0.0502
Trypanosoma brucei glucose transporter, putative 0.0039 0.0146 0.0146
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0009 0.0008
Schistosoma mansoni glucose transport protein 0.0126 0.0589 0.0588
Schistosoma mansoni tyrosine kinase 0.0154 0.0731 0.073
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.0589 0.0588
Loa Loa (eye worm) TK/ROR protein kinase 0.0014 0.0021 0.0019
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0037 0.0036
Onchocerca volvulus 0.0018 0.0037 0.0028
Leishmania major cytochrome p450-like protein 0.0019 0.0043 0.0043
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0091 0.0054
Brugia malayi Immunoglobulin domain containing protein 0.0011 0.0001 0.0000069119
Echinococcus granulosus transient receptor potential ion channel A 0.0113 0.0523 0.0522
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0047 0.0184 0.1023
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0001 0.0000069119
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0019 0.0043 0.3713
Echinococcus multilocularis General substrate transporter 0.0108 0.0499 0.0498
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0009 0.0008
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0019 0.0043 0.0042
Brugia malayi Protein kinase domain containing protein 0.0185 0.0886 0.0885
Echinococcus multilocularis peroxidasin 0.0019 0.0045 0.0043
Echinococcus multilocularis 0.0019 0.0043 0.0042
Trypanosoma brucei kinatase, putative 0.0011 0.0001 0.0001
Schistosoma mansoni septate junction protein 0.0019 0.0043 0.0042
Trypanosoma cruzi sugar transporter, putative 0.0018 0.0037 0.0037
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0009 0.0008
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0019 0.0043 0.1873
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0018 0.0037 0.5
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0078 0.0076
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0146 0.0109
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0036
Echinococcus granulosus solute carrier family 22 0.0018 0.0037 0.0036
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.0342 0.034
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0038 0.014 0.0139
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0082 0.0081
Brugia malayi hypothetical protein 0.0018 0.0037 0.0036
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.2459 0.2458
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0031 0.0031
Entamoeba histolytica hypothetical protein 0.0028 0.0091 0.0091
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0019 0.0043 0.3713
Plasmodium falciparum mitogen-activated protein kinase 2 0.0212 0.1025 0.3707
Echinococcus granulosus synaptic vesicle 2 protein 0.0018 0.0037 0.0036
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0018 0.0037 0.2936
Echinococcus multilocularis neuroglian 0.0035 0.0124 0.0123
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0019 0.0043 0.3713
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0014 0.0021 0.0019
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0009 0.0008
Echinococcus multilocularis snurportin 1 0.0372 0.1838 0.1837
Trypanosoma brucei protein kinase, putative 0.0016 0.0031 0.0031
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0021 0.0019
Schistosoma mansoni cpg binding protein 0.0037 0.0134 0.0133
Schistosoma mansoni tyrosine kinase 0.016 0.0762 0.0761
Entamoeba histolytica protein kinase, putative 0.0047 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0038 0.014 0.0139
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0036
Schistosoma mansoni transient receptor potential channel 0.0078 0.0342 0.034
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0027 0.0082 0.0081
Trypanosoma cruzi polo-like protein kinase, putative 0.1977 1 1
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0146 0.0109
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0019 0.0043 0.1873
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0081
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0019 0.0043 0.1873
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0036
Loa Loa (eye worm) TK protein kinase 0.0014 0.0021 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0008
Leishmania major glucose transporter, lmgt1 0.0039 0.0146 0.0146
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0044 0.0172 0.0953
Echinococcus multilocularis epidermal growth factor receptor 0.016 0.0762 0.0761
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0009 0.0008
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0019 0.0043 0.0042
Giardia lamblia Kinase, PLK 0.1977 1 1
Leishmania major protein kinase, putative 0.0016 0.0031 0.0031
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0019 0.0043 0.3713
Trypanosoma cruzi polo-like protein kinase, putative 0.1977 1 1
Trypanosoma brucei polo-like protein kinase 0.1977 1 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.0091 0.0198
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0803 0.4033 0.4032
Schistosoma mansoni titin 0.0019 0.0043 0.0042
Echinococcus multilocularis roundabout 2 0.0019 0.0043 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.1977 1 1
Echinococcus multilocularis epidermal growth factor receptor 0.0294 0.1443 0.1442
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0019 0.0043 0.3713
Schistosoma mansoni vesicular amine transporter 0.003 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.0089
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0081
Loa Loa (eye worm) sugar transporter 0.0018 0.0037 0.0036
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0043 0.0042
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0146 0.0146
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0016 0.0026 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0019 0.0043 0.1873
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0069 1
Onchocerca volvulus 0.0018 0.0037 0.0028
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0018 0.0037 0.0036
Schistosoma mansoni tyrosine kinase 0.0154 0.0731 0.073
Brugia malayi RNA, U transporter 1 0.0099 0.0451 0.045
Schistosoma mansoni protein kinase 0.0016 0.0031 0.003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0009 0.0008
Plasmodium falciparum calcium-dependent protein kinase 3 0.0047 0.0184 0.0572
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.0589 0.0588
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0019 0.0043 0.3713
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0009 0.0008
Echinococcus multilocularis roundabout 2 0.0019 0.0043 0.0042
Onchocerca volvulus 0.0018 0.0037 0.0028
Brugia malayi cytochrome P450 0.0019 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0009 0.0008
Echinococcus granulosus dnaJ subfamily B 0.0494 0.2459 0.2458
Echinococcus multilocularis calcium dependent protein kinase 0.0036 0.0132 0.013
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0009 0.0008
Trypanosoma brucei glucose transporter, putative 0.0039 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0035 0.0124 0.0123
Brugia malayi Transient-receptor-potential like protein 0.0044 0.0169 0.0168
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0009 0.0008
Brugia malayi nuclear receptor NHR-88 0.0012 0.0009 0.0008
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0078 0.0076
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0019 0.0043 0.0042
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0091 0.0053
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0124 0.069
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0091 0.0091
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0019 0.0043 0.0042
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0043 0.0042
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0001 0.0000069119
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0009 0.0008
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0019 0.0043 0.0034
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0019 0.0043 0.1873
Onchocerca volvulus Serine\/threonine kinase homolog 0.1977 1 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0019 0.0043 0.3713
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0081
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.0015 0.5
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0031 0.0031
Plasmodium falciparum proline--tRNA ligase 0.0044 0.0172 0.0525
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0009 0.0008
Plasmodium vivax importin-beta 2, putative 0.0035 0.0124 0.0325
Trypanosoma brucei glucose transporter, putative 0.0039 0.0146 0.0146
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.0043 0.0043
Echinococcus granulosus serine:threonine protein kinase PLK1 0.1977 1 1
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.0342 0.034
Brugia malayi hypothetical protein 0.0018 0.0037 0.0036
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.0091 0.4888
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0091 0.0091
Trichomonas vaginalis CAMK family protein kinase 0.1977 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0008
Onchocerca volvulus 0.0018 0.0037 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0009 0.0008
Echinococcus multilocularis solute carrier family 22 0.0018 0.0037 0.0036
Toxoplasma gondii protein kinase, putative 0.0365 0.1801 1
Onchocerca volvulus 0.0018 0.0037 0.0028
Plasmodium vivax proline--tRNA ligase, putative 0.0044 0.0172 0.0502
Brugia malayi Furin-like cysteine rich region family protein 0.0294 0.1443 0.1443
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0009 0.0008
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0043 0.0042
Onchocerca volvulus 0.0018 0.0037 0.0028
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0009 0.0008
Onchocerca volvulus 0.0483 0.2402 0.2395
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0008
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0091 0.0054
Echinococcus multilocularis titin 0.0019 0.0042 0.0041
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0078 0.004
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0091 0.0054
Schistosoma mansoni glucose transporter 0.0018 0.0037 0.0036
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0019 0.0043 0.1873
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0172 0.0172
Onchocerca volvulus 0.0018 0.0037 0.0028
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0016 0.0031 0.003
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0038 0.014 0.0139
Leishmania major dual specificity protein phosphatase, putative 0.0011 0.0001 0.0001
Echinococcus granulosus TRP transient receptor potential channel 0.0044 0.0169 0.0168
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0047 0.0184 0.0183
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0037 0.0036
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0078 0.0174
Plasmodium vivax calcium-dependent protein kinase, putative 0.0047 0.0184 0.0549
Onchocerca volvulus 0.0018 0.0037 0.0028
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.1977 1 1
Onchocerca volvulus 0.0018 0.0037 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.0589 0.0554
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0009 0.0008
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0019 0.0043 0.1873
Echinococcus granulosus calcium dependent protein kinase 0.0036 0.0132 0.013
Echinococcus granulosus cpg binding protein 0.0037 0.0134 0.0133
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0037 0.0136 0.0135
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0146 0.0146
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0281 0.1562
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0019 0.0043 0.1873
Schistosoma mansoni hypothetical protein 0.0126 0.0589 0.0588
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0047 0.0184 0.0183
Brugia malayi Fibronectin type III domain containing protein 0.0027 0.0082 0.0081
Trichomonas vaginalis CAMK family protein kinase 0.1977 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0009 0.0008
Toxoplasma gondii sugar transporter ST1 0.0018 0.0037 0.0208
Echinococcus granulosus roundabout 2 0.0019 0.0043 0.0042
Toxoplasma gondii transporter, major facilitator family protein 0.0018 0.0037 0.0208
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0037 0.0036
Schistosoma mansoni tyrosine kinase 0.0294 0.1443 0.1442
Echinococcus granulosus titin 0.0019 0.0042 0.0041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0042
Onchocerca volvulus 0.0018 0.0037 0.0028
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0019 0.0043 0.0042
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0019 0.0043 0.0042
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0009 0.0008
Entamoeba histolytica serine/threonine protein kinase, putative 0.1977 1 1
Trypanosoma cruzi kinatase, putative 0.0011 0.0001 0.0001
Schistosoma mansoni protein kinase 0.0047 0.0184 0.0183
Trichomonas vaginalis CAMK family protein kinase 0.1977 1 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0078 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0146 0.0109
Toxoplasma gondii sugar transporter ST3 0.0018 0.0037 0.0208
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0047 0.0184 0.0183
Echinococcus granulosus contactin 0.0019 0.0043 0.0042
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0097 0.0441 0.044
Schistosoma mansoni protein kinase 0.0047 0.0184 0.0183
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.0589 0.0588
Onchocerca volvulus 0.0018 0.0037 0.0028
Brugia malayi protein unc-22 0.0019 0.0042 0.0041
Trypanosoma brucei glucose transporter, putative 0.0039 0.0146 0.0146
Echinococcus multilocularis activin receptor type 0.0016 0.0031 0.003
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0044 0.0169 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.0813 0.4081 0.4058
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0017 0.0033 0.0033
Schistosoma mansoni glucose transport protein 0.0126 0.0589 0.0588
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.0091 0.0222
Schistosoma mansoni tyrosine kinase 0.0097 0.0441 0.044
Loa Loa (eye worm) hypothetical protein 0.0117 0.0543 0.0542
Schistosoma mansoni sugar transporter 0.0018 0.0037 0.0036
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.0091 0.009
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0184 0.0147
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0019 0.0043 0.3713
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0019 0.0043 0.3713
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0001 0.0000069119
Onchocerca volvulus Tyrosine kinase homolog 0.0497 0.2475 0.2468
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0019 0.0043 0.1873
Echinococcus multilocularis hemicentin 1 0.0019 0.0043 0.0042
Echinococcus multilocularis lachesin 0.0019 0.0043 0.0042
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0019 0.0043 0.3713
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0091 0.0091
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0172 0.0172
Echinococcus granulosus lachesin 0.0019 0.0043 0.0042
Trypanosoma brucei glucose transporter, putative 0.0039 0.0146 0.0146
Schistosoma mansoni cell adhesion molecule 0.0019 0.0043 0.0042
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0037 0.0036
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0091 0.0089
Schistosoma mansoni septate junction protein 0.0019 0.0043 0.0042
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0009 0.0008
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0009 0.0008
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0031 0.0031
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0047 0.0184 0.0183
Schistosoma mansoni tyrosine kinase 0.0097 0.0441 0.044
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0091 0.0091
Schistosoma mansoni serine/threonine protein kinase 0.1977 1 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0019 0.0043 0.3713
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0091 0.009
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0146 0.0146
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0078 0.0076
Onchocerca volvulus 0.0019 0.0042 0.0033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0081
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0009 0.0008
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0038 0.014 0.0103
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.1977 1 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0047 0.0184 0.1023
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0009 0.0008
Schistosoma mansoni kinase 0.1967 0.9952 0.9952
Echinococcus granulosus twitchin 0.0045 0.0177 0.0176
Echinococcus multilocularis transient receptor potential ion channel A 0.0113 0.0523 0.0522
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0009 0.0008
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0037 0.0136 0.0135
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0019 0.0043 0.0043
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.0091 0.0053
Schistosoma mansoni hypothetical protein 0.0494 0.2459 0.2458
Entamoeba histolytica Ran family GTPase 0.0026 0.0078 0.0078
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0027 0.0082 0.0081
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.0589 0.0588
Trypanosoma brucei glucose transporter 2A 0.0039 0.0146 0.0146
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0043 0.0042
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0009 0.0008
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0185 0.0886 0.0885
Brugia malayi basement membrane proteoglycan precursor 0.0011 0.0001 0.0000069119
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0047 0.0184 0.0183
Brugia malayi nuclear hormone receptor 0.0012 0.0009 0.0008
Schistosoma mansoni neuroglian 0.0019 0.0043 0.0042
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0019 0.0043 0.0042
Echinococcus multilocularis neuroglian 0.0019 0.0043 0.0042
Plasmodium falciparum hexose transporter 0.0126 0.0589 0.2082
Trypanosoma brucei glucose transporter, putative 0.0039 0.0146 0.0146
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0009 0.0008
Entamoeba histolytica protein kinase, putative 0.0047 0.0184 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0009 0.0008
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0018 0.0037 0.0024
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0038 0.014 0.0139
Echinococcus multilocularis hemicentin 1 0.0019 0.0043 0.0042
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0124 0.0123
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0047 0.0184 0.0183
Onchocerca volvulus 0.0018 0.0037 0.0028
Schistosoma mansoni protein kinase 0.0047 0.0184 0.0183
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0078 0.0077
Schistosoma mansoni tyrosine kinase 0.0025 0.0074 0.0073
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0019 0.0043 0.1873
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0103
Echinococcus granulosus neuroglian 0.0019 0.0043 0.0042
Leishmania major importin beta-1 subunit, putative 0.0028 0.0091 0.0091
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0019 0.0043 0.1873
Brugia malayi hypothetical protein 0.0011 0.0001 0.0000069119
Schistosoma mansoni transient receptor potential channel 0.0117 0.0543 0.0542
Echinococcus granulosus insulin receptor 0.0097 0.0441 0.044
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0036
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0036
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0018 0.0037 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0009 0.0008
Echinococcus multilocularis twitchin 0.0019 0.0042 0.0041
Toxoplasma gondii facilitative glucose transporter GT1 0.0126 0.0589 0.327
Echinococcus granulosus Immunoglobulin 0.0027 0.0082 0.0081
Loa Loa (eye worm) hypothetical protein 0.0047 0.0184 0.0183
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0526 0.2621 0.2621
Loa Loa (eye worm) hypothetical protein 0.0027 0.0083 0.0082
Brugia malayi basement membrane proteoglycan 0.0011 0.0001 0.0000069119
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0078 0.0076
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0047 0.0184 0.0549
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0037 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0042
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0043 0.0042
Echinococcus granulosus roundabout 2 0.0019 0.0043 0.0042
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0009 0.0008
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0001 0.0000069119
Schistosoma mansoni tyrosine kinase 0.016 0.0762 0.0761
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0091 0.009
Plasmodium falciparum calcium-dependent protein kinase 5 0.0047 0.0184 0.0572
Echinococcus granulosus tyrosine protein kinase Lyn 0.0016 0.0031 0.003
Trypanosoma brucei Basal body protein 0.0011 0.0001 0.0001
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0019 0.0043 0.1873
Loa Loa (eye worm) sugar transporter 0.0126 0.0589 0.0588
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.014 0.0139
Trypanosoma cruzi Calcium/calmodulin-dependent protein kinase kinase, putative 0.0011 0.0001 0.0001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0008
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0019 0.0043 0.3713
Onchocerca volvulus Putative transporter 0.0018 0.0037 0.0028
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0019 0.0043 0.3713
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0029 0.0096 0.0095
Trypanosoma cruzi Calcium/calmodulin-dependent protein kinase kinase, putative 0.0011 0.0001 0.0001
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0146 0.0109
Schistosoma mansoni cell adhesion molecule 0.0019 0.0043 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0009 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.1977 1 1
Schistosoma mansoni protein kinase 0.0016 0.0031 0.003
Brugia malayi Sugar transporter family protein 0.0018 0.0037 0.0036
Schistosoma mansoni coup transcription factor 0.0012 0.0009 0.0008
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.0091 0.0089
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0097 0.0441 0.044
Leishmania major cytochrome p450-like protein 0.0028 0.0091 0.0091
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0019 0.0043 0.1873
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0019 0.0043 0.1873
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0009 0.0008
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0321 0.032
Brugia malayi hypothetical protein 0.0027 0.0082 0.0081
Chlamydia trachomatis lysine--tRNA ligase 0.0028 0.0091 1
Schistosoma mansoni tyrosine kinase 0.0154 0.0731 0.073
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0081
Entamoeba histolytica protein kinase domain containing protein 0.0016 0.0031 0.0031
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0027 0.0082 0.0081
Echinococcus granulosus importin subunit beta 1 0.0035 0.0124 0.0123
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0042
Brugia malayi Sugar transporter family protein 0.0126 0.0589 0.0588
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0002 0.0001
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.1838 0.1837
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0008
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0047 0.0184 0.0549
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0073 0.0035
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0018 0.0037 0.2936
Schistosoma mansoni titin 0.0019 0.0042 0.0041
Giardia lamblia Prolyl-tRNA synthetase 0.0038 0.014 0.0103
Leishmania major glucose transporter/membrane transporter D2, putative 0.0039 0.0146 0.0146
Schistosoma mansoni roundabout 0.0019 0.0043 0.0042
Echinococcus granulosus snurportin 1 0.0372 0.1838 0.1837
Trypanosoma cruzi kinatase, putative 0.0011 0.0001 0.0001
Echinococcus multilocularis cpg binding protein 0.0037 0.0134 0.0133
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0008
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0019 0.0043 0.1873
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0036
Brugia malayi Sugar transporter family protein 0.0018 0.0037 0.0036
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0036
Brugia malayi lysyl-tRNA synthetase 0.0028 0.0091 0.0089
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.0342 0.034
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0042 0.0041
Echinococcus multilocularis solute carrier family 22 0.0018 0.0037 0.0036
Onchocerca volvulus 0.0018 0.0037 0.0028
Echinococcus granulosus General substrate transporter 0.0108 0.0499 0.0498
Echinococcus granulosus tyrosine protein kinase otk 0.0019 0.0043 0.0042
Brugia malayi Cytochrome P450 family protein 0.0028 0.0091 0.009
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0019 0.0043 0.3713
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0019 0.0043 0.1873
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0019 0.0043 0.1873
Loa Loa (eye worm) hypothetical protein 0.0045 0.0178 0.0177
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.1977 1 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0019 0.0043 0.0042
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0043 0.0042
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0043 0.0042
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0043 0.0042
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0212 0.1025 0.569
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0019 0.0043 0.0043
Mycobacterium ulcerans sugar transporter 0.0018 0.0037 0.2936
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0047 0.0184 0.0183
Echinococcus granulosus activin receptor type 0.0016 0.0031 0.003
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0038 0.014 0.014
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0146 0.0146
Loa Loa (eye worm) TK/INSR protein kinase 0.0097 0.0441 0.044
Echinococcus granulosus calcium activated potassium channel 0.0014 0.002 0.0019
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.0091 0.009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0009 0.0008
Leishmania major glucose transporter, lmgt2 0.0039 0.0146 0.0146
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0042 0.0041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0009 0.0008
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0124 0.0122
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0019 0.0043 0.1873
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0036
Schistosoma mansoni ran 0.0026 0.0078 0.0076
Plasmodium vivax CDK-related protein kinase 6, putative 0.0544 0.2712 1
Schistosoma mansoni cytochrome P450 0.0019 0.0043 0.0042
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0124 0.0124
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0024 0.0069 1
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0009 0.0008
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0019 0.0043 0.3713
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0019 0.0043 0.3713
Echinococcus multilocularis transient receptor potential gamma protein 0.0117 0.0543 0.0542
Brugia malayi Importin beta-1 subunit 0.0035 0.0124 0.0123
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0056 0.0056
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.0589 0.0588
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0019 0.0042 0.0041
Leishmania major myo-inositol/proton symporter (MIT) 0.0018 0.0037 0.0037
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0078 0.015
Echinococcus granulosus defective proboscis extension response 0.0027 0.0082 0.0081
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0009 0.0008
Schistosoma mansoni cell adhesion molecule 0.0019 0.0043 0.0042
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0091 1
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0019 0.0043 0.3713
Brugia malayi Immunoglobulin I-set domain containing protein 0.0526 0.2621 0.2621
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0036
Mycobacterium ulcerans integral membrane transport protein 0.0018 0.0037 0.2936
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0009 0.0008
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0091 0.0089
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0047 0.0184 0.0549
Echinococcus multilocularis insulin receptor 0.0097 0.0441 0.044
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0019 0.0043 0.3713
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0018 0.0037 0.0037
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0078 0.043
Loa Loa (eye worm) hypothetical protein 0.0038 0.014 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0009 0.0008
Brugia malayi Heparan sulfate 0.0011 0.0001 0.0000069119
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0009 0.0008
Schistosoma mansoni hypothetical protein 0.0019 0.0043 0.0042
Schistosoma mansoni ran 0.0026 0.0078 0.0076
Brugia malayi major facilitator superfamily protein 0.0018 0.0037 0.0036
Echinococcus granulosus solute carrier family 22 0.0018 0.0037 0.0036
Schistosoma mansoni cell adhesion molecule 0.0037 0.0136 0.0135
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0047 0.0184 0.0183
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0038 0.014 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.0589 0.0588
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0042
Echinococcus granulosus roundabout 2 0.0045 0.0178 0.0177
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0014 0.0021 0.0019
Echinococcus multilocularis 0.009 0.0403 0.0402
Echinococcus multilocularis Immunoglobulin 0.0027 0.0082 0.0081
Echinococcus granulosus titin 0.0019 0.0042 0.0041
Schistosoma mansoni nephrin 0.0019 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0019 0.0045 0.0043
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0009 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0146 0.0109
Brugia malayi steroid hormone receptor 0.0012 0.0009 0.0008
Echinococcus granulosus transient receptor potential gamma protein 0.0117 0.0543 0.0542
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0042
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0016 0.0031 0.0172
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0009 0.0008
Schistosoma mansoni protein kinase 0.0016 0.0031 0.003
Echinococcus granulosus epidermal growth factor receptor 0.0294 0.1443 0.1442
Echinococcus granulosus neuroglian 0.0035 0.0124 0.0123
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0009 0.0008
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0019 0.0043 0.0042
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0185 0.0886 0.0885
Echinococcus multilocularis synaptic vesicle 2 protein 0.0018 0.0037 0.0036
Onchocerca volvulus 0.0018 0.0037 0.0028
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0038 0.014 0.0139
Leishmania major hypothetical protein, conserved 0.0018 0.0037 0.0037
Echinococcus multilocularis solute carrier family 22 0.0018 0.0037 0.0036
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0047 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.004 0.0149 0.0148
Loa Loa (eye worm) cytochrome P450 0.0019 0.0043 0.0042
Trypanosoma brucei glucose transporter, putative 0.0039 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0042
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0037 0.0037
Schistosoma mansoni sugar transporter 0.0018 0.0037 0.0036
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0078 0.0077
Schistosoma mansoni sugar transporter 0.0018 0.0037 0.0036
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.0091 0.009
Plasmodium falciparum calcium-dependent protein kinase 2 0.0047 0.0184 0.0572
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0091 0.009
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0043 0.0043
Trypanosoma brucei glucose transporter 1E 0.0039 0.0146 0.0146
Onchocerca volvulus 0.0018 0.0037 0.0028
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0036
Trichomonas vaginalis ran, putative 0.0026 0.0078 0.004
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0036
Echinococcus granulosus peroxidasin 0.0019 0.0045 0.0043
Plasmodium vivax hexose transporter 0.0126 0.0589 0.2063
Brugia malayi Peroxidasin 0.0019 0.0045 0.0044
Leishmania major protein kinase, putative 0.0047 0.0184 0.0184
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0047 0.0184 0.1023
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0047 0.0184 0.0183
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0184 0.0183
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.014 0.0139
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.016 0.0762 0.0761
Loa Loa (eye worm) TK/EGFR protein kinase 0.0294 0.1443 0.1442
Echinococcus multilocularis tyrosine protein kinase otk 0.0019 0.0043 0.0042
Echinococcus multilocularis calcium activated potassium channel 0.0014 0.002 0.0019
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.0043 0.0042
Toxoplasma gondii sugar transporter ST2 0.0018 0.0037 0.0208
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0009 0.0008
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0002 0.0001
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0124 0.0124
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0212 0.1025 0.3692
Plasmodium falciparum importin beta, putative 0.0035 0.0124 0.0348
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0069 0.2648
Echinococcus multilocularis solute carrier family 22 0.0018 0.0037 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.1977 1 1
Echinococcus multilocularis roundabout 2 0.0045 0.0178 0.0177
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0042
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.0589 0.0588
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0036
Brugia malayi Cytochrome P450 family protein 0.0019 0.0043 0.0042
Echinococcus granulosus hemicentin 1 0.0019 0.0043 0.0042
Schistosoma mansoni sugar transporter 0.0018 0.0037 0.0036
Leishmania major GTP-binding protein, putative 0.0026 0.0078 0.0077
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0002 0.0001
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0251 0.025
Brugia malayi Immunoglobulin domain containing protein 0.0011 0.0001 0.0000069119
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.0043 0.024
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0172 0.0172
Onchocerca volvulus 0.0035 0.0124 0.0114
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0047 0.0184 0.0183
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0146 0.0109
Trichomonas vaginalis CAMK family protein kinase 0.1977 1 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0019 0.0043 0.1873
Brugia malayi Cam kinase protein 1 0.0047 0.0184 0.0183
Schistosoma mansoni nephrin 0.0035 0.0124 0.0123
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0019 0.0043 0.3713
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0172 0.0172
Schistosoma mansoni cpg binding protein 0.0035 0.0124 0.0122
Leishmania major glucose transporter, lmgt3 0.0039 0.0146 0.0146
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0016 0.0031 0.003
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.0091 0.0089
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.0036
Onchocerca volvulus 0.0018 0.0037 0.0028
Entamoeba histolytica hypothetical protein 0.0028 0.0091 0.0091
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0009 0.0008
Brugia malayi Cytochrome P450 family protein 0.006 0.0251 0.025
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0009 0.0008
Loa Loa (eye worm) CAMK protein kinase 0.0019 0.0042 0.0041
Loa Loa (eye worm) hypothetical protein 0.0044 0.0169 0.0168
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0091 0.9938
Schistosoma mansoni glucose transport protein 0.0126 0.0589 0.0588
Schistosoma mansoni transient receptor potential channel 4 0.0117 0.0543 0.0542
Brugia malayi hypothetical protein 0.0018 0.0037 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0009 0.0008
Echinococcus granulosus solute carrier family 22 0.0018 0.0037 0.0036
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0019 0.0043 0.0042
Schistosoma mansoni hypothetical protein 0.0372 0.1838 0.1837
Brugia malayi Immunoglobulin domain containing protein 0.0011 0.0001 0.0000069119
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0042 0.0041
Schistosoma mansoni peroxidasin 0.0011 0.0002 0.0001
Echinococcus multilocularis Immunoglobulin 0.0027 0.0082 0.0081
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0803 0.4033 0.4032

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 2.1133 uM PUBCHEM_BIOASSAY: Confirmation dose response assay for compounds that inhibit transient receptor potential cation channel C4 (TRPC4). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2247, AID2256] ChEMBL. No reference
Potency (functional) 0.6513 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 70.7946 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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