Detailed information for compound 1379116

Basic information

Technical information
  • TDR Targets ID: 1379116
  • Name: N-tert-butyl-2-[[2-[5-(4-fluorophenyl)tetrazo l-2-yl]acetyl]-(2-methylphenyl)amino]-2-pyrid in-4-ylacetamide
  • MW: 501.555 | Formula: C27H28FN7O2
  • H donors: 1 H acceptors: 6 LogP: 4.39 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: Fc1ccc(cc1)c1nnn(n1)CC(=O)N(C(C(=O)NC(C)(C)C)c1ccncc1)c1ccccc1C
  • InChi: 1S/C27H28FN7O2/c1-18-7-5-6-8-22(18)35(24(19-13-15-29-16-14-19)26(37)30-27(2,3)4)23(36)17-34-32-25(31-33-34)20-9-11-21(28)12-10-20/h5-16,24H,17H2,1-4H3,(H,30,37)
  • InChiKey: NWQONXIHQZFPDH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-tert-butyl-2-[[2-[5-(4-fluorophenyl)tetrazol-2-yl]acetyl]-(2-methylphenyl)amino]-2-(4-pyridyl)acetamide
  • N-tert-butyl-2-[[2-[5-(4-fluorophenyl)-2-tetrazolyl]-1-oxoethyl]-(2-methylphenyl)amino]-2-(4-pyridyl)acetamide
  • N-tert-butyl-2-[2-[5-(4-fluorophenyl)-1,2,3,4-tetrazol-2-yl]ethanoyl-(2-methylphenyl)amino]-2-pyridin-4-yl-ethanamide
  • SMR000278587
  • ASN 03862166
  • MLS000717220

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0238 0.0832
Echinococcus multilocularis Smad4 0.0027 0.0082 0.0081
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0238 0.0895
Schistosoma mansoni intermediate filament proteins 0.0032 0.0112 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.0137 0.0809 0.3044
Giardia lamblia Sgs1 DNA helicase, putative 0.0056 0.0273 0.0333
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0328 0.1232
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0018 0.0018 0.0019
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0042 0.018 0.0182
Echinococcus granulosus intermediate filament protein 0.0032 0.0112 0.0111
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0056 0.0273 0.0964
Echinococcus multilocularis FTZ F1 alpha 0.003 0.01 0.01
Brugia malayi glutaminase DH11.1 0.027 0.1694 0.2339
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0025 0.0095
Loa Loa (eye worm) hypothetical protein 0.0029 0.009 0.0223
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.01 0.0247
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0088 0.0482 0.1811
Entamoeba histolytica hypothetical protein 0.0079 0.0421 0.0527
Trypanosoma brucei DNA polymerase kappa, putative 0.0137 0.0809 0.3044
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0171 0.0643
Loa Loa (eye worm) hypothetical protein 0.0149 0.0887 0.2204
Echinococcus multilocularis muscleblind protein 1 0.0621 0.4023 0.4099
Brugia malayi RNA binding protein 0.0138 0.0815 0.1125
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0082 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.01 0.0137
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0333 0.2108 0.2735
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0247
Loa Loa (eye worm) calpain 5 0.0019 0.0025 0.0061
Loa Loa (eye worm) calpain 0.0019 0.0025 0.0061
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0038 0.0111
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0063 0.0319 0.1138
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0067 0.0342 0.0349
Onchocerca volvulus 0.0523 0.3372 0.3315
Brugia malayi ImpB/MucB/SamB family protein 0.0105 0.0599 0.0826
Brugia malayi Disco-interacting protein 2 homolog 0.0038 0.0153 0.021
Brugia malayi MH2 domain containing protein 0.0027 0.0082 0.0112
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0025 0.0095
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0141 0.0531
Schistosoma mansoni hypothetical protein 0.0069 0.0357 0.0364
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0082 0.0081
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0086 0.0284
Trypanosoma brucei DNA polymerase kappa, putative 0.0137 0.0809 0.3044
Echinococcus granulosus bloom syndrome protein 0.0103 0.0582 0.0591
Mycobacterium ulcerans DNA polymerase IV 0.0137 0.0809 0.4655
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0155 0.0764
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.035 0.0354
Loa Loa (eye worm) MBCTL1 0.0118 0.068 0.1689
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0131 0.0772 0.2905
Brugia malayi CHD4 protein 0.0018 0.0022 0.0029
Brugia malayi isocitrate dehydrogenase 0.0032 0.0109 0.015
Echinococcus multilocularis cpg binding protein 0.0131 0.0772 0.0785
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0109 0.0345
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0006 0.0007
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0113 0.0647 0.2434
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0082 0.0202
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.013 0.0131
Onchocerca volvulus 0.0044 0.0191 0.0106
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0238 0.024
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0647 0.3513
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.0421 0.0429
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0171 0.0471
Echinococcus multilocularis protein quaking 0.0027 0.0082 0.0081
Toxoplasma gondii hypothetical protein 0.0084 0.0455 0.1655
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0029 0.0092 0.0278
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0069 0.0357 0.0362
Entamoeba histolytica hypothetical protein 0.0079 0.0421 0.0527
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0039 0.5
Giardia lamblia Kinase, PLK 0.0113 0.0647 0.0822
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0082 0.0081
Entamoeba histolytica recQ family DNA helicase 0.0029 0.009 0.0094
Brugia malayi F/Y-rich N-terminus family protein 0.0042 0.0176 0.0242
Giardia lamblia Flap structure-specific endonuclease 0.0088 0.0482 0.0606
Loa Loa (eye worm) hypothetical protein 0.0038 0.0153 0.0379
Schistosoma mansoni DNA helicase recq1 0.0056 0.0273 0.0278
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0018 0.0018 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.01 0.0137
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0028 0.0086 0.0212
Loa Loa (eye worm) RNA binding protein 0.0138 0.0815 0.2026
Brugia malayi XPG I-region family protein 0.0018 0.0018 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0106
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.0103 0.0103
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0039 0.0078
Schistosoma mansoni smad1 5 8 and 0.0027 0.0082 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.01 0.0137
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0395 0.0403
Schistosoma mansoni hypothetical protein 0.0304 0.192 0.1957
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0048 0.0167
Echinococcus multilocularis calpain family protein 1, d 0.0045 0.0195 0.0197
Schistosoma mansoni bromodomain containing protein 0.0071 0.0373 0.038
Plasmodium falciparum flap endonuclease 1 0.0088 0.0482 0.1754
Schistosoma mansoni inositol monophosphatase 0.0036 0.0141 0.0144
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0016 0.0005 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0112 0.0522
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.01 0.01
Brugia malayi jmjC domain containing protein 0.0042 0.0177 0.0244
Brugia malayi calpain family protein 1 0.0063 0.0321 0.0442
Entamoeba histolytica recQ family helicase, putative 0.0066 0.0337 0.0417
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0171 0.02
Brugia malayi SET domain containing protein 0.0016 0.0004 0.0004
Echinococcus granulosus DNA methyltransferase 2, putative 0.002 0.003 0.0028
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.01 0.0309
Trypanosoma brucei calpain-like protein, putative 0.0131 0.0772 0.2905
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.01 0.01
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0011 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0328 0.1232
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0117 0.044
Trypanosoma cruzi DNA damage repair protein, putative 0.0033 0.0117 0.044
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.01 0.0247
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0415 0.2655 0.2704
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0171 0.0172
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0096
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.01 0.0309
Echinococcus granulosus protein quaking 0.0027 0.0082 0.0081
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0028 0.0083 0.0245
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.01 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0434 0.1633
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0067 0.0342 0.0346
Leishmania major importin beta-1 subunit, putative 0.0023 0.0054 0.0202
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0141 0.0687
Echinococcus granulosus lamin dm0 0.0032 0.0112 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0081 0.0348
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0086 0.0118
Loa Loa (eye worm) hypothetical protein 0.0028 0.0086 0.0212
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0118 0.068 0.0939
Brugia malayi mbt repeat family protein 0.0103 0.0585 0.0808
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.009 0.0223
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0011 0.0012
Schistosoma mansoni kinase 0.0058 0.0283 0.0288
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0086 0.0324
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0109 0.0109
Trypanosoma brucei DNA repair protein RAD2, putative 0.0018 0.0018 0.0069
Schistosoma mansoni blooms syndrome DNA helicase 0.0029 0.009 0.0092
Leishmania major hypothetical protein, conserved 0.003 0.01 0.0376
Echinococcus granulosus neuropeptide s receptor 0.0546 0.3525 0.3591
Schistosoma mansoni hypothetical protein 0.0032 0.0115 0.0117
Schistosoma mansoni hypothetical protein 0.0069 0.0357 0.0364
Brugia malayi hypothetical protein 0.003 0.01 0.0137
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0131 0.0772 0.2905
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0109 0.0109
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0647 0.3513
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0113 0.0651 0.6788
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.01 0.0137
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.002 0.003 0.0043
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0038 0.0155 0.0384
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.01 0.0102
Echinococcus granulosus BRK domain containing protein 0.0025 0.0068 0.0067
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0056 0.0273 0.0276
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0863 0.0879
Loa Loa (eye worm) histone methyltransferase 0.0031 0.0103 0.0255
Schistosoma mansoni ap endonuclease 0.0041 0.0171 0.0174
Echinococcus granulosus chromobox protein 1 0.0069 0.0355 0.0359
Entamoeba histolytica hypothetical protein 0.0023 0.0054 0.0046
Leishmania major DNA polymerase kappa, putative 0.0033 0.0117 0.044
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0041 0.0169 0.0571
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0141 0.0142
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0013 0.0018
Trypanosoma cruzi DNA polymerase eta, putative 0.0063 0.0319 0.1199
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.01 0.01
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0273 0.1422
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0355 0.1881
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0247
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0018 0.0069
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0086 0.0284
Leishmania major DNA damage repair protein, putative 0.0033 0.0117 0.044
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0141 0.0687
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0093 0.0518 0.1893
Trichomonas vaginalis DNA helicase recq, putative 0.0066 0.0337 0.1781
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0106
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0247
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.01 0.01
Echinococcus multilocularis peregrin 0.0046 0.0207 0.0209
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.01 0.0014
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0293 0.0727
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0074 0.039 0.0968
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0815 0.0831
Plasmodium falciparum phd finger protein, putative 0.0029 0.009 0.0273
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0135 0.0135
Echinococcus multilocularis zinc finger protein 0.0028 0.0088 0.0087
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0009 0.0006
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0171 1
Trypanosoma brucei DNA damage repair protein, putative 0.0033 0.0117 0.044
Echinococcus multilocularis chromobox protein 1 0.0069 0.0355 0.0359
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0247
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0247
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0082 0.0083
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0131 0.0772 0.2905
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0056 0.0273 0.0276
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0025 0.0066 0.0065
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0109 0.015
Schistosoma mansoni DNA polymerase IV / kappa 0.0033 0.0117 0.0119
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0117 0.0117
Echinococcus multilocularis snurportin 1 0.0304 0.192 0.1955
Brugia malayi hypothetical protein 0.0079 0.0421 0.0581
Echinococcus multilocularis global transcription activator snf2l2 0.0148 0.0883 0.0898
Schistosoma mansoni lozenge 0.0066 0.0336 0.0342
Echinococcus granulosus Chromo domain 0.0036 0.0142 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0048 0.0167
Plasmodium vivax DEAD/DEAH helicase, putative 0.0023 0.0051 0.0123
Onchocerca volvulus Serine\/threonine kinase homolog 0.0113 0.0647 0.0566
Schistosoma mansoni cpg binding protein 0.0131 0.0772 0.0787
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.009 0.0092
Brugia malayi TAR-binding protein 0.0138 0.0815 0.1125
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0025 0.0095
Echinococcus multilocularis microtubule associated protein 2 0.1494 0.9812 1
Toxoplasma gondii exonuclease III APE 0.0041 0.0171 0.0578
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0025 0.0095
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.002 0.003 0.0043
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0054 0.0202
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0082 0.0081
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0177 0.0181
Echinococcus multilocularis hypothetical protein 0.0019 0.0025 0.0023
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0069 0.0357 0.0492
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.01 0.0247
Toxoplasma gondii RNA-directed DNA polymerase 0.0416 0.2659 1
Loa Loa (eye worm) tumor suppressor 0.0324 0.2047 0.5088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0863 0.0879
Echinococcus granulosus calpain 0.0019 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0029 0.0089 0.0221
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0025 0.0095
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0238 0.1228
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0838 0.3152
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0013
Trypanosoma cruzi kinesin, putative 0.0019 0.0025 0.0095
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0029 0.009 0.0339
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.01 0.0137
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0056 0.0273 0.0276
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0171 0.0643
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0096
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0074 0.039 0.1467
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0647 0.3513
Mycobacterium ulcerans DNA polymerase IV 0.0137 0.0809 0.4655
Brugia malayi Bloom's syndrome protein homolog 0.0103 0.0582 0.0803
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.01 0.01
Echinococcus granulosus lamin 0.0032 0.0112 0.0111
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.01 0.01
Brugia malayi MH2 domain containing protein 0.0402 0.2565 0.3542
Schistosoma mansoni hypothetical protein 0.0027 0.0082 0.0083
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.0421 0.0427
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0109 0.027
Loa Loa (eye worm) calpain family protein 1 0.0063 0.0321 0.0795
Echinococcus multilocularis polycomb protein SCMH1 0.0103 0.0585 0.0594
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.01 0.0247
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0054 0.0197
Brugia malayi Associated with TFs and helicases family protein 0.0036 0.0142 0.0195
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0013
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0025 0.0095
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0815 0.0831
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0029 0.009 0.0339
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0141 0.0531
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0086 0.0118
Plasmodium vivax flap endonuclease 1, putative 0.0088 0.0482 0.1754
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0074 0.039 0.1467
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0109 0.0345
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0131 0.0772 0.2905
Brugia malayi Pre-SET motif family protein 0.0033 0.0117 0.0161
Schistosoma mansoni myelin transcription factor 1 myt1 0.0118 0.068 0.0693
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0238 0.024
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.0832 0.877
Loa Loa (eye worm) mbt repeat family protein 0.0103 0.0585 0.1454
Trypanosoma brucei exonuclease, putative 0.0018 0.0018 0.0069
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0025 0.0026
Trichomonas vaginalis STE family protein kinase 0.0074 0.039 0.2077
Brugia malayi SET domain containing protein 0.0016 0.0005 0.0007
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.0832 1
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0113 0.0647 0.2434
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0171 0.0853
Loa Loa (eye worm) hypothetical protein 0.007 0.0362 0.0897
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0112 0.0522
Loa Loa (eye worm) hypothetical protein 0.0051 0.0239 0.0591
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0088 0.0482 0.1754
Loa Loa (eye worm) hypothetical protein 0.0118 0.068 0.1689
Echinococcus multilocularis BRK domain containing protein 0.0025 0.0068 0.0067
Brugia malayi CXXC zinc finger family protein 0.0124 0.0725 0.1001
Plasmodium vivax calpain, putative 0.0019 0.0025 0.0026
Onchocerca volvulus 0.0038 0.0153 0.0067
Giardia lamblia Kinase, STE STE20 0.0074 0.039 0.0486
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0112 0.0276
Loa Loa (eye worm) hypothetical protein 0.0523 0.3372 0.8382
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0081 0.0348
Brugia malayi intermediate filament protein 0.0032 0.0112 0.0153
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0179 0.0673
Schistosoma mansoni thyroid hormone receptor 0.003 0.01 0.0102
Loa Loa (eye worm) hypothetical protein 0.0136 0.0801 0.1988
Plasmodium falciparum telomerase reverse transcriptase 0.0416 0.2659 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.0103 0.0103
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0066 0.0337 0.1267
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0171 0.02
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.01 0.0137
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0218 0.1344 0.334
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0238 0.0895
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.01 0.0137
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.01 0.0376
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0067 0.0342 0.0349
Echinococcus multilocularis dnaJ subfamily B 0.1299 0.8521 0.8684
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0056 0.0273 0.0376
Echinococcus granulosus dual specificity mitogen activated protein 0.0074 0.039 0.0395
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1807 1
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0238 0.024
Loa Loa (eye worm) flap endonuclease-1 0.0088 0.0482 0.1196
Echinococcus granulosus polycomb protein SCMH1 0.0103 0.0585 0.0594
Plasmodium vivax SET domain protein, putative 0.0033 0.0117 0.0373
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.01 0.01
Entamoeba histolytica protein kinase, putative 0.002 0.0034 0.002
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0086 0.0324
Loa Loa (eye worm) BRM protein 0.0093 0.0518 0.1286
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0228 0.023
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.024 0.0902
Brugia malayi MH1 domain containing protein 0.0027 0.0082 0.0112
Echinococcus granulosus disco interacting protein 2 0.0039 0.0161 0.0161
Leishmania major mitochondrial DNA polymerase beta 0.0299 0.1882 0.7078
Loa Loa (eye worm) hypothetical protein 0.0018 0.0018 0.0044
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0086 0.0118
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.117 0.7661 1
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0112 0.0276
Loa Loa (eye worm) hypothetical protein 0.0044 0.0192 0.0475
Echinococcus multilocularis BRK domain containing protein 0.0025 0.0068 0.0067
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0082 0.0202
Brugia malayi nuclear receptor NHR-88 0.003 0.01 0.0137
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0247
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0355 0.088
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0066 0.0335 0.1201
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.01 0.01
Schistosoma mansoni cpg binding protein 0.0131 0.0772 0.0787
Schistosoma mansoni sex comb on midleg homolog 0.0103 0.0585 0.0597
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.01 0.0137
Loa Loa (eye worm) hypothetical protein 0.0063 0.0321 0.0795
Loa Loa (eye worm) CXXC zinc finger family protein 0.0124 0.0725 0.1802
Echinococcus multilocularis Protein lozenge 0.0066 0.0336 0.034
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0113 0.0647 0.2434
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0113 0.0647 0.0657
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0103 0.0585 0.0504
Brugia malayi MH2 domain containing protein 0.0027 0.0082 0.0112
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0025 0.0095
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0069 0.0357 0.0362
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0815 0.0831
Loa Loa (eye worm) runx1 0.0066 0.0336 0.0833
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.01 0.0309
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0006 0.0004
Brugia malayi ecdysteroid receptor 0.003 0.01 0.0137
Brugia malayi hypothetical protein 0.0019 0.0029 0.0039
Loa Loa (eye worm) hypothetical protein 0.0029 0.009 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.0137 0.0809 0.3044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1807 1
Trypanosoma brucei protein kinase, putative 0.0051 0.0238 0.0895
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.002 0.003 0.0015
Trypanosoma brucei DNA polymerase IV, putative 0.0137 0.0809 0.3044
Giardia lamblia DNA repair protein RAD52 0.117 0.7661 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0103 0.0585 0.0597
Brugia malayi Muscleblind-like protein 0.0621 0.4023 0.5556
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0415 0.2655 0.2704
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0141 0.0142
Trypanosoma cruzi kinesin, putative 0.0019 0.0025 0.0095
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.01 0.01
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0171 0.0853
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0838 0.3152
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0117 0.044
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0238 0.059
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0086 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0434 0.1633
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0137 0.0809 0.4422
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0086 0.0284
Trypanosoma cruzi DNA polymerase kappa, putative 0.0137 0.0809 0.3044
Brugia malayi Bromodomain containing protein 0.0042 0.0176 0.0242
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0105 0.0599 0.061
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.009 0.0272
Onchocerca volvulus 0.0103 0.0585 0.0504
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.009 0.0273
Echinococcus multilocularis SAM and MBT domain containing protein 0.0103 0.0585 0.0594
Entamoeba histolytica hypothetical protein 0.0079 0.0421 0.0527
Onchocerca volvulus Bile acid receptor homolog 0.003 0.01 0.0014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0003 0.0003
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0131 0.0772 0.2905
Echinococcus granulosus global transcription activator snf2l2 0.0148 0.0883 0.0898
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0863 0.0877
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1807 1
Onchocerca volvulus 0.0236 0.1468 0.1394
Brugia malayi tumor suppressor. 0.0324 0.2047 0.2826
Schistosoma mansoni nuclear hormone receptor 0.003 0.01 0.0102
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.0863 0.119
Echinococcus granulosus importin subunit beta 1 0.0029 0.0089 0.0089
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0082 0.0081
Brugia malayi RNA, U transporter 1 0.0081 0.0438 0.0604
Echinococcus multilocularis geminin 0.0338 0.2143 0.2183
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0647 0.3513
Schistosoma mansoni phd finger protein 0.0018 0.0017 0.0017
Echinococcus granulosus zinc finger protein 0.0028 0.0088 0.0087
Echinococcus multilocularis DNA methyltransferase 2, putative 0.002 0.003 0.0028
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.0421 0.0427
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0109 0.0345
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0023 0.0051 0.0123
Echinococcus multilocularis lamin dm0 0.0032 0.0112 0.0111
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0056 0.0273 0.0276
Entamoeba histolytica hypothetical protein 0.0079 0.0421 0.0527
Schistosoma mansoni terminal deoxycytidyl transferase 0.0105 0.0599 0.061
Brugia malayi Latrophilin receptor protein 2 0.0069 0.0357 0.0492
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0117 0.044
Schistosoma mansoni glutaminase 0.027 0.1694 0.1726
Loa Loa (eye worm) hypothetical protein 0.0063 0.0321 0.0795
Schistosoma mansoni inositol monophosphatase 0.0036 0.0141 0.0144
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.01 0.01
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0228 0.0233
Trypanosoma cruzi DNA polymerase kappa, putative 0.0137 0.0809 0.3044
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0106
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0025 0.0023
Schistosoma mansoni hypothetical protein 0.002 0.0035 0.0035
Trypanosoma brucei kinesin, putative 0.0019 0.0025 0.0095
Loa Loa (eye worm) RecQ helicase 0.0103 0.0582 0.1446
Echinococcus multilocularis calpain 5 0.0019 0.0025 0.0023
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0416 0.2659 1
Brugia malayi polk-prov protein 0.0064 0.0328 0.0452
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0135 0.0135
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0086 0.0598
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0025 0.0095
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.01 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.0137 0.0809 0.3044
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0117 0.0119
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.009 0.009
Onchocerca volvulus 0.003 0.01 0.0014
Echinococcus granulosus dna polymerase eta 0.0136 0.0801 0.0814
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.01 0.0309
Plasmodium vivax hypothetical protein, conserved 0.0029 0.009 0.0273
Echinococcus multilocularis neuropeptide receptor A26 0.0546 0.3525 0.3591
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0018 0.0069
Loa Loa (eye worm) hypothetical protein 0.0064 0.0328 0.0813
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0084 0.0455 0.1655
Echinococcus granulosus dna polymerase kappa 0.0137 0.0809 0.0823
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0082 0.0081
Brugia malayi Bromodomain containing protein 0.0035 0.0131 0.0181
Toxoplasma gondii hypothetical protein 0.0048 0.022 0.0763
Schistosoma mansoni hypothetical protein 0.0029 0.009 0.0092
Leishmania major DNA polymerase eta, putative 0.0136 0.0801 0.3011
Trichomonas vaginalis flap endonuclease-1, putative 0.0088 0.0482 0.259
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0011 0.0012
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0523 0.0531
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.01 0.0102
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0109 0.0109
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0086 0.0284
Echinococcus multilocularis exonuclease 1 0.0018 0.0018 0.0016
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0118 0.068 0.0691
Brugia malayi hypothetical protein 0.0016 0.0006 0.0007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0171 0.0643
Plasmodium vivax importin-beta 2, putative 0.0029 0.0089 0.0269
Echinococcus granulosus microtubule associated protein 2 0.1494 0.9812 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.01 0.0137
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0013
Schistosoma mansoni sex comb on midleg homolog 0.0103 0.0585 0.0597
Schistosoma mansoni microtubule-associated protein tau 0.1494 0.9812 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0066 0.0337 0.1267
Trypanosoma brucei unspecified product 0.0073 0.0382 0.1436
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0247
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0117 0.0373
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0106
Schistosoma mansoni DNA polymerase eta 0.0136 0.0801 0.0816
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0238 0.0895
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.01 0.0247
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.009 0.0273
Brugia malayi hypothetical protein 0.0027 0.0082 0.0112
Toxoplasma gondii histone lysine methyltransferase SET1 0.0181 0.1104 0.4111
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0018 0.0022 0.0022
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0179 0.0673
Entamoeba histolytica serine/threonine protein kinase, putative 0.0113 0.0647 0.0822
Brugia malayi Smad1 0.0027 0.0082 0.0112
Schistosoma mansoni lamin 0.0032 0.0112 0.0114
Trypanosoma brucei telomerase reverse transcriptase 0.0416 0.2659 1
Schistosoma mansoni smad1 5 8 and 0.0027 0.0082 0.0083
Loa Loa (eye worm) hypothetical protein 0.0045 0.0195 0.0484
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0238 0.024
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.1882 0.7078
Onchocerca volvulus 0.003 0.01 0.0014
Echinococcus granulosus peregrin 0.0046 0.0207 0.0209
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0228 0.0233
Schistosoma mansoni chromobox protein 0.0069 0.0355 0.0362
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0056 0.0273 0.0376
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0018 0.0018 0.0069
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0171 0.0797
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0089 0.0269
Trypanosoma brucei DNA polymerase eta, putative 0.0136 0.0801 0.3011
Brugia malayi Bromodomain containing protein 0.0083 0.045 0.062
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0056 0.0273 0.0964
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0109 0.0411
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0238 0.1228
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0171 0.0578
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0171 0.1529
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0034 0.0129 0.0131
Echinococcus granulosus histone acetyltransferase MYST2 0.0118 0.068 0.0691
Schistosoma mansoni smad 0.0027 0.0082 0.0083
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0063 0.0321 0.0327
Loa Loa (eye worm) hypothetical protein 0.0621 0.4023 1
Echinococcus multilocularis BRK domain 0.0025 0.0068 0.0067
Brugia malayi calpain 5 0.0019 0.0025 0.0034
Echinococcus multilocularis BRK domain containing protein 0.0025 0.0068 0.0067
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0815 0.0831
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0213 0.1315 0.124
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0025 0.0066 0.0065
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0074 0.039 0.1467
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0106
Echinococcus multilocularis tar DNA binding protein 0.0138 0.0815 0.0829
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.01 0.0102
Echinococcus granulosus mixed lineage leukemia protein mll 0.0025 0.0066 0.0065
Trypanosoma brucei hypothetical protein 0.0113 0.0647 0.2434
Loa Loa (eye worm) inositol-1 0.0036 0.0141 0.0349
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0651 0.2448
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0112 0.0522
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.01 0.0137
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0116 0.0925
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0025 0.0095
Echinococcus granulosus GPCR family 2 0.0069 0.0357 0.0362
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0238 0.1228
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0096
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.0832 0.479
Loa Loa (eye worm) glutaminase 2 0.027 0.1694 0.4209
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0179 0.0673
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0089 0.0336
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0042 0.018 0.0182
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0113 0.0647 0.2434
Entamoeba histolytica hypothetical protein 0.0333 0.2108 0.2735
Trypanosoma cruzi DNA polymerase kappa, putative 0.0137 0.0809 0.3044
Brugia malayi Importin beta-1 subunit 0.0029 0.0089 0.0123
Echinococcus granulosus calpain A 0.0067 0.0342 0.0346
Schistosoma mansoni hypothetical protein 0.0069 0.0357 0.0364
Echinococcus granulosus calpain A 0.0019 0.0025 0.0023
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0109 0.0109
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0113 0.0647 0.0657
Trichomonas vaginalis STE family protein kinase 0.0074 0.039 0.2077
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0141 0.0465
Loa Loa (eye worm) helicase DNA-binding protein 0.0025 0.0068 0.0166
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0273 0.1422
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.01 0.0102
Schistosoma mansoni hypothetical protein 0.1299 0.8521 0.8684
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0066 0.0337 0.1267
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.01 0.0137
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0025 0.0066 0.0065
Onchocerca volvulus 0.0032 0.0112 0.0026
Onchocerca volvulus 0.0045 0.0195 0.011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0863 0.0879
Schistosoma mansoni chromobox protein 0.0069 0.0355 0.0362
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0109 0.0111
Schistosoma mansoni lamin 0.0032 0.0112 0.0114
Loa Loa (eye worm) Smad1 0.0027 0.0082 0.0202
Brugia malayi Flap endonuclease-1 0.0088 0.0482 0.0664
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0018 0.0022 0.002
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0238 0.1228
Schistosoma mansoni ap endonuclease 0.0041 0.0171 0.0174
Brugia malayi latrophilin 2 splice variant baaae 0.0149 0.0887 0.1224
Echinococcus granulosus exonuclease 1 0.0018 0.0018 0.0016
Loa Loa (eye worm) glutaminase 0.027 0.1694 0.4209
Brugia malayi Temporarily assigned gene name protein 44 0.0027 0.0082 0.0112
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0086 0.0598
Plasmodium vivax telomerase reverse transcriptase, putative 0.0416 0.2659 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0106
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0018 0.0018 0.0019
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.1807 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0096
Echinococcus granulosus chromobox protein 1 0.0069 0.0355 0.0359
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0039 0.0161 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.01 0.0137
Loa Loa (eye worm) hypothetical protein 0.0045 0.0195 0.0484
Entamoeba histolytica calpain large subunit domain III containing protein 0.0019 0.0025 0.0009
Loa Loa (eye worm) hypothetical protein 0.0028 0.0086 0.0212
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.01 0.0376
Brugia malayi MH1 domain containing protein 0.0027 0.0082 0.0112
Trypanosoma brucei polo-like protein kinase 0.0113 0.0647 0.2432
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0299 0.1882 0.7078
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0025 0.0095
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0815 0.0831
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0105 0.0599 0.0608
Brugia malayi Steroid receptor seven-up type 2 0.003 0.01 0.0137
Giardia lamblia DNA damage repair protein 0.0033 0.0117 0.0129
Entamoeba histolytica Flap nuclease, putative 0.0088 0.0482 0.0606
Leishmania major DNA polymerase eta, putative 0.0063 0.0319 0.1199
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0238 0.0287
Echinococcus multilocularis Chromo domain 0.0036 0.0142 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.01 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0155 0.0764
Loa Loa (eye worm) hypothetical protein 0.0056 0.0273 0.0677
Brugia malayi calpain 7 0.0019 0.0025 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0137 0.0809 0.3044
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0106
Trypanosoma brucei calpain, putative 0.0113 0.0647 0.2434
Loa Loa (eye worm) CHromoDomain protein family member 0.0018 0.0022 0.0052
Leishmania major kinesin, putative 0.0019 0.0025 0.0095
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0131 0.0772 0.2905
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0025 0.0023
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0086 0.0284
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0016 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0049 0.0226 0.0561
Brugia malayi Inositol-1 0.0036 0.0141 0.0194
Leishmania major DNA polymerase kappa, putative 0.0113 0.0651 0.2448
Leishmania major telomerase reverse transcriptase, putative 0.0416 0.2659 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0137 0.0809 0.3044
Entamoeba histolytica recQ family helicase, putative 0.0028 0.0083 0.0085
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0238 0.0895
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0006 0.0004
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0416 0.2659 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0006 0.0006
Brugia malayi mbt repeat family protein 0.0103 0.0585 0.0808
Brugia malayi nuclear receptor RXR 0.0016 0.0006 0.0007
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.009 0.009
Loa Loa (eye worm) calpain family protein 1 0.0045 0.0195 0.0484
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.01 0.0102
Brugia malayi hypothetical protein 0.0016 0.0006 0.0007
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0944 1
Echinococcus granulosus flap endonuclease 1 0.0088 0.0482 0.0489
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0096
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0174 0.0872
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0041 0.01
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0109 0.0411
Schistosoma mansoni cpg binding protein 0.0124 0.0725 0.0739
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0171 0.0578
Echinococcus granulosus cpg binding protein 0.0131 0.0772 0.0785
Trichomonas vaginalis helicase, putative 0.0021 0.0037 0.0106
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0069 0.0357 0.0362
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0025 0.0068 0.0067
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0141 0.0617
Schistosoma mansoni hypothetical protein 0.0079 0.0421 0.0429
Loa Loa (eye worm) MH2 domain-containing protein 0.0402 0.2565 0.6376
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0109 0.0411
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0647 0.3513
Loa Loa (eye worm) hypothetical protein 0.0038 0.0151 0.0373
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.1807 0.234
Mycobacterium ulcerans hypothetical protein 0.0157 0.0944 0.5469
Onchocerca volvulus Alhambra homolog 0.0029 0.009 0.0004
Mycobacterium ulcerans hypothetical protein 0.0033 0.0117 0.0471
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.01 0.0102
Loa Loa (eye worm) hypothetical protein 0.0069 0.0357 0.0886
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.035 0.0354
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0025 0.0026
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0179 0.0673
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0088 0.0482 0.1811
Echinococcus multilocularis dna polymerase kappa 0.0137 0.0809 0.0823
Echinococcus granulosus dnaJ subfamily B 0.1299 0.8521 0.8684
Loa Loa (eye worm) steroid hormone receptor 0.003 0.01 0.0247
Echinococcus multilocularis musashi 0.0032 0.0112 0.0111
Schistosoma mansoni hypothetical protein 0.0069 0.0357 0.0364
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0086 0.0284
Schistosoma mansoni zinc finger protein 0.0028 0.0088 0.009
Schistosoma mansoni calpain (C02 family) 0.0019 0.0025 0.0026
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0025 0.0026
Echinococcus granulosus tar DNA binding protein 0.0138 0.0815 0.0829
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0113 0.0651 0.2448
Schistosoma mansoni importin beta-1 0.0029 0.0089 0.0091
Schistosoma mansoni hypothetical protein 0.0338 0.2143 0.2184
Schistosoma mansoni flap endonuclease-1 0.0079 0.0426 0.0434
Loa Loa (eye worm) latrophilin receptor protein 2 0.0069 0.0357 0.0886
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0165 0.0166
Echinococcus multilocularis neuropeptide s receptor 0.0546 0.3525 0.3591
Echinococcus granulosus muscleblind protein 0.0621 0.4023 0.4099
Schistosoma mansoni exonuclease 0.0018 0.0018 0.0019
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0039 0.0078
Entamoeba histolytica deoxycytidyl transferase, putative 0.0105 0.0599 0.0759
Loa Loa (eye worm) TAR-binding protein 0.0138 0.0815 0.2026
Trypanosoma cruzi polo-like protein kinase, putative 0.0113 0.0647 0.2432
Brugia malayi PHD-finger family protein 0.0029 0.009 0.0124
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0174 0.0089
Brugia malayi hypothetical protein 0.0523 0.3372 0.4657
Schistosoma mansoni protein kinase 0.0074 0.039 0.0397
Loa Loa (eye worm) transcription factor SMAD2 0.0402 0.2565 0.6376
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0191 0.0195
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0171 0.0643
Brugia malayi Telomerase reverse transcriptase 0.1107 0.7241 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0112 0.0522
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0434 0.1633
Brugia malayi BRM protein 0.0148 0.0883 0.1218
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1807 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0118 0.068 0.0691
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0171 0.0235
Echinococcus granulosus snurportin 1 0.0304 0.192 0.1955
Loa Loa (eye worm) hypothetical protein 0.0197 0.1205 0.2994
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0863 0.0877
Trypanosoma cruzi polo-like protein kinase, putative 0.0113 0.0647 0.2432
Plasmodium falciparum DNA repair protein REV1, putative 0.0033 0.0117 0.0374
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0018 0.0018 0.0016
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0131 0.0772 0.2905
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0025 0.0026
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0117 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0106
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0238 0.0895
Trypanosoma brucei DNA polymerase kappa, putative 0.0137 0.0809 0.3044
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.1807 0.234
Echinococcus multilocularis muscleblind protein 0.0621 0.4023 0.4099
Trypanosoma cruzi DNA damage repair protein, putative 0.0033 0.0117 0.044
Echinococcus multilocularis BRK domain containing protein 0.0025 0.0068 0.0067
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0009 0.0006
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0113 0.0647 0.2434
Echinococcus multilocularis calpain A 0.0067 0.0342 0.0346
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.01 0.0102
Mycobacterium ulcerans glutaminase 0.027 0.1694 1
Trichomonas vaginalis DNA helicase recq, putative 0.0103 0.0582 0.3152
Loa Loa (eye worm) hypothetical protein 0.0103 0.0585 0.1454
Trichomonas vaginalis lymphoid specific helicase, putative 0.0029 0.0092 0.041
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0355 0.1881
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.0023 0.0051 0.0123
Trypanosoma cruzi DNA polymerase kappa, putative 0.0137 0.0809 0.3044
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0116 0.0401
Echinococcus granulosus smad 0.0027 0.0082 0.0081
Leishmania major hypothetical protein, conserved 0.0018 0.0018 0.0069
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0086 0.0284
Echinococcus multilocularis disco interacting protein 2 0.0039 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0049 0.0228 0.0566
Mycobacterium ulcerans hypothetical protein 0.0028 0.0086 0.0284
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0218 0.1344 0.334
Echinococcus multilocularis calpain 0.0019 0.0025 0.0023
Brugia malayi nuclear hormone receptor 0.003 0.01 0.0137
Echinococcus multilocularis BRK domain containing protein 0.0025 0.0068 0.0067
Echinococcus multilocularis BRK domain containing protein 0.0025 0.0068 0.0067
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.192 0.4771
Onchocerca volvulus 0.0032 0.0112 0.0026
Leishmania major modification methylase-like protein 0.002 0.003 0.0112
Schistosoma mansoni hypothetical protein 0.0149 0.0887 0.0904
Loa Loa (eye worm) hypothetical protein 0.0621 0.4023 1
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.01 0.0376
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.128 0.3181
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0105 0.0599 0.1487
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0089 0.0089
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0863 0.0877
Brugia malayi calpain family protein 1 0.0063 0.0321 0.0442
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0031 0.0108 0.0266
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0105 0.0599 0.0608
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0067 0.0342 0.0346
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.01 0.01
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1807 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0838 0.3152
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0171 0.0424
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0174 0.0872
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0141 0.0531
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0089 0.0336
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0069 0.0357 0.0362
Trypanosoma brucei DNA polymerase kappa, putative 0.0137 0.0809 0.3044
Echinococcus granulosus Smad4 0.0027 0.0082 0.0081
Trichomonas vaginalis DNA helicase recq1, putative 0.0103 0.0582 0.3152
Schistosoma mansoni SET domain protein 0.0042 0.018 0.0184
Schistosoma mansoni SET domain protein 0.0023 0.0052 0.0053
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0647 0.3513
Echinococcus granulosus neuropeptide receptor A26 0.0546 0.3525 0.3591
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0113 0.0647 0.2434
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0037 0.0106
Trichomonas vaginalis set domain proteins, putative 0.0236 0.1468 0.8102
Loa Loa (eye worm) hypothetical protein 0.0213 0.1315 0.3268
Trypanosoma brucei unspecified product 0.0129 0.0757 0.2847
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0109 0.0109
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.01 0.0102
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0109 0.0345
Echinococcus multilocularis smad 0.0027 0.0082 0.0081
Trichomonas vaginalis DNA polymerase eta, putative 0.0137 0.0809 0.4422
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.0863 0.2143
Echinococcus multilocularis GPCR, family 2 0.0069 0.0357 0.0362
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0018 0.0018 0.0016
Trichomonas vaginalis STE family protein kinase 0.0074 0.039 0.2077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1807 1
Loa Loa (eye worm) XPG I-region family protein 0.0018 0.0018 0.0044
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0018 0.0018 0.0044
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0112 0.0522
Brugia malayi MAP kinase sur-1 0.0051 0.0238 0.0328
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0523 0.0531
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0112 0.0153
Schistosoma mansoni hypothetical protein 0.0636 0.412 0.4199
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0117 0.044
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0202
Echinococcus multilocularis bloom syndrome protein 0.0103 0.0582 0.0591
Loa Loa (eye worm) hypothetical protein 0.0523 0.3372 0.8382
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0112 0.0522
Schistosoma mansoni coup transcription factor 0.003 0.01 0.0102
Echinococcus multilocularis flap endonuclease 1 0.0088 0.0482 0.0489
Echinococcus multilocularis dna polymerase eta 0.0136 0.0801 0.0814
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1807 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0054 0.0197
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.01 0.0137
Echinococcus granulosus hypothetical protein 0.0027 0.0082 0.0081
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0109 0.0853
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0112 0.0522
Schistosoma mansoni thyroid hormone receptor 0.003 0.01 0.0102
Echinococcus multilocularis histone acetyltransferase MYST2 0.0118 0.068 0.0691
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0006 0.0007
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.002 0.003 0.0112
Trypanosoma brucei DNA damage repair protein, putative 0.0033 0.0117 0.044
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0086 0.0089
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.1807 0.234
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0247
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0004
Trichomonas vaginalis glutaminase, putative 0.027 0.1694 0.9367
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0141 0.0161
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0138 0.0815 0.2026
Schistosoma mansoni hypothetical protein 0.0338 0.2143 0.2184
Schistosoma mansoni Smad4 0.0027 0.0082 0.0083
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0113 0.0647 0.2434
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0228 0.023
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0109 0.0411
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0074 0.039 0.0538
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0113 0.0647 0.1606
Plasmodium vivax DNA repair protein REV1, putative 0.0033 0.0117 0.0374
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0247
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0155 0.007
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0056 0.0273 0.0677
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.002 0.003 0.0043
Onchocerca volvulus 0.0124 0.0725 0.0645
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0086 0.0089
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0065 0.0328 0.1173
Brugia malayi PHD-finger family protein 0.0034 0.0123 0.0169
Brugia malayi Calcitonin receptor-like protein seb-1 0.0218 0.1344 0.1855
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0088 0.0087
Brugia malayi serine/threonine-protein kinase plk-2 0.0113 0.0647 0.0892
Loa Loa (eye worm) BRM protein 0.0078 0.0416 0.1032
Schistosoma mansoni hypothetical protein 0.0027 0.0082 0.0083
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0086 0.0324
Echinococcus granulosus FTZ F1 alpha 0.003 0.01 0.01
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.1882 0.7078
Echinococcus multilocularis lamin 0.0032 0.0112 0.0111
Echinococcus granulosus geminin 0.0338 0.2143 0.2183
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0113 0.0647 0.2432
Schistosoma mansoni helicase 0.0148 0.0883 0.09
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0082 0.0083
Giardia lamblia Telomerase catalytic subunit 0.0416 0.2659 0.3455
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0018 0.0022 0.002
Giardia lamblia DINP protein human, muc B family 0.0113 0.0651 0.0828
Echinococcus multilocularis chromobox protein 1 0.0069 0.0355 0.0359
Brugia malayi chromobox protein homolog 3 0.0038 0.0155 0.0213
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0088 0.0482 0.1811
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0109 0.0411
Plasmodium falciparum importin beta, putative 0.0029 0.0089 0.0269
Echinococcus granulosus SAM and MBT domain containing protein 0.0103 0.0585 0.0594
Brugia malayi N-terminal motif family protein 0.0213 0.1315 0.1816
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0056 0.0273 0.0964
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0863 0.0877
Brugia malayi jmjC domain containing protein 0.0094 0.0523 0.0722
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0054 0.0197
Mycobacterium tuberculosis Conserved hypothetical protein 0.0105 0.0599 0.6215
Schistosoma mansoni DNA helicase recq5 0.0056 0.0273 0.0278
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0177 0.0181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.01 0.0247
Brugia malayi RNA recognition motif domain containing protein 0.0138 0.0815 0.1125
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0025 0.0095
Trypanosoma brucei unspecified product 0.0073 0.0382 0.1436
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1807 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0171 0.0172
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0112 0.0522
Loa Loa (eye worm) hypothetical protein 0.0032 0.0112 0.0276
Brugia malayi Pre-SET motif family protein 0.0208 0.128 0.1767
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0006 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0238 0.0243
Brugia malayi Heterochromatin protein 1 0.0069 0.0355 0.0489
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0113 0.0647 0.2434
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0177 0.0439
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0141 0.0531
Brugia malayi PHD-finger family protein 0.0016 0.0009 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0647 0.3513
Trypanosoma cruzi DNA polymerase eta, putative 0.0136 0.0801 0.3011
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.01 0.0137
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.002 0.003 0.003
Trypanosoma brucei chrX additional, unordered contigs 0.0033 0.0117 0.044
Echinococcus granulosus calpain 5 0.0019 0.0025 0.0023
Echinococcus granulosus jumonji domain containing protein 0.004 0.0165 0.0166
Echinococcus multilocularis dual specificity mitogen activated protein 0.0074 0.039 0.0395
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0177 0.0179
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.01 0.0014
Schistosoma mansoni smad1 5 8 and 0.0027 0.0082 0.0083
Trypanosoma brucei DNA polymerase IV, putative 0.0137 0.0809 0.3044
Brugia malayi ImpB/MucB/SamB family protein 0.0136 0.0801 0.1105
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0039 0.0083
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0238 0.0895
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0141 0.0687
Trypanosoma brucei DNA polymerase IV, putative 0.0129 0.0757 0.2847
Schistosoma mansoni blooms syndrome DNA helicase 0.0074 0.0392 0.04
Echinococcus granulosus flap endonuclease GEN 1 0.0018 0.0018 0.0016
Giardia lamblia PHD finger protein 15 0.0029 0.009 0.0094
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.0647 0.0659
Trypanosoma brucei antigen, putative 0.0019 0.0025 0.0095
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0035 0.0085
Schistosoma mansoni hypothetical protein 0.0036 0.0142 0.0145
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0247
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0196 0.12 0.1223
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0218 0.1344 0.1855
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.01 0.0247
Toxoplasma gondii DNA methyltransferase 2, putative 0.002 0.003 0.0043
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0013 0.0032
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.01 0.0102
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0238 0.0895
Echinococcus multilocularis flap endonuclease GEN 1 0.0018 0.0018 0.0016
Brugia malayi steroid hormone receptor 0.003 0.01 0.0137

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) 7.0795 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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