TDR Targets

Basic information

Technical information

TDR Targets ID: 1383742
Name: 2-[(3,4-dimethylphenyl)-methylsulfonylamino]- N-methyl-N-(phenylmethyl)acetamide
MW: 360.47 | Formula: C19H24N2O3S
H donors: 0 H acceptors: 3 LogP: 2.82 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N(Cc1ccccc1)C)CN(S(=O)(=O)C)c1ccc(c(c1)C)C
InChi: 1S/C19H24N2O3S/c1-15-10-11-18(12-16(15)2)21(25(4,23)24)14-19(22)20(3)13-17-8-6-5-7-9-17/h5-12H,13-14H2,1-4H3
InChiKey: LDMXKXRHTXWRLB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[(3,4-dimethylphenyl)-methylsulfonyl-amino]-N-methyl-N-(phenylmethyl)acetamide
N-(benzyl)-2-[(3,4-dimethylphenyl)-mesyl-amino]-N-methyl-acetamide
2-[(3,4-dimethylphenyl)-methylsulfonyl-amino]-N-methyl-N-(phenylmethyl)ethanamide
ZINC00816836
Oprea1_214665
BAS 02177025
N-Benzyl-2-[(3,4-dimethyl-phenyl)-methanesulfonyl-amino]-N-methyl-acetamide
Oprea1_774076

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	aurora kinase A	0.0084	0.0086	0.0097
Brugia malayi	IPT/TIG domain containing protein	0.0181	0.0271	0.0266
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0098	0.0113	0.0105
Echinococcus granulosus	semaphorin 5B	0.0412	0.0715	0.0849
Echinococcus multilocularis	beta adrenergic receptor kinase	0.4025	0.7648	0.914
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.006	0.004	0.0041
Echinococcus multilocularis	dynamin 1	0.0078	0.0075	0.0083
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0181	0.0271	0.174
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.004	0.0254
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.004	0.0034
Echinococcus granulosus	tyrosine protein kinase shark	0.006	0.004	0.0041
Loa Loa (eye worm)	RGS-3 protein	0.0851	0.1558	0.1554
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.006	0.004	0.0034
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0075	0.0478
Trichomonas vaginalis	conserved hypothetical protein	0.0851	0.1558	1
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Brugia malayi	Guanylyl cyclase protein 23	0.006	0.004	0.0034
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0078	0.0075	0.6226
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0099	0.0115	1
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0075	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0075	0.0069
Echinococcus multilocularis	oxysterol binding protein 9	0.0078	0.0075	0.0083
Trichomonas vaginalis	conserved hypothetical protein	0.0181	0.0271	0.174
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0078	0.0075	0.023
Loa Loa (eye worm)	rho-GTPase-activating	0.0078	0.0075	0.0069
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0078	0.0075	0.023
Echinococcus multilocularis	tyrosine protein kinase shark	0.006	0.004	0.0041
Loa Loa (eye worm)	hypothetical protein	0.006	0.004	0.0034
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0078	0.0075	0.0083
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0851	0.1558	0.1551
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.004	0.0034
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.006	0.004	0.0041
Brugia malayi	hypothetical protein	0.006	0.004	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0075	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0123	0.0118
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0099	0.0115	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0008	0.0052
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0078	0.0075	0.0067
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0099	0.0115	1
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0099	0.0115	1
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0078	0.0075	0.0373
Trichomonas vaginalis	alpha chimerin, putative	0.0078	0.0075	0.0478
Brugia malayi	hypothetical protein	0.0078	0.0075	0.0069
Echinococcus granulosus	calcium dependent secretion activator 1	0.0078	0.0075	0.0083
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Brugia malayi	serine/threonine protein kinase 6	0.0084	0.0086	0.0081
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0099	0.0115	0.0495
Schistosoma mansoni	growth factor receptor-bound protein	0.0078	0.0075	0.0067
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0031	0.003
Brugia malayi	Uncoordinated protein 104	0.0078	0.0075	0.0069
Schistosoma mansoni	serine/threonine RGC	0.006	0.004	0.0032
Brugia malayi	Pleckstrin Homology Domain	0.0078	0.0075	0.0069
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0078	0.0075	0.0478
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Trichomonas vaginalis	conserved hypothetical protein	0.0181	0.0271	0.174
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.006	0.004	0.0032
Schistosoma mansoni	protein kinase	0.006	0.004	0.0032
Brugia malayi	PH domain containing protein	0.0078	0.0075	0.0069
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Loa Loa (eye worm)	hypothetical protein	0.0181	0.0271	0.0266
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Trichomonas vaginalis	esterase, putative	0.0043	0.0008	0.0052
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.004	0.0254
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.004	0.0254
Echinococcus multilocularis	tyrosine kinase	0.006	0.004	0.0041
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0031	0.003
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Trichomonas vaginalis	conserved hypothetical protein	0.0181	0.0271	0.174
Brugia malayi	ephrin receptor 1 precursor	0.006	0.004	0.0034
Schistosoma mansoni	protein kinase	0.006	0.004	0.0032
Onchocerca volvulus		0.006	0.004	0.0177
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Schistosoma mansoni	protein kinase	0.0081	0.008	0.0072
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0078	0.0075	0.0083
Schistosoma mansoni	regulator of G protein signaling	0.0851	0.1558	0.1551
Trypanosoma brucei	Pseudokinase, putative	0.006	0.004	0.2955
Echinococcus multilocularis	tyrosine protein kinase HCK	0.006	0.004	0.0041
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0084	0.0086	0.7319
Trypanosoma brucei	aurora B kinase	0.0084	0.0086	0.7319
Echinococcus granulosus	tyrosine protein kinase	0.006	0.004	0.0041
Schistosoma mansoni	hypothetical protein	0.0078	0.0075	0.0067
Schistosoma mansoni	tyrosine protein kinase	0.006	0.004	0.0032
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0084	0.0086	0.0307
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.006	0.004	0.0041
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0075	0.0478
Brugia malayi	serine/threonine-protein kinase 6	0.0084	0.0086	0.0081
Echinococcus granulosus	tyrosine protein kinase Srms	0.006	0.004	0.0041
Echinococcus multilocularis	kinase suppressor of Ras 1	0.006	0.004	0.0041
Brugia malayi	Protein kinase domain containing protein	0.0099	0.0115	0.011
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0078	0.0075	0.0373
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0008	0.5
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0113	0.0108
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0078	0.0075	0.6226
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0078	0.0075	0.023
Echinococcus multilocularis	tyrosine protein kinase csk	0.006	0.004	0.0041
Echinococcus granulosus	dynamin 1	0.0078	0.0075	0.0083
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0078	0.0075	0.0083
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Brugia malayi	PXA domain containing protein	0.0851	0.1558	0.1554
Brugia malayi	PH domain containing protein	0.0078	0.0075	0.0069
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.004	0.0034
Echinococcus granulosus	tyrosine protein kinase HCK	0.006	0.004	0.0041
Echinococcus granulosus	protein tyrosine kinase	0.006	0.004	0.0041
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Echinococcus granulosus	receptor type guanylyl cyclase	0.006	0.004	0.0041
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0078	0.0075	0.0083
Schistosoma mansoni	zinc finger protein	0.0078	0.0075	0.0067
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0078	0.0075	0.023
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.006	0.004	0.0041
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0075	0.0478
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Loa Loa (eye worm)	TK protein kinase	0.006	0.004	0.0034
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.006	0.004	0.2955
Schistosoma mansoni	goodpasture antigen-binding protein	0.0078	0.0075	0.0067
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Onchocerca volvulus		0.006	0.004	0.0177
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Entamoeba histolytica	hypothetical protein	0.0078	0.0075	0.023
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.006	0.004	0.0041
Echinococcus multilocularis	tyrosine kinase	0.006	0.004	0.0041
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.006	0.004	0.0041
Loa Loa (eye worm)	plexin A	0.1153	0.2136	0.2132
Echinococcus granulosus	GRB2 associated binding protein 3	0.0078	0.0075	0.0083
Echinococcus multilocularis	natriuretic peptide receptor 1	0.006	0.004	0.0041
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Loa Loa (eye worm)	hypothetical protein	0.006	0.004	0.0034
Onchocerca volvulus		0.006	0.004	0.0177
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.004	0.0034
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Entamoeba histolytica	protein kinase, putative	0.0099	0.0115	0.0495
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0099	0.0115	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.006	0.004	0.0041
Onchocerca volvulus		0.006	0.004	0.0177
Entamoeba histolytica	protein kinase, putative	0.0084	0.0086	0.0307
Trichomonas vaginalis	centaurin gamma, putative	0.0078	0.0075	0.0478
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Echinococcus granulosus	pdz domain containing protein	0.0078	0.0075	0.0083
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0078	0.0075	0.0083
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.006	0.004	0.0032
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Entamoeba histolytica	hypothetical protein	0.0099	0.0115	0.0495
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.004	0.0034
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0078	0.0075	0.023
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.006	0.004	0.0041
Loa Loa (eye worm)	TK/ACK protein kinase	0.006	0.004	0.0034
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Trichomonas vaginalis	centaurin alpha, putative	0.0078	0.0075	0.0478
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.006	0.004	0.0041
Entamoeba histolytica	hypothetical protein	0.0078	0.0075	0.023
Loa Loa (eye worm)	TK/CSK protein kinase	0.006	0.004	0.0034
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.006	0.004	0.0032
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0075	0.0069
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0078	0.0075	0.0083
Echinococcus granulosus	Immunoglobulin	0.0098	0.0113	0.0129
Loa Loa (eye worm)	TK protein kinase	0.006	0.004	0.0034
Trypanosoma cruzi	protein kinase, putative	0.006	0.004	0.2955
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0078	0.0075	0.0478
Loa Loa (eye worm)	hypothetical protein	0.006	0.004	0.0034
Onchocerca volvulus		0.0078	0.0075	0.0373
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0031	0.003
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0081	0.008	0.0089
Onchocerca volvulus		0.006	0.004	0.0177
Entamoeba histolytica	hypothetical protein	0.0078	0.0075	0.023
Onchocerca volvulus		0.0078	0.0075	0.0373
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Echinococcus multilocularis	epidermal growth factor receptor	0.006	0.004	0.0041
Schistosoma mansoni	semaphorin 5-related	0.0412	0.0715	0.0708
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0078	0.0075	0.023
Loa Loa (eye worm)	TK protein kinase	0.006	0.004	0.0034
Echinococcus granulosus	oxysterol binding protein 9	0.0078	0.0075	0.0083
Brugia malayi	Plekhf2 protein	0.0078	0.0075	0.0069
Echinococcus multilocularis	myotubularin protein 13	0.0078	0.0075	0.0083
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.004	0.0254
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0078	0.0075	0.0083
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Echinococcus granulosus	Pleckstrin y	0.0078	0.0075	0.0083
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0078	0.0075	0.4643
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0078	0.0075	0.0083
Schistosoma mansoni	z-protein (S1r protein)	0.0851	0.1558	0.1551
Plasmodium falciparum	PH domain-containing protein, putative	0.0078	0.0075	0.4643
Trichomonas vaginalis	protein transport protein sec7, putative	0.0078	0.0075	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0075	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0412	0.0715	0.071
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0084	0.0086	0.0097
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.006	0.004	0.0034
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0078	0.0075	0.4643
Brugia malayi	protein-tyrosine kinase	0.006	0.004	0.0034
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Schistosoma mansoni	vesicular amine transporter	0.0101	0.0119	0.0111
Echinococcus multilocularis	epidermal growth factor receptor	0.006	0.004	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0181	0.0271	0.0266
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.006	0.004	0.0034
Trichomonas vaginalis	conserved hypothetical protein	0.0181	0.0271	0.174
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0078	0.0075	0.0083
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.006	0.004	0.0032
Brugia malayi	PH domain containing protein	0.0078	0.0075	0.0069
Echinococcus granulosus	oxysterol binding protein 1	0.0078	0.0075	0.0083
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Schistosoma mansoni	protein kinase	0.0081	0.008	0.0072
Echinococcus multilocularis	tyrosine protein kinase pr2	0.006	0.004	0.0041
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.006	0.004	0.0041
Echinococcus multilocularis	heat shock protein 70	0.006	0.004	0.0041
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Trypanosoma brucei	Flagellum attachment zone protein 20	0.006	0.004	0.2955
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0008	0.5
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0078	0.0075	0.023
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Brugia malayi	SH2 domain containing protein	0.006	0.004	0.0034
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.006	0.004	0.0034
Leishmania major	protein kinase, putative	0.006	0.004	0.2955
Entamoeba histolytica	PH domain containing protein	0.0078	0.0075	0.023
Brugia malayi	Oxysterol binding protein	0.0078	0.0075	0.0069
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.006	0.004	0.0041
Trichomonas vaginalis	AGC family protein kinase	0.0084	0.0086	0.0553
Echinococcus granulosus	twitchin	0.0119	0.0154	0.0178
Entamoeba histolytica	protein kinase, putative	0.0099	0.0115	0.0495
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0099	0.0115	0.0737
Loa Loa (eye worm)	hypothetical protein	0.006	0.004	0.0034
Loa Loa (eye worm)	SRC-1	0.006	0.004	0.0034
Onchocerca volvulus		0.006	0.004	0.0177
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.44	0.8366	1
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.004	0.0254
Echinococcus multilocularis	oxysterol binding protein 1	0.0078	0.0075	0.0083
Echinococcus granulosus	epidermal growth factor receptor	0.006	0.004	0.0041
Brugia malayi	Tyrosine-protein kinase PR2	0.006	0.004	0.0034
Plasmodium vivax	tyrosine kinase-like protein, putative	0.006	0.004	0.2955
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.004	0.0032
Schistosoma mansoni	oxysterol-binding protein 1	0.0078	0.0075	0.0067
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0075	0.0478
Onchocerca volvulus		0.006	0.004	0.0177
Schistosoma mansoni	axis inhibition protein axin	0.0851	0.1558	0.1551
Echinococcus multilocularis	axis inhibition protein axin	0.0851	0.1558	0.1857
Brugia malayi	Sema domain containing protein	0.0412	0.0715	0.071
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.006	0.004	0.0041
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.006	0.004	0.0034
Brugia malayi	Tyrosine-protein kinase abl-1	0.006	0.004	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0008	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0075	0.0069
Loa Loa (eye worm)	TK/ALK protein kinase	0.0326	0.055	0.0545
Entamoeba histolytica	hypothetical protein	0.0181	0.0271	0.1524
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.004	0.0034
Leishmania major	hypothetical protein, conserved	0.0078	0.0075	0.6226
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.006	0.004	0.0041
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0084	0.0086	0.0307
Echinococcus granulosus	activin receptor type	0.0081	0.008	0.0089
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0104	0.0123	0.0118
Echinococcus multilocularis	protein KINase family member (kin 25)	0.006	0.004	0.0041
Echinococcus granulosus	cytohesin 1	0.0078	0.0075	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0851	0.1558	0.1554
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0084	0.0086	0.6194
Schistosoma mansoni	hypothetical protein	0.0078	0.0075	0.0067
Loa Loa (eye worm)	hypothetical protein	0.006	0.004	0.0034
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Echinococcus multilocularis	rac serine:threonine kinase	0.0099	0.0115	0.0131
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0078	0.0075	0.023
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Trypanosoma cruzi	PH domain containing protein, putative	0.0078	0.0075	0.6226
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.006	0.004	0.0034
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Entamoeba histolytica	protein kinase, putative	0.0084	0.0086	0.0307
Entamoeba histolytica	p21-activated kinase	0.0099	0.0115	0.0495
Brugia malayi	Immunoglobulin I-set domain containing protein	0.006	0.004	0.0034
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0099	0.0115	0.0495
Echinococcus granulosus	tyrosine protein kinase pr2	0.006	0.004	0.0041
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0081	0.008	0.6729
Echinococcus granulosus	tyrosine protein kinase csk	0.006	0.004	0.0041
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0078	0.0075	0.0083
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.006	0.004	0.0041
Loa Loa (eye worm)	TK protein kinase	0.006	0.004	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0972	0.179	0.1785
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0078	0.0075	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0234	0.0374	0.0368
Trypanosoma cruzi	NIMA-related kinase, putative	0.0099	0.0115	1
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0008	0.0003
Trichomonas vaginalis	STE family protein kinase	0.006	0.004	0.0254
Trichomonas vaginalis	AGC family protein kinase	0.0084	0.0086	0.0553
Entamoeba histolytica	protein kinase domain containing protein	0.024	0.0386	0.2281
Trypanosoma cruzi	hypothetical protein	0.0078	0.0075	0.6226
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0081	0.008	0.6729
Brugia malayi	MAX-1A	0.0078	0.0075	0.0069
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0099	0.0115	0.0495
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0078	0.0075	0.023
Schistosoma mansoni	regulator of G protein signaling	0.0851	0.1558	0.1551
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0078	0.0075	0.0083
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0098	0.0113	0.0129
Schistosoma mansoni	serine/threonine protein kinase	0.0084	0.0086	0.0078
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0078	0.0075	0.0478
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.004	0.0034
Toxoplasma gondii	protein kinase domain-containing protein	0.006	0.004	0.2955
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0113	0.0108
Schistosoma mansoni	protein kinase	0.006	0.004	0.0032
Brugia malayi	Cadps2 protein	0.0078	0.0075	0.0069
Echinococcus granulosus	axis inhibition protein axin	0.0851	0.1558	0.1857
Brugia malayi	Variant SH3 domain containing protein	0.0078	0.0075	0.0069
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0078	0.0075	0.023
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Loa Loa (eye worm)	TK/INSR protein kinase	0.006	0.004	0.0034
Schistosoma mansoni	myotubularin-related protein	0.0078	0.0075	0.0067
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.006	0.004	0.0032
Trichomonas vaginalis	conserved hypothetical protein	0.0851	0.1558	1
Brugia malayi	hypothetical protein	0.0104	0.0123	0.0118
Loa Loa (eye worm)	RGC/RGC protein kinase	0.006	0.004	0.0034
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0078	0.0075	0.0069
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0075	0.0478
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.004	0.0034
Loa Loa (eye worm)	TK/ABL protein kinase	0.006	0.004	0.0034
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.006	0.004	0.0041
Echinococcus multilocularis	FL cytokine receptor	0.006	0.004	0.0041
Loa Loa (eye worm)	oxysterol binding protein	0.0078	0.0075	0.0069
Echinococcus multilocularis	protein kinase	0.006	0.004	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0851	0.1558	0.1554
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0075	0.0069
Entamoeba histolytica	protein kinase domain containing protein	0.0081	0.008	0.0265
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.44	0.8366	1
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0075	0.0478
Loa Loa (eye worm)	TK/RYK protein kinase	0.006	0.004	0.0034
Echinococcus granulosus	Pleckstrin y	0.0078	0.0075	0.0083
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Echinococcus granulosus	transcription factor collier	0.0181	0.0271	0.0318
Trypanosoma brucei	protein kinase, putative	0.0081	0.008	0.6729
Echinococcus multilocularis	tyrosine protein kinase csk	0.006	0.004	0.0041
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.004	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0075	0.0069
Schistosoma mansoni	regulator of G protein signaling	0.0851	0.1558	0.1551
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0158	0.0228	0.0223
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Entamoeba histolytica	cell surface protease gp63, putative	0.0181	0.0271	0.1524
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.44	0.8366	0.8366
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0078	0.0075	0.6226
Plasmodium vivax	hypothetical protein, conserved	0.0078	0.0075	0.6226
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Schistosoma mansoni	serine/threonine protein kinase	0.4025	0.7648	0.7646
Onchocerca volvulus		0.006	0.004	0.0177
Echinococcus granulosus	tyrosine protein kinase Src42A	0.006	0.004	0.0041
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.006	0.004	0.0041
Echinococcus granulosus	c src tyrosine kinase	0.006	0.004	0.0041
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0008	0.5
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0075	0.0069
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0075	0.0478
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.006	0.004	0.0041
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.006	0.004	0.0041
Echinococcus granulosus	neuroglian	0.0098	0.0113	0.0129
Entamoeba histolytica	hypothetical protein, conserved	0.0078	0.0075	0.023
Loa Loa (eye worm)	hypothetical protein	0.006	0.004	0.0034
Echinococcus granulosus	serine/threonine protein kinase	0.0099	0.0115	0.0131
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0078	0.0075	0.0478
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0099	0.0115	0.0495
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.004	0.0032
Toxoplasma gondii	protein kinase domain-containing protein	0.0099	0.0115	1
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0099	0.0115	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.004	0.0034
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0099	0.0115	0.0737
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0008	0.0003
Onchocerca volvulus		0.006	0.004	0.0177
Brugia malayi	serine/threonine kinase 12	0.0084	0.0086	0.0081
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.006	0.004	0.0041
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0099	0.0115	1
Loa Loa (eye worm)	hypothetical protein	0.0412	0.0715	0.071
Brugia malayi	PXA domain containing protein	0.0851	0.1558	0.1554
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.3174	0.6014	0.7186
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0078	0.0075	0.0083
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.006	0.004	0.0041
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Echinococcus granulosus	tyrosine kinase	0.006	0.004	0.0041
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0008	0.0003
Echinococcus granulosus	myotubularin protein 13	0.0078	0.0075	0.0083
Brugia malayi	Cytohesin 3	0.0078	0.0075	0.0069
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.0458	1
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0078	0.0075	0.023
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0008	0.0052
Loa Loa (eye worm)	AUR protein kinase	0.0084	0.0086	0.0081
Schistosoma mansoni	ephrin receptor	0.006	0.004	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0008	0.0003
Schistosoma mansoni	hypothetical protein	0.0181	0.0271	0.0263
Echinococcus multilocularis	exocyst complex component 2	0.0181	0.0271	0.0318
Schistosoma mansoni	hypothetical protein	0.0078	0.0075	0.0067
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.006	0.004	0.0041
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0099	0.0115	1
Schistosoma mansoni	voltage-gated potassium channel	0.0046	0.0013	0.0005
Trichomonas vaginalis	AGC family protein kinase	0.0084	0.0086	0.0553
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0008	0.0003
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0078	0.0075	0.023
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Schistosoma mansoni	protein kinase	0.0084	0.0086	0.0078
Echinococcus multilocularis	tyrosine protein kinase	0.006	0.004	0.0041
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.004	0.0034
Brugia malayi	hypothetical protein	0.006	0.004	0.0034
Trypanosoma brucei	PH domain containing protein, putative	0.0078	0.0075	0.6226
Echinococcus multilocularis	regulator of G protein signaling 3	0.0851	0.1558	0.1857
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0081	0.008	0.0089
Trichomonas vaginalis	centaurin/arf, putative	0.0078	0.0075	0.0478
Echinococcus granulosus	activated cdc42 kinase 1	0.006	0.004	0.0041
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0078	0.0075	0.0083
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.006	0.004	0.0177
Brugia malayi	SH2 domain containing protein	0.006	0.004	0.0034
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0181	0.0271	0.174
Onchocerca volvulus		0.0078	0.0075	0.0373
Brugia malayi	hypothetical protein	0.0412	0.0715	0.071
Echinococcus multilocularis	expressed protein	0.0851	0.1558	0.1857
Loa Loa (eye worm)	protein kinase domain-containing protein	0.006	0.004	0.0034
Loa Loa (eye worm)	TK protein kinase	0.006	0.004	0.0034
Echinococcus multilocularis	hypothetical protein	0.0412	0.0715	0.0849
Echinococcus multilocularis	regulator of G protein signaling 7	0.0851	0.1558	0.1857
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0851	0.1558	0.1551
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.006	0.004	0.0041
Brugia malayi	A-kinase anchor protein 10, precursor	0.0851	0.1558	0.1554
Loa Loa (eye worm)	AUR protein kinase	0.0084	0.0086	0.0081
Leishmania major	protein kinase, putative	0.0099	0.0115	1
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Schistosoma mansoni	protein tyrosine kinase	0.006	0.004	0.0032
Toxoplasma gondii	protein kinase	0.006	0.004	0.2955
Brugia malayi	bone morphogenetic protein type 1 receptor	0.006	0.004	0.0034
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.004	0.0032
Echinococcus multilocularis	transfer RNA-Thr	0.006	0.004	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0008	0.0003
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0078	0.0075	0.0083
Brugia malayi	Probable exocyst complex component Sec5	0.0181	0.0271	0.0266
Loa Loa (eye worm)	TK protein kinase	0.006	0.004	0.0034
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.006	0.004	0.0177
Schistosoma mansoni	cell adhesion molecule	0.0104	0.0123	0.0115
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.006	0.004	0.0041
Loa Loa (eye worm)	hypothetical protein	0.006	0.004	0.0034
Onchocerca volvulus		0.0972	0.179	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.006	0.004	0.0034
Echinococcus granulosus	tyrosine protein kinase csk	0.006	0.004	0.0041
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.006	0.004	0.2955
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0099	0.0115	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.006	0.004	0.0041
Trichomonas vaginalis	TK family protein kinase	0.006	0.004	0.0254
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.006	0.004	0.0041
Trichomonas vaginalis	conserved hypothetical protein	0.0851	0.1558	1
Loa Loa (eye worm)	Plekhf2 protein	0.0078	0.0075	0.0069
Trypanosoma cruzi	hypothetical protein	0.0078	0.0075	0.6226
Loa Loa (eye worm)	serine/threonine protein kinase	0.006	0.004	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0113	0.0108
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.004	0.0034
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Schistosoma mansoni	protein kinase	0.006	0.004	0.0032
Loa Loa (eye worm)	hypothetical protein	0.006	0.004	0.0034
Schistosoma mansoni	dynamin	0.0078	0.0075	0.0067
Trichomonas vaginalis	AGC family protein kinase	0.006	0.004	0.0254
Trypanosoma cruzi	NIMA-related kinase, putative	0.0099	0.0115	1
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.5251	1	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0099	0.0115	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.006	0.004	0.0041
Echinococcus granulosus	tyrosine protein kinase Blk	0.006	0.004	0.0041
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.006	0.004	0.0041
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.006	0.004	0.0041
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0081	0.008	0.6729
Schistosoma mansoni	serine/threonine protein kinase	0.5251	1	1
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0078	0.0075	0.0083
Echinococcus granulosus	pleckstrin y domain containing family A	0.0078	0.0075	0.0083
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.006	0.004	0.0254
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0078	0.0075	0.0069
Leishmania major	protein kinase, putative	0.0084	0.0086	0.7319
Echinococcus granulosus	fibroblast growth factor receptor 4	0.006	0.004	0.0041
Entamoeba histolytica	hypothetical protein	0.0181	0.0271	0.1524
Echinococcus multilocularis	cytohesin 1	0.0078	0.0075	0.0083
Echinococcus multilocularis	Pleckstrin y	0.0078	0.0075	0.0083
Echinococcus multilocularis	insulin receptor	0.006	0.004	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0123	0.0118
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0113	0.0108
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.004	0.0032
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0851	0.1558	0.1554
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0075	0.0069
Echinococcus multilocularis	Pleckstrin y	0.0078	0.0075	0.0083
Echinococcus granulosus	Regulator of G protein signaling 20	0.0851	0.1558	0.1857
Loa Loa (eye worm)	TK/EGFR protein kinase	0.006	0.004	0.0034
Loa Loa (eye worm)	uncoordinated protein 104	0.0078	0.0075	0.0069
Echinococcus multilocularis	Oxysterol binding protein 11	0.0078	0.0075	0.0083
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0078	0.0075	0.0083
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0078	0.0075	0.023
Brugia malayi	Dynamin	0.0078	0.0075	0.0069
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Loa Loa (eye worm)	AUR protein kinase	0.0084	0.0086	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0075	0.0069
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.006	0.004	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0123	0.0118
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.006	0.004	0.0034
Echinococcus granulosus	natriuretic peptide receptor 1	0.006	0.004	0.0041
Echinococcus multilocularis	roundabout 2	0.0104	0.0123	0.0141
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.006	0.004	0.0041
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Echinococcus multilocularis	integrin linked protein kinase	0.006	0.004	0.0041
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.006	0.004	0.0041
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0078	0.0075	0.023
Brugia malayi	hypothetical protein	0.0412	0.0715	0.071
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.006	0.004	0.0041
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Toxoplasma gondii	hypothetical protein	0.0078	0.0075	0.6226
Echinococcus multilocularis	tyrosine protein kinase Abl	0.006	0.004	0.0041
Echinococcus granulosus	kinase suppressor of Ras 1	0.006	0.004	0.0041
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Plasmodium falciparum	protein kinase, putative	0.0081	0.008	0.5357
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0181	0.0271	0.174
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0008	0.0003
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0031	0.003
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.004	0.0034
Schistosoma mansoni	hypothetical protein	0.006	0.004	0.0032
Leishmania major	serine/threonine-protein kinase a, putative	0.0099	0.0115	1
Echinococcus granulosus	oxysterol binding protein 3	0.0078	0.0075	0.0083
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0078	0.0075	0.0478
Loa Loa (eye worm)	RGC/RGC protein kinase	0.006	0.004	0.0034
Echinococcus multilocularis	oxysterol binding protein 3	0.0078	0.0075	0.0083
Toxoplasma gondii	hypothetical protein	0.0078	0.0075	0.6226
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0078	0.0075	0.0083
Brugia malayi	beta-lactamase family protein	0.0043	0.0008	0.0003
Leishmania major	folate/biopterin transporter, putative	0.0099	0.0115	1
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0075	0.0478
Echinococcus granulosus	G protein coupled receptor kinase 1	0.3174	0.6014	0.7186
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0008	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0181	0.0271	0.174
Loa Loa (eye worm)	hypothetical protein	0.0851	0.1558	0.1554
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Echinococcus granulosus	tyrosine protein kinase csk	0.006	0.004	0.0041
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Brugia malayi	SRC-1	0.006	0.004	0.0034
Entamoeba histolytica	tyrosin kinase, putative	0.024	0.0386	0.2281
Trichomonas vaginalis	protein transport protein sec7, putative	0.0078	0.0075	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0075	0.0069
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0099	0.0115	1
Echinococcus multilocularis	protein kinase	0.006	0.004	0.0041
Trypanosoma cruzi	PH domain containing protein, putative	0.0078	0.0075	0.6226
Schistosoma mansoni	axis inhibition protein axin	0.0851	0.1558	0.1551
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0078	0.0075	0.0083
Echinococcus multilocularis	transcription factor collier	0.0181	0.0271	0.0318
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0851	0.1558	0.1554
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.006	0.004	0.0041
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0078	0.0075	0.0069
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.006	0.004	0.0034
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0075	0.0069
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0099	0.0115	1
Echinococcus multilocularis	actin binding protein anillin	0.0078	0.0075	0.0083
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0084	0.0086	0.0307
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Echinococcus granulosus	tyrosine protein kinase Src64B	0.006	0.004	0.0041
Trypanosoma cruzi	hypothetical protein	0.0078	0.0075	0.6226
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Loa Loa (eye worm)	hypothetical protein	0.006	0.004	0.0034
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Plasmodium falciparum	oxysterol-binding protein, putative	0.0078	0.0075	0.4643
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0078	0.0075	0.0067
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0075	0.0478
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.006	0.004	0.0032
Trypanosoma cruzi	hypothetical protein	0.0078	0.0075	0.6226
Echinococcus multilocularis	Immunoglobulin	0.0098	0.0113	0.0129
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0075	0.0478
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.004	0.0254
Mycobacterium ulcerans	lipase LipD	0.0043	0.0008	0.5
Entamoeba histolytica	PH domain containing protein	0.0078	0.0075	0.023
Schistosoma mansoni	protein kinase	0.006	0.004	0.0032
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.44	0.8366	0.8366
Onchocerca volvulus		0.006	0.004	0.0177
Echinococcus multilocularis	tyrosine protein kinase csk	0.006	0.004	0.0041
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0031	0.0023
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0075	0.0478
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0078	0.0075	0.0083
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0078	0.0075	0.6226
Echinococcus multilocularis	semaphorin 5B	0.0412	0.0715	0.0849
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.006	0.004	0.0041
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Echinococcus granulosus	regulator of G protein signaling 7	0.0851	0.1558	0.1857
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Brugia malayi	DNA-binding protein LAG-1	0.0181	0.0271	0.0266
Loa Loa (eye worm)	TK/ROR protein kinase	0.006	0.004	0.0034
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0099	0.0115	1
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Echinococcus granulosus	DCC interacting protein 13 beta	0.0078	0.0075	0.0083
Entamoeba histolytica	PH domain containing protein	0.0078	0.0075	0.023
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0075	0.0069
Echinococcus granulosus	defective proboscis extension response	0.0098	0.0113	0.0129
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Brugia malayi	PH domain containing protein	0.0078	0.0075	0.0069
Leishmania major	hypothetical protein, conserved	0.0078	0.0075	0.6226
Loa Loa (eye worm)	TK protein kinase	0.006	0.004	0.0034
Trichomonas vaginalis	centaurin beta, putative	0.0078	0.0075	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0412	0.0715	0.071
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0078	0.0075	0.0069
Brugia malayi	beta-lactamase family protein	0.0043	0.0008	0.0003
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.006	0.004	0.0041
Entamoeba histolytica	hypothetical protein	0.0851	0.1558	1
Trichomonas vaginalis	protein kinase atn1, putative	0.006	0.004	0.0254
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0851	0.1558	0.1554
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Echinococcus granulosus	axis inhibition protein axin	0.0851	0.1558	0.1857
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.006	0.004	0.0041
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0081	0.008	0.6729
Brugia malayi	PH domain containing protein	0.0078	0.0075	0.0069
Plasmodium vivax	tyrosine kinase-like protein, putative	0.006	0.004	0.2955
Loa Loa (eye worm)	TK protein kinase	0.006	0.004	0.0034
Brugia malayi	PH domain containing protein	0.0078	0.0075	0.0069
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Brugia malayi	Dynamin	0.0078	0.0075	0.0069
Entamoeba histolytica	hypothetical protein	0.0181	0.0271	0.1524
Trichomonas vaginalis	conserved hypothetical protein	0.0851	0.1558	1
Echinococcus granulosus	activated cdc42 kinase 1	0.006	0.004	0.0041
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0075	0.0478
Brugia malayi	regulator of G-protein signaling egl-10	0.0851	0.1558	0.1554
Echinococcus granulosus	retinal guanylyl cyclase 2	0.006	0.004	0.0041
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0098	0.0113	0.0105
Loa Loa (eye worm)	hypothetical protein	0.006	0.004	0.0034
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Plasmodium vivax	PH domain containing protein	0.0078	0.0075	0.6226
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.004	0.0254
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Schistosoma mansoni	hypothetical protein	0.0181	0.0271	0.0263
Trichomonas vaginalis	protein tyrosine kinase, putative	0.006	0.004	0.0254
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Schistosoma mansoni	serine/threonine-protein kinase	0.0099	0.0115	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0008	0.0003
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.006	0.004	0.0254
Echinococcus granulosus	epidermal growth factor receptor	0.006	0.004	0.0041
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Brugia malayi	beta-lactamase	0.0043	0.0008	0.0003
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Schistosoma mansoni	rho gtpase activating protein	0.0078	0.0075	0.0067
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0078	0.0075	0.0083
Echinococcus multilocularis	axis inhibition protein axin	0.0851	0.1558	0.1857
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0099	0.0115	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.006	0.004	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0412	0.0715	0.071
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0075	0.0069
Echinococcus granulosus	beta 1 syntrophin	0.0078	0.0075	0.0083
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.006	0.004	0.0034
Loa Loa (eye worm)	cytohesin 3	0.0078	0.0075	0.0069
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.006	0.004	0.0041
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.006	0.004	0.0041
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.0086	0.0307
Echinococcus granulosus	integrin linked protein kinase	0.006	0.004	0.0041
Loa Loa (eye worm)	sema domain-containing protein	0.0412	0.0715	0.071
Brugia malayi	Syntrophin-1	0.0078	0.0075	0.0069
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Schistosoma mansoni	centaurin alpha	0.0078	0.0075	0.0067
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Toxoplasma gondii	AtPH1 family protein	0.0078	0.0075	0.6226
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Echinococcus multilocularis	beta 1 syntrophin	0.0078	0.0075	0.0083
Onchocerca volvulus		0.0078	0.0075	0.0373
Brugia malayi	hypothetical protein	0.0851	0.1558	0.1554
Onchocerca volvulus		0.006	0.004	0.0177
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0084	0.0086	0.0097
Brugia malayi	plexin A	0.1153	0.2136	0.2132
Leishmania major	hypothetical protein, conserved	0.006	0.004	0.2955
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0181	0.0271	0.174
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Echinococcus multilocularis	tyrosine protein kinase csk	0.006	0.004	0.0041
Echinococcus multilocularis	Pleckstrin y	0.0078	0.0075	0.0083
Trypanosoma brucei	protein kinase, putative	0.0099	0.0115	1
Brugia malayi	regulator of G-protein signaling rgs-7	0.0851	0.1558	0.1554
Entamoeba histolytica	protein kinase , putative	0.0084	0.0086	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0181	0.0271	0.0266
Schistosoma mansoni	goodpasture antigen-binding protein	0.0078	0.0075	0.0067
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.44	0.8366	0.8366
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0065	0.0049	0.0053
Onchocerca volvulus		0.006	0.004	0.0177
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Echinococcus granulosus	Rho GTPase activating protein 24	0.0078	0.0075	0.0083
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Entamoeba histolytica	hypothetical protein	0.0181	0.0271	0.1524
Trypanosoma cruzi	Protein kinase B	0.0099	0.0115	1
Trichomonas vaginalis	AGC family protein kinase	0.0084	0.0086	0.0553
Loa Loa (eye worm)	TK/Met protein kinase	0.006	0.004	0.0034
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0851	0.1558	1
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0075	0.0478
Brugia malayi	PH domain containing protein	0.0078	0.0075	0.0069
Brugia malayi	Plexin repeat family protein	0.0972	0.179	0.1785
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Echinococcus granulosus	retinal guanylyl cyclase 2	0.006	0.004	0.0041
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Schistosoma mansoni	zinc finger protein	0.0078	0.0075	0.0067
Brugia malayi	hypothetical protein	0.006	0.004	0.0034
Schistosoma mansoni	fibrocystin l	0.0181	0.0271	0.0263
Echinococcus multilocularis	regulator of G protein signaling	0.0851	0.1558	0.1857
Trichomonas vaginalis	centaurin/arf, putative	0.0078	0.0075	0.0478
Brugia malayi	Raf kinase	0.006	0.004	0.0034
Echinococcus granulosus	plexin a4	0.1153	0.2136	0.2548
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0075	0.0069
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0099	0.0115	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.006	0.004	0.0254
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0008	0.5
Schistosoma mansoni	protein kinase	0.0081	0.008	0.0072
Trichomonas vaginalis	conserved hypothetical protein	0.0851	0.1558	1
Toxoplasma gondii	Oxysterol-binding protein	0.0078	0.0075	0.6226
Schistosoma mansoni	syntrophin	0.0078	0.0075	0.0067
Echinococcus multilocularis	pdz domain containing protein	0.0078	0.0075	0.0083
Schistosoma mansoni	serine/threonine protein kinase	0.4025	0.7648	0.7646
Echinococcus multilocularis	regulator of G protein signaling 3	0.0851	0.1558	0.1857
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0078	0.0075	0.4643
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0851	0.1558	0.1551
Toxoplasma gondii	aurora kinase	0.0084	0.0086	0.7319
Schistosoma mansoni	hypothetical protein	0.0412	0.0715	0.0708
Schistosoma mansoni	hypothetical protein	0.056	0.0999	0.0992
Echinococcus granulosus	semaphorin 1A	0.0412	0.0715	0.0849
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0078	0.0075	0.0083
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0099	0.0115	0.011
Schistosoma mansoni	regulator of G protein signaling	0.0851	0.1558	0.1551
Schistosoma mansoni	protein kinase	0.006	0.004	0.0032
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0078	0.0075	0.0067
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Echinococcus granulosus	beta-adrenergic receptor kinase	0.4025	0.7648	0.914
Loa Loa (eye worm)	TK protein kinase	0.006	0.004	0.0034
Brugia malayi	Sema domain containing protein	0.0412	0.0715	0.071
Schistosoma mansoni	plexin	0.056	0.0999	0.0992
Entamoeba histolytica	protein kinase, putative	0.0099	0.0115	0.0495
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.004	0.0034
Loa Loa (eye worm)	syntrophin-1	0.0078	0.0075	0.0069
Entamoeba histolytica	protein kinase, putative	0.0099	0.0115	0.0495
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0851	0.1558	0.1857
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0113	0.0108
Loa Loa (eye worm)	RGC/RGC protein kinase	0.006	0.004	0.0034
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0075	0.0478
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.006	0.004	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0075	0.0069
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0181	0.0271	0.0266
Schistosoma mansoni	dynamin	0.0078	0.0075	0.0067
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.004	0.0034
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Brugia malayi	Variant SH3 domain containing protein	0.0078	0.0075	0.0069
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Echinococcus multilocularis	regulator of G protein signaling 7	0.0851	0.1558	0.1857
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Echinococcus multilocularis	activated cdc42 kinase 1	0.006	0.004	0.0041
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0075	0.0478
Echinococcus multilocularis	tyrosine protein kinase Blk	0.006	0.004	0.0041
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0158	0.0228	0.0223
Echinococcus granulosus	tyrosine protein kinase Fyn	0.006	0.004	0.0041
Schistosoma mansoni	hypothetical protein	0.0078	0.0075	0.0067
Brugia malayi	Receptor family ligand binding region containing protein	0.006	0.004	0.0034
Entamoeba histolytica	protein kinase, putative	0.0099	0.0115	0.0495
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0099	0.0115	0.0495
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Echinococcus multilocularis	plexin a4	0.1153	0.2136	0.2548
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Entamoeba histolytica	hypothetical protein	0.0851	0.1558	1
Trypanosoma cruzi	protein kinase, putative	0.006	0.004	0.2955
Loa Loa (eye worm)	hypothetical protein	0.0851	0.1558	0.1554
Schistosoma mansoni	ephrin receptor	0.0065	0.0049	0.0041
Loa Loa (eye worm)	TK protein kinase	0.006	0.004	0.0034
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.006	0.004	0.0034
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0099	0.0115	0.0495
Echinococcus granulosus	ephrin type A receptor 4 A	0.006	0.004	0.0041
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.004	0.0034
Entamoeba histolytica	hypothetical protein	0.0078	0.0075	0.023
Schistosoma mansoni	hypothetical protein	0.0412	0.0715	0.0708
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0031	0.0023
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0099	0.0115	1
Onchocerca volvulus	Tyrosine kinase homolog	0.006	0.004	0.0177
Onchocerca volvulus		0.006	0.004	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0008	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0851	0.1558	0.1554
Trichomonas vaginalis	kinesin light chain, putative	0.0078	0.0075	0.0478
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.004	0.0034
Brugia malayi	probable spectrin beta chain	0.0078	0.0075	0.0069
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0078	0.0075	0.0069
Brugia malayi	Protein kinase domain containing protein	0.0326	0.055	0.0545
Echinococcus granulosus	raf serine:threonine protein kinase	0.006	0.004	0.0041
Onchocerca volvulus	Putative zinc finger protein	0.0078	0.0075	0.0373
Echinococcus granulosus	tyrosine protein kinase Fyn	0.006	0.004	0.0041
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Leishmania major	protein kinase, putative	0.0099	0.0115	1
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0078	0.0075	0.0083
Schistosoma mansoni	plexin	0.0972	0.179	0.1783
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.006	0.004	0.0041
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0098	0.0113	0.0129
Echinococcus granulosus	roundabout 2	0.0104	0.0123	0.0141
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Echinococcus granulosus	tyrosine protein kinase Fyn	0.006	0.004	0.0041
Entamoeba histolytica	hypothetical protein	0.0851	0.1558	1
Echinococcus granulosus	protein kinase	0.006	0.004	0.0041
Schistosoma mansoni	vav2	0.0078	0.0075	0.0067
Echinococcus multilocularis	raf serine:threonine protein kinase	0.006	0.004	0.0041
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0008	0.0052
Entamoeba histolytica	hypothetical protein	0.0099	0.0115	0.0495
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0078	0.0075	0.6226
Echinococcus multilocularis	protein tyrosine kinase	0.006	0.004	0.0041
Loa Loa (eye worm)	sema domain-containing protein	0.0412	0.0715	0.071
Trichomonas vaginalis	conserved hypothetical protein	0.0181	0.0271	0.174
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0075	0.0069
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Giardia lamblia	Aurora kinase	0.0084	0.0086	1
Echinococcus granulosus	regulator of G protein signaling 3	0.0851	0.1558	0.1857
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Onchocerca volvulus		0.006	0.004	0.0177
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Echinococcus multilocularis	neuroglian	0.0098	0.0113	0.0129
Trichomonas vaginalis	hypothetical protein	0.0078	0.0075	0.0478
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0078	0.0075	0.6226
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0078	0.0075	0.4643
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.4025	0.7648	0.7646
Schistosoma mansoni	hypothetical protein	0.0078	0.0075	0.0067
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.006	0.004	0.0041
Onchocerca volvulus		0.0078	0.0075	0.0373
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0078	0.0075	0.023
Schistosoma mansoni	protein kinase	0.006	0.004	0.0032
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0031	0.0025
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0099	0.0115	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0008	0.5
Trypanosoma cruzi	hypothetical protein	0.0078	0.0075	0.6226
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0075	0.0069
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0031	0.0023
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Onchocerca volvulus		0.006	0.004	0.0177
Echinococcus granulosus	expressed protein	0.0851	0.1558	0.1857
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Echinococcus granulosus	Oxysterol binding protein 11	0.0078	0.0075	0.0083
Schistosoma mansoni	regulator of G protein signaling	0.0851	0.1558	0.1551
Brugia malayi	Oxysterol-binding protein	0.0078	0.0075	0.0069
Echinococcus granulosus	tyrosine protein kinase ABL1	0.006	0.004	0.0041
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Brugia malayi	hypothetical protein	0.0851	0.1558	0.1554
Echinococcus granulosus	exocyst complex component 2	0.0181	0.0271	0.0318
Onchocerca volvulus	outspread protein homolog	0.0078	0.0075	0.0373
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Leishmania major	protein kinase, putative	0.0081	0.008	0.6729
Trypanosoma cruzi	hypothetical protein	0.0078	0.0075	0.6226
Entamoeba histolytica	protein kinase, putative	0.0099	0.0115	0.0495
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0078	0.0075	0.0069
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Loa Loa (eye worm)	PH domain-containing protein	0.0078	0.0075	0.0069
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0099	0.0115	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.006	0.004	0.0254
Loa Loa (eye worm)	PXA domain-containing protein	0.0851	0.1558	0.1554
Schistosoma mansoni	voltage-gated potassium channel	0.0046	0.0013	0.0005
Onchocerca volvulus		0.0078	0.0075	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0113	0.0108
Loa Loa (eye worm)	RGC/RGC protein kinase	0.006	0.004	0.0034
Trypanosoma cruzi	PH domain containing protein, putative	0.0078	0.0075	0.6226
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Loa Loa (eye worm)	hypothetical protein	0.0851	0.1558	0.1554
Onchocerca volvulus		0.0412	0.0715	0.397
Echinococcus multilocularis	Immunoglobulin	0.0098	0.0113	0.0129
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0078	0.0075	0.023
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Entamoeba histolytica	hypothetical protein	0.0078	0.0075	0.023
Brugia malayi	C-terminal src kinase protein 1	0.006	0.004	0.0034
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0008	0.0003
Echinococcus multilocularis	activin receptor type	0.0081	0.008	0.0089
Brugia malayi	Furin-like cysteine rich region family protein	0.006	0.004	0.0034
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0181	0.0271	0.174
Loa Loa (eye worm)	hypothetical protein	0.006	0.004	0.0034
Brugia malayi	PH domain containing protein	0.0078	0.0075	0.0069
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.006	0.004	0.0032
Echinococcus granulosus	regulator of G protein signaling 7	0.0851	0.1558	0.1857
Trypanosoma cruzi	aurora B kinase, putative	0.0084	0.0086	0.7319
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0099	0.0115	1
Echinococcus granulosus	insulin receptor	0.006	0.004	0.0041
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0031	0.0025
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Echinococcus granulosus	regulator of G protein signaling 3	0.0851	0.1558	0.1857
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.006	0.004	0.0041
Loa Loa (eye worm)	TK/FAK protein kinase	0.006	0.004	0.0034
Trichomonas vaginalis	conserved hypothetical protein	0.0851	0.1558	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0008	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0412	0.0715	0.071
Schistosoma mansoni	tyrosine kinase	0.006	0.004	0.0032
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0008	0.0052
Schistosoma mansoni	serine/threonine-protein kinase	0.0099	0.0115	0.0107
Onchocerca volvulus	Protein melted homolog	0.0078	0.0075	0.0373
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Schistosoma mansoni	oxysterol-binding protein 1	0.0078	0.0075	0.0067
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Echinococcus granulosus	retinal guanylyl cyclase 2	0.006	0.004	0.0041
Brugia malayi	Fibronectin type III domain containing protein	0.0104	0.0123	0.0118
Echinococcus multilocularis	receptor type guanylyl cyclase	0.006	0.004	0.0041
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0065	0.0049	0.0053
Trypanosoma cruzi	PH domain containing protein, putative	0.0078	0.0075	0.6226
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0078	0.0075	0.0067
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0851	0.1558	0.1857
Loa Loa (eye worm)	hypothetical protein	0.056	0.0999	0.0994
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.006	0.004	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0075	0.0069
Echinococcus granulosus	tyrosine kinase	0.006	0.004	0.0041
Echinococcus granulosus	Pleckstrin y	0.0078	0.0075	0.0083
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Trichomonas vaginalis	AGC family protein kinase	0.0099	0.0115	0.0737
Loa Loa (eye worm)	TK/EPH protein kinase	0.006	0.004	0.0034
Trichomonas vaginalis	CAMK family protein kinase	0.006	0.004	0.0254
Brugia malayi	PH domain containing protein	0.0078	0.0075	0.0069
Brugia malayi	Protein kinase domain containing protein	0.006	0.004	0.0034
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Loa Loa (eye worm)	hypothetical protein	0.006	0.004	0.0034
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0851	0.1558	0.1857
Loa Loa (eye worm)	hypothetical protein	0.0412	0.0715	0.071
Echinococcus multilocularis	tyrosine protein kinase Srms	0.006	0.004	0.0041
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Plasmodium vivax	protein kinase, putative	0.006	0.004	0.2955
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0075	0.0478
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.004	0.0034
Trichomonas vaginalis	TKL family protein kinase	0.006	0.004	0.0254
Echinococcus multilocularis	c src tyrosine kinase	0.006	0.004	0.0041
Toxoplasma gondii	STE kinase	0.006	0.004	0.2955
Echinococcus granulosus	tyrosine kinase	0.006	0.004	0.0041
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0078	0.0075	0.0069
Brugia malayi	TBC domain containing protein	0.0078	0.0075	0.0069
Brugia malayi	integrin-linked kinase	0.006	0.004	0.0034
Loa Loa (eye worm)	TK/DDR protein kinase	0.006	0.004	0.0034
Trypanosoma cruzi	hypothetical protein	0.0078	0.0075	0.6226
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0081	0.008	0.0089
Schistosoma mansoni	nephrin	0.0104	0.0123	0.0115
Schistosoma mansoni	protein kinase	0.006	0.004	0.0032
Trichomonas vaginalis	conserved hypothetical protein	0.0181	0.0271	0.174
Entamoeba histolytica	protein kinase, putative	0.0099	0.0115	0.0495
Onchocerca volvulus		0.0078	0.0075	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0075	0.0069
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.006	0.004	0.2955
Echinococcus granulosus	aurora kinase A	0.0084	0.0086	0.0097

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 7.9433 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1535725

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1383742