TDR Targets

Basic information

Technical information

TDR Targets ID: 1384119
Name: ethyl 2-(3-methylimidazo[5,4-b]pyridin-2-yl)s ulfanylacetate
MW: 251.305 | Formula: C11H13N3O2S
H donors: 0 H acceptors: 3 LogP: 1.83 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)CSc1nc2c(n1C)nccc2
InChi: 1S/C11H13N3O2S/c1-3-16-9(15)7-17-11-13-8-5-4-6-12-10(8)14(11)2/h4-6H,3,7H2,1-2H3
InChiKey: QPHCTLAVNIBUOZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[(3-methyl-2-imidazo[5,4-b]pyridinyl)thio]acetic acid ethyl ester
2-[(3-methylimidazo[5,4-b]pyridin-2-yl)thio]acetic acid ethyl ester
ethyl 2-(3-methylimidazo[5,4-b]pyridin-2-yl)sulfanylethanoate
SMR000286175
(3-Methyl-3H-imidazo[4,5-b]pyridin-2-ylsulfanyl)-acetic acid ethyl ester
ASN 05923387
ZINC04852714
MLS000677420

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TK/ACK protein kinase	0.0057	0.0056	0.0056
Leishmania major	protein kinase, putative	0.0086	0.012	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0056	0.0056
Brugia malayi	Uncoordinated protein 104	0.0068	0.0079	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0079	0.0079
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.074	0.1562	0.1561
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0068	0.0079	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0079	0.0079
Schistosoma mansoni	protein kinase	0.0076	0.0096	0.0095
Brugia malayi	hypothetical protein	0.0378	0.0762	0.0761
Schistosoma mansoni	rho gtpase activating protein	0.0068	0.0079	0.0078
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Trypanosoma brucei	protein kinase, putative	0.0076	0.0096	0.6349
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0086	0.012	0.0423
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0076	0.0096	0.6349
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0057	0.0056	0.0065
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.0294	0.1829
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.074	0.1562	0.1562
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0056	0.0056
Schistosoma mansoni	semaphorin 5-related	0.0378	0.0762	0.0761
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Entamoeba histolytica	hypothetical protein	0.0165	0.0294	0.1583
Trichomonas vaginalis	conserved hypothetical protein	0.074	0.1562	1
Brugia malayi	SH2 domain containing protein	0.0057	0.0056	0.0055
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0057	0.0056	0.0055
Echinococcus multilocularis	FL cytokine receptor	0.0057	0.0056	0.0065
Echinococcus granulosus	tyrosine protein kinase Srms	0.0057	0.0056	0.0065
Toxoplasma gondii	Oxysterol-binding protein	0.0068	0.0079	0.3651
Entamoeba histolytica	protein kinase domain containing protein	0.0082	0.011	0.0361
Schistosoma mansoni	axis inhibition protein axin	0.074	0.1562	0.1561
Loa Loa (eye worm)	hypothetical protein	0.074	0.1562	0.1562
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0079	0.0442
Entamoeba histolytica	hypothetical protein	0.0165	0.0294	0.1583
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0188	0.0188
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0086	0.012	1
Brugia malayi	Dynamin	0.0068	0.0079	0.0078
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0086	0.012	1
Schistosoma mansoni	protein kinase	0.0057	0.0056	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0079	0.0079
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Brugia malayi	PH domain containing protein	0.0068	0.0079	0.0078
Entamoeba histolytica	hypothetical protein	0.0086	0.012	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0079	0.0079
Brugia malayi	Oxysterol binding protein	0.0068	0.0079	0.0078
Loa Loa (eye worm)	TK/EPH protein kinase	0.0057	0.0056	0.0056
Brugia malayi	PH domain containing protein	0.0068	0.0079	0.0078
Trichomonas vaginalis	centaurin beta, putative	0.0068	0.0079	0.0442
Toxoplasma gondii	hypothetical protein	0.0068	0.0079	0.3651
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0082	0.011	0.013
Loa Loa (eye worm)	syntrophin-1	0.0068	0.0079	0.0079
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0079	0.0442
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.0056	0.0055
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0056	0.0292
Onchocerca volvulus	Tyrosine kinase homolog	0.0057	0.0056	0.0289
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0056	0.0056
Onchocerca volvulus		0.0057	0.0056	0.0289
Entamoeba histolytica	protein kinase domain containing protein	0.0076	0.0096	0.0268
Echinococcus granulosus	Pleckstrin y	0.0068	0.0079	0.0093
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0057	0.0056	0.0292
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0056	0.0056
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Entamoeba histolytica	hypothetical protein	0.0068	0.0079	0.0154
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0039	0.0016	0.0018
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0068	0.0079	0.0154
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Onchocerca volvulus		0.0068	0.0079	0.0412
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Schistosoma mansoni	voltage-gated potassium channel	0.0043	0.0024	0.0023
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Trypanosoma cruzi	Protein kinase B	0.0086	0.012	1
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0068	0.0079	0.0154
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0056	0.0056
Onchocerca volvulus		0.0057	0.0056	0.0289
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0068	0.0079	0.0093
Echinococcus granulosus	transcription factor collier	0.0165	0.0294	0.035
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.011	0.0642
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0068	0.0079	0.0412
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0057	0.0056	0.0055
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0057	0.0056	0.0065
Echinococcus multilocularis	regulator of G protein signaling	0.074	0.1562	0.1866
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0068	0.0079	0.0093
Toxoplasma gondii	AtPH1 family protein	0.0068	0.0079	0.3651
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0057	0.0056	0.0065
Echinococcus granulosus	defective proboscis extension response	0.0117	0.0188	0.0223
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0117	0.0188	0.0186
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0057	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0198	0.0198
Brugia malayi	TBC domain containing protein	0.0068	0.0079	0.0078
Leishmania major	protein kinase, putative	0.0076	0.0096	0.6349
Brugia malayi	Furin-like cysteine rich region family protein	0.0057	0.0056	0.0055
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0056	0.0056
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0117	0.0188	0.0223
Echinococcus granulosus	tyrosine kinase	0.0057	0.0056	0.0065
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0056	0.0292
Echinococcus multilocularis	activated cdc42 kinase 1	0.0057	0.0056	0.0065
Loa Loa (eye worm)	hypothetical protein	0.074	0.1562	0.1562
Schistosoma mansoni	ephrin receptor	0.0057	0.0056	0.0055
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0086	0.012	1
Loa Loa (eye worm)	hypothetical protein	0.0378	0.0762	0.0762
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0056	0.0056
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0057	0.0056	0.0065
Schistosoma mansoni	fibrocystin l	0.0165	0.0294	0.0293
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0057	0.0056	0.0065
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0079	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0079	0.0079
Echinococcus granulosus	kinase suppressor of Ras 1	0.0057	0.0056	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0079	0.0079
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0056	0.0056
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0079	0.0442
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0056	0.0292
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0378	0.0762	0.0762
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0057	0.0056	0.0065
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0079	0.0442
Echinococcus granulosus	tyrosine kinase	0.0057	0.0056	0.0065
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0057	0.0056	0.0065
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Onchocerca volvulus		0.0068	0.0079	0.0412
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0068	0.0079	0.3651
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0068	0.0079	0.0442
Trichomonas vaginalis	kinesin light chain, putative	0.0068	0.0079	0.0442
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0057	0.0056	0.0065
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0068	0.0079	0.0093
Schistosoma mansoni	serine/threonine RGC	0.0057	0.0056	0.0055
Echinococcus multilocularis	roundabout 2	0.0122	0.0198	0.0235
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0057	0.0056	0.0055
Loa Loa (eye worm)	AUR protein kinase	0.0082	0.011	0.011
Echinococcus granulosus	tyrosine kinase	0.0057	0.0056	0.0065
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Echinococcus granulosus	ephrin type A receptor 4 A	0.0057	0.0056	0.0065
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0039	0.0016	0.0015
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0057	0.0056	0.0065
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Entamoeba histolytica	protein kinase, putative	0.0086	0.012	0.0423
Brugia malayi	hypothetical protein	0.0057	0.0056	0.0055
Loa Loa (eye worm)	uncoordinated protein 104	0.0068	0.0079	0.0079
Echinococcus multilocularis	oxysterol binding protein 1	0.0068	0.0079	0.0093
Echinococcus granulosus	activin receptor type	0.0076	0.0096	0.0114
Onchocerca volvulus		0.0033	0.0003	0.0009
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0068	0.0079	0.0078
Plasmodium falciparum	PH domain-containing protein, putative	0.0068	0.0079	0.3651
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0056	0.0056
Loa Loa (eye worm)	Plekhf2 protein	0.0068	0.0079	0.0079
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0068	0.0079	0.0093
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0068	0.0079	0.0078
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0056	0.0056
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0056	0.0056
Echinococcus granulosus	beta-adrenergic receptor kinase	0.3498	0.7649	0.9141
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.0294	0.1829
Onchocerca volvulus		0.0068	0.0079	0.0412
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0068	0.0079	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0079	0.0079
Echinococcus granulosus	tyrosine protein kinase HCK	0.0057	0.0056	0.0065
Loa Loa (eye worm)	RGS-3 protein	0.074	0.1562	0.1562
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0057	0.0056	0.0065
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0056	0.0056
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0068	0.0079	0.0079
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0056	0.0056
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0122	0.0198	0.0197
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0086	0.012	1
Entamoeba histolytica	protein kinase, putative	0.0082	0.011	0.0361
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0068	0.0079	0.0154
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0068	0.0079	0.0154
Echinococcus multilocularis	beta 1 syntrophin	0.0068	0.0079	0.0093
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0057	0.0056	0.0056
Trypanosoma cruzi	hypothetical protein	0.0068	0.0079	0.3651
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0209	0.0391	0.0391
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0057	0.0056	0.0055
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Brugia malayi	hypothetical protein	0.0068	0.0079	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0056	0.0056
Schistosoma mansoni	hypothetical protein	0.0165	0.0294	0.0293
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Onchocerca volvulus		0.0057	0.0056	0.0289
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0086	0.012	0.0423
Schistosoma mansoni	protein kinase	0.0057	0.0056	0.0055
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0057	0.0056	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0889	0.1892	0.1892
Onchocerca volvulus		0.0057	0.0056	0.0289
Echinococcus granulosus	dynamin 1	0.0068	0.0079	0.0093
Echinococcus granulosus	axis inhibition protein axin	0.074	0.1562	0.1866
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0056	0.0056
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.0294	0.1829
Schistosoma mansoni	hypothetical protein	0.0068	0.0079	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0056	0.0056
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0086	0.012	0.0423
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.011	0.0642
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0057	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.074	0.1562	0.1562
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0056	0.0292
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0086	0.012	0.0423
Schistosoma mansoni	cell adhesion molecule	0.0122	0.0198	0.0197
Schistosoma mansoni	hypothetical protein	0.0068	0.0079	0.0078
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0057	0.0056	0.0055
Brugia malayi	Tyrosine-protein kinase PR2	0.0057	0.0056	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0001	0.0001
Echinococcus granulosus	regulator of G protein signaling 3	0.074	0.1562	0.1866
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Brugia malayi	SH2 domain containing protein	0.0057	0.0056	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0198	0.0198
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0057	0.0056	0.0065
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0068	0.0079	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Trichomonas vaginalis	centaurin alpha, putative	0.0068	0.0079	0.0442
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Trichomonas vaginalis	conserved hypothetical protein	0.074	0.1562	1
Brugia malayi	Raf kinase	0.0057	0.0056	0.0055
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trypanosoma brucei	aurora B kinase	0.0082	0.011	0.8531
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0005	0.0005
Giardia lamblia	Aurora kinase	0.0082	0.011	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0057	0.0056	0.0055
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0068	0.0079	0.0093
Echinococcus multilocularis	tyrosine protein kinase csk	0.0057	0.0056	0.0065
Trichomonas vaginalis	protein transport protein sec7, putative	0.0068	0.0079	0.0442
Echinococcus granulosus	myotubularin protein 13	0.0068	0.0079	0.0093
Echinococcus multilocularis	oxysterol binding protein 3	0.0068	0.0079	0.0093
Brugia malayi	Regulator of G protein signaling domain containing protein	0.074	0.1562	0.1561
Entamoeba histolytica	PH domain containing protein	0.0068	0.0079	0.0154
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Brugia malayi	Probable exocyst complex component Sec5	0.0165	0.0294	0.0293
Echinococcus granulosus	raf serine:threonine protein kinase	0.0057	0.0056	0.0065
Leishmania major	protein kinase, putative	0.0082	0.011	0.8531
Echinococcus granulosus	roundabout 2	0.0122	0.0198	0.0235
Schistosoma mansoni	regulator of G protein signaling	0.074	0.1562	0.1561
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0188	0.0188
Schistosoma mansoni	protein kinase	0.0076	0.0096	0.0095
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0057	0.0056	0.0055
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0057	0.0056	0.0056
Brugia malayi	ephrin receptor 1 precursor	0.0057	0.0056	0.0055
Echinococcus granulosus	Oxysterol binding protein 11	0.0068	0.0079	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0056	0.0056
Entamoeba histolytica	hypothetical protein	0.0068	0.0079	0.0154
Echinococcus granulosus	serine/threonine protein kinase	0.0086	0.012	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0378	0.0762	0.0762
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0057	0.0056	0.0056
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0079	0.0442
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0068	0.0079	0.0079
Echinococcus multilocularis	tyrosine protein kinase csk	0.0057	0.0056	0.0065
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.3824	0.8367	1
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0068	0.0079	0.0154
Loa Loa (eye worm)	serine/threonine protein kinase	0.0057	0.0056	0.0056
Brugia malayi	integrin-linked kinase	0.0057	0.0056	0.0055
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0056	0.0056
Echinococcus multilocularis	protein kinase	0.0057	0.0056	0.0065
Entamoeba histolytica	protein kinase, putative	0.0086	0.012	0.0423
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Entamoeba histolytica	hypothetical protein	0.074	0.1562	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0057	0.0056	0.0065
Plasmodium falciparum	protein kinase, putative	0.0076	0.0096	0.6349
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0068	0.0079	0.3651
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0057	0.0056	0.0065
Schistosoma mansoni	zinc finger protein	0.0068	0.0079	0.0078
Brugia malayi	hypothetical protein	0.0057	0.0056	0.0055
Echinococcus multilocularis	Immunoglobulin	0.0117	0.0188	0.0223
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0057	0.0056	0.0065
Schistosoma mansoni	z-protein (S1r protein)	0.074	0.1562	0.1561
Schistosoma mansoni	tyrosine protein kinase	0.0057	0.0056	0.0055
Schistosoma mansoni	hypothetical protein	0.0068	0.0079	0.0078
Echinococcus granulosus	GRB2 associated binding protein 3	0.0068	0.0079	0.0093
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.0294	0.1829
Brugia malayi	C-terminal src kinase protein 1	0.0057	0.0056	0.0055
Schistosoma mansoni	hypothetical protein	0.0378	0.0762	0.0761
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Brugia malayi	Dynamin	0.0068	0.0079	0.0078
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.0056	0.0055
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0068	0.0079	0.0079
Echinococcus granulosus	exocyst complex component 2	0.0165	0.0294	0.035
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Echinococcus multilocularis	pdz domain containing protein	0.0068	0.0079	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0086	0.012	1
Echinococcus multilocularis	axis inhibition protein axin	0.074	0.1562	0.1866
Echinococcus multilocularis	protein tyrosine kinase	0.0057	0.0056	0.0065
Loa Loa (eye worm)	PXA domain-containing protein	0.074	0.1562	0.1562
Entamoeba histolytica	hypothetical protein	0.0165	0.0294	0.1583
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Loa Loa (eye worm)	TK/ROR protein kinase	0.0057	0.0056	0.0056
Echinococcus multilocularis	tyrosine protein kinase	0.0057	0.0056	0.0065
Echinococcus granulosus	regulator of G protein signaling 7	0.074	0.1562	0.1866
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0056	0.0056
Schistosoma mansoni	serine/threonine protein kinase	0.0082	0.011	0.0109
Schistosoma mansoni	hypothetical protein	0.0057	0.0056	0.0055
Echinococcus multilocularis	integrin linked protein kinase	0.0057	0.0056	0.0065
Echinococcus multilocularis	Regulator of G protein signaling 20	0.074	0.1562	0.1866
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.3824	0.8367	0.8367
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0086	0.012	1
Echinococcus multilocularis	Pleckstrin y	0.0068	0.0079	0.0093
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0082	0.011	0.0361
Loa Loa (eye worm)	hypothetical protein	0.074	0.1562	0.1562
Toxoplasma gondii	aurora kinase	0.0082	0.011	0.8531
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.074	0.1562	0.1561
Onchocerca volvulus	outspread protein homolog	0.0068	0.0079	0.0412
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0056	0.0056
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Loa Loa (eye worm)	sema domain-containing protein	0.0378	0.0762	0.0762
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0079	0.0079
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0068	0.0079	0.3651
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0057	0.0056	0.0065
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Echinococcus granulosus	Pleckstrin y	0.0068	0.0079	0.0093
Echinococcus granulosus	tyrosine protein kinase csk	0.0057	0.0056	0.0065
Schistosoma mansoni	growth factor receptor-bound protein	0.0068	0.0079	0.0078
Plasmodium vivax	hypothetical protein, conserved	0.0068	0.0079	0.3651
Brugia malayi	Guanylyl cyclase protein 23	0.0057	0.0056	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0378	0.0762	0.0762
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0068	0.0079	0.0154
Schistosoma mansoni	zinc finger protein	0.0068	0.0079	0.0078
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0068	0.0079	0.0078
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0057	0.0056	0.0065
Entamoeba histolytica	PH domain containing protein	0.0068	0.0079	0.0154
Brugia malayi	Cadps2 protein	0.0068	0.0079	0.0078
Schistosoma mansoni	hypothetical protein	0.0068	0.0079	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0079	0.0442
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0086	0.012	1
Loa Loa (eye worm)	sema domain-containing protein	0.0378	0.0762	0.0762
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0057	0.0056	0.0065
Brugia malayi	Pleckstrin Homology Domain	0.0068	0.0079	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0079	0.0442
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0057	0.0056	0.0292
Echinococcus granulosus	epidermal growth factor receptor	0.0057	0.0056	0.0065
Schistosoma mansoni	serine/threonine protein kinase	0.3498	0.7649	0.7648
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0079	0.0079
Echinococcus granulosus	regulator of G protein signaling 3	0.074	0.1562	0.1866
Trypanosoma cruzi	hypothetical protein	0.0068	0.0079	0.3651
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0057	0.0056	0.0056
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Schistosoma mansoni	nephrin	0.0122	0.0198	0.0197
Brugia malayi	MAX-1A	0.0068	0.0079	0.0078
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0086	0.012	1
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0068	0.0079	0.0078
Echinococcus multilocularis	insulin receptor	0.0057	0.0056	0.0065
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0057	0.0056	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0165	0.0294	0.0294
Leishmania major	protein kinase, putative	0.0086	0.012	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0057	0.0056	0.0056
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Schistosoma mansoni	protein kinase	0.0057	0.0056	0.0055
Brugia malayi	Protein kinase domain containing protein	0.0295	0.0581	0.058
Echinococcus granulosus	oxysterol binding protein 9	0.0068	0.0079	0.0093
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.011	0.0642
Entamoeba histolytica	cell surface protease gp63, putative	0.0165	0.0294	0.1583
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0057	0.0056	0.0065
Trichomonas vaginalis	centaurin/arf, putative	0.0068	0.0079	0.0442
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Trypanosoma brucei	protein kinase, putative	0.0086	0.012	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0057	0.0056	0.0056
Loa Loa (eye worm)	TK/RYK protein kinase	0.0057	0.0056	0.0056
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Schistosoma mansoni	regulator of G protein signaling	0.074	0.1562	0.1561
Echinococcus multilocularis	neuroglian	0.0117	0.0188	0.0223
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0068	0.0079	0.0442
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.0294	0.1829
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0057	0.0056	0.0056
Trypanosoma cruzi	PH domain containing protein, putative	0.0068	0.0079	0.3651
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0165	0.0294	0.1829
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0165	0.0294	0.1829
Echinococcus multilocularis	activin receptor type	0.0076	0.0096	0.0114
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0057	0.0056	0.0055
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0001	0.0001
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0068	0.0079	0.0093
Brugia malayi	hypothetical protein	0.074	0.1562	0.1561
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0068	0.0079	0.0412
Onchocerca volvulus		0.0057	0.0056	0.0289
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0068	0.0079	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0378	0.0762	0.0762
Brugia malayi	PH domain containing protein	0.0068	0.0079	0.0078
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Echinococcus granulosus	aurora kinase A	0.0082	0.011	0.013
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Echinococcus multilocularis	epidermal growth factor receptor	0.0057	0.0056	0.0065
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0057	0.0056	0.0065
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0068	0.0079	0.0093
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0057	0.0056	0.0065
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0056	0.0056
Brugia malayi	serine/threonine protein kinase 6	0.0082	0.011	0.0109
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.0421	0.2423
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.0056	0.0055
Onchocerca volvulus		0.0057	0.0056	0.0289
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0068	0.0079	0.3651
Echinococcus multilocularis	myotubularin protein 13	0.0068	0.0079	0.0093
Brugia malayi	Plekhf2 protein	0.0068	0.0079	0.0078
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0057	0.0056	0.0289
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0056	0.0056
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Leishmania major	serine/threonine-protein kinase a, putative	0.0086	0.012	1
Entamoeba histolytica	hypothetical protein	0.0068	0.0079	0.0154
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0086	0.012	0.0423
Echinococcus multilocularis	semaphorin 5B	0.0378	0.0762	0.091
Echinococcus granulosus	insulin receptor	0.0057	0.0056	0.0065
Echinococcus granulosus	Immunoglobulin	0.0117	0.0188	0.0223
Onchocerca volvulus		0.0889	0.1892	1
Toxoplasma gondii	hypothetical protein	0.0068	0.0079	0.3651
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0068	0.0079	0.0442
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0056	0.0292
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0086	0.012	0.0703
Schistosoma mansoni	vav2	0.0068	0.0079	0.0078
Echinococcus multilocularis	exocyst complex component 2	0.0165	0.0294	0.035
Schistosoma mansoni	myotubularin-related protein	0.0068	0.0079	0.0078
Echinococcus granulosus	Regulator of G protein signaling 20	0.074	0.1562	0.1866
Entamoeba histolytica	protein kinase, putative	0.0086	0.012	0.0423
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0057	0.0056	0.0055
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0056	0.0292
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0068	0.0079	0.0093
Schistosoma mansoni	oxysterol-binding protein 1	0.0068	0.0079	0.0078
Plasmodium vivax	PH domain containing protein	0.0068	0.0079	0.3651
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0086	0.012	1
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0056	0.0056
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Brugia malayi	Oxysterol-binding protein	0.0068	0.0079	0.0078
Echinococcus granulosus	pdz domain containing protein	0.0068	0.0079	0.0093
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0062	0.0067	0.0078
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0057	0.0056	0.0055
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Brugia malayi	Plexin repeat family protein	0.0889	0.1892	0.189
Plasmodium falciparum	oxysterol-binding protein, putative	0.0068	0.0079	0.3651
Echinococcus granulosus	cytohesin 1	0.0068	0.0079	0.0093
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0057	0.0056	0.0065
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0068	0.0079	0.0442
Onchocerca volvulus		0.0068	0.0079	0.0412
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0079	0.0442
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0086	0.012	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0056	0.0056
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0057	0.0056	0.0065
Schistosoma mansoni	protein kinase	0.0057	0.0056	0.0055
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0068	0.0079	0.0093
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0057	0.0056	0.0065
Onchocerca volvulus		0.0068	0.0079	0.0412
Loa Loa (eye worm)	oxysterol binding protein	0.0068	0.0079	0.0079
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0057	0.0056	0.0065
Trypanosoma cruzi	hypothetical protein	0.0068	0.0079	0.3651
Schistosoma mansoni	hypothetical protein	0.0068	0.0079	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Echinococcus granulosus	semaphorin 1A	0.0378	0.0762	0.091
Trypanosoma cruzi	NIMA-related kinase, putative	0.0086	0.012	1
Schistosoma mansoni	ephrin receptor	0.0062	0.0067	0.0065
Echinococcus granulosus	receptor type guanylyl cyclase	0.0057	0.0056	0.0065
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0057	0.0056	0.0065
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0057	0.0056	0.0065
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0057	0.0056	0.0065
Onchocerca volvulus		0.0378	0.0762	0.4027
Brugia malayi	Fibronectin type III domain containing protein	0.0122	0.0198	0.0197
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0086	0.012	1
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0068	0.0079	0.3651
Entamoeba histolytica	hypothetical protein	0.0165	0.0294	0.1583
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Entamoeba histolytica	hypothetical protein	0.0086	0.012	0.0423
Echinococcus granulosus	integrin linked protein kinase	0.0057	0.0056	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0165	0.0294	0.0294
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0086	0.012	1
Trichomonas vaginalis	hypothetical protein	0.0068	0.0079	0.0442
Loa Loa (eye worm)	PH domain-containing protein	0.0068	0.0079	0.0079
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Brugia malayi	Regulator of G protein signaling domain containing protein	0.074	0.1562	0.1561
Schistosoma mansoni	plexin	0.0512	0.1059	0.1057
Echinococcus granulosus	protein tyrosine kinase	0.0057	0.0056	0.0065
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0057	0.0056	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0512	0.1059	0.1059
Loa Loa (eye worm)	hypothetical protein	0.074	0.1562	0.1562
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Echinococcus granulosus	regulator of G protein signaling 7	0.074	0.1562	0.1866
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0056	0.0056
Entamoeba histolytica	hypothetical protein, conserved	0.0068	0.0079	0.0154
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.074	0.1562	1
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Schistosoma mansoni	serine/threonine protein kinase	0.3498	0.7649	0.7648
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0079	0.0079
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0082	0.011	0.8531
Loa Loa (eye worm)	TK/ALK protein kinase	0.0295	0.0581	0.0581
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0057	0.0056	0.0065
Trichomonas vaginalis	AGC family protein kinase	0.0082	0.011	0.0642
Schistosoma mansoni	hypothetical protein	0.0512	0.1059	0.1057
Schistosoma mansoni	protein kinase	0.0057	0.0056	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0188	0.0188
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0057	0.0056	0.0292
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0174	0.0314	0.0314
Onchocerca volvulus		0.0068	0.0079	0.0412
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0057	0.0056	0.0055
Echinococcus granulosus	c src tyrosine kinase	0.0057	0.0056	0.0065
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.0294	0.1829
Onchocerca volvulus		0.0068	0.0079	0.0412
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0057	0.0056	0.0065
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0068	0.0079	0.0154
Entamoeba histolytica	protein kinase, putative	0.0086	0.012	0.0423
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Toxoplasma gondii	protein kinase domain-containing protein	0.0086	0.012	1
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0056	0.0292
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0057	0.0056	0.0065
Loa Loa (eye worm)	SRC-1	0.0057	0.0056	0.0056
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0188	0.0188
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0076	0.0096	0.6349
Trypanosoma cruzi	NIMA-related kinase, putative	0.0086	0.012	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0057	0.0056	0.0055
Brugia malayi	hypothetical protein	0.0057	0.0056	0.0055
Echinococcus multilocularis	transcription factor collier	0.0165	0.0294	0.035
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.2758	0.6016	0.7189
Echinococcus granulosus	beta 1 syntrophin	0.0068	0.0079	0.0093
Echinococcus granulosus	natriuretic peptide receptor 1	0.0057	0.0056	0.0065
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0056	0.0056
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Brugia malayi	Tyrosine-protein kinase abl-1	0.0057	0.0056	0.0055
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0056	0.0056
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trypanosoma cruzi	hypothetical protein	0.0068	0.0079	0.3651
Brugia malayi	PH domain containing protein	0.0068	0.0079	0.0078
Trypanosoma cruzi	hypothetical protein	0.0068	0.0079	0.3651
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0057	0.0056	0.0065
Schistosoma mansoni	syntrophin	0.0068	0.0079	0.0078
Loa Loa (eye worm)	hypothetical protein	0.074	0.1562	0.1562
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.3824	0.8367	0.8367
Entamoeba histolytica	protein kinase , putative	0.0082	0.011	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0056	0.0056
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0068	0.0079	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0056	0.0056
Brugia malayi	PH domain containing protein	0.0068	0.0079	0.0078
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0057	0.0056	0.0065
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0068	0.0079	0.0093
Entamoeba histolytica	protein kinase, putative	0.0086	0.012	0.0423
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0056	0.0056
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0068	0.0079	0.0093
Trichomonas vaginalis	CAMK family protein kinase	0.0057	0.0056	0.0292
Leishmania major	hypothetical protein, conserved	0.0068	0.0079	0.3651
Onchocerca volvulus	Protein melted homolog	0.0068	0.0079	0.0412
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0117	0.0188	0.0223
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trichomonas vaginalis	alpha chimerin, putative	0.0068	0.0079	0.0442
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0079	0.0442
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0057	0.0056	0.0065
Echinococcus multilocularis	oxysterol binding protein 9	0.0068	0.0079	0.0093
Trypanosoma brucei	PH domain containing protein, putative	0.0068	0.0079	0.3651
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Schistosoma mansoni	vesicular amine transporter	0.012	0.0193	0.0192
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.0056	0.0055
Brugia malayi	DNA-binding protein LAG-1	0.0165	0.0294	0.0293
Echinococcus multilocularis	regulator of G protein signaling 7	0.074	0.1562	0.1866
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.074	0.1562	0.1866
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0068	0.0079	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0188	0.0188
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0068	0.0079	0.0154
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0057	0.0056	0.0289
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Brugia malayi	regulator of G-protein signaling egl-10	0.074	0.1562	0.1561
Loa Loa (eye worm)	hypothetical protein	0.0165	0.0294	0.0294
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0068	0.0079	0.0154
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0079	0.0442
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Loa Loa (eye worm)	rho-GTPase-activating	0.0068	0.0079	0.0079
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0057	0.0056	0.0065
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0057	0.0056	0.0065
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.074	0.1562	0.1561
Brugia malayi	probable spectrin beta chain	0.0068	0.0079	0.0078
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0057	0.0056	0.0065
Brugia malayi	PH domain containing protein	0.0068	0.0079	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0056	0.0056
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Onchocerca volvulus		0.0057	0.0056	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0079	0.0079
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.3824	0.8367	1
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0057	0.0056	0.0056
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0086	0.012	0.012
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0056	0.0056
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.3824	0.8367	0.8367
Schistosoma mansoni	centaurin alpha	0.0068	0.0079	0.0078
Brugia malayi	PH domain containing protein	0.0068	0.0079	0.0078
Echinococcus multilocularis	transfer RNA-Thr	0.0057	0.0056	0.0065
Schistosoma mansoni	hypothetical protein	0.0165	0.0294	0.0293
Echinococcus granulosus	DCC interacting protein 13 beta	0.0068	0.0079	0.0093
Brugia malayi	PH domain containing protein	0.0068	0.0079	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0079	0.0079
Schistosoma mansoni	protein tyrosine kinase	0.0057	0.0056	0.0055
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0056	0.0056
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0057	0.0056	0.0065
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0057	0.0056	0.0065
Entamoeba histolytica	PH domain containing protein	0.0068	0.0079	0.0154
Entamoeba histolytica	hypothetical protein	0.0068	0.0079	0.0154
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0068	0.0079	0.0093
Echinococcus granulosus	axis inhibition protein axin	0.074	0.1562	0.1866
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0001	0.0001
Schistosoma mansoni	hypothetical protein	0.0205	0.0381	0.038
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0082	0.011	0.8531
Schistosoma mansoni	plexin	0.0889	0.1892	0.189
Echinococcus multilocularis	heat shock protein 70	0.0057	0.0056	0.0065
Onchocerca volvulus		0.0057	0.0056	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0188	0.0188
Brugia malayi	A-kinase anchor protein 10, precursor	0.074	0.1562	0.1561
Echinococcus multilocularis	dynamin 1	0.0068	0.0079	0.0093
Brugia malayi	Variant SH3 domain containing protein	0.0068	0.0079	0.0078
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0068	0.0079	0.0093
Trichomonas vaginalis	conserved hypothetical protein	0.074	0.1562	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0076	0.0096	0.6349
Brugia malayi	Sema domain containing protein	0.0378	0.0762	0.0761
Loa Loa (eye worm)	TK/CSK protein kinase	0.0057	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0198	0.0198
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Echinococcus multilocularis	tyrosine kinase	0.0057	0.0056	0.0065
Trypanosoma cruzi	hypothetical protein	0.0068	0.0079	0.3651
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0057	0.0056	0.0056
Trypanosoma cruzi	PH domain containing protein, putative	0.0068	0.0079	0.3651
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0068	0.0079	0.0093
Echinococcus granulosus	expressed protein	0.074	0.1562	0.1866
Loa Loa (eye worm)	TK/FAK protein kinase	0.0057	0.0056	0.0056
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0057	0.0056	0.0065
Brugia malayi	PXA domain containing protein	0.074	0.1562	0.1561
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Brugia malayi	protein-tyrosine kinase	0.0057	0.0056	0.0055
Schistosoma mansoni	protein kinase	0.0082	0.011	0.0109
Loa Loa (eye worm)	AUR protein kinase	0.0082	0.011	0.011
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0057	0.0056	0.0065
Schistosoma mansoni	goodpasture antigen-binding protein	0.0068	0.0079	0.0078
Trypanosoma cruzi	hypothetical protein	0.0068	0.0079	0.3651
Entamoeba histolytica	protein kinase, putative	0.0086	0.012	0.0423
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trypanosoma cruzi	PH domain containing protein, putative	0.0068	0.0079	0.3651
Echinococcus multilocularis	tyrosine protein kinase shark	0.0057	0.0056	0.0065
Echinococcus multilocularis	plexin a4	0.1055	0.2257	0.2696
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0057	0.0056	0.0065
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0057	0.0056	0.0292
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0057	0.0056	0.0065
Trichomonas vaginalis	centaurin/arf, putative	0.0068	0.0079	0.0442
Echinococcus granulosus	calcium dependent secretion activator 1	0.0068	0.0079	0.0093
Brugia malayi	hypothetical protein	0.0378	0.0762	0.0761
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0079	0.0442
Echinococcus granulosus	neuroglian	0.0117	0.0188	0.0223
Schistosoma mansoni	serine/threonine-protein kinase	0.0086	0.012	0.0118
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0068	0.0079	0.3651
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0079	0.0079
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Onchocerca volvulus		0.0057	0.0056	0.0289
Echinococcus granulosus	tyrosine protein kinase shark	0.0057	0.0056	0.0065
Brugia malayi	IPT/TIG domain containing protein	0.0165	0.0294	0.0293
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0057	0.0056	0.0065
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0057	0.0056	0.0065
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0068	0.0079	0.3651
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0057	0.0056	0.0055
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0068	0.0079	0.0078
Echinococcus multilocularis	aurora kinase A	0.0082	0.011	0.013
Schistosoma mansoni	voltage-gated potassium channel	0.0043	0.0024	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0056	0.0056
Echinococcus multilocularis	axis inhibition protein axin	0.074	0.1562	0.1866
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trichomonas vaginalis	TK family protein kinase	0.0057	0.0056	0.0292
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.074	0.1562	0.1866
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0068	0.0079	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0079	0.0079
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0086	0.012	1
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0086	0.012	1
Echinococcus granulosus	G protein coupled receptor kinase 1	0.2758	0.6016	0.7189
Entamoeba histolytica	protein kinase, putative	0.0086	0.012	0.0423
Echinococcus multilocularis	Pleckstrin y	0.0068	0.0079	0.0093
Leishmania major	hypothetical protein, conserved	0.0068	0.0079	0.3651
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0076	0.0096	0.6349
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0079	0.0442
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Echinococcus multilocularis	epidermal growth factor receptor	0.0057	0.0056	0.0065
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0057	0.0056	0.0065
Echinococcus granulosus	tyrosine protein kinase Blk	0.0057	0.0056	0.0065
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0068	0.0079	0.0093
Echinococcus multilocularis	regulator of G protein signaling 3	0.074	0.1562	0.1866
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.4564	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0057	0.0056	0.0065
Entamoeba histolytica	hypothetical protein	0.074	0.1562	1
Brugia malayi	Variant SH3 domain containing protein	0.0068	0.0079	0.0078
Echinococcus multilocularis	Oxysterol binding protein 11	0.0068	0.0079	0.0093
Brugia malayi	serine/threonine-protein kinase 6	0.0082	0.011	0.0109
Trichomonas vaginalis	STE family protein kinase	0.0057	0.0056	0.0292
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0079	0.0079
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0079	0.0442
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0068	0.0079	0.0154
Brugia malayi	SRC-1	0.0057	0.0056	0.0055
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0076	0.0096	0.0114
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0056	0.0056
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0056	0.0056
Schistosoma mansoni	hypothetical protein	0.0378	0.0762	0.0761
Loa Loa (eye worm)	hypothetical protein	0.0165	0.0294	0.0294
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Brugia malayi	PXA domain containing protein	0.074	0.1562	0.1561
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0082	0.011	0.0361
Echinococcus granulosus	plexin a4	0.1055	0.2257	0.2696
Echinococcus granulosus	Pleckstrin y	0.0068	0.0079	0.0093
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0068	0.0079	0.3651
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0057	0.0056	0.0292
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0057	0.0056	0.0065
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0082	0.011	0.0361
Schistosoma mansoni	dynamin	0.0068	0.0079	0.0078
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Echinococcus multilocularis	geminin	0.0205	0.0381	0.0454
Brugia malayi	plexin A	0.1055	0.2257	0.2255
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0082	0.011	0.013
Brugia malayi	serine/threonine kinase 12	0.0082	0.011	0.0109
Trichomonas vaginalis	protein transport protein sec7, putative	0.0068	0.0079	0.0442
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0079	0.0079
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0057	0.0056	0.0065
Entamoeba histolytica	hypothetical protein	0.0068	0.0079	0.0154
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0057	0.0056	0.0055
Onchocerca volvulus		0.0057	0.0056	0.0289
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0079	0.0442
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0079	0.0442
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0086	0.012	1
Echinococcus granulosus	Rho GTPase activating protein 24	0.0068	0.0079	0.0093
Echinococcus granulosus	pleckstrin y domain containing family A	0.0068	0.0079	0.0093
Echinococcus granulosus	tyrosine protein kinase pr2	0.0057	0.0056	0.0065
Loa Loa (eye worm)	TK/DDR protein kinase	0.0057	0.0056	0.0056
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0076	0.0096	0.0114
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0056	0.0056
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0039	0.0016	0.0016
Echinococcus multilocularis	rac serine:threonine kinase	0.0086	0.012	0.0141
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0056	0.0056
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0068	0.0079	0.0154
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Loa Loa (eye worm)	TK/ABL protein kinase	0.0057	0.0056	0.0056
Schistosoma mansoni	protein kinase	0.0057	0.0056	0.0055
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0057	0.0056	0.0056
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0068	0.0079	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0057	0.0056	0.0055
Schistosoma mansoni	regulator of G protein signaling	0.074	0.1562	0.1561
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0068	0.0079	0.0093
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0057	0.0056	0.0065
Onchocerca volvulus		0.0057	0.0056	0.0289
Onchocerca volvulus		0.0057	0.0056	0.0289
Echinococcus granulosus	protein kinase	0.0057	0.0056	0.0065
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0068	0.0079	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0057	0.0056	0.0065
Echinococcus multilocularis	Pleckstrin y	0.0068	0.0079	0.0093
Onchocerca volvulus	Putative zinc finger protein	0.0068	0.0079	0.0412
Echinococcus multilocularis	protein kinase	0.0057	0.0056	0.0065
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0056	0.0292
Echinococcus multilocularis	regulator of G protein signaling 7	0.074	0.1562	0.1866
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0079	0.0079
Echinococcus multilocularis	cytohesin 1	0.0068	0.0079	0.0093
Brugia malayi	regulator of G-protein signaling rgs-7	0.074	0.1562	0.1561
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0057	0.0056	0.0056
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0057	0.0056	0.0065
Schistosoma mansoni	goodpasture antigen-binding protein	0.0068	0.0079	0.0078
Brugia malayi	PH domain containing protein	0.0068	0.0079	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.0294	0.1829
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0378	0.0762	0.0762
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0057	0.0056	0.0065
Echinococcus granulosus	geminin	0.0205	0.0381	0.0454
Echinococcus granulosus	semaphorin 5B	0.0378	0.0762	0.091
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0068	0.0079	0.0093
Echinococcus granulosus	twitchin	0.0135	0.0228	0.0271
Trichomonas vaginalis	centaurin gamma, putative	0.0068	0.0079	0.0442
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0057	0.0056	0.0065
Trichomonas vaginalis	protein kinase atn1, putative	0.0057	0.0056	0.0292
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0068	0.0079	0.0154
Loa Loa (eye worm)	AUR protein kinase	0.0082	0.011	0.011
Echinococcus granulosus	activated cdc42 kinase 1	0.0057	0.0056	0.0065
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Schistosoma mansoni	hypothetical protein	0.0205	0.0381	0.038
Leishmania major	folate/biopterin transporter, putative	0.0086	0.012	1
Onchocerca volvulus		0.0057	0.0056	0.0289
Brugia malayi	Cytohesin 3	0.0068	0.0079	0.0078
Schistosoma mansoni	regulator of G protein signaling	0.074	0.1562	0.1561
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0079	0.0442
Schistosoma mansoni	axis inhibition protein axin	0.074	0.1562	0.1561
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Echinococcus multilocularis	tyrosine protein kinase csk	0.0057	0.0056	0.0065
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0057	0.0056	0.0065
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0068	0.0079	0.0093
Loa Loa (eye worm)	TK/FER protein kinase	0.0057	0.0056	0.0056
Schistosoma mansoni	serine/threonine protein kinase	0.4564	1	1
Echinococcus granulosus	epidermal growth factor receptor	0.0057	0.0056	0.0065
Trichomonas vaginalis	conserved hypothetical protein	0.074	0.1562	1
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0068	0.0079	0.3651
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0056	0.0055
Loa Loa (eye worm)	cytohesin 3	0.0068	0.0079	0.0079
Echinococcus multilocularis	expressed protein	0.074	0.1562	0.1866
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0057	0.0056	0.0065
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0057	0.0056	0.0065
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0068	0.0079	0.0154
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0057	0.0056	0.0065
Echinococcus granulosus	oxysterol binding protein 1	0.0068	0.0079	0.0093
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.3498	0.7649	0.7649
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0086	0.012	0.0423
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0057	0.0056	0.0065
Echinococcus granulosus	tyrosine protein kinase csk	0.0057	0.0056	0.0065
Entamoeba histolytica	protein kinase, putative	0.0082	0.011	0.0361
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0062	0.0067	0.0078
Trypanosoma cruzi	aurora B kinase, putative	0.0082	0.011	0.8531
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0086	0.012	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0039	0.0016	0.0018
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Brugia malayi	Syntrophin-1	0.0068	0.0079	0.0078
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0086	0.012	1
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0068	0.0079	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Loa Loa (eye worm)	TK/INSR protein kinase	0.0057	0.0056	0.0056
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0165	0.0294	0.1829
Echinococcus multilocularis	tyrosine protein kinase csk	0.0057	0.0056	0.0065
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0086	0.012	0.0703
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0068	0.0079	0.0079
Brugia malayi	hypothetical protein	0.0122	0.0198	0.0197
Schistosoma mansoni	regulator of G protein signaling	0.074	0.1562	0.1561
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0057	0.0056	0.0065
Echinococcus granulosus	tyrosine protein kinase	0.0057	0.0056	0.0065
Brugia malayi	Protein kinase domain containing protein	0.0086	0.012	0.0118
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0057	0.0056	0.0065
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Trichomonas vaginalis	conserved hypothetical protein	0.074	0.1562	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0057	0.0056	0.0065
Trichomonas vaginalis	conserved hypothetical protein	0.074	0.1562	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0174	0.0314	0.0313
Trypanosoma cruzi	PH domain containing protein, putative	0.0068	0.0079	0.3651
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0086	0.012	1
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Echinococcus multilocularis	Immunoglobulin	0.0117	0.0188	0.0223
Schistosoma mansoni	tyrosine kinase	0.0057	0.0056	0.0055
Entamoeba histolytica	p21-activated kinase	0.0086	0.012	0.0423
Trichomonas vaginalis	TKL family protein kinase	0.0057	0.0056	0.0292
Echinococcus multilocularis	actin binding protein anillin	0.0068	0.0079	0.0093
Schistosoma mansoni	dynamin	0.0068	0.0079	0.0078
Entamoeba histolytica	tyrosin kinase, putative	0.0223	0.0421	0.2423
Echinococcus multilocularis	regulator of G protein signaling 3	0.074	0.1562	0.1866
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0165	0.0294	0.1829
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0068	0.0079	0.0442
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0068	0.0079	0.0154
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0165	0.0294	0.1829
Onchocerca volvulus		0.0057	0.0056	0.0289
Echinococcus multilocularis	c src tyrosine kinase	0.0057	0.0056	0.0065
Schistosoma mansoni	serine/threonine-protein kinase	0.0086	0.012	0.0118
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0086	0.012	1
Schistosoma mansoni	protein kinase	0.0076	0.0096	0.0095
Brugia malayi	hypothetical protein	0.074	0.1562	0.1561
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0076	0.0096	0.0114
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.012	0.0703
Schistosoma mansoni	oxysterol-binding protein 1	0.0068	0.0079	0.0078
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0057	0.0056	0.0065
Entamoeba histolytica	hypothetical protein	0.074	0.1562	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0057	0.0056	0.0056
Onchocerca volvulus		0.0057	0.0056	0.0289
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0117	0.0188	0.0186
Echinococcus granulosus	oxysterol binding protein 3	0.0068	0.0079	0.0093
Schistosoma mansoni	protein kinase	0.0057	0.0056	0.0055
Echinococcus multilocularis	hypothetical protein	0.0378	0.0762	0.091
Echinococcus multilocularis	tyrosine kinase	0.0057	0.0056	0.0065
Loa Loa (eye worm)	plexin A	0.1055	0.2257	0.2257
Schistosoma mansoni	protein kinase	0.0057	0.0056	0.0055
Echinococcus multilocularis	beta adrenergic receptor kinase	0.3498	0.7649	0.9141
Brugia malayi	Sema domain containing protein	0.0378	0.0762	0.0761

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.0032 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.2944 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	4.1095 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1534003

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1384119