Detailed information for compound 1384225

Basic information

Technical information
  • TDR Targets ID: 1384225
  • Name: 1-[2-ethyl-5-(3-methyl-1,2-oxazol-5-yl)phenyl ]sulfonyl-3-[(4-fluorophenyl)methyl]-1,3-diaz inane
  • MW: 443.534 | Formula: C23H26FN3O3S
  • H donors: 0 H acceptors: 3 LogP: 4.24 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1S(=O)(=O)N1CCCN(C1)Cc1ccc(cc1)F)c1onc(c1)C
  • InChi: 1S/C23H26FN3O3S/c1-3-19-7-8-20(22-13-17(2)25-30-22)14-23(19)31(28,29)27-12-4-11-26(16-27)15-18-5-9-21(24)10-6-18/h5-10,13-14H,3-4,11-12,15-16H2,1-2H3
  • InChiKey: HBIYGCQLYQHSAG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-ethyl-5-(3-methylisoxazol-5-yl)phenyl]sulfonyl-3-[(4-fluorophenyl)methyl]hexahydropyrimidine
  • 1-[2-ethyl-5-(3-methyl-5-isoxazolyl)phenyl]sulfonyl-3-[(4-fluorophenyl)methyl]hexahydropyrimidine
  • 1-[2-ethyl-5-(3-methylisoxazol-5-yl)phenyl]sulfonyl-3-(4-fluorobenzyl)hexahydropyrimidine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0055 0.0038 0.0165
Entamoeba histolytica tyrosine kinase, putative 0.0055 0.0038 0.0165
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Echinococcus granulosus plexin a4 0.1048 0.2139 0.2552
Echinococcus granulosus retinal guanylyl cyclase 2 0.0055 0.0038 0.0039
Onchocerca volvulus 0.0071 0.0071 0.0185
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Echinococcus multilocularis Ras associated and pleckstrin y 0.0071 0.0071 0.0078
Echinococcus granulosus serine/threonine protein kinase 0.009 0.0111 0.0126
Loa Loa (eye worm) hypothetical protein 0.0071 0.0071 0.0065
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0038 0.0165
Trichomonas vaginalis AGC family protein kinase 0.008 0.009 0.058
Loa Loa (eye worm) AUR protein kinase 0.008 0.009 0.0085
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Brugia malayi Regulator of G protein signaling domain containing protein 0.0772 0.1555 0.155
Loa Loa (eye worm) hypothetical protein 0.0055 0.0038 0.0032
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0055 0.0038 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Echinococcus multilocularis regulator of G protein signaling 3 0.0772 0.1555 0.1853
Loa Loa (eye worm) hypothetical protein 0.0071 0.0071 0.0065
Echinococcus granulosus beta 1 syntrophin 0.0071 0.0071 0.0078
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Echinococcus multilocularis Pleckstrin y 0.0071 0.0071 0.0078
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.0141 0.0136
Schistosoma mansoni protein kinase 0.0055 0.0038 0.003
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Schistosoma mansoni dynamin 0.0071 0.0071 0.0063
Entamoeba histolytica hypothetical protein 0.0055 0.0038 0.0165
Echinococcus granulosus axis inhibition protein axin 0.0772 0.1555 0.1853
Entamoeba histolytica hypothetical protein 0.0055 0.0038 0.0165
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0055 0.0038 0.0165
Brugia malayi Regulator of G protein signaling domain containing protein 0.0772 0.1555 0.155
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0055 0.0038 0.0032
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0055 0.0038 0.0032
Trypanosoma brucei aurora B kinase 0.008 0.009 0.7168
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0071 0.0071 0.0376
Brugia malayi Raf kinase 0.0055 0.0038 0.0032
Echinococcus granulosus tyrosine protein kinase Blk 0.0055 0.0038 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0071 0.0453
Entamoeba histolytica cysteine surface protein, putative 0.0055 0.0038 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0038 0.003
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0038 0.0165
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0155 0.0248 0.0243
Entamoeba histolytica protein kinase, putative 0.009 0.0111 0.0638
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Echinococcus granulosus tyrosine protein kinase Fyn 0.0055 0.0038 0.0039
Brugia malayi PH domain containing protein 0.0071 0.0071 0.0065
Loa Loa (eye worm) hypothetical protein 0.0071 0.0071 0.0065
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.009 0.0111 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0038 0.0032
Schistosoma mansoni oxysterol-binding protein 1 0.0071 0.0071 0.0063
Schistosoma mansoni vesicular amine transporter 0.0102 0.0136 0.0129
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.0038 0.0039
Entamoeba histolytica PH domain containing protein kinase, putative 0.009 0.0111 0.0638
Schistosoma mansoni semaphorin 5-related 0.0375 0.0714 0.0707
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0071 0.0453
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0071 0.0071 0.0376
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0164 0.0268 0.1726
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0055 0.0038 0.0039
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0055 0.0038 0.0039
Echinococcus multilocularis tyrosine protein kinase Srms 0.0055 0.0038 0.0039
Loa Loa (eye worm) oxysterol binding protein 0.0071 0.0071 0.0065
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0055 0.0038 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0071 0.0453
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0055 0.0038 0.0244
Entamoeba histolytica PH domain containing protein kinase, putative 0.009 0.0111 0.0638
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.3991 0.8366 1
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Brugia malayi hypothetical protein 0.0055 0.0038 0.0032
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.3991 0.8366 0.8365
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0071 0.0071 0.0376
Echinococcus granulosus ephrin type A receptor 4 A 0.0055 0.0038 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Trichomonas vaginalis protein tyrosine kinase, putative 0.0055 0.0038 0.0244
Loa Loa (eye worm) hypothetical protein 0.0071 0.0071 0.0065
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0038 0.0165
Schistosoma mansoni regulator of G protein signaling 0.0772 0.1555 0.1548
Entamoeba histolytica ARF GTPase activating protein, putative 0.0071 0.0071 0.0376
Schistosoma mansoni hypothetical protein 0.0055 0.0038 0.003
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0055 0.0038 0.003
Entamoeba histolytica hypothetical protein 0.0071 0.0071 0.0376
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0055 0.0038 0.0165
Toxoplasma gondii hypothetical protein 0.0071 0.0071 0.446
Schistosoma mansoni fibrocystin l 0.0164 0.0268 0.0261
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0071 0.0071 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0772 0.1555 1
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0075 0.0078 0.554
Loa Loa (eye worm) hypothetical protein 0.0375 0.0714 0.0709
Trichomonas vaginalis conserved hypothetical protein 0.0772 0.1555 1
Toxoplasma gondii phosphatidylinositol transfer protein 0.0071 0.0071 0.446
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0071 0.0071 0.0065
Schistosoma mansoni vav2 0.0071 0.0071 0.0063
Brugia malayi hypothetical protein 0.0772 0.1555 0.155
Echinococcus multilocularis neuroglian 0.0099 0.0131 0.015
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Echinococcus granulosus tyrosine protein kinase Fyn 0.0055 0.0038 0.0039
Trichomonas vaginalis AGC family protein kinase 0.008 0.009 0.058
Schistosoma mansoni hypothetical protein 0.0205 0.0354 0.0346
Onchocerca volvulus 0.0884 0.1791 1
Loa Loa (eye worm) TK protein kinase 0.0055 0.0038 0.0032
Loa Loa (eye worm) hypothetical protein 0.0772 0.1555 0.155
Trichomonas vaginalis centaurin/arf, putative 0.0071 0.0071 0.0453
Brugia malayi PH domain containing protein 0.0071 0.0071 0.0065
Brugia malayi PH domain containing protein 0.0071 0.0071 0.0065
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0055 0.0038 0.003
Loa Loa (eye worm) TK/EGFR protein kinase 0.0055 0.0038 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0038 0.0032
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0038 0.0165
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Plasmodium falciparum PH domain-containing protein, putative 0.0071 0.0071 0.446
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0071 0.0071 0.0376
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0071 0.0071 0.0078
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Entamoeba histolytica tyrosine kinase, putative 0.0055 0.0038 0.0165
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0071 0.0071 0.0078
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0055 0.0038 0.003
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.009 0.0111 0.0713
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0071 0.0071 0.446
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Schistosoma mansoni zinc finger protein 0.0071 0.0071 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Echinococcus multilocularis rac serine:threonine kinase 0.009 0.0111 0.0126
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.3991 0.8366 0.8365
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0071 0.0071 0.0376
Echinococcus multilocularis axis inhibition protein axin 0.0772 0.1555 0.1853
Echinococcus granulosus epidermal growth factor receptor 0.0055 0.0038 0.0039
Echinococcus multilocularis tyrosine protein kinase csk 0.0055 0.0038 0.0039
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0071 0.0071 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0071 0.0453
Echinococcus multilocularis Pleckstrin y 0.0071 0.0071 0.0078
Entamoeba histolytica serine/threonine kinase, putative 0.0055 0.0038 0.0165
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Echinococcus multilocularis ephrin type A receptor 4 A 0.0055 0.0038 0.0039
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0038 0.0165
Echinococcus granulosus tyrosine protein kinase csk 0.0055 0.0038 0.0039
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0038 0.0032
Entamoeba histolytica protein kinase, putative 0.0055 0.0038 0.0165
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0048 0.0042
Echinococcus multilocularis tyrosine protein kinase csk 0.0055 0.0038 0.0039
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0038 0.0165
Echinococcus multilocularis myotubularin protein 13 0.0071 0.0071 0.0078
Echinococcus granulosus G protein coupled receptor kinase 1 0.2879 0.6012 0.7185
Loa Loa (eye worm) hypothetical protein 0.0164 0.0268 0.0263
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0055 0.0038 0.003
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Echinococcus multilocularis pdz domain containing protein 0.0071 0.0071 0.0078
Echinococcus granulosus Immunoglobulin 0.0099 0.0131 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0071 0.0453
Loa Loa (eye worm) hypothetical protein 0.0772 0.1555 0.155
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0008 0.0002
Brugia malayi Immunoglobulin I-set domain containing protein 0.0155 0.0248 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0772 0.1555 1
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0038 0.0244
Loa Loa (eye worm) hypothetical protein 0.0104 0.0141 0.0136
Echinococcus multilocularis tyrosine protein kinase csk 0.0055 0.0038 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0071 0.0071 0.0078
Trypanosoma cruzi hypothetical protein 0.0071 0.0071 0.446
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0055 0.0038 0.0039
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0071 0.0071 0.0078
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0071 0.0071 0.446
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Loa Loa (eye worm) hypothetical protein 0.0099 0.0131 0.0125
Schistosoma mansoni hypothetical protein 0.0071 0.0071 0.0063
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0071 0.0071 0.0078
Echinococcus multilocularis beta 1 syntrophin 0.0071 0.0071 0.0078
Loa Loa (eye worm) TK protein kinase 0.0055 0.0038 0.0032
Entamoeba histolytica protein kinase , putative 0.008 0.009 0.0504
Brugia malayi Plekhf2 protein 0.0071 0.0071 0.0065
Echinococcus multilocularis beta adrenergic receptor kinase 0.3651 0.7647 0.914
Echinococcus multilocularis regulator of G protein signaling 3 0.0772 0.1555 0.1853
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0038 0.0165
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Brugia malayi Variant SH3 domain containing protein 0.0071 0.0071 0.0065
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0075 0.0078 0.0087
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0772 0.1555 0.1853
Brugia malayi A-kinase anchor protein 10, precursor 0.0772 0.1555 0.155
Schistosoma mansoni plexin 0.0509 0.0997 0.0991
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Entamoeba histolytica protein kinase, putative 0.0055 0.0038 0.0165
Loa Loa (eye worm) hypothetical protein 0.0509 0.0997 0.0992
Echinococcus granulosus axis inhibition protein axin 0.0772 0.1555 0.1853
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0055 0.0038 0.0165
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0071 0.0071 0.446
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.009 0.0111 1
Schistosoma mansoni goodpasture antigen-binding protein 0.0071 0.0071 0.0063
Echinococcus granulosus transcription factor collier 0.0164 0.0268 0.0314
Entamoeba histolytica protein kinase domain containing protein 0.0075 0.0078 0.0427
Entamoeba histolytica protein kinase, putative 0.0055 0.0038 0.0165
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Loa Loa (eye worm) TK protein kinase 0.0055 0.0038 0.0032
Echinococcus granulosus exocyst complex component 2 0.0164 0.0268 0.0314
Echinococcus multilocularis Immunoglobulin 0.0099 0.0131 0.015
Entamoeba histolytica hypothetical protein 0.0071 0.0071 0.0376
Brugia malayi Sema domain containing protein 0.0375 0.0714 0.0709
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0226 0.022
Echinococcus granulosus tyrosine protein kinase Src42A 0.0055 0.0038 0.0039
Echinococcus multilocularis tyrosine protein kinase pr2 0.0055 0.0038 0.0039
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.009 0.0111 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0008 0.0002
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0075 0.0078 0.0087
Loa Loa (eye worm) hypothetical protein 0.0104 0.0141 0.0136
Leishmania major protein kinase, putative 0.009 0.0111 1
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0055 0.0038 0.0165
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0038 0.0032
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0055 0.0038 0.0039
Echinococcus multilocularis tyrosine kinase 0.0055 0.0038 0.0039
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0038 0.0032
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Echinococcus multilocularis insulin receptor 0.0055 0.0038 0.0039
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Onchocerca volvulus 0.0071 0.0071 0.0185
Leishmania major hypothetical protein, conserved 0.0071 0.0071 0.446
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Echinococcus granulosus activated cdc42 kinase 1 0.0055 0.0038 0.0039
Entamoeba histolytica serine/threonine kinase, putative 0.0055 0.0038 0.0165
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0164 0.0268 0.1726
Echinococcus multilocularis natriuretic peptide receptor 1 0.0055 0.0038 0.0039
Entamoeba histolytica tyrosin kinase, putative 0.0055 0.0038 0.0165
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0055 0.0038 0.0039
Brugia malayi Probable exocyst complex component Sec5 0.0164 0.0268 0.0263
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0055 0.0038 0.0039
Trypanosoma cruzi hypothetical protein 0.0071 0.0071 0.446
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0038 0.0165
Entamoeba histolytica tyrosine kinase, putative 0.0055 0.0038 0.0165
Loa Loa (eye worm) hypothetical protein 0.0099 0.0131 0.0125
Schistosoma mansoni hypothetical protein 0.0509 0.0997 0.0991
Brugia malayi serine/threonine kinase 12 0.008 0.009 0.0085
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Loa Loa (eye worm) TK/ALK protein kinase 0.0295 0.0545 0.054
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0071 0.0071 0.0453
Toxoplasma gondii hypothetical protein 0.0071 0.0071 0.446
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Echinococcus granulosus neuroglian 0.0099 0.0131 0.015
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0038 0.0032
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.009 0.0111 1
Echinococcus multilocularis DCC interacting protein 13 beta 0.0071 0.0071 0.0078
Brugia malayi IPT/TIG domain containing protein 0.0164 0.0268 0.0263
Echinococcus multilocularis axis inhibition protein axin 0.0772 0.1555 0.1853
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0038 0.0165
Schistosoma mansoni regulator of G protein signaling 0.0772 0.1555 0.1548
Entamoeba histolytica protein kinase, putative 0.009 0.0111 0.0638
Echinococcus granulosus natriuretic peptide receptor 1 0.0055 0.0038 0.0039
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0038 0.0165
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0055 0.0038 0.0039
Entamoeba histolytica protein kinase, putative 0.0055 0.0038 0.0165
Loa Loa (eye worm) hypothetical protein 0.0772 0.1555 0.155
Brugia malayi Fibronectin type III domain containing protein 0.0104 0.0141 0.0136
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0071 0.0071 0.446
Brugia malayi hypothetical protein 0.0375 0.0714 0.0709
Loa Loa (eye worm) plexin A 0.1048 0.2139 0.2135
Schistosoma mansoni serine/threonine protein kinase 0.3651 0.7647 0.7645
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Loa Loa (eye worm) hypothetical protein 0.0375 0.0714 0.0709
Loa Loa (eye worm) protein kinase domain-containing protein 0.0055 0.0038 0.0032
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0055 0.0038 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0038 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0071 0.0453
Loa Loa (eye worm) hypothetical protein 0.0099 0.0131 0.0125
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Trichomonas vaginalis TK family protein kinase 0.0055 0.0038 0.0244
Echinococcus multilocularis regulator of G protein signaling 7 0.0772 0.1555 0.1853
Entamoeba histolytica protein kinase, putative 0.0055 0.0038 0.0165
Loa Loa (eye worm) hypothetical protein 0.0071 0.0071 0.0065
Echinococcus multilocularis aurora kinase A 0.008 0.009 0.0101
Leishmania major protein kinase, putative 0.009 0.0111 1
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Schistosoma mansoni z-protein (S1r protein) 0.0772 0.1555 0.1548
Entamoeba histolytica protein kinase, putative 0.009 0.0111 0.0638
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0075 0.0078 0.554
Brugia malayi Immunoglobulin I-set domain containing protein 0.0055 0.0038 0.0032
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0055 0.0038 0.0039
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0055 0.0038 0.0039
Entamoeba histolytica hypothetical protein 0.0164 0.0268 0.1659
Brugia malayi Uncoordinated protein 104 0.0071 0.0071 0.0065
Echinococcus multilocularis integrin linked protein kinase 0.0055 0.0038 0.0039
Schistosoma mansoni syntrophin 0.0071 0.0071 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0164 0.0268 0.1726
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0772 0.1555 0.1548
Entamoeba histolytica protein kinase domain containing protein 0.022 0.0386 0.242
Schistosoma mansoni protein kinase 0.0055 0.0038 0.003
Echinococcus granulosus Pleckstrin y 0.0071 0.0071 0.0078
Leishmania major serine/threonine-protein kinase a, putative 0.009 0.0111 1
Loa Loa (eye worm) cytohesin 3 0.0071 0.0071 0.0065
Echinococcus multilocularis expressed protein 0.0772 0.1555 0.1853
Entamoeba histolytica tyrosine kinase, putative 0.0055 0.0038 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.4763 1 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0055 0.0038 0.0032
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0013 0.0005
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0071 0.0071 0.0078
Entamoeba histolytica tyrosine kinase, putative 0.0055 0.0038 0.0165
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0055 0.0038 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0038 0.003
Brugia malayi hypothetical protein 0.0055 0.0038 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Loa Loa (eye worm) TK/DDR protein kinase 0.0055 0.0038 0.0032
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0071 0.446
Echinococcus granulosus expressed protein 0.0772 0.1555 0.1853
Brugia malayi PXA domain containing protein 0.0772 0.1555 0.155
Loa Loa (eye worm) PH domain-containing protein 0.0071 0.0071 0.0065
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0013 0.0008
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Echinococcus multilocularis geminin 0.0205 0.0354 0.0416
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0055 0.0038 0.0165
Plasmodium falciparum serine/threonine protein kinase, putative 0.008 0.009 0.7168
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0055 0.0038 0.0039
Leishmania major hypothetical protein, conserved 0.0071 0.0071 0.446
Loa Loa (eye worm) TK/Met protein kinase 0.0055 0.0038 0.0032
Entamoeba histolytica tyrosine kinase, putative 0.0055 0.0038 0.0165
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Entamoeba histolytica hypothetical protein 0.0055 0.0038 0.0165
Schistosoma mansoni dynamin 0.0071 0.0071 0.0063
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0055 0.0038 0.0039
Echinococcus multilocularis epidermal growth factor receptor 0.0055 0.0038 0.0039
Brugia malayi MH2 domain containing protein 0.0144 0.0226 0.022
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0071 0.0071 0.0063
Entamoeba histolytica PH domain containing protein kinase, putative 0.009 0.0111 0.0638
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0055 0.0038 0.0039
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0164 0.0268 0.1726
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0055 0.0038 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0071 0.0453
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Trypanosoma cruzi NIMA-related kinase, putative 0.009 0.0111 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0071 0.0065
Loa Loa (eye worm) hypothetical protein 0.0055 0.0038 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0038 0.0032
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0055 0.0038 0.0165
Entamoeba histolytica protein kinase, putative 0.008 0.009 0.0504
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0055 0.0038 0.0165
Onchocerca volvulus 0.0071 0.0071 0.0185
Plasmodium vivax serine/threonine protein kinase 6, putative 0.008 0.009 0.7168
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0038 0.0165
Echinococcus multilocularis heat shock protein 70 0.0055 0.0038 0.0039
Entamoeba histolytica protein kinase, putative 0.0055 0.0038 0.0165
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.0038 0.0039
Entamoeba histolytica p21-activated kinase 0.009 0.0111 0.0638
Schistosoma mansoni serine/threonine protein kinase 0.3651 0.7647 0.7645
Echinococcus multilocularis cytohesin 1 0.0071 0.0071 0.0078
Entamoeba histolytica tyrosine kinase, putative 0.0055 0.0038 0.0165
Trypanosoma cruzi hypothetical protein 0.0071 0.0071 0.446
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Brugia malayi PXA domain containing protein 0.0772 0.1555 0.155
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0055 0.0038 0.003
Echinococcus multilocularis protein KINase family member (kin 25) 0.0055 0.0038 0.0039
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Echinococcus multilocularis GRB2 associated binding protein 3 0.0071 0.0071 0.0078
Entamoeba histolytica protein kinase, putative 0.0055 0.0038 0.0165
Entamoeba histolytica protein kinase, putative 0.0055 0.0038 0.0165
Schistosoma mansoni ephrin receptor 0.006 0.0049 0.0041
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0038 0.0244
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Loa Loa (eye worm) hypothetical protein 0.0055 0.0038 0.0032
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0055 0.0038 0.0039
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0071 0.0071 0.0078
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0055 0.0038 0.0032
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.009 0.0111 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0055 0.0038 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Loa Loa (eye worm) AUR protein kinase 0.008 0.009 0.0085
Echinococcus multilocularis receptor type guanylyl cyclase 0.0055 0.0038 0.0039
Entamoeba histolytica hypothetical protein 0.0055 0.0038 0.0165
Entamoeba histolytica PH domain containing protein kinase, putative 0.009 0.0111 0.0638
Echinococcus multilocularis oxysterol binding protein 1 0.0071 0.0071 0.0078
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0071 0.0071 0.0078
Schistosoma mansoni hypothetical protein 0.0071 0.0071 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Schistosoma mansoni zinc finger protein 0.0071 0.0071 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Brugia malayi Receptor family ligand binding region containing protein 0.0055 0.0038 0.0032
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0071 0.0071 0.0065
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Entamoeba histolytica hypothetical protein 0.0055 0.0038 0.0165
Brugia malayi Oxysterol-binding protein 0.0071 0.0071 0.0065
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0055 0.0038 0.0039
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0071 0.0071 0.0063
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.008 0.009 0.0504
Trichomonas vaginalis AGC family protein kinase 0.008 0.009 0.058
Echinococcus granulosus semaphorin 1A 0.0375 0.0714 0.0848
Echinococcus granulosus geminin 0.0205 0.0354 0.0416
Schistosoma mansoni hypothetical protein 0.0375 0.0714 0.0707
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0038 0.0165
Trichomonas vaginalis protein kinase atn1, putative 0.0055 0.0038 0.0244
Entamoeba histolytica cell surface protease gp63, putative 0.0164 0.0268 0.1659
Loa Loa (eye worm) hypothetical protein 0.0071 0.0071 0.0065
Loa Loa (eye worm) hypothetical protein 0.0071 0.0071 0.0065
Entamoeba histolytica hypothetical protein 0.009 0.0111 0.0638
Schistosoma mansoni protein kinase 0.0055 0.0038 0.003
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Echinococcus granulosus Regulator of G protein signaling 20 0.0772 0.1555 0.1853
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Trypanosoma cruzi PH domain containing protein, putative 0.0071 0.0071 0.446
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0071 0.0071 0.0376
Schistosoma mansoni axis inhibition protein axin 0.0772 0.1555 0.1548
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Loa Loa (eye worm) TK protein kinase 0.0055 0.0038 0.0032
Schistosoma mansoni hypothetical protein 0.0071 0.0071 0.0063
Schistosoma mansoni oxysterol-binding protein 1 0.0071 0.0071 0.0063
Echinococcus granulosus tyrosine protein kinase 0.0055 0.0038 0.0039
Echinococcus multilocularis pleckstrin y domain containing family A 0.0071 0.0071 0.0078
Loa Loa (eye worm) TK/CSK protein kinase 0.0055 0.0038 0.0032
Loa Loa (eye worm) TK/FAK protein kinase 0.0055 0.0038 0.0032
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0038 0.0165
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0038 0.0165
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Echinococcus granulosus oxysterol binding protein 3 0.0071 0.0071 0.0078
Loa Loa (eye worm) hypothetical protein 0.0772 0.1555 0.155
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Loa Loa (eye worm) TK protein kinase 0.0055 0.0038 0.0032
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.008 0.009 0.0504
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0071 0.0071 0.0376
Loa Loa (eye worm) Plekhf2 protein 0.0071 0.0071 0.0065
Echinococcus multilocularis regulator of G protein signaling 7 0.0772 0.1555 0.1853
Schistosoma mansoni serine/threonine RGC 0.0055 0.0038 0.003
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.4763 1 1
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Schistosoma mansoni myotubularin-related protein 0.0071 0.0071 0.0063
Echinococcus granulosus regulator of G protein signaling 3 0.0772 0.1555 0.1853
Entamoeba histolytica protein kinase, putative 0.0055 0.0038 0.0165
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.0038 0.0039
Entamoeba histolytica tyrosine kinase, putative 0.0055 0.0038 0.0165
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0055 0.0038 0.0039
Schistosoma mansoni protein kinase 0.0055 0.0038 0.003
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0055 0.0038 0.0039
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0071 0.0071 0.0376
Echinococcus granulosus tyrosine protein kinase shark 0.0055 0.0038 0.0039
Schistosoma mansoni protein kinase 0.0075 0.0078 0.0071
Echinococcus multilocularis dynamin 1 0.0071 0.0071 0.0078
Entamoeba histolytica hypothetical protein 0.0071 0.0071 0.0376
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Echinococcus multilocularis G protein coupled receptor kinase 1 0.2879 0.6012 0.7185
Brugia malayi Pleckstrin Homology Domain 0.0071 0.0071 0.0065
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.009 0.0111 1
Entamoeba histolytica protein kinase, putative 0.009 0.0111 0.0638
Echinococcus multilocularis plexin a4 0.1048 0.2139 0.2552
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0038 0.0032
Schistosoma mansoni hypothetical protein 0.0205 0.0354 0.0346
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0055 0.0038 0.0165
Loa Loa (eye worm) hypothetical protein 0.0071 0.0071 0.0065
Brugia malayi serine/threonine-protein kinase 6 0.008 0.009 0.0085
Entamoeba histolytica tyrosine kinase, putative 0.0055 0.0038 0.0165
Entamoeba histolytica tyrosin kinase, putative 0.0055 0.0038 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0071 0.0453
Brugia malayi plexin A 0.1048 0.2139 0.2135
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0071 0.0071 0.0078
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Echinococcus granulosus regulator of G protein signaling 3 0.0772 0.1555 0.1853
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0055 0.0038 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Entamoeba histolytica hypothetical protein 0.0164 0.0268 0.1659
Echinococcus multilocularis protein kinase 0.0055 0.0038 0.0039
Loa Loa (eye worm) hypothetical protein 0.0055 0.0038 0.0032
Onchocerca volvulus 0.0375 0.0714 0.3858
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0038 0.0165
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Trypanosoma brucei protein kinase, putative 0.0075 0.0078 0.554
Trypanosoma cruzi hypothetical protein 0.0071 0.0071 0.446
Schistosoma mansoni rho gtpase activating protein 0.0071 0.0071 0.0063
Brugia malayi Oxysterol binding protein 0.0071 0.0071 0.0065
Schistosoma mansoni hypothetical protein 0.0043 0.0013 0.0005
Echinococcus multilocularis Regulator of G protein signaling 20 0.0772 0.1555 0.1853
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Echinococcus granulosus tyrosine kinase 0.0055 0.0038 0.0039
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0055 0.0038 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0038 0.003
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0013 0.0006
Loa Loa (eye worm) uncoordinated protein 104 0.0071 0.0071 0.0065
Loa Loa (eye worm) hypothetical protein 0.0104 0.0141 0.0136
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0055 0.0038 0.0165
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Entamoeba histolytica protein kinase, putative 0.0055 0.0038 0.0165
Entamoeba histolytica tyrosine kinase, putative 0.0055 0.0038 0.0165
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0038 0.0032
Brugia malayi hypothetical protein 0.0772 0.1555 0.155
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0038 0.0244
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.008 0.009 0.0504
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0055 0.0038 0.0039
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0055 0.0038 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0071 0.0453
Loa Loa (eye worm) hypothetical protein 0.0164 0.0268 0.0263
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0772 0.1555 0.155
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0071 0.0071 0.0453
Loa Loa (eye worm) RGC/RGC protein kinase 0.0055 0.0038 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0772 0.1555 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0038 0.0032
Schistosoma mansoni protein kinase 0.008 0.009 0.0083
Brugia malayi hypothetical protein 0.0104 0.0141 0.0136
Entamoeba histolytica tyrosine kinase, putative 0.0055 0.0038 0.0165
Echinococcus multilocularis exocyst complex component 2 0.0164 0.0268 0.0314
Onchocerca volvulus Protein melted homolog 0.0071 0.0071 0.0185
Loa Loa (eye worm) hypothetical protein 0.0055 0.0038 0.0032
Echinococcus granulosus regulator of G protein signaling 7 0.0772 0.1555 0.1853
Trypanosoma cruzi PH domain containing protein, putative 0.0071 0.0071 0.446
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0071 0.0071 0.0453
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0038 0.0032
Echinococcus granulosus pleckstrin y domain containing family A 0.0071 0.0071 0.0078
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Trichomonas vaginalis protein transport protein sec7, putative 0.0071 0.0071 0.0453
Echinococcus granulosus tyrosine protein kinase Fyn 0.0055 0.0038 0.0039
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0038 0.0032
Loa Loa (eye worm) TK protein kinase 0.0055 0.0038 0.0032
Brugia malayi serine/threonine protein kinase 6 0.008 0.009 0.0085
Echinococcus granulosus aurora kinase A 0.008 0.009 0.0101
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0038 0.0032
Loa Loa (eye worm) TK protein kinase 0.0055 0.0038 0.0032
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Toxoplasma gondii Oxysterol-binding protein 0.0071 0.0071 0.446
Loa Loa (eye worm) PXA domain-containing protein 0.0772 0.1555 0.155
Entamoeba histolytica PH domain containing protein kinase, putative 0.009 0.0111 0.0638
Trichomonas vaginalis centaurin/arf, putative 0.0071 0.0071 0.0453
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Entamoeba histolytica tyrosine kinase, putative 0.0055 0.0038 0.0165
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0226 0.022
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0164 0.0268 0.1726
Brugia malayi PH domain containing protein 0.0071 0.0071 0.0065
Brugia malayi PH domain containing protein 0.0071 0.0071 0.0065
Brugia malayi SRC-1 0.0055 0.0038 0.0032
Echinococcus multilocularis tyrosine protein kinase shark 0.0055 0.0038 0.0039
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0055 0.0038 0.0039
Echinococcus granulosus beta-adrenergic receptor kinase 0.3651 0.7647 0.914
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0071 0.0071 0.446
Onchocerca volvulus outspread protein homolog 0.0071 0.0071 0.0185
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0071 0.0071 0.0078
Echinococcus multilocularis oxysterol binding protein 9 0.0071 0.0071 0.0078
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0071 0.0071 0.0376
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0038 0.0032
Echinococcus granulosus activin receptor type 0.0075 0.0078 0.0087
Schistosoma mansoni hypothetical protein 0.0071 0.0071 0.0063
Brugia malayi Variant SH3 domain containing protein 0.0071 0.0071 0.0065
Entamoeba histolytica protein kinase, putative 0.009 0.0111 0.0638
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0055 0.0038 0.0039
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Entamoeba histolytica receptor protein kinase, putative 0.0055 0.0038 0.0165
Loa Loa (eye worm) RGC/RGC protein kinase 0.0055 0.0038 0.0032
Loa Loa (eye worm) TK protein kinase 0.0055 0.0038 0.0032
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0055 0.0038 0.0165
Loa Loa (eye worm) TK/INSR protein kinase 0.0055 0.0038 0.0032
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Giardia lamblia Aurora kinase 0.008 0.009 1
Schistosoma mansoni nephrin 0.0104 0.0141 0.0134
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0038 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0071 0.0453
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Echinococcus multilocularis tyrosine protein kinase csk 0.0055 0.0038 0.0039
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Brugia malayi Plexin repeat family protein 0.0884 0.1791 0.1787
Echinococcus multilocularis c src tyrosine kinase 0.0055 0.0038 0.0039
Echinococcus multilocularis tyrosine protein kinase Blk 0.0055 0.0038 0.0039
Echinococcus granulosus fibroblast growth factor receptor 4 0.0055 0.0038 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0038 0.0244
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Brugia malayi SH2 domain containing protein 0.0055 0.0038 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Loa Loa (eye worm) hypothetical protein 0.0164 0.0268 0.0263
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Schistosoma mansoni serine/threonine-protein kinase 0.009 0.0111 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0071 0.0453
Trypanosoma brucei protein kinase, putative 0.009 0.0111 1
Schistosoma mansoni protein tyrosine kinase 0.0055 0.0038 0.003
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0038 0.0032
Loa Loa (eye worm) hypothetical protein 0.0211 0.0367 0.0362
Brugia malayi C-terminal src kinase protein 1 0.0055 0.0038 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Echinococcus multilocularis Oxysterol binding protein 11 0.0071 0.0071 0.0078
Trypanosoma brucei PH domain containing protein, putative 0.0071 0.0071 0.446
Schistosoma mansoni centaurin alpha 0.0071 0.0071 0.0063
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Brugia malayi Cytohesin 3 0.0071 0.0071 0.0065
Loa Loa (eye worm) AGC/AKT protein kinase 0.009 0.0111 0.0105
Trypanosoma brucei rac serine-threonine kinase, putative 0.009 0.0111 1
Echinococcus granulosus roundabout 2 0.0104 0.0141 0.0162
Entamoeba histolytica ankyrin repeat protein 0.0055 0.0038 0.0165
Plasmodium falciparum oxysterol-binding protein, putative 0.0071 0.0071 0.446
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0048 0.0042
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Echinococcus granulosus tyrosine protein kinase ABL1 0.0055 0.0038 0.0039
Echinococcus multilocularis kinase suppressor of Ras 1 0.0055 0.0038 0.0039
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0038 0.0165
Brugia malayi Dynamin 0.0071 0.0071 0.0065
Entamoeba histolytica protein kinase, putative 0.0055 0.0038 0.0165
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0772 0.1555 0.1548
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0099 0.0131 0.0123
Entamoeba histolytica tyrosine kinase, putative 0.0055 0.0038 0.0165
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0099 0.0131 0.015
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0055 0.0038 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0071 0.0453
Echinococcus granulosus retinal guanylyl cyclase 2 0.0055 0.0038 0.0039
Entamoeba histolytica hypothetical protein 0.0071 0.0071 0.0376
Brugia malayi regulator of G-protein signaling rgs-7 0.0772 0.1555 0.155
Loa Loa (eye worm) RGC/RGC protein kinase 0.0055 0.0038 0.0032
Brugia malayi TBC domain containing protein 0.0071 0.0071 0.0065
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Plasmodium falciparum calcium-dependent protein kinase 7 0.009 0.0111 1
Echinococcus granulosus DCC interacting protein 13 beta 0.0071 0.0071 0.0078
Schistosoma mansoni hypothetical protein 0.0164 0.0268 0.0261
Toxoplasma gondii aurora kinase 0.008 0.009 0.7168
Brugia malayi Tyrosine-protein kinase PR2 0.0055 0.0038 0.0032
Echinococcus multilocularis tyrosine kinase 0.0055 0.0038 0.0039
Brugia malayi SH2 domain containing protein 0.0055 0.0038 0.0032
Brugia malayi probable spectrin beta chain 0.0071 0.0071 0.0065
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.009 0.0111 1
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Loa Loa (eye worm) TK protein kinase 0.0055 0.0038 0.0032
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0071 0.0071 0.0376
Schistosoma mansoni serine/threonine-protein kinase 0.009 0.0111 0.0103
Loa Loa (eye worm) TK/RYK protein kinase 0.0055 0.0038 0.0032
Brugia malayi PH domain containing protein 0.0071 0.0071 0.0065
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0055 0.0038 0.0032
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Brugia malayi Tyrosine-protein kinase abl-1 0.0055 0.0038 0.0032
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0071 0.0071 0.446
Toxoplasma gondii AtPH1 family protein 0.0071 0.0071 0.446
Echinococcus granulosus protein tyrosine kinase 0.0055 0.0038 0.0039
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0071 0.0071 0.0078
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0071 0.0071 0.446
Echinococcus granulosus cytohesin 1 0.0071 0.0071 0.0078
Entamoeba histolytica ankyrin repeat protein 0.0055 0.0038 0.0165
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0038 0.0165
Entamoeba histolytica protein kinase, putative 0.0055 0.0038 0.0165
Echinococcus granulosus myotubularin protein 13 0.0071 0.0071 0.0078
Loa Loa (eye worm) sema domain-containing protein 0.0375 0.0714 0.0709
Schistosoma mansoni protein kinase 0.0055 0.0038 0.003
Entamoeba histolytica hypothetical protein 0.0071 0.0071 0.0376
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0038 0.0244
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Echinococcus granulosus tyrosine kinase 0.0055 0.0038 0.0039
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0071 0.0071 0.0376
Brugia malayi Dynamin 0.0071 0.0071 0.0065
Entamoeba histolytica hypothetical protein 0.0055 0.0038 0.0165
Echinococcus granulosus Pleckstrin y 0.0071 0.0071 0.0078
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0055 0.0038 0.0039
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0055 0.0038 0.0039
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0055 0.0038 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0164 0.0268 0.1726
Schistosoma mansoni protein kinase 0.0055 0.0038 0.003
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Loa Loa (eye worm) hypothetical protein 0.0375 0.0714 0.0709
Trypanosoma cruzi NIMA-related kinase, putative 0.009 0.0111 1
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0038 0.0244
Echinococcus granulosus raf serine:threonine protein kinase 0.0055 0.0038 0.0039
Brugia malayi regulator of G-protein signaling egl-10 0.0772 0.1555 0.155
Loa Loa (eye worm) hypothetical protein 0.0055 0.0038 0.0032
Entamoeba histolytica serine/threonine kinase, putative 0.0055 0.0038 0.0165
Entamoeba histolytica hypothetical protein, conserved 0.0055 0.0038 0.0165
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0055 0.0038 0.0032
Loa Loa (eye worm) hypothetical protein 0.0099 0.0131 0.0125
Schistosoma mansoni cell adhesion molecule 0.0104 0.0141 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0071 0.0453
Loa Loa (eye worm) hypothetical protein 0.006 0.0048 0.0042
Plasmodium falciparum protein kinase, putative 0.0075 0.0078 0.554
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0055 0.0038 0.003
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0055 0.0038 0.0039
Entamoeba histolytica hypothetical protein 0.0164 0.0268 0.1659
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0071 0.0071 0.0078
Entamoeba histolytica hypothetical protein 0.0772 0.1555 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0772 0.1555 0.1548
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0055 0.0038 0.0039
Loa Loa (eye worm) syntrophin-1 0.0071 0.0071 0.0065
Entamoeba histolytica protein kinase domain containing protein 0.008 0.009 0.0504
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0038 0.0165
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0055 0.0038 0.0039
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0055 0.0038 0.0039
Echinococcus multilocularis regulator of G protein signaling 0.0772 0.1555 0.1853
Schistosoma mansoni hypothetical protein 0.0164 0.0268 0.0261
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Echinococcus multilocularis transfer RNA-Thr 0.0055 0.0038 0.0039
Echinococcus multilocularis hypothetical protein 0.0375 0.0714 0.0848
Schistosoma mansoni axis inhibition protein axin 0.0772 0.1555 0.1548
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0055 0.0038 0.0032
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0164 0.0268 0.1726
Entamoeba histolytica protein kinase, putative 0.0055 0.0038 0.0165
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0075 0.0078 0.554
Leishmania major protein kinase, putative 0.0075 0.0078 0.554
Loa Loa (eye worm) serine/threonine protein kinase 0.0055 0.0038 0.0032
Brugia malayi Sema domain containing protein 0.0375 0.0714 0.0709
Loa Loa (eye worm) hypothetical protein 0.0071 0.0071 0.0065
Echinococcus granulosus tyrosine protein kinase Lyn 0.0075 0.0078 0.0087
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0071 0.0071 0.0078
Echinococcus granulosus oxysterol binding protein 1 0.0071 0.0071 0.0078
Echinococcus granulosus c src tyrosine kinase 0.0055 0.0038 0.0039
Entamoeba histolytica hypothetical protein 0.0772 0.1555 1
Trypanosoma cruzi PH domain containing protein, putative 0.0071 0.0071 0.446
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0071 0.0453
Brugia malayi protein-tyrosine kinase 0.0055 0.0038 0.0032
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0055 0.0038 0.0244
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Echinococcus multilocularis calcium dependent secretion activator 1 0.0071 0.0071 0.0078
Entamoeba histolytica hypothetical protein 0.0055 0.0038 0.0165
Schistosoma mansoni protein kinase 0.0075 0.0078 0.0071
Echinococcus granulosus retinal guanylyl cyclase 2 0.0055 0.0038 0.0039
Loa Loa (eye worm) hypothetical protein 0.0055 0.0038 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Loa Loa (eye worm) hypothetical protein 0.0055 0.0038 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0038 0.0032
Schistosoma mansoni growth factor receptor-bound protein 0.0071 0.0071 0.0063
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0071 0.0071 0.0376
Loa Loa (eye worm) TK protein kinase 0.0055 0.0038 0.0032
Trypanosoma cruzi aurora B kinase, putative 0.008 0.009 0.7168
Loa Loa (eye worm) hypothetical protein 0.0071 0.0071 0.0065
Echinococcus granulosus Oxysterol binding protein 11 0.0071 0.0071 0.0078
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0071 0.0071 0.0376
Brugia malayi hypothetical protein 0.0055 0.0038 0.0032
Trichomonas vaginalis centaurin beta, putative 0.0071 0.0071 0.0453
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0071 0.0071 0.0065
Trichomonas vaginalis kinesin light chain, putative 0.0071 0.0071 0.0453
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.009 0.0111 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0055 0.0038 0.0032
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0055 0.0038 0.0165
Trypanosoma cruzi hypothetical protein 0.0071 0.0071 0.446
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.009 0.0111 1
Entamoeba histolytica hypothetical protein, conserved 0.0071 0.0071 0.0376
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0099 0.0131 0.0123
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Echinococcus multilocularis Immunoglobulin 0.0099 0.0131 0.015
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0055 0.0038 0.0165
Onchocerca volvulus 0.0071 0.0071 0.0185
Echinococcus multilocularis Pleckstrin y 0.0071 0.0071 0.0078
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Loa Loa (eye worm) hypothetical protein 0.0055 0.0038 0.0032
Trichomonas vaginalis hypothetical protein 0.0071 0.0071 0.0453
Loa Loa (eye worm) hypothetical protein 0.0071 0.0071 0.0065
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Loa Loa (eye worm) hypothetical protein 0.0071 0.0071 0.0065
Brugia malayi Furin-like cysteine rich region family protein 0.0055 0.0038 0.0032
Echinococcus granulosus GRB2 associated binding protein 3 0.0071 0.0071 0.0078
Entamoeba histolytica protein kinase, putative 0.0055 0.0038 0.0165
Entamoeba histolytica hypothetical protein 0.0055 0.0038 0.0165
Entamoeba histolytica hypothetical protein 0.0055 0.0038 0.0165
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0038 0.0032
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0071 0.0453
Echinococcus multilocularis transcription factor collier 0.0164 0.0268 0.0314
Loa Loa (eye worm) RGS-3 protein 0.0772 0.1555 0.155
Echinococcus multilocularis tyrosine protein kinase Abl 0.0055 0.0038 0.0039
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0071 0.0071 0.0376
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.009 0.0111 1
Plasmodium vivax PH domain containing protein 0.0071 0.0071 0.446
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0071 0.0453
Loa Loa (eye worm) hypothetical protein 0.0884 0.1791 0.1787
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0038 0.0244
Loa Loa (eye worm) hypothetical protein 0.0099 0.0131 0.0125
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0013 0.0006
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0038 0.0165
Loa Loa (eye worm) sema domain-containing protein 0.0375 0.0714 0.0709
Echinococcus granulosus tyrosine protein kinase csk 0.0055 0.0038 0.0039
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Brugia malayi PH domain containing protein 0.0071 0.0071 0.0065
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Entamoeba histolytica PH domain containing protein kinase, putative 0.009 0.0111 0.0638
Entamoeba histolytica protein kinase, putative 0.0055 0.0038 0.0165
Schistosoma mansoni tyrosine protein kinase 0.0055 0.0038 0.003
Entamoeba histolytica protein kinase, putative 0.0055 0.0038 0.0165
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0071 0.0071 0.0185
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0099 0.0131 0.015
Loa Loa (eye worm) hypothetical protein 0.0375 0.0714 0.0709
Trypanosoma cruzi rac serine-threonine kinase, putative 0.009 0.0111 1
Trichomonas vaginalis protein transport protein sec7, putative 0.0071 0.0071 0.0453
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0071 0.0071 0.0065
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Echinococcus granulosus Pleckstrin y 0.0071 0.0071 0.0078
Loa Loa (eye worm) TK/ABL protein kinase 0.0055 0.0038 0.0032
Echinococcus granulosus calcium dependent secretion activator 1 0.0071 0.0071 0.0078
Echinococcus granulosus tyrosine protein kinase pr2 0.0055 0.0038 0.0039
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Trypanosoma cruzi PH domain containing protein, putative 0.0071 0.0071 0.446
Echinococcus granulosus tyrosine protein kinase Srms 0.0055 0.0038 0.0039
Loa Loa (eye worm) hypothetical protein 0.0055 0.0038 0.0032
Brugia malayi Guanylyl cyclase protein 23 0.0055 0.0038 0.0032
Echinococcus multilocularis protein tyrosine kinase 0.0055 0.0038 0.0039
Leishmania major folate/biopterin transporter, putative 0.009 0.0111 1
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.009 0.0111 1
Echinococcus granulosus oxysterol binding protein 9 0.0071 0.0071 0.0078
Schistosoma mansoni hypothetical protein 0.0071 0.0071 0.0063
Schistosoma mansoni goodpasture antigen-binding protein 0.0071 0.0071 0.0063
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0071 0.0071 0.0453
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Schistosoma mansoni plexin 0.0884 0.1791 0.1785
Loa Loa (eye worm) hypothetical protein 0.0071 0.0071 0.0065
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0164 0.0268 0.1726
Onchocerca volvulus 0.0071 0.0071 0.0185
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0055 0.0038 0.0244
Entamoeba histolytica hypothetical protein 0.0164 0.0268 0.1659
Echinococcus granulosus dynamin 1 0.0071 0.0071 0.0078
Trypanosoma cruzi serine/threonine protein kinase, putative 0.009 0.0111 1
Loa Loa (eye worm) TK/ACK protein kinase 0.0055 0.0038 0.0032
Brugia malayi integrin-linked kinase 0.0055 0.0038 0.0032
Echinococcus multilocularis roundabout 2 0.0104 0.0141 0.0162
Entamoeba histolytica hypothetical protein 0.009 0.0111 0.0638
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0772 0.1555 0.1853
Loa Loa (eye worm) hypothetical protein 0.0055 0.0038 0.0032
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Brugia malayi bone morphogenetic protein type 1 receptor 0.0055 0.0038 0.0032
Entamoeba histolytica protein kinase, putative 0.009 0.0111 0.0638
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0071 0.0071 0.0078
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0055 0.0038 0.0165
Leishmania major protein kinase, putative 0.008 0.009 0.7168
Trichomonas vaginalis conserved hypothetical protein 0.0164 0.0268 0.1726
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0071 0.0071 0.0078
Brugia malayi Protein kinase domain containing protein 0.0295 0.0545 0.054
Entamoeba histolytica hypothetical protein 0.0055 0.0038 0.0165
Brugia malayi hypothetical protein 0.0043 0.0013 0.0007
Brugia malayi Protein kinase domain containing protein 0.009 0.0111 0.0105
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0055 0.0038 0.0032
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0164 0.0268 0.1726
Echinococcus granulosus tyrosine protein kinase csk 0.0055 0.0038 0.0039
Loa Loa (eye worm) hypothetical protein 0.0071 0.0071 0.0065
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.009 0.0111 0.0713
Loa Loa (eye worm) rho-GTPase-activating 0.0071 0.0071 0.0065
Brugia malayi Syntrophin-1 0.0071 0.0071 0.0065
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0013 0.0008
Echinococcus multilocularis Rho GTPase activating protein 24 0.0071 0.0071 0.0078
Brugia malayi ephrin receptor 1 precursor 0.0055 0.0038 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Entamoeba histolytica tyrosin kinase, putative 0.022 0.0386 0.242
Trichomonas vaginalis STE family protein kinase 0.0055 0.0038 0.0244
Loa Loa (eye worm) AUR protein kinase 0.008 0.009 0.0085
Entamoeba histolytica protein kinase, putative 0.0055 0.0038 0.0165
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Trypanosoma cruzi hypothetical protein 0.0071 0.0071 0.446
Schistosoma mansoni ephrin receptor 0.0055 0.0038 0.003
Trypanosoma cruzi rac serine-threonine kinase, putative 0.009 0.0111 1
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Schistosoma mansoni serine/threonine protein kinase 0.008 0.009 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Echinococcus granulosus insulin receptor 0.0055 0.0038 0.0039
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0071 0.0071 0.0453
Schistosoma mansoni protein kinase 0.0055 0.0038 0.003
Brugia malayi hypothetical protein 0.0375 0.0714 0.0709
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0071 0.0071 0.0185
Brugia malayi PH domain containing protein 0.0071 0.0071 0.0065
Entamoeba histolytica tyrosine kinase, putative 0.0055 0.0038 0.0165
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Schistosoma mansoni regulator of G protein signaling 0.0772 0.1555 0.1548
Echinococcus multilocularis tyrosine protein kinase HCK 0.0055 0.0038 0.0039
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0071 0.0071 0.0065
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0055 0.0038 0.0032
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0055 0.0038 0.0032
Echinococcus multilocularis activated cdc42 kinase 1 0.0055 0.0038 0.0039
Schistosoma mansoni protein kinase 0.0075 0.0078 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0164 0.0268 0.1726
Onchocerca volvulus 0.0071 0.0071 0.0185
Entamoeba histolytica PH domain containing protein 0.0071 0.0071 0.0376
Loa Loa (eye worm) TK/EPH protein kinase 0.0055 0.0038 0.0032
Loa Loa (eye worm) hypothetical protein 0.0375 0.0714 0.0709
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0055 0.0038 0.0039
Loa Loa (eye worm) hypothetical protein 0.0071 0.0071 0.0065
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0071 0.0071 0.0453
Loa Loa (eye worm) hypothetical protein 0.0071 0.0071 0.0065
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.006 0.0049 0.0051
Entamoeba histolytica tyrosin kinase, putative 0.0055 0.0038 0.0165
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0071 0.0071 0.446
Entamoeba histolytica serine/threonine kinase, putative 0.0055 0.0038 0.0165
Entamoeba histolytica protein kinase, putative 0.009 0.0111 0.0638
Brugia malayi PH domain containing protein 0.0071 0.0071 0.0065
Schistosoma mansoni hypothetical protein 0.0375 0.0714 0.0707
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0055 0.0038 0.0244
Echinococcus granulosus pdz domain containing protein 0.0071 0.0071 0.0078
Schistosoma mansoni regulator of G protein signaling 0.0772 0.1555 0.1548
Trichomonas vaginalis AGC family protein kinase 0.008 0.009 0.058
Loa Loa (eye worm) TK/ROR protein kinase 0.0055 0.0038 0.0032
Echinococcus granulosus regulator of G protein signaling 7 0.0772 0.1555 0.1853
Echinococcus granulosus serine:threonine protein kinase 12 B 0.008 0.009 0.0101
Echinococcus multilocularis tyrosine protein kinase 0.0055 0.0038 0.0039
Echinococcus multilocularis activin receptor type 0.0075 0.0078 0.0087
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.009 0.0111 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.3991 0.8366 0.8365
Schistosoma mansoni regulator of G protein signaling 0.0772 0.1555 0.1548
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Entamoeba histolytica serine/threonine kinase, putative 0.0055 0.0038 0.0165
Entamoeba histolytica protein kinase, putative 0.008 0.009 0.0504
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0772 0.1555 1
Echinococcus multilocularis protein kinase 0.0055 0.0038 0.0039
Entamoeba histolytica tyrosine kinase, putative 0.0055 0.0038 0.0165
Loa Loa (eye worm) hypothetical protein 0.0071 0.0071 0.0065
Echinococcus granulosus twitchin 0.0118 0.0171 0.0198
Entamoeba histolytica protein kinase, putative 0.0055 0.0038 0.0165
Echinococcus multilocularis oxysterol binding protein 3 0.0071 0.0071 0.0078
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Loa Loa (eye worm) hypothetical protein 0.0772 0.1555 0.155
Entamoeba histolytica PH domain containing protein 0.0071 0.0071 0.0376
Brugia malayi Cadps2 protein 0.0071 0.0071 0.0065
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.3651 0.7647 0.7645
Entamoeba histolytica receptor protein kinase, putative 0.0055 0.0038 0.0165
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0071 0.0071 0.0063
Trichomonas vaginalis alpha chimerin, putative 0.0071 0.0071 0.0453
Echinococcus granulosus integrin linked protein kinase 0.0055 0.0038 0.0039
Loa Loa (eye worm) hypothetical protein 0.0375 0.0714 0.0709
Toxoplasma gondii protein kinase domain-containing protein 0.009 0.0111 1
Echinococcus multilocularis FL cytokine receptor 0.0055 0.0038 0.0039
Trichomonas vaginalis centaurin gamma, putative 0.0071 0.0071 0.0453
Echinococcus granulosus Rho GTPase activating protein 24 0.0071 0.0071 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0071 0.0453
Brugia malayi hypothetical protein 0.0071 0.0071 0.0065
Entamoeba histolytica tyrosine kinase, putative 0.0055 0.0038 0.0165
Trichomonas vaginalis centaurin alpha, putative 0.0071 0.0071 0.0453
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0071 0.0071 0.0065
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0075 0.0078 0.554
Entamoeba histolytica hypothetical protein 0.0055 0.0038 0.0165
Loa Loa (eye worm) hypothetical protein 0.0772 0.1555 0.155
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.009 0.0111 1
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.009 0.0111 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.0038 0.0039
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0055 0.0038 0.0039
Echinococcus granulosus protein kinase 0.0055 0.0038 0.0039
Echinococcus granulosus tyrosine kinase 0.0055 0.0038 0.0039
Loa Loa (eye worm) SRC-1 0.0055 0.0038 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0038 0.0032
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0048 0.0042
Trypanosoma cruzi hypothetical protein 0.0071 0.0071 0.446
Brugia malayi MAX-1A 0.0071 0.0071 0.0065
Echinococcus multilocularis G protein coupled receptor kinase 6 0.3991 0.8366 1
Echinococcus granulosus kinase suppressor of Ras 1 0.0055 0.0038 0.0039
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0055 0.0038 0.0039
Entamoeba histolytica PH domain containing protein 0.0071 0.0071 0.0376
Entamoeba histolytica protein kinase, putative 0.0055 0.0038 0.0165
Echinococcus granulosus semaphorin 5B 0.0375 0.0714 0.0848
Echinococcus granulosus insulin growth factor 1 receptor beta 0.006 0.0049 0.0051
Trichomonas vaginalis AGC family protein kinase 0.009 0.0111 0.0713
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0038 0.0244
Onchocerca volvulus 0.0071 0.0071 0.0185
Onchocerca volvulus Putative zinc finger protein 0.0071 0.0071 0.0185
Echinococcus multilocularis epidermal growth factor receptor 0.0055 0.0038 0.0039
Schistosoma mansoni protein kinase 0.0055 0.0038 0.003
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Echinococcus granulosus receptor type guanylyl cyclase 0.0055 0.0038 0.0039
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.008 0.009 0.0101
Loa Loa (eye worm) hypothetical protein 0.0099 0.0131 0.0125
Schistosoma mansoni tyrosine kinase 0.0055 0.0038 0.003
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0055 0.0038 0.0039
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.0038 0.0032
Brugia malayi DNA-binding protein LAG-1 0.0164 0.0268 0.0263
Entamoeba histolytica hypothetical protein 0.0772 0.1555 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0055 0.0038 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0772 0.1555 1
Trypanosoma cruzi Protein kinase B 0.009 0.0111 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0055 0.0038 0.0165
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0071 0.0071 0.0063
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0038 0.003
Loa Loa (eye worm) hypothetical protein 0.0164 0.0268 0.0263
Entamoeba histolytica tyrosine kinase, putative 0.0055 0.0038 0.0165
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0071 0.0071 0.446
Loa Loa (eye worm) hypothetical protein 0.0071 0.0071 0.0065
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Entamoeba histolytica serine/threonine kinase, putative 0.0055 0.0038 0.0165
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0055 0.0038 0.0039
Echinococcus multilocularis semaphorin 5B 0.0375 0.0714 0.0848
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0055 0.0038 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0164 0.0268 0.1726
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0055 0.0038 0.0039
Echinococcus multilocularis actin binding protein anillin 0.0071 0.0071 0.0078
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0071 0.0071 0.0376
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0772 0.1555 1
Trichomonas vaginalis TKL family protein kinase 0.0055 0.0038 0.0244
Echinococcus granulosus activated cdc42 kinase 1 0.0055 0.0038 0.0039
Echinococcus granulosus defective proboscis extension response 0.0099 0.0131 0.015
Echinococcus multilocularis raf serine:threonine protein kinase 0.0055 0.0038 0.0039
Echinococcus granulosus epidermal growth factor receptor 0.0055 0.0038 0.0039
Brugia malayi Protein kinase domain containing protein 0.0055 0.0038 0.0032
Echinococcus granulosus tyrosine protein kinase HCK 0.0055 0.0038 0.0039
Loa Loa (eye worm) hypothetical protein 0.0071 0.0071 0.0065

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8199 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.2 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: Hit Validation in HepG2 Cells using COP promoter. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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