Detailed information for compound 1384557

Basic information

Technical information
  • TDR Targets ID: 1384557
  • Name: N-[2-(tert-butylamino)-1-(2-fluorophenyl)-2-o xoethyl]-N-(furan-2-ylmethyl)thiadiazole-4-ca rboxamide
  • MW: 416.469 | Formula: C20H21FN4O3S
  • H donors: 1 H acceptors: 4 LogP: 2.95 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N(C(c1ccccc1F)C(=O)NC(C)(C)C)Cc1ccco1)c1nnsc1
  • InChi: 1S/C20H21FN4O3S/c1-20(2,3)22-18(26)17(14-8-4-5-9-15(14)21)25(11-13-7-6-10-28-13)19(27)16-12-29-24-23-16/h4-10,12,17H,11H2,1-3H3,(H,22,26)
  • InChiKey: FDKBMZMATWFSBO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(tert-butylamino)-1-(2-fluorophenyl)-2-oxo-ethyl]-N-(2-furylmethyl)thiadiazole-4-carboxamide
  • N-[2-(tert-butylamino)-1-(2-fluorophenyl)-2-oxoethyl]-N-(2-furylmethyl)-4-thiadiazolecarboxamide
  • N-[2-(tert-butylamino)-1-(2-fluorophenyl)-2-keto-ethyl]-N-(2-furylmethyl)thiadiazole-4-carboxamide
  • N-[2-(tert-butylamino)-1-(2-fluorophenyl)-2-oxo-ethyl]-N-(furan-2-ylmethyl)-1,2,3-thiadiazole-4-carboxamide
  • ASN 06570089
  • MLS000074041
  • [1,2,3]Thiadiazole-4-carboxylic acid [tert-butylcarbamoyl-(2-fluoro-phenyl)-methyl]-furan-2-ylmethyl-amide
  • SMR000006883

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0044 0.001 0.001
Trypanosoma cruzi hypothetical protein 0.0067 0.0061 0.5662
Trypanosoma cruzi PH domain containing protein, putative 0.0067 0.0061 0.5662
Entamoeba histolytica hypothetical protein 0.0067 0.0061 0.0333
Trichomonas vaginalis AGC family protein kinase 0.0076 0.0081 0.0472
Schistosoma mansoni myotubularin-related protein 0.0067 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0067 0.0061 0.0061
Trichomonas vaginalis centaurin gamma, putative 0.0067 0.0061 0.0343
Trypanosoma cruzi Protein kinase B 0.0085 0.0102 1
Trichomonas vaginalis AGC family protein kinase 0.0076 0.0081 0.0472
Entamoeba histolytica PH domain containing protein kinase, putative 0.0085 0.0102 0.0596
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Trypanosoma cruzi PH domain containing protein, putative 0.0067 0.0061 0.5662
Onchocerca volvulus 0.0067 0.0061 0.035
Echinococcus granulosus retinal guanylyl cyclase 2 0.0044 0.001 0.0012
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0085 0.0102 1
Brugia malayi hypothetical protein 0.0068 0.0065 0.0065
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0067 0.0061 0.0073
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0067 0.0061 0.0061
Echinococcus granulosus tyrosine protein kinase 0.0044 0.001 0.0012
Echinococcus granulosus epidermal growth factor receptor 0.0044 0.001 0.0012
Trichomonas vaginalis centaurin alpha, putative 0.0067 0.0061 0.0343
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0044 0.001 0.0012
Echinococcus multilocularis kinase suppressor of Ras 1 0.0044 0.001 0.0012
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Schistosoma mansoni vesicular amine transporter 0.0066 0.0059 0.0059
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0067 0.0061 0.0333
Brugia malayi Cadps2 protein 0.0067 0.0061 0.0061
Echinococcus multilocularis regulator of G protein signaling 7 0.0731 0.1547 0.185
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Schistosoma mansoni protein kinase 0.0076 0.0081 0.0081
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.001 0.001
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0067 0.0061 0.0073
Brugia malayi Protein kinase domain containing protein 0.0311 0.0607 0.0607
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0067 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0067 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0067 0.0061 0.0061
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0076 0.0081 0.0463
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0044 0.001 0.001
Brugia malayi Cytohesin 3 0.0067 0.0061 0.0061
Schistosoma mansoni growth factor receptor-bound protein 0.0067 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0305 0.0594 0.0594
Trichomonas vaginalis conserved hypothetical protein 0.0731 0.1547 1
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.001 0.001
Entamoeba histolytica protein kinase, putative 0.0076 0.0081 0.0463
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0009
Schistosoma mansoni fibrocystin l 0.0134 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0134 0.021 0.021
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Brugia malayi beta-lactamase family protein 0.0043 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0067 0.0061 0.0061
Echinococcus granulosus myotubularin protein 13 0.0067 0.0061 0.0073
Trypanosoma brucei Flagellum attachment zone protein 20 0.0044 0.001 0.0158
Echinococcus multilocularis epidermal growth factor receptor 0.0044 0.001 0.0012
Toxoplasma gondii AtPH1 family protein 0.0067 0.0061 0.5662
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.021 0.1311
Echinococcus multilocularis expressed protein 0.0731 0.1547 0.185
Brugia malayi PXA domain containing protein 0.0731 0.1547 0.1547
Loa Loa (eye worm) TK/ABL protein kinase 0.0044 0.001 0.001
Schistosoma mansoni plexin 0.0717 0.1516 0.1516
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0044 0.001 0.0012
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Echinococcus multilocularis regulator of G protein signaling 3 0.0731 0.1547 0.185
Echinococcus granulosus tyrosine kinase 0.0044 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0044 0.001 0.001
Loa Loa (eye worm) TK/DDR protein kinase 0.0044 0.001 0.001
Onchocerca volvulus 0.0044 0.001 0.001
Entamoeba histolytica protein kinase, putative 0.0085 0.0102 0.0596
Entamoeba histolytica protein kinase, putative 0.0085 0.0102 0.0596
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0035 0.0042
Loa Loa (eye worm) hypothetical protein 0.0067 0.0061 0.0061
Onchocerca volvulus 0.0067 0.0061 0.035
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0000059075 0.0000059075
Schistosoma mansoni rho gtpase activating protein 0.0067 0.0061 0.0061
Plasmodium vivax protein kinase, putative 0.0044 0.001 0.0158
Loa Loa (eye worm) hypothetical protein 0.0134 0.021 0.021
Loa Loa (eye worm) TK/Met protein kinase 0.0044 0.001 0.001
Echinococcus multilocularis tyrosine protein kinase shark 0.0044 0.001 0.0012
Trypanosoma cruzi hypothetical protein 0.0067 0.0061 0.5662
Loa Loa (eye worm) hypothetical protein 0.0067 0.0061 0.0061
Echinococcus granulosus kinase suppressor of Ras 1 0.0044 0.001 0.0012
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0085 0.0102 1
Loa Loa (eye worm) sema domain-containing protein 0.0305 0.0594 0.0594
Trichomonas vaginalis AGC family protein kinase 0.0044 0.001 0.001
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0305 0.0594 0.0594
Trichomonas vaginalis CAMK family protein kinase 0.0044 0.001 0.001
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Echinococcus multilocularis tyrosine protein kinase csk 0.0044 0.001 0.0012
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Trypanosoma cruzi hypothetical protein 0.0067 0.0061 0.5662
Echinococcus multilocularis Pleckstrin y 0.0067 0.0061 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0061 0.0343
Brugia malayi PH domain containing protein 0.0067 0.0061 0.0061
Echinococcus granulosus fibroblast growth factor receptor 4 0.0044 0.001 0.0012
Echinococcus multilocularis tyrosine protein kinase csk 0.0044 0.001 0.0012
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0044 0.001 0.0012
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0067 0.0061 0.0333
Brugia malayi Tyrosine-protein kinase abl-1 0.0044 0.001 0.001
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0067 0.0061 0.0061
Leishmania major protein kinase, putative 0.0044 0.001 0.0158
Loa Loa (eye worm) TK protein kinase 0.0044 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.001 0.001
Echinococcus multilocularis heat shock protein 70 0.0044 0.001 0.0012
Echinococcus multilocularis epidermal growth factor receptor 0.0044 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0067 0.0061 0.0061
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0076 0.0081 0.7798
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0044 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0067 0.0061 0.0061
Echinococcus granulosus tyrosine protein kinase Fyn 0.0044 0.001 0.0012
Echinococcus multilocularis Pleckstrin y 0.0067 0.0061 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Onchocerca volvulus 0.0044 0.001 0.001
Onchocerca volvulus 0.0044 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0061 0.0343
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0061 0.0343
Leishmania major protein kinase, putative 0.0085 0.0102 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0068 0.0065 0.0065
Schistosoma mansoni dynamin 0.0067 0.0061 0.0061
Entamoeba histolytica hypothetical protein 0.0134 0.021 0.1303
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0085 0.0102 1
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Echinococcus granulosus oxysterol binding protein 3 0.0067 0.0061 0.0073
Entamoeba histolytica PH domain containing protein kinase, putative 0.0085 0.0102 0.0596
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.001 0.001
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0067 0.0061 0.5592
Schistosoma mansoni regulator of G protein signaling 0.0731 0.1547 0.1547
Echinococcus granulosus tyrosine protein kinase Blk 0.0044 0.001 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0061 0.0343
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0035 0.0042
Loa Loa (eye worm) hypothetical protein 0.0044 0.001 0.001
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Loa Loa (eye worm) oxysterol binding protein 0.0067 0.0061 0.0061
Brugia malayi hypothetical protein 0.0731 0.1547 0.1547
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Brugia malayi SH2 domain containing protein 0.0044 0.001 0.001
Loa Loa (eye worm) RGC/RGC protein kinase 0.0044 0.001 0.001
Brugia malayi Variant SH3 domain containing protein 0.0067 0.0061 0.0061
Trichomonas vaginalis centaurin/arf, putative 0.0067 0.0061 0.0343
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0085 0.0102 1
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Echinococcus granulosus tyrosine protein kinase csk 0.0044 0.001 0.0012
Entamoeba histolytica hypothetical protein 0.0067 0.0061 0.0333
Echinococcus multilocularis roundabout 2 0.0068 0.0065 0.0077
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Onchocerca volvulus 0.0067 0.0061 0.035
Loa Loa (eye worm) TK/ACK protein kinase 0.0044 0.001 0.001
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0044 0.001 0.001
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Brugia malayi Probable exocyst complex component Sec5 0.0134 0.021 0.021
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0044 0.001 0.001
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Echinococcus granulosus neuroglian 0.0063 0.0054 0.0064
Echinococcus multilocularis rac serine:threonine kinase 0.0085 0.0102 0.0122
Echinococcus multilocularis tyrosine kinase 0.0044 0.001 0.0012
Entamoeba histolytica protein kinase domain containing protein 0.0178 0.0309 0.1946
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0731 0.1547 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0009
Onchocerca volvulus 0.0044 0.001 0.001
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Entamoeba histolytica protein kinase, putative 0.0076 0.0081 0.0463
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0044 0.001 0.0012
Echinococcus granulosus tyrosine protein kinase csk 0.0044 0.001 0.0012
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0085 0.0102 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0067 0.0061 0.0343
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0044 0.001 0.0012
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.001 0.001
Echinococcus multilocularis oxysterol binding protein 1 0.0067 0.0061 0.0073
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Loa Loa (eye worm) TK/CSK protein kinase 0.0044 0.001 0.001
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0063 0.0054 0.0054
Trypanosoma cruzi hypothetical protein 0.0067 0.0061 0.5662
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0044 0.001 0.0012
Trypanosoma cruzi protein kinase, putative 0.0044 0.001 0.0158
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0067 0.0061 0.0061
Echinococcus granulosus twitchin 0.0082 0.0094 0.0112
Echinococcus multilocularis actin binding protein anillin 0.0067 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.0067 0.0061 0.0061
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Trypanosoma brucei PH domain containing protein, putative 0.0067 0.0061 0.5662
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0067 0.0061 0.0333
Trichomonas vaginalis centaurin beta, putative 0.0067 0.0061 0.0343
Brugia malayi IPT/TIG domain containing protein 0.0134 0.021 0.021
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0044 0.001 0.0012
Echinococcus granulosus beta-adrenergic receptor kinase 0.3454 0.7645 0.914
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0044 0.001 0.001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.0067 0.0061 0.0061
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0044 0.001 0.001
Leishmania major hypothetical protein, conserved 0.0067 0.0061 0.5662
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.001 0.001
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0044 0.001 0.001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0009 0.0009
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Schistosoma mansoni nephrin 0.0068 0.0065 0.0065
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0044 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0044 0.001 0.001
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0731 0.1547 0.1547
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0067 0.0061 0.0343
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Echinococcus granulosus Pleckstrin y 0.0067 0.0061 0.0073
Echinococcus granulosus receptor type guanylyl cyclase 0.0044 0.001 0.0012
Echinococcus granulosus activated cdc42 kinase 1 0.0044 0.001 0.0012
Echinococcus multilocularis protein kinase 0.0044 0.001 0.0012
Brugia malayi TBC domain containing protein 0.0067 0.0061 0.0061
Loa Loa (eye worm) TK protein kinase 0.0044 0.001 0.001
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.001 0.001
Toxoplasma gondii hypothetical protein 0.0067 0.0061 0.5662
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Entamoeba histolytica PH domain containing protein kinase, putative 0.0085 0.0102 0.0596
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0044 0.001 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0061 0.0343
Brugia malayi Regulator of G protein signaling domain containing protein 0.0731 0.1547 0.1547
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0067 0.0061 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0061 0.0343
Echinococcus multilocularis Regulator of G protein signaling 20 0.0731 0.1547 0.185
Echinococcus granulosus tyrosine protein kinase Src64B 0.0044 0.001 0.0012
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0062 0.0051 0.4497
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0085 0.0102 1
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.021 0.1311
Echinococcus multilocularis protein kinase 0.0044 0.001 0.0012
Brugia malayi PH domain containing protein 0.0067 0.0061 0.0061
Schistosoma mansoni regulator of G protein signaling 0.0731 0.1547 0.1547
Echinococcus multilocularis pdz domain containing protein 0.0067 0.0061 0.0073
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0731 0.1547 0.1547
Mycobacterium ulcerans hypothetical protein 0.0043 0.0009 0.5
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Schistosoma mansoni tyrosine protein kinase 0.0044 0.001 0.001
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0067 0.0061 0.0061
Trichomonas vaginalis AGC family protein kinase 0.0076 0.0081 0.0472
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Schistosoma mansoni hypothetical protein 0.0067 0.0061 0.0061
Echinococcus granulosus aurora kinase A 0.0076 0.0081 0.0097
Onchocerca volvulus 0.0717 0.1516 1
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0044 0.001 0.0012
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.001 0.001
Entamoeba histolytica protein kinase, putative 0.0085 0.0102 0.0596
Echinococcus granulosus regulator of G protein signaling 3 0.0731 0.1547 0.185
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Echinococcus multilocularis tyrosine protein kinase csk 0.0044 0.001 0.0012
Echinococcus multilocularis tyrosine protein kinase HCK 0.0044 0.001 0.0012
Echinococcus multilocularis integrin linked protein kinase 0.0044 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0067 0.0061 0.0061
Brugia malayi beta-lactamase 0.0043 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.021 0.1311
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Trypanosoma cruzi PH domain containing protein, putative 0.0067 0.0061 0.5662
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0062 0.0051 0.006
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0044 0.001 0.0158
Loa Loa (eye worm) hypothetical protein 0.0067 0.0061 0.0061
Echinococcus granulosus dynamin 1 0.0067 0.0061 0.0073
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.021 0.1311
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0044 0.001 0.0012
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Echinococcus granulosus semaphorin 5B 0.0305 0.0594 0.071
Entamoeba histolytica hypothetical protein 0.0134 0.021 0.1303
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.001 0.001
Schistosoma mansoni ephrin receptor 0.0044 0.001 0.001
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0044 0.001 0.0012
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0067 0.0061 0.0343
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.001 0.001
Echinococcus multilocularis tyrosine protein kinase Srms 0.0044 0.001 0.0012
Echinococcus granulosus axis inhibition protein axin 0.0731 0.1547 0.185
Brugia malayi hypothetical protein 0.0731 0.1547 0.1547
Trypanosoma cruzi NIMA-related kinase, putative 0.0085 0.0102 1
Schistosoma mansoni protein kinase 0.0062 0.0051 0.0051
Schistosoma mansoni serine/threonine-protein kinase 0.0085 0.0102 0.0102
Echinococcus granulosus oxysterol binding protein 1 0.0067 0.0061 0.0073
Loa Loa (eye worm) TK/EGFR protein kinase 0.0044 0.001 0.001
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0044 0.001 0.0012
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0009 0.5
Loa Loa (eye worm) TK/INSR protein kinase 0.0044 0.001 0.001
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0067 0.0061 0.0333
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.3776 0.8364 0.8364
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0035 0.0042
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0009 0.5
Entamoeba histolytica PH domain containing protein 0.0067 0.0061 0.0333
Entamoeba histolytica protein kinase , putative 0.0076 0.0081 0.0463
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0305 0.0594 0.0594
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0041 0.0041
Plasmodium vivax hypothetical protein, conserved 0.0067 0.0061 0.5662
Brugia malayi hypothetical protein 0.0044 0.001 0.001
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0008 0.0008
Entamoeba histolytica protein kinase, putative 0.0085 0.0102 0.0596
Toxoplasma gondii protein kinase domain-containing protein 0.0085 0.0102 1
Echinococcus multilocularis c src tyrosine kinase 0.0044 0.001 0.0012
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0044 0.001 0.0012
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0044 0.001 0.0012
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Echinococcus granulosus tyrosine protein kinase csk 0.0044 0.001 0.0012
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0044 0.001 0.001
Echinococcus multilocularis oxysterol binding protein 9 0.0067 0.0061 0.0073
Echinococcus granulosus Oxysterol binding protein 11 0.0067 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.0731 0.1547 0.1547
Leishmania major hypothetical protein, conserved 0.0044 0.001 0.0158
Brugia malayi hypothetical protein 0.0067 0.0061 0.0061
Echinococcus multilocularis GRB2 associated binding protein 3 0.0067 0.0061 0.0073
Brugia malayi PH domain containing protein 0.0067 0.0061 0.0061
Brugia malayi PH domain containing protein 0.0067 0.0061 0.0061
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0067 0.0061 0.5662
Onchocerca volvulus 0.0067 0.0061 0.035
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Toxoplasma gondii phosphatidylinositol transfer protein 0.0067 0.0061 0.5662
Schistosoma mansoni hypothetical protein 0.0305 0.0594 0.0594
Entamoeba histolytica PH domain containing protein kinase, putative 0.0085 0.0102 0.0596
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.001 0.001
Schistosoma mansoni regulator of G protein signaling 0.0731 0.1547 0.1547
Schistosoma mansoni serine/threonine protein kinase 0.3454 0.7645 0.7645
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0067 0.0061 0.5662
Loa Loa (eye worm) PH domain-containing protein 0.0067 0.0061 0.0061
Echinococcus multilocularis calcium dependent secretion activator 1 0.0067 0.0061 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Echinococcus granulosus protein tyrosine kinase 0.0044 0.001 0.0012
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0063 0.0054 0.0054
Loa Loa (eye worm) TK/ROR protein kinase 0.0044 0.001 0.001
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0044 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0044 0.001 0.001
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0067 0.0061 0.0343
Schistosoma mansoni protein kinase 0.0044 0.001 0.001
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.3776 0.8364 1
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Loa Loa (eye worm) PXA domain-containing protein 0.0731 0.1547 0.1547
Loa Loa (eye worm) hypothetical protein 0.0731 0.1547 0.1547
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Echinococcus granulosus oxysterol binding protein 9 0.0067 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.0067 0.0061 0.0061
Echinococcus multilocularis axis inhibition protein axin 0.0731 0.1547 0.185
Echinococcus multilocularis regulator of G protein signaling 0.0731 0.1547 0.185
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0076 0.0081 0.0463
Entamoeba histolytica PH domain containing protein 0.0067 0.0061 0.0333
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Trichomonas vaginalis centaurin/arf, putative 0.0067 0.0061 0.0343
Entamoeba histolytica hypothetical protein, conserved 0.0067 0.0061 0.0333
Brugia malayi Receptor family ligand binding region containing protein 0.0044 0.001 0.001
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0044 0.001 0.001
Schistosoma mansoni oxysterol-binding protein 1 0.0067 0.0061 0.0061
Brugia malayi Sema domain containing protein 0.0305 0.0594 0.0594
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0044 0.001 0.0012
Trypanosoma cruzi hypothetical protein 0.0067 0.0061 0.5662
Brugia malayi hypothetical protein 0.0305 0.0594 0.0594
Schistosoma mansoni protein kinase 0.0062 0.0051 0.0051
Echinococcus multilocularis Rho GTPase activating protein 24 0.0067 0.0061 0.0073
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0044 0.001 0.0158
Brugia malayi Uncoordinated protein 104 0.0067 0.0061 0.0061
Echinococcus multilocularis oxysterol binding protein 3 0.0067 0.0061 0.0073
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0035 0.0035
Echinococcus multilocularis protein tyrosine kinase 0.0044 0.001 0.0012
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0067 0.0061 0.0073
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0000059075 0.0000059075
Echinococcus granulosus Rho GTPase activating protein 24 0.0067 0.0061 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.021 0.1311
Echinococcus granulosus epidermal growth factor receptor 0.0044 0.001 0.0012
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0067 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Echinococcus granulosus cytohesin 1 0.0067 0.0061 0.0073
Echinococcus multilocularis natriuretic peptide receptor 1 0.0044 0.001 0.0012
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0044 0.001 0.0012
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Brugia malayi PXA domain containing protein 0.0731 0.1547 0.1547
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.001 0.0012
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0041 0.0041
Loa Loa (eye worm) sema domain-containing protein 0.0305 0.0594 0.0594
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0067 0.0061 0.0333
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0533 1
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.001 0.001
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0067 0.0061 0.0073
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0044 0.001 0.001
Loa Loa (eye worm) TK/EPH protein kinase 0.0044 0.001 0.001
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0067 0.0061 0.0333
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Loa Loa (eye worm) cytohesin 3 0.0067 0.0061 0.0061
Schistosoma mansoni zinc finger protein 0.0067 0.0061 0.0061
Loa Loa (eye worm) TK/FAK protein kinase 0.0044 0.001 0.001
Echinococcus granulosus Immunoglobulin 0.0063 0.0054 0.0064
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.001 0.001
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Plasmodium falciparum serine/threonine protein kinase, putative 0.0076 0.0081 0.7762
Toxoplasma gondii aurora kinase 0.0076 0.0081 0.7798
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.021 0.1311
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0044 0.001 0.001
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0067 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.0044 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0305 0.0594 0.0594
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0134 0.021 0.1311
Loa Loa (eye worm) hypothetical protein 0.0068 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0063 0.0054 0.0054
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Loa Loa (eye worm) TK protein kinase 0.0044 0.001 0.001
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0044 0.001 0.0012
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0044 0.001 0.0012
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0044 0.001 0.0012
Loa Loa (eye worm) RGC/RGC protein kinase 0.0044 0.001 0.001
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0067 0.0061 0.0073
Echinococcus granulosus tyrosine protein kinase pr2 0.0044 0.001 0.0012
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0134 0.021 0.1311
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0062 0.0051 0.4497
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.001 0.001
Entamoeba histolytica PH domain containing protein kinase, putative 0.0085 0.0102 0.0596
Brugia malayi PH domain containing protein 0.0067 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.021 0.1311
Schistosoma mansoni regulator of G protein signaling 0.0731 0.1547 0.1547
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0044 0.001 0.0012
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0044 0.001 0.0012
Entamoeba histolytica protein kinase, putative 0.0085 0.0102 0.0596
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Toxoplasma gondii Oxysterol-binding protein 0.0067 0.0061 0.5662
Brugia malayi Furin-like cysteine rich region family protein 0.0044 0.001 0.001
Onchocerca volvulus Putative zinc finger protein 0.0067 0.0061 0.035
Schistosoma mansoni hypothetical protein 0.0067 0.0061 0.0061
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0731 0.1547 1
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0067 0.0061 0.0343
Loa Loa (eye worm) uncoordinated protein 104 0.0067 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0009
Echinococcus multilocularis tyrosine protein kinase csk 0.0044 0.001 0.0012
Loa Loa (eye worm) beta-lactamase 0.0043 0.0009 0.0009
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0067 0.0061 0.0333
Loa Loa (eye worm) hypothetical protein 0.0044 0.001 0.001
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0085 0.0102 1
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Brugia malayi Syntrophin-1 0.0067 0.0061 0.0061
Loa Loa (eye worm) TK protein kinase 0.0044 0.001 0.001
Echinococcus multilocularis tyrosine protein kinase Abl 0.0044 0.001 0.0012
Brugia malayi Plekhf2 protein 0.0067 0.0061 0.0061
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0044 0.001 0.0012
Loa Loa (eye worm) TK/RYK protein kinase 0.0044 0.001 0.001
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Trypanosoma cruzi protein kinase, putative 0.0044 0.001 0.0158
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Loa Loa (eye worm) hypothetical protein 0.0305 0.0594 0.0594
Plasmodium falciparum calcium-dependent protein kinase 7 0.0085 0.0102 1
Schistosoma mansoni hypothetical protein 0.0067 0.0061 0.0061
Trypanosoma cruzi hypothetical protein 0.0067 0.0061 0.5662
Loa Loa (eye worm) hypothetical protein 0.0058 0.0041 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0061 0.0343
Brugia malayi hypothetical protein 0.0044 0.001 0.001
Schistosoma mansoni dynamin 0.0067 0.0061 0.0061
Schistosoma mansoni regulator of G protein signaling 0.0731 0.1547 0.1547
Trypanosoma brucei protein kinase, putative 0.0085 0.0102 1
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0085 0.0102 1
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0067 0.0061 0.5592
Echinococcus multilocularis raf serine:threonine protein kinase 0.0044 0.001 0.0012
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0067 0.0061 0.0333
Echinococcus multilocularis tyrosine protein kinase Blk 0.0044 0.001 0.0012
Brugia malayi serine/threonine-protein kinase 6 0.0076 0.0081 0.0081
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0085 0.0102 0.0605
Giardia lamblia Aurora kinase 0.0076 0.0081 1
Echinococcus granulosus protein kinase 0.0044 0.001 0.0012
Brugia malayi Sema domain containing protein 0.0305 0.0594 0.0594
Loa Loa (eye worm) AUR protein kinase 0.0076 0.0081 0.0081
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0108 0.0152 0.0152
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0067 0.0061 0.0061
Echinococcus multilocularis regulator of G protein signaling 3 0.0731 0.1547 0.185
Schistosoma mansoni zinc finger protein 0.0067 0.0061 0.0061
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0044 0.001 0.0012
Schistosoma mansoni protein kinase 0.0044 0.001 0.001
Schistosoma mansoni protein kinase 0.0044 0.001 0.001
Echinococcus granulosus retinal guanylyl cyclase 2 0.0044 0.001 0.0012
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0067 0.0061 0.5662
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0081 0.0081
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0067 0.0061 0.0073
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0067 0.0061 0.0073
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0044 0.001 0.0012
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Plasmodium vivax tyrosine kinase-like protein, putative 0.0044 0.001 0.0158
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0035 0.0042
Leishmania major protein kinase, putative 0.0085 0.0102 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.001 0.001
Echinococcus multilocularis Immunoglobulin 0.0063 0.0054 0.0064
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Leishmania major folate/biopterin transporter, putative 0.0085 0.0102 1
Schistosoma mansoni plexin 0.0412 0.0833 0.0833
Schistosoma mansoni serine/threonine RGC 0.0044 0.001 0.001
Echinococcus multilocularis receptor type guanylyl cyclase 0.0044 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0068 0.0065 0.0065
Echinococcus multilocularis semaphorin 5B 0.0305 0.0594 0.071
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0044 0.001 0.0012
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.0051 0.0263
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Echinococcus multilocularis transcription factor collier 0.0134 0.021 0.0252
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0067 0.0061 0.0343
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0044 0.001 0.001
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0044 0.001 0.001
Entamoeba histolytica ARF GTPase activating protein, putative 0.0067 0.0061 0.0333
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0009 0.001
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Echinococcus multilocularis exocyst complex component 2 0.0134 0.021 0.0252
Trichomonas vaginalis AGC family protein kinase 0.0076 0.0081 0.0472
Echinococcus multilocularis FL cytokine receptor 0.0044 0.001 0.0012
Echinococcus multilocularis aurora kinase A 0.0076 0.0081 0.0097
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0044 0.001 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0085 0.0102 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0044 0.001 0.0012
Schistosoma mansoni ephrin receptor 0.0049 0.0021 0.0021
Echinococcus granulosus serine/threonine protein kinase 0.0085 0.0102 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0061 0.0343
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0044 0.001 0.0012
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Brugia malayi serine/threonine kinase 12 0.0076 0.0081 0.0081
Echinococcus granulosus c src tyrosine kinase 0.0044 0.001 0.0012
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0134 0.021 0.1311
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0061 0.0343
Entamoeba histolytica hypothetical protein 0.0085 0.0102 0.0596
Loa Loa (eye worm) TK/ALK protein kinase 0.031 0.0607 0.0607
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.001 0.001
Trypanosoma cruzi hypothetical protein 0.0067 0.0061 0.5662
Leishmania major serine/threonine-protein kinase a, putative 0.0085 0.0102 1
Schistosoma mansoni hypothetical protein 0.0412 0.0833 0.0833
Loa Loa (eye worm) RGS-3 protein 0.0731 0.1547 0.1547
Echinococcus granulosus tyrosine protein kinase Fyn 0.0044 0.001 0.0012
Echinococcus granulosus tyrosine protein kinase Src42A 0.0044 0.001 0.0012
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0134 0.021 0.1311
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0061 0.0343
Trypanosoma cruzi NIMA-related kinase, putative 0.0085 0.0102 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.001 0.001
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0731 0.1547 0.185
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0061 0.0343
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0044 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0731 0.1547 1
Loa Loa (eye worm) hypothetical protein 0.0412 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0067 0.0061 0.0061
Schistosoma mansoni serine/threonine protein kinase 0.3454 0.7645 0.7645
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0067 0.0061 0.0333
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0044 0.001 0.001
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0067 0.0061 0.0333
Loa Loa (eye worm) hypothetical protein 0.0731 0.1547 0.1547
Brugia malayi C-terminal src kinase protein 1 0.0044 0.001 0.001
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0067 0.0061 0.0333
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.001 0.001
Echinococcus multilocularis dynamin 1 0.0067 0.0061 0.0073
Echinococcus granulosus tyrosine protein kinase HCK 0.0044 0.001 0.0012
Leishmania major protein kinase, putative 0.0062 0.0051 0.4497
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0067 0.0061 0.0073
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0063 0.0054 0.0064
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Trichomonas vaginalis TK family protein kinase 0.0044 0.001 0.001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0009 0.0009
Loa Loa (eye worm) Plekhf2 protein 0.0067 0.0061 0.0061
Echinococcus multilocularis neuroglian 0.0063 0.0054 0.0064
Echinococcus granulosus regulator of G protein signaling 7 0.0731 0.1547 0.185
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Entamoeba histolytica hypothetical protein 0.0731 0.1547 1
Entamoeba histolytica p21-activated kinase 0.0085 0.0102 0.0596
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0044 0.001 0.001
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0062 0.0051 0.4497
Brugia malayi Dynamin 0.0067 0.0061 0.0061
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0044 0.001 0.001
Echinococcus granulosus defective proboscis extension response 0.0063 0.0054 0.0064
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.001 0.001
Brugia malayi Immunoglobulin I-set domain containing protein 0.0108 0.0152 0.0152
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Echinococcus granulosus G protein coupled receptor kinase 1 0.2723 0.6009 0.7184
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Echinococcus multilocularis protein KINase family member (kin 25) 0.0044 0.001 0.0012
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0062 0.0051 0.4497
Toxoplasma gondii protein kinase domain-containing protein 0.0044 0.001 0.0158
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0035 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.3776 0.8364 0.8364
Plasmodium falciparum oxysterol-binding protein, putative 0.0067 0.0061 0.5592
Brugia malayi Plexin repeat family protein 0.0717 0.1516 0.1516
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Brugia malayi Immunoglobulin I-set domain containing protein 0.0068 0.0065 0.0065
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0063 0.0054 0.0054
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0067 0.0061 0.0061
Schistosoma mansoni protein kinase 0.0044 0.001 0.001
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0009 0.0009
Toxoplasma gondii hypothetical protein 0.0067 0.0061 0.5662
Loa Loa (eye worm) AUR protein kinase 0.0076 0.0081 0.0081
Echinococcus granulosus tyrosine protein kinase shark 0.0044 0.001 0.0012
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0044 0.001 0.0012
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Loa Loa (eye worm) TK protein kinase 0.0044 0.001 0.001
Trichomonas vaginalis alpha chimerin, putative 0.0067 0.0061 0.0343
Leishmania major hypothetical protein, conserved 0.0067 0.0061 0.5662
Onchocerca volvulus 0.0044 0.001 0.001
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Echinococcus granulosus raf serine:threonine protein kinase 0.0044 0.001 0.0012
Brugia malayi Tyrosine-protein kinase PR2 0.0044 0.001 0.001
Plasmodium falciparum PH domain-containing protein, putative 0.0067 0.0061 0.5592
Echinococcus granulosus tyrosine protein kinase Lyn 0.0062 0.0051 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0061 0.0343
Trichomonas vaginalis protein transport protein sec7, putative 0.0067 0.0061 0.0343
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0044 0.001 0.0012
Onchocerca volvulus 0.0044 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0067 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0044 0.001 0.001
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0044 0.001 0.001
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0731 0.1547 0.1547
Schistosoma mansoni serine/threonine-protein kinase 0.0085 0.0102 0.0102
Echinococcus granulosus axis inhibition protein axin 0.0731 0.1547 0.185
Onchocerca volvulus Protein melted homolog 0.0067 0.0061 0.035
Loa Loa (eye worm) syntrophin-1 0.0067 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0731 0.1547 0.1547
Schistosoma mansoni hypothetical protein 0.0134 0.021 0.021
Echinococcus multilocularis hypothetical protein 0.0305 0.0594 0.071
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0067 0.0061 0.0073
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0067 0.0061 0.5592
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0067 0.0061 0.0073
Echinococcus granulosus expressed protein 0.0731 0.1547 0.185
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0061 0.0343
Schistosoma mansoni hypothetical protein 0.0044 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0044 0.001 0.001
Trypanosoma cruzi PH domain containing protein, putative 0.0067 0.0061 0.5662
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0044 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0731 0.1547 0.1547
Trichomonas vaginalis hypothetical protein 0.0067 0.0061 0.0343
Loa Loa (eye worm) hypothetical protein 0.0067 0.0061 0.0061
Entamoeba histolytica hypothetical protein 0.0134 0.021 0.1303
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0067 0.0061 0.5662
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0044 0.001 0.0012
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0067 0.0061 0.035
Trichomonas vaginalis conserved hypothetical protein 0.0731 0.1547 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0044 0.001 0.001
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0067 0.0061 0.0061
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.001 0.001
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0067 0.0061 0.035
Echinococcus multilocularis G protein coupled receptor kinase 6 0.3776 0.8364 1
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0009
Schistosoma mansoni centaurin alpha 0.0067 0.0061 0.0061
Brugia malayi bone morphogenetic protein type 1 receptor 0.0044 0.001 0.001
Onchocerca volvulus 0.0044 0.001 0.001
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.3776 0.8364 0.8364
Entamoeba histolytica cell surface protease gp63, putative 0.0134 0.021 0.1303
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Brugia malayi Oxysterol binding protein 0.0067 0.0061 0.0061
Entamoeba histolytica protein kinase, putative 0.0085 0.0102 0.0596
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0009 0.5
Onchocerca volvulus outspread protein homolog 0.0067 0.0061 0.035
Echinococcus multilocularis Pleckstrin y 0.0067 0.0061 0.0073
Brugia malayi hypothetical protein 0.0305 0.0594 0.0594
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Echinococcus multilocularis transfer RNA-Thr 0.0044 0.001 0.0012
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0076 0.0081 0.0463
Toxoplasma gondii STE kinase 0.0044 0.001 0.0158
Trichomonas vaginalis kinesin light chain, putative 0.0067 0.0061 0.0343
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0085 0.0102 1
Schistosoma mansoni syntrophin 0.0067 0.0061 0.0061
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0067 0.0061 0.0073
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0067 0.0061 0.5662
Onchocerca volvulus 0.0044 0.001 0.001
Echinococcus multilocularis ephrin type A receptor 4 A 0.0044 0.001 0.0012
Schistosoma mansoni protein kinase 0.0044 0.001 0.001
Brugia malayi Raf kinase 0.0044 0.001 0.001
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Schistosoma mansoni axis inhibition protein axin 0.0731 0.1547 0.1547
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0067 0.0061 0.0333
Brugia malayi Fibronectin type III domain containing protein 0.0068 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0731 0.1547 0.1547
Loa Loa (eye worm) serine/threonine protein kinase 0.0044 0.001 0.001
Echinococcus granulosus integrin linked protein kinase 0.0044 0.001 0.0012
Echinococcus multilocularis activin receptor type 0.0062 0.0051 0.006
Entamoeba histolytica PH domain containing protein kinase, putative 0.0085 0.0102 0.0596
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.001 0.001
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0044 0.001 0.001
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0067 0.0061 0.0061
Echinococcus multilocularis myotubularin protein 13 0.0067 0.0061 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0067 0.0061 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.001 0.001
Echinococcus granulosus DCC interacting protein 13 beta 0.0067 0.0061 0.0073
Schistosoma mansoni protein tyrosine kinase 0.0044 0.001 0.001
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Echinococcus multilocularis regulator of G protein signaling 7 0.0731 0.1547 0.185
Echinococcus granulosus activated cdc42 kinase 1 0.0044 0.001 0.0012
Schistosoma mansoni axis inhibition protein axin 0.0731 0.1547 0.1547
Brugia malayi plexin A 0.085 0.1815 0.1815
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.001 0.001
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Loa Loa (eye worm) hypothetical protein 0.0063 0.0054 0.0054
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Echinococcus granulosus calcium dependent secretion activator 1 0.0067 0.0061 0.0073
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0062 0.0051 0.006
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Brugia malayi hypothetical protein 0.0044 0.001 0.001
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0044 0.001 0.001
Loa Loa (eye worm) TK protein kinase 0.0044 0.001 0.001
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0067 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.0067 0.0061 0.0061
Schistosoma mansoni protein kinase 0.0044 0.001 0.001
Entamoeba histolytica hypothetical protein 0.0067 0.0061 0.0333
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0067 0.0061 0.0333
Brugia malayi beta-lactamase family protein 0.0043 0.0009 0.0009
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Echinococcus granulosus exocyst complex component 2 0.0134 0.021 0.0252
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Onchocerca volvulus 0.0044 0.001 0.001
Onchocerca volvulus 0.0305 0.0594 0.3883
Brugia malayi integrin-linked kinase 0.0044 0.001 0.001
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Loa Loa (eye worm) plexin A 0.085 0.1815 0.1815
Brugia malayi probable spectrin beta chain 0.0067 0.0061 0.0061
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0063 0.0054 0.0064
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0731 0.1547 1
Schistosoma mansoni cell adhesion molecule 0.0068 0.0065 0.0065
Toxoplasma gondii protein kinase 0.0044 0.001 0.0158
Echinococcus granulosus plexin a4 0.085 0.1815 0.217
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0044 0.001 0.0012
Entamoeba histolytica tyrosin kinase, putative 0.0178 0.0309 0.1946
Echinococcus granulosus roundabout 2 0.0068 0.0065 0.0077
Onchocerca volvulus 0.0067 0.0061 0.035
Echinococcus multilocularis pleckstrin y domain containing family A 0.0067 0.0061 0.0073
Echinococcus multilocularis tyrosine protein kinase 0.0044 0.001 0.0012
Echinococcus granulosus GRB2 associated binding protein 3 0.0067 0.0061 0.0073
Plasmodium falciparum protein kinase, putative 0.0062 0.0051 0.4408
Trypanosoma brucei rac serine-threonine kinase, putative 0.0085 0.0102 1
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0067 0.0061 0.0333
Trypanosoma cruzi aurora B kinase, putative 0.0076 0.0081 0.7798
Echinococcus multilocularis G protein coupled receptor kinase 1 0.2723 0.6009 0.7184
Brugia malayi SRC-1 0.0044 0.001 0.001
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0009
Plasmodium vivax PH domain containing protein 0.0067 0.0061 0.5662
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0009
Onchocerca volvulus 0.0044 0.001 0.001
Echinococcus granulosus regulator of G protein signaling 3 0.0731 0.1547 0.185
Loa Loa (eye worm) RGC/RGC protein kinase 0.0044 0.001 0.001
Echinococcus multilocularis cytohesin 1 0.0067 0.0061 0.0073
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0067 0.0061 0.0073
Onchocerca volvulus 0.0067 0.0061 0.035
Loa Loa (eye worm) TK protein kinase 0.0044 0.001 0.001
Brugia malayi A-kinase anchor protein 10, precursor 0.0731 0.1547 0.1547
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.4506 1 1
Loa Loa (eye worm) AUR protein kinase 0.0076 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0067 0.0061 0.0061
Echinococcus granulosus tyrosine kinase 0.0044 0.001 0.0012
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Loa Loa (eye worm) protein kinase domain-containing protein 0.0044 0.001 0.001
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0044 0.001 0.0012
Echinococcus granulosus tyrosine protein kinase Fyn 0.0044 0.001 0.0012
Plasmodium vivax tyrosine kinase-like protein, putative 0.0044 0.001 0.0158
Echinococcus multilocularis Immunoglobulin 0.0063 0.0054 0.0064
Echinococcus multilocularis activated cdc42 kinase 1 0.0044 0.001 0.0012
Schistosoma mansoni z-protein (S1r protein) 0.0731 0.1547 0.1547
Brugia malayi Dynamin 0.0067 0.0061 0.0061
Echinococcus multilocularis beta 1 syntrophin 0.0067 0.0061 0.0073
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0009 0.0009
Loa Loa (eye worm) TK protein kinase 0.0044 0.001 0.001
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0061 0.0343
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Echinococcus granulosus Pleckstrin y 0.0067 0.0061 0.0073
Echinococcus multilocularis insulin receptor 0.0044 0.001 0.0012
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0085 0.0102 1
Schistosoma mansoni vav2 0.0067 0.0061 0.0061
Schistosoma mansoni goodpasture antigen-binding protein 0.0067 0.0061 0.0061
Entamoeba histolytica hypothetical protein 0.0731 0.1547 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.001 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0731 0.1547 1
Entamoeba histolytica hypothetical protein 0.0067 0.0061 0.0333
Loa Loa (eye worm) hypothetical protein 0.0305 0.0594 0.0594
Trypanosoma brucei Pseudokinase, putative 0.0044 0.001 0.0158
Echinococcus granulosus semaphorin 1A 0.0305 0.0594 0.071
Brugia malayi DNA-binding protein LAG-1 0.0134 0.021 0.021
Trichomonas vaginalis STE family protein kinase 0.0044 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0134 0.021 0.021
Onchocerca volvulus 0.0044 0.001 0.001
Entamoeba histolytica PH domain containing protein 0.0067 0.0061 0.0333
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0044 0.001 0.0012
Loa Loa (eye worm) rho-GTPase-activating 0.0067 0.0061 0.0061
Echinococcus granulosus Pleckstrin y 0.0067 0.0061 0.0073
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0067 0.0061 0.0061
Schistosoma mansoni protein kinase 0.0044 0.001 0.001
Echinococcus multilocularis DCC interacting protein 13 beta 0.0067 0.0061 0.0073
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Brugia malayi Pleckstrin Homology Domain 0.0067 0.0061 0.0061
Onchocerca volvulus Tyrosine kinase homolog 0.0044 0.001 0.001
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Brugia malayi Variant SH3 domain containing protein 0.0067 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Onchocerca volvulus 0.0044 0.001 0.001
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0085 0.0102 1
Schistosoma mansoni protein kinase 0.0062 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0063 0.0054 0.0054
Brugia malayi Protein kinase domain containing protein 0.0085 0.0102 0.0102
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Echinococcus granulosus beta 1 syntrophin 0.0067 0.0061 0.0073
Brugia malayi SH2 domain containing protein 0.0044 0.001 0.001
Echinococcus granulosus insulin receptor 0.0044 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0063 0.0054 0.0054
Echinococcus granulosus tyrosine protein kinase Srms 0.0044 0.001 0.0012
Onchocerca volvulus 0.0044 0.001 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.001 0.001
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0044 0.001 0.0012
Echinococcus granulosus activin receptor type 0.0062 0.0051 0.006
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0049 0.0021 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0035 0.0035
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0044 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0063 0.0054 0.0054
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0731 0.1547 0.185
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0044 0.001 0.0012
Echinococcus multilocularis tyrosine kinase 0.0044 0.001 0.0012
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Trichomonas vaginalis protein transport protein sec7, putative 0.0067 0.0061 0.0343
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0067 0.0061 0.0061
Schistosoma mansoni protein kinase 0.0044 0.001 0.001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0035 0.0035
Echinococcus multilocularis beta adrenergic receptor kinase 0.3454 0.7645 0.914
Mycobacterium leprae Probable lipase LipE 0.0043 0.0009 0.5
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0044 0.001 0.001
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0085 0.0102 0.0605
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Echinococcus granulosus natriuretic peptide receptor 1 0.0044 0.001 0.0012
Schistosoma mansoni goodpasture antigen-binding protein 0.0067 0.0061 0.0061
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0085 0.0102 1
Schistosoma mansoni tyrosine kinase 0.0044 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0061 0.0343
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0076 0.0081 0.0097
Loa Loa (eye worm) AGC/AKT protein kinase 0.0085 0.0102 0.0102
Loa Loa (eye worm) TK protein kinase 0.0044 0.001 0.001
Brugia malayi PH domain containing protein 0.0067 0.0061 0.0061
Brugia malayi Guanylyl cyclase protein 23 0.0044 0.001 0.001
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Echinococcus granulosus transcription factor collier 0.0134 0.021 0.0252
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0044 0.001 0.0012
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Echinococcus granulosus retinal guanylyl cyclase 2 0.0044 0.001 0.0012
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0067 0.0061 0.0333
Entamoeba histolytica hypothetical protein 0.0085 0.0102 0.0596
Brugia malayi Oxysterol-binding protein 0.0067 0.0061 0.0061
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.0081 0.0463
Echinococcus granulosus ephrin type A receptor 4 A 0.0044 0.001 0.0012
Brugia malayi PH domain containing protein 0.0067 0.0061 0.0061
Echinococcus multilocularis tyrosine protein kinase pr2 0.0044 0.001 0.0012
Entamoeba histolytica hypothetical protein 0.0731 0.1547 1
Echinococcus multilocularis Ras associated and pleckstrin y 0.0067 0.0061 0.0073
Leishmania major protein kinase, putative 0.0076 0.0081 0.7798
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0067 0.0061 0.0073
Mycobacterium ulcerans beta-lactamase 0.0043 0.0009 0.5
Trichomonas vaginalis protein kinase atn1, putative 0.0044 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0134 0.021 0.021
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0049 0.0021 0.0025
Loa Loa (eye worm) RGC/RGC protein kinase 0.0044 0.001 0.001
Echinococcus granulosus tyrosine protein kinase ABL1 0.0044 0.001 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0061 0.0343
Loa Loa (eye worm) hypothetical protein 0.0731 0.1547 0.1547
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Echinococcus granulosus Regulator of G protein signaling 20 0.0731 0.1547 0.185
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0067 0.0061 0.0061
Brugia malayi protein-tyrosine kinase 0.0044 0.001 0.001
Echinococcus multilocularis Oxysterol binding protein 11 0.0067 0.0061 0.0073
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.001 0.0012
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0085 0.0102 1
Brugia malayi MAX-1A 0.0067 0.0061 0.0061
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0044 0.001 0.001
Schistosoma mansoni serine/threonine protein kinase 0.4506 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.001 0.001
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0067 0.0061 0.5592
Brugia malayi regulator of G-protein signaling rgs-7 0.0731 0.1547 0.1547
Loa Loa (eye worm) hypothetical protein 0.0234 0.0436 0.0436
Brugia malayi PH domain containing protein 0.0067 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0134 0.021 0.021
Trypanosoma brucei aurora B kinase 0.0076 0.0081 0.7798
Brugia malayi Regulator of G protein signaling domain containing protein 0.0731 0.1547 0.1547
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Echinococcus granulosus pleckstrin y domain containing family A 0.0067 0.0061 0.0073
Brugia malayi Protein kinase domain containing protein 0.0044 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0061 0.0343
Schistosoma mansoni oxysterol-binding protein 1 0.0067 0.0061 0.0061
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0085 0.0102 1
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0134 0.021 0.1311
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.001 0.0012
Loa Loa (eye worm) TK protein kinase 0.0044 0.001 0.001
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0085 0.0102 1
Loa Loa (eye worm) hypothetical protein 0.0717 0.1516 0.1516
Trichomonas vaginalis protein tyrosine kinase, putative 0.0044 0.001 0.001
Onchocerca volvulus 0.0044 0.001 0.001
Mycobacterium ulcerans lipase LipD 0.0043 0.0009 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.001 0.0012
Schistosoma mansoni semaphorin 5-related 0.0305 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0305 0.0594 0.0594
Echinococcus multilocularis plexin a4 0.085 0.1815 0.217
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.3454 0.7645 0.7645
Brugia malayi PH domain containing protein 0.0067 0.0061 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0044 0.001 0.001
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0008 0.0008
Echinococcus granulosus regulator of G protein signaling 7 0.0731 0.1547 0.185
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Loa Loa (eye worm) SRC-1 0.0044 0.001 0.001
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0044 0.001 0.001
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0076 0.0081 0.0097
Entamoeba histolytica protein kinase, putative 0.0085 0.0102 0.0596
Echinococcus granulosus pdz domain containing protein 0.0067 0.0061 0.0073
Brugia malayi ephrin receptor 1 precursor 0.0044 0.001 0.001
Echinococcus multilocularis axis inhibition protein axin 0.0731 0.1547 0.185
Brugia malayi regulator of G-protein signaling egl-10 0.0731 0.1547 0.1547
Entamoeba histolytica hypothetical protein 0.0134 0.021 0.1303
Echinococcus granulosus tyrosine kinase 0.0044 0.001 0.0012
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0085 0.0102 1
Trypanosoma brucei protein kinase, putative 0.0062 0.0051 0.4497
Entamoeba histolytica hypothetical protein 0.0067 0.0061 0.0333
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Onchocerca volvulus 0.0067 0.0061 0.035
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0102 0.0605
Trichomonas vaginalis TKL family protein kinase 0.0044 0.001 0.001
Brugia malayi serine/threonine protein kinase 6 0.0076 0.0081 0.0081

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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