Detailed information for compound 1404959

Basic information

Technical information
  • TDR Targets ID: 1404959
  • Name: [8-ethyl-3-(hydroxymethyl)-1-oxa-4-azaspiro[4 .5]decan-3-yl]methanol
  • MW: 229.316 | Formula: C12H23NO3
  • H donors: 3 H acceptors: 2 LogP: 0.46 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1CCC2(CC1)OCC(N2)(CO)CO
  • InChi: 1S/C12H23NO3/c1-2-10-3-5-12(6-4-10)13-11(7-14,8-15)9-16-12/h10,13-15H,2-9H2,1H3
  • InChiKey: XRNYLYFHWOZHAA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (8-ethyl-3-methylol-1-oxa-4-azaspiro[4.5]decan-3-yl)methanol
  • (8-Ethyl-3-hydroxymethyl-1-oxa-4-aza-spiro[4.5]dec-3-yl)-methanol
  • MLS000030741
  • SMR000011268
  • IVK/9091910
  • BAS 02311857
  • Oprea1_732600
  • EU-0050016
  • Oprea1_670712

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis expressed protein 0.0034 0.0154 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0012 0.0041
Loa Loa (eye worm) hypothetical protein 0.1071 0.7411 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0061 0.018
Schistosoma mansoni cytochrome P450 0.003 0.0126 0.0125
Chlamydia trachomatis protoporphyrinogen oxidase 0.0234 0.1556 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0012 0.0041
Echinococcus granulosus GPCR family 2 0.0016 0.0026 0.0025
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.015 0.0477
Schistosoma mansoni cpg binding protein 0.006 0.0339 0.0338
Brugia malayi Endoplasmin precursor 0.0035 0.016 0.0215
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0306 0.2061 0.6852
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0061 0.006
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0052 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0227 0.0756
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0199 0.0513
Brugia malayi TAR-binding protein 0.0131 0.0833 0.1123
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0061 0.006
Leishmania major eukaryotic initiation factor 4a, putative 0.0441 0.3004 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.003 0.0126 0.0396
Echinococcus multilocularis ubiquinone biosynthesis monooxygenase COQ6 0.0081 0.0484 0.0484
Toxoplasma gondii heat shock protein HSP90 0.0035 0.016 0.051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0303 0.0303
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0016 0.002
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Leishmania major trypanothione reductase 0.0037 0.0178 0.0569
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.003 0.0126 0.0221
Loa Loa (eye worm) hypothetical protein 0.0016 0.0026 0.0034
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0512 0.1353
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0306 0.0996
Echinococcus granulosus dna polymerase eta 0.0021 0.0061 0.006
Brugia malayi Uncoordinated protein 44 0.0014 0.0016 0.002
Chlamydia trachomatis pyruvate kinase 0.004 0.0199 0.1236
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0261 0.0351
Trypanosoma cruzi heat shock protein 90, putative 0.0028 0.011 0.0344
Trypanosoma cruzi cytochrome P450, putative 0.0058 0.0323 0.1052
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0991 0.6849 0.6849
Echinococcus granulosus death domain containing protein 0.0014 0.0016 0.0015
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0306 0.1018
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0218 0.0704
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0021 0.0069
Plasmodium falciparum endoplasmin, putative 0.0021 0.0066 0.0196
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0441 0.3004 0.8025
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0026 0.0025
Schistosoma mansoni ap endonuclease 0.0019 0.0052 0.0052
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0178 0.0569
Mycobacterium ulcerans heat shock protein 90 0.0028 0.011 0.0192
Toxoplasma gondii FAD binding domain-containing protein 0.0081 0.0484 0.1592
Toxoplasma gondii hypothetical protein 0.0049 0.0263 0.0852
Entamoeba histolytica hypothetical protein 0.0035 0.0165 0.0497
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.003 0.0126 0.0221
Loa Loa (eye worm) TAR-binding protein 0.0131 0.0833 0.1123
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.018
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0479 0.1593
Schistosoma mansoni hypothetical protein 0.0348 0.2354 0.2353
Echinococcus granulosus lysine specific histone demethylase 1A 0.0234 0.1556 0.1556
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0484 0.1592
Toxoplasma gondii thioredoxin reductase 0.0037 0.0178 0.0569
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0014 0.0016 0.0016
Trypanosoma cruzi UDP-galactopyranose mutase 0.0234 0.1556 0.5169
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.0022 0.0021
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0306 0.0996
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0016 0.0015
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0227 0.0226
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.003 0.0126 0.0221
Leishmania major protein kinase, putative 0.0016 0.0025 0.0061
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.1046 0.2782
Brugia malayi Pre-SET motif family protein 0.0225 0.1489 0.2009
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0781 0.5382 1
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0441 0.3004 0.3004
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0234 0.1556 0.5169
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.018
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0479 0.1593
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0579 0.1531
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0061 0.018
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0026 0.0062
Leishmania major pyruvate kinase 0.004 0.0199 0.0639
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0306 0.0996
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0268 0.0267
Echinococcus granulosus geminin 0.0348 0.2354 0.2353
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0007 0.0009
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0113 0.0152
Loa Loa (eye worm) pyruvate kinase 0.004 0.0199 0.0267
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0339 0.0456
Schistosoma mansoni hypothetical protein 0.0421 0.2864 0.2864
Echinococcus granulosus tar DNA binding protein 0.0131 0.0833 0.0833
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0164 0.0544
Trypanosoma brucei kynurenine 3-monooxygenase, putative 0.0081 0.0484 0.1592
Trypanosoma brucei heat shock protein, putative 0.0035 0.016 0.051
Echinococcus multilocularis pyruvate kinase 0.004 0.0199 0.0198
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0227 0.0226
Leishmania major mitochondrial DNA polymerase beta 0.0306 0.2061 0.6852
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0026 0.0025
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Brugia malayi SWIRM domain containing protein 0.1071 0.7411 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0052 0.015
Plasmodium vivax hypothetical protein, conserved 0.0234 0.1556 0.5169
Leishmania major lanosterol 14-alpha-demethylase, putative 0.003 0.0126 0.0396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0147 0.0491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0147 0.0491
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0026 0.0062
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0025 0.0061
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0012 0.0041
Plasmodium falciparum heat shock protein 90 0.0035 0.016 0.051
Echinococcus granulosus cpg binding protein 0.0064 0.0363 0.0362
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0306 0.1018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0303 0.0303
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0441 0.3004 1
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0149 0.0472
Schistosoma mansoni hypothetical protein 0.0016 0.0026 0.0025
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0061 0.015
Plasmodium falciparum pyruvate kinase 0.004 0.0199 0.0639
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0218 0.0704
Trypanosoma cruzi cytochrome p450-like protein, putative 0.003 0.0126 0.0396
Echinococcus granulosus eukaryotic initiation factor 4A 0.0441 0.3004 0.3004
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.0833 0.1123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0227 0.0756
Brugia malayi amine oxidase, flavin-containing family protein 0.0315 0.2118 0.2857
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0012 0.0041
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.003 0.0126 0.0221
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0441 0.3004 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0102 0.034
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0021 0.0045
Plasmodium falciparum pyruvate kinase 2 0.0021 0.0061 0.0181
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0926 0.1248
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0579 0.363
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.016 0.0481
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.016 0.051
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0059 0.0058
Mycobacterium ulcerans pyruvate kinase 0.004 0.0199 0.0356
Trypanosoma cruzi heat shock protein 90, putative 0.0035 0.016 0.051
Trypanosoma cruzi heat shock protein, putative 0.0014 0.0016 0.0031
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0026 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.018
Leishmania major DNA polymerase eta, putative 0.0021 0.0061 0.018
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0061 0.0081
Leishmania major heat shock protein, putative 0.0014 0.0016 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0084 0.028
Plasmodium falciparum heat shock protein 90, putative 0.0014 0.0016 0.0031
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0061 0.006
Trypanosoma brucei protein kinase, putative 0.0056 0.0306 0.0996
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0084 0.0281
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0061 0.018
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0199 0.0639
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0061 0.01
Schistosoma mansoni lipoxygenase 0.0057 0.0315 0.0314
Schistosoma mansoni pyruvate kinase 0.0021 0.0061 0.0061
Loa Loa (eye worm) heat shock protein 90 0.0035 0.016 0.0215
Schistosoma mansoni hypothetical protein 0.0035 0.0165 0.0164
Echinococcus granulosus pyruvate kinase 0.004 0.0199 0.0198
Schistosoma mansoni pyruvate kinase 0.004 0.0199 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0021 0.0069
Plasmodium vivax endoplasmin, putative 0.0035 0.016 0.051
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0026 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0012 0.0041
Trypanosoma cruzi Heat shock protein 83, putative 0.0035 0.016 0.051
Brugia malayi hypothetical protein 0.0035 0.0165 0.0222
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0512 0.1353
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0194 0.1274 0.1718
Loa Loa (eye worm) hypoxia-induced factor 1 0.0179 0.1169 0.1576
Echinococcus multilocularis tar DNA binding protein 0.0131 0.0833 0.0833
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0147 0.0491
Plasmodium falciparum eukaryotic initiation factor 4A 0.0441 0.3004 1
Echinococcus multilocularis tumor protein p63 0.0343 0.2316 0.2315
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.018
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0118 0.0393
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0306 0.0996
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0052 0.015
Mycobacterium leprae putative cytochrome p450 0.003 0.0126 0.0677
Trypanosoma brucei Heat shock protein 83, putative 0.0035 0.016 0.051
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.0022 0.0021
Plasmodium vivax heat shock protein 86, putative 0.0035 0.016 0.051
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0052 0.0121
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0234 0.1556 0.1556
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0154 0.0513
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0059 0.0172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0084 0.0281
Schistosoma mansoni polycystin 1-related 0.002 0.0059 0.0058
Trichomonas vaginalis adenylate cyclase, putative 0.0015 0.0022 0.0073
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0512 0.1353
Echinococcus granulosus lysine specific histone demethylase 1A 0.0991 0.6849 0.6849
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0061 0.01
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.003 0.0126 0.0221
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0306 0.0996
Loa Loa (eye worm) hypothetical protein 0.0991 0.6849 0.9242
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.003 0.0126 0.0317
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0441 0.3004 0.4053
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.003 0.0126 0.0221
Brugia malayi isocitrate dehydrogenase 0.0016 0.0026 0.0034
Echinococcus multilocularis endoplasmin 0.0028 0.011 0.011
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0022 0.0073
Onchocerca volvulus 0.0033 0.015 0.0202
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0026 0.0062
Plasmodium vivax hypothetical protein, conserved 0.0234 0.1556 0.5169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0164 0.0544
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0164 0.0522
Loa Loa (eye worm) RNA binding protein 0.0131 0.0833 0.1123
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0016 0.003
Schistosoma mansoni lipoxygenase 0.002 0.0059 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0147 0.0491
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0052 0.0052
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0028 0.011 0.0344
Brugia malayi heat shock protein 90 0.0035 0.016 0.0215
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0234 0.1556 0.5169
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0931 0.3084
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0199 0.0267
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0234 0.1556 1
Loa Loa (eye worm) cytochrome P450 0.003 0.0126 0.0169
Trypanosoma brucei pyruvate kinase 1 0.004 0.0199 0.0639
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0441 0.3004 1
Brugia malayi RNA binding protein 0.0131 0.0833 0.1123
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0061 0.0204
Schistosoma mansoni hypothetical protein 0.0016 0.0026 0.0025
Brugia malayi eukaryotic initiation factor 4A 0.0441 0.3004 0.4053
Entamoeba histolytica SWIRM domain protein 0.008 0.0479 0.1547
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0164 0.0522
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0059 0.0058
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.016 0.0481
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.003 0.0126 0.0317
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0022 0.0071 0.0414
Brugia malayi glutathione reductase 0.0037 0.0178 0.0239
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0061 0.006
Trichomonas vaginalis helicase, putative 0.0014 0.0012 0.0041
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0025 0.0061
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0012 0.0002 0.0002
Brugia malayi Hsp90 protein 0.0014 0.0016 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0102 0.034
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0306 0.0305
Giardia lamblia Grp94/Hsp90 0.0028 0.011 0.0344
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0014 0.0016 0.0016
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0061 0.018
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0441 0.3004 0.3004
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.0022 0.0021
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0022 0.0073
Mycobacterium tuberculosis Possible oxidoreductase 0.0234 0.1556 0.4148
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0441 0.3004 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0199 0.0267
Toxoplasma gondii exonuclease III APE 0.0019 0.0052 0.015
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0199 0.0639
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.018
Schistosoma mansoni ap endonuclease 0.0019 0.0052 0.0052
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0052 0.0084
Mycobacterium tuberculosis Possible oxidoreductase 0.0081 0.0484 0.1277
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0149 0.0472
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0028 0.011 0.2163
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0227 0.0733
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0441 0.3004 0.3004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0081
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0016 0.0015
Schistosoma mansoni hypothetical protein 0.0014 0.0016 0.0015
Onchocerca volvulus 0.0267 0.1783 0.2404
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0012 0.0041
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0052 0.015
Trypanosoma brucei unspecified product 0.0014 0.0016 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0022 0.0073
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.003 0.0126 0.0317
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.003 0.0126 0.0317
Giardia lamblia DINP protein human, muc B family 0.0021 0.0061 0.018
Trypanosoma brucei heat shock protein, putative 0.0035 0.016 0.051
Loa Loa (eye worm) CYP4Cod1 0.0058 0.0323 0.0434
Leishmania major cytochrome p450-like protein 0.003 0.0126 0.0396
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0059 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0021 0.0069
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0303 0.0408
Mycobacterium ulcerans oxidoreductase 0.0081 0.0484 0.0888
Trichomonas vaginalis rotamase, putative 0.0033 0.0149 0.0495
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.003 0.0126 0.0221
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0218 0.1441 0.144
Mycobacterium ulcerans hypothetical protein 0.0081 0.0484 0.0888
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0306 0.0996
Echinococcus granulosus heat shock protein 0.0035 0.016 0.0159
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0234 0.1556 0.2882
Schistosoma mansoni heat shock protein 0.0014 0.0016 0.0016
Giardia lamblia Pyruvate kinase 0.004 0.0199 0.0639
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0164 0.0522
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0441 0.3004 1
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0441 0.3004 1
Mycobacterium ulcerans dehydrogenase 0.0234 0.1556 0.2882
Echinococcus multilocularis 0.0234 0.1556 0.1556
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0182 0.0605
Brugia malayi Cytochrome P450 family protein 0.011 0.0687 0.0926
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0165 0.0164
Brugia malayi Cytochrome P450 family protein 0.0058 0.0323 0.0434
Echinococcus granulosus heat shock protein 90 0.0035 0.016 0.0159
Echinococcus granulosus tumor protein p63 0.0343 0.2316 0.2315
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0234 0.1556 0.5169
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0012 0.0041
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.1489 0.2009
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.0484 0.1592
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0026 0.0062
Entamoeba histolytica hypothetical protein 0.008 0.0479 0.1547
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.003 0.0126 0.0317
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0227 0.0305
Trichomonas vaginalis heat shock protein, putative 0.0014 0.0016 0.0055
Loa Loa (eye worm) cytochrome P450 family protein 0.011 0.0687 0.0926
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0081 0.0484 0.0653
Onchocerca volvulus 0.006 0.0339 0.0456
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0061 0.018
Brugia malayi Death domain containing protein 0.0014 0.0016 0.002
Schistosoma mansoni cpg binding protein 0.0064 0.0363 0.0362
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0199 0.0267
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0026 0.0025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0303 0.0303
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0303 0.0303
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0021 0.002
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0833 0.0833
Trichomonas vaginalis heat shock protein, putative 0.0035 0.016 0.0533
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0022 0.0073
Trypanosoma brucei trypanothione reductase 0.0037 0.0178 0.0569
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0016 0.002
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0052 0.0069
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0512 0.1353
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.018
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0216 0.0389
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0052 0.015
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0833 0.0833
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0059 0.0172
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.008 0.0479 0.0478
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0016 0.0015
Plasmodium falciparum protoporphyrinogen oxidase 0.0234 0.1556 0.5169
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0022 0.0073
Echinococcus multilocularis RUN 0.002 0.0059 0.0058
Schistosoma mansoni heat shock protein 0.0035 0.016 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0125 0.0416
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0154 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0012 0.0041
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0025 0.0061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0303 0.0303
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0084 0.0281
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.003 0.0126 0.0317
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0991 0.6849 0.9242
Mycobacterium ulcerans oxidoreductase 0.0234 0.1556 0.2882
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.003 0.0126 0.0221
Giardia lamblia GTOR 0.0044 0.0227 0.0733
Plasmodium falciparum heat shock protein 90, putative 0.0014 0.0016 0.0031
Leishmania major DNA polymerase kappa, putative 0.0021 0.0061 0.018
Brugia malayi Protein kinase domain containing protein 0.0015 0.0019 0.0025
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0084 0.028
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0025 0.0061
Leishmania major hypothetical protein, conserved 0.0081 0.0484 0.1592
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0441 0.3004 0.3004
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.0113 0.0324
Chlamydia trachomatis monooxygenase 0.0081 0.0484 0.308
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0061 0.018
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.003 0.0126 0.0221
Echinococcus granulosus dna polymerase kappa 0.0021 0.0061 0.006
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0238 0.1582 0.5255
Echinococcus multilocularis protein MICAL 3 0.0081 0.0484 0.0484
Mycobacterium tuberculosis Conserved hypothetical protein 0.0234 0.1556 0.4148
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0178 0.0569
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.01 0.0334
Echinococcus granulosus protein MICAL 3 0.0081 0.0484 0.0484
Schistosoma mansoni DNA polymerase eta 0.0021 0.0061 0.006
Loa Loa (eye worm) hypothetical protein 0.008 0.0479 0.0645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0102 0.034
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Entamoeba histolytica hypothetical protein 0.0035 0.0165 0.0497
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0026 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0147 0.0491
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.2061 0.6852
Brugia malayi hypothetical protein 0.002 0.0059 0.0078
Mycobacterium ulcerans hypothetical protein 0.0081 0.0484 0.0888
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0306 0.1018
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0061 0.0081
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0512 0.1353
Trypanosoma brucei cytochrome P450, putative 0.0058 0.0323 0.1052
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0579 0.1531
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0154 0.0207
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0052 0.015
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0016 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.015 0.0149
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0306 0.0996
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0054 0.0072
Echinococcus granulosus pyruvate kinase 0.0021 0.0061 0.0061
Trypanosoma brucei unspecified product 0.0014 0.0016 0.003
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0833 0.0833
Mycobacterium ulcerans oxidoreductase GMC-type 0.0081 0.0484 0.0888
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0227 0.0733
Trichomonas vaginalis heat shock protein, putative 0.0028 0.011 0.0368
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0261 0.0351
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0227 0.0733
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0015 0.0022 0.0073
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0026 0.0025
Toxoplasma gondii FAD binding domain-containing protein 0.0081 0.0484 0.1592
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0028 0.011 0.011
Schistosoma mansoni loxhd1 0.002 0.0059 0.0058
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0315 0.0314
Schistosoma mansoni rab6-interacting 0.002 0.0059 0.0058
Trichomonas vaginalis heat shock protein, putative 0.0028 0.011 0.0368
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Toxoplasma gondii cytochrome p450 superfamily protein 0.003 0.0126 0.0396
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0046 0.0128
Trypanosoma brucei heat shock protein, putative 0.0035 0.016 0.051
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0052 0.0944
Trypanosoma cruzi cytochrome P450, putative 0.0058 0.0323 0.1052
Leishmania major pyruvate kinase 0.004 0.0199 0.0639
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0833 0.0833
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0016 0.0015
Echinococcus multilocularis geminin 0.0348 0.2354 0.2353
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.003 0.0029
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0061 0.0081
Echinococcus granulosus nuclear factor of activated T cells 5 0.0218 0.1441 0.144
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.003 0.0126 0.0317
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0218 0.0704
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0026 0.0034
Mycobacterium tuberculosis Possible oxidoreductase 0.0081 0.0484 0.1277
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0199 0.1152
Treponema pallidum heat shock protein 90 0.0028 0.011 0.0344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0084 0.028
Toxoplasma gondii pyruvate kinase PyKII 0.0021 0.0061 0.0181
Giardia lamblia hypothetical protein 0.008 0.0479 0.1573
Plasmodium vivax heat shock protein, putative 0.0014 0.0016 0.0031
Brugia malayi hypothetical protein 0.002 0.0059 0.0078
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0149 0.0472
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0012 0.0041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0012 0.0041
Schistosoma mansoni hypothetical protein 0.003 0.0126 0.0125
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.003 0.0126 0.0396
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0284 0.0924
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.003 0.0126 0.0317
Echinococcus multilocularis protoporphyrinogen oxidase 0.0234 0.1556 0.1556
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.003 0.0126 0.0396
Mycobacterium ulcerans hypothetical protein 0.0081 0.0484 0.0888
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0227 0.0733
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0059 0.0058
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0026 0.0062
Brugia malayi MAP kinase sur-1 0.0056 0.0306 0.0411
Onchocerca volvulus 0.005 0.0268 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0227 0.0756
Trypanosoma brucei heat shock protein, putative 0.0035 0.016 0.051
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0012 0.0041
Mycobacterium ulcerans hypothetical protein 0.0161 0.1046 0.1933
Entamoeba histolytica hypothetical protein 0.0035 0.0165 0.0497
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0441 0.3004 1
Entamoeba histolytica SWIRM domain protein 0.008 0.0479 0.1547
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.003 0.0126 0.0317
Brugia malayi Cytochrome P450 family protein 0.0058 0.0323 0.0434
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.003 0.0126 0.0221
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.0931 0.3084
Toxoplasma gondii SWIRM domain-containing protein 0.008 0.0479 0.1573
Giardia lamblia Heat shock protein HSP 90-alpha 0.0028 0.011 0.0344
Schistosoma mansoni single-minded 0.0058 0.0321 0.032
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.003 0.0126 0.0221
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0066 0.022
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0007 0.0024
Echinococcus granulosus Ankyrin 0.0014 0.0017 0.0016
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.003 0.0029
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0021 0.002
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0152 0.0204
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0026 0.0034
Echinococcus multilocularis cpg binding protein 0.0064 0.0363 0.0362
Brugia malayi CXXC zinc finger family protein 0.006 0.0339 0.0456
Brugia malayi Doublecortin family protein 0.002 0.0059 0.0078
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.003 0.0029
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.003 0.0126 0.0317
Treponema pallidum ATP-dependent RNA helicase 0.0441 0.3004 1
Trichomonas vaginalis heat shock protein, putative 0.0028 0.011 0.0368
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0165 0.0164
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.015 0.0149
Loa Loa (eye worm) hypothetical protein 0.0234 0.1556 0.2099
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0199 0.0267
Loa Loa (eye worm) hypothetical protein 0.0028 0.0113 0.0152
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0052 0.015
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0026 0.0034
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0021 0.0027
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0323 0.0434
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0315 0.0314
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0061 0.018
Brugia malayi hypoxia-induced factor 1 0.0179 0.1169 0.1576
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0303 0.0408
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0061 0.018
Plasmodium vivax SET domain protein, putative 0.0033 0.015 0.0477
Echinococcus multilocularis Ankyrin 0.0014 0.0017 0.0016
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0991 0.6849 0.6849
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0026 0.0034
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.016 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0164 0.0544
Plasmodium vivax pyruvate kinase 2, putative 0.0021 0.0061 0.0181
Schistosoma mansoni SWI/SNF complex-related 0.008 0.0479 0.0478
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0199 0.0267
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0056 0.0055
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0056 0.0055
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0022 0.0073
Echinococcus multilocularis dna polymerase eta 0.0021 0.0061 0.006
Schistosoma mansoni netrin receptor unc5 0.0014 0.0016 0.0015
Toxoplasma gondii heat shock protein 90, putative 0.0035 0.016 0.051
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0025
Trypanosoma cruzi UDP-galactopyranose mutase 0.0234 0.1556 0.5169
Trichomonas vaginalis set domain proteins, putative 0.0256 0.1705 0.5677
Brugia malayi PAS domain containing protein 0.0058 0.0321 0.0432
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.0833 0.1123
Schistosoma mansoni rab6-interacting 0.002 0.0059 0.0058
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0021 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0022 0.0073
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0926 0.1248
Plasmodium falciparum thioredoxin reductase 0.0037 0.0178 0.0569
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0028 0.011 0.0276
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0052 0.015
Wolbachia endosymbiont of Brugia malayi 2-polyprenyl-6-methoxyphenol 4-hydroxylase 0.0081 0.0484 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.003 0.0126 0.0317
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.018
Echinococcus granulosus ubiquinone biosynthesis monooxygenase COQ6 0.0081 0.0484 0.0484
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0021 0.002
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0026 0.0025
Schistosoma mansoni hypothetical protein 0.0016 0.0026 0.0025
Echinococcus multilocularis pyruvate kinase 0.0021 0.0061 0.0061
Echinococcus granulosus endoplasmin 0.0028 0.011 0.011
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0021 0.0045
Schistosoma mansoni monoxygenase 0.0081 0.0484 0.0484
Schistosoma mansoni amine oxidase 0.0234 0.1556 0.1556
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.003 0.0126 0.0317
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0028 0.011 0.0577
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0063 0.0188
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.003 0.0126 0.0317
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0061 0.018
Echinococcus multilocularis pyruvate kinase 0.0032 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0149 0.096 0.1294
Trichomonas vaginalis endoplasmin, putative 0.0021 0.0066 0.022
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0059 0.0058
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0147 0.0468
Brugia malayi hypothetical protein 0.0194 0.1274 0.1718
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0306 0.0996
Echinococcus multilocularis heat shock protein 0.0035 0.016 0.0159
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Plasmodium vivax heat shock protein 90, putative 0.0014 0.0016 0.0031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0303 0.0303
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0178 0.0239
Plasmodium vivax pyruvate kinase, putative 0.004 0.0199 0.0639
Echinococcus granulosus pyruvate kinase 0.004 0.0199 0.0198
Echinococcus multilocularis dnaJ subfamily B 0.0421 0.2864 0.2864
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.2061 0.6852
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0234 0.1556 0.5169
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0052 0.012
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0199 0.0661
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0012 0.0041
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0306 0.0411
Onchocerca volvulus 0.1071 0.7411 1
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0441 0.3004 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0114 0.0152
Onchocerca volvulus 0.002 0.0059 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0012 0.0041
Echinococcus granulosus heat shock protein 90 0.0028 0.011 0.011
Mycobacterium ulcerans FAD-dependent oxidoreductase 0.0081 0.0484 0.0888
Trypanosoma brucei heat shock protein 84, putative 0.0014 0.0016 0.0031
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0547 0.3742 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0147 0.0491
Trypanosoma brucei heat shock protein, putative 0.0035 0.016 0.051
Brugia malayi hypothetical protein 0.0234 0.1556 0.2099
Onchocerca volvulus 0.0149 0.096 0.1294
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0306 0.0305
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0015 0.0022 0.0073
Mycobacterium leprae Conserved hypothetical protein 0.003 0.0126 0.0677
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0165 0.0164
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0007 0.0006
Echinococcus multilocularis 0.003 0.0126 0.0125
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.015 0.0149
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.003 0.0126 0.0221
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.003 0.0126 0.0317
Trypanosoma brucei heat shock protein, putative 0.0035 0.016 0.051
Giardia lamblia Pyruvate kinase 0.0021 0.0061 0.0181
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0149 0.0443
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.003 0.0126 0.0317
Trypanosoma brucei heat shock protein, putative 0.0035 0.016 0.051
Echinococcus multilocularis heat shock protein 90 0.0035 0.016 0.0159
Mycobacterium tuberculosis Probable oxidoreductase 0.0081 0.0484 0.1277
Onchocerca volvulus 0.002 0.0059 0.0078
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0781 0.5382 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0022 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0061 0.018
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0007 0.0006
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0015 0.0022 0.0028
Schistosoma mansoni endoplasmin 0.0035 0.016 0.0159
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.016 0.051
Loa Loa (eye worm) pyruvate kinase 0.004 0.0199 0.0267
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0306 0.0996
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.003 0.0126 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.01 0.0334
Echinococcus granulosus pyruvate kinase 0.0021 0.0061 0.0061
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.003 0.0126 0.0221
Trypanosoma cruzi Monooxygenase, putative 0.0081 0.0484 0.1592
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.003 0.0029
Schistosoma mansoni pyruvate kinase 0.004 0.0199 0.0198
Toxoplasma gondii heat shock protein 75, putative 0.0014 0.0016 0.0031
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0227 0.0705
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0026 0.0062
Plasmodium vivax RNA helicase-1, putative 0.0441 0.3004 1
Loa Loa (eye worm) histone methyltransferase 0.002 0.0056 0.0074
Trypanosoma cruzi heat shock protein 90, putative 0.0021 0.006 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0084 0.0281
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0059 0.0058
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0306 0.0305
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0833 0.0833
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0306 0.1018
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.003 0.0126 0.0317
Schistosoma mansoni hypothetical protein 0.002 0.0059 0.0058
Mycobacterium tuberculosis Possible oxidoreductase 0.0081 0.0484 0.1277
Schistosoma mansoni cpg binding protein 0.0064 0.0363 0.0362
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0012 0.0041
Mycobacterium ulcerans FAD-linked oxidoreductase 0.0081 0.0484 0.0888
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.016 0.051
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0227 0.0733
Echinococcus multilocularis GPCR, family 2 0.0016 0.0026 0.0025
Brugia malayi Thioredoxin reductase 0.0037 0.0178 0.0239
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Schistosoma mansoni hypothetical protein 0.0348 0.2354 0.2353
Entamoeba histolytica hypothetical protein 0.0035 0.0165 0.0497
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0061 0.006
Loa Loa (eye worm) glutathione reductase 0.0037 0.0178 0.0239
Echinococcus granulosus RUN 0.002 0.0059 0.0058
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0022 0.0049
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.003 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0022 0.0073
Toxoplasma gondii histone lysine-specific demethylase 0.0234 0.1556 0.5169
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0227 0.0705
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0016 0.0015
Trypanosoma cruzi heat shock protein 85, putative 0.0028 0.011 0.0344
Mycobacterium ulcerans membrane-associated oxidoreductase 0.0081 0.0484 0.0888
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0021 0.0045
Echinococcus multilocularis pyruvate kinase 0.004 0.0199 0.0198
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0227 0.0226
Leishmania major eukaryotic initiation factor 4a, putative 0.0441 0.3004 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0012 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0016 0.003
Schistosoma mansoni amine oxidase 0.0234 0.1556 0.1556
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.003 0.0126 0.0317
Mycobacterium leprae possibleputative FAD-linked oxidoreductase 0.0081 0.0484 0.3014
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0061 0.0204
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.003 0.0126 0.0221
Loa Loa (eye worm) hypothetical protein 0.0315 0.2118 0.2857
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0178 0.0457
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.003 0.0126 0.0317
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0061 0.0144
Leishmania major hypothetical protein, conserved 0.0081 0.0484 0.1592
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0007 0.0024
Plasmodium vivax FAD-dependent monooxygenase, putative 0.0081 0.0484 0.1592
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0216 0.0215
Onchocerca volvulus 0.0256 0.1706 0.2302
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0026 0.0025
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.003 0.0126 0.0221
Echinococcus granulosus expressed protein 0.0034 0.0154 0.0153
Leishmania major UDP-galactopyranose mutase 0.0234 0.1556 0.5169
Leishmania major protein kinase, putative 0.0016 0.0025 0.0061
Schistosoma mansoni heat shock protein 0.0035 0.016 0.0159
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0306 0.0305
Echinococcus granulosus single minded 2 0.0043 0.0216 0.0215
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0052 0.0052
Onchocerca volvulus 0.0043 0.0216 0.0291
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0021 0.0027
Loa Loa (eye worm) hypothetical protein 0.002 0.0059 0.0078
Schistosoma mansoni hypothetical protein 0.0081 0.0484 0.0484
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.003 0.0126 0.0317
Schistosoma mansoni hypothetical protein 0.0016 0.0026 0.0025
Mycobacterium ulcerans monoamine oxidase 0.0234 0.1556 0.2882
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0021 0.0069
Brugia malayi cytochrome P450 0.003 0.0126 0.0169
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0199 0.0661
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0012 0.0041
Schistosoma mansoni hypothetical protein 0.0034 0.0152 0.0151
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0579 0.1531
Loa Loa (eye worm) hypothetical protein 0.0441 0.3004 0.4053
Brugia malayi Pax transcription factor protein 2 0.0267 0.1783 0.2404
Mycobacterium tuberculosis Probable reductase 0.0085 0.0512 0.1353
Brugia malayi MH2 domain containing protein 0.0144 0.0926 0.1248
Echinococcus granulosus dnaJ subfamily B 0.0421 0.2864 0.2864
Echinococcus multilocularis pyruvate kinase 0.0021 0.0061 0.0061
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.082 0.0819
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0028
Loa Loa (eye worm) hypothetical protein 0.0034 0.0152 0.0204
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0149 0.0472
Brugia malayi Cytochrome P450 family protein 0.003 0.0126 0.0169
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0234 0.1556 0.2099
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0199 0.0639
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0199 0.0267
Loa Loa (eye worm) hypothetical protein 0.005 0.0268 0.036
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0227 0.0305
Echinococcus granulosus pyruvate kinase 0.0021 0.0061 0.0061
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.003 0.0126 0.0221
Loa Loa (eye worm) pax transcription factor protein 2 0.0267 0.1783 0.2404
Echinococcus multilocularis heat shock protein 90 0.0028 0.011 0.011
Loa Loa (eye worm) heat shock protein 75 0.0014 0.0016 0.0021
Schistosoma mansoni endoplasmin 0.0035 0.016 0.0159
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0026 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.018
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0199 0.0639
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0216 0.0291
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0149 0.0472
Mycobacterium ulcerans oxidoreductase 0.0081 0.0484 0.0888
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0261 0.0351
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0016 0.003
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.003 0.0126 0.0317
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0323 0.0434
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.003 0.0126 0.0221
Leishmania major cytochrome p450-like protein 0.0058 0.0323 0.1052
Loa Loa (eye worm) doublecortin family protein 0.002 0.0059 0.0078
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0133 0.0132
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0227 0.0733
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0164 0.0544
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.003 0.0126 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0147 0.0491
Echinococcus granulosus cytochrome P450 2K1 0.003 0.0126 0.0125
Brugia malayi Pre-SET motif family protein 0.0033 0.015 0.0202
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0441 0.3004 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0021 0.0069
Leishmania major cytochrome p450-like protein 0.003 0.0126 0.0396
Plasmodium falciparum FAD-dependent monooxygenase, putative 0.0081 0.0484 0.1592
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0012 0.0041
Trypanosoma brucei Monooxygenase, putative 0.0081 0.0484 0.1592
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0022 0.0049
Schistosoma mansoni aryl hydrocarbon receptor 0.0058 0.0321 0.032
Echinococcus multilocularis pyruvate kinase 0.0021 0.0061 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.018
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.016 0.051
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.008 0.0479 0.0478
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0061 0.0144
Giardia lamblia Heat shock protein HSP 90-alpha 0.0035 0.016 0.051
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0218 0.0704
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.015 0.0149
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0724 0.2392
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0306 0.0305
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.015 0.0149
Loa Loa (eye worm) hypothetical protein 0.0049 0.0261 0.0351
Plasmodium falciparum glutathione reductase 0.0037 0.0178 0.0569
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.018
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0025
Trichomonas vaginalis rotamase, putative 0.0034 0.0154 0.0513
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0007 0.0006
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0052 0.0174
Loa Loa (eye worm) endoplasmin 0.0035 0.016 0.0215
Plasmodium vivax glutathione reductase, putative 0.0037 0.0178 0.0569
Schistosoma mansoni rotamase 0.0034 0.0154 0.0153
Toxoplasma gondii Hsp90 domain-containing protein 0.0014 0.0016 0.0031
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0026 0.0062
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0026 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0164 0.0544
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0021 0.0045
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0052 0.015
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.015 0.0149
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0931 0.3084
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0058 0.0323 0.0587
Brugia malayi hypothetical protein 0.0149 0.096 0.1294
Loa Loa (eye worm) hypothetical protein 0.0033 0.015 0.0202
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0021 0.0045
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0512 0.3197
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0025
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.015 0.0149
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0014 0.0016 0.0021
Trypanosoma brucei heat shock protein, putative 0.0035 0.016 0.051
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0052 0.0069
Loa Loa (eye worm) hypothetical protein 0.002 0.0059 0.0078
Brugia malayi SWIRM domain containing protein 0.008 0.0479 0.0645
Loa Loa (eye worm) pyruvate kinase 0.004 0.0199 0.0267
Mycobacterium tuberculosis Probable oxidoreductase 0.0081 0.0484 0.1277
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.003 0.0126 0.0221
Trypanosoma brucei unspecified product 0.0021 0.0061 0.018
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0441 0.3004 0.3004
Onchocerca volvulus 0.0015 0.0022 0.0028

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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