Detailed information for compound 1412496

Basic information

Technical information
  • TDR Targets ID: 1412496
  • Name: 3-[(3-amino-5-sulfanylidene-1H-1,2,4-triazol- 4-yl)amino]indol-2-one
  • MW: 260.275 | Formula: C10H8N6OS
  • H donors: 2 H acceptors: 3 LogP: 0.63 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1Nc2c(C1=Nn1c(N)nnc1S)cccc2
  • InChi: 1S/C10H8N6OS/c11-9-13-14-10(18)16(9)15-7-5-3-1-2-4-6(5)12-8(7)17/h1-4H,(H2,11,13)(H,14,18)(H,12,15,17)
  • InChiKey: PRKCMWUATRLCBA-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3-[(3-amino-5-thioxo-1H-1,2,4-triazol-4-yl)amino]indol-2-one
  • 3-[(3-amino-5-thioxo-1H-1,2,4-triazol-4-yl)amino]-2-indolone
  • Oprea1_455809
  • ZINC01957838
  • ZINC01957840
  • 3-[(3-amino-5-sulfanyl-4H-1,2,4-triazol-4-yl)imino]-1,3-dihydro-2H-indol-2-one
  • MLS000548180
  • SMR000114465

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens regulator of G-protein signaling 4 Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens mannose phosphate isomerase Starlite/ChEMBL No references
Trypanosoma brucei hypothetical protein, conserved Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Simian virus 40 Large T antigen Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO Get druggable targets OG5_127555 All targets in OG5_127555
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi DnaJ domain containing protein Get druggable targets OG5_132364 All targets in OG5_132364
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni mannose-6-phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania braziliensis phosphomannose isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Cryptosporidium parvum mannose-6-phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania donovani phosphomannose isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus dnaJ subfamily C 6 Get druggable targets OG5_132364 All targets in OG5_132364
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni hypothetical protein Get druggable targets OG5_132364 All targets in OG5_132364
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Candida albicans hypothetical protein Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium yoelii Phosphomannose isomerase type I, putative Get druggable targets OG5_127555 All targets in OG5_127555
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum phosphomannose isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi mannose-6-phosphate isomerase, class I family protein Get druggable targets OG5_127555 All targets in OG5_127555
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA Get druggable targets OG5_127555 All targets in OG5_127555
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Babesia bovis phosphomannose isomerase type I family protein Get druggable targets OG5_127555 All targets in OG5_127555
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho Get druggable targets OG5_127555 All targets in OG5_127555
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Candida albicans mannose-6-phosphate isomerase capable of functionally substituting for S. cerevisiae PMI40 (YER003C) Get druggable targets OG5_127555 All targets in OG5_127555
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium ulcerans 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi mannose-6-phosphate isomerase, class I family protein Get druggable targets OG5_127555 All targets in OG5_127555
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum expressed protein Get druggable targets OG5_132364 All targets in OG5_132364
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) mannose-6-phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii phosphomannose isomerase type I protein Get druggable targets OG5_127555 All targets in OG5_127555
Plasmodium vivax mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis mannose 6 phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127555 All targets in OG5_127555
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_127555 All targets in OG5_127555
Trichomonas vaginalis protein kinase inhibitor, putative Get druggable targets OG5_132364 All targets in OG5_132364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania donovani ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma congolense phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K09536 DnaJ homolog, subfamily C, member 16, putative Get druggable targets OG5_132364 All targets in OG5_132364
Trypanosoma brucei phosphomannose isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Echinococcus granulosus mannose 6 phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 6-phospho-1-fructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) DnaJ domain-containing protein Get druggable targets OG5_132364 All targets in OG5_132364
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania infantum ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Plasmodium falciparum mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Trypanosoma congolense ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans mannose-6-phosphate isomerase capable of functionally substituting for S. cerevisiae PMI40 (YER003C) Get druggable targets OG5_127555 All targets in OG5_127555
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium berghei mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Schistosoma japonicum ko:K01809 mannose-6-phosphate isomerase [EC5.3.1.8], putative Get druggable targets OG5_127555 All targets in OG5_127555
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major phosphomannose isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Echinococcus multilocularis dnaJ subfamily C 6 Get druggable targets OG5_132364 All targets in OG5_132364
Leishmania mexicana phosphomannose isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) mannose-6-phosphate isomerase Get druggable targets OG5_127555 All targets in OG5_127555
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) Get druggable targets OG5_126758 All targets in OG5_126758
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania major ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Theileria parva mannose-6-phosphate isomerase, putative Get druggable targets OG5_127555 All targets in OG5_127555
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) DnaJ domain-containing protein 0.0074 0.0136 0.0374
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0793 0.2184
Onchocerca volvulus 0.0029 0.0029 0.0192
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.008
Loa Loa (eye worm) histone deacetylase 7A 0.1307 0.3039 0.8377
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0033
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0048 0.0075 0.0178
Schistosoma mansoni brca1-associated protein (brap2) 0.0083 0.0157 0.0404
Echinococcus multilocularis carbonic anhydrase 0.029 0.0645 0.1755
Schistosoma mansoni histone deacetylase hda2 0.0659 0.1513 0.4153
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0083 0.0157 0.0404
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0028 0.0078
Trypanosoma cruzi UDP-galactose 4-epimerase, putative 0.0054 0.0089 0.0245
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0134 0.0122
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0048 0.0105
Brugia malayi jmjC domain containing protein 0.0186 0.04 0.1103
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0045 1
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0045 0.0125
Trypanosoma cruzi histone deacetylase 1, putative 0.1558 0.3628 1
Toxoplasma gondii histone deacetylase HDAC1 0.1307 0.3039 0.8373
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.0016 0.0045
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0083 0.0157 0.0404
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0045 0.0095
Echinococcus multilocularis expressed protein 0.0451 0.1023 0.2799
Echinococcus granulosus chromobox protein 1 0.0084 0.016 0.0413
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0083 0.0157 0.0432
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.1923 0.5288
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.0016 0.0016
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0016 0.0045
Loa Loa (eye worm) hypothetical protein 0.1558 0.3628 1
Plasmodium falciparum histone deacetylase 2 0.1307 0.3039 0.8373
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0083 0.0201
Schistosoma mansoni hypothetical protein 0.0074 0.0136 0.0347
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0033
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB 0.0048 0.0075 0.0063
Schistosoma mansoni cpg binding protein 0.007 0.0126 0.0319
Echinococcus granulosus histone deacetylase 3 0.1558 0.3628 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0134 0.0343
Echinococcus granulosus citrate lyase subunit beta protein 0.003 0.0031 0.0058
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0016 0.0016
Schistosoma mansoni cpg binding protein 0.0072 0.013 0.0332
Echinococcus granulosus histone deacetylase 6 0.1307 0.3039 0.8373
Plasmodium vivax JmjC domain containing protein 0.003 0.0033 0.0063
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0083 0.0157 0.0432
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0083 0.0157 0.0432
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0016 0.0016
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0083 0.0157 0.0404
Plasmodium vivax histone deacetylase 2, putative 0.1307 0.3039 0.8373
Schistosoma mansoni alpha glucosidase 0.0044 0.0064 0.015
Mycobacterium tuberculosis Conserved hypothetical protein 0.0048 0.0075 0.0066
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0064 0.015
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0487 0.1108 0.3055
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0134 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0016 0.0045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0793 0.2184
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.1124 0.308
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0048 0.0105
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0134 0.0127
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.0016 0.0016
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0016 0.0016
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0368 0.034
Schistosoma mansoni histone deacetylase 0.1558 0.3628 1
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0083 0.0157 0.0432
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0083 0.0157 0.0432
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0083 0.0157 0.0432
Trichomonas vaginalis chromobox protein, putative 0.0084 0.016 0.044
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0117 0.0238 0.0226
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0083 0.0157 0.0432
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0033 0.0091
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.029 0.0645 0.1779
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0138 0.0353
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0048 0.0075 0.0178
Onchocerca volvulus 0.0051 0.0081 0.0534
Brugia malayi hypothetical protein 0.0023 0.0016 0.0045
Onchocerca volvulus 0.01 0.0198 0.1309
Loa Loa (eye worm) hypothetical protein 0.0047 0.0073 0.02
Echinococcus multilocularis peregrin 0.0039 0.0055 0.0123
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0048 0.0075 0.0084
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.0017
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0048 0.0075 0.0206
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0013 0.0035
Leishmania major hypothetical protein, conserved 0.003 0.0033 0.0091
Trichomonas vaginalis histone deacetylase, putative 0.1558 0.3628 1
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0117 0.0238 0.0656
Onchocerca volvulus 0.0037 0.0049 0.0322
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0028 0.0049
Schistosoma mansoni brca1-associated protein (brap2) 0.0083 0.0157 0.0404
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0271 0.0746
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0134 0.0343
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0028 0.0016
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0016 0.0016
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0083 0.0157 0.0404
Toxoplasma gondii phosphomannose isomerase type I protein 0.0117 0.0238 0.063
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0083 0.0157 0.0432
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0028 0.0019
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0048 0.0105
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0271 0.0746
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0271 0.0746
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.029 0.0645 0.1779
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0048 0.0075 0.0206
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0064 0.0178
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0083 0.0157 0.0432
Entamoeba histolytica hypothetical protein 0.0023 0.0016 0.0045
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.0271 0.0746
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0487 0.1108 0.3055
Loa Loa (eye worm) hypothetical protein 0.0649 0.1488 0.4102
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.0425 0.1146
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0793 0.2184
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0083 0.0157 0.0404
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0028 0.0049
Entamoeba histolytica histone deacetylase, putative 0.1558 0.3628 1
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0566 0.1561
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0083 0.0157 0.0432
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0016 0.0045
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0083 0.0157 0.0404
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0013 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0016 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0016 0.0016
Echinococcus granulosus disco interacting protein 2 0.0041 0.0059 0.0135
Trypanosoma brucei histone deacetylase 3 0.1307 0.3039 0.8377
Brugia malayi Disco-interacting protein 2 homolog 0.004 0.0056 0.0156
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0045
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.0016 0.0016
Schistosoma mansoni histone deacetylase 0.1558 0.3628 1
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0117 0.0238 0.0656
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0016 0.0016
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0487 0.1108 0.3055
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.0425 0.1171
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0013 0.0035
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0045 0.0096
Mycobacterium tuberculosis Conserved protein 0.003 0.0031 0.0022
Trichomonas vaginalis histone deacetylase, putative 0.1558 0.3628 1
Brugia malayi 6-phosphofructokinase 0.0131 0.0271 0.0746
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0064 0.0178
Toxoplasma gondii histone deacetylase HDAC5 0.0659 0.1513 0.4153
Loa Loa (eye worm) hypothetical protein 0.0731 0.1683 0.4639
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0048 0.0075 0.0206
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0029 0.0001
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0048 0.0075 0.0178
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0029 0.0001
Toxoplasma gondii UDP-glucose 4-epimerase 0.0054 0.0089 0.0217
Loa Loa (eye worm) hypothetical protein 0.0909 0.21 0.5789
Schistosoma mansoni carbonic anhydrase-related 0.029 0.0645 0.1755
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0134 0.0122
Entamoeba histolytica hypothetical protein 0.0023 0.0016 0.0045
Schistosoma mansoni jumonji/arid domain-containing protein 0.0116 0.0234 0.0618
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0016 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.004 0.0056 0.0156
Echinococcus multilocularis lysine specific demethylase 6a 0.003 0.0033 0.0063
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0028 0.0016
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0045 0.0002
Echinococcus multilocularis chromobox protein 1 0.0084 0.016 0.0413
Loa Loa (eye worm) RGS-3 protein 0.0023 0.0016 0.0045
Trichomonas vaginalis histone deacetylase, putative 0.1558 0.3628 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.029 0.0645 0.1779
Plasmodium falciparum phd finger protein, putative 0.0035 0.0045 0.0095
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0487 0.1108 0.3035
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0198 0.0519
Brugia malayi histone deacetylase 3 (HD3) 0.1558 0.3628 1
Echinococcus multilocularis histone deacetylase 1 0.1558 0.3628 1
Leishmania major histone deacetylase, putative 0.1558 0.3628 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.1558 0.3628 1
Brugia malayi hypothetical protein 0.0023 0.0016 0.0045
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.0016 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0048 0.0105
Loa Loa (eye worm) hypothetical protein 0.01 0.0198 0.0546
Trypanosoma brucei histone deacetylase 4 0.1307 0.3039 0.8377
Toxoplasma gondii histone lysine demethylase JMJD6a 0.003 0.0033 0.0063
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0016 0.0016
Echinococcus granulosus histone deacetylase 0.1307 0.3039 0.8373
Trypanosoma cruzi histone deacetylase, putative 0.1307 0.3039 0.8377
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0016 0.0016
Brugia malayi chromobox protein homolog 3 0.0047 0.0073 0.02
Onchocerca volvulus 0.0114 0.023 0.1518
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0016 0.0016
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0271 0.0746
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0083 0.0157 0.0404
Echinococcus multilocularis UDP glucose 4 epimerase 0.0054 0.0089 0.0217
Mycobacterium ulcerans hypothetical protein 0.003 0.0031 0.0019
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0425 0.1146
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0016 0.0045
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0083 0.0201
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0064 0.0178
Trichomonas vaginalis UDP-glucose 4-epimerase, putative 0.0054 0.0089 0.0245
Brugia malayi Histone deacetylase family protein 0.1307 0.3039 0.8377
Echinococcus multilocularis histone deacetylase 6 0.1307 0.3039 0.8373
Brugia malayi BRCA1-associated protein 2 containing protein 0.0083 0.0157 0.0432
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0045 0.0095
Echinococcus granulosus dnaJ subfamily B 0.0494 0.1124 0.308
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0088 0.017 0.0441
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0083 0.0157 0.0404
Echinococcus multilocularis dnaJ subfamily C 6 0.0074 0.0136 0.0347
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0083 0.0157 0.0432
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0029 0.008
Echinococcus multilocularis histone deacetylase 8 0.0659 0.1513 0.4153
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0045 0.0095
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0083 0.0157 0.0404
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.003 0.0033 0.0091
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0487 0.1108 0.3055
Schistosoma mansoni phd/f-box containing protein 0.003 0.0033 0.0063
Plasmodium vivax histone deacetylase, putative 0.0659 0.1513 0.4153
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0198 0.0546
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.1558 0.3628 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0003 0.0007
Entamoeba histolytica phosphomannose isomerase, putative 0.0117 0.0238 0.0656
Loa Loa (eye worm) hypothetical protein 0.0037 0.0048 0.0133
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0083 0.0157 0.0432
Toxoplasma gondii hypothetical protein 0.029 0.0645 0.1755
Schistosoma mansoni carbonic anhydrase-related 0.029 0.0645 0.1755
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.0017
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0198 0.0519
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0048 0.0075 0.0206
Brugia malayi PXA domain containing protein 0.0023 0.0016 0.0045
Echinococcus granulosus carbonic anhydrase 0.029 0.0645 0.1755
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0083 0.0157 0.0404
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0012 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0048 0.0105
Toxoplasma gondii histone lysine methyltransferase SET1 0.0071 0.013 0.033
Plasmodium falciparum carbonic anhydrase 0.029 0.0645 0.1755
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0013 0.0035
Schistosoma mansoni carbonic anhydrase 0.029 0.0645 0.1755
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0566 0.1561
Schistosoma mansoni jumonji domain containing protein 0.003 0.0033 0.0063
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0134 0.0343
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0048 0.0075 0.0178
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0793 0.2184
Schistosoma mansoni chromobox protein 0.0084 0.016 0.0413
Echinococcus multilocularis carbonic anhydrase 0.029 0.0645 0.1755
Brugia malayi Bromodomain containing protein 0.0039 0.0055 0.0151
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0083 0.0157 0.0432
Trypanosoma cruzi phosphomannose isomerase, putative 0.0117 0.0238 0.0656
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.0064 0.0112 0.0104
Schistosoma mansoni protein phosphatase 2C 0.003 0.0033 0.0063
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0048 0.0105
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0064 0.0178
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.0017
Loa Loa (eye worm) histone deacetylase 11 0.0659 0.1513 0.4169
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0083 0.0157 0.0432
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0083 0.0157 0.0432
Echinococcus multilocularis histone deacetylase 3 0.1558 0.3628 1
Brugia malayi histone deacetylase 1 (HD1) 0.1558 0.3628 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0016 0.0016
Echinococcus multilocularis lysine specific demethylase 5A 0.0114 0.0229 0.0605
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0064 0.015
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0083 0.0157 0.0404
Echinococcus multilocularis cpg binding protein 0.0072 0.013 0.0332
Onchocerca volvulus Alhambra homolog 0.0035 0.0045 0.0295
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0117 0.0238 0.0656
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0016 0.0045
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0029 0.008
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0017 0.0046
Leishmania major phosphomannose isomerase 0.0117 0.0238 0.0656
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0064 0.0178
Schistosoma mansoni UDP-glucose 4-epimerase 0.0054 0.0089 0.0217
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0031 0.0086
Trichomonas vaginalis set domain proteins, putative 0.0287 0.0637 0.1755
Echinococcus granulosus chromobox protein 1 0.0084 0.016 0.0413
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0045
Plasmodium vivax SET domain protein, putative 0.0037 0.0048 0.0105
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0083 0.0157 0.0432
Echinococcus granulosus phd:f box containing protein 0.003 0.0033 0.0063
Onchocerca volvulus 0.0287 0.0637 0.421
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0073 0.02
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0013 0.0035
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0031 0.0019
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0045 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0073 0.02
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0029 0.008
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0064 0.015
Plasmodium vivax histone deacetylase, putative 0.1307 0.3039 0.8373
Trichomonas vaginalis histone deacetylase, putative 0.1558 0.3628 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0134 0.0343
Mycobacterium ulcerans hypothetical protein 0.003 0.0031 0.0019
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0033 0.0091
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0028 0.0049
Entamoeba histolytica hypothetical protein 0.0023 0.0016 0.0045
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0021 0.001 0.0028
Trichomonas vaginalis histone deacetylase, putative 0.1558 0.3628 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.0793 0.2184
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0374 0.103
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0077 0.0184
Schistosoma mansoni cpg binding protein 0.0072 0.013 0.0332
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0073 0.0173
Trypanosoma cruzi histone deacetylase, putative 0.0659 0.1513 0.4169
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.029 0.0645 0.1779
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0045 0.0125
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0029 0.008
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0045 0.0095
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0048 0.0075 0.0178
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0013 0.0035
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0016 0.0045
Echinococcus multilocularis carbonic anhydrase 0.029 0.0645 0.1755
Loa Loa (eye worm) hypothetical protein 0.0037 0.0049 0.0134
Loa Loa (eye worm) hypothetical protein 0.0659 0.1513 0.4169
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0083 0.0157 0.0404
Trichomonas vaginalis brca1-associated protein, putative 0.0083 0.0157 0.0432
Loa Loa (eye worm) histone deacetylase 3 0.1558 0.3628 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.007 0.0126 0.0347
Loa Loa (eye worm) carbonic anhydrase 3 0.0487 0.1108 0.3055
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0048 0.0075 0.0206
Trypanosoma cruzi histone deacetylase, putative 0.1307 0.3039 0.8377
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.029 0.0645 0.1779
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0031 0.0086
Echinococcus granulosus carbonic anhydrase 0.029 0.0645 0.1755
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0029 0.008
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0045 0.0096
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0028 0.0078
Echinococcus granulosus jumonji domain containing 1A 0.003 0.0033 0.0063
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0045
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0048 0.0075 0.0206
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0083 0.0157 0.0432
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0029 0.008
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.003 0.0033 0.0063
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0271 0.0746
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.003 0.0033 0.0091
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0029 0.008
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0004 0.0011
Leishmania major histone deacetylase, putative 0.1307 0.3039 0.8377
Trypanosoma cruzi histone deacetylase 1, putative 0.1558 0.3628 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0487 0.1108 0.3035
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0271 0.0746
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0064 0.0178
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0083 0.0201
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.4265 1 1
Echinococcus multilocularis phd:f box containing protein 0.003 0.0033 0.0063
Plasmodium falciparum histone deacetylase 1 0.1558 0.3628 1
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.0271 0.072
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0083 0.0157 0.0432
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0033
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0077 0.0184
Echinococcus granulosus BRCA1 associated protein 0.0083 0.0157 0.0404
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0032 0.0038 0.0076
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0054 0.0089 0.0245
Leishmania major carbonic anhydrase-like protein 0.0487 0.1108 0.3055
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.004 0.0111
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0033 0.0091
Schistosoma mansoni jumonji domain containing protein 0.0163 0.0345 0.0924
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0016 0.0045
Loa Loa (eye worm) UDP galactose 4'-epimerase 0.0054 0.0089 0.0245
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.0083 0.0157 0.0404
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0081 0.0224
Brugia malayi Heterochromatin protein 1 0.0084 0.016 0.044
Echinococcus granulosus carbonic anhydrase II 0.0487 0.1108 0.3035
Echinococcus multilocularis citrate lyase subunit beta protein 0.003 0.0031 0.0058
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0133 0.0366
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0271 0.0746
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0016 0.0016
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0016 0.0016
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.003 0.0031 0.0019
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0064 0.0178
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0362 0.0973
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0045
Echinococcus multilocularis BRCA1 associated protein 0.0083 0.0157 0.0404
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0083 0.0157 0.0404
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0016 0.0016
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0134 0.0343
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.0045 0.0125
Trypanosoma brucei histone deacetylase, putative 0.1307 0.3039 0.8377
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0073 0.0481
Echinococcus multilocularis JmjC domain containing protein 4 0.003 0.0033 0.0063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0793 0.2184
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.0271 0.0259
Mycobacterium ulcerans hypothetical protein 0.0029 0.0029 0.0017
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0271 0.072
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0186 0.04 0.1078
Giardia lamblia UDP-glucose 4-epimerase 0.0052 0.0084 0.0111
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0054 0.0089 0.0245
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0012 0.0005
Echinococcus multilocularis histone deacetylase 7 0.1307 0.3039 0.8373
Echinococcus granulosus cpg binding protein 0.0072 0.013 0.0332
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.0016 0.0016
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.0016 0.0016
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0021 0.001 0.0028
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0131 0.0271 0.0243
Echinococcus granulosus histone deacetylase 6 0.1307 0.3039 0.8373
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0045 0.0125
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.0016 0.0016
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0045 0.0095
Trypanosoma brucei phosphomannose isomerase 0.0117 0.0238 0.0656
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0117 0.0238 0.063
Echinococcus granulosus expressed protein 0.0451 0.1023 0.2799
Brugia malayi jmjC domain containing protein 0.003 0.0033 0.0091
Trypanosoma brucei carbonic anhydrase-like protein 0.0487 0.1108 0.3055
Loa Loa (eye worm) hypothetical protein 0.029 0.0645 0.1779
Brugia malayi Pre-SET motif family protein 0.0252 0.0555 0.153
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0064 0.0178
Echinococcus granulosus histone deacetylase 7 0.1307 0.3039 0.8373
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0029 0.008
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.016 0.044
Giardia lamblia Histone deacetylase 0.1558 0.3628 1
Schistosoma mansoni alpha-glucosidase 0.0169 0.036 0.0968
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0083 0.0157 0.0432
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0045
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.0555 0.153
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.0793 0.2184
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0368 0.0363
Schistosoma mansoni phosphatidylserine receptor 0.003 0.0033 0.0063
Brugia malayi phosphofructokinase 0.0131 0.0271 0.0746
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0013 0.0035
Brugia malayi Pre-SET motif family protein 0.0037 0.0048 0.0133
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0016 0.0016
Trypanosoma brucei histone deacetylase 2 0.0659 0.1513 0.4169
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0029 0.0017
Brugia malayi DnaJ domain containing protein 0.0074 0.0136 0.0374
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0117 0.0238 0.063
Loa Loa (eye worm) hypothetical protein 0.003 0.0033 0.0091
Echinococcus granulosus carbonic anhydrase 0.029 0.0645 0.1755
Schistosoma mansoni hypothetical protein 0.0035 0.0045 0.0095
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0064 0.0178
Trichomonas vaginalis histone deacetylase, putative 0.1558 0.3628 1
Loa Loa (eye worm) histone deacetylase 1 0.1558 0.3628 1
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0271 0.0746
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0487 0.1108 0.3055
Onchocerca volvulus Histone deacetylase 10 homolog 0.0659 0.1513 1
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) 0.4217 0.9887 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0035 0.0045 0.0222
Echinococcus granulosus UDP glucose 4 epimerase 0.0054 0.0089 0.0217
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0064 0.0178
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0793 0.2184
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0073 0.0201
Toxoplasma gondii histone deacetylase HDAC3 0.1558 0.3628 1
Brugia malayi jmjC domain containing protein 0.0116 0.0234 0.0645
Schistosoma mansoni alpha-glucosidase 0.0169 0.036 0.0968
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0081 0.0224
Trichomonas vaginalis protein kinase inhibitor, putative 0.0074 0.0136 0.0374
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0083 0.0157 0.0432
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0271 0.0746
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0045 0.0125
Toxoplasma gondii histone deacetylase HDAC2 0.1558 0.3628 1
Leishmania major histone deacetylase, putative 0.1307 0.3039 0.8377
Echinococcus granulosus histone deacetylase 8 0.0659 0.1513 0.4153
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0271 0.072
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.0271 0.3173
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.0016 0.0045
Echinococcus granulosus histone deacetylase 1 0.1558 0.3628 1
Brugia malayi UDP galactose 4'-epimerase 0.0054 0.0089 0.0245
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0016 0.0016
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0368 0.0356
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0054 0.0088 0.0243
Leishmania major histone deacetylase, putative 0.1558 0.3628 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.0016 0.0045
Echinococcus granulosus mannose 6 phosphate isomerase 0.0117 0.0238 0.063
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0043 0.0092
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.0016 0.0045
Brugia malayi CXXC zinc finger family protein 0.007 0.0126 0.0347
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0012 0.0005
Schistosoma mansoni hypothetical protein 0.029 0.0645 0.1755
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0064 0.0112 0.0084
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0064 0.0178
Trichomonas vaginalis chromobox protein, putative 0.0084 0.016 0.044
Echinococcus multilocularis histone deacetylase 0.1307 0.3039 0.8373
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0793 0.2184
Trichomonas vaginalis BRCA1-associated protein, putative 0.0083 0.0157 0.0432
Echinococcus granulosus dnaJ subfamily C 6 0.0074 0.0136 0.0347
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.0271 0.072
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0083 0.0228
Schistosoma mansoni carbonic anhydrase-related 0.029 0.0645 0.1755
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0123
Plasmodium falciparum JmjC domain-containing protein, putative 0.003 0.0033 0.0063
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0029 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0033
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0041 0.0059 0.0135
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0016 0.0016
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0064 0.0178
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.1923 0.5288
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0031 0.0019
Trypanosoma cruzi phosphomannose isomerase, putative 0.0117 0.0238 0.0656
Giardia lamblia Hypothetical protein 0.0083 0.0157 0.0312
Echinococcus multilocularis jumonji domain containing 1A 0.003 0.0033 0.0063
Leishmania major hypothetical protein, conserved 0.0257 0.0566 0.1561
Echinococcus granulosus JmjC domain containing protein 4 0.003 0.0033 0.0063
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.0045 0.0125
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0045 0.0096
Leishmania major udp-glc 4-epimerase, putative 0.0052 0.0084 0.0233
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0073 0.0079
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0083 0.0157 0.0432
Mycobacterium leprae N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) 0.0048 0.0075 0.0047
Schistosoma mansoni histone deacetylase 4 5 0.1307 0.3039 0.8373
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.0083 0.0157 0.1035
Schistosoma mansoni histone deacetylase 1 2 3 0.0659 0.1513 0.4153
Echinococcus multilocularis histone deacetylase 6 0.1307 0.3039 0.8373
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0016 0.0016
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0045 0.0096
Brugia malayi jmjC domain containing protein 0.003 0.0033 0.0091
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0374 0.1005
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0186 0.04 0.1078
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.003 0.0031 0.0022
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0028 0.4866
Brugia malayi PXA domain containing protein 0.0023 0.0016 0.0045
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0013 0.0035
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0048 0.0075 0.0206
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0045
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.004 0.0111
Leishmania major modification methylase-like protein 0.0021 0.001 0.0028
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0029 0.002
Onchocerca volvulus 0.004 0.0056 0.0373
Echinococcus granulosus microtubule associated protein 2 0.0833 0.1923 0.5288
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0032 0.0038 0.0076
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0028 0.5
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0083 0.0157 0.0432
Schistosoma mansoni chromobox protein 0.0084 0.016 0.0413
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0064 0.0178
Brugia malayi PHD-finger family protein 0.0035 0.0045 0.0123
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0048 0.0075 0.0206
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0045 0.0123
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0033 0.0091
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0793 0.2184
Trypanosoma brucei histone deacetylase 1 0.1558 0.3628 1
Leishmania major hypothetical protein, conserved 0.0083 0.0157 0.0432
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0016 0.0045
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0016 0.0016
Trypanosoma brucei glucosidase, putative 0.0044 0.0064 0.0178
Schistosoma mansoni mannose-6-phosphate isomerase 0.0117 0.0238 0.063
Loa Loa (eye worm) histone deacetylase 0.1307 0.3039 0.8377
Echinococcus multilocularis histone deacetylase 6 0.139 0.3234 0.8911
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0016 0.0016
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.0793 0.2087
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.008
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0051 0.0081 0.0195
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0048 0.0075 0.0206
Brugia malayi Histone deacetylase 1 0.1558 0.3628 1
Trypanosoma cruzi histone deacetylase, putative 0.0659 0.1513 0.4169
Trypanosoma cruzi UDP-galactose 4-epimerase 0.0054 0.0089 0.0245
Plasmodium vivax hypothetical protein, conserved 0.0083 0.0157 0.0404
Entamoeba histolytica hypothetical protein 0.0028 0.0028 0.0078
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.029 0.0645 0.1779
Schistosoma mansoni histone deacetylase 4 5 0.1307 0.3039 0.8373
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0134 0.037
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0064 0.0178
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0083 0.0157 0.0432
Echinococcus granulosus histone deacetylase 6 0.139 0.3234 0.8911
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0045 0.0095
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0016 0.0045
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0033 0.0091
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0064 0.0178
Brugia malayi histone deacetylase 11 0.0659 0.1513 0.4169
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0271 0.0746
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0031 0.0086
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0081 0.0537
Echinococcus multilocularis disco interacting protein 2 0.0041 0.0059 0.0135
Loa Loa (eye worm) acetyltransferase 0.0175 0.0374 0.103
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0016 0.0016
Plasmodium vivax histone deacetylase 1, putative 0.1558 0.3628 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0033
Toxoplasma gondii hypothetical protein 0.0088 0.017 0.0441
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0016 0.0016
Echinococcus granulosus lysine specific demethylase 6a 0.003 0.0033 0.0063
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0117 0.0238 0.063
Loa Loa (eye worm) phosphofructokinase 0.0131 0.0271 0.0746
Brugia malayi 6-phosphofructokinase 0.0131 0.0271 0.0746
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0045 1
Toxoplasma gondii histone deacetylase HDAC4 0.0659 0.1513 0.4153
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0045 0.0125
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0117 0.0238 0.0656
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0016 0.0045
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0083 0.0157 0.0404
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0083 0.0157 0.0432
Mycobacterium tuberculosis N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) 0.0048 0.0075 0.0066
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0029 0.0017
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0083 0.0157 0.0404
Plasmodium falciparum histone deacetylase, putative 0.1307 0.3039 0.8373
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0048 0.0075 0.0178
Leishmania major hypothetical protein, conserved 0.0083 0.0157 0.0432
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0045 0.0096
Echinococcus multilocularis chromobox protein 1 0.0084 0.016 0.0413
Trypanosoma brucei UDP-galactose 4-epimerase 0.0052 0.0084 0.0233
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.003 0.0033 0.0063
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0029 0.008
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0083 0.0201
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.0566 0.1561
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0045 0.0096
Schistosoma mansoni jumonji/arid domain-containing protein 0.0116 0.0234 0.0618
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0425 0.1146
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.0271 0.0265
Trypanosoma cruzi histone deacetylase, putative 0.1307 0.3039 0.8377
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0271 0.0746
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0016 0.0016
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0083 0.0228
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.0425 0.1171
Trichomonas vaginalis Citrate lyase beta chain, putative 0.003 0.0031 0.0086
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.1558 0.3628 1
Brugia malayi jmjC domain containing protein 0.003 0.0033 0.0091
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0198 0.0519
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.008
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0029 0.0017
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0028 0.0049
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0012 0.0003
Echinococcus granulosus peregrin 0.0039 0.0055 0.0123
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0064 0.0178
Entamoeba histolytica UDP-glucose 4-epimerase, putative 0.0054 0.0089 0.0245
Schistosoma mansoni hypothetical protein 0.0494 0.1124 0.308
Loa Loa (eye worm) jmjC domain-containing protein 0.0116 0.0234 0.0645
Brugia malayi Histone deacetylase family protein 0.1307 0.3039 0.8377
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0045 0.0096
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0048 0.0105
Loa Loa (eye worm) hypothetical protein 0.029 0.0645 0.1779
Onchocerca volvulus 0.007 0.0126 0.0832
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0374 0.1005
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.0016 0.0045
Echinococcus multilocularis carbonic anhydrase II 0.0487 0.1108 0.3035
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.0793 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0148 0.0409
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0083 0.0157 0.0432
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0117 0.0238 0.0656
Echinococcus granulosus lysine specific demethylase 5A 0.0116 0.0234 0.0618
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0029 0.0017
Brugia malayi jmjC domain containing protein 0.003 0.0033 0.0091
Schistosoma mansoni histone deacetylase hda2 0.139 0.3234 0.8911
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0083 0.0157 0.0312

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.8435 um PUBCHEM_BIOASSAY: HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay using a high concentration of mannose 6-phosphate. (Class of assay: confirmatory) [Related pubchem assays: 1209 ] ChEMBL. No reference
IC50 (functional) 7.65 uM PUBCHEM_BIOASSAY: Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1909, AID2102, AID2501, AID2615, AID2775, AID449729, AID485276, AID485288] ChEMBL. No reference
IC50 (binding) = 30.028 um PUBCHEM_BIOASSAY: HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. (Class of assay: confirmatory) [Related pubchem assays: 1220 ] ChEMBL. No reference
IC50 (functional) 57.4 uM PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay using Cy5 labeled peptide. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 3.0131 uM PUBCHEM_BIOASSAY: Tb PFK orthogonal confirmatory assay using ATP depletion (Kinase-Glo Plus) as an alternative measure of Tb PFK activity: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 7.5686 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 8.8914 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 9.5283 uM PUBCHEM_BIOASSAY: Inhibitors of T. brucei phosphofructokinase: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.1014 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 19.8003 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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