Detailed information for compound 1413945

Basic information

Technical information
  • TDR Targets ID: 1413945
  • Name: N-(2-chlorophenyl)-2-[4-thiophen-2-yl-6-(trif luoromethyl)pyrimidin-2-yl]sulfanylacetamide
  • MW: 429.867 | Formula: C17H11ClF3N3OS2
  • H donors: 1 H acceptors: 3 LogP: 4.88 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1Cl)CSc1nc(cc(n1)C(F)(F)F)c1cccs1
  • InChi: 1S/C17H11ClF3N3OS2/c18-10-4-1-2-5-11(10)22-15(25)9-27-16-23-12(13-6-3-7-26-13)8-14(24-16)17(19,20)21/h1-8H,9H2,(H,22,25)
  • InChiKey: PBAWHWMFEKTSEG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-chlorophenyl)-2-[4-(2-thienyl)-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl-acetamide
  • N-(2-chlorophenyl)-2-[[4-(2-thienyl)-6-(trifluoromethyl)-2-pyrimidinyl]thio]acetamide
  • N-(2-chlorophenyl)-2-[[4-(2-thienyl)-6-(trifluoromethyl)pyrimidin-2-yl]thio]acetamide
  • N-(2-chlorophenyl)-2-[4-thiophen-2-yl-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl-ethanamide
  • BAS 03153557
  • AN-329/42285876
  • NCGC00101278-01
  • ST5270154

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus insulin receptor 0.1296 0.346 0.3458
Echinococcus granulosus tyrosine protein kinase Src64B 0.0434 0.0938 0.0935
Trichomonas vaginalis CK1 family protein kinase 0.0217 0.0302 0.1419
Brugia malayi Stress-activated protein kinase jnk-1 0.0753 0.1872 0.2409
Brugia malayi probable protein kinase 0.032 0.0605 0.0776
Brugia malayi protein-tyrosine kinase 0.0363 0.0731 0.0938
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0224 0.0323 0.032
Giardia lamblia Kinase, CMGC CDK 0.0321 0.0608 0.3127
Plasmodium falciparum serine/threonine protein kinase KIN 0.0167 0.0158 0.1655
Trypanosoma brucei cdc2-related kinase 3 0.0321 0.0608 0.2975
Echinococcus multilocularis 0.0121 0.0023 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0157 0.0129 0.0555
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.035 0.0694 0.1424
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0441 0.0958 0.4956
Echinococcus multilocularis casein kinase I gamma 0.0187 0.0215 0.0305
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0154 0.0119 0.0543
Echinococcus multilocularis tyrosine protein kinase Abl 0.0495 0.1117 0.1605
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0167 0.0158 0.0222
Loa Loa (eye worm) hypothetical protein 0.0353 0.0702 0.09
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0635 0.1526 0.1964
Brugia malayi Protein kinase domain containing protein 0.0615 0.1467 0.1888
Schistosoma mansoni serine/threonine protein kinase 0.053 0.1218 0.25
Loa Loa (eye worm) TK/FER protein kinase 0.0189 0.0221 0.0281
Echinococcus multilocularis PAK box P21 Rho binding 0.0159 0.0135 0.0189
Echinococcus granulosus serine:threonine protein kinase 12 B 0.04 0.084 0.0837
Echinococcus granulosus epidermal growth factor receptor 0.1779 0.4872 0.487
Echinococcus granulosus cGMP dependent protein kinase 0.0168 0.0161 0.0157
Brugia malayi casein kinase 1, delta 0.0217 0.0302 0.0385
Schistosoma mansoni protein kinase 0.0224 0.0323 0.0664
Giardia lamblia Kinase, NEK 0.0373 0.0759 0.3914
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0022 0.0044
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0179 0.0192 0.0188
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0266 0.0446 0.057
Loa Loa (eye worm) hypothetical protein 0.0189 0.0221 0.0281
Echinococcus multilocularis myosin iiia 0.022 0.0312 0.0444
Trichomonas vaginalis AGC family protein kinase 0.0225 0.0328 0.1545
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0434 0.0938 0.0935
Echinococcus granulosus serine:threonine kinase SAD 1 0.0167 0.0158 0.0154
Loa Loa (eye worm) TK/INSR protein kinase 0.1296 0.346 0.4458
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0118 0.0013 0.0013
Brugia malayi Protein kinase domain containing protein 0.0483 0.1082 0.139
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0273 0.0468 0.0961
Schistosoma mansoni titin 0.0133 0.0057 0.0116
Brugia malayi intracellular kinase 0.035 0.0694 0.089
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0133 0.0059 0.012
Schistosoma mansoni septate junction protein 0.0115 0.0004 0.0008
Echinococcus multilocularis cyclin dependent kinase 1 0.0321 0.0608 0.0871
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.02 0.0253 0.0359
Loa Loa (eye worm) TK/FER protein kinase 0.0189 0.0221 0.0281
Brugia malayi Tyrosine-protein kinase abl-1 0.038 0.0781 0.1003
Brugia malayi Temporarily assigned gene name protein 59 0.0383 0.0789 0.1013
Brugia malayi Hr1 repeat family protein 0.0549 0.1274 0.1639
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1308 0.3495 0.5031
Schistosoma mansoni protein kinase 0.0513 0.1169 0.2399
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0256 0.0418 0.0414
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0225 0.0328 0.0467
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0753 0.1872 0.2409
Brugia malayi Immunoglobulin I-set domain containing protein 0.0127 0.0039 0.0045
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0529 0.1216 0.1213
Trichomonas vaginalis CMGC family protein kinase 0.0266 0.0446 0.2135
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.0217 0.0445
Trichomonas vaginalis CAMK family protein kinase 0.0344 0.0674 0.3273
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0179 0.0192 0.0243
Loa Loa (eye worm) AUR protein kinase 0.04 0.084 0.1079
Loa Loa (eye worm) TK protein kinase 0.0275 0.0474 0.0607
Trichomonas vaginalis AGC family protein kinase 0.04 0.084 0.4102
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0434 0.0938 0.1346
Echinococcus multilocularis cyclin dependent kinase 5 0.0321 0.0608 0.0871
Schistosoma mansoni protein kinase 0.0513 0.1169 0.2399
Trichomonas vaginalis STE family protein kinase 0.0373 0.0759 0.3697
Brugia malayi SH2 domain containing protein 0.0189 0.0221 0.0281
Echinococcus granulosus nervana 2 0.0367 0.0743 0.0739
Echinococcus granulosus cyclin dependent kinase 1 0.0321 0.0608 0.0605
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0127 0.0039 0.0051
Entamoeba histolytica protein kinase, putative 0.04 0.084 0.4126
Entamoeba histolytica protein kinase 2, putative 0.0433 0.0937 0.4607
Giardia lamblia Kinase, CDC7 0.0123 0.0029 0.0102
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0331 0.0638 0.0818
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0224 0.0323 0.032
Plasmodium vivax serine/threonine protein kinase 6, putative 0.04 0.084 0.8963
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.2765 0.7757 1
Loa Loa (eye worm) hypothetical protein 0.0412 0.0874 0.1122
Schistosoma mansoni protein kinase 0.0217 0.0302 0.0621
Brugia malayi protein kinase C II. 0.0532 0.1224 0.1574
Brugia malayi casein kinase I 0.0217 0.0302 0.0385
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0513 0.1169 0.1679
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0541 0.1251 0.1796
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0262 0.0434 0.062
Toxoplasma gondii AGC kinase 0.0786 0.1968 1
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0168 0.0159 0.0742
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0167 0.0158 0.0199
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0224 0.0323 0.032
Brugia malayi serine/threonine kinase 12 0.04 0.084 0.1079
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.069 0.1687 0.1684
Schistosoma mansoni adapter molecule crk 0.0159 0.0132 0.0271
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0187 0.0217 0.1085
Echinococcus granulosus protein kinase c iota type 0.0774 0.1933 0.1931
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0453 0.0995 0.1279
Echinococcus multilocularis RNA directed DNA polymerase 0.0118 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0304 0.0557 0.0714
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0453 0.0995 0.1429
Echinococcus multilocularis tyrosine protein kinase shark 0.0189 0.0221 0.0314
Trichomonas vaginalis CAMK family protein kinase 0.0771 0.1924 0.9511
Schistosoma mansoni serine/threonine-protein kinase 0.0452 0.0991 0.2033
Echinococcus multilocularis hypothetical protein 0.0222 0.0319 0.0454
Schistosoma mansoni rap gtpase-activating protein 0.0133 0.0059 0.012
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0217 0.0302 0.0385
Echinococcus granulosus protein kinase C gamma type 0.054 0.1249 0.1246
Toxoplasma gondii aurora kinase 0.04 0.084 0.4258
Schistosoma mansoni serine/threonine protein kinase 0.0167 0.0158 0.0324
Entamoeba histolytica protein kinase, putative 0.0275 0.0474 0.2308
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0371 0.0754 0.0968
Schistosoma mansoni serine/threonine protein kinase 0.0167 0.0158 0.0324
Toxoplasma gondii AGC kinase 0.0225 0.0328 0.165
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0217 0.0304 0.1535
Entamoeba histolytica protein kinase domain containing protein 0.0331 0.0638 0.3123
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0168 0.0159 0.078
Schistosoma mansoni protein kinase 0.0187 0.0215 0.0442
Plasmodium falciparum calcium-dependent protein kinase 2 0.0179 0.0192 0.2018
Loa Loa (eye worm) hypothetical protein 0.0118 0.0013 0.0012
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0321 0.0608 0.078
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0193 0.0233 0.0296
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.012 0.0018 0.0019
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0669 0.1624 0.2335
Echinococcus multilocularis mitogen activated protein kinase 11 0.0441 0.0958 0.1376
Echinococcus granulosus tyrosine protein kinase HCK 0.0275 0.0474 0.0471
Trichomonas vaginalis CAMK family protein kinase 0.0167 0.0158 0.0698
Echinococcus multilocularis casein kinase I delta 0.0217 0.0302 0.043
Echinococcus multilocularis tyrosine protein kinase Srms 0.0363 0.0731 0.1047
Onchocerca volvulus 0.019 0.0225 0.0431
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0225 0.0328 0.3474
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0133 0.0059 0.0055
Trypanosoma brucei protein kinase, putative 0.035 0.0694 0.34
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0753 0.1872 0.2691
Echinococcus multilocularis dual specificity 0.012 0.0018 0.0021
Trypanosoma cruzi cdc2-related kinase 3 0.0321 0.0608 0.3127
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0187 0.0217 0.1081
Brugia malayi MAP kinase sur-1 0.0217 0.0304 0.0387
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.0161 0.033
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0398 0.0834 0.1197
Schistosoma mansoni growth factor receptor-bound protein 0.0159 0.0132 0.0271
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0117 0.001 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.021 0.0284 0.0583
Echinococcus granulosus serine:threonine protein kinase 0.0307 0.0568 0.0564
Trichomonas vaginalis CAMK family protein kinase 0.0167 0.0158 0.0698
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0217 0.0304 0.1535
Brugia malayi hypothetical protein 0.0189 0.0221 0.0281
Entamoeba histolytica cell division protein kinase 2, putative 0.0321 0.0608 0.2975
Loa Loa (eye worm) protein kinase domain-containing protein 0.0187 0.0215 0.0273
Schistosoma mansoni serine/threonine protein kinase 0.0225 0.0328 0.0673
Onchocerca volvulus Tyrosine kinase homolog 0.1867 0.5132 1
Echinococcus multilocularis casein kinase i 0.0217 0.0302 0.043
Schistosoma mansoni serine/threonine protein kinase 0.0549 0.1274 0.2615
Trichomonas vaginalis AGC family protein kinase 0.0804 0.2022 1
Plasmodium vivax protein kinase, putative 0.0126 0.0038 0.0369
Trichomonas vaginalis CMGC family protein kinase 0.0217 0.0304 0.1425
Trichomonas vaginalis CMGC family protein kinase 0.0217 0.0304 0.1425
Brugia malayi cell division control protein 2 homolog 0.0321 0.0608 0.078
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0532 0.1224 0.1574
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0453 0.0995 0.0992
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0115 0.0004 0.0008
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0187 0.0217 0.1028
Entamoeba histolytica protein kinase domain containing protein 0.035 0.0694 0.34
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0179 0.0192 0.0271
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0187 0.0217 0.1081
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0565 0.132 0.1698
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.0304 0.0623
Trichomonas vaginalis CMGC family protein kinase 0.0321 0.0608 0.2945
Loa Loa (eye worm) casein kinase 0.0121 0.0021 0.0022
Echinococcus granulosus neuroglian 0.0328 0.0627 0.0624
Trichomonas vaginalis CAMK family protein kinase 0.0167 0.0158 0.0698
Trichomonas vaginalis CMGC family protein kinase 0.0321 0.0608 0.2945
Echinococcus multilocularis casein kinase I alpha 0.0217 0.0302 0.043
Echinococcus multilocularis activin receptor type 0.0168 0.0159 0.0224
Echinococcus multilocularis ephrin type A receptor 4 A 0.0291 0.0521 0.0745
Trichomonas vaginalis CMGC family protein kinase 0.0266 0.0446 0.2135
Schistosoma mansoni tyrosine kinase 0.0717 0.1766 0.3625
Plasmodium falciparum casein kinase 1 0.0217 0.0302 0.3202
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.04 0.084 0.4126
Echinococcus multilocularis mitogen activated protein kinase 14 0.0441 0.0958 0.1376
Schistosoma mansoni serine/threonine protein kinase 0.0117 0.001 0.002
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0227 0.0332 0.0423
Loa Loa (eye worm) hypothetical protein 0.0337 0.0654 0.0838
Echinococcus multilocularis protein kinase c iota type 0.0774 0.1933 0.278
Entamoeba histolytica protein kinase, putative 0.04 0.084 0.4126
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.02 0.0253 0.0249
Schistosoma mansoni serine/threonine protein kinase 0.0321 0.0608 0.1248
Trichomonas vaginalis STE family protein kinase 0.0224 0.0323 0.1524
Onchocerca volvulus 0.0867 0.2206 0.4295
Loa Loa (eye worm) CAMK/PKD protein kinase 0.037 0.0751 0.0964
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0179 0.0192 0.0271
Loa Loa (eye worm) hypothetical protein 0.0128 0.0042 0.0049
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0168 0.0161 0.0226
Trichomonas vaginalis CAMK family protein kinase 0.0167 0.0158 0.0698
Trichomonas vaginalis CAMK family protein kinase 0.0167 0.0158 0.0698
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.0247 0.0508
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0236 0.036 0.0514
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0168 0.0161 0.08
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0731 0.1807 0.2326
Entamoeba histolytica casein kinase 1, putative 0.0217 0.0302 0.1455
Giardia lamblia Kinase, CMGC MAPK 0.0217 0.0304 0.1535
Entamoeba histolytica protein kinase, putative 0.0331 0.0638 0.3123
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0133 0.0057 0.0068
Echinococcus multilocularis Immunoglobulin 0.0273 0.0468 0.0669
Echinococcus multilocularis casein kinase I alpha 0.0217 0.0302 0.043
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.0192 0.0394
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0434 0.0938 0.1346
Trichomonas vaginalis AGC family protein kinase 0.021 0.0284 0.1327
Schistosoma mansoni serine/threonine protein kinase 0.0453 0.0995 0.2043
Trichomonas vaginalis CMGC family protein kinase 0.0266 0.0446 0.2135
Schistosoma mansoni cell adhesion molecule 0.0115 0.0004 0.0008
Echinococcus granulosus tyrosine kinase 0.0189 0.0221 0.0218
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0117 0.001 0.0008
Brugia malayi Kinase associated domain 1 family protein 0.0222 0.0319 0.0407
Trichomonas vaginalis AGC family protein kinase 0.0373 0.0759 0.3697
Entamoeba histolytica protein kinase, putative 0.0804 0.2022 1
Echinococcus granulosus tyrosine protein kinase shark 0.0189 0.0221 0.0218
Echinococcus granulosus protein kinase 0.0187 0.0215 0.0212
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0225 0.0328 0.0467
Trichomonas vaginalis CAMK family protein kinase 0.0771 0.1924 0.9511
Schistosoma mansoni cell adhesion molecule 0.0127 0.0039 0.008
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0422 0.0904 0.0901
Echinococcus granulosus growth factor receptor bound protein 2 0.0159 0.0132 0.0129
Trichomonas vaginalis STE family protein kinase 0.0224 0.0323 0.1524
Onchocerca volvulus 0.0143 0.0088 0.0164
Giardia lamblia Kinase, CMGC GSK 0.035 0.0694 0.3575
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0217 0.0304 0.1535
Echinococcus multilocularis serine:threonine protein kinase 38 0.0419 0.0894 0.1283
Plasmodium vivax calcium-dependent protein kinase, putative 0.0179 0.0192 0.2018
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0179 0.0192 0.0959
Brugia malayi STE20-like kinase MST 0.0731 0.1807 0.2326
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0189 0.0221 0.0314
Echinococcus granulosus dual specificity 0.0331 0.0638 0.0635
Echinococcus multilocularis protein kinase c epsilon type 0.0532 0.1224 0.1759
Trichomonas vaginalis CAMK family protein kinase 0.0167 0.0158 0.0698
Giardia lamblia Aurora kinase 0.04 0.084 0.4338
Brugia malayi Temporarily assigned gene name protein 59 0.0133 0.0059 0.0071
Schistosoma mansoni vav2 0.0215 0.0298 0.0612
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0187 0.0217 0.0275
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0133 0.0059 0.0079
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0656 0.1587 0.2281
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0256 0.0418 0.0597
Echinococcus multilocularis mitogen activated protein kinase 14 0.0441 0.0958 0.1376
Echinococcus granulosus tyrosine protein kinase ABL1 0.0805 0.2023 0.202
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0127 0.0039 0.0051
Trichomonas vaginalis CAMK family protein kinase 0.0167 0.0158 0.0698
Echinococcus multilocularis fibroblast growth factor receptor 4 0.069 0.1687 0.2425
Entamoeba histolytica protein kinase, putative 0.0179 0.0192 0.0904
Brugia malayi Immunoglobulin I-set domain containing protein 0.0127 0.0039 0.0045
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0189 0.0221 0.1052
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.2107 0.303
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.1139 0.3 0.3865
Echinococcus multilocularis neuroglian 0.0127 0.0039 0.0051
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.021 0.0284 0.028
Echinococcus granulosus casein kinase ii subunit alpha 0.0266 0.0446 0.0442
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0658 0.1592 0.2049
Schistosoma mansoni tyrosine kinase 0.0609 0.145 0.2975
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0434 0.0938 0.1346
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0127 0.0039 0.0051
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0441 0.0958 0.4715
Echinococcus granulosus serine:threonine protein kinase 0.0307 0.0568 0.0564
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0419 0.0894 0.1283
Entamoeba histolytica protein kinase domain containing protein 0.0168 0.0159 0.0742
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0441 0.0958 0.4956
Schistosoma mansoni tyrosine kinase 0.1059 0.2768 0.5681
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0946 0.2435 0.3136
Trichomonas vaginalis AGC family protein kinase 0.0439 0.0954 0.467
Schistosoma mansoni nephrin 0.0127 0.0039 0.008
Echinococcus multilocularis serine:threonine protein kinase 0.0307 0.0568 0.0812
Brugia malayi Protein kinase domain containing protein 0.0123 0.0029 0.0033
Trichomonas vaginalis CAMK family protein kinase 0.0167 0.0158 0.0698
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0224 0.0323 0.0461
Schistosoma mansoni ephrin receptor 0.0291 0.0521 0.1069
Plasmodium falciparum serine/threonine protein kinase 0.0117 0.001 0.0066
Trichomonas vaginalis CMGC family protein kinase 0.0217 0.0304 0.1425
Onchocerca volvulus 0.0189 0.0221 0.0424
Loa Loa (eye worm) TK/EGFR protein kinase 0.1779 0.4872 0.6279
Loa Loa (eye worm) hypothetical protein 0.0127 0.0039 0.0045
Entamoeba histolytica protein kinase domain containing protein 0.012 0.0018 0.0042
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0179 0.0192 0.0959
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0225 0.0328 0.165
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0179 0.0192 0.0243
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0771 0.1924 1
Loa Loa (eye worm) hypothetical protein 0.0388 0.0803 0.1032
Brugia malayi serine/threonine-protein kinase 6 0.04 0.084 0.1079
Brugia malayi Immunoglobulin I-set domain containing protein 0.0744 0.1846 0.2376
Echinococcus granulosus hypothetical protein 0.0121 0.0023 0.0019
Brugia malayi Protein kinase domain containing protein 0.0227 0.0332 0.0423
Trichomonas vaginalis AGC family protein kinase 0.0458 0.1008 0.4939
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0656 0.1587 0.1584
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0256 0.0418 0.0534
Brugia malayi Protein kinase domain containing protein 0.0189 0.0221 0.0281
Trichomonas vaginalis CMGC family protein kinase 0.0123 0.0029 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.0771 0.1924 0.3948
Echinococcus multilocularis dual specificity 0.0331 0.0638 0.0914
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0187 0.0215 0.0273
Brugia malayi RhoGAP domain containing protein 0.0197 0.0244 0.0311
Brugia malayi Protein kinase domain containing protein 0.0189 0.0221 0.0281
Brugia malayi Protein kinase domain containing protein 0.0189 0.0221 0.0281
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0434 0.0938 0.1346
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.0161 0.033
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0321 0.0608 0.3127
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.022 0.0312 0.1577
Trypanosoma brucei polo-like protein kinase 0.0771 0.1924 0.9513
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0179 0.0192 0.0959
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.026 0.0429 0.088
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0419 0.0894 0.0891
Entamoeba histolytica PH domain containing protein kinase, putative 0.0452 0.0991 0.4875
Leishmania major casein kinase II, putative 0.0266 0.0446 0.2279
Plasmodium falciparum NIMA related kinase 1 0.0373 0.0759 0.8093
Trichomonas vaginalis CAMK family protein kinase 0.0167 0.0158 0.0698
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0422 0.0904 0.1161
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0441 0.0958 0.1231
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0127 0.0039 0.0045
Loa Loa (eye worm) hypothetical protein 0.0273 0.0468 0.0599
Schistosoma mansoni serine/threonine protein kinase 0.0541 0.1251 0.2567
Trichomonas vaginalis CMGC family protein kinase 0.0266 0.0446 0.2135
Schistosoma mansoni serine/threonine protein kinase 0.0532 0.1224 0.2513
Loa Loa (eye worm) hypothetical protein 0.0334 0.0645 0.0827
Loa Loa (eye worm) hypothetical protein 0.0285 0.0503 0.0644
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0217 0.0304 0.1535
Brugia malayi map kinase activated protein kinase protein 2 0.1139 0.3 0.3865
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.053 0.1218 0.175
Schistosoma mansoni tyrosine kinase 0.1059 0.2768 0.5681
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0187 0.0217 0.1081
Onchocerca volvulus 0.0189 0.0221 0.0424
Loa Loa (eye worm) AGC/NDR protein kinase 0.0419 0.0894 0.1148
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0441 0.0958 0.4956
Loa Loa (eye worm) hypothetical protein 0.0463 0.1022 0.1313
Leishmania major protein kinase A catalytic subunit isoform 1 0.0225 0.0328 0.1662
Onchocerca volvulus 0.015 0.0108 0.0204
Echinococcus granulosus raf serine:threonine protein kinase 0.0211 0.0284 0.0281
Trichomonas vaginalis CAMK family protein kinase 0.0307 0.0568 0.2742
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0225 0.0328 0.1662
Loa Loa (eye worm) AGC/PKA protein kinase 0.0225 0.0328 0.0418
Loa Loa (eye worm) hypothetical protein 0.0273 0.0468 0.0599
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0225 0.0328 0.1581
Loa Loa (eye worm) TK/FER protein kinase 0.0189 0.0221 0.0281
Brugia malayi Protein kinase domain containing protein 0.0528 0.1212 0.1558
Onchocerca volvulus 0.0189 0.0221 0.0424
Trichomonas vaginalis STE family protein kinase 0.0224 0.0323 0.1524
Echinococcus multilocularis aurora kinase A 0.04 0.084 0.1205
Leishmania major protein kinase A catalytic subunit isoform 2 0.0225 0.0328 0.1662
Echinococcus granulosus casein kinase i 0.0217 0.0302 0.0299
Schistosoma mansoni cell adhesion molecule 0.0127 0.0039 0.008
Echinococcus granulosus casein kinase I alpha 0.0217 0.0302 0.0299
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0422 0.0904 0.1297
Entamoeba histolytica protein kinase, putative 0.0331 0.0638 0.3123
Loa Loa (eye worm) hypothetical protein 0.0304 0.0557 0.0714
Loa Loa (eye worm) TK/ROR protein kinase 0.0156 0.0124 0.0155
Brugia malayi Protein kinase domain containing protein 0.0635 0.1526 0.1964
Schistosoma mansoni tyrosine kinase 0.0189 0.0221 0.0454
Giardia lamblia Kinase, CMGC DYRK 0.012 0.0018 0.0044
Echinococcus multilocularis protein kinase shaggy 0.035 0.0694 0.0994
Echinococcus granulosus serine:threonine protein kinase 3 0.0731 0.1807 0.1804
Trypanosoma brucei cdc2-related kinase 1 0.0321 0.0608 0.2975
Loa Loa (eye worm) hypothetical protein 0.0167 0.0158 0.0199
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0168 0.0161 0.0226
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.022 0.0312 0.15
Echinococcus granulosus nervana 2 0.0367 0.0743 0.0739
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0217 0.0304 0.1535
Brugia malayi C1-like domain containing protein 0.0479 0.1071 0.1376
Echinococcus granulosus twitchin 0.0394 0.0821 0.0818
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0316 0.0593 0.076
Leishmania major protein kinase, putative 0.0187 0.0217 0.1081
Toxoplasma gondii CMGC kinase, CK2 family 0.0266 0.0446 0.2252
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0131 0.0051 0.0164
Schistosoma mansoni serine/threonine protein kinase 0.0453 0.0993 0.2039
Echinococcus granulosus titin 0.0133 0.0057 0.0053
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.022 0.0312 0.1577
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0198 0.0247 0.0314
Echinococcus granulosus epidermal growth factor receptor 0.1161 0.3064 0.3062
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0179 0.0192 0.0271
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0179 0.0192 0.2018
Entamoeba histolytica hypothetical protein 0.0381 0.0783 0.3845
Echinococcus granulosus c-Jun N-terminal kinases 0.0753 0.1872 0.1869
Brugia malayi Protein kinase domain containing protein 0.0371 0.0754 0.0968
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0363 0.0731 0.0727
Giardia lamblia Kinase, CK1 Casein kinase 0.0217 0.0302 0.1529
Onchocerca volvulus 0.0189 0.0221 0.0424
Loa Loa (eye worm) AGC/PKN protein kinase 0.0549 0.1274 0.1639
Trichomonas vaginalis CAMK family protein kinase 0.0771 0.1924 0.9511
Schistosoma mansoni tyrosine kinase 0.0434 0.0938 0.1925
Schistosoma mansoni protein kinase 0.0629 0.151 0.3098
Loa Loa (eye worm) hypothetical protein 0.0222 0.0319 0.0407
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0433 0.0937 0.1344
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0629 0.151 0.1506
Loa Loa (eye worm) hypothetical protein 0.0413 0.0877 0.1126
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0452 0.0991 0.5124
Trypanosoma cruzi p21-activated kinase 3, putative 0.0131 0.0051 0.0216
Loa Loa (eye worm) hypothetical protein 0.0182 0.0202 0.0256
Trichomonas vaginalis CAMK family protein kinase 0.0771 0.1924 0.9511
Echinococcus multilocularis dual specificity 0.012 0.0018 0.0021
Schistosoma mansoni kinase 0.0826 0.2084 0.4277
Plasmodium falciparum calcium-dependent protein kinase 1 0.0179 0.0192 0.2018
Echinococcus multilocularis dual specificity 0.012 0.0018 0.0021
Trichomonas vaginalis CAMK family protein kinase 0.0771 0.1924 0.9511
Echinococcus granulosus serine:threonine protein kinase MARK2 0.053 0.1218 0.1215
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0225 0.0328 0.0324
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0159 0.0134 0.0187
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0363 0.0731 0.1047
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0529 0.1216 0.1747
Echinococcus multilocularis protein tyrosine kinase 0.0609 0.145 0.2083
Echinococcus multilocularis serine:threonine protein kinase N2 0.0549 0.1274 0.1831
Trypanosoma brucei rac serine-threonine kinase, putative 0.0804 0.2022 1
Entamoeba histolytica protein kinase, putative 0.0178 0.0189 0.089
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0131 0.0051 0.0061
Onchocerca volvulus 0.0431 0.093 0.1807
Trichomonas vaginalis AGC family protein kinase 0.021 0.0284 0.1327
Loa Loa (eye worm) hypothetical protein 0.0157 0.0129 0.0162
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.012 0.0018 0.0074
Trypanosoma cruzi casein kinase, putative 0.0217 0.0302 0.1529
Schistosoma mansoni protein kinase 0.032 0.0605 0.1242
Onchocerca volvulus 0.0412 0.0874 0.1697
Schistosoma mansoni roundabout 0.0115 0.0004 0.0008
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0187 0.0217 0.1081
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.035 0.0694 0.3575
Echinococcus multilocularis death associated protein kinase 1 0.2487 0.6945 1
Echinococcus granulosus cGMP dependent protein kinase 1 0.0168 0.0161 0.0157
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.0215 0.0442
Trichomonas vaginalis STE family protein kinase 0.022 0.0312 0.1465
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.0104 0.0426
Entamoeba histolytica cell division protein kinase 2, putative 0.0321 0.0608 0.2975
Entamoeba histolytica protein kinase, putative 0.0178 0.0189 0.089
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0334 0.0647 0.3329
Echinococcus granulosus Immunoglobulin 0.0273 0.0468 0.0465
Schistosoma mansoni tyrosine kinase 0.0216 0.03 0.0616
Trichomonas vaginalis AGC family protein kinase 0.0804 0.2022 1
Echinococcus multilocularis 0.0187 0.0215 0.0305
Loa Loa (eye worm) hypothetical protein 0.0431 0.093 0.1195
Loa Loa (eye worm) hypothetical protein 0.0412 0.0874 0.1122
Onchocerca volvulus 0.0133 0.0057 0.0103
Schistosoma mansoni hypothetical protein 0.0222 0.0319 0.0655
Echinococcus granulosus cGMP dependent protein kinase 1 0.0168 0.0161 0.0157
Schistosoma mansoni serine/threonine protein kinase 0.0167 0.0158 0.0324
Schistosoma mansoni serine/threonine protein kinase 0.0934 0.24 0.4926
Echinococcus multilocularis 0.0516 0.1177 0.169
Schistosoma mansoni atypical protein kinase C 0.0792 0.1986 0.4077
Loa Loa (eye worm) hypothetical protein 0.0412 0.0874 0.1122
Schistosoma mansoni tyrosine kinase 0.026 0.0429 0.088
Brugia malayi hypothetical protein 0.0182 0.0202 0.0256
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0273 0.0468 0.0961
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0168 0.0159 0.0791
Echinococcus granulosus c src tyrosine kinase 0.026 0.0429 0.0425
Echinococcus granulosus dual specificity 0.012 0.0018 0.0015
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0236 0.036 0.0357
Schistosoma mansoni protein kinase 0.0629 0.151 0.3098
Trichomonas vaginalis AGC family protein kinase 0.0804 0.2022 1
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0541 0.1251 0.1247
Trichomonas vaginalis AGC family protein kinase 0.0804 0.2022 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0217 0.0304 0.1535
Trichomonas vaginalis CMGC family protein kinase 0.0266 0.0446 0.2135
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0786 0.1968 0.2533
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0187 0.0217 0.1028
Echinococcus multilocularis epidermal growth factor receptor 0.1161 0.3064 0.441
Entamoeba histolytica protein kinase, putative 0.0224 0.0323 0.1559
Trichomonas vaginalis CK1 family protein kinase 0.0217 0.0302 0.1419
Echinococcus multilocularis casein kinase ii subunit alpha 0.0266 0.0446 0.0637
Giardia lamblia Kinase, STE STE20 0.0224 0.0323 0.1639
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.044 0.0955 0.1227
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.022 0.0312 0.15
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.035 0.0694 0.3575
Trichomonas vaginalis AGC family protein kinase 0.0804 0.2022 1
Entamoeba histolytica protein kinase domain containing protein 0.0236 0.036 0.1743
Loa Loa (eye worm) AGC/PKG protein kinase 0.0168 0.0161 0.0203
Echinococcus granulosus protein tyrosine kinase 0.0609 0.145 0.1447
Schistosoma mansoni tyrosine kinase 0.0585 0.138 0.2832
Plasmodium falciparum protein kinase 5 0.0321 0.0608 0.648
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0197 0.0244 0.0502
Schistosoma mansoni serine/threonine protein kinase 0.0289 0.0514 0.1055
Echinococcus granulosus mitogen activated protein kinase 0.0217 0.0304 0.03
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.012 0.0018 0.0019
Onchocerca volvulus 0.0189 0.0221 0.0424
Brugia malayi Protein kinase domain containing protein 0.0189 0.0221 0.0281
Giardia lamblia Kinase, CMGC CDK 0.0321 0.0608 0.3127
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0419 0.0894 0.1283
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0541 0.1251 0.1608
Echinococcus multilocularis expressed protein 0.0117 0.001 0.0009
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.035 0.0694 0.3514
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0167 0.0158 0.0775
Loa Loa (eye worm) hypothetical protein 0.0255 0.0414 0.0529
Echinococcus multilocularis insulin receptor 0.1296 0.346 0.498
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0217 0.0302 0.0385
Loa Loa (eye worm) AGC/PKA protein kinase 0.0225 0.0328 0.0418
Leishmania major protein kinase, putative 0.04 0.084 0.4338
Trypanosoma cruzi Protein kinase B 0.0452 0.0991 0.5124
Loa Loa (eye worm) hypothetical protein 0.0133 0.0059 0.0071
Echinococcus multilocularis serine:threonine protein kinase N2 0.0419 0.0894 0.1283
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0197 0.0244 0.0502
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0225 0.0328 0.0324
Entamoeba histolytica PH domain containing protein kinase, putative 0.0452 0.0991 0.4875
Brugia malayi Immunoglobulin I-set domain containing protein 0.0133 0.0057 0.0068
Brugia malayi Protein kinase domain containing protein 0.0541 0.1251 0.1608
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0167 0.0158 0.0775
Schistosoma mansoni tyrosine kinase 0.0194 0.0237 0.0487
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0434 0.0938 0.0935
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0771 0.1924 0.2476
Schistosoma mansoni serine/threonine protein kinase 0.0753 0.1872 0.3841
Brugia malayi Variant SH3 domain containing protein 0.0159 0.0132 0.0166
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0197 0.0244 0.0311
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0453 0.0993 0.099
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0225 0.0328 0.0467
Trichomonas vaginalis AGC family protein kinase 0.0419 0.0894 0.4371
Echinococcus granulosus NDR protein kinase 0.0419 0.0894 0.0891
Echinococcus multilocularis mitogen activated protein kinase 0.0217 0.0304 0.0432
Echinococcus granulosus MAP kinase activated protein kinase 2 0.1139 0.3 0.2998
Echinococcus granulosus serine:threonine protein kinase N2 0.013 0.0049 0.0045
Trichomonas vaginalis CMGC family protein kinase 0.0321 0.0608 0.2945
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.0418 0.0858
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.0104 0.0426
Echinococcus granulosus casein kinase I delta 0.0217 0.0302 0.0299
Brugia malayi Sex muscle abnormal protein 5 0.0159 0.0132 0.0166
Schistosoma mansoni serine/threonine kinase 0.0419 0.0894 0.1835
Brugia malayi Immunoglobulin I-set domain containing protein 0.0285 0.0503 0.0644
Schistosoma mansoni serine/threonine protein kinase 0.0289 0.0513 0.1053
Loa Loa (eye worm) hypothetical protein 0.0285 0.0503 0.0644
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0179 0.0192 0.0188
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1308 0.3495 0.3493
Schistosoma mansoni serine/threonine protein kinase 0.0265 0.0445 0.0913
Trichomonas vaginalis CAMK family protein kinase 0.0167 0.0158 0.0698
Trichomonas vaginalis CMGC family protein kinase 0.035 0.0694 0.3373
Plasmodium falciparum glycogen synthase kinase 3 0.035 0.0694 0.7398
Schistosoma mansoni tyrosine kinase 0.0434 0.0938 0.1925
Loa Loa (eye worm) TK/FER protein kinase 0.0189 0.0221 0.0281
Brugia malayi Doublecortin family protein 0.0185 0.0208 0.0264
Loa Loa (eye worm) hypothetical protein 0.0388 0.0803 0.1032
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0331 0.0638 0.3283
Schistosoma mansoni serine/threonine protein kinase 0.0289 0.0513 0.1053
Brugia malayi protein unc-22 0.0133 0.0057 0.0068
Brugia malayi Serine/threonine-protein kinase SULU 0.0256 0.0418 0.0534
Echinococcus multilocularis NCK adaptor protein 0.0159 0.0132 0.0185
Loa Loa (eye worm) hypothetical protein 0.0133 0.0059 0.0071
Giardia lamblia Kinase, AGC PKA 0.0433 0.0937 0.4843
Echinococcus granulosus contactin 0.0127 0.0039 0.0035
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0373 0.0759 0.3845
Trypanosoma cruzi cdc2-related kinase 1 0.0321 0.0608 0.3127
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0131 0.0051 0.0061
Giardia lamblia Kinase, CMGC CK2 0.0266 0.0446 0.2279
Entamoeba histolytica PH domain containing protein kinase, putative 0.0244 0.0382 0.1848
Echinococcus granulosus mitogen activated protein kinase 3 0.0217 0.0304 0.03
Giardia lamblia Kinase, PLK 0.0771 0.1924 1
Schistosoma mansoni tyrosine kinase 0.069 0.1687 0.3462
Echinococcus multilocularis tyrosine protein kinase Blk 0.0363 0.0731 0.1047
Echinococcus granulosus defective proboscis extension response 0.0273 0.0468 0.0465
Schistosoma mansoni titin 0.0115 0.0004 0.0008
Echinococcus granulosus RNA directed DNA polymerase 0.0118 0.0013 0.0009
Echinococcus granulosus roundabout 2 0.0127 0.0039 0.0035
Leishmania major protein kinase, putative 0.0179 0.0192 0.0952
Schistosoma mansoni growth factor receptor-bound protein 0.0159 0.0132 0.0271
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0179 0.0192 0.0188
Brugia malayi putative serine/threonine kinase SADA gamma 0.0167 0.0158 0.0199
Brugia malayi Protein kinase domain containing protein 0.0189 0.0221 0.0281
Echinococcus multilocularis tyrosine protein kinase HCK 0.0275 0.0474 0.0678
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0179 0.0192 0.2018
Entamoeba histolytica protein kinase, putative 0.0804 0.2022 1
Echinococcus granulosus CDC7 cell division cycle 7 0.0123 0.0029 0.0026
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0197 0.0244 0.0241
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0564 0.132 0.1317
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0225 0.0328 0.1662
Echinococcus granulosus rho-associated protein kinase 1 0.0934 0.24 0.2397
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0198 0.0247 0.0244
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0805 0.2023 0.2909
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0127 0.0039 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0371 0.0754 0.3673
Plasmodium falciparum protein kinase, putative 0.0168 0.0159 0.1666
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0225 0.0328 0.0467
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0334 0.0646 0.0828
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0367 0.0743 0.0739
Echinococcus multilocularis roundabout 2 0.0127 0.0039 0.0051
Trypanosoma cruzi casein kinase, putative 0.0217 0.0302 0.1529
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0321 0.0608 0.0605
Brugia malayi ephrin receptor 1 precursor 0.0191 0.0227 0.0288
Schistosoma mansoni protein kinase 0.0266 0.0446 0.0915
Schistosoma mansoni nck2/grb4 0.0159 0.0132 0.0271
Trypanosoma cruzi casein kinase, delta isoform, putative 0.015 0.0108 0.0515
Echinococcus granulosus fibroblast growth factor receptor 4 0.069 0.1687 0.1684
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0149 0.0104 0.01
Onchocerca volvulus 0.1712 0.4677 0.9112
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.022 0.0312 0.15
Entamoeba histolytica protein kinase, putative 0.0786 0.1968 0.9732
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0564 0.132 0.1896
Schistosoma mansoni serine/threonine protein kinase 0.0565 0.132 0.2709
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0159 0.0132 0.0271
Echinococcus granulosus tyrosine protein kinase Srms 0.0189 0.0221 0.0218
Loa Loa (eye worm) hypothetical protein 0.0307 0.0568 0.0727
Schistosoma mansoni vesicular amine transporter 0.0273 0.0468 0.0961
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.021 0.0284 0.0362
Plasmodium falciparum calcium-dependent protein kinase 3 0.0179 0.0192 0.2018
Brugia malayi Protein kinase domain containing protein 0.0804 0.2022 0.2603
Loa Loa (eye worm) hypothetical protein 0.0115 0.0006 0.0002
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0179 0.0192 0.0188
Onchocerca volvulus 0.0123 0.0029 0.005
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0419 0.0894 0.0891
Loa Loa (eye worm) hypothetical protein 0.0179 0.0192 0.0243
Schistosoma mansoni tyrosine kinase 0.1779 0.4872 1
Brugia malayi Fibronectin type III domain containing protein 0.0285 0.0503 0.0644
Loa Loa (eye worm) hypothetical protein 0.0521 0.1193 0.1534
Echinococcus granulosus aurora kinase A 0.04 0.084 0.0837
Trypanosoma cruzi cdc2-related kinase 3 0.0321 0.0608 0.3127
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0225 0.0328 0.0418
Giardia lamblia Kinase, CMGC GSK 0.035 0.0694 0.3575
Echinococcus multilocularis nervana 2 0.0367 0.0743 0.1065
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0398 0.0834 0.0831
Giardia lamblia Kinase, CMGC CLK 0.0187 0.0217 0.1081
Schistosoma mansoni serine/threonine protein kinase 0.0211 0.0284 0.0584
Loa Loa (eye worm) hypothetical protein 0.0265 0.0444 0.0568
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0321 0.0608 0.3127
Onchocerca volvulus 0.0189 0.0221 0.0424
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0439 0.0954 0.1225
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0373 0.076 0.3701
Echinococcus granulosus casein kinase I alpha 0.0217 0.0302 0.0299
Entamoeba histolytica casein kinase, putative 0.0266 0.0446 0.2168
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0188 0.0218 0.0276
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0185 0.0208 0.0264
Giardia lamblia Kinase, AGC PKA 0.0225 0.0328 0.1662
Onchocerca volvulus 0.0133 0.0059 0.0107
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0307 0.0568 0.0727
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.04 0.084 0.4126
Echinococcus multilocularis titin 0.0133 0.0057 0.0076
Echinococcus multilocularis neuroglian 0.0328 0.0627 0.0898
Echinococcus granulosus casein kinase I alpha 0.0217 0.0302 0.0299
Echinococcus granulosus tyrosine protein kinase Fyn 0.0434 0.0938 0.0935
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0179 0.0192 0.0905
Echinococcus granulosus casein kinase I delta 0.0217 0.0302 0.0299
Plasmodium vivax glycogen synthase kinase 3, putative 0.035 0.0694 0.7398
Echinococcus granulosus serine/threonine protein kinase 0.0452 0.0991 0.0987
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0127 0.0039 0.0051
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0179 0.0192 0.0188
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0133 0.0059 0.0242
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0159 0.0134 0.013
Brugia malayi P38 map kinase family protein 2 0.0441 0.0958 0.1231
Schistosoma mansoni tyrosine kinase 0.1161 0.3064 0.6289
Schistosoma mansoni nephrin 0.034 0.0662 0.1359
Echinococcus multilocularis serine threonine protein kinase 0.054 0.1249 0.1795
Schistosoma mansoni neuroglian 0.0127 0.0039 0.008
Entamoeba histolytica protein kinase, putative 0.0154 0.0119 0.0543
Echinococcus multilocularis tyrosine kinase 0.0189 0.0221 0.0314
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.021 0.0284 0.0404
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0771 0.1924 0.1921
Schistosoma mansoni serine/threonine protein kinase 0.1139 0.3 0.6157
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.069 0.1687 0.2425
Echinococcus granulosus microtubule associated protein 2 0.0833 0.2107 0.2104
Echinococcus multilocularis myotubularin protein 13 0.0128 0.0042 0.0055
Echinococcus multilocularis roundabout 2 0.0127 0.0039 0.0051
Echinococcus multilocularis CDC7 cell division cycle 7 0.0123 0.0029 0.0037
Brugia malayi hypothetical protein 0.0256 0.0418 0.0534
Echinococcus multilocularis peroxidasin 0.0115 0.0006 0.0003
Entamoeba histolytica serine/threonine protein kinase, putative 0.0167 0.0158 0.0737
Schistosoma mansoni serine/threonine protein kinase 0.053 0.1218 0.25
Echinococcus granulosus casein kinase I gamma 0.0187 0.0215 0.0212
Loa Loa (eye worm) TK/FER protein kinase 0.0189 0.0221 0.0281
Schistosoma mansoni serine/threonine protein kinase 0.065 0.1569 0.322
Giardia lamblia Kinase, NEK 0.0373 0.0759 0.3914
Schistosoma mansoni protein kinase 0.0513 0.1169 0.2399
Brugia malayi Protein kinase domain containing protein 0.021 0.0284 0.0362
Brugia malayi Protein kinase domain containing protein 0.0321 0.0608 0.078
Echinococcus granulosus serine:threonine protein kinase N2 0.0549 0.1274 0.1271
Brugia malayi Casein kinase II, alpha chain 0.0266 0.0446 0.057
Schistosoma mansoni serine/threonine protein kinase 0.0236 0.036 0.074
Loa Loa (eye worm) hypothetical protein 0.0265 0.0444 0.0568
Schistosoma mansoni tyrosine kinase 0.1296 0.346 0.7102
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0541 0.1251 0.1608
Plasmodium vivax casein kinase 1, putative 0.0217 0.0302 0.3202
Loa Loa (eye worm) SRC-1 0.0434 0.0938 0.1205
Loa Loa (eye worm) TK/FER protein kinase 0.0189 0.0221 0.0281
Echinococcus granulosus protein kinase shaggy 0.035 0.0694 0.0691
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.035 0.0694 0.0994
Plasmodium falciparum serine/threonine protein kinase, putative 0.04 0.084 0.8963
Brugia malayi Protein kinase domain containing protein 0.0198 0.0247 0.0314
Schistosoma mansoni serine/threonine kinase 0.0371 0.0754 0.1548
Brugia malayi Protein kinase domain containing protein 0.0331 0.0638 0.0818
Entamoeba histolytica serine/threonine protein kinase, putative 0.0771 0.1924 0.9513
Loa Loa (eye worm) TK/FER protein kinase 0.0189 0.0221 0.0281
Echinococcus multilocularis serine:threonine protein kinase N2 0.013 0.0049 0.0065
Schistosoma mansoni protein kinase 0.04 0.084 0.1724
Entamoeba histolytica protein kinase , putative 0.04 0.084 0.4126
Trypanosoma cruzi polo-like protein kinase, putative 0.0771 0.1924 1
Schistosoma mansoni serine/threonine protein kinase 0.0669 0.1624 0.3334
Brugia malayi Protein kinase domain containing protein 0.0422 0.0904 0.1161
Echinococcus granulosus tyrosine protein kinase Src42A 0.0262 0.0434 0.0431
Leishmania major casein kinase, putative 0.0217 0.0302 0.1529
Brugia malayi Protein kinase domain containing protein 0.0635 0.1526 0.1964
Entamoeba histolytica protein kinase, putative 0.0179 0.0192 0.0905
Loa Loa (eye worm) hypothetical protein 0.0274 0.047 0.0602
Brugia malayi serine/threonine protein kinase 6 0.04 0.084 0.1079
Echinococcus granulosus tyrosine protein kinase Src42A 0.0434 0.0938 0.0935
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0483 0.1082 0.139
Schistosoma mansoni serine/threonine protein kinase 0.0131 0.0051 0.0105
Echinococcus granulosus roundabout 2 0.04 0.0839 0.0835
Trichomonas vaginalis CAMK family protein kinase 0.0167 0.0158 0.0698
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.0192 0.0393
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0331 0.0638 0.3123
Trichomonas vaginalis AGC family protein kinase 0.04 0.084 0.4102
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0127 0.0039 0.0035
Brugia malayi Immunoglobulin I-set domain containing protein 0.2147 0.5949 0.7668
Plasmodium falciparum cGMP-dependent protein kinase 0.0168 0.0161 0.1685
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0224 0.0323 0.0461
Schistosoma mansoni cell adhesion molecule 0.0346 0.068 0.1395
Trichomonas vaginalis CAMK family protein kinase 0.0771 0.1924 0.9511
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0224 0.0323 0.0461
Trichomonas vaginalis AGC family protein kinase 0.0804 0.2022 1
Trichomonas vaginalis CAMK family protein kinase 0.0167 0.0158 0.0698
Trichomonas vaginalis CAMK family protein kinase 0.0771 0.1924 0.9511
Schistosoma mansoni protein kinase 0.0168 0.0159 0.0327
Echinococcus granulosus activin receptor type 0.0168 0.0159 0.0155
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0434 0.0938 0.1346
Plasmodium vivax protein kinase Crk2 0.0321 0.0608 0.648
Brugia malayi p70 ribosomal S6 kinase beta 0.0786 0.1968 0.2533
Echinococcus multilocularis dual specificity protein kinase clk2 0.0187 0.0217 0.0307
Leishmania major protein kinase A catalytic subunit 0.0225 0.0328 0.1662
Echinococcus granulosus titin 0.0133 0.0057 0.0053
Echinococcus granulosus dual specificity 0.012 0.0018 0.0015
Onchocerca volvulus 0.0413 0.0877 0.1702
Echinococcus multilocularis Immunoglobulin 0.0273 0.0468 0.0669
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0433 0.0937 1
Brugia malayi protein kinase C3,putative 0.0422 0.0902 0.1159
Echinococcus granulosus N chimaerin 0.0197 0.0244 0.0241
Brugia malayi Protein kinase domain containing protein 0.0529 0.1215 0.1563
Echinococcus multilocularis N chimaerin 0.0197 0.0244 0.0347
Giardia lamblia Kinase, CAMK CAMKL 0.0167 0.0158 0.0775
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0159 0.0132 0.0166
Schistosoma mansoni serine/threonine protein kinase 0.0131 0.0051 0.0105
Brugia malayi Protein kinase domain containing protein 0.0439 0.0954 0.1225
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0629 0.151 0.217
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0373 0.0759 0.8093
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0331 0.0638 0.3283
Entamoeba histolytica PH domain containing protein kinase, putative 0.0244 0.0382 0.1848
Trichomonas vaginalis CMGC family protein kinase 0.0266 0.0446 0.2135
Trypanosoma cruzi polo-like protein kinase, putative 0.0771 0.1924 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0217 0.0304 0.0432
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0334 0.0645 0.0641
Onchocerca volvulus 0.0934 0.24 0.4673
Trichomonas vaginalis CAMK family protein kinase 0.0179 0.0192 0.0867
Brugia malayi Cam kinase protein 1 0.0179 0.0192 0.0243
Echinococcus multilocularis serine:threonine protein kinase 3 0.0731 0.1807 0.2598
Echinococcus granulosus tyrosine protein kinase Blk 0.0363 0.0731 0.0727
Loa Loa (eye worm) TK/EPH protein kinase 0.0343 0.0673 0.0864
Brugia malayi Pleckstrin Homology Domain 0.0128 0.0042 0.0049
Loa Loa (eye worm) hypothetical protein 0.0254 0.0411 0.0525
Brugia malayi Protein kinase domain containing protein 0.0565 0.132 0.1698
Brugia malayi Protein kinase domain containing protein 0.0187 0.0217 0.0275
Brugia malayi Tyrosine-protein kinase abl-1 0.0495 0.1117 0.1436
Echinococcus granulosus tyrosine protein kinase Fyn 0.0434 0.0938 0.0935
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.2107 0.4323
Schistosoma mansoni serine/threonine protein kinase 0.0225 0.0328 0.0673
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0225 0.0328 0.1662
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0434 0.0938 0.1346
Echinococcus granulosus peroxidasin 0.0115 0.0006 0.0002
Echinococcus multilocularis Protein kinase C, brain isozyme 0.065 0.1569 0.2255
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0197 0.0244 0.0347
Onchocerca volvulus Serine\/threonine kinase homolog 0.0771 0.1924 0.3744
Echinococcus granulosus NCK adaptor protein 0.0159 0.0132 0.0129
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0159 0.0132 0.0166
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0669 0.1624 0.209
Leishmania major protein kinase, putative 0.0168 0.0159 0.078
Echinococcus multilocularis nervana 2 0.0367 0.0743 0.1065
Echinococcus granulosus roundabout 2 0.0127 0.0039 0.0035
Brugia malayi Protein kinase domain containing protein 0.1296 0.346 0.4458
Echinococcus multilocularis roundabout 2 0.04 0.0839 0.1203
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0433 0.0937 0.0933
Echinococcus granulosus mitogen activated protein kinase 14 0.0441 0.0958 0.0955
Schistosoma mansoni protein kinase C mu 0.0479 0.1071 0.2197
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0133 0.0059 0.0255
Brugia malayi hypothetical protein 0.0285 0.0503 0.0644
Schistosoma mansoni protein kinase 0.0422 0.0904 0.1856
Brugia malayi SH2 domain containing protein 0.0189 0.0221 0.0281
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0321 0.0608 0.078
Loa Loa (eye worm) TK protein kinase 0.0744 0.1846 0.2376
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.0302 0.0621
Schistosoma mansoni serine/threonine protein kinase 0.0331 0.0638 0.131
Entamoeba histolytica protein kinase, putative 0.021 0.0284 0.1363
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0168 0.0159 0.078
Echinococcus granulosus glycogen synthase kinase 3 beta 0.035 0.0694 0.0691
Trichomonas vaginalis CAMK family protein kinase 0.0167 0.0158 0.0698
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0334 0.0646 0.0828
Loa Loa (eye worm) hypothetical protein 0.0159 0.0132 0.0166
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0225 0.0328 0.3474
Trichomonas vaginalis CAMK family protein kinase 0.0167 0.0158 0.0698
Schistosoma mansoni serine/threonine protein kinase 0.0289 0.0513 0.1053
Schistosoma mansoni serine/threonine-protein kinase 0.0452 0.0991 0.2033
Entamoeba histolytica protein kinase domain containing protein 0.0266 0.0446 0.2168
Schistosoma mansoni tyrosine kinase 0.026 0.0429 0.088
Loa Loa (eye worm) hypothetical protein 0.0225 0.0328 0.0418
Loa Loa (eye worm) TK protein kinase 0.0363 0.0731 0.0938
Schistosoma mansoni protein kinase 0.0227 0.0332 0.0681
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0133 0.0059 0.0255
Entamoeba histolytica protein kinase domain containing protein 0.035 0.0694 0.34
Leishmania major protein kinase, putative 0.0187 0.0217 0.1081
Echinococcus granulosus tyrosine protein kinase Fyn 0.0434 0.0938 0.0935
Brugia malayi Variant SH3 domain containing protein 0.0159 0.0132 0.0166
Loa Loa (eye worm) CMGC/GSK protein kinase 0.035 0.0694 0.089
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0156 0.0124 0.012
Echinococcus multilocularis casein kinase I delta 0.0217 0.0302 0.043
Echinococcus multilocularis calcium activated potassium channel 0.0289 0.0513 0.0734
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0453 0.0993 0.1426
Brugia malayi Variant SH3 domain containing protein 0.0197 0.0244 0.0311
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0513 0.1169 0.1166
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.0217 0.0445
Loa Loa (eye worm) TK/FER protein kinase 0.0189 0.0221 0.0281
Onchocerca volvulus 0.035 0.0694 0.1346
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.021 0.0284 0.0362
Echinococcus multilocularis epidermal growth factor receptor 0.1779 0.4872 0.7014
Brugia malayi Fes/CIP4 homology domain containing protein 0.0143 0.0086 0.0107
Brugia malayi serine/threonine-protein kinase PAK 7 0.0658 0.1592 0.2049
Echinococcus multilocularis serine:threonine protein kinase 0.0307 0.0568 0.0812
Loa Loa (eye worm) CDC7 protein kinase 0.0123 0.0029 0.0033
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0189 0.0221 0.0218
Echinococcus multilocularis casein kinase I alpha 0.0217 0.0302 0.043
Schistosoma mansoni serine/threonine protein kinase 0.065 0.1569 0.322
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0179 0.0192 0.0271
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0434 0.0938 0.1346
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0453 0.0995 0.1279
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.04 0.084 0.4126
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0236 0.036 0.046
Echinococcus granulosus tyrosine kinase 0.0363 0.0731 0.0727
Plasmodium vivax unspecified product 0.0266 0.0446 0.474
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0225 0.0328 0.0324
Echinococcus granulosus dual specificity 0.012 0.0018 0.0015
Entamoeba histolytica p21-activated kinase 0.0242 0.0377 0.1827
Plasmodium falciparum calcium-dependent protein kinase 4 0.0179 0.0192 0.2018
Schistosoma mansoni tyrosine kinase 0.1059 0.2768 0.5681
Trypanosoma cruzi aurora B kinase, putative 0.04 0.084 0.4338
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0273 0.0468 0.0669
Trypanosoma brucei protein kinase, putative 0.0217 0.0304 0.1461
Entamoeba histolytica protein kinase domain containing protein 0.04 0.084 0.4126
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0434 0.0938 0.1346
Trichomonas vaginalis CAMK family protein kinase 0.0167 0.0158 0.0698
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0367 0.0743 0.1065
Echinococcus granulosus calcium activated potassium channel 0.0289 0.0513 0.051
Echinococcus granulosus Vam6:Vps39 protein 0.0133 0.0059 0.0055
Toxoplasma gondii casein kinase I 0.0217 0.0302 0.1521
Schistosoma mansoni serine/threonine protein kinase 0.012 0.0018 0.0037
Loa Loa (eye worm) hypothetical protein 0.0426 0.0915 0.1176
Trypanosoma brucei casein kinase I, isoform 2 0.0217 0.0302 0.1455
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.0057 0.0116
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.053 0.1218 0.175
Plasmodium falciparum protein serine/threonine kinase-1 0.0187 0.0217 0.2283
Trypanosoma brucei Casein kinase II 0.0266 0.0446 0.2168
Trypanosoma cruzi casein kinase, putative 0.0217 0.0302 0.1529
Entamoeba histolytica protein kinase, putative 0.0179 0.0192 0.0904
Schistosoma mansoni protein kinase 0.0224 0.0323 0.0664
Loa Loa (eye worm) TK/FER protein kinase 0.0189 0.0221 0.0281
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0179 0.0192 0.0243
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0434 0.0938 0.1346
Loa Loa (eye worm) thyroid receptor interactor 0.0143 0.0086 0.0107
Toxoplasma gondii histone kinase SNF1, putative 0.0167 0.0158 0.0786
Loa Loa (eye worm) CMGC/GSK protein kinase 0.035 0.0694 0.089
Schistosoma mansoni hypothetical protein 0.0133 0.0059 0.012
Echinococcus multilocularis expressed conserved protein 0.0168 0.0161 0.0226
Echinococcus granulosus cyclin dependent kinase 0.0321 0.0608 0.0605
Entamoeba histolytica casein kinase, putative 0.0217 0.0302 0.1455
Brugia malayi serine/threonine-protein kinase plk-2 0.0771 0.1924 0.2476
Brugia malayi Egg laying defective protein 4 0.0168 0.0161 0.0203
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0217 0.0304 0.0387
Loa Loa (eye worm) TK/ABL protein kinase 0.0805 0.2023 0.2604
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0179 0.0192 0.2018
Schistosoma mansoni serine/threonine protein kinase 0.0453 0.0993 0.2039
Loa Loa (eye worm) hypothetical protein 0.0121 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.0831 0.2099 0.2703
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.04 0.084 0.1205
Brugia malayi SRC-1 0.0434 0.0938 0.1205
Loa Loa (eye worm) TK/FER protein kinase 0.0189 0.0221 0.0281
Giardia lamblia Kinase, NEK 0.0373 0.0759 0.3914
Trichomonas vaginalis STE family protein kinase 0.0224 0.0323 0.1524
Trichomonas vaginalis AGC family protein kinase 0.0804 0.2022 1
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.012 0.0018 0.0044
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0771 0.1924 0.2766
Trichomonas vaginalis CMGC family protein kinase 0.0187 0.0217 0.0991
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.1139 0.3 0.4317
Plasmodium vivax serine/threonine kinase-1, putative 0.0187 0.0217 0.2283
Leishmania major protein kinase, putative 0.022 0.0312 0.1577
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0669 0.1624 0.1621
Trichomonas vaginalis CAMK family protein kinase 0.0167 0.0158 0.0698
Echinococcus multilocularis cyclin dependent kinase 0.0321 0.0608 0.0871
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0331 0.0638 0.3283
Brugia malayi Protein kinase c protein 2 0.0297 0.0538 0.0689
Loa Loa (eye worm) AGC/AKT protein kinase 0.0804 0.2022 0.2603
Loa Loa (eye worm) hypothetical protein 0.0227 0.0332 0.0424
Echinococcus granulosus expressed protein 0.0117 0.001 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.04 0.084 0.1724
Brugia malayi hypothetical protein 0.0133 0.0059 0.0071
Echinococcus granulosus neuroglian 0.0127 0.0039 0.0035
Trypanosoma brucei protein kinase, putative 0.0168 0.0159 0.0742
Schistosoma mansoni ste20-related kinase 0.0577 0.1358 0.2787
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.012 0.0018 0.0042
Echinococcus granulosus tyrosine protein kinase Lyn 0.05 0.1132 0.1129
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0225 0.0328 0.1662
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.012 0.0018 0.0044
Echinococcus multilocularis cyclin dependent kinase 1 0.0321 0.0608 0.0871
Entamoeba histolytica protein kinase, putative 0.012 0.0018 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.0123 0.0029 0.006
Loa Loa (eye worm) TK/KIN16 protein kinase 0.2147 0.5949 0.7668
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0156 0.0124 0.0173
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0541 0.1251 0.1608
Echinococcus multilocularis c src tyrosine kinase 0.026 0.0429 0.0612
Schistosoma mansoni serine/threonine protein kinase 0.0321 0.0608 0.1248
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.1161 0.3064 0.3062
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0635 0.1526 0.1964
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0179 0.0192 0.0271
Schistosoma mansoni serine/threonine protein kinase 0.0419 0.0894 0.1835
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0266 0.0446 0.474
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0217 0.0302 0.0385
Trichomonas vaginalis CMGC family protein kinase 0.035 0.0694 0.3373
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0133 0.0059 0.012
Onchocerca volvulus 0.0182 0.0202 0.0387
Loa Loa (eye worm) hypothetical protein 0.0285 0.0503 0.0644
Trichomonas vaginalis AGC family protein kinase 0.021 0.0284 0.1327
Trichomonas vaginalis STE family protein kinase 0.0159 0.0135 0.0584
Loa Loa (eye worm) hypothetical protein 0.0133 0.0059 0.0071
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0217 0.0304 0.1527
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0149 0.0104 0.0144
Trypanosoma brucei SNF1-related protein kinases, putative 0.0167 0.0158 0.0737
Trypanosoma cruzi cdc2-related kinase 1 0.0321 0.0608 0.3127
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0217 0.0302 0.1529
Trichomonas vaginalis CMGC family protein kinase 0.0123 0.0029 0.0056
Brugia malayi Protein kinase domain containing protein 0.0419 0.0894 0.1148
Echinococcus granulosus cyclin dependent kinase 5 0.0321 0.0608 0.0605
Trypanosoma cruzi casein kinase II, putative 0.0266 0.0446 0.2279
Trichomonas vaginalis CAMK family protein kinase 0.0167 0.0158 0.0698
Loa Loa (eye worm) TK/FAK protein kinase 0.0615 0.1467 0.1888
Onchocerca volvulus 0.0304 0.0557 0.1079
Brugia malayi Furin-like cysteine rich region family protein 0.1779 0.4872 0.6279
Echinococcus multilocularis growth factor receptor bound protein 2 0.0159 0.0132 0.0185
Loa Loa (eye worm) hypothetical protein 0.019 0.0225 0.0285
Trypanosoma cruzi casein kinase, putative 0.0217 0.0302 0.1529
Trichomonas vaginalis AGC family protein kinase 0.04 0.084 0.4102
Echinococcus multilocularis mitogen activated protein kinase 11 0.0441 0.0958 0.1376
Toxoplasma gondii AGC kinase 0.0225 0.0328 0.165
Echinococcus granulosus serine threonine protein kinase nrc 0.0433 0.0937 0.0933
Echinococcus granulosus protein kinase c epsilon type 0.0532 0.1224 0.1221
Trypanosoma cruzi casein kinase, putative 0.0217 0.0302 0.1529
Echinococcus granulosus ephrin type A receptor 4 A 0.0291 0.0521 0.0517
Brugia malayi Protein kinase domain containing protein 0.0187 0.0215 0.0273
Plasmodium falciparum casein kinase 2, alpha subunit 0.0266 0.0446 0.474
Brugia malayi Peroxidasin 0.0115 0.0006 0.0002
Echinococcus granulosus Glutaredoxin protein 5 0.0367 0.0743 0.0739
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0541 0.1251 0.2431
Schistosoma mansoni vam6/vps39 related 0.0133 0.0059 0.012
Entamoeba histolytica hypothetical protein 0.0331 0.0638 0.3123
Echinococcus multilocularis rac serine:threonine kinase 0.0452 0.0991 0.1422
Trichomonas vaginalis CK1 family protein kinase 0.0217 0.0302 0.1419
Plasmodium vivax serine/threonine protein kinase, putative 0.0117 0.001 0.0066
Schistosoma mansoni septate junction protein 0.0115 0.0004 0.0008
Giardia lamblia Kinase, STE STE20 0.022 0.0312 0.1577
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0167 0.0158 0.1655
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0433 0.0937 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0127 0.0039 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0419 0.0894 0.1835
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0131 0.0051 0.0216
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0321 0.0608 0.3078
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0225 0.0328 0.1581
Trypanosoma brucei aurora B kinase 0.04 0.084 0.4126
Schistosoma mansoni protein kinase 0.0159 0.0135 0.0277
Entamoeba histolytica protein kinase, putative 0.0183 0.0203 0.096
Onchocerca volvulus 0.0217 0.0302 0.0583
Echinococcus granulosus serine:threonine protein kinase MARK2 0.053 0.1218 0.1215
Plasmodium falciparum calcium-dependent protein kinase 5 0.0179 0.0192 0.2018
Echinococcus multilocularis raf serine:threonine protein kinase 0.0211 0.0284 0.0405
Trichomonas vaginalis CMGC family protein kinase 0.0123 0.0029 0.0056
Echinococcus granulosus myotubularin protein 13 0.0128 0.0042 0.0038
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0198 0.0247 0.0351
Echinococcus multilocularis rho associated protein kinase 0.0934 0.24 0.3453
Trichomonas vaginalis CMGC family protein kinase 0.0266 0.0446 0.2135
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0217 0.0304 0.1461
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0167 0.0158 0.0737
Schistosoma mansoni tyrosine kinase 0.1296 0.346 0.7102
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0225 0.0328 0.1581
Entamoeba histolytica protein kinase, putative 0.035 0.0694 0.34
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0321 0.0608 0.078
Loa Loa (eye worm) hypothetical protein 0.0635 0.1526 0.1964
Echinococcus multilocularis twitchin 0.0121 0.0022 0.0026
Trichomonas vaginalis CMGC family protein kinase 0.0217 0.0304 0.1425
Loa Loa (eye worm) CAMK protein kinase 0.0133 0.0057 0.0068
Echinococcus granulosus dual specificity protein kinase clk2 0.0187 0.0217 0.0213
Brugia malayi phosphoinositide-dependent protein kinase I 0.021 0.0284 0.0362
Trichomonas vaginalis AGC family protein kinase 0.04 0.084 0.4102
Trichomonas vaginalis CAMK family protein kinase 0.0344 0.0674 0.3273
Giardia lamblia Kinase, AGC AKT 0.0316 0.0593 0.3048
Brugia malayi Protein kinase domain containing protein 0.2765 0.7757 1
Echinococcus granulosus mitogen activated protein kinase 11 0.0441 0.0958 0.0955
Loa Loa (eye worm) AUR protein kinase 0.04 0.084 0.1079
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0433 0.0937 0.4843
Onchocerca volvulus Serine\/threonine kinase homolog 0.0198 0.0247 0.0475
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0236 0.036 0.046
Entamoeba histolytica protein kinase, putative 0.0419 0.0894 0.4394
Entamoeba histolytica protein kinase, putative 0.0159 0.0135 0.0623
Echinococcus multilocularis Glutaredoxin protein 5 0.0367 0.0743 0.1065
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0167 0.0158 0.0775
Schistosoma mansoni serine/threonine protein kinase 0.0167 0.0158 0.0324
Onchocerca volvulus 0.0123 0.0029 0.005
Trichomonas vaginalis AGC family protein kinase 0.0439 0.0954 0.467
Brugia malayi Protein kinase domain containing protein 0.0307 0.0568 0.0727
Giardia lamblia Kinase, CAMK CAMKL 0.0167 0.0158 0.0775
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0254 0.0411 0.0408
Loa Loa (eye worm) AUR protein kinase 0.04 0.084 0.1079
Brugia malayi Protein kinase domain 0.0224 0.0323 0.0412
Schistosoma mansoni hypothetical protein 0.0222 0.0319 0.0655
Brugia malayi Protein kinase domain containing protein 0.0117 0.001 0.0008
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0131 0.0051 0.0061
Schistosoma mansoni serine/threonine protein kinase 0.0225 0.0328 0.0673
Echinococcus granulosus Protein kinase C brain isozyme 0.065 0.1569 0.1566
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0167 0.0158 0.0775
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0479 0.1071 0.1376
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0479 0.1071 0.1376
Schistosoma mansoni tyrosine kinase 0.1161 0.3064 0.6289

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.