TDR Targets

Basic information

Technical information

TDR Targets ID: 1414676
Name: 2-hydroxy-5,5-dimethyl-1,2,6,10b-tetrahydropy rrolo[5,1-a]isoquinolin-3-one
MW: 231.29 | Formula: C14H17NO2
H donors: 1 H acceptors: 2 LogP: 1.42 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: O=C1C(O)CC2N1C(C)(C)Cc1c2cccc1
InChi: 1S/C14H17NO2/c1-14(2)8-9-5-3-4-6-10(9)11-7-12(16)13(17)15(11)14/h3-6,11-12,16H,7-8H2,1-2H3
InChiKey: JARCDROXSKEJGZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

STOCK1N-26797
Oprea1_390582
2-Hydroxy-5,5-dimethyl-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolin-3-one
2-Hydroxy-5,5-dimethyl-1,5,6,10b-tetrahydropyrrolo[2,1-a]isoquinolin-3(2H)-one
Oprea1_366876
MLS000089972
SMR000024590

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D	Starlite/ChEMBL	No references
Homo sapiens	arachidonate 15-lipoxygenase	Starlite/ChEMBL	No references
Homo sapiens	thyroid stimulating hormone receptor	Starlite/ChEMBL	No references
Homo sapiens	ubiquitin specific peptidase 1	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Loa Loa (eye worm)	follicle stimulating hormone receptor	Get druggable targets OG5_130089	All targets in OG5_130089
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	follicle stimulating hormone receptor	Get druggable targets OG5_130089	All targets in OG5_130089
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	arachidonate 5 lipoxygenase	arachidonate 15-lipoxygenase	662 aa	590 aa	23.9 %
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Echinococcus granulosus	protein tyrosine kinase	0.0055	0.004	0.0031
Echinococcus multilocularis	tyrosine protein kinase shark	0.0055	0.004	0.0031
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0055	0.004	0.0031
Echinococcus granulosus	plexin a4	0.1034	0.2031	0.2415
Schistosoma mansoni	protein kinase	0.0055	0.004	0.0018
Echinococcus granulosus	cytohesin 1	0.0074	0.0079	0.0078
Entamoeba histolytica	hypothetical protein	0.0094	0.0119	0.0519
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0074	0.0079	0.0078
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.0079	0.0254
Echinococcus multilocularis	epidermal growth factor receptor	0.0055	0.004	0.0031
Toxoplasma gondii	aurora kinase	0.0081	0.0093	0.6732
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0081	0.0093	0.0349
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0803	0.1562	0.1543
Echinococcus granulosus	tyrosine protein kinase pr2	0.0055	0.004	0.0031
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0803	0.1562	0.156
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0055	0.004	0.0031
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0222	0.0219
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0055	0.004	0.0031
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0074	0.0079	0.0254
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0074	0.0079	0.0076
Schistosoma mansoni	syntrophin	0.0074	0.0079	0.0057
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Echinococcus granulosus	tyrosine protein kinase csk	0.0055	0.004	0.0031
Schistosoma mansoni	axis inhibition protein axin	0.0803	0.1562	0.1543
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Schistosoma mansoni	protein kinase	0.0055	0.004	0.0018
Trypanosoma cruzi	hypothetical protein	0.0074	0.0079	0.4895
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0094	0.0119	1
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0803	0.1562	1
Echinococcus granulosus	oxysterol binding protein 1	0.0074	0.0079	0.0078
Echinococcus granulosus	activated cdc42 kinase 1	0.0055	0.004	0.0031
Onchocerca volvulus		0.0055	0.004	0.0236
Trypanosoma cruzi	hypothetical protein	0.0074	0.0079	0.4895
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0055	0.004	0.0031
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Echinococcus granulosus	natriuretic peptide receptor 1	0.0055	0.004	0.0031
Brugia malayi	DNA-binding protein LAG-1	0.0162	0.0259	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0055	0.004	0.0037
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0055	0.004	0.0026
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Schistosoma mansoni	hypothetical protein	0.0074	0.0079	0.0057
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0074	0.0079	0.0078
Entamoeba histolytica	hypothetical protein	0.0094	0.0119	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0135	0.0132
Trichomonas vaginalis	centaurin alpha, putative	0.0074	0.0079	0.0453
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0074	0.0079	0.0065
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0074	0.0079	0.0078
Loa Loa (eye worm)	sema domain-containing protein	0.037	0.0681	0.0679
Entamoeba histolytica	hypothetical protein	0.0162	0.0259	0.1435
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.4151	0.8367	1
Echinococcus granulosus	serine/threonine protein kinase	0.0094	0.0119	0.0126
Loa Loa (eye worm)	TK/FAK protein kinase	0.0055	0.004	0.0037
Onchocerca volvulus		0.0074	0.0079	0.0463
Plasmodium falciparum	oxysterol-binding protein, putative	0.0074	0.0079	0.4895
Loa Loa (eye worm)	TK/FER protein kinase	0.0055	0.004	0.0037
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.4151	0.8367	0.8365
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Loa Loa (eye worm)	TK protein kinase	0.0055	0.004	0.0037
Brugia malayi	hypothetical protein	0.0055	0.004	0.0026
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0055	0.004	0.0031
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0074	0.0079	0.0453
Loa Loa (eye worm)	TK protein kinase	0.0055	0.004	0.0037
Brugia malayi	PH domain containing protein	0.0074	0.0079	0.0065
Schistosoma mansoni	regulator of G protein signaling	0.0803	0.1562	0.1543
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0074	0.0079	0.0078
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Loa Loa (eye worm)	TK/FER protein kinase	0.0055	0.004	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0079	0.0453
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0055	0.004	0.0031
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0803	0.1562	1
Onchocerca volvulus		0.0182	0.03	0.1763
Brugia malayi	Syntrophin-1	0.0074	0.0079	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0079	0.0076
Brugia malayi	hypothetical protein	0.037	0.0681	0.0668
Schistosoma mansoni	protein kinase	0.0075	0.0081	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0079	0.0076
Echinococcus granulosus	regulator of G protein signaling 3	0.0803	0.1562	0.1853
Trichomonas vaginalis	hypothetical protein	0.0074	0.0079	0.0453
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0074	0.0079	0.0078
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0055	0.004	0.0031
Onchocerca volvulus		0.0055	0.004	0.0236
Echinococcus multilocularis	Immunoglobulin	0.0096	0.0124	0.0132
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.1623	0.1926
Schistosoma mansoni	hypothetical protein	0.0074	0.0079	0.0057
Schistosoma mansoni	regulator of G protein signaling	0.0803	0.1562	0.1543
Entamoeba histolytica	protein kinase , putative	0.0081	0.0093	0.0349
Schistosoma mansoni	plexin	0.0872	0.1702	0.1683
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0042	0.0014	0.0011
Brugia malayi	follicle stimulating hormone receptor	0.028	0.0498	0.0484
Brugia malayi	Variant SH3 domain containing protein	0.0074	0.0079	0.0065
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0074	0.0079	0.0453
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0055	0.004	0.0031
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Loa Loa (eye worm)	TK protein kinase	0.0055	0.004	0.0037
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Brugia malayi	SH2 domain containing protein	0.0055	0.004	0.0026
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0074	0.0079	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0079	0.0076
Schistosoma mansoni	protein kinase	0.0075	0.0081	0.0059
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0055	0.004	0.0037
Entamoeba histolytica	protein kinase, putative	0.0094	0.0119	0.0519
Trichomonas vaginalis	centaurin/arf, putative	0.0074	0.0079	0.0453
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0055	0.004	0.0031
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0055	0.004	0.0026
Brugia malayi	PH domain containing protein	0.0074	0.0079	0.0065
Loa Loa (eye worm)	TK/INSR protein kinase	0.0055	0.004	0.0037
Loa Loa (eye worm)	uncoordinated protein 104	0.0074	0.0079	0.0076
Echinococcus multilocularis	regulator of G protein signaling 7	0.0803	0.1562	0.1853
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0074	0.0079	0.0453
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.4151	0.8367	0.8367
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0094	0.0119	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0055	0.004	0.0037
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0074	0.0079	0.0463
Trypanosoma brucei	PH domain containing protein, putative	0.0074	0.0079	0.4895
Echinococcus granulosus	receptor type guanylyl cyclase	0.0055	0.004	0.0031
Loa Loa (eye worm)	TK/EPH protein kinase	0.0055	0.004	0.0037
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0055	0.004	0.0037
Schistosoma mansoni	protein kinase	0.0055	0.004	0.0018
Schistosoma mansoni	oxysterol-binding protein 1	0.0074	0.0079	0.0057
Echinococcus multilocularis	Pleckstrin y	0.0074	0.0079	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.004	0.0204
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0074	0.0079	0.0078
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0055	0.004	0.0031
Brugia malayi	integrin-linked kinase	0.0055	0.004	0.0026
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0055	0.004	0.0031
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0162	0.0259	0.161
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.2994	0.6016	0.7185
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0055	0.004	0.0204
Schistosoma mansoni	oxysterol-binding protein 1	0.0074	0.0079	0.0057
Echinococcus granulosus	neuroglian	0.0096	0.0124	0.0132
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.0079	0.0254
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Echinococcus multilocularis	regulator of G protein signaling 3	0.0803	0.1562	0.1853
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Trichomonas vaginalis	conserved hypothetical protein	0.0803	0.1562	1
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0162	0.0259	0.161
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0135	0.0132
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.0079	0.0254
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0074	0.0079	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0079	0.0076
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.004	0.0204
Trypanosoma cruzi	PH domain containing protein, putative	0.0074	0.0079	0.4895
Loa Loa (eye worm)	TK/FER protein kinase	0.0055	0.004	0.0037
Brugia malayi	Oxysterol-binding protein	0.0074	0.0079	0.0065
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Loa Loa (eye worm)	oxysterol binding protein	0.0074	0.0079	0.0076
Echinococcus granulosus	oxysterol binding protein 9	0.0074	0.0079	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0124	0.0122
Schistosoma mansoni	serine/threonine protein kinase	0.3797	0.7649	0.7643
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0074	0.0079	0.0254
Brugia malayi	serine/threonine protein kinase 6	0.0081	0.0093	0.0079
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0055	0.004	0.0204
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0074	0.0079	0.4895
Loa Loa (eye worm)	RGS-3 protein	0.0803	0.1562	0.156
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Echinococcus multilocularis	axis inhibition protein axin	0.0803	0.1562	0.1853
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0075	0.0081	0.5105
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Echinococcus granulosus	axis inhibition protein axin	0.0803	0.1562	0.1853
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.1623	0.1605
Echinococcus granulosus	tyrosine kinase	0.0055	0.004	0.0031
Brugia malayi	regulator of G-protein signaling egl-10	0.0803	0.1562	0.155
Schistosoma mansoni	z-protein (S1r protein)	0.0803	0.1562	0.1543
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0055	0.004	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0259	0.0256
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0094	0.0119	0.0712
Trichomonas vaginalis	alpha chimerin, putative	0.0074	0.0079	0.0453
Entamoeba histolytica	PH domain containing protein	0.0074	0.0079	0.0254
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0259	0.0256
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.004	0.0018
Trypanosoma cruzi	Protein kinase B	0.0094	0.0119	1
Schistosoma mansoni	protein kinase	0.0075	0.0081	0.0059
Echinococcus multilocularis	FL cytokine receptor	0.0055	0.004	0.0031
Schistosoma mansoni	plexin	0.0502	0.0949	0.0929
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0151	0.0236	0.0222
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0096	0.0124	0.0132
Trichomonas vaginalis	protein transport protein sec7, putative	0.0074	0.0079	0.0453
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.006	0.0051	0.0044
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0055	0.004	0.0026
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Brugia malayi	hypothetical protein	0.0101	0.0135	0.0121
Echinococcus multilocularis	activin receptor type	0.0075	0.0081	0.008
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0055	0.004	0.0031
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.0079	0.0254
Brugia malayi	hypothetical protein	0.0182	0.03	0.0286
Entamoeba histolytica	hypothetical protein	0.0074	0.0079	0.0254
Echinococcus granulosus	integrin linked protein kinase	0.0055	0.004	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.0162	0.0259	0.161
Echinococcus granulosus	tyrosine protein kinase shark	0.0055	0.004	0.0031
Schistosoma mansoni	protein kinase	0.0055	0.004	0.0018
Echinococcus multilocularis	activated cdc42 kinase 1	0.0055	0.004	0.0031
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0055	0.004	0.0031
Leishmania major	hypothetical protein, conserved	0.0074	0.0079	0.4895
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0803	0.1562	0.1543
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0096	0.0124	0.0103
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Onchocerca volvulus		0.0055	0.004	0.0236
Echinococcus granulosus	semaphorin 5B	0.037	0.0681	0.0799
Echinococcus multilocularis	tyrosine protein kinase csk	0.0055	0.004	0.0031
Loa Loa (eye worm)	AUR protein kinase	0.0081	0.0093	0.0091
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0055	0.004	0.0026
Trypanosoma cruzi	PH domain containing protein, putative	0.0074	0.0079	0.4895
Schistosoma mansoni	goodpasture antigen-binding protein	0.0074	0.0079	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0124	0.0122
Brugia malayi	protein-tyrosine kinase	0.0055	0.004	0.0026
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0094	0.0119	1
Entamoeba histolytica	tyrosin kinase, putative	0.0217	0.037	0.2166
Toxoplasma gondii	hypothetical protein	0.0074	0.0079	0.4895
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0124	0.0122
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Echinococcus granulosus	tyrosine protein kinase csk	0.0055	0.004	0.0031
Echinococcus multilocularis	expressed protein	0.0803	0.1562	0.1853
Schistosoma mansoni	axis inhibition protein axin	0.0803	0.1562	0.1543
Schistosoma mansoni	regulator of G protein signaling	0.0803	0.1562	0.1543
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0094	0.0119	1
Echinococcus granulosus	tyrosine protein kinase	0.0055	0.004	0.0031
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0094	0.0119	0.0519
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0075	0.0081	0.008
Brugia malayi	MH2 domain containing protein	0.0144	0.0222	0.0208
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0055	0.004	0.0031
Brugia malayi	Sema domain containing protein	0.037	0.0681	0.0668
Echinococcus multilocularis	plexin a4	0.1034	0.2031	0.2415
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Echinococcus granulosus	beta-adrenergic receptor kinase	0.3797	0.7649	0.914
Loa Loa (eye worm)	hypothetical protein	0.0502	0.0949	0.0947
Echinococcus granulosus	dynamin 1	0.0074	0.0079	0.0078
Loa Loa (eye worm)	TK/FER protein kinase	0.0055	0.004	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0124	0.0122
Echinococcus granulosus	Regulator of G protein signaling 20	0.0803	0.1562	0.1853
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0055	0.004	0.0037
Loa Loa (eye worm)	TK/CSK protein kinase	0.0055	0.004	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0803	0.1562	0.156
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0075	0.0081	0.008
Entamoeba histolytica	protein kinase, putative	0.0094	0.0119	0.0519
Toxoplasma gondii	protein kinase domain-containing protein	0.0094	0.0119	1
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Onchocerca volvulus		0.0074	0.0079	0.0463
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0081	0.0093	0.0349
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0055	0.004	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.0162	0.0259	0.161
Loa Loa (eye worm)	TK/FER protein kinase	0.0055	0.004	0.0037
Loa Loa (eye worm)	SRC-1	0.0055	0.004	0.0037
Entamoeba histolytica	hypothetical protein, conserved	0.0074	0.0079	0.0254
Loa Loa (eye worm)	TK/ALK protein kinase	0.0304	0.0546	0.0544
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0803	0.1562	0.156
Echinococcus multilocularis	exocyst complex component 2	0.0162	0.0259	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0079	0.0076
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0803	0.1562	0.1543
Onchocerca volvulus		0.0074	0.0079	0.0463
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0094	0.0119	0.0712
Onchocerca volvulus		0.0055	0.004	0.0236
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0074	0.0079	0.0076
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Brugia malayi	PH domain containing protein	0.0074	0.0079	0.0065
Onchocerca volvulus		0.0055	0.004	0.0236
Schistosoma mansoni	serine/threonine protein kinase	0.4954	1	1
Schistosoma mansoni	ephrin receptor	0.006	0.0051	0.0029
Echinococcus multilocularis	protein tyrosine kinase	0.0055	0.004	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0079	0.0453
Entamoeba histolytica	hypothetical protein	0.0803	0.1562	1
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0055	0.004	0.0037
Onchocerca volvulus		0.0074	0.0079	0.0463
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.1623	0.1926
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Entamoeba histolytica	protein kinase domain containing protein	0.0217	0.037	0.2166
Entamoeba histolytica	protein kinase, putative	0.0081	0.0093	0.0349
Brugia malayi	Guanylyl cyclase protein 23	0.0055	0.004	0.0026
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0094	0.0119	1
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Schistosoma mansoni	protein kinase	0.0055	0.004	0.0018
Brugia malayi	Cytohesin 3	0.0074	0.0079	0.0065
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0074	0.0079	0.0065
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0162	0.0259	0.161
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0079	0.0453
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Entamoeba histolytica	protein kinase, putative	0.0094	0.0119	0.0519
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0055	0.004	0.0037
Entamoeba histolytica	protein kinase, putative	0.0094	0.0119	0.0519
Echinococcus granulosus	Pleckstrin y	0.0074	0.0079	0.0078
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Brugia malayi	hypothetical protein	0.0055	0.004	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0162	0.0259	0.161
Loa Loa (eye worm)	serine/threonine protein kinase	0.0055	0.004	0.0037
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0074	0.0079	0.0057
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0081	0.0093	0.6732
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Trypanosoma cruzi	NIMA-related kinase, putative	0.0094	0.0119	1
Trichomonas vaginalis	TK family protein kinase	0.0055	0.004	0.0204
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0081	0.0093	0.6732
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0074	0.0079	0.4895
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0055	0.004	0.0031
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.3797	0.7649	0.7648
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0074	0.0079	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0803	0.1562	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0055	0.004	0.0031
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0074	0.0079	0.0254
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0055	0.004	0.0031
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Toxoplasma gondii	Oxysterol-binding protein	0.0074	0.0079	0.4895
Loa Loa (eye worm)	TK/FER protein kinase	0.0055	0.004	0.0037
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0074	0.0079	0.0254
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0055	0.004	0.0204
Onchocerca volvulus		0.0055	0.004	0.0236
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.006	0.0051	0.0044
Echinococcus granulosus	GRB2 associated binding protein 3	0.0074	0.0079	0.0078
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0055	0.004	0.0037
Brugia malayi	Tyrosine-protein kinase abl-1	0.0055	0.004	0.0026
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Brugia malayi	hypothetical protein	0.0055	0.004	0.0026
Brugia malayi	PH domain containing protein	0.0074	0.0079	0.0065
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0074	0.0079	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0055	0.004	0.0031
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0081	0.0093	0.0095
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0055	0.004	0.0037
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Brugia malayi	Cadps2 protein	0.0074	0.0079	0.0065
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Loa Loa (eye worm)	TK/RYK protein kinase	0.0055	0.004	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0079	0.0076
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Schistosoma mansoni	tyrosine protein kinase	0.0055	0.004	0.0018
Trichomonas vaginalis	centaurin/arf, putative	0.0074	0.0079	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0055	0.004	0.0037
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0074	0.0079	0.0065
Trypanosoma cruzi	aurora B kinase, putative	0.0081	0.0093	0.6732
Echinococcus granulosus	aurora kinase A	0.0081	0.0093	0.0095
Loa Loa (eye worm)	cytohesin 3	0.0074	0.0079	0.0076
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0055	0.004	0.0018
Loa Loa (eye worm)	hypothetical protein	0.037	0.0681	0.0679
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Brugia malayi	Sema domain containing protein	0.037	0.0681	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0375	0.0372
Echinococcus granulosus	transcription factor collier	0.0162	0.0259	0.0293
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Echinococcus multilocularis	tyrosine protein kinase csk	0.0055	0.004	0.0031
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0074	0.0079	0.0057
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0074	0.0079	0.0076
Brugia malayi	hypothetical protein	0.0803	0.1562	0.155
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0079	0.0453
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.0079	0.0254
Onchocerca volvulus		0.0055	0.004	0.0236
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0803	0.1562	0.155
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Loa Loa (eye worm)	Plekhf2 protein	0.0074	0.0079	0.0076
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0055	0.004	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.004	0.0204
Echinococcus granulosus	tyrosine protein kinase Blk	0.0055	0.004	0.0031
Trypanosoma cruzi	hypothetical protein	0.0074	0.0079	0.4895
Echinococcus granulosus	protein kinase	0.0055	0.004	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0055	0.004	0.0037
Onchocerca volvulus		0.0055	0.004	0.0236
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0055	0.004	0.0204
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.004	0.0018
Plasmodium vivax	hypothetical protein, conserved	0.0074	0.0079	0.4895
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0055	0.004	0.0204
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0803	0.1562	0.1853
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0079	0.0076
Brugia malayi	Protein kinase domain containing protein	0.0094	0.0119	0.0105
Trichomonas vaginalis	AGC family protein kinase	0.0081	0.0093	0.0546
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Echinococcus multilocularis	regulator of G protein signaling	0.0803	0.1562	0.1853
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0055	0.004	0.0031
Schistosoma mansoni	growth factor receptor-bound protein	0.0074	0.0079	0.0057
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0074	0.0079	0.4895
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0074	0.0079	0.0453
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0055	0.004	0.0031
Entamoeba histolytica	hypothetical protein	0.0803	0.1562	1
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.4954	1	1
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.004	0.0018
Brugia malayi	Oxysterol binding protein	0.0074	0.0079	0.0065
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0055	0.004	0.0037
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0055	0.004	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0079	0.0076
Entamoeba histolytica	hypothetical protein	0.0074	0.0079	0.0254
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0075	0.0081	0.5105
Loa Loa (eye worm)	hypothetical protein	0.0055	0.004	0.0037
Echinococcus granulosus	Immunoglobulin	0.0096	0.0124	0.0132
Entamoeba histolytica	protein kinase, putative	0.0094	0.0119	0.0519
Trichomonas vaginalis	protein transport protein sec7, putative	0.0074	0.0079	0.0453
Echinococcus granulosus	G protein coupled receptor kinase 1	0.2994	0.6016	0.7185
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0094	0.0119	0.0519
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.028	0.0498	0.0495
Brugia malayi	plexin A	0.1034	0.2031	0.202
Trypanosoma brucei	aurora B kinase	0.0081	0.0093	0.6732
Schistosoma mansoni	zinc finger protein	0.0074	0.0079	0.0057
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0074	0.0079	0.0078
Leishmania major	hypothetical protein, conserved	0.0074	0.0079	0.4895
Loa Loa (eye worm)	plexin A	0.1034	0.2031	0.2029
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Brugia malayi	SRC-1	0.0055	0.004	0.0026
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0094	0.0119	1
Trichomonas vaginalis	conserved hypothetical protein	0.0803	0.1562	1
Trichomonas vaginalis	conserved hypothetical protein	0.0162	0.0259	0.161
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Loa Loa (eye worm)	TK protein kinase	0.0055	0.004	0.0037
Trichomonas vaginalis	STE family protein kinase	0.0055	0.004	0.0204
Loa Loa (eye worm)	hypothetical protein	0.037	0.0681	0.0679
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0074	0.0079	0.0078
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0055	0.004	0.0031
Entamoeba histolytica	protein kinase domain containing protein	0.0081	0.0093	0.0349
Brugia malayi	Furin-like cysteine rich region family protein	0.0055	0.004	0.0026
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.0079	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0079	0.0076
Loa Loa (eye worm)	TK protein kinase	0.0055	0.004	0.0037
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0803	0.1562	0.1853
Echinococcus multilocularis	heat shock protein 70	0.0055	0.004	0.0031
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0055	0.004	0.0031
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0135	0.0132
Schistosoma mansoni	hypothetical protein	0.0074	0.0079	0.0057
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0055	0.004	0.0018
Leishmania major	serine/threonine-protein kinase a, putative	0.0094	0.0119	1
Loa Loa (eye worm)	hypothetical protein	0.0803	0.1562	0.156
Schistosoma mansoni	protein kinase	0.0055	0.004	0.0018
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0055	0.004	0.0031
Entamoeba histolytica	protein kinase, putative	0.0081	0.0093	0.0349
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0094	0.0119	1
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0162	0.0259	0.161
Echinococcus granulosus	pleckstrin y domain containing family A	0.0074	0.0079	0.0078
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0055	0.004	0.0031
Onchocerca volvulus	outspread protein homolog	0.0074	0.0079	0.0463
Brugia malayi	hypothetical protein	0.0803	0.1562	0.155
Loa Loa (eye worm)	TK protein kinase	0.0055	0.004	0.0037
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Brugia malayi	serine/threonine kinase 12	0.0081	0.0093	0.0079
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0222	0.0219
Echinococcus granulosus	regulator of G protein signaling 3	0.0803	0.1562	0.1853
Brugia malayi	regulator of G-protein signaling rgs-7	0.0803	0.1562	0.155
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0074	0.0079	0.0254
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0074	0.0079	0.0078
Schistosoma mansoni	hypothetical protein	0.0162	0.0259	0.0237
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0074	0.0079	0.4895
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Echinococcus multilocularis	tyrosine protein kinase	0.0055	0.004	0.0031
Loa Loa (eye worm)	TK/FER protein kinase	0.0055	0.004	0.0037
Echinococcus multilocularis	actin binding protein anillin	0.0074	0.0079	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0079	0.0453
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0094	0.0119	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0055	0.004	0.0026
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0094	0.0119	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0079	0.0076
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0055	0.004	0.0031
Schistosoma mansoni	regulator of G protein signaling	0.0803	0.1562	0.1543
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0055	0.004	0.0031
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Giardia lamblia	Aurora kinase	0.0081	0.0093	1
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Entamoeba histolytica	hypothetical protein	0.0074	0.0079	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0055	0.004	0.0037
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0162	0.0259	0.161
Echinococcus granulosus	ephrin type A receptor 4 A	0.0055	0.004	0.0031
Trichomonas vaginalis	centaurin gamma, putative	0.0074	0.0079	0.0453
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0055	0.004	0.0031
Onchocerca volvulus		0.0055	0.004	0.0236
Echinococcus multilocularis	beta adrenergic receptor kinase	0.3797	0.7649	0.914
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0079	0.0453
Brugia malayi	Variant SH3 domain containing protein	0.0074	0.0079	0.0065
Schistosoma mansoni	hypothetical protein	0.0162	0.0259	0.0237
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0055	0.004	0.0026
Brugia malayi	TBC domain containing protein	0.0074	0.0079	0.0065
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0074	0.0079	0.0078
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0074	0.0079	0.4895
Toxoplasma gondii	hypothetical protein	0.0074	0.0079	0.4895
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Onchocerca volvulus		0.0055	0.004	0.0236
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0079	0.0453
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Entamoeba histolytica	hypothetical protein	0.0074	0.0079	0.0254
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0055	0.004	0.0031
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0075	0.0081	0.5105
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Onchocerca volvulus		0.0055	0.004	0.0236
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0055	0.004	0.0031
Echinococcus granulosus	twitchin	0.0116	0.0165	0.018
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0055	0.004	0.0018
Trichomonas vaginalis	AGC family protein kinase	0.0081	0.0093	0.0546
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Schistosoma mansoni	rho gtpase activating protein	0.0074	0.0079	0.0057
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0055	0.004	0.0037
Brugia malayi	Plexin repeat family protein	0.0872	0.1702	0.169
Loa Loa (eye worm)	TK/FER protein kinase	0.0055	0.004	0.0037
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0094	0.0119	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0055	0.004	0.0031
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0074	0.0079	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Echinococcus multilocularis	transcription factor collier	0.0162	0.0259	0.0293
Trichomonas vaginalis	AGC family protein kinase	0.0055	0.004	0.0204
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Loa Loa (eye worm)	TK/FER protein kinase	0.0055	0.004	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.004	0.0204
Schistosoma mansoni	goodpasture antigen-binding protein	0.0074	0.0079	0.0057
Onchocerca volvulus		0.0055	0.004	0.0236
Brugia malayi	Protein kinase domain containing protein	0.0304	0.0547	0.0533
Echinococcus multilocularis	protein kinase	0.0055	0.004	0.0031
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Echinococcus multilocularis	tyrosine protein kinase csk	0.0055	0.004	0.0031
Loa Loa (eye worm)	PH domain-containing protein	0.0074	0.0079	0.0076
Brugia malayi	Dynamin	0.0074	0.0079	0.0065
Schistosoma mansoni	cell adhesion molecule	0.0101	0.0135	0.0113
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0055	0.004	0.0031
Echinococcus multilocularis	neuroglian	0.0096	0.0124	0.0132
Leishmania major	protein kinase, putative	0.0094	0.0119	1
Trichomonas vaginalis	centaurin beta, putative	0.0074	0.0079	0.0453
Echinococcus multilocularis	transfer RNA-Thr	0.0055	0.004	0.0031
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0075	0.0081	0.008
Schistosoma mansoni	lipoxygenase	0.0067	0.0065	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0803	0.1562	0.156
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0079	0.0453
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.004	0.0018
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0055	0.004	0.0031
Echinococcus granulosus	activated cdc42 kinase 1	0.0055	0.004	0.0031
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0074	0.0079	0.0078
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0055	0.004	0.0031
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0101	0.0135	0.0121
Schistosoma mansoni	nephrin	0.0101	0.0135	0.0113
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.004	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0803	0.1562	0.156
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0079	0.0076
Brugia malayi	PH domain containing protein	0.0074	0.0079	0.0065
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0055	0.004	0.0037
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0055	0.004	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0079	0.0453
Schistosoma mansoni	protein kinase	0.0081	0.0093	0.0072
Brugia malayi	IPT/TIG domain containing protein	0.0162	0.0259	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0124	0.0122
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0074	0.0079	0.0254
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0055	0.004	0.0037
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0094	0.0119	1
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0079	0.0453
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Trypanosoma cruzi	hypothetical protein	0.0074	0.0079	0.4895
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.004	0.0204
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0055	0.004	0.0031
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Onchocerca volvulus		0.0055	0.004	0.0236
Entamoeba histolytica	protein kinase domain containing protein	0.0075	0.0081	0.0265
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0079	0.0076
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0074	0.0079	0.4895
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0079	0.0453
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0055	0.004	0.0031
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0055	0.004	0.0031
Brugia malayi	Uncoordinated protein 104	0.0074	0.0079	0.0065
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0055	0.004	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0079	0.0076
Brugia malayi	Receptor family ligand binding region containing protein	0.0055	0.004	0.0026
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0055	0.004	0.0031
Loa Loa (eye worm)	hypothetical protein	0.037	0.0681	0.0679
Echinococcus granulosus	tyrosine protein kinase csk	0.0055	0.004	0.0031
Loa Loa (eye worm)	TK/FER protein kinase	0.0055	0.004	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0079	0.0076
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0055	0.004	0.0031
Echinococcus granulosus	epidermal growth factor receptor	0.0055	0.004	0.0031
Loa Loa (eye worm)	TK/FER protein kinase	0.0055	0.004	0.0037
Echinococcus granulosus	tyrosine protein kinase Srms	0.0055	0.004	0.0031
Entamoeba histolytica	hypothetical protein	0.0162	0.0259	0.1435
Echinococcus multilocularis	myotubularin protein 13	0.0074	0.0079	0.0078
Echinococcus multilocularis	oxysterol binding protein 9	0.0074	0.0079	0.0078
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0055	0.004	0.0031
Trypanosoma cruzi	hypothetical protein	0.0074	0.0079	0.4895
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Echinococcus multilocularis	rac serine:threonine kinase	0.0094	0.0119	0.0126
Schistosoma mansoni	hypothetical protein	0.037	0.0681	0.0661
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Schistosoma mansoni	serine/threonine RGC	0.0055	0.004	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0803	0.1562	0.1853
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0055	0.004	0.0031
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0055	0.004	0.0031
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0081	0.0093	0.0095
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0067	0.0065	0.006
Brugia malayi	Fibronectin type III domain containing protein	0.0101	0.0135	0.0121
Brugia malayi	Dynamin	0.0074	0.0079	0.0065
Echinococcus granulosus	defective proboscis extension response	0.0096	0.0124	0.0132
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0055	0.004	0.0037
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0055	0.004	0.0031
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Echinococcus granulosus	myotubularin protein 13	0.0074	0.0079	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.0081	0.0093	0.0546
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0803	0.1562	0.155
Trichomonas vaginalis	conserved hypothetical protein	0.0803	0.1562	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0079	0.0076
Echinococcus granulosus	exocyst complex component 2	0.0162	0.0259	0.0293
Echinococcus multilocularis	axis inhibition protein axin	0.0803	0.1562	0.1853
Loa Loa (eye worm)	TK/FER protein kinase	0.0055	0.004	0.0037
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0055	0.004	0.0031
Loa Loa (eye worm)	TK/Met protein kinase	0.0055	0.004	0.0037
Brugia malayi	A-kinase anchor protein 10, precursor	0.0803	0.1562	0.155
Loa Loa (eye worm)	sema domain-containing protein	0.037	0.0681	0.0679
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0094	0.0119	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0259	0.0256
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0055	0.004	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.0162	0.0259	0.161
Schistosoma mansoni	hypothetical protein	0.0502	0.0949	0.0929
Echinococcus multilocularis	oxysterol binding protein 1	0.0074	0.0079	0.0078
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0075	0.0081	0.5105
Echinococcus granulosus	activin receptor type	0.0075	0.0081	0.008
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Trypanosoma cruzi	NIMA-related kinase, putative	0.0094	0.0119	1
Leishmania major	protein kinase, putative	0.0081	0.0093	0.6732
Echinococcus granulosus	tyrosine kinase	0.0055	0.004	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0079	0.0453
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0079	0.0453
Echinococcus multilocularis	Pleckstrin y	0.0074	0.0079	0.0078
Brugia malayi	Plekhf2 protein	0.0074	0.0079	0.0065
Trichomonas vaginalis	conserved hypothetical protein	0.0803	0.1562	1
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0094	0.0119	1
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Loa Loa (eye worm)	TK protein kinase	0.0055	0.004	0.0037
Schistosoma mansoni	ephrin receptor	0.0055	0.004	0.0018
Echinococcus granulosus	calcium dependent secretion activator 1	0.0074	0.0079	0.0078
Trichomonas vaginalis	CAMK family protein kinase	0.0055	0.004	0.0204
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Trypanosoma brucei	protein kinase, putative	0.0075	0.0081	0.5105
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0079	0.0076
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Onchocerca volvulus		0.0055	0.004	0.0236
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0055	0.004	0.0037
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0094	0.0119	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0079	0.0076
Leishmania major	protein kinase, putative	0.0094	0.0119	1
Echinococcus granulosus	pdz domain containing protein	0.0074	0.0079	0.0078
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.0079	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0079	0.0076
Loa Loa (eye worm)	TK/FER protein kinase	0.0055	0.004	0.0037
Echinococcus granulosus	oxysterol binding protein 3	0.0074	0.0079	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0079	0.0453
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0094	0.0119	1
Trypanosoma cruzi	hypothetical protein	0.0074	0.0079	0.4895
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Echinococcus multilocularis	cytohesin 1	0.0074	0.0079	0.0078
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Echinococcus multilocularis	roundabout 2	0.0101	0.0135	0.0144
Trypanosoma brucei	protein kinase, putative	0.0094	0.0119	1
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.004	0.0204
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0074	0.0079	0.0078
Plasmodium vivax	PH domain containing protein	0.0074	0.0079	0.4895
Echinococcus granulosus	insulin receptor	0.0055	0.004	0.0031
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0096	0.0124	0.0103
Echinococcus granulosus	Pleckstrin y	0.0074	0.0079	0.0078
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0055	0.004	0.0018
Trypanosoma cruzi	PH domain containing protein, putative	0.0074	0.0079	0.4895
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0055	0.004	0.0031
Schistosoma mansoni	myotubularin-related protein	0.0074	0.0079	0.0057
Leishmania major	folate/biopterin transporter, putative	0.0094	0.0119	1
Onchocerca volvulus		0.0074	0.0079	0.0463
Schistosoma mansoni	zinc finger protein	0.0074	0.0079	0.0057
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0094	0.0119	1
Echinococcus granulosus	beta 1 syntrophin	0.0074	0.0079	0.0078
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0162	0.0259	0.161
Echinococcus multilocularis	regulator of G protein signaling 7	0.0803	0.1562	0.1853
Trypanosoma cruzi	hypothetical protein	0.0074	0.0079	0.4895
Echinococcus granulosus	Oxysterol binding protein 11	0.0074	0.0079	0.0078
Trichomonas vaginalis	protein kinase atn1, putative	0.0055	0.004	0.0204
Onchocerca volvulus		0.0872	0.1702	1
Echinococcus multilocularis	Immunoglobulin	0.0096	0.0124	0.0132
Brugia malayi	probable spectrin beta chain	0.0074	0.0079	0.0065
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0094	0.0119	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0094	0.0119	1
Brugia malayi	PH domain containing protein	0.0074	0.0079	0.0065
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0094	0.0119	0.0519
Loa Loa (eye worm)	TK/FER protein kinase	0.0055	0.004	0.0037
Echinococcus multilocularis	protein kinase	0.0055	0.004	0.0031
Schistosoma mansoni	semaphorin 5-related	0.037	0.0681	0.0661
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0055	0.004	0.0031
Schistosoma mansoni	protein kinase	0.0055	0.004	0.0018
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Loa Loa (eye worm)	TK/ROR protein kinase	0.0055	0.004	0.0037
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Echinococcus multilocularis	pdz domain containing protein	0.0074	0.0079	0.0078
Echinococcus multilocularis	dynamin 1	0.0074	0.0079	0.0078
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0096	0.0124	0.0132
Echinococcus multilocularis	hypothetical protein	0.037	0.0681	0.0799
Onchocerca volvulus		0.0074	0.0079	0.0463
Loa Loa (eye worm)	syntrophin-1	0.0074	0.0079	0.0076
Loa Loa (eye worm)	TK protein kinase	0.0055	0.004	0.0037
Brugia malayi	PH domain containing protein	0.0074	0.0079	0.0065
Echinococcus granulosus	tyrosine protein kinase HCK	0.0055	0.004	0.0031
Onchocerca volvulus	Tyrosine kinase homolog	0.0055	0.004	0.0236
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0074	0.0079	0.0078
Loa Loa (eye worm)	TK/FER protein kinase	0.0055	0.004	0.0037
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0094	0.0119	0.0519
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0074	0.0079	0.0078
Schistosoma mansoni	dynamin	0.0074	0.0079	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0872	0.1702	0.1699
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Echinococcus multilocularis	beta 1 syntrophin	0.0074	0.0079	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0079	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0079	0.0076
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Brugia malayi	Tyrosine-protein kinase PR2	0.0055	0.004	0.0026
Entamoeba histolytica	cell surface protease gp63, putative	0.0162	0.0259	0.1435
Schistosoma mansoni	serine/threonine-protein kinase	0.0094	0.0119	0.0097
Brugia malayi	hypothetical protein	0.0074	0.0079	0.0065
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.0079	0.0254
Brugia malayi	Probable exocyst complex component Sec5	0.0162	0.0259	0.0245
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Entamoeba histolytica	hypothetical protein	0.0803	0.1562	1
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Echinococcus granulosus	roundabout 2	0.0101	0.0135	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0055	0.004	0.0037
Entamoeba histolytica	protein kinase, putative	0.0094	0.0119	0.0519
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Onchocerca volvulus		0.0055	0.004	0.0236
Brugia malayi	ephrin receptor 1 precursor	0.0055	0.004	0.0026
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0055	0.004	0.0031
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0074	0.0079	0.0076
Schistosoma mansoni	hypothetical protein	0.037	0.0681	0.0661
Echinococcus granulosus	Pleckstrin y	0.0074	0.0079	0.0078
Entamoeba histolytica	hypothetical protein	0.0162	0.0259	0.1435
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0094	0.0119	1
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0055	0.004	0.0037
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0094	0.0119	1
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0074	0.0079	0.0057
Schistosoma mansoni	fibrocystin l	0.0162	0.0259	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0055	0.004	0.0037
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0055	0.004	0.0031
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0094	0.0119	1
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0074	0.0079	0.0078
Schistosoma mansoni	centaurin alpha	0.0074	0.0079	0.0057
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Entamoeba histolytica	PH domain containing protein	0.0074	0.0079	0.0254
Brugia malayi	Protein kinase domain containing protein	0.0055	0.004	0.0026
Echinococcus granulosus	kinase suppressor of Ras 1	0.0055	0.004	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0055	0.004	0.0037
Onchocerca volvulus		0.037	0.0681	0.4004
Loa Loa (eye worm)	TK/DDR protein kinase	0.0055	0.004	0.0037
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0081	0.0093	0.0349
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0055	0.004	0.0031
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Echinococcus multilocularis	oxysterol binding protein 3	0.0074	0.0079	0.0078
Echinococcus multilocularis	tyrosine kinase	0.0055	0.004	0.0031
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0074	0.0079	0.0057
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0055	0.004	0.0031
Loa Loa (eye worm)	AUR protein kinase	0.0081	0.0093	0.0091
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Brugia malayi	C-terminal src kinase protein 1	0.0055	0.004	0.0026
Brugia malayi	PXA domain containing protein	0.0803	0.1562	0.155
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0074	0.0079	0.0078
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0055	0.004	0.0031
Loa Loa (eye worm)	hypothetical protein	0.037	0.0681	0.0679
Schistosoma mansoni	hypothetical protein	0.0074	0.0079	0.0057
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0074	0.0079	0.4895
Entamoeba histolytica	hypothetical protein	0.0162	0.0259	0.1435
Plasmodium falciparum	protein kinase, putative	0.0075	0.0081	0.5105
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Echinococcus granulosus	semaphorin 1A	0.037	0.0681	0.0799
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0074	0.0079	0.4895
Entamoeba histolytica	hypothetical protein	0.0074	0.0079	0.0254
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0067	0.0065	0.006
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0074	0.0079	0.0078
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0055	0.004	0.0031
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0074	0.0079	0.4895
Onchocerca volvulus		0.0074	0.0079	0.0463
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0055	0.004	0.0236
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0079	0.0453
Entamoeba histolytica	p21-activated kinase	0.0094	0.0119	0.0519
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0055	0.004	0.0018
Entamoeba histolytica	PH domain containing protein	0.0074	0.0079	0.0254
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0074	0.0079	0.0453
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0055	0.004	0.0031
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0055	0.004	0.0026
Brugia malayi	hypothetical protein	0.037	0.0681	0.0668
Loa Loa (eye worm)	AUR protein kinase	0.0081	0.0093	0.0091
Brugia malayi	PXA domain containing protein	0.0803	0.1562	0.155
Echinococcus multilocularis	aurora kinase A	0.0081	0.0093	0.0095
Loa Loa (eye worm)	PXA domain-containing protein	0.0803	0.1562	0.156
Entamoeba histolytica	protein kinase, putative	0.0094	0.0119	0.0519
Leishmania major	protein kinase, putative	0.0075	0.0081	0.5105
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Trichomonas vaginalis	AGC family protein kinase	0.0081	0.0093	0.0546
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0055	0.004	0.0031
Echinococcus granulosus	expressed protein	0.0803	0.1562	0.1853
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.4151	0.8367	1
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Echinococcus granulosus	regulator of G protein signaling 7	0.0803	0.1562	0.1853
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Schistosoma mansoni	vav2	0.0074	0.0079	0.0057
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0151	0.0236	0.0233
Echinococcus granulosus	c src tyrosine kinase	0.0055	0.004	0.0031
Onchocerca volvulus	Putative zinc finger protein	0.0074	0.0079	0.0463
Loa Loa (eye worm)	TK/ACK protein kinase	0.0055	0.004	0.0037
Brugia malayi	SH2 domain containing protein	0.0055	0.004	0.0026
Schistosoma mansoni	regulator of G protein signaling	0.0803	0.1562	0.1543
Schistosoma mansoni	protein kinase	0.0055	0.004	0.0018
Schistosoma mansoni	serine/threonine protein kinase	0.3797	0.7649	0.7643
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0074	0.0079	0.0254
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0079	0.0453
Schistosoma mansoni	hypothetical protein	0.0074	0.0079	0.0057
Trichomonas vaginalis	TKL family protein kinase	0.0055	0.004	0.0204
Loa Loa (eye worm)	rho-GTPase-activating	0.0074	0.0079	0.0076
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Loa Loa (eye worm)	hypothetical protein	0.037	0.0681	0.0679
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0055	0.004	0.0031
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0055	0.004	0.0018
Echinococcus granulosus	DCC interacting protein 13 beta	0.0074	0.0079	0.0078
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0074	0.0079	0.4895
Brugia malayi	PH domain containing protein	0.0074	0.0079	0.0065
Schistosoma mansoni	dynamin	0.0074	0.0079	0.0057
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0074	0.0079	0.0078
Echinococcus granulosus	epidermal growth factor receptor	0.0055	0.004	0.0031
Echinococcus multilocularis	Pleckstrin y	0.0074	0.0079	0.0078
Brugia malayi	serine/threonine-protein kinase 6	0.0081	0.0093	0.0079
Echinococcus multilocularis	regulator of G protein signaling 3	0.0803	0.1562	0.1853
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0119	0.0712
Echinococcus multilocularis	c src tyrosine kinase	0.0055	0.004	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0055	0.004	0.0037
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0055	0.004	0.0031
Loa Loa (eye worm)	TK protein kinase	0.0055	0.004	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0055	0.004	0.0037
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.4151	0.8367	0.8367
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0074	0.0079	0.0453
Echinococcus multilocularis	Oxysterol binding protein 11	0.0074	0.0079	0.0078
Brugia malayi	MAX-1A	0.0074	0.0079	0.0065
Loa Loa (eye worm)	TK/FER protein kinase	0.0055	0.004	0.0037
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0074	0.0079	0.0463
Loa Loa (eye worm)	hypothetical protein	0.037	0.0681	0.0679
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0094	0.0119	0.0519
Echinococcus granulosus	Rho GTPase activating protein 24	0.0074	0.0079	0.0078
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0079	0.0076
Toxoplasma gondii	AtPH1 family protein	0.0074	0.0079	0.4895
Schistosoma mansoni	serine/threonine protein kinase	0.0081	0.0093	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0124	0.0122
Echinococcus granulosus	tyrosine kinase	0.0055	0.004	0.0031
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0055	0.004	0.0031
Echinococcus multilocularis	integrin linked protein kinase	0.0055	0.004	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0182	0.03	0.0297
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0055	0.004	0.0026
Echinococcus granulosus	raf serine:threonine protein kinase	0.0055	0.004	0.0031
Echinococcus multilocularis	tyrosine protein kinase csk	0.0055	0.004	0.0031
Schistosoma mansoni	hypothetical protein	0.0055	0.004	0.0018
Trypanosoma cruzi	PH domain containing protein, putative	0.0074	0.0079	0.4895
Schistosoma mansoni	serine/threonine-protein kinase	0.0094	0.0119	0.0097
Loa Loa (eye worm)	TK/ABL protein kinase	0.0055	0.004	0.0037
Echinococcus granulosus	axis inhibition protein axin	0.0803	0.1562	0.1853
Echinococcus granulosus	regulator of G protein signaling 7	0.0803	0.1562	0.1853
Onchocerca volvulus	Protein melted homolog	0.0074	0.0079	0.0463
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0055	0.004	0.0037
Brugia malayi	PH domain containing protein	0.0074	0.0079	0.0065
Schistosoma mansoni	tyrosine kinase	0.0055	0.004	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0162	0.0259	0.161
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0055	0.004	0.0031
Echinococcus multilocularis	semaphorin 5B	0.037	0.0681	0.0799
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0055	0.004	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0259	0.0256
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0055	0.004	0.0031
Trichomonas vaginalis	kinesin light chain, putative	0.0074	0.0079	0.0453
Brugia malayi	Pleckstrin Homology Domain	0.0074	0.0079	0.0065
Schistosoma mansoni	vesicular amine transporter	0.0099	0.013	0.0108
Schistosoma mansoni	protein tyrosine kinase	0.0055	0.004	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0803	0.1562	0.156
Brugia malayi	Raf kinase	0.0055	0.004	0.0026
Loa Loa (eye worm)	TK protein kinase	0.0055	0.004	0.0037
Plasmodium falciparum	PH domain-containing protein, putative	0.0074	0.0079	0.4895
Echinococcus multilocularis	insulin receptor	0.0055	0.004	0.0031
Echinococcus multilocularis	tyrosine kinase	0.0055	0.004	0.0031

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 6.3096 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 6.3096 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	20.5962 uM	PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Hemoglobin Beta Chain Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))]	ChEMBL.	No reference
Potency (functional)	= 56.2341 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1549473

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1414676