Detailed information for compound 1414893

Basic information

Technical information
  • TDR Targets ID: 1414893
  • Name: butyl 4-[(3-amino-4,6-dimethylthieno[5,4-b]py ridine-2-carbonyl)amino]benzoate
  • MW: 397.491 | Formula: C21H23N3O3S
  • H donors: 2 H acceptors: 3 LogP: 5.11 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCOC(=O)c1ccc(cc1)NC(=O)c1sc2c(c1N)c(C)cc(n2)C
  • InChi: 1S/C21H23N3O3S/c1-4-5-10-27-21(26)14-6-8-15(9-7-14)24-19(25)18-17(22)16-12(2)11-13(3)23-20(16)28-18/h6-9,11H,4-5,10,22H2,1-3H3,(H,24,25)
  • InChiKey: ZHRWTGQQFIGOKS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • butyl 4-[(3-amino-4,6-dimethyl-thieno[5,4-b]pyridine-2-carbonyl)amino]benzoate
  • 4-[[(3-amino-4,6-dimethyl-2-thieno[5,4-b]pyridinyl)-oxomethyl]amino]benzoic acid butyl ester
  • 4-[(3-amino-4,6-dimethyl-thieno[5,4-b]pyridine-2-carbonyl)amino]benzoic acid butyl ester
  • butyl 4-[(3-amino-4,6-dimethyl-thieno[5,4-b]pyridin-2-yl)carbonylamino]benzoate
  • NCGC00101836-01
  • ZINC01871177
  • SBB015997

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens relaxin/insulin-like family peptide receptor 1 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0056 0.007 0.007
Plasmodium vivax PH domain containing protein 0.0069 0.0099 0.4164
Loa Loa (eye worm) hypothetical protein 0.0753 0.1579 0.1579
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Schistosoma mansoni serine/threonine RGC 0.0056 0.007 0.007
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.007 0.0174
Trichomonas vaginalis protein transport protein sec7, putative 0.0069 0.0099 0.055
Echinococcus granulosus twitchin 0.0134 0.0239 0.0286
Echinococcus granulosus aurora kinase A 0.0079 0.012 0.0144
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.007 0.0174
Entamoeba histolytica hypothetical protein 0.0753 0.1579 1
Trypanosoma cruzi hypothetical protein 0.0069 0.0099 0.5814
Loa Loa (eye worm) RGC/RGC protein kinase 0.0056 0.007 0.007
Onchocerca volvulus 0.0069 0.0099 0.0544
Loa Loa (eye worm) hypothetical protein 0.016 0.0295 0.0295
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Trichomonas vaginalis centaurin gamma, putative 0.0069 0.0099 0.055
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.007 0.007
Echinococcus granulosus Oxysterol binding protein 11 0.0069 0.0099 0.0118
Brugia malayi A-kinase anchor protein 10, precursor 0.0753 0.1579 0.1579
Entamoeba histolytica protein kinase, putative 0.0056 0.007 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0036 0.0154
Echinococcus granulosus epidermal growth factor receptor 0.0056 0.007 0.0083
Giardia lamblia Kinase 0.0056 0.007 0.0606
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Trichomonas vaginalis conserved hypothetical protein 0.016 0.0295 0.1807
Onchocerca volvulus 0.0056 0.007 0.0386
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0099 0.055
Loa Loa (eye worm) hypothetical protein 0.0753 0.1579 0.1579
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0099 0.055
Trichomonas vaginalis AGC family protein kinase 0.0056 0.007 0.0367
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0056 0.007 0.0083
Echinococcus granulosus raf serine:threonine protein kinase 0.0056 0.007 0.0083
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.007 0.007
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.007 0.0174
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.012 0.021 0.021
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Schistosoma mansoni protein kinase 0.0056 0.007 0.007
Echinococcus granulosus calcium dependent secretion activator 1 0.0069 0.0099 0.0118
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0088 0.0139 1
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.007 0.0174
Loa Loa (eye worm) hypothetical protein 0.012 0.021 0.021
Brugia malayi MAX-1A 0.0069 0.0099 0.0099
Loa Loa (eye worm) TK protein kinase 0.0056 0.007 0.007
Schistosoma mansoni tyrosine protein kinase 0.0056 0.007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0099 0.055
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.007 0.0367
Trichomonas vaginalis conserved hypothetical protein 0.016 0.0295 0.1807
Brugia malayi protein-tyrosine kinase 0.0056 0.007 0.007
Echinococcus multilocularis pleckstrin y domain containing family A 0.0069 0.0099 0.0118
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0056 0.007 0.007
Onchocerca volvulus 0.0029 0.0012 0.0065
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Loa Loa (eye worm) TK protein kinase 0.0056 0.007 0.007
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Schistosoma mansoni cell adhesion molecule 0.012 0.021 0.021
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0043 0.3029
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.007 0.0174
Brugia malayi Variant SH3 domain containing protein 0.0069 0.0099 0.0099
Echinococcus granulosus beta-adrenergic receptor kinase 0.3558 0.7653 0.9143
Brugia malayi Guanylyl cyclase protein 23 0.0056 0.007 0.007
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0069 0.0099 0.0544
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Brugia malayi Raf kinase 0.0056 0.007 0.007
Loa Loa (eye worm) TK/ACK protein kinase 0.0056 0.007 0.007
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Schistosoma mansoni hypothetical protein 0.0069 0.0099 0.0099
Brugia malayi Pleckstrin Homology Domain 0.0069 0.0099 0.0099
Entamoeba histolytica PH domain containing protein 0.0069 0.0099 0.0361
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0056 0.007 0.0083
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Echinococcus granulosus protein kinase 0.0056 0.007 0.0083
Entamoeba histolytica hypothetical protein, conserved 0.0056 0.007 0.0174
Entamoeba histolytica PH domain containing protein 0.0069 0.0099 0.0361
Echinococcus granulosus semaphorin 5B 0.0365 0.074 0.0884
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0088 0.0139 1
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.007 0.0174
Echinococcus multilocularis expressed conserved protein 0.0024 0.0001 0.0001
Brugia malayi hypothetical protein 0.0753 0.1579 0.1579
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0056 0.007 0.0083
Brugia malayi Tyrosine-protein kinase abl-1 0.0056 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0115 0.0199 0.0199
Trypanosoma brucei protein kinase, putative 0.0074 0.011 0.7859
Plasmodium falciparum tyrosine kinase-like protein 0.0056 0.007 0.5
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0069 0.0099 0.5814
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.007 0.0174
Schistosoma mansoni protein kinase 0.0056 0.007 0.007
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.007 0.0174
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.007 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0028 0.0099
Schistosoma mansoni hypothetical protein 0.0043 0.0043 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0056 0.007 0.007
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0069 0.0099 0.0361
Brugia malayi Cadps2 protein 0.0069 0.0099 0.0099
Entamoeba histolytica hypothetical protein 0.0069 0.0099 0.0361
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.007 0.007
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0043 0.0052
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Plasmodium falciparum oxysterol-binding protein, putative 0.0069 0.0099 0.7082
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0056 0.007 0.0083
Entamoeba histolytica PH domain containing protein 0.0069 0.0099 0.0361
Echinococcus multilocularis tyrosine protein kinase pr2 0.0056 0.007 0.0083
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0088 0.0139 1
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Brugia malayi Oxysterol binding protein 0.0069 0.0099 0.0099
Schistosoma mansoni protein kinase 0.0079 0.012 0.012
Brugia malayi serine/threonine kinase 12 0.0079 0.012 0.012
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0069 0.0099 0.0361
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0099
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0088 0.0139 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.007 0.0174
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0069 0.0099 0.0361
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Brugia malayi PH domain containing protein 0.0069 0.0099 0.0099
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.007 0.0174
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Loa Loa (eye worm) hypothetical protein 0.0056 0.007 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.007 0.007
Schistosoma mansoni dynamin 0.0069 0.0099 0.0099
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.007 0.007
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0056 0.007 0.0083
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0495 0.1021 0.1021
Schistosoma mansoni protein kinase 0.0074 0.011 0.011
Echinococcus granulosus myotubularin protein 13 0.0069 0.0099 0.0118
Trypanosoma cruzi hypothetical protein 0.0069 0.0099 0.5814
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0099 0.055
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0099
Entamoeba histolytica protein kinase, putative 0.0056 0.007 0.0174
Entamoeba histolytica hypothetical protein 0.016 0.0295 0.1643
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0036 0.0154
Schistosoma mansoni axis inhibition protein axin 0.0753 0.1579 0.1579
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0753 0.1579 0.1886
Loa Loa (eye worm) hypothetical protein 0.0365 0.074 0.074
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Echinococcus multilocularis tyrosine protein kinase csk 0.0056 0.007 0.0083
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Brugia malayi Probable exocyst complex component Sec5 0.016 0.0295 0.0295
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.003 0.0114
Entamoeba histolytica serine/threonine kinase, putative 0.0056 0.007 0.0174
Loa Loa (eye worm) TK protein kinase 0.0056 0.007 0.007
Trypanosoma cruzi PH domain containing protein, putative 0.0069 0.0099 0.5814
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Trichomonas vaginalis kinesin light chain, putative 0.0069 0.0099 0.055
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.007 0.0174
Echinococcus multilocularis myotubularin protein 13 0.0069 0.0099 0.0118
Schistosoma mansoni hypothetical protein 0.0069 0.0099 0.0099
Entamoeba histolytica protein kinase, putative 0.0056 0.007 0.0174
Loa Loa (eye worm) hypothetical protein 0.0365 0.074 0.074
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0088 0.0139 1
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0069 0.0099 0.0099
Brugia malayi Protein kinase domain containing protein 0.0088 0.0139 0.0139
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0069 0.0099 0.055
Onchocerca volvulus 0.0069 0.0099 0.0544
Echinococcus granulosus dynamin 1 0.0069 0.0099 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0019 0.0039
Echinococcus multilocularis tyrosine protein kinase Blk 0.0056 0.007 0.0083
Loa Loa (eye worm) TK protein kinase 0.0056 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.016 0.0295 0.0295
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0753 0.1579 0.1579
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0099 0.055
Loa Loa (eye worm) hypothetical protein 0.0115 0.0199 0.0199
Loa Loa (eye worm) syntrophin-1 0.0069 0.0099 0.0099
Entamoeba histolytica serine/threonine kinase, putative 0.0056 0.007 0.0174
Schistosoma mansoni goodpasture antigen-binding protein 0.0069 0.0099 0.0099
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.007 0.0083
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0056 0.007 0.0083
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Entamoeba histolytica protein kinase, putative 0.0088 0.0139 0.0623
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Brugia malayi probable spectrin beta chain 0.0069 0.0099 0.0099
Entamoeba histolytica hypothetical protein 0.0056 0.007 0.0176
Schistosoma mansoni hypothetical protein 0.0365 0.074 0.074
Plasmodium falciparum calcium-dependent protein kinase 7 0.0088 0.0139 1
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0069 0.0099 0.0118
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.007 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0099 0.055
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0025 0.0083
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Onchocerca volvulus 0.0056 0.007 0.0386
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0099 0.055
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0025
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Echinococcus granulosus tyrosine protein kinase csk 0.0056 0.007 0.0083
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0753 0.1579 0.1579
Echinococcus granulosus tumor protein p63 0.0408 0.0833 0.0995
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0069 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0099
Echinococcus multilocularis protein tyrosine kinase 0.0056 0.007 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.016 0.0295 0.1807
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0099
Echinococcus multilocularis hypothetical protein 0.0365 0.074 0.0884
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0056 0.007 0.0386
Trypanosoma cruzi hypothetical protein 0.0069 0.0099 0.5814
Schistosoma mansoni protein kinase 0.0056 0.007 0.007
Brugia malayi serine/threonine protein kinase 6 0.0079 0.012 0.012
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.016 0.0295 0.1807
Entamoeba histolytica ankyrin repeat protein 0.0056 0.007 0.0174
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Trichomonas vaginalis conserved hypothetical protein 0.016 0.0295 0.1807
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0099
Echinococcus granulosus transcription factor collier 0.016 0.0295 0.0353
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Echinococcus granulosus regulator of G protein signaling 7 0.0753 0.1579 0.1886
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Entamoeba histolytica protein kinase, putative 0.0088 0.0139 0.0623
Schistosoma mansoni vesicular amine transporter 0.0118 0.0205 0.0205
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.007 0.0174
Schistosoma mansoni hypothetical protein 0.0029 0.0012 0.0012
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0069 0.0099 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0099 0.055
Schistosoma mansoni centaurin alpha 0.0069 0.0099 0.0099
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0044 0.0044
Echinococcus multilocularis ephrin type A receptor 4 A 0.0056 0.007 0.0083
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.0067 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0019 0.0039
Trichomonas vaginalis alpha chimerin, putative 0.0069 0.0099 0.055
Entamoeba histolytica protein kinase, putative 0.0056 0.007 0.0174
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0069 0.0099 0.055
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0069 0.0099 0.0118
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.007 0.0174
Brugia malayi Furin-like cysteine rich region family protein 0.0056 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0753 0.1579 0.1579
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.3558 0.7653 0.7653
Entamoeba histolytica hypothetical protein 0.0069 0.0099 0.0361
Trichomonas vaginalis AGC family protein kinase 0.0079 0.012 0.0689
Echinococcus granulosus regulator of G protein signaling 3 0.0753 0.1579 0.1886
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Echinococcus multilocularis tyrosine protein kinase csk 0.0056 0.007 0.0083
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0069 0.0099 0.7082
Echinococcus granulosus MAM 0.0029 0.0012 0.0014
Schistosoma mansoni serine/threonine-protein kinase 0.0088 0.0139 0.0139
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.3889 0.837 0.837
Brugia malayi Regulator of G protein signaling domain containing protein 0.0753 0.1579 0.1579
Trichomonas vaginalis conserved hypothetical protein 0.0753 0.1579 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0056 0.007 0.0083
Giardia lamblia Kinase, NEK 0.0056 0.007 0.0606
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.007 0.007
Entamoeba histolytica hypothetical protein, conserved 0.0069 0.0099 0.0361
Onchocerca volvulus 0.0069 0.0099 0.0544
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.007 0.0174
Trichomonas vaginalis hypothetical protein 0.0069 0.0099 0.055
Entamoeba histolytica PH domain containing protein kinase, putative 0.0088 0.0139 0.0623
Brugia malayi Oxysterol-binding protein 0.0069 0.0099 0.0099
Entamoeba histolytica protein kinase, putative 0.0056 0.007 0.0174
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0069 0.0099 0.5814
Brugia malayi SRC-1 0.0056 0.007 0.007
Echinococcus granulosus GRB2 associated binding protein 3 0.0069 0.0099 0.0118
Brugia malayi hypothetical protein 0.0043 0.0043 0.0043
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0056 0.007 0.0083
Echinococcus granulosus neuroglian 0.0115 0.0199 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0753 0.1579 1
Entamoeba histolytica hypothetical protein 0.0056 0.007 0.0174
Brugia malayi Immunoglobulin I-set domain containing protein 0.0056 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0099
Echinococcus multilocularis natriuretic peptide receptor 1 0.0056 0.007 0.0083
Echinococcus granulosus natriuretic peptide receptor 1 0.0056 0.007 0.0083
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Trichomonas vaginalis protein kinase atn1, putative 0.0056 0.007 0.0367
Entamoeba histolytica hypothetical protein 0.0056 0.007 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0043 0.0192
Schistosoma mansoni hypothetical protein 0.0069 0.0099 0.0099
Echinococcus granulosus axis inhibition protein axin 0.0753 0.1579 0.1886
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0088 0.0139 1
Leishmania major hypothetical protein, conserved 0.0069 0.0099 0.7082
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.007 0.0174
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0365 0.074 0.074
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.007 0.007
Echinococcus multilocularis G protein coupled receptor kinase 6 0.3889 0.837 1
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0078 0.0078
Trypanosoma cruzi hypothetical protein 0.0069 0.0099 0.5814
Onchocerca volvulus 0.006 0.0078 0.0433
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0088 0.0139 0.0807
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0069 0.0099 0.0544
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Entamoeba histolytica hypothetical protein 0.0056 0.007 0.0174
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0056 0.007 0.0083
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Echinococcus granulosus tyrosine protein kinase pr2 0.0056 0.007 0.0083
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0036 0.0043
Entamoeba histolytica protein kinase, putative 0.0056 0.007 0.0174
Leishmania major protein kinase, putative 0.0074 0.011 0.7918
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0056 0.007 0.007
Loa Loa (eye worm) RGC/RGC protein kinase 0.0056 0.007 0.007
Echinococcus granulosus retinal guanylyl cyclase 2 0.0056 0.007 0.0083
Echinococcus multilocularis transcription factor collier 0.016 0.0295 0.0353
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0088 0.0139 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0012 0.0012
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0056 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0056 0.007 0.007
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0069 0.0099 0.0361
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0036 0.0043
Echinococcus multilocularis tumor protein p63 0.0408 0.0833 0.0995
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0753 0.1579 0.1886
Entamoeba histolytica serine/threonine kinase, putative 0.0056 0.007 0.0174
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Loa Loa (eye worm) TK/CSK protein kinase 0.0056 0.007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0099 0.055
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.007 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0019 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0019 0.0044
Echinococcus granulosus tyrosine protein kinase Blk 0.0056 0.007 0.0083
Loa Loa (eye worm) PXA domain-containing protein 0.0753 0.1579 0.1579
Giardia lamblia Kinase, NEK 0.0056 0.007 0.0606
Brugia malayi PXA domain containing protein 0.0753 0.1579 0.1579
Echinococcus granulosus DCC interacting protein 13 beta 0.0069 0.0099 0.0118
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Echinococcus granulosus plexin a4 0.102 0.2158 0.2578
Entamoeba histolytica protein kinase, putative 0.0088 0.0139 0.0623
Entamoeba histolytica tyrosin kinase, putative 0.0056 0.007 0.0174
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Brugia malayi Dynamin 0.0069 0.0099 0.0099
Toxoplasma gondii AtPH1 family protein 0.0069 0.0099 0.7082
Loa Loa (eye worm) TK/EGFR protein kinase 0.0056 0.007 0.007
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0069 0.0099 0.7082
Echinococcus multilocularis actin binding protein anillin 0.0069 0.0099 0.0118
Loa Loa (eye worm) hypothetical protein 0.0365 0.074 0.074
Trichomonas vaginalis conserved hypothetical protein 0.0753 0.1579 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0056 0.007 0.007
Schistosoma mansoni protein kinase 0.0056 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0753 0.1579 0.1579
Onchocerca volvulus 0.086 0.1811 1
Loa Loa (eye worm) AUR protein kinase 0.0079 0.012 0.012
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.007 0.007
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Entamoeba histolytica hypothetical protein 0.0069 0.0099 0.0361
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0056 0.007 0.007
Brugia malayi regulator of G-protein signaling rgs-7 0.0753 0.1579 0.1579
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0069 0.0099 0.0099
Echinococcus granulosus c src tyrosine kinase 0.0056 0.007 0.0083
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0753 0.1579 1
Toxoplasma gondii Oxysterol-binding protein 0.0069 0.0099 0.7082
Brugia malayi IPT/TIG domain containing protein 0.016 0.0295 0.0295
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0056 0.007 0.0083
Trichomonas vaginalis centaurin/arf, putative 0.0069 0.0099 0.055
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.3889 0.837 1
Onchocerca volvulus 0.0056 0.007 0.0386
Loa Loa (eye worm) hypothetical protein 0.0029 0.0012 0.0012
Entamoeba histolytica serine/threonine kinase, putative 0.0056 0.007 0.0174
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0056 0.007 0.007
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.3889 0.837 0.837
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Trypanosoma cruzi hypothetical protein 0.0069 0.0099 0.5814
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0056 0.007 0.0176
Echinococcus granulosus Pleckstrin y 0.0069 0.0099 0.0118
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0056 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0069 0.0099 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Onchocerca volvulus 0.0056 0.007 0.0386
Loa Loa (eye worm) hypothetical protein 0.0115 0.0199 0.0199
Onchocerca volvulus Putative zinc finger protein 0.0069 0.0099 0.0544
Trichomonas vaginalis conserved hypothetical protein 0.0753 0.1579 1
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0043 0.0043
Entamoeba histolytica hypothetical protein 0.0753 0.1579 1
Loa Loa (eye worm) hypothetical protein 0.016 0.0295 0.0295
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0056 0.007 0.0083
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0061 0.0081 0.0096
Entamoeba histolytica protein kinase, putative 0.0056 0.007 0.0174
Echinococcus multilocularis receptor type guanylyl cyclase 0.0056 0.007 0.0083
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0043 0.0192
Echinococcus granulosus G protein coupled receptor kinase 1 0.2805 0.6024 0.7196
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.007 0.0174
Echinococcus granulosus oxysterol binding protein 1 0.0069 0.0099 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.007 0.007
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Echinococcus multilocularis regulator of G protein signaling 0.0753 0.1579 0.1886
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0069 0.0099 0.0361
Echinococcus granulosus tyrosine protein kinase Src64B 0.0056 0.007 0.0083
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.007 0.007
Trypanosoma cruzi PH domain containing protein, putative 0.0069 0.0099 0.5814
Brugia malayi Immunoglobulin I-set domain containing protein 0.0171 0.032 0.032
Echinococcus granulosus retinal guanylyl cyclase 2 0.0056 0.007 0.0083
Entamoeba histolytica protein kinase, putative 0.0056 0.007 0.0174
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.007 0.0174
Entamoeba histolytica ankyrin repeat protein 0.0056 0.007 0.0174
Brugia malayi Tyrosine-protein kinase PR2 0.0056 0.007 0.007
Echinococcus multilocularis roundabout 2 0.012 0.021 0.025
Trypanosoma brucei Pseudokinase, putative 0.0056 0.007 0.4858
Leishmania major protein kinase, putative 0.0088 0.0139 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0074 0.011 0.0132
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0056 0.007 0.0083
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.007 0.007
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0056 0.007 0.0083
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Onchocerca volvulus 0.0056 0.007 0.0386
Loa Loa (eye worm) hypothetical protein 0.0056 0.007 0.007
Schistosoma mansoni z-protein (S1r protein) 0.0753 0.1579 0.1579
Echinococcus multilocularis axis inhibition protein axin 0.0753 0.1579 0.1886
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0056 0.007 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0036 0.0154
Schistosoma mansoni hypothetical protein 0.016 0.0295 0.0295
Trypanosoma cruzi hypothetical protein 0.0069 0.0099 0.5814
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.007 0.0174
Schistosoma mansoni plexin 0.0495 0.1021 0.1021
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0121 0.0211 0.0252
Echinococcus multilocularis Immunoglobulin 0.0115 0.0199 0.0238
Echinococcus multilocularis beta adrenergic receptor kinase 0.3558 0.7653 0.9143
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0069 0.0099 0.7082
Echinococcus multilocularis Regulator of G protein signaling 20 0.0753 0.1579 0.1886
Schistosoma mansoni axis inhibition protein axin 0.0753 0.1579 0.1579
Entamoeba histolytica PH domain containing protein kinase, putative 0.0088 0.0139 0.0623
Leishmania major serine/threonine-protein kinase a, putative 0.0088 0.0139 1
Loa Loa (eye worm) uncoordinated protein 104 0.0069 0.0099 0.0099
Echinococcus multilocularis activated cdc42 kinase 1 0.0056 0.007 0.0083
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0056 0.007 0.0083
Brugia malayi Dynamin 0.0069 0.0099 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.016 0.0295 0.1807
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.007 0.007
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Loa Loa (eye worm) plexin A 0.102 0.2158 0.2158
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Loa Loa (eye worm) hypothetical protein 0.0115 0.0199 0.0199
Echinococcus multilocularis regulator of G protein signaling 3 0.0753 0.1579 0.1886
Loa Loa (eye worm) RGS-3 protein 0.0753 0.1579 0.1579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0013 0.0001
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0753 0.1579 0.1579
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.007 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0753 0.1579 1
Entamoeba histolytica protein kinase, putative 0.0088 0.0139 0.0623
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Entamoeba histolytica hypothetical protein 0.0056 0.007 0.0176
Plasmodium vivax hypothetical protein, conserved 0.0069 0.0099 0.4164
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Loa Loa (eye worm) hypothetical protein 0.0213 0.0411 0.0411
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.007 0.0367
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.012 0.012
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0061 0.0081 0.0096
Entamoeba histolytica cysteine surface protein, putative 0.0056 0.007 0.0174
Loa Loa (eye worm) hypothetical protein 0.0056 0.007 0.007
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0001 0.0001
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0067 0.4616
Echinococcus multilocularis Rho GTPase activating protein 24 0.0069 0.0099 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.007 0.007
Brugia malayi hypothetical protein 0.0753 0.1579 0.1579
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.007 0.0174
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0029 0.0012 0.0012
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0056 0.007 0.0083
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0069 0.0099 0.055
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.016 0.0295 0.1807
Echinococcus granulosus tyrosine protein kinase Srms 0.0056 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0013 0.0001
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0088 0.0139 1
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0079 0.012 0.0503
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Brugia malayi Receptor family ligand binding region containing protein 0.0056 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0099
Echinococcus multilocularis tyrosine kinase 0.0056 0.007 0.0083
Entamoeba histolytica protein kinase domain containing protein 0.0216 0.0416 0.2429
Loa Loa (eye worm) TK/FAK protein kinase 0.0056 0.007 0.007
Trypanosoma cruzi hypothetical protein 0.0069 0.0099 0.5814
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Echinococcus multilocularis protein KINase family member (kin 25) 0.0056 0.007 0.0083
Echinococcus multilocularis c src tyrosine kinase 0.0056 0.007 0.0083
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0024 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0099
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.007 0.0174
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0056 0.007 0.007
Echinococcus granulosus oxysterol binding protein 9 0.0069 0.0099 0.0118
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0069 0.0099 0.0118
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0056 0.007 0.0174
Schistosoma mansoni serine/threonine protein kinase 0.4641 1 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0056 0.007 0.0083
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0056 0.007 0.5
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0069 0.0099 0.4164
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0036 0.0154
Schistosoma mansoni protein kinase 0.0056 0.007 0.007
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0056 0.007 0.0367
Brugia malayi integrin-linked kinase 0.0056 0.007 0.007
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Brugia malayi hypothetical protein 0.0056 0.007 0.007
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0753 0.1579 1
Echinococcus granulosus cGMP dependent protein kinase 1 0.0024 0.0001 0.0001
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0069 0.0099 0.0118
Brugia malayi Sema domain containing protein 0.0365 0.074 0.074
Brugia malayi hypothetical protein 0.0365 0.074 0.074
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0069 0.0099 0.0361
Trypanosoma cruzi protein kinase, putative 0.0056 0.007 0.2828
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Echinococcus granulosus cytohesin 1 0.0069 0.0099 0.0118
Schistosoma mansoni protein kinase 0.0056 0.007 0.007
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.007 0.0174
Entamoeba histolytica protein kinase, putative 0.0079 0.012 0.0503
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0067 0.008
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0069 0.0099 0.0099
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.007 0.0174
Entamoeba histolytica serine/threonine kinase, putative 0.0056 0.007 0.0174
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0056 0.007 0.0083
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0056 0.007 0.4858
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Echinococcus multilocularis pdz domain containing protein 0.0069 0.0099 0.0118
Loa Loa (eye worm) hypothetical protein 0.006 0.0078 0.0078
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Onchocerca volvulus Protein melted homolog 0.0069 0.0099 0.0544
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0069 0.0099 0.0118
Echinococcus multilocularis aurora kinase A 0.0079 0.012 0.0144
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.007 0.0083
Loa Loa (eye worm) SRC-1 0.0056 0.007 0.007
Trichomonas vaginalis STE family protein kinase 0.0056 0.007 0.0367
Schistosoma mansoni hypothetical protein 0.016 0.0295 0.0295
Loa Loa (eye worm) RGC/RGC protein kinase 0.0056 0.007 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0043 0.0192
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0056 0.007 0.007
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Echinococcus granulosus cGMP dependent protein kinase 1 0.0024 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Trypanosoma cruzi PH domain containing protein, putative 0.0069 0.0099 0.5814
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0056 0.007 0.0083
Entamoeba histolytica tyrosin kinase, putative 0.0056 0.007 0.0174
Loa Loa (eye worm) TK protein kinase 0.0056 0.007 0.007
Loa Loa (eye worm) rho-GTPase-activating 0.0069 0.0099 0.0099
Entamoeba histolytica hypothetical protein 0.0056 0.007 0.0174
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0069 0.0099 0.055
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0069 0.0099 0.0118
Echinococcus multilocularis rac serine:threonine kinase 0.0088 0.0139 0.0166
Onchocerca volvulus Tyrosine kinase homolog 0.0056 0.007 0.0386
Entamoeba histolytica hypothetical protein 0.0056 0.007 0.0174
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0056 0.007 0.0083
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0056 0.007 0.007
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0069 0.0099 0.0361
Loa Loa (eye worm) TK/ABL protein kinase 0.0056 0.007 0.007
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0069 0.0099 0.0118
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Echinococcus multilocularis G protein coupled receptor kinase 1 0.2805 0.6024 0.7196
Loa Loa (eye worm) AGC/AKT protein kinase 0.0088 0.0139 0.0139
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.003 0.0114
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Loa Loa (eye worm) PH domain-containing protein 0.0069 0.0099 0.0099
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.4641 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0001 0.0001
Brugia malayi serine/threonine-protein kinase 6 0.0079 0.012 0.012
Loa Loa (eye worm) TK/INSR protein kinase 0.0056 0.007 0.007
Echinococcus granulosus tyrosine protein kinase 0.0056 0.007 0.0083
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Entamoeba histolytica hypothetical protein 0.0088 0.0139 0.0623
Entamoeba histolytica protein kinase , putative 0.0079 0.012 0.0503
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.007 0.0174
Loa Loa (eye worm) TK/Met protein kinase 0.0056 0.007 0.007
Brugia malayi Fibronectin type III domain containing protein 0.012 0.021 0.021
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0056 0.007 0.007
Schistosoma mansoni regulator of G protein signaling 0.0753 0.1579 0.1579
Trichomonas vaginalis protein transport protein sec7, putative 0.0069 0.0099 0.055
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0056 0.007 0.007
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.007 0.0174
Entamoeba histolytica protein kinase, putative 0.0079 0.012 0.0503
Echinococcus multilocularis MAM 0.0029 0.0012 0.0014
Echinococcus multilocularis raf serine:threonine protein kinase 0.0056 0.007 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.007 0.0367
Echinococcus multilocularis expressed protein 0.0753 0.1579 0.1886
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0056 0.007 0.007
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.007 0.0083
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0067 0.4616
Leishmania major hypothetical protein, conserved 0.0069 0.0099 0.7082
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0069 0.0099 0.0099
Trypanosoma brucei aurora B kinase 0.0079 0.012 0.862
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0069 0.0099 0.7082
Plasmodium falciparum protein kinase, putative 0.0056 0.007 0.5
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0056 0.007 0.0083
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0056 0.007 0.0174
Schistosoma mansoni regulator of G protein signaling 0.0753 0.1579 0.1579
Entamoeba histolytica protein kinase, putative 0.0056 0.007 0.0174
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0056 0.007 0.0083
Brugia malayi Plexin repeat family protein 0.086 0.1811 0.1811
Loa Loa (eye worm) TK protein kinase 0.0056 0.007 0.007
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0056 0.007 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0013 0.0001
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0056 0.007 0.0367
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0013 0.0001
Echinococcus multilocularis protein kinase 0.0056 0.007 0.0083
Echinococcus granulosus serine/threonine protein kinase 0.0088 0.0139 0.0166
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Brugia malayi SH2 domain containing protein 0.0056 0.007 0.007
Schistosoma mansoni serine/threonine-protein kinase 0.0088 0.0139 0.0139
Onchocerca volvulus 0.0365 0.074 0.4083
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.007 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.007 0.007
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.007 0.0174
Trichomonas vaginalis AGC family protein kinase 0.0079 0.012 0.0689
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0056 0.007 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0099 0.055
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0099 0.055
Brugia malayi TBC domain containing protein 0.0069 0.0099 0.0099
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.016 0.0295 0.1807
Echinococcus granulosus receptor type guanylyl cyclase 0.0056 0.007 0.0083
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0056 0.007 0.0083
Echinococcus granulosus Rho GTPase activating protein 24 0.0069 0.0099 0.0118
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0069 0.0099 0.0118
Entamoeba histolytica ARF GTPase activating protein, putative 0.0069 0.0099 0.0361
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.007 0.0174
Onchocerca volvulus 0.0056 0.007 0.0386
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0056 0.007 0.0083
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.011 0.0436
Entamoeba histolytica hypothetical protein 0.016 0.0295 0.1643
Brugia malayi PH domain containing protein 0.0069 0.0099 0.0099
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.007 0.0174
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0067 0.2489
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Entamoeba histolytica protein kinase, putative 0.0056 0.007 0.0174
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0056 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0056 0.007 0.007
Toxoplasma gondii STE kinase 0.0056 0.007 0.5
Echinococcus granulosus roundabout 2 0.012 0.021 0.025
Trichomonas vaginalis centaurin beta, putative 0.0069 0.0099 0.055
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0069 0.0099 0.0118
Echinococcus granulosus oxysterol binding protein 3 0.0069 0.0099 0.0118
Toxoplasma gondii hypothetical protein 0.0069 0.0099 0.7082
Echinococcus granulosus Pleckstrin y 0.0069 0.0099 0.0118
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0043 0.0192
Loa Loa (eye worm) sema domain-containing protein 0.0365 0.074 0.074
Echinococcus granulosus integrin linked protein kinase 0.0056 0.007 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Loa Loa (eye worm) hypothetical protein 0.0056 0.007 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.007 0.007
Entamoeba histolytica PH domain containing protein kinase, putative 0.0088 0.0139 0.0623
Loa Loa (eye worm) TK protein kinase 0.0056 0.007 0.007
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0043 0.2831
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0099
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0115 0.0199 0.0238
Entamoeba histolytica hypothetical protein 0.0056 0.007 0.0174
Echinococcus granulosus activated cdc42 kinase 1 0.0056 0.007 0.0083
Echinococcus granulosus defective proboscis extension response 0.0115 0.0199 0.0238
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Brugia malayi PXA domain containing protein 0.0753 0.1579 0.1579
Brugia malayi hypothetical protein 0.0056 0.007 0.007
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Brugia malayi PH domain containing protein 0.0069 0.0099 0.0099
Echinococcus granulosus pdz domain containing protein 0.0069 0.0099 0.0118
Brugia malayi DNA-binding protein LAG-1 0.016 0.0295 0.0295
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0088 0.0139 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.0067 0.0153
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0069 0.0099 0.0361
Loa Loa (eye worm) hypothetical protein 0.0056 0.007 0.007
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0099 0.055
Brugia malayi Syntrophin-1 0.0069 0.0099 0.0099
Echinococcus granulosus beta 1 syntrophin 0.0069 0.0099 0.0118
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0115 0.0199 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0099 0.055
Trypanosoma cruzi Protein kinase B 0.0088 0.0139 1
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.007 0.007
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.007 0.0174
Echinococcus multilocularis oxysterol binding protein 3 0.0069 0.0099 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0036 0.0154
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0074 0.011 0.0132
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0067 0.4764
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0074 0.011 0.0132
Loa Loa (eye worm) oxysterol binding protein 0.0069 0.0099 0.0099
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0074 0.011 0.7014
Entamoeba histolytica hypothetical protein 0.0056 0.007 0.0174
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0056 0.007 0.0083
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0069 0.0099 0.0118
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0067 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0067 0.0346
Echinococcus granulosus regulator of G protein signaling 7 0.0753 0.1579 0.1886
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Onchocerca volvulus 0.0056 0.007 0.0386
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0079 0.012 0.0503
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0069 0.0099 0.0118
Echinococcus granulosus regulator of G protein signaling 3 0.0753 0.1579 0.1886
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Brugia malayi Egg laying defective protein 4 0.0024 0.0001 0.0001
Echinococcus granulosus tyrosine protein kinase shark 0.0056 0.007 0.0083
Schistosoma mansoni regulator of G protein signaling 0.0753 0.1579 0.1579
Entamoeba histolytica hypothetical protein 0.016 0.0295 0.1643
Loa Loa (eye worm) RGC/RGC protein kinase 0.0056 0.007 0.007
Brugia malayi SH2 domain containing protein 0.0056 0.007 0.007
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Leishmania major protein kinase, putative 0.0088 0.0139 1
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0088 0.0139 1
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0069 0.0099 0.0361
Schistosoma mansoni plexin 0.086 0.1811 0.1811
Schistosoma mansoni zinc finger protein 0.0069 0.0099 0.0099
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0056 0.007 0.007
Entamoeba histolytica hypothetical protein 0.0056 0.007 0.0176
Onchocerca volvulus 0.0056 0.007 0.0386
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0067 0.0067
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.007 0.0083
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0069 0.0099 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0036 0.0154
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Loa Loa (eye worm) hypothetical protein 0.086 0.1811 0.1811
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0069 0.0099 0.4164
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0088 0.0139 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0056 0.007 0.0083
Brugia malayi ephrin receptor 1 precursor 0.0056 0.007 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0036 0.0154
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.007 0.0174
Schistosoma mansoni ephrin receptor 0.0061 0.0081 0.0081
Echinococcus granulosus Pleckstrin y 0.0069 0.0099 0.0118
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.007 0.0174
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0099
Loa Loa (eye worm) cytohesin 3 0.0069 0.0099 0.0099
Onchocerca volvulus 0.0056 0.007 0.0386
Loa Loa (eye worm) TK protein kinase 0.0056 0.007 0.007
Onchocerca volvulus 0.0056 0.007 0.0386
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0056 0.007 0.0083
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0079 0.012 0.0144
Entamoeba histolytica tyrosin kinase, putative 0.0056 0.007 0.0174
Schistosoma mansoni ephrin receptor 0.0056 0.007 0.007
Onchocerca volvulus 0.0069 0.0099 0.0544
Loa Loa (eye worm) hypothetical protein 0.0056 0.007 0.007
Echinococcus multilocularis integrin linked protein kinase 0.0056 0.007 0.0083
Echinococcus granulosus activin receptor type 0.0074 0.011 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0043 0.0192
Brugia malayi PH domain containing protein 0.0069 0.0099 0.0099
Echinococcus multilocularis FL cytokine receptor 0.0056 0.007 0.0083
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0056 0.007 0.007
Echinococcus multilocularis Ras associated and pleckstrin y 0.0069 0.0099 0.0118
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Entamoeba histolytica protein kinase, putative 0.0056 0.007 0.0174
Onchocerca volvulus 0.0056 0.007 0.0386
Loa Loa (eye worm) AUR protein kinase 0.0079 0.012 0.012
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Trypanosoma cruzi NIMA-related kinase, putative 0.0088 0.0139 1
Loa Loa (eye worm) sema domain-containing protein 0.0365 0.074 0.074
Echinococcus multilocularis oxysterol binding protein 9 0.0069 0.0099 0.0118
Echinococcus multilocularis epidermal growth factor receptor 0.0056 0.007 0.0083
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Toxoplasma gondii protein kinase domain-containing protein 0.0088 0.0139 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0056 0.007 0.0083
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Loa Loa (eye worm) TK/DDR protein kinase 0.0056 0.007 0.007
Onchocerca volvulus 0.0069 0.0099 0.0544
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.016 0.0295 0.1807
Echinococcus granulosus pleckstrin y domain containing family A 0.0069 0.0099 0.0118
Trypanosoma cruzi NIMA-related kinase, putative 0.0088 0.0139 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0019 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.007 0.0367
Entamoeba histolytica PH domain containing protein kinase, putative 0.0088 0.0139 0.0623
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Leishmania major protein kinase, putative 0.0056 0.007 0.5
Schistosoma mansoni protein tyrosine kinase 0.0056 0.007 0.007
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0056 0.007 0.0367
Echinococcus granulosus semaphorin 1A 0.0365 0.074 0.0884
Trypanosoma brucei protein kinase, putative 0.0088 0.0139 1
Echinococcus granulosus tyrosine kinase 0.0056 0.007 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0099 0.055
Brugia malayi PH domain containing protein 0.0069 0.0099 0.0099
Brugia malayi Immunoglobulin I-set domain containing protein 0.012 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0099
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0069 0.0099 0.0118
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.007 0.0174
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0067 0.008
Entamoeba histolytica protein kinase, putative 0.0056 0.007 0.0176
Brugia malayi hypothetical protein 0.0069 0.0099 0.0099
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0079 0.012 0.0503
Schistosoma mansoni regulator of G protein signaling 0.0753 0.1579 0.1579
Loa Loa (eye worm) TK/RYK protein kinase 0.0056 0.007 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0049 0.0236
Toxoplasma gondii protein kinase domain-containing protein 0.0056 0.007 0.5
Plasmodium falciparum serine/threonine protein kinase, putative 0.0079 0.012 0.8658
Entamoeba histolytica protein kinase, putative 0.0056 0.007 0.0174
Schistosoma mansoni hypothetical protein 0.0365 0.074 0.074
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0099
Plasmodium falciparum protein kinase, putative 0.0056 0.007 0.5
Trypanosoma cruzi protein kinase, putative 0.0056 0.007 0.2828
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0056 0.007 0.0083
Trichomonas vaginalis protein tyrosine kinase, putative 0.0056 0.007 0.0367
Brugia malayi Sema domain containing protein 0.0365 0.074 0.074
Loa Loa (eye worm) protein kinase domain-containing protein 0.0056 0.007 0.007
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.016 0.0295 0.1807
Echinococcus granulosus retinal guanylyl cyclase 2 0.0056 0.007 0.0083
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0069 0.0099 0.0361
Echinococcus multilocularis dynamin 1 0.0069 0.0099 0.0118
Echinococcus granulosus insulin receptor 0.0056 0.007 0.0083
Echinococcus granulosus ephrin type A receptor 4 A 0.0056 0.007 0.0083
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0171 0.032 0.032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0067 0.0346
Echinococcus granulosus fibroblast growth factor receptor 4 0.0056 0.007 0.0083
Entamoeba histolytica hypothetical protein 0.0753 0.1579 1
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0056 0.007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.016 0.0295 0.1807
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0056 0.007 0.0083
Echinococcus granulosus activated cdc42 kinase 1 0.0056 0.007 0.0083
Brugia malayi Variant SH3 domain containing protein 0.0069 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.0056 0.007 0.007
Loa Loa (eye worm) TK/EPH protein kinase 0.0056 0.007 0.007
Brugia malayi hypothetical protein 0.0365 0.074 0.074
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0069 0.0099 0.0361
Onchocerca volvulus 0.0069 0.0099 0.0544
Plasmodium falciparum protein kinase, putative 0.0074 0.011 0.7918
Echinococcus multilocularis neuroglian 0.0115 0.0199 0.0238
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Echinococcus multilocularis tyrosine protein kinase HCK 0.0056 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0753 0.1579 0.1579
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0088 0.0139 1
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0088 0.0139 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0056 0.007 0.5
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Echinococcus multilocularis kinase suppressor of Ras 1 0.0056 0.007 0.0083
Echinococcus granulosus protein tyrosine kinase 0.0056 0.007 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Giardia lamblia Protein 21.1 0.0056 0.007 0.0606
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.007 0.0174
Brugia malayi Uncoordinated protein 104 0.0069 0.0099 0.0099
Brugia malayi hypothetical protein 0.0029 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0099
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0115 0.0199 0.0199
Schistosoma mansoni dynamin 0.0069 0.0099 0.0099
Entamoeba histolytica PH domain containing protein kinase, putative 0.0088 0.0139 0.0623
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0069 0.0099 0.055
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.007 0.0174
Entamoeba histolytica protein kinase, putative 0.0056 0.007 0.0174
Schistosoma mansoni oxysterol-binding protein 1 0.0069 0.0099 0.0099
Onchocerca volvulus 0.0056 0.007 0.0386
Trypanosoma cruzi aurora B kinase, putative 0.0079 0.012 0.8075
Brugia malayi Regulator of G protein signaling domain containing protein 0.0753 0.1579 0.1579
Echinococcus granulosus tyrosine protein kinase csk 0.0056 0.007 0.0083
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0069 0.0099 0.0361
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0043 0.0052
Entamoeba histolytica serine/threonine kinase, putative 0.0056 0.007 0.0174
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0079 0.012 0.0144
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Loa Loa (eye worm) AUR protein kinase 0.0079 0.012 0.012
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Echinococcus multilocularis oxysterol binding protein 1 0.0069 0.0099 0.0118
Schistosoma mansoni protein kinase 0.0056 0.007 0.007
Toxoplasma gondii protein kinase 0.0056 0.007 0.5
Brugia malayi hypothetical protein 0.012 0.021 0.021
Echinococcus multilocularis calcium dependent secretion activator 1 0.0069 0.0099 0.0118
Entamoeba histolytica protein kinase, putative 0.0056 0.007 0.0174
Echinococcus granulosus tyrosine kinase 0.0056 0.007 0.0083
Echinococcus granulosus tyrosine protein kinase csk 0.0056 0.007 0.0083
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0069 0.0099 0.0118
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0069 0.0099 0.0099
Onchocerca volvulus outspread protein homolog 0.0069 0.0099 0.0544
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Onchocerca volvulus 0.0056 0.007 0.0386
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0056 0.007 0.007
Brugia malayi C-terminal src kinase protein 1 0.0056 0.007 0.007
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.007 0.0174
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0067 0.2489
Trypanosoma brucei PH domain containing protein, putative 0.0069 0.0099 0.6999
Schistosoma mansoni protein kinase 0.0074 0.011 0.011
Onchocerca volvulus 0.0056 0.007 0.0386
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0069 0.0099 0.0099
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0069 0.0099 0.0099
Toxoplasma gondii hypothetical protein 0.0069 0.0099 0.7082
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.1754 0.2095
Echinococcus multilocularis Immunoglobulin 0.0115 0.0199 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0099 0.055
Loa Loa (eye worm) TK/ALK protein kinase 0.0298 0.0594 0.0594
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Entamoeba histolytica hypothetical protein 0.0069 0.0099 0.0361
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.007 0.0174
Brugia malayi bone morphogenetic protein type 1 receptor 0.0056 0.007 0.007
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0069 0.0099 0.0361
Brugia malayi PH domain containing protein 0.0069 0.0099 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.016 0.0295 0.1807
Echinococcus multilocularis tyrosine protein kinase csk 0.0056 0.007 0.0083
Echinococcus multilocularis tyrosine kinase 0.0056 0.007 0.0083
Onchocerca volvulus 0.0034 0.0023 0.0124
Entamoeba histolytica protein kinase, putative 0.0088 0.0139 0.0623
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.007 0.007
Loa Loa (eye worm) Plekhf2 protein 0.0069 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.012 0.021 0.021
Loa Loa (eye worm) TK protein kinase 0.0056 0.007 0.007
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0069 0.0099 0.0118
Schistosoma mansoni rho gtpase activating protein 0.0069 0.0099 0.0099
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Echinococcus multilocularis Pleckstrin y 0.0069 0.0099 0.0118
Loa Loa (eye worm) hypothetical protein 0.0115 0.0199 0.0199
Echinococcus multilocularis GRB2 associated binding protein 3 0.0069 0.0099 0.0118
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0069 0.0099 0.055
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Echinococcus multilocularis insulin receptor 0.0056 0.007 0.0083
Echinococcus multilocularis tyrosine protein kinase Abl 0.0056 0.007 0.0083
Echinococcus multilocularis tyrosine protein kinase shark 0.0056 0.007 0.0083
Echinococcus granulosus kinase suppressor of Ras 1 0.0056 0.007 0.0083
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.007 0.0174
Loa Loa (eye worm) hypothetical protein 0.0029 0.0012 0.0012
Echinococcus multilocularis DCC interacting protein 13 beta 0.0069 0.0099 0.0118
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.007 0.0174
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.007 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Echinococcus multilocularis cytohesin 1 0.0069 0.0099 0.0118
Loa Loa (eye worm) hypothetical protein 0.016 0.0295 0.0295
Schistosoma mansoni oxysterol-binding protein 1 0.0069 0.0099 0.0099
Trichomonas vaginalis centaurin/arf, putative 0.0069 0.0099 0.055
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.3889 0.837 0.837
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0024 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.007 0.0367
Leishmania major protein kinase, putative 0.0079 0.012 0.8658
Echinococcus multilocularis Pleckstrin y 0.0069 0.0099 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0099 0.055
Onchocerca volvulus 0.0069 0.0099 0.0544
Echinococcus granulosus epidermal growth factor receptor 0.0056 0.007 0.0083
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0056 0.007 0.0083
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Trypanosoma cruzi PH domain containing protein, putative 0.0069 0.0099 0.5814
Loa Loa (eye worm) serine/threonine protein kinase 0.0056 0.007 0.007
Entamoeba histolytica cell surface protease gp63, putative 0.016 0.0295 0.1643
Loa Loa (eye worm) hypothetical protein 0.0115 0.0199 0.0199
Echinococcus multilocularis regulator of G protein signaling 7 0.0753 0.1579 0.1886
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0056 0.007 0.0386
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0056 0.007 0.0083
Toxoplasma gondii aurora kinase 0.0079 0.012 0.8658
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0365 0.074 0.074
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0056 0.007 0.0083
Leishmania major folate/biopterin transporter, putative 0.0088 0.0139 1
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.007 0.0174
Echinococcus multilocularis tyrosine protein kinase csk 0.0056 0.007 0.0083
Echinococcus multilocularis transfer RNA-Thr 0.0056 0.007 0.0083
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Echinococcus multilocularis epidermal growth factor receptor 0.0056 0.007 0.0083
Entamoeba histolytica protein kinase, putative 0.0056 0.007 0.0174
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0067 0.4764
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0088 0.0139 1
Schistosoma mansoni myotubularin-related protein 0.0069 0.0099 0.0099
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Schistosoma mansoni fibrocystin l 0.016 0.0295 0.0295
Echinococcus multilocularis activin receptor type 0.0074 0.011 0.0132
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0069 0.0099 0.0361
Entamoeba histolytica protein kinase domain containing protein 0.0079 0.012 0.0503
Brugia malayi PH domain containing protein 0.0069 0.0099 0.0099
Brugia malayi PH domain containing protein 0.0069 0.0099 0.0099
Echinococcus multilocularis axis inhibition protein axin 0.0753 0.1579 0.1886
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.007 0.0174
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Echinococcus multilocularis regulator of G protein signaling 3 0.0753 0.1579 0.1886
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.007 0.0174
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.1754 0.1754
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0074 0.011 0.7918
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0088 0.0139 0.0807
Entamoeba histolytica protein kinase, putative 0.0056 0.007 0.0174
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0067 0.0067
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0074 0.011 0.7859
Echinococcus granulosus exocyst complex component 2 0.016 0.0295 0.0353
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0056 0.007 0.0083
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0753 0.1579 0.1579
Echinococcus multilocularis semaphorin 5B 0.0365 0.074 0.0884
Schistosoma mansoni hypothetical protein 0.0069 0.0099 0.0099
Schistosoma mansoni semaphorin 5-related 0.0365 0.074 0.074
Loa Loa (eye worm) hypothetical protein 0.0495 0.1021 0.1021
Schistosoma mansoni serine/threonine protein kinase 0.3558 0.7653 0.7653
Onchocerca volvulus 0.0056 0.007 0.0386
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0036 0.2583
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0099 0.055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0067 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.007 0.0367
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0056 0.007 0.007
Entamoeba histolytica receptor protein kinase, putative 0.0056 0.007 0.0174
Loa Loa (eye worm) hypothetical protein 0.0056 0.007 0.007
Echinococcus granulosus tyrosine protein kinase Src42A 0.0056 0.007 0.0083
Schistosoma mansoni nephrin 0.012 0.021 0.021
Plasmodium falciparum PH domain-containing protein, putative 0.0069 0.0099 0.7082
Trichomonas vaginalis centaurin alpha, putative 0.0069 0.0099 0.055
Echinococcus granulosus Immunoglobulin 0.0115 0.0199 0.0238
Echinococcus granulosus cGMP dependent protein kinase 0.0024 0.0001 0.0001
Echinococcus multilocularis beta 1 syntrophin 0.0069 0.0099 0.0118
Trypanosoma brucei rac serine-threonine kinase, putative 0.0088 0.0139 1
Echinococcus granulosus tyrosine kinase 0.0056 0.007 0.0083
Schistosoma mansoni serine/threonine protein kinase 0.3558 0.7653 0.7653
Entamoeba histolytica protein kinase, putative 0.0056 0.007 0.0174
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0056 0.007 0.0083
Entamoeba histolytica protein kinase, putative 0.0088 0.0139 0.0623
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0069 0.0099 0.5814
Entamoeba histolytica hypothetical protein 0.0088 0.0139 0.0623
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.007 0.0174
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0056 0.007 0.0367
Loa Loa (eye worm) TK protein kinase 0.0056 0.007 0.007
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.007 0.0083
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0056 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0056 0.007 0.007
Echinococcus granulosus microtubule associated protein 2 0.0833 0.1754 0.2095
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0139 0.0807
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.007 0.0174
Trichomonas vaginalis AGC family protein kinase 0.0079 0.012 0.0689
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Loa Loa (eye worm) TK/ROR protein kinase 0.0056 0.007 0.007
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.007 0.0174
Echinococcus multilocularis exocyst complex component 2 0.016 0.0295 0.0353
Echinococcus multilocularis heat shock protein 70 0.0056 0.007 0.0083
Schistosoma mansoni syntrophin 0.0069 0.0099 0.0099
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.007 0.0174
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0069 0.0099 0.0099
Echinococcus multilocularis regulator of G protein signaling 7 0.0753 0.1579 0.1886
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0088 0.0139 1
Echinococcus multilocularis protein kinase 0.0056 0.007 0.0083
Brugia malayi hypothetical protein 0.0056 0.007 0.007
Trypanosoma brucei Flagellum attachment zone protein 20 0.0056 0.007 0.4858
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.007 0.0367
Echinococcus granulosus Regulator of G protein signaling 20 0.0753 0.1579 0.1886
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0056 0.007 0.007
Schistosoma mansoni zinc finger protein 0.0069 0.0099 0.0099
Schistosoma mansoni goodpasture antigen-binding protein 0.0069 0.0099 0.0099
Echinococcus granulosus tyrosine protein kinase HCK 0.0056 0.007 0.0083
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.007 0.0174
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0056 0.007 0.0174
Echinococcus multilocularis Pleckstrin y 0.0069 0.0099 0.0118
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Entamoeba histolytica hypothetical protein 0.0056 0.007 0.0174
Entamoeba histolytica tyrosin kinase, putative 0.0216 0.0416 0.2429
Entamoeba histolytica hypothetical protein 0.016 0.0295 0.1643
Echinococcus multilocularis tyrosine protein kinase 0.0056 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0099
Entamoeba histolytica p21-activated kinase 0.0088 0.0139 0.0623
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0099
Brugia malayi regulator of G-protein signaling egl-10 0.0753 0.1579 0.1579
Schistosoma mansoni regulator of G protein signaling 0.0753 0.1579 0.1579
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0069 0.0099 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0056 0.007 0.0367
Schistosoma mansoni vav2 0.0069 0.0099 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.007 0.0367
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Entamoeba histolytica tyrosine kinase, putative 0.0056 0.007 0.0174
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0044 0.0044
Toxoplasma gondii phosphatidylinositol transfer protein 0.0069 0.0099 0.7082
Brugia malayi Plekhf2 protein 0.0069 0.0099 0.0099
Trichomonas vaginalis AGC family protein kinase 0.0079 0.012 0.0689
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0056 0.007 0.0083
Echinococcus multilocularis Oxysterol binding protein 11 0.0069 0.0099 0.0118
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Plasmodium falciparum tyrosine kinase-like protein 0.0056 0.007 0.5
Trichomonas vaginalis TK family protein kinase 0.0056 0.007 0.0367
Loa Loa (eye worm) hypothetical protein 0.0056 0.007 0.007
Brugia malayi Protein kinase domain containing protein 0.0056 0.007 0.007
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0088 0.0139 1
Entamoeba histolytica protein kinase, putative 0.0088 0.0139 0.0623
Entamoeba histolytica receptor protein kinase, putative 0.0056 0.007 0.0174
Leishmania major hypothetical protein, conserved 0.0056 0.007 0.5
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0365 0.074 0.074
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0074 0.011 0.7014
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0036 0.0036
Brugia malayi Cytohesin 3 0.0069 0.0099 0.0099
Schistosoma mansoni growth factor receptor-bound protein 0.0069 0.0099 0.0099
Loa Loa (eye worm) AGC/PKG protein kinase 0.0024 0.0001 0.0001
Echinococcus multilocularis plexin a4 0.102 0.2158 0.2578
Brugia malayi Protein kinase domain containing protein 0.0298 0.0594 0.0594
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0079 0.012 0.7316
Brugia malayi plexin A 0.102 0.2158 0.2158
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.007 0.0083
Echinococcus granulosus axis inhibition protein axin 0.0753 0.1579 0.1886
Entamoeba histolytica protein kinase, putative 0.0056 0.007 0.0174
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0056 0.007 0.007
Schistosoma mansoni tyrosine kinase 0.0056 0.007 0.007
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0069 0.0099 0.0361
Schistosoma mansoni protein kinase 0.0056 0.007 0.007
Schistosoma mansoni protein kinase 0.0074 0.011 0.011
Entamoeba histolytica PH domain containing protein kinase, putative 0.0088 0.0139 0.0623
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0088 0.0139 1
Brugia malayi PH domain containing protein 0.0069 0.0099 0.0099
Giardia lamblia Aurora kinase 0.0079 0.012 1
Loa Loa (eye worm) hypothetical protein 0.0753 0.1579 0.1579
Entamoeba histolytica hypothetical protein 0.0069 0.0099 0.0361
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0069 0.0099 0.0099
Echinococcus granulosus expressed protein 0.0753 0.1579 0.1886

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 0.631 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 3.2643 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 3.6898 uM PubChem BioAssay. Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in WT MEF Cells: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 9.2683 uM PUBCHEM_BIOASSAY: IN Cell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID493208] ChEMBL. No reference
Potency (functional) 10.3992 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 26.1216 uM PubChem BioAssay. InCell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in WT MEF Cells: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.1216 uM PubChem BioAssay. InCell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.