Detailed information for compound 143822

Basic information

Technical information
  • TDR Targets ID: 143822
  • Name: 2-(2,5-dimethoxyphenyl)morpholine
  • MW: 223.268 | Formula: C12H17NO3
  • H donors: 1 H acceptors: 0 LogP: 0.89 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1C1CNCCO1)OC
  • InChi: 1S/C12H17NO3/c1-14-9-3-4-11(15-2)10(7-9)12-8-13-5-6-16-12/h3-4,7,12-13H,5-6,8H2,1-2H3
  • InChiKey: ZSSXDMNVMKGEBE-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0003 0.0009
Mycobacterium tuberculosis Probable lipase LipE 0.0257 0.0279 0.0278
Echinococcus multilocularis Niemann Pick C1 protein 0.0305 0.0335 0.1095
Echinococcus multilocularis beta LACTamase domain containing family member 0.0257 0.0279 0.0911
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0038 0.0242
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.0035 0.0115
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0002 0.0001
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.0279 0.8615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0003 0.0125
Echinococcus granulosus geminin 0.0877 0.1014 0.6489
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.0035 0.0115
Trichomonas vaginalis chromobox protein, putative 0.007 0.0056 0.2014
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0006 0.02
Mycobacterium tuberculosis Conserved protein 0.0257 0.0279 0.0278
Schistosoma mansoni hypothetical protein 0.0171 0.0177 0.1133
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0147 0.0481
Schistosoma mansoni smad 0.005 0.0033 0.0211
Brugia malayi follicle stimulating hormone receptor 0.0227 0.0243 0.2887
Schistosoma mansoni hypothetical protein 0.0079 0.0068 0.0434
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Brugia malayi MAP kinase sur-1 0.0054 0.0038 0.0448
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0217 0.0231 0.1477
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0139 0.0887
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0052 0.0035 0.0417
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0038 0.1166
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0003 0.0022
Loa Loa (eye worm) hypothetical protein 0.03 0.033 0.3917
Mycobacterium tuberculosis Probable lipase LipD 0.0257 0.0279 0.0278
Entamoeba histolytica cysteine proteinase 2 0.0025 0.0004 0.0134
Onchocerca volvulus 0.0084 0.0073 0.2217
Onchocerca volvulus 0.0033 0.0013 0.0384
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0073 0.087
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.002 0.0627
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0139 0.4305
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Trypanosoma cruzi major cysteine proteinase, putative 0.0148 0.0149 0.4594
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0039 0.046
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.014 0.0895
Trichomonas vaginalis penicillin-binding protein, putative 0.0257 0.0279 1
Brugia malayi Inositol-1 0.0039 0.0019 0.0231
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0068 0.0222
Loa Loa (eye worm) glutamate receptor 0.0035 0.0015 0.0176
Echinococcus granulosus cathepsin L 0.0025 0.0004 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0147 0.0943
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0257 0.0279 0.0278
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0006 0.0073
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.0266 0.1705
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0038 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0006 0.0231
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0003 0.0017
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.0199 0.1273
Trypanosoma brucei protein kinase, putative 0.0054 0.0038 0.1166
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0035 0.0015 0.0097
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0006 0.068
Entamoeba histolytica hypothetical protein 0.0025 0.0003 0.0122
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0023 0.0709
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0032 0.1124
Trypanosoma cruzi cysteine peptidase, putative 0.0049 0.0032 0.0994
Brugia malayi MH1 domain containing protein 0.0028 0.0006 0.0077
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0257 0.0279 0.0278
Brugia malayi MH2 domain containing protein 0.005 0.0033 0.0391
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2604 0.3061 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0068 0.0805
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.0035 0.0417
Brugia malayi chromobox protein homolog 3 0.0039 0.002 0.0237
Schistosoma mansoni survival motor neuron protein 0.005 0.0033 0.0214
Schistosoma mansoni ferritin 0.0052 0.0035 0.0224
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0073 0.0469
Loa Loa (eye worm) hypothetical protein 0.0033 0.0013 0.0153
Plasmodium vivax unspecified product 0.0025 0.0004 0.0138
Loa Loa (eye worm) DR-78 0.0024 0.0003 0.0032
Trypanosoma cruzi cysteine peptidase, putative 0.0188 0.0196 0.6066
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0013 0.0082
Schistosoma mansoni hypothetical protein 0.0877 0.1014 0.6489
Onchocerca volvulus 0.0049 0.0032 0.097
Onchocerca volvulus 0.0024 0.0003 0.0076
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0023 0.0809
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Brugia malayi hypothetical protein 0.0028 0.0006 0.0077
Brugia malayi Receptor family ligand binding region containing protein 0.0023 0.0001 0.0006
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0003 0.0076
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0031 0.0198
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0003 0.0017
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0263 0.0286 0.0935
Trypanosoma cruzi cysteine peptidase, putative 0.0188 0.0196 0.6066
Loa Loa (eye worm) hypothetical protein 0.0257 0.0279 0.3311
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0049 0.0032 0.4723
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0031 0.0198
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0147 0.0943
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0019 0.0019
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0031 0.0101
Loa Loa (eye worm) hypothetical protein 0.0049 0.0032 0.0382
Echinococcus multilocularis ferritin 0.0052 0.0035 0.0114
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0147 0.0943
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0003 0.0009
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.0035 0.0115
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0052 0.0035 0.0034
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0112
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0038 0.0242
Entamoeba histolytica cysteine protease, putative 0.0049 0.0032 0.1124
Brugia malayi tailless protein 0.0024 0.0003 0.0032
Onchocerca volvulus 0.0148 0.0149 0.4516
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1644 0.1923 0.1923
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.002 0.0627
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0003 0.0096
Schistosoma mansoni hypothetical protein 0.0088 0.0078 0.0502
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0001 0.0011
Mycobacterium ulcerans transcriptional regulator 0.8456 1 1
Plasmodium vivax vivapain-2 0.0049 0.0032 0.1154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0006 0.018
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.0199 0.0649
Schistosoma mansoni hypothetical protein 0.0263 0.0286 0.1832
Loa Loa (eye worm) hypothetical protein 0.0247 0.0266 0.3162
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0052 0.0035 0.0115
Brugia malayi nuclear hormone receptor 0.0052 0.0035 0.0417
Echinococcus multilocularis Smad4 0.005 0.0033 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.002 0.0627
Trypanosoma cruzi cysteine proteinase, putative 0.0025 0.0004 0.0119
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0035 0.0015 0.0466
Onchocerca volvulus 0.0031 0.001 0.0296
Schistosoma mansoni intermediate filament proteins 0.03 0.033 0.2112
Echinococcus granulosus TGF beta signal transducer SmadC 0.005 0.0033 0.0211
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Brugia malayi Cathepsin L-like precursor 0.0049 0.0032 0.0382
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0001 0.0032
Echinococcus granulosus importin subunit beta 1 0.003 0.0009 0.006
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0034 0.1041
Toxoplasma gondii cathepsin CPL 0.0049 0.0032 0.1154
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0257 0.0279 0.0278
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0044 0.0284
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0251 0.0271 0.3219
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0321 0.0355 0.421
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0006 0.02
Echinococcus granulosus dna polymerase kappa 0.0039 0.002 0.013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0147 0.0481
Echinococcus multilocularis thyroid hormone receptor alpha 0.0303 0.0333 0.1088
Loa Loa (eye worm) hypothetical protein 0.0052 0.0035 0.0417
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0257 0.0279 0.3311
Loa Loa (eye worm) ctsf protein 0.0049 0.0032 0.0382
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0035 0.0417
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0257 0.0279 0.1785
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0039 0.0248
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0031 0.0198
Schistosoma mansoni smad1 5 8 and 0.005 0.0033 0.0211
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0038 0.0242
Loa Loa (eye worm) hypothetical protein 0.0022 0 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.002 0.0627
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0003 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.002 0.0715
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.0035 0.0115
Echinococcus granulosus expressed protein 0.0052 0.0035 0.0224
Entamoeba histolytica cysteine proteinase 1, putative 0.0025 0.0004 0.0134
Brugia malayi Cathepsin L-like precursor 0.0049 0.0032 0.0382
Onchocerca volvulus Cathepsin L homolog 0.0049 0.0032 0.097
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0109 0.0102 0.0335
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0023 0.0709
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0006 0.0077
Brugia malayi MH2 domain containing protein 0.0733 0.0842 1
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0013 0.0449
Plasmodium falciparum cysteine proteinase falcipain 1 0.0025 0.0004 0.0564
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0001 0.0011
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0018 0.2715
Loa Loa (eye worm) hypothetical protein 0.0171 0.0177 0.2102
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0015 0.0541
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0031 0.0198
Brugia malayi nuclear receptor RXR 0.0024 0.0003 0.0032
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.0035 0.0225
Echinococcus granulosus cathepsin l1 0.0049 0.0032 0.0206
Entamoeba histolytica hypothetical protein 0.0024 0.0003 0.0093
Plasmodium vivax hypothetical protein, conserved 0.0257 0.0279 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0006 0.0073
Schistosoma mansoni thyroid hormone receptor 0.0303 0.0333 0.2133
Loa Loa (eye worm) isocitrate dehydrogenase 0.0035 0.0015 0.0179
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0044 0.0145
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0044 0.1591
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0015 0.0466
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0003 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0006 0.018
Loa Loa (eye worm) hypothetical protein 0.0039 0.002 0.0241
Echinococcus granulosus Smad4 0.005 0.0033 0.0211
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0068 0.0805
Onchocerca volvulus 0.03 0.033 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.002 0.013
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0004 0.0046
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0003 0.0108
Schistosoma mansoni transcription factor LCR-F1 0.0263 0.0286 0.1832
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0025 0.0004 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0052 0.0035 0.0417
Schistosoma mansoni apoferritin-2 0.0052 0.0035 0.0224
Echinococcus multilocularis cysteine protease 0.0049 0.0032 0.0105
Onchocerca volvulus 0.0257 0.0279 0.8451
Loa Loa (eye worm) hypothetical protein 0.0109 0.0102 0.1216
Brugia malayi Muscleblind-like protein 0.0147 0.0148 0.1751
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0035 0.0115
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0032 0.1154
Brugia malayi RNA recognition motif domain containing protein 0.0139 0.0139 0.1645
Schistosoma mansoni coup transcription factor 0.0052 0.0035 0.0225
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.002 0.0715
Schistosoma mansoni hypothetical protein 0.0088 0.0078 0.0502
Loa Loa (eye worm) hypothetical protein 0.0027 0.0006 0.0073
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0003 0.0017
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0003 0.0076
Loa Loa (eye worm) hypothetical protein 0.0052 0.0035 0.0417
Brugia malayi cathepsin L-like precursor 0.0033 0.0013 0.0153
Brugia malayi hypothetical protein 0.0263 0.0286 0.3396
Mycobacterium ulcerans TetR family transcriptional regulator 0.8456 1 1
Loa Loa (eye worm) hypothetical protein 0.0257 0.0279 0.3311
Brugia malayi Isocitrate dehydrogenase 0.0035 0.0015 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Onchocerca volvulus 0.005 0.0033 0.1008
Echinococcus multilocularis chromobox protein 1 0.007 0.0056 0.0183
Schistosoma mansoni hypothetical protein 0.0079 0.0068 0.0434
Loa Loa (eye worm) hypothetical protein 0.0092 0.0082 0.0977
Loa Loa (eye worm) hypothetical protein 0.0052 0.0035 0.0417
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0139 0.4305
Echinococcus multilocularis geminin 0.0877 0.1014 0.3311
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0073 0.0239
Echinococcus granulosus smad 0.005 0.0033 0.0211
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0031 0.0366
Loa Loa (eye worm) MBCTL1 0.0055 0.0039 0.046
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0006 0.0077
Onchocerca volvulus Protein ultraspiracle homolog 0.0052 0.0035 0.106
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0118
Plasmodium falciparum importin beta, putative 0.003 0.0009 0.1383
Leishmania major importin beta-1 subunit, putative 0.0024 0.0003 0.0083
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Echinococcus granulosus GPCR family 2 0.0079 0.0068 0.0434
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.0324 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Echinococcus multilocularis cysteine protease 0.0049 0.0032 0.0105
Schistosoma mansoni hypothetical protein 0.0877 0.1014 0.6489
Echinococcus multilocularis cathepsin L 0.0025 0.0004 0.0013
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0006 0.0918
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0068 0.0222
Leishmania major cathepsin L-like protease 0.0049 0.0032 0.0994
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0003 0.0017
Loa Loa (eye worm) hypothetical protein 0.0251 0.0271 0.3219
Loa Loa (eye worm) transcription factor SMAD2 0.0733 0.0842 1
Trichomonas vaginalis ferritin, putative 0.0052 0.0035 0.1255
Mycobacterium ulcerans bacterioferritin BfrA 0.0052 0.0035 0.0034
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0036 0.0035
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0043 0.0509
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0019 0.0697
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0004 0.0134
Leishmania major DNA polymerase kappa, putative 0.0039 0.002 0.0627
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0002 0.0054
Trichomonas vaginalis D-aminoacylase, putative 0.0257 0.0279 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0213 0.0227 0.7925
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0031 0.093
Onchocerca volvulus 0.0048 0.0031 0.093
Schistosoma mansoni hypothetical protein 0.0088 0.0078 0.0502
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0002 0.0001
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0044 0.0284
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0023 0.0001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0011
Onchocerca volvulus Huntingtin homolog 0.0124 0.012 0.3646
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.002 0.0709
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0031 0.0198
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0009 0.0291
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.002 0.0019
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0023 0.0809
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0025 0.0004 0.0025
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0032 0.1124
Plasmodium vivax vivapain-1 0.0025 0.0004 0.0138
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.002 0.0019
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0056 0.0667
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0044 0.0043
Echinococcus multilocularis expressed protein 0.0052 0.0035 0.0114
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0006 0.004
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0052 0.0035 0.0417
Trypanosoma cruzi cysteine proteinase, putative 0.0025 0.0004 0.0119
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0009 0.0291
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0052 0.0035 0.0417
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.002 0.013
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0035 0.0225
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0003 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0035 0.0417
Echinococcus granulosus lamin 0.03 0.033 0.2112
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0033 0.0397
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0036 0.0035
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.002 0.0627
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.0324 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0092 0.0082 0.0269
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0015 0.0014
Brugia malayi Cathepsin L-like precursor 0.0049 0.0032 0.0382
Schistosoma mansoni cathepsin F (C01 family) 0.0049 0.0032 0.0206
Loa Loa (eye worm) hypothetical protein 0.0213 0.0227 0.2692
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0003 0.0009
Onchocerca volvulus 0.0257 0.0279 0.8451
Trichomonas vaginalis D-aminoacylase, putative 0.0257 0.0279 1
Schistosoma mansoni hypothetical protein 0.0251 0.0272 0.1739
Mycobacterium ulcerans lipase LipD 0.0257 0.0279 0.0278
Schistosoma mansoni ferritin 0.0052 0.0035 0.0224
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0002 0.0062
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0019 0.0124
Echinococcus granulosus dna polymerase eta 0.0039 0.002 0.013
Brugia malayi mbt repeat family protein 0.0048 0.0031 0.0366
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0003 0.0083
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0006 0.0949
Loa Loa (eye worm) steroid hormone receptor 0.0052 0.0035 0.0417
Loa Loa (eye worm) hypothetical protein 0.0052 0.0035 0.0417
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0015 0.0049
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.0324 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0035 0.0417
Onchocerca volvulus 0.0023 0.0001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0039 0.002 0.0237
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0018 0.0646
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0025 0.0004 0.0025
Loa Loa (eye worm) hypothetical protein 0.0052 0.0035 0.0417
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0019 0.0601
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.8456 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0003 0.0032
Echinococcus multilocularis cathepsin L cysteine protease 0.0049 0.0032 0.0105
Loa Loa (eye worm) hypothetical protein 0.0257 0.0279 0.3311
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0139 0.0887
Brugia malayi Importin beta-1 subunit 0.003 0.0009 0.0112
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.0035 0.0225
Treponema pallidum bacterioferrin (TpF1) 0.0052 0.0035 0.5012
Trypanosoma cruzi cruzipain precursor, putative 0.0188 0.0196 0.6066
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0035 0.0225
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0004 0.0134
Brugia malayi RNA, U transporter 1 0.0086 0.0075 0.0893
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0002 0.0062
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0038 0.1166
Brugia malayi Heterochromatin protein 1 0.007 0.0056 0.0667
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0251 0.0272 0.0888
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0003 0.0017
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0068 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.002 0.0627
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Echinococcus granulosus Niemann Pick C1 protein 0.0305 0.0335 0.2147
Schistosoma mansoni chromobox protein 0.007 0.0056 0.036
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0068 1
Brugia malayi Cathepsin L-like precursor 0.0049 0.0032 0.0382
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0139 0.0887
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0032 0.1154
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0003 0.0032
Brugia malayi mothers against decapentaplegic homolog 3 0.0022 0 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Leishmania major cytochrome p450-like protein 0.0028 0.0006 0.02
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.002 0.0066
Brugia malayi CHE-14 protein 0.0092 0.0082 0.0977
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0035 0.0015 0.0541
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0015 0.0466
Schistosoma mansoni lamin 0.03 0.033 0.2112
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0038 0.1354
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0049 0.0032 0.0105
Echinococcus multilocularis microtubule associated protein 2 0.1339 0.1562 0.5103
Echinococcus multilocularis protein patched 0.0092 0.0082 0.0269
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0002 0.0001
Trypanosoma cruzi cysteine protease, putative 0.0025 0.0004 0.0119
Echinococcus multilocularis GPCR, family 2 0.0079 0.0068 0.0222
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0023 0.0144
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0006 0.004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0251 0.0271 0.3219
Brugia malayi mbt repeat family protein 0.0048 0.0031 0.0366
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.014 0.0457
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0148 0.0482
Schistosoma mansoni Smad4 0.0022 0 0.0001
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0068 0.2443
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.0035 0.0417
Onchocerca volvulus Cathepsin F homolog 0.0049 0.0032 0.097
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0038 0.0448
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0161 0.0165 0.1954
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0279 0.8615
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0004 0.0046
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0068 0.0067
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0003 0.0032
Echinococcus multilocularis protein dispatched 1 0.0105 0.0098 0.0319
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0006 0.0232
Loa Loa (eye worm) intermediate filament protein 0.03 0.033 0.3917
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Mycobacterium ulcerans hypothetical protein 0.0257 0.0279 0.0278
Echinococcus granulosus beta LACTamase domain containing family member 0.0257 0.0279 0.1785
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.002 0.0627
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0146 0.0147 0.1748
Onchocerca volvulus 0.0049 0.0032 0.097
Echinococcus multilocularis mothers against decapentaplegic 6 0.0022 0 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0013 0.0461
Mycobacterium leprae conserved hypothetical protein 0.0257 0.0279 0.0278
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0011
Loa Loa (eye worm) MH2 domain-containing protein 0.0733 0.0842 1
Echinococcus granulosus microtubule associated protein 2 0.1339 0.1562 1
Mycobacterium tuberculosis Probable esterase LipL 0.0257 0.0279 0.0278
Brugia malayi Calcitonin receptor-like protein seb-1 0.0251 0.0271 0.3219
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.03 0.033 0.3917
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Mycobacterium ulcerans bacterioferritin BfrB 0.0052 0.0035 0.0034
Schistosoma mansoni ferritin light chain 0.0052 0.0035 0.0224
Brugia malayi Niemann-Pick C1 protein precursor 0.0213 0.0227 0.2692
Loa Loa (eye worm) nuclear factor I 0.0028 0.0006 0.0077
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0019 0.0601
Echinococcus multilocularis lamin 0.03 0.033 0.1078
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0068 0.0436
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0039 0.0248
Echinococcus granulosus sterol regulatory element binding protein 0.0092 0.0082 0.0527
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.014 0.1659
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0044 0.0043
Echinococcus multilocularis cathepsin L cysteine protease 0.0049 0.0032 0.0105
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0003 0.0032
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0002 0.0001
Echinococcus granulosus expressed conserved protein 0.02 0.0211 0.1353
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.002 0.0241
Brugia malayi intermediate filament protein 0.03 0.033 0.3917
Trichomonas vaginalis esterase, putative 0.0257 0.0279 1
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.0266 0.087
Loa Loa (eye worm) glutamate receptor 0.0088 0.0078 0.0929
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0006 0.0006
Mycobacterium tuberculosis Conserved protein 0.0257 0.0279 0.0278
Brugia malayi Cytochrome P450 family protein 0.0028 0.0006 0.0077
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0035 0.0015 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0004 0.0119
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0032 0.1154
Echinococcus granulosus chromobox protein 1 0.007 0.0056 0.036
Entamoeba histolytica hypothetical protein 0.0263 0.0286 1
Echinococcus multilocularis lamin dm0 0.03 0.033 0.1078
Echinococcus multilocularis Niemann Pick C1 protein 0.0213 0.0227 0.0741
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0052 0.0035 0.106
Brugia malayi Probable ClpP-like protease 0.008 0.0068 0.0809
Loa Loa (eye worm) MH1 domain-containing protein 0.0022 0 0.0002
Loa Loa (eye worm) inositol-1 0.0039 0.0019 0.0231
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0032 0.1154
Echinococcus granulosus FTZ F1 alpha 0.0052 0.0035 0.0225
Entamoeba histolytica hypothetical protein 0.0263 0.0286 1
Brugia malayi hypothetical protein 0.0027 0.0006 0.0073
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0052 0.0035 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.0035 0.0417
Mycobacterium tuberculosis Probable hydrolase 0.0257 0.0279 0.0278
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0038 0.1166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0039 0.0127
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0068 0.2443
Brugia malayi nuclear receptor NHR-88 0.0024 0.0003 0.0032
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0039 0.0248
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0035 0.0417
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.002 0.0627
Brugia malayi Cytochrome P450 family protein 0.0028 0.0006 0.0077
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0039 0.0127
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0049 0.0032 0.0382
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0001 0.0032
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0002 0.0054
Brugia malayi MH1 domain containing protein 0.005 0.0033 0.0391
Loa Loa (eye worm) hypothetical protein 0.008 0.0068 0.0809
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0004 0.0134
Loa Loa (eye worm) hypothetical protein 0.0147 0.0148 0.1751
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.0035 0.0115
Echinococcus multilocularis tar DNA binding protein 0.0139 0.0139 0.0453
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0139 0.0887
Leishmania major cathepsin L-like protease 0.0049 0.0032 0.0994
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0068 1
Loa Loa (eye worm) Smad1 0.005 0.0033 0.0391
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0052 0.0035 0.0225
Schistosoma mansoni DNA polymerase eta 0.0039 0.002 0.013
Schistosoma mansoni smad1 5 8 and 0.005 0.0033 0.0211
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0049 0.0032 0.1154
Onchocerca volvulus 0.0052 0.0035 0.106
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0068 0.0805
Echinococcus multilocularis TGF beta signal transducer SmadC 0.005 0.0033 0.0108
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0139 0.0887
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.002 0.0627
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.0035 0.0225
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.002 0.0627
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0035 0.0417
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 0.0243 0.2887
Schistosoma mansoni hypothetical protein 0.0079 0.0068 0.0434
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.002 0.0627
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.0035 0.0225
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0145 0.0146 0.0476
Echinococcus multilocularis musashi 0.03 0.033 0.1078
Schistosoma mansoni hypothetical protein 0.005 0.0033 0.0214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Loa Loa (eye worm) hypothetical protein 0.0027 0.0006 0.0073
Echinococcus multilocularis muscleblind protein 0.0147 0.0148 0.0482
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0147 0.0148 0.1751
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0004 0.0119
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.002 0.0627
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0038 0.0123
Loa Loa (eye worm) hypothetical protein 0.0033 0.0013 0.0153
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0052 0.0035 0.5012
Echinococcus granulosus metabotropic glutamate receptor 5 0.0109 0.0102 0.0656
Echinococcus multilocularis mothers against decapentaplegic 5 0.005 0.0033 0.0108
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.008 0.0068 0.0812
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0006 0.002
Echinococcus granulosus mothers against decapentaplegic 6 0.0022 0 0.0001
Echinococcus multilocularis smad 0.005 0.0033 0.0108
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0035 0.0015 0.2214
Brugia malayi beta-lactamase 0.0257 0.0279 0.3311
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.0035 0.0225
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0015 0.0466
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0003 0.0125
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0038 0.1354
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.0035 0.0225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0052 0.0035 0.0417
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0015 0.0049
Brugia malayi nuclear receptor NHR-88 0.0052 0.0035 0.0417
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.002 0.0627
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.002 0.0241
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0044 0.0284
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0158 0.0157
Loa Loa (eye worm) MH2 domain-containing protein 0.005 0.0033 0.0391
Schistosoma mansoni inositol monophosphatase 0.0039 0.0019 0.0124
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0147 0.0943
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Schistosoma mansoni nuclear receptor 0.0024 0.0003 0.0017
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0077
Echinococcus granulosus intermediate filament protein 0.03 0.033 0.2112
Brugia malayi beta-lactamase family protein 0.0257 0.0279 0.3311
Loa Loa (eye worm) TAR-binding protein 0.0139 0.0139 0.1645
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0003 0.0017
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0006 0.02
Plasmodium vivax importin-beta 2, putative 0.003 0.0009 0.0338
Schistosoma mansoni nuclear receptor 0.0024 0.0003 0.0017
Echinococcus multilocularis expressed conserved protein 0.02 0.0211 0.0691
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.0035 0.0225
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0003 0.0041
Brugia malayi steroid hormone receptor 0.0052 0.0035 0.0417
Schistosoma mansoni smad1 5 8 and 0.005 0.0033 0.0211
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0003 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.002 0.0627
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0035 0.0115
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0038 0.1354
Loa Loa (eye worm) hypothetical protein 0.0052 0.0035 0.0417
Trypanosoma brucei unspecified product 0.0027 0.0006 0.018
Brugia malayi Metabotropic glutamate receptor precursor. 0.0088 0.0078 0.0929
Loa Loa (eye worm) MH1 domain-containing protein 0.005 0.0033 0.0391
Leishmania major cathepsin L-like protease 0.0049 0.0032 0.0994
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0023 0.0841
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0036 0.0035
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0001 0.0029
Brugia malayi MH1 domain containing protein 0.005 0.0033 0.0391
Entamoeba histolytica hypothetical protein 0.0024 0.0002 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.002 0.0627
Loa Loa (eye worm) hypothetical protein 0.0027 0.0006 0.0073
Echinococcus granulosus tumor protein p63 0.1011 0.1172 0.7503
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0035 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0035 0.0417
Leishmania major cathepsin L-like protease 0.0188 0.0196 0.6066
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0049 0.0032 0.1154
Echinococcus multilocularis mothers against decapentaplegic 2 0.0022 0 0.0001
Echinococcus granulosus chromobox protein 1 0.007 0.0056 0.036
Echinococcus multilocularis isocitrate dehydrogenase 0.0035 0.0015 0.0049
Brugia malayi cytoplasmic intermediate filament protein 0.0161 0.0165 0.1954
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0002 0.0255
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0025 0.0004 0.0025
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0019 0.2667
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0049 0.0032 0.4723
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0001 0.0029
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.002 0.0727
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0251 0.0272 0.1739
Giardia lamblia DINP protein human, muc B family 0.0039 0.002 0.5373
Loa Loa (eye worm) hypothetical protein 0.0124 0.012 0.143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Loa Loa (eye worm) hypothetical protein 0.0112 0.0107 0.1267
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0003 0.0017
Brugia malayi conserved hypotetical protein 0.0024 0.0003 0.0032
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.002 0.0627
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0068 0.0223
Schistosoma mansoni importin beta-1 0.003 0.0009 0.006
Echinococcus multilocularis snurportin 1 0.0321 0.0355 0.1159
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.002 0.013
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Echinococcus granulosus lamin dm0 0.03 0.033 0.2112
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.0035 0.0225
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Brugia malayi nuclear receptor RXR 0.0027 0.0006 0.0073
Echinococcus multilocularis dna polymerase kappa 0.0039 0.002 0.0066
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.002 0.0627
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0038 0.1166
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Mycobacterium ulcerans hypothetical protein 0.0155 0.0158 0.0157
Loa Loa (eye worm) acetyltransferase 0.014 0.014 0.1659
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0068 0.0434
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.0035 0.0225
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0035 0.0015 0.0049
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0038 0.0123
Schistosoma mansoni ferritin 0.0052 0.0035 0.0224
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0068 0.2443
Echinococcus granulosus cathepsin l cysteine peptidase 0.0049 0.0032 0.0206
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0003 0.0108
Loa Loa (eye worm) hypothetical protein 0.0148 0.0149 0.177
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0015 0.0049
Trypanosoma brucei unspecified product 0.0027 0.0006 0.018
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0006
Mycobacterium tuberculosis Conserved protein 0.0257 0.0279 0.0278
Plasmodium falciparum cysteine proteinase falcipain 3 0.0049 0.0032 0.4723
Loa Loa (eye worm) hypothetical protein 0.0257 0.0279 0.3311
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0023 0.0001 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Leishmania major cathepsin L-like protease 0.0049 0.0032 0.0994
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.002 0.0627
Brugia malayi hypothetical protein 0.0027 0.0006 0.0073
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0068 1
Trichomonas vaginalis chromobox protein, putative 0.007 0.0056 0.2014
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0003 0.0009
Schistosoma mansoni thyroid hormone receptor 0.0303 0.0333 0.2133
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0004 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0004 0.0138
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0001 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0013 0.0461
Onchocerca volvulus Cathepsin L homolog 0.0049 0.0032 0.097
Schistosoma mansoni apoferritin-2 0.0052 0.0035 0.0224
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0038 0.1354
Loa Loa (eye worm) hypothetical protein 0.0295 0.0323 0.384
Leishmania major cysteine peptidase A (CPA) 0.0049 0.0032 0.0994
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Loa Loa (eye worm) hypothetical protein 0.0048 0.0031 0.0366
Brugia malayi latrophilin 2 splice variant baaae 0.0171 0.0177 0.2102
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0074 0.0061 0.02
Brugia malayi nuclear hormone receptor 0.0024 0.0003 0.0032
Entamoeba histolytica hypothetical protein 0.0263 0.0286 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.002 0.0019
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0002 0.0062
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Schistosoma mansoni TGF-beta signal transducer Smad2 0.005 0.0033 0.0211
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0092 0.0082 0.0977
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0279 0.8615
Loa Loa (eye worm) hypothetical protein 0.0033 0.0013 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.0035 0.0417
Brugia malayi isocitrate dehydrogenase 0.0035 0.0015 0.0179
Echinococcus granulosus metabotropic glutamate receptor 2 0.0074 0.0061 0.0392
Loa Loa (eye worm) hypothetical protein 0.0079 0.0068 0.0805
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0006 0.018
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0019 0.0064
Echinococcus granulosus mothers against decapentaplegic 2 0.0022 0 0.0001
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0006 0.0077
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0006 0.0949
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.0135 0.0865
Loa Loa (eye worm) RNA binding protein 0.0139 0.0139 0.1645
Loa Loa (eye worm) hypothetical protein 0.0257 0.0279 0.3311
Brugia malayi nuclear receptor NHR-67 0.0024 0.0003 0.0032
Loa Loa (eye worm) fibroinase 0.0049 0.0032 0.0382
Brugia malayi Cytochrome P450 family protein 0.0058 0.0043 0.0509
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0146 0.0147 0.1748
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0044 0.0043
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0006 0.0073
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0019 0.0697
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.002 0.0727
Schistosoma mansoni metabotropic glutamate receptor 0.0043 0.0025 0.0158
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0001 0.0029
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0023 0.0709
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0023 0.0809
Trichomonas vaginalis D-aminoacylase, putative 0.0257 0.0279 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0073 0.0469
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0004 0.0138
Schistosoma mansoni ferritin light chain 0.0052 0.0035 0.0224
Schistosoma mansoni microtubule-associated protein tau 0.1339 0.1562 1
Echinococcus granulosus ferritin 0.0052 0.0035 0.0224
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0006 0.02
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.0035 0.0225
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0023 0.0809
Brugia malayi beta-lactamase family protein 0.0257 0.0279 0.3311
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0006 0.004
Onchocerca volvulus 0.0049 0.0032 0.097
Schistosoma mansoni Smad4 0.0022 0 0.0001
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0003 0.0032
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0038 0.1166
Trypanosoma cruzi cysteine peptidase, putative 0.0188 0.0196 0.6066
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0035 0.0015 0.0097
Echinococcus granulosus cysteine protease 0.0025 0.0004 0.0025
Brugia malayi ecdysteroid receptor 0.0052 0.0035 0.0417
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0139 0.0139 0.1645
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0263 0.0286 0.1832
Brugia malayi MH1 domain containing protein 0.0028 0.0006 0.0077
Entamoeba histolytica hypothetical protein 0.0263 0.0286 1
Brugia malayi hypothetical protein 0.0247 0.0266 0.3162
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0006 0.0073
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0019 0.0697
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0006 0.02
Onchocerca volvulus 0.0049 0.0032 0.097
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.002 0.0627
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0006 0.0232
Echinococcus granulosus muscleblind protein 0.0147 0.0148 0.0944
Loa Loa (eye worm) hypothetical protein 0.0027 0.0006 0.0073
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0003 0.0096
Loa Loa (eye worm) hypothetical protein 0.0257 0.0279 0.3311
Echinococcus granulosus mothers against decapentaplegic 5 0.005 0.0033 0.0211
Toxoplasma gondii hypothetical protein 0.0048 0.003 0.1082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0006 0.02
Onchocerca volvulus Bile acid receptor homolog 0.0052 0.0035 0.106
Brugia malayi MH2 domain containing protein 0.0022 0 0.0002
Echinococcus multilocularis dna polymerase eta 0.0039 0.002 0.0066
Trichomonas vaginalis penicillin-binding protein, putative 0.0257 0.0279 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.0035 0.0417
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0082 0.2952
Brugia malayi hypothetical protein 0.0024 0.0003 0.0032
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0038 0.1166
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0003 0.0017
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.002 0.0627
Plasmodium vivax vivapain-2 0.0049 0.0032 0.1154
Onchocerca volvulus 0.0049 0.0032 0.097
Leishmania major cathepsin L-like protease 0.0049 0.0032 0.0994
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0019 0.0601
Leishmania major hypothetical protein, conserved 0.0257 0.0279 0.8615
Brugia malayi Smad1 0.005 0.0033 0.0391
Brugia malayi metabotropic glutamate receptor type 2 0.0043 0.0025 0.0293
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0257 0.0279 0.1785
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0003 0.0096
Echinococcus granulosus cathepsin L cysteine protease 0.0025 0.0004 0.0025
Schistosoma mansoni chromobox protein 0.007 0.0056 0.036
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0018 0.49
Onchocerca volvulus 0.03 0.033 1
Mycobacterium ulcerans AcrR family transcriptional regulator 0.8456 1 1
Brugia malayi hypothetical protein 0.0124 0.012 0.143
Schistosoma mansoni hypothetical protein 0.0088 0.0078 0.0502
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0038 0.1166
Echinococcus multilocularis chromobox protein 1 0.007 0.0056 0.0183
Schistosoma mansoni hypothetical protein 0.0293 0.0321 0.2055
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0044 0.0043
Brugia malayi Intermediate filament tail domain containing protein 0.03 0.033 0.3917
Onchocerca volvulus 0.0024 0.0003 0.0076
Echinococcus multilocularis tumor protein p63 0.1011 0.1172 0.3828
Schistosoma mansoni Smad4 0.005 0.0033 0.0211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0052 0.0035 0.0417
Mycobacterium ulcerans esterase/lipase LipP 0.0257 0.0279 0.0278
Leishmania major DNA polymerase eta, putative 0.0039 0.002 0.0627
Brugia malayi Cathepsin L-like precursor 0.0049 0.0032 0.0382
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0171 0.0177 0.5469
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0049 0.0032 0.0382
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0003 0.0011
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0003 0.0032
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0032 0.1154
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.0035 0.0225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0032 0.1154
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0035 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Loa Loa (eye worm) hypothetical protein 0.0124 0.012 0.143
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0257 0.0279 0.0278
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0006 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.0035 0.0417
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0015 0.0014
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.0035 0.0225
Echinococcus granulosus Protein patched homolog 1 0.0092 0.0082 0.0527
Schistosoma mansoni inositol monophosphatase 0.0039 0.0019 0.0124
Trypanosoma brucei unspecified product 0.0039 0.002 0.0627
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.0324 1
Schistosoma mansoni patched 1 0.0092 0.0082 0.0527
Schistosoma mansoni cellular tumor antigen P53 0.0148 0.0149 0.0955
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0019 0.0697
Echinococcus granulosus Niemann Pick C1 protein 0.0213 0.0227 0.1452
Schistosoma mansoni ferritin 0.0052 0.0035 0.0224
Loa Loa (eye worm) hypothetical protein 0.0139 0.0139 0.1652
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0023 0.0841
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0068 0.0067
Toxoplasma gondii hypothetical protein 0.0027 0.0006 0.0224
Onchocerca volvulus 0.0049 0.0032 0.097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Brugia malayi Cathepsin L-like cysteine proteinase 0.0033 0.0013 0.0153
Schistosoma mansoni hypothetical protein 0.0079 0.0068 0.0434
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0019 0.0601
Onchocerca volvulus Huntingtin homolog 0.0124 0.012 0.3646
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Toxoplasma gondii ABC1 family protein 0.0257 0.0279 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0049 0.0032 0.0206
Leishmania major cathepsin L-like protease 0.0188 0.0196 0.6066
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0068 0.0434
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0015 0.0541
Loa Loa (eye worm) hypothetical protein 0.0139 0.0139 0.1652
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0038 0.1354
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0035 0.0015 0.0466
Brugia malayi ecdysone receptor 0.0024 0.0003 0.0032
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0003 0.0017
Schistosoma mansoni smad 0.0022 0 0.0001
Loa Loa (eye worm) beta-lactamase 0.0257 0.0279 0.3311
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0044 0.1371
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.002 0.0241
Brugia malayi Cathepsin L-like precursor 0.0049 0.0032 0.0382
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0036 0.0228
Leishmania major cathepsin L-like protease 0.0188 0.0196 0.6066
Loa Loa (eye worm) hypothetical protein 0.0055 0.0039 0.046
Loa Loa (eye worm) cysteine protease 0.0049 0.0032 0.0382
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0003 0.0032
Schistosoma mansoni lamin 0.03 0.033 0.2112
Plasmodium vivax vivapain-3 0.0025 0.0004 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.0035 0.0417
Brugia malayi Cathepsin L-like precursor 0.0033 0.0013 0.0153
Onchocerca volvulus 0.0257 0.0279 0.8451
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0023 0.0705
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0032 0.1154
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0009 0.0338
Schistosoma mansoni metabotropic glutamate receptor 0.0074 0.0061 0.0392
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0003 0.0017
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0004 0.0119
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0052 0.0035 0.0034
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.002 0.0019
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0049 0.0032 0.0105
Loa Loa (eye worm) hypothetical protein 0.0084 0.0073 0.087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0032 0.1154
Loa Loa (eye worm) MH2 domain-containing protein 0.0022 0 0.0002
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0031 0.0101
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0023 0.0809
Brugia malayi hypothetical protein 0.0024 0.0003 0.0032
Loa Loa (eye worm) hypothetical protein 0.0145 0.0146 0.1729
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0068 0.0436
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0036 0.0116
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0068 0.0067
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.01 0.0093 0.0593
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0019 0.068
Leishmania major hypothetical protein, conserved 0.0028 0.0006 0.02
Mycobacterium leprae Probable lipase LipE 0.0257 0.0279 0.0278
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Loa Loa (eye worm) hypothetical protein 0.0052 0.0035 0.0417
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0147 0.0943
Onchocerca volvulus 0.0049 0.0032 0.097
Schistosoma mansoni hypothetical protein 0.0321 0.0355 0.227
Brugia malayi MH2 domain containing protein 0.005 0.0033 0.0391
Brugia malayi TAR-binding protein 0.0139 0.0139 0.1645
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Mycobacterium ulcerans beta-lactamase 0.0257 0.0279 0.0278
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0068 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0006 0.0231
Brugia malayi Steroid receptor seven-up type 2 0.0052 0.0035 0.0417
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.0035 0.0225
Echinococcus granulosus cathepsin l1 0.0033 0.0013 0.0082
Brugia malayi RNA binding protein 0.0139 0.0139 0.1645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Brugia malayi Papain family cysteine protease containing protein 0.0049 0.0032 0.0382
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0145 0.0146 0.0932
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0257 0.0279 0.3311
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0023 0.0709
Schistosoma mansoni zinc finger protein 0.0024 0.0003 0.0017
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0003 0.0017
Brugia malayi Cathepsin L-like precursor 0.0033 0.0013 0.0153
Schistosoma mansoni cathepsin F (C01 family) 0.0049 0.0032 0.0206
Echinococcus granulosus snurportin 1 0.0321 0.0355 0.227
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0003 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0032 0.1154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0052 0.0035 0.0417
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.0035 0.0417
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0035 0.0417
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0139 0.4305
Echinococcus granulosus tar DNA binding protein 0.0139 0.0139 0.0887
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.002 0.0599
Loa Loa (eye worm) hypothetical protein 0.0052 0.0035 0.0417
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0001 0.0011
Echinococcus multilocularis importin subunit beta 1 0.003 0.0009 0.0031

Activities

Activity type Activity value Assay description Source Reference
Kd (functional) = 3.4 Tested for Alpha adrenergic receptor antagonistic activity on isolated rat vas deferens ChEMBL. 6827543
pA10 (functional) = 2.95 Tested for Alpha adrenergic receptor antagonistic activity on isolated rat vas deferens ChEMBL. 6827543
pA2 (functional) = 3.4 Tested for Alpha adrenergic receptor antagonistic activity on isolated rat vas deferens ChEMBL. 6827543
pA2-pA10 (functional) = 0.45 Tested for Alpha adrenergic receptor antagonistic activity on isolated rat vas deferens ChEMBL. 6827543

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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