Detailed information for compound 143822

Basic information

Technical information
  • TDR Targets ID: 143822
  • Name: 2-(2,5-dimethoxyphenyl)morpholine
  • MW: 223.268 | Formula: C12H17NO3
  • H donors: 1 H acceptors: 0 LogP: 0.89 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1C1CNCCO1)OC
  • InChi: 1S/C12H17NO3/c1-14-9-3-4-11(15-2)10(7-9)12-8-13-5-6-16-12/h3-4,7,12-13H,5-6,8H2,1-2H3
  • InChiKey: ZSSXDMNVMKGEBE-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi metabotropic glutamate receptor type 2 0.0043 0.0025 0.0293
Schistosoma mansoni hypothetical protein 0.0877 0.1014 0.6489
Echinococcus granulosus FTZ F1 alpha 0.0052 0.0035 0.0225
Echinococcus granulosus muscleblind protein 0.0147 0.0148 0.0944
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0036 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.002 0.0627
Onchocerca volvulus 0.0148 0.0149 0.4516
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0068 0.0436
Loa Loa (eye worm) hypothetical protein 0.0027 0.0006 0.0073
Echinococcus granulosus lamin dm0 0.03 0.033 0.2112
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0015 0.0541
Loa Loa (eye worm) hypothetical protein 0.0145 0.0146 0.1729
Echinococcus multilocularis beta LACTamase domain containing family member 0.0257 0.0279 0.0911
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0147 0.0943
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0002 0.0054
Echinococcus granulosus Smad4 0.005 0.0033 0.0211
Plasmodium vivax vivapain-1 0.0025 0.0004 0.0138
Onchocerca volvulus 0.03 0.033 1
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Schistosoma mansoni cellular tumor antigen P53 0.0148 0.0149 0.0955
Loa Loa (eye worm) hypothetical protein 0.0124 0.012 0.143
Echinococcus granulosus tumor protein p63 0.1011 0.1172 0.7503
Brugia malayi Cytochrome P450 family protein 0.0058 0.0043 0.0509
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0003 0.0096
Schistosoma mansoni ferritin light chain 0.0052 0.0035 0.0224
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0003 0.0009
Plasmodium vivax vivapain-2 0.0049 0.0032 0.1154
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.0035 0.0115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0052 0.0035 0.0417
Brugia malayi Calcitonin receptor-like protein seb-1 0.0251 0.0271 0.3219
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.0035 0.0417
Brugia malayi Niemann-Pick C1 protein precursor 0.0213 0.0227 0.2692
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0145 0.0146 0.0932
Brugia malayi steroid hormone receptor 0.0052 0.0035 0.0417
Loa Loa (eye worm) hypothetical protein 0.0049 0.0032 0.0382
Brugia malayi hypothetical protein 0.0027 0.0006 0.0073
Echinococcus multilocularis TGF beta signal transducer SmadC 0.005 0.0033 0.0108
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0032 0.1154
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0002 0.0001
Loa Loa (eye worm) beta-lactamase 0.0257 0.0279 0.3311
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0263 0.0286 0.0935
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0009 0.0291
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0044 0.0043
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0035 0.0015 0.0049
Schistosoma mansoni hypothetical protein 0.0079 0.0068 0.0434
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0038 0.0242
Schistosoma mansoni hypothetical protein 0.005 0.0033 0.0214
Brugia malayi Inositol-1 0.0039 0.0019 0.0231
Schistosoma mansoni hypothetical protein 0.0088 0.0078 0.0502
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0035 0.0115
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0018 0.49
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0038 0.1354
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.002 0.0627
Onchocerca volvulus 0.0024 0.0003 0.0076
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0002 0.0062
Brugia malayi TAR-binding protein 0.0139 0.0139 0.1645
Mycobacterium ulcerans AcrR family transcriptional regulator 0.8456 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0188 0.0196 0.6066
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0251 0.0271 0.3219
Schistosoma mansoni chromobox protein 0.007 0.0056 0.036
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.002 0.0627
Mycobacterium ulcerans hypothetical protein 0.0155 0.0158 0.0157
Echinococcus multilocularis Niemann Pick C1 protein 0.0305 0.0335 0.1095
Brugia malayi Muscleblind-like protein 0.0147 0.0148 0.1751
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0257 0.0279 0.3311
Schistosoma mansoni cathepsin F (C01 family) 0.0049 0.0032 0.0206
Schistosoma mansoni hypothetical protein 0.0088 0.0078 0.0502
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.0035 0.0417
Onchocerca volvulus 0.0024 0.0003 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Loa Loa (eye worm) hypothetical protein 0.0139 0.0139 0.1652
Loa Loa (eye worm) RNA binding protein 0.0139 0.0139 0.1645
Schistosoma mansoni survival motor neuron protein 0.005 0.0033 0.0214
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0003 0.0022
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0257 0.0279 0.1785
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0257 0.0279 0.3311
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0035 0.0225
Echinococcus granulosus microtubule associated protein 2 0.1339 0.1562 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0146 0.0147 0.1748
Mycobacterium leprae conserved hypothetical protein 0.0257 0.0279 0.0278
Echinococcus multilocularis tumor protein p63 0.1011 0.1172 0.3828
Loa Loa (eye worm) nuclear factor I 0.0028 0.0006 0.0077
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0257 0.0279 0.0278
Mycobacterium ulcerans TetR family transcriptional regulator 0.8456 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0003 0.0009
Echinococcus granulosus smad 0.005 0.0033 0.0211
Leishmania major importin beta-1 subunit, putative 0.0024 0.0003 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0002 0.0062
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0044 0.0284
Mycobacterium tuberculosis Conserved protein 0.0257 0.0279 0.0278
Loa Loa (eye worm) cysteine protease 0.0049 0.0032 0.0382
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0139 0.0139 0.1645
Onchocerca volvulus 0.0049 0.0032 0.097
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0003 0.0017
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.002 0.0241
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0006 0.0077
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0146 0.0147 0.1748
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0035 0.0417
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0003 0.0032
Leishmania major cathepsin L-like protease 0.0049 0.0032 0.0994
Trypanosoma brucei unspecified product 0.0039 0.002 0.0627
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0068 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0025 0.0004 0.0564
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0023 0.0809
Echinococcus multilocularis GPCR, family 2 0.0079 0.0068 0.0222
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0049 0.0032 0.1154
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.002 0.0599
Trypanosoma cruzi major cysteine proteinase, putative 0.0148 0.0149 0.4594
Schistosoma mansoni ferritin 0.0052 0.0035 0.0224
Loa Loa (eye worm) hypothetical protein 0.0039 0.002 0.0237
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0001 0.0029
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0009 0.0338
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.002 0.0627
Echinococcus multilocularis protein patched 0.0092 0.0082 0.0269
Trichomonas vaginalis D-aminoacylase, putative 0.0257 0.0279 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0035 0.0417
Loa Loa (eye worm) hypothetical protein 0.0079 0.0068 0.0805
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0035 0.0225
Echinococcus multilocularis muscleblind protein 0.0147 0.0148 0.0482
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0006 0.068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0003 0.0125
Loa Loa (eye worm) hypothetical protein 0.0055 0.0039 0.046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0032 0.1154
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.008 0.0068 0.0812
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0049 0.0032 0.1154
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0035 0.0015 0.0466
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.0035 0.0225
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Schistosoma mansoni nuclear receptor 0.0024 0.0003 0.0017
Echinococcus granulosus dna polymerase eta 0.0039 0.002 0.013
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0006 0.02
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0038 0.1354
Toxoplasma gondii cathepsin CPL 0.0049 0.0032 0.1154
Brugia malayi beta-lactamase 0.0257 0.0279 0.3311
Loa Loa (eye worm) hypothetical protein 0.0147 0.0148 0.1751
Onchocerca volvulus 0.0049 0.0032 0.097
Echinococcus multilocularis smad 0.005 0.0033 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0006 0.018
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.002 0.0627
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.002 0.0627
Brugia malayi chromobox protein homolog 3 0.0039 0.002 0.0237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0013 0.0461
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0139 0.4305
Schistosoma mansoni zinc finger protein 0.0024 0.0003 0.0017
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0263 0.0286 0.1832
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0018 0.0646
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0006 0.004
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0019 0.0697
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.0035 0.0225
Loa Loa (eye worm) hypothetical protein 0.0033 0.0013 0.0153
Brugia malayi Cathepsin L-like precursor 0.0049 0.0032 0.0382
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0147 0.0943
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0147 0.0943
Loa Loa (eye worm) hypothetical protein 0.0171 0.0177 0.2102
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0052 0.0035 0.0115
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0038 0.0448
Entamoeba histolytica hypothetical protein 0.0263 0.0286 1
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0006 0.02
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0039 0.0248
Leishmania major cathepsin L-like protease 0.0049 0.0032 0.0994
Toxoplasma gondii hypothetical protein 0.0027 0.0006 0.0224
Loa Loa (eye worm) steroid hormone receptor 0.0052 0.0035 0.0417
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Toxoplasma gondii ABC1 family protein 0.0257 0.0279 1
Brugia malayi hypothetical protein 0.0263 0.0286 0.3396
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0006 0.018
Brugia malayi conserved hypotetical protein 0.0024 0.0003 0.0032
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0003 0.0017
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0006 0.0073
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0004 0.0134
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0006 0.0918
Onchocerca volvulus 0.0049 0.0032 0.097
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0147 0.0943
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0068 0.0067
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0049 0.0032 0.4723
Loa Loa (eye worm) inositol-1 0.0039 0.0019 0.0231
Brugia malayi Cathepsin L-like precursor 0.0049 0.0032 0.0382
Brugia malayi MH2 domain containing protein 0.005 0.0033 0.0391
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0031 0.0198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Brugia malayi hypothetical protein 0.0247 0.0266 0.3162
Brugia malayi ecdysone receptor 0.0024 0.0003 0.0032
Echinococcus granulosus expressed protein 0.0052 0.0035 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.002 0.013
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Echinococcus multilocularis lamin 0.03 0.033 0.1078
Brugia malayi tailless protein 0.0024 0.0003 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0035 0.0417
Echinococcus multilocularis expressed conserved protein 0.02 0.0211 0.0691
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0002 0.0001
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0139 0.4305
Schistosoma mansoni intermediate filament proteins 0.03 0.033 0.2112
Loa Loa (eye worm) hypothetical protein 0.0027 0.0006 0.0073
Giardia lamblia DINP protein human, muc B family 0.0039 0.002 0.5373
Loa Loa (eye worm) hypothetical protein 0.0084 0.0073 0.087
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.0035 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.0035 0.0417
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0049 0.0032 0.0382
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.8456 1 1
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0003 0.0032
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0015 0.0466
Schistosoma mansoni hypothetical protein 0.0877 0.1014 0.6489
Trichomonas vaginalis D-aminoacylase, putative 0.0257 0.0279 1
Brugia malayi cathepsin L-like precursor 0.0033 0.0013 0.0153
Entamoeba histolytica hypothetical protein 0.0025 0.0003 0.0122
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0077
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0145 0.0146 0.0476
Onchocerca volvulus Cathepsin L homolog 0.0049 0.0032 0.097
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0035 0.0015 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Plasmodium vivax unspecified product 0.0025 0.0004 0.0138
Echinococcus multilocularis cathepsin L cysteine protease 0.0049 0.0032 0.0105
Brugia malayi MH1 domain containing protein 0.0028 0.0006 0.0077
Loa Loa (eye worm) intermediate filament protein 0.03 0.033 0.3917
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0035 0.0225
Brugia malayi nuclear hormone receptor 0.0024 0.0003 0.0032
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0019 0.0697
Onchocerca volvulus 0.0052 0.0035 0.106
Onchocerca volvulus 0.0049 0.0032 0.097
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0049 0.0032 0.0382
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0031 0.0198
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0006 0.0949
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0003 0.0096
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Onchocerca volvulus 0.03 0.033 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0022 0 0.0002
Echinococcus multilocularis isocitrate dehydrogenase 0.0035 0.0015 0.0049
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0036 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Brugia malayi CHE-14 protein 0.0092 0.0082 0.0977
Schistosoma mansoni cathepsin F (C01 family) 0.0049 0.0032 0.0206
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0001 0.0011
Echinococcus granulosus cysteine protease 0.0025 0.0004 0.0025
Echinococcus granulosus metabotropic glutamate receptor 5 0.0109 0.0102 0.0656
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0139 0.0887
Brugia malayi MH2 domain containing protein 0.005 0.0033 0.0391
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.002 0.0627
Onchocerca volvulus 0.0031 0.001 0.0296
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.014 0.0895
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.0324 1
Brugia malayi Intermediate filament tail domain containing protein 0.03 0.033 0.3917
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0068 1
Onchocerca volvulus 0.0049 0.0032 0.097
Brugia malayi Receptor family ligand binding region containing protein 0.0023 0.0001 0.0006
Brugia malayi Cathepsin L-like precursor 0.0049 0.0032 0.0382
Onchocerca volvulus 0.0257 0.0279 0.8451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0004 0.0119
Brugia malayi latrophilin 2 splice variant baaae 0.0171 0.0177 0.2102
Trypanosoma brucei protein kinase, putative 0.0054 0.0038 0.1166
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0019 0.0124
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0044 0.1371
Brugia malayi hypothetical protein 0.0124 0.012 0.143
Onchocerca volvulus Huntingtin homolog 0.0124 0.012 0.3646
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Echinococcus granulosus chromobox protein 1 0.007 0.0056 0.036
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0251 0.0271 0.3219
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0112
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0003 0.0009
Onchocerca volvulus 0.0257 0.0279 0.8451
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0038 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0002 0.0255
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0003 0.0032
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0035 0.0225
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Echinococcus granulosus expressed conserved protein 0.02 0.0211 0.1353
Loa Loa (eye worm) hypothetical protein 0.0124 0.012 0.143
Schistosoma mansoni transcription factor LCR-F1 0.0263 0.0286 0.1832
Echinococcus granulosus TGF beta signal transducer SmadC 0.005 0.0033 0.0211
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0001 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0147 0.0943
Loa Loa (eye worm) acetyltransferase 0.014 0.014 0.1659
Echinococcus multilocularis Smad4 0.005 0.0033 0.0108
Loa Loa (eye worm) TAR-binding protein 0.0139 0.0139 0.1645
Mycobacterium ulcerans hypothetical protein 0.0257 0.0279 0.0278
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0019 0.0697
Schistosoma mansoni metabotropic glutamate receptor 0.0043 0.0025 0.0158
Brugia malayi Smad1 0.005 0.0033 0.0391
Plasmodium falciparum importin beta, putative 0.003 0.0009 0.1383
Echinococcus multilocularis geminin 0.0877 0.1014 0.3311
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0019 0.068
Echinococcus multilocularis sterol regulatory element binding protein 0.0092 0.0082 0.0269
Brugia malayi cytoplasmic intermediate filament protein 0.0161 0.0165 0.1954
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0023 0.0709
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.002 0.0241
Leishmania major cytochrome p450-like protein 0.0028 0.0006 0.02
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0032 0.1154
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0139 0.0887
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0147 0.0481
Loa Loa (eye worm) hypothetical protein 0.0027 0.0006 0.0073
Echinococcus multilocularis importin subunit beta 1 0.003 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0052 0.0035 0.0417
Entamoeba histolytica hypothetical protein 0.0024 0.0002 0.0061
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0003 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Schistosoma mansoni coup transcription factor 0.0052 0.0035 0.0225
Schistosoma mansoni hypothetical protein 0.0079 0.0068 0.0434
Echinococcus multilocularis mothers against decapentaplegic 2 0.0022 0 0.0001
Echinococcus multilocularis lamin dm0 0.03 0.033 0.1078
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0034 0.1041
Echinococcus multilocularis expressed protein 0.0052 0.0035 0.0114
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0257 0.0279 0.0278
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.0035 0.0225
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0032 0.1124
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.002 0.0709
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0035 0.0015 0.0097
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.0035 0.0225
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0015 0.0466
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Brugia malayi Cathepsin L-like precursor 0.0049 0.0032 0.0382
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0006 0.0073
Schistosoma mansoni smad1 5 8 and 0.005 0.0033 0.0211
Echinococcus multilocularis chromobox protein 1 0.007 0.0056 0.0183
Loa Loa (eye worm) hypothetical protein 0.0092 0.0082 0.0977
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0052 0.0035 0.0417
Brugia malayi Papain family cysteine protease containing protein 0.0049 0.0032 0.0382
Loa Loa (eye worm) fibroinase 0.0049 0.0032 0.0382
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0068 0.0067
Schistosoma mansoni importin beta-1 0.003 0.0009 0.006
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.03 0.033 0.3917
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.0035 0.0115
Echinococcus granulosus cathepsin L 0.0025 0.0004 0.0025
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0003 0.0017
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0002 0.0062
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0068 0.0434
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0003 0.0032
Echinococcus granulosus GPCR family 2 0.0079 0.0068 0.0434
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.0035 0.0225
Brugia malayi hypothetical protein 0.0024 0.0003 0.0032
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.002 0.013
Trichomonas vaginalis chromobox protein, putative 0.007 0.0056 0.2014
Loa Loa (eye worm) hypothetical protein 0.0139 0.0139 0.1652
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.002 0.0627
Brugia malayi Cytochrome P450 family protein 0.0028 0.0006 0.0077
Echinococcus multilocularis ferritin 0.0052 0.0035 0.0114
Onchocerca volvulus 0.005 0.0033 0.1008
Leishmania major cysteine peptidase A (CPA) 0.0049 0.0032 0.0994
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0003 0.0125
Brugia malayi MH2 domain containing protein 0.0733 0.0842 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0001 0.0032
Loa Loa (eye worm) hypothetical protein 0.0251 0.0271 0.3219
Plasmodium falciparum cysteine proteinase falcipain 3 0.0049 0.0032 0.4723
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0074 0.0061 0.02
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0031 0.0366
Echinococcus granulosus mothers against decapentaplegic 5 0.005 0.0033 0.0211
Schistosoma mansoni ferritin 0.0052 0.0035 0.0224
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0003 0.0032
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.0035 0.0115
Schistosoma mansoni hypothetical protein 0.0088 0.0078 0.0502
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0002 0.0001
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0003 0.0017
Loa Loa (eye worm) hypothetical protein 0.0257 0.0279 0.3311
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Entamoeba histolytica hypothetical protein 0.0024 0.0003 0.0093
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0279 0.8615
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0003 0.0017
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0002 0.0001
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0039 0.046
Echinococcus granulosus cathepsin l1 0.0033 0.0013 0.0082
Echinococcus multilocularis musashi 0.03 0.033 0.1078
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0038 0.1166
Mycobacterium tuberculosis Probable lipase LipE 0.0257 0.0279 0.0278
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0044 0.1591
Leishmania major cathepsin L-like protease 0.0188 0.0196 0.6066
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0001 0.0029
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0031 0.0198
Brugia malayi nuclear receptor RXR 0.0027 0.0006 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.0035 0.0417
Schistosoma mansoni hypothetical protein 0.0251 0.0272 0.1739
Trypanosoma cruzi cysteine peptidase, putative 0.0049 0.0032 0.0994
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0052 0.0035 0.0417
Brugia malayi intermediate filament protein 0.03 0.033 0.3917
Schistosoma mansoni hypothetical protein 0.0293 0.0321 0.2055
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0023 0.0001 0.0006
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0023 0.0809
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0004 0.0046
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0035 0.0015 0.0014
Mycobacterium ulcerans lipase LipD 0.0257 0.0279 0.0278
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0073 0.0239
Loa Loa (eye worm) hypothetical protein 0.0257 0.0279 0.3311
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0015 0.0049
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0003 0.0017
Schistosoma mansoni smad 0.005 0.0033 0.0211
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0257 0.0279 0.1785
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0023 0.0709
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0052 0.0035 0.5012
Brugia malayi MH1 domain containing protein 0.005 0.0033 0.0391
Loa Loa (eye worm) isocitrate dehydrogenase 0.0035 0.0015 0.0179
Brugia malayi MH1 domain containing protein 0.005 0.0033 0.0391
Leishmania major cathepsin L-like protease 0.0049 0.0032 0.0994
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.0035 0.0417
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0073 0.0469
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0035 0.0417
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0015 0.0541
Onchocerca volvulus 0.0049 0.0032 0.097
Brugia malayi Cathepsin L-like precursor 0.0049 0.0032 0.0382
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0006 0.0232
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0139 0.0887
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Brugia malayi Probable ClpP-like protease 0.008 0.0068 0.0809
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.0035 0.0225
Entamoeba histolytica cysteine proteinase 1, putative 0.0025 0.0004 0.0134
Schistosoma mansoni DNA polymerase eta 0.0039 0.002 0.013
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0006 0.02
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0019 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0279 0.8615
Mycobacterium ulcerans bacterioferritin BfrB 0.0052 0.0035 0.0034
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0049 0.0032 0.4723
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0003 0.0017
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0015 0.0466
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0019 0.0697
Entamoeba histolytica cysteine protease, putative 0.0049 0.0032 0.1124
Schistosoma mansoni ferritin 0.0052 0.0035 0.0224
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.002 0.0627
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0031 0.0198
Brugia malayi hypothetical protein 0.0024 0.0003 0.0032
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0011
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.002 0.0627
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.002 0.0627
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0035 0.0417
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0171 0.0177 0.5469
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0032 0.1154
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0158 0.0157
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0025 0.0004 0.0025
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0006 0.0949
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0006 0.02
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0032 0.1154
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0004 0.0134
Plasmodium vivax importin-beta 2, putative 0.003 0.0009 0.0338
Echinococcus multilocularis cathepsin L cysteine protease 0.0049 0.0032 0.0105
Schistosoma mansoni hypothetical protein 0.0321 0.0355 0.227
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0004 0.0119
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0019 0.0601
Echinococcus multilocularis mothers against decapentaplegic 6 0.0022 0 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Loa Loa (eye worm) hypothetical protein 0.0033 0.0013 0.0153
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0006 0.0073
Echinococcus multilocularis mothers against decapentaplegic 5 0.005 0.0033 0.0108
Echinococcus granulosus geminin 0.0877 0.1014 0.6489
Schistosoma mansoni inositol monophosphatase 0.0039 0.0019 0.0124
Loa Loa (eye worm) hypothetical protein 0.0039 0.002 0.0241
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.002 0.0019
Mycobacterium leprae Probable lipase LipE 0.0257 0.0279 0.0278
Brugia malayi RNA binding protein 0.0139 0.0139 0.1645
Loa Loa (eye worm) hypothetical protein 0.0295 0.0323 0.384
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0052 0.0035 0.106
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0023 0.0809
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0004 0.0119
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0023 0.0709
Loa Loa (eye worm) hypothetical protein 0.0112 0.0107 0.1267
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0032 0.1154
Schistosoma mansoni apoferritin-2 0.0052 0.0035 0.0224
Brugia malayi Isocitrate dehydrogenase 0.0035 0.0015 0.0179
Loa Loa (eye worm) hypothetical protein 0.0247 0.0266 0.3162
Mycobacterium ulcerans esterase/lipase LipP 0.0257 0.0279 0.0278
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0038 0.1166
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0038 0.0242
Mycobacterium ulcerans beta-lactamase 0.0257 0.0279 0.0278
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0001 0.0011
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0031 0.0101
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0052 0.0035 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.0035 0.0417
Echinococcus granulosus cathepsin L cysteine proteinase 0.0049 0.0032 0.0206
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0003 0.0009
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.014 0.0457
Loa Loa (eye worm) hypothetical protein 0.0033 0.0013 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.0035 0.0417
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.0279 0.8615
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0006 0.0077
Brugia malayi Cathepsin L-like precursor 0.0033 0.0013 0.0153
Echinococcus granulosus cathepsin L cysteine protease 0.0025 0.0004 0.0025
Brugia malayi mothers against decapentaplegic homolog 3 0.0022 0 0.0002
Echinococcus granulosus Niemann Pick C1 protein 0.0213 0.0227 0.1452
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0068 0.2443
Brugia malayi Steroid receptor seven-up type 2 0.0052 0.0035 0.0417
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.0035 0.0115
Schistosoma mansoni nuclear receptor 0.0024 0.0003 0.0017
Onchocerca volvulus 0.0048 0.0031 0.093
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0068 1
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0052 0.0035 0.0034
Onchocerca volvulus Huntingtin homolog 0.0124 0.012 0.3646
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.014 0.1659
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0003 0.0108
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0139 0.4305
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0031 0.0101
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0148 0.0482
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0068 0.0436
Entamoeba histolytica cysteine proteinase 2 0.0025 0.0004 0.0134
Schistosoma mansoni ferritin light chain 0.0052 0.0035 0.0224
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0044 0.0284
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0004 0.0134
Brugia malayi mbt repeat family protein 0.0048 0.0031 0.0366
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0039 0.0248
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.002 0.0019
Echinococcus multilocularis dna polymerase kappa 0.0039 0.002 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0035 0.0417
Loa Loa (eye worm) ctsf protein 0.0049 0.0032 0.0382
Echinococcus multilocularis tar DNA binding protein 0.0139 0.0139 0.0453
Schistosoma mansoni thyroid hormone receptor 0.0303 0.0333 0.2133
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0019 0.0601
Brugia malayi hypothetical protein 0.0027 0.0006 0.0073
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0023 0.0144
Brugia malayi Importin beta-1 subunit 0.003 0.0009 0.0112
Schistosoma mansoni ferritin 0.0052 0.0035 0.0224
Trypanosoma cruzi cysteine peptidase, putative 0.0188 0.0196 0.6066
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Loa Loa (eye worm) hypothetical protein 0.008 0.0068 0.0809
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0035 0.0015 0.0466
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0031 0.093
Schistosoma mansoni microtubule-associated protein tau 0.1339 0.1562 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.002 0.0627
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0023 0.0841
Onchocerca volvulus 0.0023 0.0001 0.0022
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0056 0.0667
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0015 0.0049
Trypanosoma cruzi cruzipain precursor, putative 0.0188 0.0196 0.6066
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0025 0.0004 0.0025
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0068 0.0805
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0004 0.0138
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0251 0.0272 0.1739
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0003 0.0096
Onchocerca volvulus 0.0257 0.0279 0.8451
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0023 0.0705
Loa Loa (eye worm) hypothetical protein 0.0147 0.0148 0.1751
Mycobacterium tuberculosis Probable hydrolase 0.0257 0.0279 0.0278
Treponema pallidum bacterioferrin (TpF1) 0.0052 0.0035 0.5012
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.0324 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0006 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0006 0.0231
Brugia malayi MAP kinase sur-1 0.0054 0.0038 0.0448
Loa Loa (eye worm) hypothetical protein 0.0052 0.0035 0.0417
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0257 0.0279 0.0278
Loa Loa (eye worm) hypothetical protein 0.0048 0.0031 0.0366
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0003 0.0009
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0036 0.0228
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0068 0.0434
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0003 0.0032
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0019 0.0019
Schistosoma mansoni metabotropic glutamate receptor 0.0074 0.0061 0.0392
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0068 0.0222
Brugia malayi hypothetical protein 0.0028 0.0006 0.0077
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0019 0.0601
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0013 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0006 0.0231
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0049 0.0032 0.0105
Entamoeba histolytica hypothetical protein 0.0263 0.0286 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0038 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.0035 0.0417
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0038 0.1166
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.002 0.0627
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0025 0.0004 0.0119
Loa Loa (eye worm) transcription factor SMAD2 0.0733 0.0842 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0039 0.0248
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0006 0.0006
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0009 0.0291
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0052 0.0035 0.0034
Echinococcus granulosus ferritin 0.0052 0.0035 0.0224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0052 0.0035 0.0417
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0044 0.0145
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.0199 0.1273
Loa Loa (eye worm) hypothetical protein 0.0052 0.0035 0.0417
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0092 0.0082 0.0977
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0052 0.0035 0.0417
Echinococcus granulosus dna polymerase kappa 0.0039 0.002 0.013
Trichomonas vaginalis chromobox protein, putative 0.007 0.0056 0.2014
Echinococcus multilocularis chromobox protein 1 0.007 0.0056 0.0183
Schistosoma mansoni lamin 0.03 0.033 0.2112
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0015 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Echinococcus granulosus metabotropic glutamate receptor 2 0.0074 0.0061 0.0392
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0068 0.2443
Loa Loa (eye worm) glutamate receptor 0.0088 0.0078 0.0929
Echinococcus granulosus tar DNA binding protein 0.0139 0.0139 0.0887
Trichomonas vaginalis penicillin-binding protein, putative 0.0257 0.0279 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.0035 0.0225
Mycobacterium tuberculosis Probable esterase LipL 0.0257 0.0279 0.0278
Loa Loa (eye worm) MBCTL1 0.0055 0.0039 0.046
Loa Loa (eye worm) hypothetical protein 0.0148 0.0149 0.177
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.002 0.0727
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.002 0.0627
Echinococcus multilocularis Niemann Pick C1 protein 0.0213 0.0227 0.0741
Trypanosoma brucei unspecified product 0.0027 0.0006 0.018
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0073 0.0469
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0038 0.1354
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0068 0.0805
Onchocerca volvulus 0.0033 0.0013 0.0384
Brugia malayi mbt repeat family protein 0.0048 0.0031 0.0366
Plasmodium vivax hypothetical protein, conserved 0.0257 0.0279 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.002 0.0715
Brugia malayi isocitrate dehydrogenase 0.0035 0.0015 0.0179
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0004 0.0134
Brugia malayi nuclear receptor NHR-88 0.0052 0.0035 0.0417
Trypanosoma cruzi cysteine protease, putative 0.0025 0.0004 0.0119
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0006 0.002
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0006 0.0224
Schistosoma mansoni lamin 0.03 0.033 0.2112
Echinococcus granulosus cathepsin l1 0.0049 0.0032 0.0206
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0001 0.0029
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0004 0.0046
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0003 0.0017
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0044 0.0284
Trichomonas vaginalis D-aminoacylase, putative 0.0257 0.0279 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.002 0.013
Echinococcus multilocularis cysteine protease 0.0049 0.0032 0.0105
Echinococcus granulosus mothers against decapentaplegic 2 0.0022 0 0.0001
Echinococcus multilocularis microtubule associated protein 2 0.1339 0.1562 0.5103
Brugia malayi nuclear receptor NHR-88 0.0024 0.0003 0.0032
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0001 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.002 0.0627
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0044 0.0043
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.0035 0.0225
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0002 0.0054
Loa Loa (eye worm) hypothetical protein 0.0257 0.0279 0.3311
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0013 0.0449
Brugia malayi RNA, U transporter 1 0.0086 0.0075 0.0893
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0257 0.0279 0.0278
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0068 0.0222
Schistosoma mansoni smad1 5 8 and 0.005 0.0033 0.0211
Trichomonas vaginalis esterase, putative 0.0257 0.0279 1
Leishmania major DNA polymerase kappa, putative 0.0039 0.002 0.0627
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0023 0.0809
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0006 0.0005
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.0324 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0033 0.0013 0.0153
Schistosoma mansoni hypothetical protein 0.0079 0.0068 0.0434
Schistosoma mansoni hypothetical protein 0.0171 0.0177 0.1133
Brugia malayi MH2 domain containing protein 0.0022 0 0.0002
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0036 0.0035
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0038 0.1354
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0006 0.018
Echinococcus granulosus lamin 0.03 0.033 0.2112
Schistosoma mansoni Smad4 0.005 0.0033 0.0211
Schistosoma mansoni TGF-beta signal transducer Smad2 0.005 0.0033 0.0211
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0251 0.0272 0.0888
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0161 0.0165 0.1954
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.002 0.0727
Echinococcus granulosus Niemann Pick C1 protein 0.0305 0.0335 0.2147
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0003 0.0022
Brugia malayi ecdysteroid receptor 0.0052 0.0035 0.0417
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.0035 0.0115
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0038 0.1166
Onchocerca volvulus Cathepsin F homolog 0.0049 0.0032 0.097
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0032 0.1154
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0023 0.0709
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0006 0.004
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0031 0.0198
Loa Loa (eye worm) hypothetical protein 0.03 0.033 0.3917
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0035 0.0417
Leishmania major cathepsin L-like protease 0.0049 0.0032 0.0994
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0039 0.0127
Mycobacterium ulcerans transcriptional regulator 0.8456 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0 0.0002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0003 0.0041
Loa Loa (eye worm) Smad1 0.005 0.0033 0.0391
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0006 0.02
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0011
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0006 0.0077
Loa Loa (eye worm) hypothetical protein 0.0052 0.0035 0.0417
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0003 0.0032
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0035 0.0015 0.0541
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0038 0.0123
Leishmania major hypothetical protein, conserved 0.0257 0.0279 0.8615
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0068 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0068 0.2443
Schistosoma mansoni Smad4 0.0022 0 0.0001
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.0266 0.1705
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.0035 0.0225
Loa Loa (eye worm) hypothetical protein 0.0257 0.0279 0.3311
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Echinococcus granulosus snurportin 1 0.0321 0.0355 0.227
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0003 0.0011
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0003 0.0017
Brugia malayi nuclear hormone receptor 0.0052 0.0035 0.0417
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.002 0.0627
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0013 0.0461
Echinococcus multilocularis dna polymerase eta 0.0039 0.002 0.0066
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 0.0243 0.2887
Entamoeba histolytica cysteine protease, putative 0.0025 0.0004 0.0134
Echinococcus granulosus beta LACTamase domain containing family member 0.0257 0.0279 0.1785
Echinococcus granulosus cathepsin l cysteine peptidase 0.0049 0.0032 0.0206
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0032 0.1154
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0033 0.0397
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0321 0.0355 0.421
Trypanosoma cruzi cysteine proteinase, putative 0.0025 0.0004 0.0119
Schistosoma mansoni thyroid hormone receptor 0.0303 0.0333 0.2133
Loa Loa (eye worm) hypothetical protein 0.0052 0.0035 0.0417
Onchocerca volvulus 0.0084 0.0073 0.2217
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.002 0.0066
Loa Loa (eye worm) hypothetical protein 0.0109 0.0102 0.1216
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0049 0.0032 0.0105
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.0035 0.0225
Loa Loa (eye worm) hypothetical protein 0.0257 0.0279 0.3311
Echinococcus granulosus chromobox protein 1 0.007 0.0056 0.036
Brugia malayi Heterochromatin protein 1 0.007 0.0056 0.0667
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0003 0.0032
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0038 0.1166
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0068 0.0223
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0139 0.0887
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0006 0.02
Onchocerca volvulus Protein ultraspiracle homolog 0.0052 0.0035 0.106
Loa Loa (eye worm) hypothetical protein 0.0052 0.0035 0.0417
Plasmodium vivax vivapain-2 0.0049 0.0032 0.1154
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0039 0.0127
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.0266 0.087
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.0035 0.0225
Schistosoma mansoni hypothetical protein 0.0088 0.0078 0.0502
Brugia malayi beta-lactamase family protein 0.0257 0.0279 0.3311
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.0035 0.0225
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0044 0.0043
Leishmania major cathepsin L-like protease 0.0188 0.0196 0.6066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.002 0.0241
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.0077
Echinococcus multilocularis cysteine protease 0.0049 0.0032 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.002 0.0715
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0052 0.0035 0.0417
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0082 0.2952
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Brugia malayi MH1 domain containing protein 0.0028 0.0006 0.0077
Brugia malayi Cathepsin L-like precursor 0.0033 0.0013 0.0153
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0032 0.1154
Echinococcus granulosus importin subunit beta 1 0.003 0.0009 0.006
Schistosoma mansoni Smad4 0.0022 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0038 0.0242
Schistosoma mansoni smad1 5 8 and 0.005 0.0033 0.0211
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.002 0.0019
Brugia malayi RNA recognition motif domain containing protein 0.0139 0.0139 0.1645
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.002 0.0627
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0032 0.1124
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0139 0.0887
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0038 0.1166
Loa Loa (eye worm) hypothetical protein 0.0052 0.0035 0.0417
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0015 0.0014
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.0135 0.0865
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0025 0.0004 0.0025
Mycobacterium tuberculosis Conserved protein 0.0257 0.0279 0.0278
Echinococcus granulosus sterol regulatory element binding protein 0.0092 0.0082 0.0527
Loa Loa (eye worm) MH2 domain-containing protein 0.0733 0.0842 1
Onchocerca volvulus Cathepsin L homolog 0.0049 0.0032 0.097
Schistosoma mansoni chromobox protein 0.007 0.0056 0.036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Trypanosoma cruzi cysteine proteinase, putative 0.0025 0.0004 0.0119
Echinococcus multilocularis cathepsin L 0.0025 0.0004 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Brugia malayi beta-lactamase family protein 0.0257 0.0279 0.3311
Echinococcus granulosus mothers against decapentaplegic 6 0.0022 0 0.0001
Schistosoma mansoni patched 1 0.0092 0.0082 0.0527
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0044 0.0043
Brugia malayi Cathepsin L-like precursor 0.0049 0.0032 0.0382
Mycobacterium tuberculosis Probable lipase LipD 0.0257 0.0279 0.0278
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0043 0.0509
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0068 0.0067
Leishmania major hypothetical protein, conserved 0.0028 0.0006 0.02
Leishmania major DNA polymerase eta, putative 0.0039 0.002 0.0627
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0213 0.0227 0.7925
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0217 0.0231 0.1477
Onchocerca volvulus Bile acid receptor homolog 0.0052 0.0035 0.106
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0023 0.0001 0.0006
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0038 0.1166
Schistosoma mansoni smad 0.0022 0 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0196 0.6066
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0003 0.0017
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0035 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.002 0.0627
Loa Loa (eye worm) hypothetical protein 0.0213 0.0227 0.2692
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0073 0.087
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0018 0.2715
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.0199 0.0649
Brugia malayi follicle stimulating hormone receptor 0.0227 0.0243 0.2887
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0003 0.0017
Brugia malayi nuclear receptor RXR 0.0024 0.0003 0.0032
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.01 0.0093 0.0593
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0003 0.0083
Onchocerca volvulus 0.0049 0.0032 0.097
Loa Loa (eye worm) glutamate receptor 0.0035 0.0015 0.0176
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0068 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0035 0.0417
Plasmodium vivax vivapain-3 0.0025 0.0004 0.0138
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0003 0.0032
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0118
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0023 0.0841
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.002 0.0627
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0032
Loa Loa (eye worm) MH1 domain-containing protein 0.0022 0 0.0002
Trypanosoma brucei unspecified product 0.0027 0.0006 0.018
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0052 0.0035 0.0034
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2604 0.3061 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0006 0.0073
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1644 0.1923 0.1923
Echinococcus multilocularis snurportin 1 0.0321 0.0355 0.1159
Trichomonas vaginalis penicillin-binding protein, putative 0.0257 0.0279 1
Brugia malayi nuclear receptor NHR-67 0.0024 0.0003 0.0032
Echinococcus granulosus intermediate filament protein 0.03 0.033 0.2112
Echinococcus granulosus Protein patched homolog 1 0.0092 0.0082 0.0527
Schistosoma mansoni inositol monophosphatase 0.0039 0.0019 0.0124
Loa Loa (eye worm) MH1 domain-containing protein 0.005 0.0033 0.0391
Loa Loa (eye worm) DR-78 0.0024 0.0003 0.0032
Toxoplasma gondii hypothetical protein 0.0048 0.003 0.1082
Brugia malayi Metabotropic glutamate receptor precursor. 0.0088 0.0078 0.0929
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0001 0.0032
Loa Loa (eye worm) hypothetical protein 0.0027 0.0006 0.0073
Echinococcus multilocularis thyroid hormone receptor alpha 0.0303 0.0333 0.1088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0004 0.0138
Leishmania major cathepsin L-like protease 0.0188 0.0196 0.6066
Schistosoma mansoni apoferritin-2 0.0052 0.0035 0.0224
Brugia malayi Cytochrome P450 family protein 0.0028 0.0006 0.0077
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0023 0.0809
Trichomonas vaginalis ferritin, putative 0.0052 0.0035 0.1255
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0052 0.0035 0.0417
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0036 0.0035
Loa Loa (eye worm) MH2 domain-containing protein 0.005 0.0033 0.0391
Mycobacterium tuberculosis Conserved protein 0.0257 0.0279 0.0278
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0035 0.0015 0.2214
Loa Loa (eye worm) hypothetical protein 0.0257 0.0279 0.3311
Entamoeba histolytica hypothetical protein 0.0263 0.0286 1
Schistosoma mansoni hypothetical protein 0.0079 0.0068 0.0434
Leishmania major cathepsin L-like protease 0.0049 0.0032 0.0994
Trypanosoma cruzi cysteine peptidase, putative 0.0188 0.0196 0.6066
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0003 0.0076
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0006 0.0232
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0019 0.0601
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0109 0.0102 0.0335
Mycobacterium ulcerans bacterioferritin BfrA 0.0052 0.0035 0.0034
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0003 0.0108
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0038 0.1354
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0068 0.0805
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0147 0.0481
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0032 0.1154
Echinococcus multilocularis protein dispatched 1 0.0105 0.0098 0.0319
Schistosoma mansoni hypothetical protein 0.0263 0.0286 0.1832
Entamoeba histolytica hypothetical protein 0.0263 0.0286 1
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.0324 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.002 0.0627
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0019 0.2667

Activities

Activity type Activity value Assay description Source Reference
Kd (functional) = 3.4 Tested for Alpha adrenergic receptor antagonistic activity on isolated rat vas deferens ChEMBL. 6827543
pA10 (functional) = 2.95 Tested for Alpha adrenergic receptor antagonistic activity on isolated rat vas deferens ChEMBL. 6827543
pA2 (functional) = 3.4 Tested for Alpha adrenergic receptor antagonistic activity on isolated rat vas deferens ChEMBL. 6827543
pA2-pA10 (functional) = 0.45 Tested for Alpha adrenergic receptor antagonistic activity on isolated rat vas deferens ChEMBL. 6827543

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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