Detailed information for compound 1450131

Basic information

Technical information
  • TDR Targets ID: 1450131
  • Name: N-(5-ethyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c ]pyridin-2-yl)-3,3-di(phenyl)propanamide
  • MW: 391.529 | Formula: C23H25N3OS
  • H donors: 1 H acceptors: 2 LogP: 4.11 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCc2c(C1)sc(n2)NC(=O)CC(c1ccccc1)c1ccccc1
  • InChi: 1S/C23H25N3OS/c1-2-26-14-13-20-21(16-26)28-23(24-20)25-22(27)15-19(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-12,19H,2,13-16H2,1H3,(H,24,25,27)
  • InChiKey: VUVNBAXJXHPVCH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(5-ethyl-6,7-dihydro-4H-thiazolo[5,4-c]pyridin-2-yl)-3,3-di(phenyl)propanamide
  • N-(5-ethyl-6,7-dihydro-4H-thiazolo[5,4-c]pyridin-2-yl)-3,3-di(phenyl)propionamide
  • T5309709
  • MLS000566668
  • SMR000153580

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0224 0.1611 0.1611
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0184 0.0629
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0026 0.0044
Schistosoma mansoni polycystin 1-related 0.002 0.0051 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.023 0.0807
Schistosoma mansoni growth hormone secretagogue receptor 0.0123 0.0833 0.081
Schistosoma mansoni hypothetical protein 0.0123 0.0833 0.081
Brugia malayi hypothetical protein 0.0123 0.0833 0.0823
Trichomonas vaginalis guanylate cyclase beta 2 subunit, putative 0.0017 0.0026 0.0044
Echinococcus granulosus tachykinin peptides receptor 99D 0.0123 0.0833 0.0833
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0183 0.0183
Treponema pallidum sodium- and chloride- dependent transporter 0.1322 1 1
Brugia malayi N-terminal motif family protein 0.02 0.1426 0.1416
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0036 0.006
Schistosoma mansoni sodium/chloride dependent transporter 0.1322 1 1
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0028 0.0111 0.0111
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0028 0.0111 0.0479
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0048 0.0048
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0123 0.0833 0.0833
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.023 0.0219
Echinococcus granulosus neuropeptides capa receptor 0.0123 0.0833 0.0833
Schistosoma mansoni alpha glucosidase 0.0044 0.023 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Brugia malayi follicle stimulating hormone receptor 0.0123 0.0833 0.0823
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0204 0.1504
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0051 0.0051
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0224 0.1611 0.1611
Brugia malayi hypothetical protein 0.0123 0.0833 0.0823
Loa Loa (eye worm) norepinephrine transporter 0.1322 1 1
Trichomonas vaginalis guanylate cyclase beta 1 subunit, putative 0.0017 0.0026 0.0044
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0189 0.0648
Brugia malayi Serotonin receptor 0.0123 0.0833 0.0823
Trichomonas vaginalis adenylate cyclase, putative 0.0017 0.0026 0.0044
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.004 0.0204 0.0179
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0123 0.0833 0.0833
Trichomonas vaginalis adenylate cyclase, putative 0.0017 0.0026 0.0044
Brugia malayi hypothetical protein 0.0224 0.1611 0.1602
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0123 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0038 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.1322 1 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.023 0.1231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0026 0.0044
Echinococcus granulosus neuropeptide Y receptor 0.0123 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0182 0.1286 0.1286
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0184 0.0807
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0028 0.0111 0.0086
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0036 0.006
Brugia malayi hypothetical protein 0.0123 0.0833 0.0823
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0184 0.1334
Brugia malayi hypothetical protein 0.0123 0.0833 0.0823
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0026 0.0044
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0088 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.0563 0.8784
Trypanosoma cruzi protein kinase A regulatory subunit 0.0028 0.0111 0.0351
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0048 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0111 0.0745
Brugia malayi neuropeptide F receptor 0.0123 0.0833 0.0823
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0026 0.0044
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0017 0.0026 0.0044
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.004 0.0204 0.0179
Schistosoma mansoni biogenic amine receptor 0.0123 0.0833 0.081
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0026 0.0044
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0123 0.0833 0.0833
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0036 0.0036
Loa Loa (eye worm) glutathione reductase 0.0038 0.0189 0.0189
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.023 0.1712
Loa Loa (eye worm) serotonin transporter b 0.1322 1 1
Echinococcus granulosus serotonin receptor 0.0123 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0123 0.0833 0.0833
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0028 0.0111 0.0111
Echinococcus granulosus rhodopsin orphan GPCR 0.0123 0.0833 0.0833
Brugia malayi Dopamine receptor protein 2 0.0123 0.0833 0.0823
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0366 0.1331
Echinococcus multilocularis cpg binding protein 0.0031 0.0135 0.0135
Echinococcus multilocularis neuropeptide Y receptor 0.0123 0.0833 0.0833
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0123 0.0833 0.0823
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Brugia malayi larval opioid receptor 0.0123 0.0833 0.0823
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1322 1 1
Plasmodium falciparum amino acid transporter, putative 0.0224 0.1611 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0111 0.0111
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0028 0.0111 0.01
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0366 0.0341
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0036 0.006
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0366 0.0366
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0036 0.006
Loa Loa (eye worm) hypothetical protein 0.004 0.0204 0.0204
Brugia malayi hypothetical protein 0.002 0.0051 0.004
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0224 0.1611 0.159
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0028 0.0111 0.0086
Brugia malayi Cyclic-nucleotide gated cation channel 0.004 0.0204 0.0193
Schistosoma mansoni opsin-like receptor 0.0123 0.0833 0.081
Onchocerca volvulus 0.0123 0.0833 0.0815
Trichomonas vaginalis adenylate cyclase, putative 0.0017 0.0026 0.0044
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0051 0.0051
Schistosoma mansoni amine GPCR 0.0123 0.0833 0.081
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0017 0.0026 0.0044
Brugia malayi RE15519p 0.0123 0.0833 0.0823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0017 0.0026 0.0014
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0123 0.0833 0.081
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Echinococcus granulosus g protein coupled receptor 0.0123 0.0833 0.0833
Loa Loa (eye worm) AGC/PKG protein kinase 0.0028 0.0111 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0111 0.0086
Echinococcus granulosus tm gpcr rhodopsin 0.0123 0.0833 0.0833
Echinococcus multilocularis dnaJ subfamily B 0.0817 0.6139 0.6139
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0028 0.0111 0.0111
Echinococcus granulosus g-protein coupled receptor 0.0123 0.0833 0.0833
Brugia malayi CXXC zinc finger family protein 0.003 0.0122 0.0111
Plasmodium falciparum glutathione reductase 0.0038 0.0189 0.088
Echinococcus multilocularis sodium and chloride dependent glycine 0.0224 0.1611 0.1611
Trichomonas vaginalis adenylate cyclase, putative 0.0017 0.0026 0.0044
Echinococcus multilocularis G-protein coupled receptor, putative 0.0123 0.0833 0.0833
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0057 0.0334 0.0334
Trypanosoma cruzi cAMP response protein 1 0.0028 0.0111 0.0351
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0366 0.2093
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0184 0.0184
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.004 0.0204 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0026 0.0044
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0224 0.1611 0.1602
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0189 0.0189
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0048 0.0048
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0026 0.0044
Mycobacterium ulcerans hypothetical protein 0.0028 0.0111 0.2007
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0111 0.0086
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0017 0.0026 0.0044
Onchocerca volvulus 0.0028 0.0111 0.0091
Plasmodium falciparum thioredoxin reductase 0.0038 0.0189 0.088
Loa Loa (eye worm) hypothetical protein 0.0028 0.0111 0.0111
Trichomonas vaginalis adenylate cyclase, putative 0.0017 0.0026 0.0044
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0189 0.088
Trichomonas vaginalis adenylate cyclase, putative 0.0017 0.0026 0.0044
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0224 0.1611 0.159
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0193 0.0193
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0026 0.0044
Trypanosoma brucei trypanothione reductase 0.0038 0.0189 0.0648
Schistosoma mansoni hypothetical protein 0.0123 0.0833 0.081
Trichomonas vaginalis adenylate cyclase type, putative 0.0017 0.0026 0.0044
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0366 1
Plasmodium vivax hypothetical protein, conserved 0.0224 0.1611 1
Echinococcus granulosus lamin 0.0028 0.0111 0.0111
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0026 0.0044
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0038 0.0184 0.0184
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0123 0.0833 0.0833
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0028 0.0111 0.0351
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0123 0.0833 0.0833
Brugia malayi beta-lactamase 0.0038 0.0184 0.0172
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.0638 0.3504
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0184 0.0184
Echinococcus multilocularis serotonin receptor 0.0123 0.0833 0.0833
Trichomonas vaginalis intestinal guanylate cyclase, putative 0.0017 0.0026 0.0044
Entamoeba histolytica hypothetical protein 0.0038 0.0183 0.778
Leishmania major cytochrome p450-like protein 0.002 0.0048 0.0105
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0011 0.0011
Mycobacterium tuberculosis Conserved protein 0.0038 0.0184 0.0807
Brugia malayi Thioredoxin reductase 0.0038 0.0189 0.0177
Onchocerca volvulus 0.0028 0.0111 0.0091
Echinococcus granulosus hyperpolarization activated cyclic 0.004 0.0204 0.0204
Echinococcus multilocularis fmrfamide receptor 0.0123 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0028 0.0111 0.0351
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0122 0.0122
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0188 0.1336 0.1336
Brugia malayi neuropeptide F receptor 0.0123 0.0833 0.0823
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0036 0.006
Loa Loa (eye worm) cytochrome P450 0.002 0.0048 0.0048
Trypanosoma brucei glucosidase, putative 0.0044 0.023 0.0807
Echinococcus granulosus hyperpolarization activated cyclic 0.004 0.0204 0.0204
Onchocerca volvulus 0.0038 0.0184 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0088 0.0555
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0026 0.0044
Echinococcus multilocularis musashi 0.0028 0.0111 0.0111
Echinococcus multilocularis rhodopsin orphan GPCR 0.0123 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0224 0.1611 0.1611
Schistosoma mansoni neuropeptide F-like receptor 0.0123 0.0833 0.081
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.002
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.0563 0.3062
Echinococcus multilocularis RUN 0.002 0.0051 0.0051
Echinococcus granulosus rhodopsin orphan GPCR 0.0123 0.0833 0.0833
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0028 0.0111 0.0351
Brugia malayi Cytochrome P450 family protein 0.002 0.0048 0.0036
Schistosoma mansoni hypothetical protein 0.0028 0.0111 0.0086
Loa Loa (eye worm) hypothetical protein 0.0057 0.0334 0.0334
Entamoeba histolytica hypothetical protein 0.0038 0.0183 0.778
Onchocerca volvulus 0.0028 0.0111 0.0091
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0123 0.0833 0.0823
Mycobacterium tuberculosis Conserved protein 0.0038 0.0184 0.0807
Echinococcus granulosus biogenic amine 5HT receptor 0.0123 0.0833 0.0833
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0123 0.0833 0.081
Trypanosoma brucei Flagellar Member 6 0.0028 0.0111 0.0351
Echinococcus multilocularis somatostatin receptor 0.0123 0.0833 0.0833
Brugia malayi Cytochrome P450 family protein 0.0081 0.0512 0.0501
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0123 0.0833 0.081
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0366 0.0366
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0028 0.0111 0.0479
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0051 0.0051
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0028 0.0111 0.0111
Schistosoma mansoni cpg binding protein 0.003 0.0122 0.0097
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0026 0.0044
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0088 0.0077
Loa Loa (eye worm) hypothetical protein 0.0224 0.1611 0.1611
Loa Loa (eye worm) hypothetical protein 0.016 0.1121 0.1121
Schistosoma mansoni biogenic amine (5HT) receptor 0.0123 0.0833 0.081
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.023 0.1712
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0325 0.1833
Mycobacterium tuberculosis Probable reductase 0.0087 0.0563 0.3062
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.023 0.023
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.004 0.0204 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Onchocerca volvulus Neuropeptide F receptor homolog 0.0123 0.0833 0.0815
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0123 0.0833 0.0833
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0188 0.1336 0.1326
Onchocerca volvulus 0.0114 0.0766 0.0747
Brugia malayi G-protein coupled receptor 0.0123 0.0833 0.0823
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0204 0.1504
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0123 0.0833 0.0823
Brugia malayi beta-lactamase family protein 0.0038 0.0184 0.0172
Plasmodium falciparum cGMP-dependent protein kinase 0.0028 0.0111 0.0385
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0224 0.1611 0.1611
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Loa Loa (eye worm) neuropeptide F receptor 0.0123 0.0833 0.0833
Echinococcus granulosus tm gpcr rhodopsin 0.0123 0.0833 0.0833
Leishmania major cyclic nucleotide-binding protein-like protein 0.0028 0.0111 0.0351
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0036 0.006
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0123 0.0833 0.081
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0188 0.1336 0.1336
Schistosoma mansoni voltage-gated potassium channel 0.0205 0.1466 0.1444
Brugia malayi Dopamine receptor protein 1 0.0123 0.0833 0.0823
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0111 0.0351
Leishmania major protein kinase, putative 0.0028 0.0111 0.0351
Echinococcus granulosus rhodopsin orphan GPCR 0.0123 0.0833 0.0833
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0028 0.0111 0.0351
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.0825 0.0825
Echinococcus granulosus rhodopsin orphan GPCR 0.0123 0.0833 0.0833
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.004 0.0204 0.0179
Schistosoma mansoni sodium/chloride dependent transporter 0.0224 0.1611 0.159
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Trypanosoma cruzi cAMP response protein 1, putative 0.0028 0.0111 0.0351
Onchocerca volvulus 0.0028 0.0111 0.0091
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0123 0.0833 0.0833
Echinococcus multilocularis neuropeptide FF receptor 2 0.0123 0.0833 0.0833
Echinococcus multilocularis rhodopsin orphan GPCR 0.0123 0.0833 0.0833
Echinococcus granulosus tm gpcr rhodopsin 0.0123 0.0833 0.0833
Onchocerca volvulus 0.002 0.0051 0.0031
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0026 0.0044
Schistosoma mansoni neuropeptide receptor 0.0123 0.0833 0.081
Leishmania major regulatory subunit of protein kinase a-like protein 0.0028 0.0111 0.0351
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0204 0.0179
Onchocerca volvulus 0.0224 0.1611 0.1594
Brugia malayi Cytochrome P450 family protein 0.002 0.0048 0.0036
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0176 0.1243 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Echinococcus granulosus dnaJ subfamily B 0.0817 0.6139 0.6139
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.14 0.14
Brugia malayi Cytochrome P450 family protein 0.002 0.0048 0.0036
Echinococcus multilocularis voltage gated potassium channel 0.0057 0.0334 0.0334
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0184 0.0807
Trichomonas vaginalis adenylate cyclase, putative 0.0017 0.0026 0.0044
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0026 0.0044
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.003 0.0127 0.0102
Echinococcus multilocularis neuropeptides capa receptor 0.0123 0.0833 0.0833
Trypanosoma brucei cAMP response protein 1, putative 0.0028 0.0111 0.0351
Echinococcus granulosus neuropeptides capa receptor 0.0123 0.0833 0.0833
Echinococcus multilocularis G protein coupled receptor 139 0.0123 0.0833 0.0833
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0111 0.0111
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0366 1
Onchocerca volvulus 0.002 0.0051 0.0031
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0184 0.4273
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0224 0.1611 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0189 0.0837
Echinococcus granulosus rhodopsin orphan GPCR 0.0123 0.0833 0.0833
Brugia malayi Egg laying defective protein 4 0.0028 0.0111 0.01
Toxoplasma gondii hypothetical protein 0.0224 0.1611 1
Schistosoma mansoni lipoxygenase 0.0085 0.0546 0.0521
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0026 0.0044
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0184 0.0184
Schistosoma mansoni biogenic amine (5HT) receptor 0.0123 0.0833 0.081
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0356 0.2615 0.2607
Onchocerca volvulus 0.0123 0.0833 0.0815
Echinococcus multilocularis rhodopsin orphan GPCR 0.0123 0.0833 0.0833
Trichomonas vaginalis adenylate cyclase, putative 0.0017 0.0026 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.023 0.0807
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Echinococcus granulosus patatin phospholipase domain containing protein 0.0028 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0038 0.0184 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0026 0.0044
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0366 0.1888
Schistosoma mansoni biogenic amine receptor 0.0123 0.0833 0.081
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0028 0.0111 0.0111
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0123 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Schistosoma mansoni rab6-interacting 0.002 0.0051 0.0026
Mycobacterium tuberculosis Conserved hypothetical protein 0.0028 0.0111 0.0379
Onchocerca volvulus 0.0123 0.0833 0.0815
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0224 0.1611 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0028 0.0111 0.0111
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0088 0.0332
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0028 0.0111 0.0379
Echinococcus multilocularis neuropeptide receptor A26 0.0678 0.508 0.508
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.004 0.0204 0.0204
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0028 0.0111 0.0086
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0123 0.0833 0.081
Schistosoma mansoni loxhd1 0.002 0.0051 0.0026
Onchocerca volvulus 0.0123 0.0833 0.0815
Echinococcus multilocularis neuropeptide receptor 0.0123 0.0833 0.0833
Echinococcus multilocularis hyperpolarization activated cyclic 0.004 0.0204 0.0204
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0123 0.0833 0.081
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0036 0.0025
Trichomonas vaginalis adenylate cyclase type VI, putative 0.0017 0.0026 0.0044
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0088 0.0261
Mycobacterium ulcerans lipase LipD 0.0038 0.0184 0.4273
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0123 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Echinococcus granulosus hypothetical protein 0.0123 0.0833 0.0833
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0017 0.0026 0.0044
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0028 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0224 0.1611 0.159
Schistosoma mansoni hypothetical protein 0.0165 0.1157 0.1134
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.0563 0.3062
Echinococcus granulosus 7tm_1 domain containing protein 0.0123 0.0833 0.0833
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.023 0.1712
Toxoplasma gondii hypothetical protein 0.0224 0.1611 1
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.0119 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0026 0.0044
Brugia malayi GnHR receptor homolog 0.0123 0.0833 0.0823
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0026 0.0044
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0028 0.0111 0.0745
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0028 0.0111 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Trichomonas vaginalis esterase, putative 0.0038 0.0184 0.1334
Loa Loa (eye worm) G-protein coupled receptor 0.0123 0.0833 0.0833
Trichomonas vaginalis adenylate cyclase type vIII, putative 0.0017 0.0026 0.0044
Echinococcus multilocularis orexin receptor type 2 0.0123 0.0833 0.0833
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0123 0.0833 0.081
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0224 0.1611 0.1602
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0036 0.0025
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0224 0.1611 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Trichomonas vaginalis adenylate cyclase type, putative 0.0017 0.0026 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Loa Loa (eye worm) G-protein coupled receptor 0.0123 0.0833 0.0833
Brugia malayi intermediate filament protein 0.0028 0.0111 0.01
Entamoeba histolytica hypothetical protein 0.0038 0.0183 0.778
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0026 0.0044
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0224 0.1611 0.159
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0123 0.0833 0.0833
Mycobacterium ulcerans hypothetical protein 0.0028 0.0111 0.2007
Loa Loa (eye worm) neuropeptide F receptor 0.0123 0.0833 0.0833
Brugia malayi Doublecortin family protein 0.002 0.0051 0.004
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0028 0.0111 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Schistosoma mansoni hypothetical protein 0.002 0.0051 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0123 0.0833 0.081
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0028 0.0111 0.0745
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0036 0.0036
Onchocerca volvulus 0.0123 0.0833 0.0815
Echinococcus granulosus neuropeptide receptor 0.0123 0.0833 0.0833
Echinococcus granulosus geminin 0.0165 0.1157 0.1157
Schistosoma mansoni amine GPCR 0.0123 0.0833 0.081
Trypanosoma cruzi cytochrome p450-like protein, putative 0.002 0.0048 0.0105
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0224 0.1611 0.1611
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0123 0.0833 0.081
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.02 0.1426 0.1408
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0188 0.1336 0.1336
Echinococcus multilocularis sodium and chloride dependent glycine 0.0224 0.1611 0.1611
Echinococcus granulosus orexin receptor type 2 0.0123 0.0833 0.0833
Schistosoma mansoni hypothetical protein 0.0038 0.0183 0.0158
Mycobacterium leprae Probable lipase LipE 0.0038 0.0184 0.2578
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0088 0.0063
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0366 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0123 0.0833 0.0815
Loa Loa (eye worm) solute carrier family 6 member 4 0.1322 1 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0036 0.006
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.0563 0.3062
Leishmania major cytochrome p450-like protein 0.002 0.0048 0.0105
Brugia malayi putative neuropeptide receptor NPR1 0.0123 0.0833 0.0823
Trichomonas vaginalis adenylyl cyclase type V, putative 0.0017 0.0026 0.0044
Loa Loa (eye worm) hypothetical protein 0.0224 0.1611 0.1611
Loa Loa (eye worm) CYP4Cod1 0.002 0.0048 0.0048
Echinococcus granulosus sex peptide receptor 0.0123 0.0833 0.0833
Schistosoma mansoni lamin 0.0028 0.0111 0.0086
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0184 0.0807
Mycobacterium tuberculosis Conserved protein 0.0038 0.0184 0.0807
Onchocerca volvulus 0.0123 0.0833 0.0815
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.004 0.0204 0.0204
Brugia malayi Serotonin receptor 0.0123 0.0833 0.0823
Onchocerca volvulus 0.1322 1 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0036 0.0061
Echinococcus multilocularis g protein coupled receptor 0.0123 0.0833 0.0833
Schistosoma mansoni lamin 0.0028 0.0111 0.0086
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0111 0.01
Echinococcus granulosus cyclic nucleotide gated cation channel 0.004 0.0204 0.0204
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0184 0.0807
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0123 0.0833 0.081
Trypanosoma brucei protein kinase A regulatory subunit 0.0028 0.0111 0.0351
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Echinococcus multilocularis 0.002 0.0048 0.0048
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0036 0.006
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0356 0.2615 0.2615
Schistosoma mansoni biogenic amine receptor 0.0123 0.0833 0.081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Brugia malayi sulfakinin receptor protein 0.0123 0.0833 0.0823
Schistosoma mansoni lipoxygenase 0.0122 0.0825 0.0801
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0123 0.0833 0.081
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0184 0.0629
Mycobacterium ulcerans hypothetical protein 0.0028 0.0111 0.2007
Brugia malayi AKH receptor 0.0123 0.0833 0.0823
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0061
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.023 1
Loa Loa (eye worm) hypothetical protein 0.1322 1 1
Mycobacterium ulcerans regulatory protein 0.0028 0.0111 0.2007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0123 0.0833 0.081
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0028 0.0111 0.0385
Schistosoma mansoni myosin xvIII 0.0123 0.0833 0.081
Echinococcus multilocularis neuropeptide receptor 0.0123 0.0833 0.0833
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0028 0.0111 0.0379
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0224 0.1611 0.1611
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0184 0.0158
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0028 0.0111 0.01
Schistosoma mansoni opsin-like receptor 0.0123 0.0833 0.081
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0123 0.0833 0.081
Echinococcus granulosus cytochrome P450 2K1 0.002 0.0048 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0123 0.0833 0.0833
Plasmodium vivax glutathione reductase, putative 0.0038 0.0189 0.088
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0028 0.0111 0.0111
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0123 0.0833 0.0833
Schistosoma mansoni opsin-like receptor 0.0123 0.0833 0.081
Schistosoma mansoni voltage-gated potassium channel 0.0057 0.0334 0.0309
Schistosoma mansoni neuropeptide receptor 0.0123 0.0833 0.081
Trichomonas vaginalis adenylate cyclase, putative 0.0017 0.0026 0.0044
Trypanosoma brucei C-8 sterol isomerase, putative 0.0356 0.2615 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0184 0.1334
Loa Loa (eye worm) TYRA-2 protein 0.0123 0.0833 0.0833
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.14 0.14
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0017 0.0026 0.0021
Echinococcus granulosus 7TM GPCR rhodopsin 0.0123 0.0833 0.0833
Onchocerca volvulus 0.0123 0.0833 0.0815
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0036 0.0744
Mycobacterium ulcerans beta-lactamase 0.0038 0.0184 0.4273
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0057 0.0334 0.0334
Trypanosoma cruzi Flagellar Member 6 0.0028 0.0111 0.0351
Echinococcus granulosus lamin dm0 0.0028 0.0111 0.0111
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0123 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0038 0.0184 0.0184
Echinococcus multilocularis rhodopsin orphan GPCR 0.0123 0.0833 0.0833
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.0638 1
Echinococcus granulosus somatostatin receptor 0.0123 0.0833 0.0833
Schistosoma mansoni amine GPCR 0.0123 0.0833 0.081
Echinococcus granulosus cpg binding protein 0.0031 0.0135 0.0135
Echinococcus multilocularis rhodopsin orphan GPCR 0.0123 0.0833 0.0833
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.023 0.1712
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0028 0.0111 0.0111
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.0563 0.3062
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0026 0.0044
Entamoeba histolytica hypothetical protein 0.0025 0.0088 0.3238
Echinococcus granulosus neuropeptide receptor A26 0.0678 0.508 0.508
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0123 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0183 0.0158
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0123 0.0833 0.0833
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0026 0.0044
Onchocerca volvulus 0.0123 0.0833 0.0815
Onchocerca volvulus 0.0123 0.0833 0.0815
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0123 0.0833 0.081
Schistosoma mansoni neuropeptide receptor 0.0123 0.0833 0.081
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0123 0.0833 0.081
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0026 0.0044
Echinococcus granulosus sodium and chloride dependent glycine 0.0224 0.1611 0.1611
Loa Loa (eye worm) hypothetical protein 0.0525 0.3911 0.3911
Brugia malayi G protein-coupled receptor F59B2.13 0.0123 0.0833 0.0823
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.023 0.1712
Brugia malayi hypothetical protein 0.0038 0.0183 0.0172
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0028 0.0111 0.0745
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0028 0.0111 0.01
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.0638 0.3504
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0048 0.0105
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0036 0.006
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0028 0.0111 0.0111
Echinococcus granulosus alpha 1A adrenergic receptor 0.0123 0.0833 0.0833
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0123 0.0833 0.0823
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0224 0.1611 0.1611
Echinococcus multilocularis sex peptide receptor 0.0123 0.0833 0.0833
Schistosoma mansoni cytochrome P450 0.002 0.0048 0.0022
Echinococcus granulosus peptide allatostatin:somatostatin 0.0123 0.0833 0.0833
Onchocerca volvulus 0.0123 0.0833 0.0815
Echinococcus multilocularis dro:myosuppressin receptor 0.0123 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0051
Brugia malayi hypothetical protein 0.0123 0.0833 0.0823
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.14 0.139
Mycobacterium leprae Conserved hypothetical protein 0.002 0.0048 0.0357
Trypanosoma brucei cAMP binding protein, putative 0.0028 0.0111 0.0351
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Brugia malayi hypothetical protein 0.0123 0.0833 0.0823
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0026 0.0044
Brugia malayi Dopamine receptor 0.0123 0.0833 0.0823
Trypanosoma brucei cytochrome P450, putative 0.002 0.0048 0.0105
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0224 0.1611 0.1611
Leishmania major protein kinase, putative 0.0028 0.0111 0.0351
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0036 0.0036
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0184 0.0158
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.004 0.0204 0.0179
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Echinococcus multilocularis rhodopsin orphan GPCR 0.0123 0.0833 0.0833
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0028 0.0111 0.0086
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0028 0.0111 0.0479
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0017 0.0026 0.0044
Mycobacterium ulcerans transcriptional regulatory protein 0.0028 0.0111 0.2007
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0051 0.0051
Echinococcus granulosus single minded 2 0.0017 0.0026 0.0026
Echinococcus multilocularis geminin 0.0165 0.1157 0.1157
Brugia malayi cytochrome P450 0.002 0.0048 0.0036
Echinococcus granulosus intermediate filament protein 0.0028 0.0111 0.0111
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0088 0.0088
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0366 0.0341
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0123 0.0833 0.081
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0026 0.0044
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.004 0.0204 0.0204
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0026 0.0044
Loa Loa (eye worm) hypothetical protein 0.0038 0.0184 0.0184
Echinococcus multilocularis g protein coupled receptor 0.0123 0.0833 0.0833
Onchocerca volvulus 0.0224 0.1611 0.1594
Brugia malayi beta-lactamase family protein 0.0038 0.0184 0.0172
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0224 0.1611 0.1611
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0123 0.0833 0.0833
Echinococcus granulosus g protein coupled receptor 0.0123 0.0833 0.0833
Echinococcus multilocularis g-protein coupled receptor 0.0123 0.0833 0.0833
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0184 0.1334
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0028 0.0111 0.0086
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0123 0.0833 0.0833
Leishmania major hypothetical protein, conserved 0.0028 0.0111 0.0351
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0088 0.0088
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0184 0.0847
Echinococcus multilocularis g protein coupled receptor 0.0123 0.0833 0.0833
Onchocerca volvulus 0.0038 0.0184 0.0163
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.023 0.1712
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0184 0.0807
Loa Loa (eye worm) hypothetical protein 0.02 0.1426 0.1426
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0376 0.0351
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0036 0.0036
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0123 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Brugia malayi glutathione reductase 0.0038 0.0189 0.0177
Brugia malayi hypothetical protein 0.002 0.0051 0.004
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0017 0.0026 0.0044
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0036 0.006
Echinococcus granulosus cyclic nucleotide gated cation channel 0.004 0.0204 0.0204
Echinococcus multilocularis neuropeptide Y receptor 0.0123 0.0833 0.0833
Trichomonas vaginalis adenylate cyclase, putative 0.0017 0.0026 0.0044
Loa Loa (eye worm) hypothetical protein 0.1322 1 1
Echinococcus granulosus fmrfamide receptor 0.0123 0.0833 0.0833
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0026 0.0044
Echinococcus granulosus dro:myosuppressin receptor 0.0123 0.0833 0.0833
Entamoeba histolytica hypothetical protein 0.0038 0.0183 0.778
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0036 0.001
Toxoplasma gondii cytochrome p450 superfamily protein 0.002 0.0048 0.0074
Onchocerca volvulus 0.003 0.0122 0.0102
Echinococcus multilocularis rhodopsin orphan GPCR 0.0123 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0224 0.1611 0.1611
Loa Loa (eye worm) cytochrome P450 family protein 0.0081 0.0512 0.0512
Onchocerca volvulus 0.0123 0.0833 0.0815
Loa Loa (eye worm) doublecortin family protein 0.002 0.0051 0.0051
Schistosoma mansoni 60S ribosomal protein L21 0.0029 0.0119 0.0093
Loa Loa (eye worm) beta-lactamase 0.0038 0.0184 0.0184
Onchocerca volvulus 0.0123 0.0833 0.0815
Leishmania major hypothetical protein, conserved 0.0038 0.0184 0.0629
Schistosoma mansoni sodium/chloride dependent transporter 0.0224 0.1611 0.159
Plasmodium falciparum transporter, putative 0.0224 0.1611 1
Trichomonas vaginalis adenylate cyclase type III, putative 0.0017 0.0026 0.0044
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0123 0.0833 0.0833
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0026 0.0044
Onchocerca volvulus 0.0123 0.0833 0.0815
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0111 0.0086
Echinococcus multilocularis neuropeptides capa receptor 0.0123 0.0833 0.0833
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0224 0.1611 0.1602
Schistosoma mansoni hypothetical protein 0.0817 0.6139 0.6129
Plasmodium vivax amine transporter, putative 0.0224 0.1611 1
Echinococcus multilocularis serotonin receptor 0.0123 0.0833 0.0833
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0224 0.1611 0.159
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0061 0.0158
Loa Loa (eye worm) hypothetical protein 0.0525 0.3911 0.3911
Mycobacterium ulcerans transmembrane transport protein 0.0028 0.0111 0.2007
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0123 0.0833 0.0833
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0026 0.0044
Echinococcus granulosus sodium and chloride dependent glycine 0.0224 0.1611 0.1611
Echinococcus granulosus cGMP dependent protein kinase 0.0028 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0036 0.006
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0036 0.006
Brugia malayi G protein-coupled receptor 0.0123 0.0833 0.0823
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0184 0.0172
Mycobacterium tuberculosis Conserved protein 0.0028 0.0111 0.0379
Echinococcus granulosus neuropeptide receptor 0.0123 0.0833 0.0833
Schistosoma mansoni sodium-dependent amino acid transporter 0.0224 0.1611 0.159
Echinococcus multilocularis lamin 0.0028 0.0111 0.0111
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0036 0.006
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0028 0.0111 0.0086
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0028 0.0111 0.0111
Trichomonas vaginalis adenylate cyclase, putative 0.0017 0.0026 0.0044
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0026 0.0044
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0176 0.1243 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.002 0.0048 0.0105
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0036 0.006
Leishmania major protein kinase A regulatory subunit, putative 0.0028 0.0111 0.0351
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0026 0.0044
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Schistosoma mansoni intermediate filament proteins 0.0028 0.0111 0.0086
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0028 0.0111 0.0479
Brugia malayi ORL1-like opioid receptor 0.0123 0.0833 0.0823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Leishmania major hypothetical protein, conserved 0.0028 0.0111 0.0351
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0051 0.0051
Trichomonas vaginalis adenylate cyclase, putative 0.0017 0.0026 0.0044
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0026 0.0044
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0017 0.0026 0.0044
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0026 0.0044
Brugia malayi Melatonin receptor type 1A 0.0123 0.0833 0.0823
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.004 0.0204 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0026 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Schistosoma mansoni cpg binding protein 0.0031 0.0135 0.011
Mycobacterium ulcerans hypothetical protein 0.0028 0.0111 0.2007
Brugia malayi hypothetical protein 0.0123 0.0833 0.0823
Schistosoma mansoni alpha-1 adrenergic receptor 0.0123 0.0833 0.081
Trichomonas vaginalis adenylate cyclase, putative 0.0017 0.0026 0.0044
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0183 0.0183
Leishmania major hypothetical protein, conserved 0.0028 0.0111 0.0351
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0184 0.2578
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0123 0.0833 0.081
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0356 0.2615 1
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0017 0.0026 0.0044
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.14 0.14
Loa Loa (eye worm) hypothetical protein 0.0224 0.1611 0.1611
Brugia malayi hypothetical protein 0.0123 0.0833 0.0823
Loa Loa (eye worm) melatonin receptor type 1A 0.0123 0.0833 0.0833
Onchocerca volvulus 0.0038 0.0184 0.0163
Mycobacterium tuberculosis Conserved hypothetical protein 0.0028 0.0111 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0026 0.0044
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Schistosoma mansoni histamine h1 receptor 0.0123 0.0833 0.081
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0048 0.0105
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0123 0.0833 0.081
Loa Loa (eye worm) hypothetical protein 0.0224 0.1611 0.1611
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.023 0.023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Leishmania major lanosterol 14-alpha-demethylase, putative 0.002 0.0048 0.0105
Echinococcus granulosus cGMP dependent protein kinase 1 0.0028 0.0111 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0123 0.0833 0.081
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0036 0.0744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Brugia malayi putative neuropeptide receptor 0.0123 0.0833 0.0823
Toxoplasma gondii ABC1 family protein 0.0038 0.0184 0.0937
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0224 0.1611 0.159
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0184 0.1334
Echinococcus multilocularis serotonin transporter 0.1322 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0224 0.1611 0.159
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0036 0.006
Echinococcus multilocularis lamin dm0 0.0028 0.0111 0.0111
Schistosoma mansoni cpg binding protein 0.0031 0.0135 0.011
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.023 0.023
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0017 0.0026 0.0044
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0028 0.0111 0.0479
Schistosoma mansoni amine GPCR 0.0123 0.0833 0.081
Echinococcus granulosus RUN 0.002 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0038 0.0184 0.0184
Echinococcus granulosus voltage gated potassium channel 0.0057 0.0334 0.0334
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0048 0.0105
Echinococcus granulosus rhodopsin orphan GPCR 0.0123 0.0833 0.0833
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0036 0.0036
Brugia malayi hypothetical protein 0.0123 0.0833 0.0823
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0036 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Schistosoma mansoni neuropeptide f receptor 76f 0.0123 0.0833 0.081
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.0825 0.0825
Echinococcus granulosus neuropeptide FF receptor 2 0.0123 0.0833 0.0833
Leishmania major hypothetical protein, unknown function 0.0028 0.0111 0.0351
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0028 0.0111 0.0351
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0028 0.0111 0.0479
Schistosoma mansoni hypothetical protein 0.0165 0.1157 0.1134
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0028 0.0111 0.0086
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0028 0.0111 0.0379
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.0638 0.3504
Mycobacterium leprae Conserved hypothetical protein 0.0028 0.0111 0.14
Leishmania major C-8 sterol isomerase-like protein 0.0356 0.2615 1
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0028 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Echinococcus granulosus g protein coupled receptor 0.0123 0.0833 0.0833
Leishmania major cytochrome p450-like protein 0.002 0.0048 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0224 0.1611 0.1611
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Schistosoma mansoni neuropeptide receptor 0.0123 0.0833 0.081
Echinococcus granulosus neuropeptide Y receptor 0.0123 0.0833 0.0833
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0028 0.0111 0.0086
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.14 0.14
Echinococcus granulosus cGMP dependent protein kinase 1 0.0028 0.0111 0.0111
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0184 0.4273
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Toxoplasma gondii thioredoxin reductase 0.0038 0.0189 0.0969
Schistosoma mansoni neuropeptide F-like receptor 0.0123 0.0833 0.081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0123 0.0833 0.081
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0123 0.0833 0.0833
Schistosoma mansoni hypothetical protein 0.002 0.0048 0.0022
Onchocerca volvulus 0.0123 0.0833 0.0815
Echinococcus granulosus neuropeptide s receptor 0.0678 0.508 0.508
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0026 0.0044
Schistosoma mansoni rab6-interacting 0.002 0.0051 0.0026
Echinococcus multilocularis hyperpolarization activated cyclic 0.004 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Echinococcus granulosus rhodopsin orphan GPCR 0.0123 0.0833 0.0833
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0028 0.0111 0.0385
Schistosoma mansoni hypothetical protein 0.0123 0.0833 0.081
Trichomonas vaginalis adenylate cyclase type III, putative 0.0017 0.0026 0.0044
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0026 0.0044
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.023 0.1712
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Echinococcus multilocularis neuropeptide s receptor 0.0678 0.508 0.508
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0028 0.0111 0.0385
Onchocerca volvulus 0.0123 0.0833 0.0815
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0123 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0028 0.0111 0.0111
Echinococcus multilocularis expressed conserved protein 0.0028 0.0111 0.0111
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0184 0.1334
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0051
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.004 0.0204 0.0204
Echinococcus multilocularis allatostatin A receptor 0.0123 0.0833 0.0833
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Schistosoma mansoni adenoreceptor 0.0123 0.0833 0.081
Mycobacterium leprae putative cytochrome p450 0.002 0.0048 0.0357
Loa Loa (eye worm) hypothetical protein 0.0028 0.0107 0.0107
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.004 0.0204 0.0204
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0028 0.0111 0.0745
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0036 0.001
Echinococcus granulosus serotonin transporter 0.1322 1 1
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0028 0.0111 0.0086
Onchocerca volvulus 0.0123 0.0833 0.0815
Echinococcus granulosus G protein coupled receptor 139 0.0123 0.0833 0.0833
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0028 0.0111 0.0086
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0057 0.0334 0.0323
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.023 0.1712
Mycobacterium ulcerans hypothetical protein 0.0038 0.0184 0.4273
Trypanosoma cruzi cAMP binding protein, putative 0.0028 0.0111 0.0351
Schistosoma mansoni hypothetical protein 0.0123 0.0833 0.081
Loa Loa (eye worm) hypothetical protein 0.0028 0.0111 0.0111
Schistosoma mansoni amine GPCR 0.0123 0.0833 0.081
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0028 0.0111 0.0379
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0224 0.1611 0.1602
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0224 0.1611 0.1611
Brugia malayi G-protein coupled receptor 0.0123 0.0833 0.0823
Echinococcus granulosus biogenic amine 5HT receptor 0.0123 0.0833 0.0833
Leishmania major trypanothione reductase 0.0038 0.0189 0.0648
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0026 0.0044
Trichomonas vaginalis guanylate cyclase, putative 0.0017 0.0026 0.0044
Brugia malayi Tachykinin-like peptides receptor 99D 0.0123 0.0833 0.0823
Echinococcus multilocularis fmrfamide receptor 0.0123 0.0833 0.0833
Schistosoma mansoni alpha-glucosidase 0.0169 0.1191 0.1168
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0051 0.0051
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.023 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0036 0.0127
Trichomonas vaginalis adenylate cyclase, putative 0.0017 0.0026 0.0044
Schistosoma mansoni alpha-glucosidase 0.0169 0.1191 0.1168
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0184 0.0807
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0184 0.0807
Loa Loa (eye worm) hypothetical protein 0.0123 0.0833 0.0833
Trichomonas vaginalis adenylate cyclase type, putative 0.0017 0.0026 0.0044
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0224 0.1611 0.159
Onchocerca volvulus 0.0224 0.1611 0.1594
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0123 0.0833 0.0833
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0123 0.0833 0.081
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0026 0.0044
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0193 0.0193
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0123 0.0833 0.0823
Schistosoma mansoni voltage-gated potassium channel 0.0205 0.1466 0.1444
Echinococcus granulosus allatostatin A receptor 0.0123 0.0833 0.0833
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.0563 0.3062
Trichomonas vaginalis hypothetical protein 0.0017 0.0026 0.0044
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0184 0.0629
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.023 0.1712
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0017 0.0026 0.0044
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0123 0.0833 0.0833
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0123 0.0833 0.081
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.1733 1
Onchocerca volvulus 0.0123 0.0833 0.0815
Brugia malayi hypothetical protein 0.0123 0.0833 0.0823
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.023 0.0807
Schistosoma mansoni voltage-gated potassium channel 0.0057 0.0334 0.0309
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0224 0.1611 1

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 0.316227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 8.912509381 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 14.12537545 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.0175 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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