Detailed information for compound 1460440

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 300.309 | Formula: C16H16N2O4
  • H donors: 4 H acceptors: 5 LogP: 2.74 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1c(O)nc2c(c1O)CCCC2)Nc1ccccc1O
  • InChi: 1S/C16H16N2O4/c19-12-8-4-3-7-11(12)18-16(22)13-14(20)9-5-1-2-6-10(9)17-15(13)21/h3-4,7-8,19H,1-2,5-6H2,(H,18,22)(H2,17,20,21)
  • InChiKey: IPNKQEXEZCHFKE-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens X-box binding protein 1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Mus musculus DNA-damage inducible transcript 3 Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134980 All targets in OG5_134980
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus X box binding protein 1 Get druggable targets OG5_134980 All targets in OG5_134980
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum IPR011700,Basic leucine zipper;IPR004827,Basic-leucine zipper (bZIP) transcription factor;IPR008917,Eukaryotic transcription fac Get druggable targets OG5_134980 All targets in OG5_134980
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis X box binding protein 1 Get druggable targets OG5_134980 All targets in OG5_134980
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum IPR011700,Basic leucine zipper;IPR004827,Basic-leucine zipper (bZIP) transcription factor;IPR008917,Eukaryotic transcription fac Get druggable targets OG5_134980 All targets in OG5_134980
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.002 0.0064 0.034
Leishmania major hypothetical protein, conserved 0.003 0.0137 0.0482
Onchocerca volvulus 0.0058 0.0324 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0066 0.0356
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0126 0.078 0.1407
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0275 0.1547
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0124 0.0215
Schistosoma mansoni phosphatidylserine receptor 0.0029 0.0127 0.0229
Brugia malayi RNA binding protein 0.0135 0.0843 0.275
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0189 0.1201 0.2167
Loa Loa (eye worm) hypothetical protein 0.0097 0.0588 0.0583
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0014 0.0025
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0041 0.0205 0.0361
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0265 0.026
Giardia lamblia DNA repair protein RAD52 0.0383 0.2509 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0085 0.0366
Schistosoma mansoni jumonji/arid domain-containing protein 0.0114 0.0697 0.1257
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0125 0.1092
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0173 0.0312
Leishmania major heat shock protein 83-1 0.0047 0.0251 0.0983
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0304 0.0458
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1076 0.1933
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.002 0.0064 0.0115
Plasmodium vivax farnesyltransferase beta subunit, putative 0.002 0.0064 0.0248
Echinococcus granulosus endoplasmin 0.0045 0.0231 0.0409
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0014 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0009
Onchocerca volvulus 0.0271 0.1758 0.1753
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0064 0.0162
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0173 0.1516
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1855 0.2836
Schistosoma mansoni endoplasmin 0.0047 0.0251 0.0453
Brugia malayi jmjC domain containing protein 0.0029 0.0127 0.0413
Echinococcus granulosus microtubule associated protein 2 0.0833 0.5544 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0047 0.0251 0.0982
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0239 0.183
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.02 0.1278 0.5539
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0251 0.0983
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0014 0.0009
Trypanosoma cruzi phospholipase A1, putative 0.0353 0.2308 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0124 0.0406
Loa Loa (eye worm) hypothetical protein 0.005 0.0265 0.026
Brugia malayi PHD-finger family protein 0.0015 0.0034 0.0111
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0014 0.0008
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0014 0.0013
Echinococcus granulosus snurportin 1 0.0306 0.1993 0.359
Echinococcus granulosus geminin 0.0362 0.2369 0.4269
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0156 0.0231
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0156 0.0508
Trypanosoma cruzi heat shock protein, putative 0.0032 0.0144 0.0513
Loa Loa (eye worm) CXXC zinc finger family protein 0.0088 0.0526 0.0521
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0014 0.0008
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.0987 0.3219
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0014 0.0016
Schistosoma mansoni ran 0.0021 0.0074 0.0133
Echinococcus granulosus heat shock protein 90 0.0041 0.0205 0.0361
Leishmania major heat shock protein 83-1 0.0047 0.0251 0.0983
Giardia lamblia Grp94/Hsp90 0.0045 0.0231 0.0904
Entamoeba histolytica hypothetical protein 0.0043 0.0224 0.0887
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0059
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0124 0.313
Loa Loa (eye worm) hypothetical protein 0.0157 0.0987 0.0982
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0173 0.0312
Trypanosoma cruzi heat shock protein 90, putative 0.0041 0.0205 0.0781
Leishmania major heat shock protein 83-1 0.0047 0.0251 0.0983
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0156 0.0231
Echinococcus multilocularis protocadherin 11 0.0011 0.0006 0.0001
Onchocerca volvulus Alhambra homolog 0.0031 0.0141 0.0135
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0085 0.0726
Leishmania major heat shock protein 83-1 0.0047 0.0251 0.0983
Loa Loa (eye worm) hypothetical protein 0.0072 0.0418 0.0413
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0224 0.0396
Trichomonas vaginalis helicase, putative 0.002 0.0066 0.0356
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0162 0.1021 0.436
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0066 0.0356
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0029 0.0127 0.0229
Brugia malayi Bromodomain containing protein 0.0035 0.0166 0.0543
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0088 0.027
Plasmodium vivax importin-beta 2, putative 0.0029 0.0125 0.08
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0156 0.1364
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.002 0.0064 0.034
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0049 0.0262 0.1033
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0745 0.1343
Brugia malayi Ceramide glucosyltransferase 0.0234 0.1505 0.4908
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0014 0.0009
Schistosoma mansoni hypothetical protein 0.005 0.0265 0.0479
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0156 0.0566
Schistosoma mansoni cpg binding protein 0.0088 0.0526 0.0949
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0364 0.0359
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0124 0.0428
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0732 0.2913
Schistosoma mansoni jumonji/arid domain-containing protein 0.0114 0.0697 0.1257
Toxoplasma gondii exonuclease III APE 0.0023 0.0085 0.074
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0066 0.0356
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0127 0.0122
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.002 0.0064 0.009
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0124 0.0406
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0125 0.054
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.0653 0.213
Schistosoma mansoni hypothetical protein 0.0306 0.1993 0.3595
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0009
Echinococcus multilocularis snurportin 1 0.0306 0.1993 0.3049
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0275 0.0488
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.0251 0.1088
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0213 0.083
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0124 0.313
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0029 0.0127 0.0549
Brugia malayi Cytochrome P450 family protein 0.003 0.0132 0.043
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0074 0.0105
Brugia malayi Latrophilin receptor protein 2 0.005 0.0265 0.0866
Echinococcus granulosus lysine specific demethylase 5A 0.0114 0.0697 0.1249
Plasmodium falciparum cysteine protease ATG4, putative 0.0049 0.0262 0.2286
Onchocerca volvulus Phospholipase A2 homolog 0.0392 0.257 0.2566
Schistosoma mansoni hypothetical protein 0.0049 0.0263 0.0474
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0034 0.0161 0.0238
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0014 0.0009
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0014 0.0045
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.02 0.1278 0.5486
Brugia malayi isocitrate dehydrogenase 0.0033 0.0156 0.0508
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0014 0.0025
Entamoeba histolytica peptidase, C54 family 0.0049 0.0262 0.104
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.0011
Echinococcus granulosus ccaat enhancer binding protein delta 0.0011 0.0006 0.0001
Entamoeba histolytica peptidase, C54 family 0.0049 0.0262 0.104
Brugia malayi hypothetical protein 0.003 0.0137 0.0446
Trypanosoma brucei phospholipase A1, putative 0.0353 0.2308 1
Brugia malayi Pre-SET motif family protein 0.0036 0.0173 0.0565
Loa Loa (eye worm) TAR-binding protein 0.0135 0.0843 0.0838
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0141 0.1233
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0014 0.0013
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.5544 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0014 0.0009
Echinococcus multilocularis protein dispatched 1 0.0058 0.0324 0.0489
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0156 0.0231
Schistosoma mansoni hypothetical protein 0.005 0.0265 0.0479
Schistosoma mansoni phd/f-box containing protein 0.0029 0.0127 0.0229
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0074 0.0124
Leishmania major GTP-binding protein, putative 0.0021 0.0074 0.0206
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0014 0.0013
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0251 0.0983
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0033 0.0156 0.0282
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0127 0.0438
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0014 0.0025
Giardia lamblia Hypothetical protein 0.0011 0.0006 0.0003
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0124 0.0119
Echinococcus granulosus histone acetyltransferase KAT2B 0.0151 0.0946 0.1699
Trypanosoma brucei lanosterol synthase 0.0347 0.2269 0.9832
Leishmania major sterol 24-c-methyltransferase, putative 0.02 0.1278 0.5486
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0071
Schistosoma mansoni autophagin-1 (C54 family) 0.0126 0.078 0.1407
Schistosoma mansoni hypothetical protein 0.0031 0.0141 0.0254
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0173 0.0312
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0156 0.1364
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0125 0.0183
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.002 0.0064 0.034
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.002 0.0064 0.0557
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0045 0.0231 1
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0137 0.0908
Echinococcus multilocularis cyclic AMP responsive element binding protein 0.0011 0.0006 0.0001
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0032 0.0144 0.0213
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.002 0.0064 0.0208
Plasmodium falciparum endoplasmin, putative 0.0034 0.0163 0.1418
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0156 0.0675
Brugia malayi PHD-finger family protein 0.0031 0.0141 0.0459
Schistosoma mansoni hypothetical protein 0.0049 0.0263 0.0474
Toxoplasma gondii heat shock protein 90, putative 0.0047 0.0251 0.2198
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0001
Brugia malayi Pre-SET motif family protein 0.0238 0.1538 0.5016
Schistosoma mansoni cpg binding protein 0.0093 0.056 0.101
Leishmania major heat shock protein 83-1 0.0047 0.0251 0.0983
Plasmodium falciparum heat shock protein 90 0.0047 0.0251 0.2186
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0173 0.1095 0.1968
Echinococcus granulosus bloom syndrome protein 0.0026 0.011 0.0189
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0275 0.027
Echinococcus multilocularis jumonji domain containing 1A 0.0029 0.0127 0.0186
Entamoeba histolytica hypothetical protein 0.0023 0.0088 0.0345
Brugia malayi steroid hormone receptor 0.0012 0.0014 0.0045
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.002 0.0064 0.034
Loa Loa (eye worm) hypothetical protein 0.0036 0.0173 0.0168
Schistosoma mansoni cpg binding protein 0.0093 0.056 0.101
Brugia malayi Importin beta-1 subunit 0.0029 0.0125 0.0407
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0124 0.313
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0124 0.313
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0126 0.078 0.4425
Echinococcus multilocularis lysine specific demethylase 6a 0.0029 0.0127 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0066 0.0356
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0124 0.0406
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0124 0.0182
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0085 0.008
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.002 0.0064 0.0115
Echinococcus multilocularis peregrin 0.0035 0.0166 0.0247
Schistosoma mansoni hypothetical protein 0.0014 0.0024 0.0043
Schistosoma mansoni survival motor neuron protein 0.0058 0.0324 0.0584
Echinococcus multilocularis lysine specific demethylase 5A 0.0109 0.0663 0.1009
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.002 0.0064 0.0059
Trichomonas vaginalis heat shock protein, putative 0.0047 0.0251 0.1409
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0074 0.032
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0085 0.0254
Leishmania major heat shock protein 83-1 0.0047 0.0251 0.0983
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0126 0.078 0.3302
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0137 0.1182
Entamoeba histolytica hypothetical protein 0.0043 0.0224 0.0887
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.002 0.0064 0.0557
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0126 0.078 0.1407
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0014 0.0045
Echinococcus multilocularis protein patched 0.0051 0.0275 0.0414
Schistosoma mansoni endoplasmin 0.0047 0.0251 0.0453
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0088 0.0481
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.002 0.0064 0.0247
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0045 0.0231 1
Brugia malayi bZIP transcription factor family protein 0.0011 0.0006 0.0019
Schistosoma mansoni par domain protein 0.0011 0.0006 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0066 0.0356
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0059
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0126 0.078 0.4425
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0001
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0306 0.1993 0.1989
Entamoeba histolytica Ran family GTPase 0.0021 0.0074 0.0287
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0239 0.2089
Plasmodium falciparum heat shock protein 90, putative 0.0028 0.0117 0.1013
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6526 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0029 0.0127 0.1109
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0155 0.0976 0.1488
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0011 0.0006 0.0001
Plasmodium vivax SET domain protein, putative 0.0036 0.0173 0.1237
Trypanosoma brucei heat shock protein, putative 0.0047 0.0251 0.1088
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0014 0.0045
Mycobacterium ulcerans hypothetical protein 0.0029 0.0124 0.313
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0014 0.0025
Treponema pallidum heat shock protein 90 0.0045 0.0231 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0014 0.0025
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0029 0.0127 0.1109
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1855 0.334
Schistosoma mansoni heat shock protein 0.0047 0.0251 0.0453
Brugia malayi Cell death specification protein 2 0.0011 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.0062 0.0353 0.0348
Echinococcus multilocularis geminin 0.0362 0.2369 0.3625
Echinococcus granulosus tar DNA binding protein 0.0135 0.0843 0.1513
Trypanosoma cruzi protein farnesyltransferase, putative 0.002 0.0064 0.0162
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.0987 0.3219
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0066 0.0356
Leishmania major importin beta-1 subunit, putative 0.0023 0.0088 0.027
Brugia malayi Cell death specification protein 2 0.0011 0.0006 0.0019
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0085 0.033
Giardia lamblia PHD finger protein 15 0.0031 0.0141 0.0542
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0141 0.1233
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0014 0.0025
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0065 0.0169
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0076 0.5
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0843 0.152
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0156 0.0566
Echinococcus multilocularis cysteine protease atg4b 0.0126 0.078 0.1188
Schistosoma mansoni hypothetical protein 0.0049 0.0263 0.0474
Brugia malayi ecdysteroid receptor 0.0012 0.0014 0.0045
Schistosoma mansoni vesicular acetylcholine transporter 0.0465 0.3065 0.5529
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0014 0.0016
Echinococcus granulosus cpg binding protein 0.0093 0.056 0.1002
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.002 0.0064 0.034
Echinococcus multilocularis cpg binding protein 0.0093 0.056 0.0851
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0071
Echinococcus granulosus GPCR family 2 0.005 0.0265 0.047
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.02 0.1278 0.5539
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.0843 0.0838
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0005 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0173 0.0312
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0051 0.0443
Trypanosoma brucei Heat shock protein 83, putative 0.0047 0.0251 0.1088
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.002 0.0064 0.0557
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.002 0.0064 0.034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0014 0.0045
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.002 0.0064 0.034
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0014 0.0025
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0251 0.0983
Brugia malayi nuclear hormone receptor 0.0012 0.0014 0.0045
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0224 0.0404
Leishmania major heat shock protein 83-1 0.0047 0.0251 0.0983
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0009
Echinococcus granulosus ceramide glucosyltransferase 0.0234 0.1505 0.2707
Entamoeba histolytica hypothetical protein 0.0043 0.0224 0.0887
Schistosoma mansoni hypothetical protein 0.0043 0.0224 0.0404
Brugia malayi hypothetical protein 0.0043 0.0224 0.0731
Echinococcus multilocularis ceramide glucosyltransferase 0.0234 0.1505 0.2299
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0009
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.002 0.0064 0.034
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0085 0.0276
Plasmodium falciparum phd finger protein, putative 0.0031 0.0141 0.1219
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0239 0.1338
Echinococcus multilocularis tar DNA binding protein 0.0135 0.0843 0.1285
Trypanosoma cruzi lanosterol synthase, putative 0.0347 0.2269 0.983
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0124 0.313
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0213 0.1853
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.002 0.0064 0.0162
Brugia malayi hypothetical protein 0.0286 0.1855 0.6051
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0156 0.0231
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0074 0.0241
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0027 0.0099
Echinococcus multilocularis heat shock protein 90 0.0041 0.0205 0.0306
Schistosoma mansoni thyrotroph embryonic factor related 0.0011 0.0006 0.0011
Loa Loa (eye worm) RNA binding protein 0.0135 0.0843 0.0838
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0085 0.046
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.3258 0.4988
Onchocerca volvulus 0.0036 0.0173 0.0167
Trypanosoma brucei Sterol methyltransferase, putative 0.02 0.1278 0.5539
Loa Loa (eye worm) platelet-activating factor acetylhydrolase 0.0353 0.2308 0.2304
Loa Loa (eye worm) hypothetical protein 0.0107 0.0653 0.0648
Giardia lamblia Heat shock protein HSP 90-alpha 0.0041 0.0205 0.0798
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.002 0.0064 0.0208
Schistosoma mansoni hypothetical protein 0.0362 0.2369 0.4274
Trichomonas vaginalis heat shock protein, putative 0.0041 0.0205 0.1146
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0014 0.0045
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0074 0.0274
Schistosoma mansoni heat shock protein 0.0047 0.0251 0.0453
Leishmania major farnesyltransferase beta subunit 0.002 0.0064 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0014 0.0045
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0163 0.091
Onchocerca volvulus 0.0353 0.2308 0.2303
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0014 0.0045
Brugia malayi heat shock protein 90 0.0047 0.0251 0.0819
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0088 0.0481
Trypanosoma cruzi Heat shock protein 83, putative 0.0047 0.0251 0.0983
Echinococcus granulosus transcriptional factor nfil3:e4bp4 0.0011 0.0006 0.0001
Plasmodium falciparum geranylgeranyltransferase, putative 0.002 0.0064 0.0542
Leishmania major heat shock protein 83-1 0.0047 0.0251 0.0983
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0066 0.0356
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0027 0.013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0009
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0152 0.0265
Brugia malayi hypothetical protein 0.0011 0.0006 0.0019
Echinococcus granulosus protocadherin 11 0.0011 0.0006 0.0001
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0162 0.1021 0.436
Echinococcus granulosus protein farnesyltransferase subunit beta 0.002 0.0064 0.0106
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0032 0.0144 0.025
Entamoeba histolytica peptidase, C54 family 0.0126 0.078 0.3104
Brugia malayi S-adenosyl-methionine cycloartenol-C24-methyltransferase 0.0097 0.0588 0.1918
Echinococcus granulosus peregrin 0.0035 0.0166 0.0291
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0064 0.0162
Brugia malayi Phospholipase A2 family protein 0.0392 0.257 0.8386
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0124 0.0428
Trypanosoma brucei heat shock protein, putative 0.0047 0.0251 0.1088
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0005 0.0045
Schistosoma mansoni patched 1 0.0051 0.0275 0.0496
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0155 0.0976 0.176
Loa Loa (eye worm) heat shock protein 90 0.0047 0.0251 0.0246
Onchocerca volvulus 0.0012 0.0014 0.0008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0029
Trypanosoma cruzi heat shock protein 90, putative 0.0047 0.0251 0.0983
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0126 0.078 0.3302
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0066 0.0356
Schistosoma mansoni myst-related protein 0.001 0.0002 0.0003
Trypanosoma cruzi protein farnesyltransferase, putative 0.002 0.0064 0.0162
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0124 0.0428
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.002 0.0064 0.0247
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0032 0.0144 0.0566
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0141 0.0946
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0014 0.0008
Echinococcus multilocularis heat shock protein 0.0047 0.0251 0.0377
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0014 0.0009
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.011 0.0603
Trichomonas vaginalis ran, putative 0.0021 0.0074 0.0398
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0009
Loa Loa (eye worm) hypothetical protein 0.0051 0.0275 0.027
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0119
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0009
Echinococcus granulosus JmjC domain containing protein 4 0.0029 0.0127 0.022
Loa Loa (eye worm) hypothetical protein 0.0029 0.0127 0.0122
Brugia malayi CXXC zinc finger family protein 0.0088 0.0526 0.1717
Leishmania major phospholipase A1, putative 0.0353 0.2308 1
Brugia malayi TAR-binding protein 0.0135 0.0843 0.275
Schistosoma mansoni DNA helicase recq1 0.0011 0.0005 0.0009
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.02 0.1278 0.5486
Schistosoma mansoni importin beta-1 0.0029 0.0125 0.0225
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0014 0.0013
Entamoeba histolytica hypothetical protein 0.0043 0.0224 0.0887
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0126 0.078 0.338
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0014 0.0016
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0014 0.0025
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0141 0.0136
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.0987 0.0982
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0014 0.0045
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0173 0.0258
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0843 0.152
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0126 0.078 0.4425
Plasmodium vivax endoplasmin, putative 0.0047 0.0251 0.1942
Giardia lamblia Prenyltransferase 0.002 0.0064 0.0234
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0074 0.0206
Loa Loa (eye worm) hypothetical protein 0.0286 0.1855 0.1851
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0156 0.0281
Echinococcus granulosus expressed conserved protein 0.0112 0.0684 0.1225
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0137 0.0482
Echinococcus multilocularis heat shock protein 90 0.0047 0.0251 0.0377
Toxoplasma gondii Hsp90 domain-containing protein 0.018 0.1142 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0126 0.078 0.0775
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0304 0.0299
Trypanosoma brucei protein farnesyltransferase beta subunit 0.002 0.0064 0.0276
Plasmodium vivax heat shock protein, putative 0.018 0.1142 1
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.002 0.0064 0.009
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0066 0.0356
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0034 0.0161 0.0281
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0119
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.002 0.0064 0.0106
Trypanosoma brucei heat shock protein, putative 0.0047 0.0251 0.1088
Echinococcus granulosus lysine specific demethylase 6a 0.0029 0.0127 0.022
Echinococcus multilocularis Peptidase C54 0.0126 0.078 0.1188
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0066 0.0356
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0001
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0156 0.0672
Leishmania major heat shock protein 83-1 0.0047 0.0251 0.0983
Leishmania major sterol 24-c-methyltransferase, putative 0.02 0.1278 0.5486
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0016 0.0036 0.0302
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0903 0.0898
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0126 0.078 0.4425
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0014 0.0025
Schistosoma mansoni hypothetical protein 0.005 0.0265 0.0479
Trypanosoma cruzi heat shock protein 85, putative 0.0041 0.0205 0.0781
Schistosoma mansoni hypothetical protein 0.005 0.0265 0.0479
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0009
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0304 0.0991
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0088 0.0756
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0014 0.0025
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0001
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0124 0.313
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0014 0.0016
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.0251 0.1088
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0275 0.0488
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0014 0.0013
Brugia malayi jmjC domain containing protein 0.0029 0.0127 0.0413
Brugia malayi hypothetical protein 0.002 0.0064 0.0209
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0124 0.0489
Echinococcus multilocularis JmjC domain containing protein 4 0.0029 0.0127 0.0186
Echinococcus granulosus cysteine protease atg4b 0.0126 0.078 0.1399
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0071
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0014 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0125 0.012
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0213 0.0843
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0066 0.0356
Echinococcus granulosus heat shock protein 90 0.0047 0.0251 0.0444
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0843 0.152
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0076 0.006
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0173 0.1095 0.1671
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0156 0.1351
Brugia malayi Endoplasmin precursor 0.0047 0.0251 0.0819
Brugia malayi Peptidase family C54 containing protein 0.0126 0.078 0.2545
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.002 0.0064 0.0276
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0132 0.0127
Schistosoma mansoni heat shock protein 0.0032 0.0144 0.0259
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0085 0.0122
Schistosoma mansoni ap endonuclease 0.0023 0.0085 0.0153
Leishmania major heat shock protein, putative 0.0032 0.0144 0.0513
Brugia malayi jmjC domain containing protein 0.0114 0.0697 0.2274
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0014 0.0016
Leishmania major heat shock protein 83-1 0.0047 0.0251 0.0983
Leishmania major heat shock protein 83-1 0.0047 0.0251 0.0983
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0304 0.0458
Echinococcus multilocularis bloom syndrome protein 0.0026 0.011 0.016
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.5544 0.8493
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.0127 0.1095
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.011 0.0603
Trichomonas vaginalis endoplasmin, putative 0.0034 0.0163 0.091
Leishmania major geranylgeranyltransferase, putative 0.002 0.0064 0.0162
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0231 0.1297
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0124 0.0432
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0224 0.0336
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0156 0.0151
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0239 0.1338
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0238 0.1538 0.1533
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0843 0.152
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0011 0.0006 0.0001
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0088 0.0481
Loa Loa (eye worm) acetyltransferase 0.0155 0.0976 0.0971
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0027 0.0116
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0215 0.1378 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0265 0.047
Brugia malayi jmjC domain containing protein 0.0029 0.0127 0.0413
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0032 0.0144 0.0138
Schistosoma mansoni ran 0.0021 0.0074 0.0133
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0231 0.1297
Schistosoma mansoni ceramide glucosyltransferase 0.0234 0.1505 0.2714
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0304 0.0548
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0014 0.0016
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0265 0.0399
Toxoplasma gondii heat shock protein HSP90 0.0047 0.0251 0.2198
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0104 0.0634 0.2747
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0085 0.0254
Trypanosoma brucei heat shock protein 84, putative 0.0032 0.0144 0.0623
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0383 0.2509 1
Loa Loa (eye worm) hypothetical protein 0.0392 0.257 0.2567
Echinococcus multilocularis expressed conserved protein 0.0112 0.0684 0.1041
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0088 0.0127
Brugia malayi MH2 domain containing protein 0.0144 0.0903 0.2944
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0265 0.0399
Entamoeba histolytica hypothetical protein 0.0011 0.0006 0.0016
Schistosoma mansoni myst-related protein 0.001 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0031 0.0141 0.0136
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0141 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0014 0.0045
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0005 0.0017
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0085 0.046
Toxoplasma gondii histone lysine methyltransferase SET1 0.0172 0.1092 0.9561
Loa Loa (eye worm) hypothetical protein 0.003 0.0137 0.0132
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0049 0.0262 0.1033
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.011 0.0358
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0049 0.0262 0.2298
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.002 0.0064 0.0248
Echinococcus multilocularis phd:f box containing protein 0.0029 0.0127 0.0186
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0304 0.0539
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0088 0.0127
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0074 0.0206
Schistosoma mansoni jumonji domain containing protein 0.0152 0.0954 0.1721
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0014 0.0009
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0465 0.3065 0.3061
Plasmodium falciparum importin beta, putative 0.0029 0.0125 0.1078
Leishmania major lanosterol synthase, putative 0.0327 0.2137 0.9251
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0066 0.0356
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0732 0.2389
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0085 0.057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0304 0.0548
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.002 0.0064 0.0115
Brugia malayi Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein 0.0353 0.2308 0.7529
Brugia malayi hypothetical protein 0.0011 0.0006 0.0019
Brugia malayi nuclear receptor NHR-88 0.0012 0.0014 0.0045
Echinococcus granulosus heat shock protein 0.0047 0.0251 0.0444
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.0011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0066 0.0356
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0085 0.0143
Echinococcus multilocularis transcriptional factor nfil3:e4bp4 0.0011 0.0006 0.0001
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0732 0.1313
Trichomonas vaginalis set domain proteins, putative 0.0271 0.1758 1
Onchocerca volvulus 0.0353 0.2308 0.2303
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0074 0.0069
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0124 0.0432
Onchocerca volvulus 0.0088 0.0526 0.0521
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0223 0.0334
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0156 0.1081
Echinococcus multilocularis vesicular acetylcholine transporter 0.0465 0.3065 0.4693
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0137 0.1182
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0066 0.0356
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0085 0.0317
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0001
Entamoeba histolytica peptidase, C54 family 0.0049 0.0262 0.104
Brugia malayi RNA, U transporter 1 0.0082 0.0481 0.1569
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0126 0.078 0.4425
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0076 0.0648
Schistosoma mansoni ceramide glucosyltransferase 0.0234 0.1505 0.2714
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0071
Schistosoma mansoni ap endonuclease 0.0023 0.0085 0.0153
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.002 0.0064 0.0208
Trypanosoma cruzi phospholipase A1, putative 0.0353 0.2308 1
Leishmania major heat shock protein 83-1 0.0047 0.0251 0.0983
Schistosoma mansoni protein phosphatase 2C 0.0029 0.0127 0.0229
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0066 0.0356
Loa Loa (eye worm) hypothetical protein 0.0029 0.0124 0.0119
Brugia malayi acetyltransferase, GNAT family protein 0.0155 0.0976 0.3183
Echinococcus multilocularis X box binding protein 1 0.0348 0.2275 0.348
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0156 0.0675
Schistosoma mansoni jumonji domain containing protein 0.0029 0.0127 0.0229
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0085 0.0128
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0239 0.0422
Brugia malayi Hepatic leukemia factor 0.0011 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.0029 0.0127 0.0122
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0903 0.0898
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0088 0.0149
Brugia malayi F/Y-rich N-terminus family protein 0.0038 0.019 0.062
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0732 0.1115
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0127 0.0438
Echinococcus granulosus Peptidase C54 0.0126 0.078 0.1399
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0045 0.0231 0.0897
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0014 0.0013
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0173 0.0258
Loa Loa (eye worm) cell death specification protein 2 0.0011 0.0006 0.0001
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.002 0.0064 0.009
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0011 0.0006 0.0001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0124 0.313
Echinococcus granulosus protocadherin 11 0.0011 0.0006 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0843 0.152
Echinococcus granulosus phd:f box containing protein 0.0029 0.0127 0.022
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0137 0.1196
Schistosoma mansoni hypothetical protein 0.0107 0.0653 0.1178
Brugia malayi CHE-14 protein 0.0051 0.0275 0.0898
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0014 0.0045
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0133 0.0828 0.0823
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0074 0.0339
Leishmania major heat shock protein 83-1 0.0047 0.0251 0.0983
Brugia malayi vesicular acetylcholine transporter unc-17 0.0465 0.3065 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0014 0.0009
Echinococcus granulosus importin subunit beta 1 0.0029 0.0125 0.0216
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0014 0.0045
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0085 0.0437
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.002 0.0064 0.0059
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.002 0.0064 0.034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0304 0.0548
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0014 0.0013
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0014 0.0013
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.02 0.1278 0.5486
Leishmania major hypothetical protein, conserved 0.0029 0.0127 0.0438
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0324 0.1057
Loa Loa (eye worm) ceramide glucosyltransferase 0.0234 0.1505 0.15
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0124 0.0489
Schistosoma mansoni hypothetical protein 0.0348 0.2275 0.4103
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0024 0.0028
Loa Loa (eye worm) jmjC domain-containing protein 0.0114 0.0697 0.0692
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0004 0.00000000017276
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0011 0.0006 0.0001
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0072 0.013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0014 0.0016
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0005 0.0029
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0127 0.0122
Trypanosoma brucei heat shock protein, putative 0.0047 0.0251 0.1088
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.0251 0.0994
Echinococcus granulosus X box binding protein 1 0.0348 0.2275 0.4098
Echinococcus multilocularis ccaat enhancer binding protein delta ccaat enhancer binding protein beta 0.0011 0.0006 0.0001
Trypanosoma brucei heat shock protein, putative 0.0047 0.0251 0.1088
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0014 0.0045
Giardia lamblia Ceramide glucosyltransferase 0.0106 0.0645 0.2554
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0014 0.0013
Loa Loa (eye worm) bZIP transcription factor family protein 0.0011 0.0006 0.0001
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0109 0.0665 0.2645
Echinococcus granulosus dnaJ subfamily B 0.0494 0.3258 0.5873
Trypanosoma brucei heat shock protein, putative 0.0047 0.0251 0.1088
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0239 0.2089
Plasmodium falciparum heat shock protein 90, putative 0.018 0.1142 1
Schistosoma mansoni hypothetical protein 0.0049 0.0263 0.0474
Loa Loa (eye worm) endoplasmin 0.0047 0.0251 0.0246
Toxoplasma gondii heat shock protein 75, putative 0.0032 0.0144 0.1259
Onchocerca volvulus 0.0353 0.2308 0.2303
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0156 0.0272
Echinococcus granulosus vesicular acetylcholine transporter 0.0465 0.3065 0.5525
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0088 0.0149
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0127 0.0122
Entamoeba histolytica peptidase, C54 family 0.0049 0.0262 0.104
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0265 0.0866
Plasmodium vivax heat shock protein 90, putative 0.0032 0.0144 0.0973
Schistosoma mansoni hypothetical protein 0.0494 0.3258 0.5877
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0074 0.0631
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0071
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.002 0.0064 0.0542
Echinococcus multilocularis endoplasmin 0.0045 0.0231 0.0347
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.0234 0.1505 0.15
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.002 0.0064 0.0247
Trypanosoma cruzi lanosterol synthase, putative 0.0347 0.2269 0.983
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0156 0.0231
Brugia malayi Hsp90 protein 0.0032 0.0144 0.0469
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0074 0.0646
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0465 0.3065 0.3062
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0076 0.0357
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0045 0.0231 0.1248
Schistosoma mansoni hypothetical protein 0.0058 0.0324 0.0584
Onchocerca volvulus 0.0029 0.0124 0.0119
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0125 0.054
Echinococcus multilocularis protocadherin 11 0.0011 0.0006 0.0001
Schistosoma mansoni hypothetical protein 0.0362 0.2369 0.4274
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0014 0.0025
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0137 0.0482
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0085 0.0254
Leishmania major heat shock protein 83-1 0.0047 0.0251 0.0983
Echinococcus granulosus jumonji domain containing 1A 0.0029 0.0127 0.022
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0025 0.0046
Brugia malayi Cell death specification protein 2 0.0011 0.0006 0.0019
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.0843 0.275
Loa Loa (eye worm) RecQ helicase 0.0026 0.011 0.0105
Schistosoma mansoni DNA helicase recq5 0.0011 0.0005 0.0009
Leishmania major heat shock protein 83-1 0.0047 0.0251 0.0983
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0052 0.0142
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0124 0.0489
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0049 0.0262 0.1033
Giardia lamblia Rab geranylgeranyltransferase 0.002 0.0064 0.0234
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0141 0.0245
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0141 0.0208
Loa Loa (eye worm) heat shock protein 75 0.0032 0.0144 0.0139
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0014 0.0025
Echinococcus multilocularis GPCR, family 2 0.005 0.0265 0.0399
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0265 0.047
Trypanosoma brucei heat shock protein, putative 0.0047 0.0251 0.1088
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0066 0.0356
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0049 0.0262 0.1137
Brugia malayi jmjC domain containing protein 0.0173 0.1095 0.3573
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0066 0.0356
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0005 0.0017
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0275 0.0414
Entamoeba histolytica hypothetical protein 0.0109 0.0665 0.2645
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0223 0.0393
Leishmania major heat shock protein 83-1 0.0047 0.0251 0.0983
Plasmodium vivax JmjC domain containing protein 0.0029 0.0127 0.0818
Plasmodium vivax heat shock protein 86, putative 0.0047 0.0251 0.1942
Onchocerca volvulus Phospholipase A2 homolog 0.1495 1 1
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1076 0.1642
Plasmodium falciparum protein farnesyltransferase subunit beta 0.002 0.0064 0.0542
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0014 0.0045
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0156 0.0566
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0173 0.0303
Brugia malayi jmjC domain containing protein 0.0029 0.0127 0.0413
Brugia malayi hypothetical protein 0.0011 0.0006 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0014 0.0045
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0001
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0117 0.0647
Plasmodium vivax geranylgeranyltransferase, putative 0.002 0.0064 0.0248
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0014 0.0045
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0304 0.0539
Schistosoma mansoni transcriptional factor nfil3/e4bp4 0.0011 0.0006 0.0011
Trypanosoma brucei heat shock protein, putative 0.0047 0.0251 0.1088
Loa Loa (eye worm) hypothetical protein 0.0119 0.0732 0.0728
Schistosoma mansoni protein farnesyltransferase subunit beta 0.002 0.0064 0.0115
Mycobacterium ulcerans heat shock protein 90 0.0045 0.0231 1
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0137 0.0592
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.0251 0.0994
Leishmania major heat shock protein 83-1 0.0047 0.0251 0.0983
Schistosoma mansoni coup transcription factor 0.0012 0.0014 0.0025

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 10 uM PUBCHEM_BIOASSAY: XBP1 DR counterscreen for CHOP. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2732, AID493217] ChEMBL. No reference
IC50 (functional) = 10 uM PUBCHEM_BIOASSAY: CHOP dose-response primary assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2732, AID493217] ChEMBL. No reference
Potency (functional) 0.1413 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.6511 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 1.7783 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.5686 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Saccharomyces cerevisiae ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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