Detailed information for compound 1511057

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 484.469 | Formula: C24H31Na3O6
  • H donors: 3 H acceptors: 6 LogP: 4.16 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C1=CC23CCC4C(C3CC1C(C2C(=O)[O-])C(=O)[O-])(C)CCCC4(C)C(=O)[O-])C.[Na+].[Na+].[Na+]
  • InChi: 1S/C24H34O6.3Na/c1-12(2)14-11-24-9-6-15-22(3,7-5-8-23(15,4)21(29)30)16(24)10-13(14)17(19(25)26)18(24)20(27)28;;;/h11-13,15-18H,5-10H2,1-4H3,(H,25,26)(H,27,28)(H,29,30);;;/q;3*+1/p-3
  • InChiKey: UZTSMZIYXQLLPO-UHFFFAOYSA-K  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 References
Homo sapiens replication protein A1, 70kDa References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense replication factor A, 51kDa subunit, putative Get druggable targets OG5_127539 All targets in OG5_127539
Echinococcus granulosus replication protein A 70 kDa DNA binding Get druggable targets OG5_127539 All targets in OG5_127539
Trypanosoma cruzi Replication factor A protein 1 Get druggable targets OG5_127539 All targets in OG5_127539
Echinococcus multilocularis replication protein A 70 kDa DNA binding Get druggable targets OG5_127539 All targets in OG5_127539
Entamoeba histolytica replication factor A protein 1, putative Get druggable targets OG5_127539 All targets in OG5_127539
Brugia malayi replication factor A 73 kDa subunit Get druggable targets OG5_127539 All targets in OG5_127539
Trichomonas vaginalis replication factor A 1, rfa1, putative Get druggable targets OG5_127539 All targets in OG5_127539
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Plasmodium berghei replication protein A1, large subunit, putative Get druggable targets OG5_127539 All targets in OG5_127539
Babesia bovis replication factor-a protein 1 (rpa1) family protein Get druggable targets OG5_127539 All targets in OG5_127539
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein Get druggable targets OG5_127539 All targets in OG5_127539
Leishmania donovani Replication factor A protein 1 Get druggable targets OG5_127539 All targets in OG5_127539
Candida albicans similar to single-stranded DNA binding protein involved in DNA-damage repair Get druggable targets OG5_127539 All targets in OG5_127539
Trichomonas vaginalis replication factor A 1, rfa1, putative Get druggable targets OG5_127539 All targets in OG5_127539
Plasmodium yoelii putative replication A protein Get druggable targets OG5_127539 All targets in OG5_127539
Schistosoma mansoni replication factor A 1 rfa1 Get druggable targets OG5_127539 All targets in OG5_127539
Leishmania major replication factor A, 51kDa subunit, putative Get druggable targets OG5_127539 All targets in OG5_127539
Plasmodium knowlesi replication protein A1, large subunit, putative Get druggable targets OG5_127539 All targets in OG5_127539
Plasmodium falciparum replication protein A1, large subunit Get druggable targets OG5_127539 All targets in OG5_127539
Leishmania infantum replication factor A, 51kDa subunit, putative Get druggable targets OG5_127539 All targets in OG5_127539
Plasmodium vivax replication protein A1, large subunit, putative Get druggable targets OG5_127539 All targets in OG5_127539
Cryptosporidium hominis replication protein A 70kDa Get druggable targets OG5_127539 All targets in OG5_127539
Onchocerca volvulus Putative replication factor A 73 kDa subunit Get druggable targets OG5_127539 All targets in OG5_127539
Trichomonas vaginalis replication factor A 1, rfa1, putative Get druggable targets OG5_127539 All targets in OG5_127539
Loa Loa (eye worm) replication factor A 73 kDa subunit Get druggable targets OG5_127539 All targets in OG5_127539
Leishmania mexicana replication factor A, 51kDa subunit, putative Get druggable targets OG5_127539 All targets in OG5_127539
Cryptosporidium parvum Rf-A (OB fold protein) Get druggable targets OG5_127539 All targets in OG5_127539
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania braziliensis replication factor A, 51kDa subunit, putative Get druggable targets OG5_127539 All targets in OG5_127539
Trypanosoma brucei Replication factor A protein 1 Get druggable targets OG5_127539 All targets in OG5_127539
Candida albicans similar to single-stranded DNA binding protein involved in DNA-damage repair Get druggable targets OG5_127539 All targets in OG5_127539
Trichomonas vaginalis replication factor A 1, rfa1, putative Get druggable targets OG5_127539 All targets in OG5_127539
Trypanosoma congolense Replication factor A protein 1 Get druggable targets OG5_127539 All targets in OG5_127539
Theileria parva replication factor A protein, putative Get druggable targets OG5_127539 All targets in OG5_127539
Schistosoma japonicum ko:K07466 replication factor A1, putative Get druggable targets OG5_127539 All targets in OG5_127539
Neospora caninum hypothetical protein Get druggable targets OG5_127539 All targets in OG5_127539
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum calcium-dependent protein kinase 5 0.0253 0.3247 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0052 0.0491 0.1057
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.015 0.1837 0.5615
Mycobacterium ulcerans aldehyde dehydrogenase 0.0102 0.1182 0.3445
Entamoeba histolytica cysteine protease, putative 0.0025 0.0124 0.03
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0253 0.3247 1
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0019 0.0035 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0449 0.1289
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0124 0.0674
Brugia malayi RhoGAP domain containing protein 0.0019 0.0042 0.0076
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0116 0.0211
Schistosoma mansoni C-fyn 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0064
Echinococcus multilocularis tumor protein p63 0.0408 0.5369 0.5353
Entamoeba histolytica protein kinase, putative 0.0253 0.3245 1
Echinococcus granulosus tumor protein p63 0.0408 0.5369 0.5353
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0043 0.0373 0.0339
Schistosoma mansoni hypothetical protein 0.0052 0.0491 0.0491
Onchocerca volvulus 0.0049 0.0449 0.0663
Brugia malayi Variant SH3 domain containing protein 0.0019 0.0035 0.0064
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0289 0.0356
Echinococcus granulosus cytochrome P450 2K1 0.0052 0.0491 0.0458
Schistosoma mansoni tensin 0.0019 0.0042 0.0042
Echinococcus multilocularis calcium dependent protein kinase 0.0247 0.3169 0.3145
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0192 0.2414 0.2387
Brugia malayi Peripheral plasma membrane protein CASK 0.0019 0.0035 0.0064
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0116 0.0211
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0052 0.0491 0.1057
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0192 0.2414 0.2387
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.015 0.1837 0.1837
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0064
Entamoeba histolytica cysteine protease, putative 0.0025 0.0124 0.03
Plasmodium vivax vivapain-2 0.0049 0.0449 0.1383
Brugia malayi SRC-1 0.0192 0.2414 0.4398
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0192 0.2414 0.2387
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0227 0.0308
Brugia malayi PAS domain containing protein 0.004 0.0329 0.0599
Echinococcus granulosus expressed conserved protein 0.0019 0.0042 0.0007
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0038 0.0299 0.0299
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0597 0.0564
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0025 0.0116 0.0081
Entamoeba histolytica cysteine protease, putative 0.0025 0.0124 0.03
Trichomonas vaginalis conserved hypothetical protein 0.015 0.1837 0.2886
Trypanosoma cruzi cysteine proteinase, putative 0.0025 0.0124 0.0674
Onchocerca volvulus 0.0049 0.0449 0.0663
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0116 0.0211
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.015 0.1837 0.1808
Echinococcus multilocularis N chimaerin 0.0019 0.0042 0.0007
Echinococcus multilocularis cysteine protease 0.0049 0.0449 0.0415
Trypanosoma cruzi cysteine peptidase, putative 0.0049 0.0449 0.2444
Onchocerca volvulus Cathepsin L homolog 0.0049 0.0449 0.0663
Echinococcus multilocularis cysteine protease 0.0049 0.0449 0.0415
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0052 0.0491 0.0727
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0076
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0253 0.3245 0.591
Echinococcus multilocularis 0.0052 0.0491 0.0458
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0168 0.2083 0.2055
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0052 0.0491 0.1057
Echinococcus multilocularis SH2 motif 0.0019 0.0042 0.0007
Plasmodium falciparum cGMP-dependent protein kinase 0.0106 0.1236 0.3698
Mycobacterium ulcerans aldehyde dehydrogenase 0.0102 0.1182 0.3445
Entamoeba histolytica hypothetical protein 0.0019 0.0035 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0449 0.0663
Loa Loa (eye worm) protein-tyrosine kinase 0.0019 0.0035 0.0064
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0025 0.012 0.0288
Brugia malayi Cytochrome P450 family protein 0.0101 0.1168 0.2128
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.1236 0.1236
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0106 0.1236 0.1205
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0449 0.0663
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0116 0.0211
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0449 0.0663
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.1236 0.1236
Schistosoma mansoni SH2A 0.0019 0.0042 0.0042
Trichomonas vaginalis esterase, putative 0.0037 0.0289 0.0406
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0124 0.03
Onchocerca volvulus 0.0025 0.0116 0.0129
Brugia malayi Tyrosine-protein kinase abl-1 0.0043 0.0373 0.0679
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0052 0.0491 0.1057
Brugia malayi Cathepsin L-like precursor 0.0049 0.0449 0.0818
Leishmania major protein kinase, putative 0.0029 0.0181 0.0455
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0106 0.1236 0.3698
Brugia malayi hypothetical protein 0.0135 0.1625 0.2961
Trypanosoma cruzi cysteine peptidase, putative 0.0049 0.0449 0.2444
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0289 0.0406
Schistosoma mansoni cathepsin F (C01 family) 0.0049 0.0449 0.0449
Plasmodium vivax unspecified product 0.0025 0.0124 0.0381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0449 0.0663
Brugia malayi Cathepsin L-like precursor 0.0033 0.0227 0.0414
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0052 0.0491 0.1421
Brugia malayi Variant SH3 domain containing protein 0.0019 0.0042 0.0076
Trichomonas vaginalis CAMK family protein kinase 0.0253 0.3245 0.514
Plasmodium falciparum calcium-dependent protein kinase 3 0.0253 0.3247 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0049 0.0449 0.0818
Leishmania major cathepsin L-like protease 0.0049 0.0449 0.1289
Brugia malayi cathepsin L-like precursor 0.0033 0.0227 0.0414
Echinococcus granulosus tyrosine protein kinase Blk 0.0174 0.2157 0.213
Onchocerca volvulus 0.0019 0.0042 0.001
Schistosoma mansoni tyrosine kinase 0.0025 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0037 0.0289 0.0526
Schistosoma mansoni replication factor A 1 rfa1 0.0042 0.0357 0.0357
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0052 0.0491 0.1057
Schistosoma mansoni hypothetical protein 0.0019 0.0042 0.0042
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0019 0.0042 0.0007
Loa Loa (eye worm) p53BP2 0.0019 0.0035 0.0064
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0052 0.0491 0.1057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0449 0.1289
Loa Loa (eye worm) TK/ABL protein kinase 0.0025 0.0116 0.0211
Entamoeba histolytica cysteine proteinase 1, putative 0.0025 0.0124 0.03
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0076
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0289 0.0526
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0102 0.1182 0.3203
Entamoeba histolytica cysteine protease, putative 0.0025 0.0124 0.03
Brugia malayi Papain family cysteine protease containing protein 0.0049 0.0449 0.0818
Loa Loa (eye worm) hypothetical protein 0.0025 0.0116 0.0211
Brugia malayi Variant SH3 domain containing protein 0.0019 0.0035 0.0064
Entamoeba histolytica hypothetical protein, conserved 0.0019 0.0035 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0449 0.0663
Toxoplasma gondii aldehyde dehydrogenase 0.0102 0.1182 0.3529
Brugia malayi Pre-SET motif family protein 0.0417 0.549 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0449 0.0663
Echinococcus granulosus calcium dependent protein kinase 0.0247 0.3169 0.3145
Echinococcus multilocularis tensin 0.0019 0.0042 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0289 0.0889
Onchocerca volvulus 0.0037 0.0289 0.0406
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0064
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0116 0.0211
Loa Loa (eye worm) hypothetical protein 0.0037 0.0289 0.0526
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0449 0.1289
Brugia malayi Variant SH3 domain containing protein 0.0038 0.0299 0.0544
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0597 0.0597
Trypanosoma cruzi cytochrome P450, putative 0.0119 0.1411 0.7679
Schistosoma mansoni protein kinase 0.0253 0.3245 0.3245
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0019 0.0042 0.0076
Echinococcus granulosus suppressor of cytokine signaling 7 0.0019 0.0042 0.0007
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0019 0.0035 0.0035
Entamoeba histolytica cysteine protease, putative 0.0025 0.0124 0.03
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0124 0.03
Brugia malayi SH2 domain containing protein 0.0019 0.0042 0.0076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0076
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.0042 0.0076
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0289 0.0406
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0025 0.0116 0.0081
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0019 0.0042 0.0007
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0116 0.0211
Brugia malayi Egg laying defective protein 4 0.0106 0.1236 0.2251
Echinococcus granulosus tyrosine protein kinase Src42A 0.0168 0.2083 0.2055
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.015 0.1837 0.2886
Schistosoma mansoni tyrosine kinase 0.0043 0.0373 0.0373
Brugia malayi protein-tyrosine kinase 0.0019 0.0035 0.0064
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0253 0.3245 0.591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0449 0.1289
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0449 0.1311
Loa Loa (eye worm) TK protein kinase 0.0174 0.2157 0.393
Trypanosoma brucei cytochrome P450, putative 0.0119 0.1411 0.4286
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0116 0.0211
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0253 0.3245 0.3221
Echinococcus multilocularis SHC transforming protein 3 0.0019 0.0042 0.0007
Echinococcus multilocularis 0.0019 0.0042 0.0007
Brugia malayi Variant SH3 domain containing protein 0.0019 0.0035 0.0064
Loa Loa (eye worm) hypothetical protein 0.0135 0.1625 0.2961
Loa Loa (eye worm) hypothetical protein 0.0049 0.0449 0.0818
Echinococcus multilocularis c src tyrosine kinase 0.0043 0.0373 0.0339
Schistosoma mansoni signal transduction protein lnk-related 0.0019 0.0042 0.0042
Schistosoma mansoni cathepsin F (C01 family) 0.0049 0.0449 0.0449
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0019 0.0042 0.0007
Brugia malayi protein-tyrosine kinase 0.0174 0.2157 0.393
Echinococcus granulosus cGMP dependent protein kinase 0.0106 0.1236 0.1205
Trypanosoma cruzi cysteine peptidase, putative 0.0049 0.0449 0.2444
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0289 0.0406
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0076
Echinococcus granulosus suppressor of cytokine signaling 6 0.0019 0.0042 0.0007
Entamoeba histolytica SH2 domain containing protein 0.0019 0.0042 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0449 0.1289
Brugia malayi Fes/CIP4 homology domain containing protein 0.0019 0.0035 0.0064
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0241 0.3077 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0253 0.3247 1
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0116 0.0211
Brugia malayi Protein kinase domain containing protein 0.0025 0.0116 0.0211
Onchocerca volvulus 0.006 0.0597 0.0899
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0049 0.0449 0.0663
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0124 0.03
Brugia malayi Sex muscle abnormal protein 5 0.0038 0.0299 0.0544
Onchocerca volvulus 0.0049 0.0449 0.0663
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0192 0.2414 0.2387
Brugia malayi follicle stimulating hormone receptor 0.0379 0.4965 0.9045
Schistosoma mansoni sorbin 0.0019 0.0035 0.0035
Brugia malayi SH2 domain containing protein 0.0019 0.0042 0.0076
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0049 0.0449 0.1232
Echinococcus granulosus tyrosine protein kinase Fyn 0.0192 0.2414 0.2387
Echinococcus granulosus cathepsin l cysteine peptidase 0.0049 0.0449 0.0415
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0035 0.0192
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.015 0.1837 0.5626
Onchocerca volvulus 0.0025 0.0116 0.0129
Onchocerca volvulus 0.0049 0.0449 0.0663
Schistosoma mansoni tyrosine kinase 0.0192 0.2414 0.2414
Entamoeba histolytica hypothetical protein 0.0019 0.0035 0.0025
Brugia malayi cytokine inducible SH2-containing protein 5 0.0019 0.0042 0.0076
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0124 0.03
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0449 0.0663
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0253 0.3245 0.3221
Echinococcus granulosus N chimaerin 0.0019 0.0042 0.0007
Leishmania major cathepsin L-like protease 0.0049 0.0449 0.1289
Loa Loa (eye worm) beta-lactamase 0.0037 0.0289 0.0526
Loa Loa (eye worm) thyroid receptor interactor 0.0019 0.0035 0.0064
Brugia malayi SH3 domain containing protein 0.0019 0.0035 0.0064
Loa Loa (eye worm) hypothetical protein 0.015 0.1837 0.3347
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0289 0.0254
Plasmodium falciparum cysteine proteinase falcipain 3 0.0049 0.0449 0.1232
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0289 0.0406
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0289 0.0526
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.304 0.9864
Loa Loa (eye worm) cysteine protease 0.0049 0.0449 0.0818
Brugia malayi hypothetical protein 0.0019 0.0042 0.0076
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0049 0.0449 0.0818
Brugia malayi Cathepsin L-like precursor 0.0049 0.0449 0.0818
Brugia malayi Protein kinase domain containing protein 0.0025 0.0116 0.0211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0449 0.1289
Echinococcus multilocularis tyrosine protein kinase shark 0.0025 0.0116 0.0081
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0035 0.0192
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0052 0.0491 0.1057
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0449 0.1311
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0449 0.0663
Leishmania major cathepsin L-like protease 0.0049 0.0449 0.1289
Leishmania major cysteine peptidase A (CPA) 0.0049 0.0449 0.1289
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0253 0.3247 1
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0597 0.0597
Brugia malayi Variant SH3 domain containing protein 0.0019 0.0035 0.0064
Brugia malayi SH2 domain containing protein 0.0019 0.0042 0.0076
Leishmania major cathepsin L-like protease 0.0049 0.0449 0.1289
Brugia malayi hypoxia-induced factor 1 0.0124 0.1482 0.27
Plasmodium vivax vivapain-3 0.0025 0.0124 0.0381
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.015 0.1837 0.1837
Onchocerca volvulus 0.003 0.0186 0.0241
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0289 0.0254
Toxoplasma gondii ABC1 family protein 0.0037 0.0289 0.073
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0052 0.0491 0.2675
Schistosoma mansoni tensin 0.0019 0.0042 0.0042
Schistosoma mansoni adapter molecule crk 0.0038 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0037 0.0289 0.0526
Schistosoma mansoni aldehyde dehydrogenase 0.0102 0.1182 0.1182
Onchocerca volvulus 0.0049 0.0449 0.0663
Leishmania major cathepsin L-like protease 0.0049 0.0449 0.1289
Schistosoma mansoni cell polarity protein 0.0019 0.0035 0.0035
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0049 0.0449 0.1232
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0019 0.0035 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0052 0.0491 0.0727
Brugia malayi Cathepsin L-like precursor 0.0049 0.0449 0.0818
Schistosoma mansoni vav2 0.0019 0.0042 0.0042
Entamoeba histolytica protein kinase, putative 0.0025 0.012 0.0288
Mycobacterium leprae Conserved hypothetical protein 0.0052 0.0491 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0253 0.3247 1
Loa Loa (eye worm) STAT protein 0.0019 0.0042 0.0076
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0289 0.0289
Echinococcus granulosus cathepsin L 0.0025 0.0124 0.0089
Echinococcus multilocularis signal transduction protein lnk realted 0.0019 0.0042 0.0007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0449 0.0663
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0227 0.0622
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0289 0.0406
Loa Loa (eye worm) AGC/PKG protein kinase 0.0106 0.1236 0.2251
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0052 0.0491 0.0727
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0052 0.0491 0.0727
Entamoeba histolytica cysteine protease, putative 0.0025 0.0124 0.03
Brugia malayi Guanylate kinase family protein 0.0019 0.0035 0.0064
Echinococcus granulosus cathepsin l1 0.0049 0.0449 0.0415
Toxoplasma gondii cytochrome p450 superfamily protein 0.0052 0.0491 0.1365
Onchocerca volvulus Cathepsin L homolog 0.0049 0.0449 0.0663
Trypanosoma cruzi cytochrome P450, putative 0.0119 0.1411 0.7679
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0597 0.0564
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.015 0.1837 0.1808
Echinococcus granulosus ubiquitin specific protease 41 0.015 0.1837 0.1808
Loa Loa (eye worm) cytochrome P450 0.0052 0.0491 0.0895
Brugia malayi SH2 domain containing protein 0.0019 0.0042 0.0076
Entamoeba histolytica hypothetical protein 0.0019 0.0035 0.0025
Echinococcus granulosus cathepsin l1 0.0033 0.0227 0.0193
Brugia malayi STAT protein, DNA binding domain containing protein 0.0019 0.0042 0.0076
Echinococcus granulosus SH2 motif 0.0019 0.0042 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0076
Loa Loa (eye worm) fibroinase 0.0049 0.0449 0.0818
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0019 0.0042 0.0076
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0019 0.0042 0.0007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0449 0.0663
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0019 0.0042 0.0007
Loa Loa (eye worm) cytochrome P450 family protein 0.0101 0.1168 0.2128
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0379 0.4965 0.9045
Schistosoma mansoni dreadlocks/dock 0.0019 0.0035 0.0035
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.015 0.1837 0.1808
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0019 0.0035 0.0035
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0052 0.0491 0.2675
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0253 0.3245 1
Brugia malayi SH2 domain containing protein 0.0019 0.0042 0.0076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0064
Loa Loa (eye worm) hypothetical protein 0.0033 0.0227 0.0414
Mycobacterium ulcerans epoxide hydrolase EphA 0.0241 0.3077 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0253 0.3247 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0025 0.0124 0.0674
Entamoeba histolytica unconventional myosin IB 0.0019 0.0035 0.0025
Entamoeba histolytica hypothetical protein 0.0019 0.0035 0.0025
Brugia malayi Protein kinase domain containing protein 0.0025 0.0116 0.0211
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0019 0.0035 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0597 0.0597
Echinococcus granulosus SH2 domain containing protein 7 0.0019 0.0042 0.0007
Mycobacterium ulcerans lipase LipD 0.0037 0.0289 0.0356
Echinococcus multilocularis SH2 domain containing protein 7 0.0019 0.0042 0.0007
Echinococcus multilocularis growth factor receptor bound protein 2 0.0038 0.0299 0.0264
Echinococcus granulosus tyrosine kinase 0.0174 0.2157 0.213
Echinococcus multilocularis tyrosine protein kinase Srms 0.0174 0.2157 0.213
Schistosoma mansoni hypothetical protein 0.0019 0.0037 0.0037
Onchocerca volvulus 0.0037 0.0289 0.0406
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0019 0.0042 0.0007
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0052 0.0491 0.0727
Schistosoma mansoni tyrosine kinase 0.0025 0.0116 0.0116
Loa Loa (eye worm) SH2 domain-containing protein 0.0019 0.0042 0.0076
Echinococcus granulosus single minded 2 0.003 0.0186 0.0151
Schistosoma mansoni shc transforming protein 0.0019 0.0042 0.0042
Brugia malayi Tensin 0.0019 0.0042 0.0076
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0052 0.0491 0.1057
Echinococcus multilocularis cathepsin L cysteine protease 0.0049 0.0449 0.0415
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0192 0.2414 0.2387
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0106 0.1236 0.1205
Schistosoma mansoni tyrosine kinase 0.0043 0.0373 0.0373
Leishmania major replication factor A, 51kDa subunit, putative 0.002 0.0056 0.0064
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0049 0.0449 0.0415
Brugia malayi Cytochrome P450 family protein 0.0052 0.0491 0.0895
Trypanosoma brucei Replication factor A protein 1 0.002 0.0056 0.0064
Echinococcus granulosus tyrosine protein kinase Fyn 0.0192 0.2414 0.2387
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0289 0.1571
Brugia malayi SH2 domain containing protein 0.0019 0.0042 0.0076
Brugia malayi Cathepsin L-like cysteine proteinase 0.0033 0.0227 0.0414
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0076
Plasmodium vivax vivapain-1 0.0025 0.0124 0.0381
Schistosoma mansoni hypothetical protein 0.0019 0.0035 0.0035
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0192 0.2414 0.2387
Echinococcus granulosus signal transduction protein lnk realted 0.0019 0.0042 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0449 0.1289
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0192 0.2414 0.2387
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0174 0.2157 0.213
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0289 0.0289
Trypanosoma cruzi cysteine peptidase, putative 0.0049 0.0449 0.2444
Entamoeba histolytica BAR/SH3 domain containing protein 0.0019 0.0035 0.0025
Leishmania major hypothetical protein, conserved 0.0037 0.0289 0.079
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0124 0.0225
Schistosoma mansoni single-minded 0.004 0.0329 0.0329
Echinococcus granulosus tyrosine kinase 0.0025 0.0116 0.0081
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0116 0.0211
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0102 0.1182 0.3573
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0076
Echinococcus granulosus tyrosine protein kinase Srms 0.0025 0.0116 0.0081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0597 0.0597
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0597 0.1698
Trypanosoma cruzi cysteine proteinase, putative 0.0025 0.0124 0.0674
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0019 0.0042 0.0007
Brugia malayi bHLH-PAS transcription factor 0.003 0.0186 0.0338
Echinococcus multilocularis tensin 0.0019 0.0042 0.0007
Leishmania major protein kinase, putative 0.0019 0.0038 0.0009
Echinococcus granulosus tyrosine protein kinase shark 0.0025 0.0116 0.0081
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0019 0.0042 0.0042
Brugia malayi Variant SH3 domain containing protein 0.0019 0.0042 0.0076
Onchocerca volvulus 0.0037 0.0289 0.0406
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0019 0.0042 0.0076
Loa Loa (eye worm) SH2 domain-containing protein 0.0019 0.0042 0.0076
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0019 0.0035 0.0035
Mycobacterium ulcerans hypothetical protein 0.0037 0.0289 0.0356
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0025 0.0116 0.0081
Onchocerca volvulus 0.0033 0.0227 0.0308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0449 0.0663
Onchocerca volvulus 0.0049 0.0449 0.0663
Schistosoma mansoni hypothetical protein 0.0019 0.0042 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0124 0.0142
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0192 0.2414 0.2387
Schistosoma mansoni cytochrome P450 0.0052 0.0491 0.0491
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0289 0.079
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.0042 0.0076
Echinococcus granulosus SH2 motif 0.0019 0.0042 0.0007
Leishmania major cathepsin L-like protease 0.0049 0.0449 0.1289
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0253 0.3245 0.3221
Brugia malayi Cytochrome P450 family protein 0.0119 0.1411 0.257
Entamoeba histolytica cysteine protease, putative 0.0025 0.0124 0.03
Entamoeba histolytica cysteine protease, putative 0.0025 0.0124 0.03
Brugia malayi beta-lactamase 0.0037 0.0289 0.0526
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0038 0.0296 0.0418
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0019 0.0042 0.001
Loa Loa (eye worm) CYP4Cod1 0.0119 0.1411 0.257
Echinococcus granulosus SH2 domain containing adapter protein F 0.0019 0.0042 0.0007
Echinococcus granulosus SHC transforming protein 3 0.0019 0.0042 0.0007
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0253 0.3245 0.3221
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0192 0.2414 0.2387
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0449 0.0663
Loa Loa (eye worm) SRC-1 0.0192 0.2414 0.4398
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0102 0.1182 0.1151
Schistosoma mansoni tensin-related 0.0019 0.0042 0.0042
Brugia malayi Cathepsin L-like precursor 0.0049 0.0449 0.0818
Entamoeba histolytica hypothetical protein 0.0019 0.0035 0.0025
Brugia malayi Cam kinase protein 1 0.0253 0.3245 0.591
Echinococcus granulosus tyrosine protein kinase HCK 0.0154 0.1894 0.1865
Echinococcus multilocularis tyrosine protein kinase Abl 0.0043 0.0373 0.0339
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0033 0.0227 0.1237
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0544
Echinococcus multilocularis tyrosine kinase 0.0025 0.0116 0.0081
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0052 0.0491 0.0727
Schistosoma mansoni peptidase 0.0018 0.0023 0.0023
Brugia malayi Cathepsin L-like precursor 0.0033 0.0227 0.0414
Entamoeba histolytica cysteine protease, putative 0.0025 0.0124 0.03
Echinococcus multilocularis tyrosine protein kinase HCK 0.0154 0.1894 0.1865
Schistosoma mansoni suppressor of cytokine signaling 0.0019 0.0042 0.0042
Echinococcus granulosus tyrosine protein kinase ABL1 0.0025 0.0116 0.0081
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0253 0.3247 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0049 0.0449 0.0415
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0289 0.1571
Entamoeba histolytica BAR/SH3 domain containing protein 0.0019 0.0035 0.0025
Echinococcus granulosus cathepsin L cysteine protease 0.0025 0.0124 0.0089
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0038 0.0038
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0052 0.0491 0.0727
Brugia malayi Spectrin alpha chain 0.0019 0.0037 0.0068
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0174 0.2157 0.213
Brugia malayi SH2 domain containing protein 0.0025 0.0116 0.0211
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0052 0.0491 0.0727
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0052 0.0491 0.0727
Schistosoma mansoni formin binding protein and related proteins 0.0019 0.0035 0.0035
Onchocerca volvulus 0.0024 0.0113 0.0125
Brugia malayi cytochrome P450 0.0052 0.0491 0.0895
Entamoeba histolytica cysteine protease, putative 0.0049 0.0449 0.1311
Entamoeba histolytica protein kinase, putative 0.0253 0.3245 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0064
Brugia malayi Src substrate cortactin 0.0019 0.0035 0.0064
Onchocerca volvulus 0.006 0.0597 0.09
Loa Loa (eye worm) hypothetical protein 0.0037 0.0289 0.0526
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0253 0.3245 0.3221
Echinococcus multilocularis SH2 motif 0.0019 0.0042 0.0007
Trypanosoma cruzi cruzipain precursor, putative 0.0049 0.0449 0.2444
Echinococcus multilocularis NCK adaptor protein 0.0038 0.0299 0.0264
Leishmania major cathepsin L-like protease 0.0049 0.0449 0.1289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0449 0.0663
Mycobacterium ulcerans hypothetical protein 0.0101 0.1158 0.3362
Echinococcus multilocularis SH2 motif 0.0019 0.0042 0.0007
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0038 0.0299 0.0544
Entamoeba histolytica hypothetical protein 0.0019 0.0035 0.0025
Onchocerca volvulus 0.0019 0.0042 0.001
Onchocerca volvulus 0.0019 0.0042 0.001
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.004 0.0329 0.047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0449 0.0663
Onchocerca volvulus 0.0025 0.0116 0.0129
Onchocerca volvulus Cathepsin F homolog 0.0049 0.0449 0.0663
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0049 0.0449 0.0663
Trypanosoma cruzi Replication factor A protein 1 0.002 0.0056 0.0303
Echinococcus granulosus hypothetical protein 0.0019 0.0042 0.0007
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0253 0.3247 1
Entamoeba histolytica cysteine protease, putative 0.0025 0.0124 0.03
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0597 0.0564
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0038 0.0299 0.0544
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0052 0.0491 0.0727
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0019 0.0035 0.0192
Schistosoma mansoni suppressor of cytokine signaling 0.0019 0.0042 0.0042
Echinococcus granulosus tyrosine protein kinase Lyn 0.0198 0.2492 0.2466
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0597 0.0597
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0052 0.0491 0.0727
Mycobacterium leprae putative cytochrome p450 0.0052 0.0491 1
Brugia malayi SH2 domain containing protein 0.0025 0.0116 0.0211
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0289 0.0356
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0064
Echinococcus multilocularis transfer RNA-Lys 0.003 0.0186 0.0151
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0019 0.0042 0.0042
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0019 0.0042 0.0007
Onchocerca volvulus 0.0019 0.0042 0.001
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0052 0.0491 0.1057
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0052 0.0491 0.1057
Brugia malayi Cathepsin L-like precursor 0.0049 0.0449 0.0818
Brugia malayi Cathepsin L-like precursor 0.0049 0.0449 0.0818
Leishmania major cytochrome p450-like protein 0.0119 0.1411 0.4286
Echinococcus multilocularis ubiquitin specific protease 41 0.015 0.1837 0.1808
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0076
Plasmodium vivax SET domain protein, putative 0.006 0.0597 0.184
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0043 0.0373 0.0373
Echinococcus multilocularis expressed conserved protein 0.0106 0.1236 0.1205
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0025 0.0124 0.0124
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0025 0.0116 0.0275
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0192 0.2414 0.2387
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0052 0.0491 0.1057
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0042 0.0357 0.0323
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.015 0.1837 0.1808
Schistosoma mansoni serine/threonine protein kinase 0.0253 0.3245 0.3245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0449 0.1289
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0116 0.0211
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0019 0.0042 0.0007
Brugia malayi Variant SH3 domain containing protein 0.0038 0.0299 0.0544
Schistosoma mansoni tensin 0.0019 0.0042 0.0042
Brugia malayi Protein kinase domain containing protein 0.0025 0.0116 0.0211
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0019 0.0042 0.0042
Entamoeba histolytica cysteine proteinase 2 0.0025 0.0124 0.03
Onchocerca volvulus 0.0019 0.0042 0.001
Brugia malayi Cytochrome P450 family protein 0.0119 0.1411 0.257
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0109 0.0109
Echinococcus granulosus cGMP dependent protein kinase 1 0.0106 0.1236 0.1205
Schistosoma mansoni protein kinase 0.0253 0.3245 0.3245
Brugia malayi beta-lactamase family protein 0.0037 0.0289 0.0526
Brugia malayi Variant SH3 domain containing protein 0.0019 0.0035 0.0064
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0052 0.0491 0.1057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0124 0.0142
Loa Loa (eye worm) guanylate kinase 0.0019 0.0035 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0449 0.1289
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0052 0.0491 0.0727
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.015 0.1837 0.3347
Entamoeba histolytica hypothetical protein 0.0019 0.0035 0.0025
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0253 0.3247 1
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0035 0.0192
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0253 0.3247 1
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0019 0.0042 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0076
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0019 0.0042 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0449 0.0663
Plasmodium vivax calcium-dependent protein kinase, putative 0.0253 0.3247 1
Leishmania major cytochrome p450-like protein 0.0052 0.0491 0.1421
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0019 0.0042 0.001
Onchocerca volvulus 0.0474 0.6279 1
Schistosoma mansoni nck2/grb4 0.0038 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0033 0.0227 0.0414
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0052 0.0491 0.1057
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0025 0.0124 0.0124
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0449 0.0663
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.015 0.1837 0.5
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0049 0.0449 0.0415
Schistosoma mansoni growth factor receptor-bound protein 0.0038 0.0299 0.0299
Toxoplasma gondii cathepsin CPL 0.0049 0.0449 0.1232
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0042 0.0357 0.0323
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0076
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.015 0.1837 0.2886
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0052 0.0491 0.1057
Plasmodium vivax replication protein A1, large subunit, putative 0.002 0.0056 0.0172
Echinococcus multilocularis cathepsin L 0.0025 0.0124 0.0089
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0043 0.0373 0.0339
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0449 0.0663
Plasmodium falciparum cysteine proteinase falcipain 1 0.0025 0.0124 0.0213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0064
Echinococcus granulosus growth factor receptor bound protein 2 0.0038 0.0299 0.0264
Schistosoma mansoni GTPase activating protein 0.0019 0.0042 0.0042
Plasmodium vivax vivapain-2 0.0049 0.0449 0.1383
Echinococcus multilocularis cathepsin L cysteine protease 0.0049 0.0449 0.0415
Schistosoma mansoni run and tbc1 domain containing 0.0019 0.0035 0.0035
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0052 0.0491 0.1057
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0227 0.0227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0124 0.0276
Brugia malayi SH2 domain containing protein 0.0019 0.0042 0.0076
Schistosoma mansoni tensin-related 0.0019 0.0042 0.0042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0449 0.1289
Echinococcus granulosus tyrosine protein kinase Fyn 0.0192 0.2414 0.2387
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0042 0.0357 0.0651
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0076
Loa Loa (eye worm) hypothetical protein 0.006 0.0597 0.1087
Schistosoma mansoni aryl hydrocarbon receptor 0.004 0.0329 0.0329
Entamoeba histolytica protein kinase, putative 0.0019 0.0035 0.0025
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0019 0.0042 0.0007
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0052 0.0491 0.1057
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0052 0.0491 0.1421
Echinococcus granulosus cysteine protease 0.0025 0.0124 0.0089
Loa Loa (eye worm) hypoxia-induced factor 1 0.0124 0.1482 0.27
Brugia malayi beta-lactamase family protein 0.0037 0.0289 0.0526
Schistosoma mansoni tyrosine kinase 0.0192 0.2414 0.2414
Entamoeba histolytica cysteine protease, putative 0.0025 0.0124 0.03
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0449 0.0663
Schistosoma mansoni Dab2-interacting protein-like 0.0019 0.0035 0.0035
Onchocerca volvulus 0.0025 0.0116 0.0129
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0192 0.2414 0.2387
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0052 0.0491 0.0727
Loa Loa (eye worm) SH2 domain-containing protein 0.0019 0.0042 0.0076
Entamoeba histolytica hypothetical protein, conserved 0.0019 0.0035 0.0025
Schistosoma mansoni apoptosis stimulating of P53 0.0019 0.0035 0.0035
Schistosoma mansoni sorting nexin 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0033 0.0227 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0597 0.1088
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0102 0.1182 0.1151
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.015 0.1837 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0025 0.0124 0.0124
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.015 0.1837 0.5615
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0052 0.0491 0.1057
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0052 0.0491 0.1057
Onchocerca volvulus 0.0025 0.0116 0.0129
Brugia malayi Pre-SET motif family protein 0.006 0.0597 0.1088
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0119 0.1411 0.4237
Loa Loa (eye worm) hypothetical protein 0.0067 0.0698 0.1271
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0019 0.0042 0.0042
Loa Loa (eye worm) ctsf protein 0.0049 0.0449 0.0818
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0052 0.0491 0.0727
Schistosoma mansoni protein kinase 0.0253 0.3245 0.3245
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0049 0.0449 0.0663
Echinococcus multilocularis Spectrin alpha actinin 0.0019 0.0037 0.0002
Echinococcus granulosus tyrosine protein kinase Src42A 0.0192 0.2414 0.2387
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.002 0.0056 0.0033
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0052 0.0491 0.2675
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0449 0.0663
Loa Loa (eye worm) TK protein kinase 0.0154 0.1894 0.345
Onchocerca volvulus 0.0019 0.0042 0.001
Brugia malayi Variant SH3 domain containing protein 0.0019 0.0035 0.0064
Trypanosoma cruzi cysteine protease, putative 0.0025 0.0124 0.0674
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0076
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0052 0.0491 0.0727
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0124 0.0276
Trichomonas vaginalis set domain proteins, putative 0.0474 0.6279 1
Entamoeba histolytica protein kinase, putative 0.0154 0.1894 0.5801
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0253 0.3245 0.3221
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.015 0.1837 1
Loa Loa (eye worm) hypothetical protein 0.0253 0.3245 0.591
Leishmania major cytochrome p450-like protein 0.0052 0.0491 0.1421
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0227 0.0308
Brugia malayi Protein kinase domain containing protein 0.0025 0.0116 0.0211
Mycobacterium ulcerans aldehyde dehydrogenase 0.0102 0.1182 0.3445
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0449 0.0663
Schistosoma mansoni growth factor receptor-bound protein 0.0038 0.0299 0.0299
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0052 0.0491 0.1057
Leishmania major protein kinase, putative 0.0253 0.3245 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0052 0.0491 0.1057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0289 0.0526
Loa Loa (eye worm) hypothetical protein 0.0037 0.0289 0.0526
Loa Loa (eye worm) cytochrome P450 family protein 0.0119 0.1411 0.257
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0042 0.0357 0.0516
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0124 0.0225
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0042 0.0357 0.0516
Brugia malayi Myosin tail family protein 0.0019 0.0035 0.0064
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0567 0.0534
Brugia malayi replication factor A 73 kDa subunit 0.0042 0.0357 0.0651
Schistosoma mansoni eps8-related protein 0.0019 0.0035 0.0035
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0253 0.3245 0.3221
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0052 0.0491 0.0727
Echinococcus multilocularis tyrosine protein kinase Blk 0.0174 0.2157 0.213
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0052 0.0491 0.0727
Echinococcus granulosus tensin 0.0019 0.0042 0.0007
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0253 0.3245 0.3221
Entamoeba histolytica cysteine protease, putative 0.0025 0.0124 0.03
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0253 0.3245 0.591
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0052 0.0491 0.0727
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0449 0.0663
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0449 0.0663
Mycobacterium ulcerans beta-lactamase 0.0037 0.0289 0.0356
Schistosoma mansoni aldehyde dehydrogenase 0.0102 0.1182 0.1182
Echinococcus granulosus c src tyrosine kinase 0.0043 0.0373 0.0339
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0076
Leishmania major cathepsin L-like protease 0.0049 0.0449 0.1289
Onchocerca volvulus 0.0025 0.0116 0.0129
Schistosoma mansoni dynamin-associated protein 0.0019 0.0035 0.0035
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0052 0.0491 0.0727
Brugia malayi tRNA modification GTPase TrmE family protein 0.0019 0.0042 0.0076
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0417 0.549 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0019 0.0042 0.0007
Entamoeba histolytica cysteine protease, putative 0.0025 0.0124 0.03
Brugia malayi hypothetical protein 0.0025 0.0116 0.0211
Echinococcus granulosus cGMP dependent protein kinase 1 0.0106 0.1236 0.1205
Echinococcus granulosus NCK adaptor protein 0.0038 0.0299 0.0264
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0052 0.0491 0.0727
Onchocerca volvulus 0.0049 0.0449 0.0663
Entamoeba histolytica hypothetical protein 0.0019 0.0035 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0049 0.0449 0.1289
Echinococcus granulosus Spectrin alpha actinin 0.0019 0.0037 0.0002
Echinococcus granulosus tyrosine protein kinase Src64B 0.0192 0.2414 0.2387
Loa Loa (eye worm) cytochrome P450 family protein 0.0119 0.1411 0.257

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 10 uM Inhibition of GST-tagged p53/recombinant human N-terminal domain of RPA70 DNA binding domain interaction by electrophoretic mobility shift assay ChEMBL. 21459001
Inhibition (binding) Inhibition of recombinant human N-terminal domain of RPA70 DNA binding domain-F binding to 30-mer double strand DNA at <100 uM preincubated for 5mins before dsDNA addition measured after 30 mins by electrophoretic mobility shift assay ChEMBL. 21459001
Inhibition (binding) Inhibition of recombinant human N-terminal domain of RPA70 DNA binding domain-F binding to 30-mer single strand DNA at <100 uM preincubated for 5mins before ssDNA addition measured after 30 mins by electrophoretic mobility shift assay ChEMBL. 21459001

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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