Detailed information for compound 1527050

Basic information

Technical information
  • TDR Targets ID: 1527050
  • Name: [8-tert-butyl-3-(hydroxymethyl)-1-oxa-4-azasp iro[4.5]decan-3-yl]methanol
  • MW: 257.369 | Formula: C14H27NO3
  • H donors: 3 H acceptors: 2 LogP: 1.11 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1(CO)COC2(N1)CCC(CC2)C(C)(C)C
  • InChi: 1S/C14H27NO3/c1-12(2,3)11-4-6-14(7-5-11)15-13(8-16,9-17)10-18-14/h11,15-17H,4-10H2,1-3H3
  • InChiKey: DISPOMZMACBSJV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (8-tert-butyl-3-methylol-1-oxa-4-azaspiro[4.5]decan-3-yl)methanol
  • EU-0050055
  • ChemDiv2_001437
  • STK059808
  • MLS000090293
  • SMR000024903
  • [8-tert-butyl-3-(hydroxymethyl)-1-oxa-4-azaspiro[4.5]dec-3-yl]methanol
  • Oprea1_707910

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0061 0.0081
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.003 0.0126 0.0317
Mycobacterium ulcerans oxidoreductase GMC-type 0.0081 0.0484 0.0888
Mycobacterium tuberculosis Conserved hypothetical protein 0.0234 0.1556 0.4148
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.003 0.0126 0.0317
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0016 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0012 0.0041
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0441 0.3004 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0261 0.0351
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0199 0.0661
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0022 0.0073
Mycobacterium tuberculosis Possible oxidoreductase 0.0081 0.0484 0.1277
Echinococcus multilocularis Ankyrin 0.0014 0.0017 0.0016
Mycobacterium ulcerans heat shock protein 90 0.0028 0.011 0.0192
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0227 0.0226
Echinococcus granulosus lysine specific histone demethylase 1A 0.0234 0.1556 0.1556
Brugia malayi Protein kinase domain containing protein 0.0015 0.0019 0.0025
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.003 0.0029
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.003 0.0126 0.0221
Onchocerca volvulus 0.002 0.0059 0.0078
Wolbachia endosymbiont of Brugia malayi 2-polyprenyl-6-methoxyphenol 4-hydroxylase 0.0081 0.0484 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0022 0.0073
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0227 0.0733
Onchocerca volvulus 0.0043 0.0216 0.0291
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0052 0.015
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.016 0.051
Trypanosoma cruzi UDP-galactopyranose mutase 0.0234 0.1556 0.5169
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0025
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0306 0.0305
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0154 0.0207
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.003 0.0126 0.0221
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0025 0.0061
Brugia malayi Pax transcription factor protein 2 0.0267 0.1783 0.2404
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0216 0.0389
Echinococcus multilocularis ubiquinone biosynthesis monooxygenase COQ6 0.0081 0.0484 0.0484
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0016 0.0015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0061 0.018
Mycobacterium ulcerans FAD-dependent oxidoreductase 0.0081 0.0484 0.0888
Brugia malayi glutathione reductase 0.0037 0.0178 0.0239
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.003 0.0126 0.0317
Echinococcus multilocularis tumor protein p63 0.0343 0.2316 0.2315
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0016 0.003
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0046 0.0128
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0199 0.0267
Toxoplasma gondii FAD binding domain-containing protein 0.0081 0.0484 0.1592
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.003 0.0126 0.0317
Echinococcus multilocularis pyruvate kinase 0.0021 0.0061 0.0061
Treponema pallidum heat shock protein 90 0.0028 0.011 0.0344
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0133 0.0132
Trypanosoma brucei Heat shock protein 83, putative 0.0035 0.016 0.051
Mycobacterium ulcerans pyruvate kinase 0.004 0.0199 0.0356
Echinococcus multilocularis heat shock protein 0.0035 0.016 0.0159
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0306 0.0996
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0022 0.0049
Schistosoma mansoni pyruvate kinase 0.0021 0.0061 0.0061
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0007 0.0024
Trypanosoma brucei heat shock protein, putative 0.0035 0.016 0.051
Trypanosoma brucei heat shock protein, putative 0.0035 0.016 0.051
Toxoplasma gondii FAD binding domain-containing protein 0.0081 0.0484 0.1592
Loa Loa (eye worm) doublecortin family protein 0.002 0.0059 0.0078
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0991 0.6849 0.6849
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0021 0.0045
Echinococcus multilocularis 0.003 0.0126 0.0125
Trichomonas vaginalis rotamase, putative 0.0033 0.0149 0.0495
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0061 0.018
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0178 0.0457
Loa Loa (eye worm) hypothetical protein 0.0021 0.0061 0.0081
Schistosoma mansoni loxhd1 0.002 0.0059 0.0058
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0022 0.0049
Giardia lamblia Heat shock protein HSP 90-alpha 0.0035 0.016 0.051
Echinococcus granulosus dnaJ subfamily B 0.0421 0.2864 0.2864
Schistosoma mansoni endoplasmin 0.0035 0.016 0.0159
Trypanosoma brucei trypanothione reductase 0.0037 0.0178 0.0569
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0025
Trypanosoma brucei heat shock protein, putative 0.0035 0.016 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0227 0.0756
Giardia lamblia hypothetical protein 0.008 0.0479 0.1573
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.0484 0.1592
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0016 0.002
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0054 0.0072
Echinococcus multilocularis protein MICAL 3 0.0081 0.0484 0.0484
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0306 0.0996
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.003 0.0126 0.0317
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0306 0.1018
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0059 0.0058
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0833 0.0833
Trichomonas vaginalis endoplasmin, putative 0.0021 0.0066 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0084 0.028
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0056 0.0055
Plasmodium vivax RNA helicase-1, putative 0.0441 0.3004 1
Echinococcus granulosus GPCR family 2 0.0016 0.0026 0.0025
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0227 0.0705
Echinococcus multilocularis GPCR, family 2 0.0016 0.0026 0.0025
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0181 0.0181
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.018
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0261 0.0351
Onchocerca volvulus 0.0033 0.015 0.0202
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0306 0.0996
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0061 0.0081
Trypanosoma brucei heat shock protein, putative 0.0035 0.016 0.051
Entamoeba histolytica SWIRM domain protein 0.008 0.0479 0.1547
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0216 0.0291
Loa Loa (eye worm) hypothetical protein 0.0033 0.015 0.0202
Echinococcus granulosus tar DNA binding protein 0.0131 0.0833 0.0833
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.018
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0061 0.01
Trypanosoma brucei heat shock protein, putative 0.0035 0.016 0.051
Leishmania major cytochrome p450-like protein 0.0058 0.0323 0.1052
Brugia malayi Hsp90 protein 0.0014 0.0016 0.0021
Echinococcus granulosus protein MICAL 3 0.0081 0.0484 0.0484
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0021 0.0045
Leishmania major hypothetical protein, conserved 0.0081 0.0484 0.1592
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.003 0.0126 0.0221
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0021 0.002
Brugia malayi Pre-SET motif family protein 0.0033 0.015 0.0202
Plasmodium falciparum eukaryotic initiation factor 4A 0.0441 0.3004 1
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0441 0.3004 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.0022 0.0021
Trypanosoma brucei kynurenine 3-monooxygenase, putative 0.0081 0.0484 0.1592
Loa Loa (eye worm) hypothetical protein 0.002 0.0059 0.0078
Echinococcus multilocularis pyruvate kinase 0.004 0.0199 0.0198
Mycobacterium tuberculosis Possible oxidoreductase 0.0081 0.0484 0.1277
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.018
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.003 0.0126 0.0317
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0059 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.015 0.0149
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.016 0.0481
Plasmodium vivax heat shock protein 90, putative 0.0014 0.0016 0.0031
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0149 0.0443
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0026 0.0062
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0021 0.0045
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0579 0.363
Trypanosoma cruzi cytochrome P450, putative 0.0058 0.0323 0.1052
Onchocerca volvulus 0.0149 0.096 0.1294
Loa Loa (eye worm) hypothetical protein 0.0149 0.096 0.1294
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0052 0.015
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0149 0.0472
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0022 0.0073
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0052 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0164 0.0544
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0026 0.0062
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.016 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0164 0.0544
Plasmodium vivax glutathione reductase, putative 0.0037 0.0178 0.0569
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0012 0.0041
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0052 0.0052
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0154 0.0207
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0007 0.0009
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0306 0.2061 0.6852
Entamoeba histolytica hypothetical protein 0.0035 0.0165 0.0497
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.003 0.0126 0.0221
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.018
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0227 0.0226
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0199 0.0267
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.004 0.0199 0.0267
Leishmania major pyruvate kinase 0.004 0.0199 0.0639
Leishmania major UDP-galactopyranose mutase 0.0234 0.1556 0.5169
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.003 0.0126 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0154 0.0513
Plasmodium vivax heat shock protein 86, putative 0.0035 0.016 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0021 0.0069
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.0833 0.1123
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0306 0.0996
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.0931 0.3084
Plasmodium falciparum endoplasmin, putative 0.0021 0.0066 0.0196
Leishmania major eukaryotic initiation factor 4a, putative 0.0441 0.3004 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0512 0.1353
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0034 0.0152 0.0204
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0579 0.1531
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0441 0.3004 0.3004
Loa Loa (eye worm) pax transcription factor protein 2 0.0267 0.1783 0.2404
Echinococcus multilocularis pyruvate kinase 0.004 0.0199 0.0198
Mycobacterium leprae putative cytochrome p450 0.003 0.0126 0.0677
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0012 0.0041
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0021 0.0045
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0025 0.0061
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0234 0.1556 0.5169
Leishmania major lanosterol 14-alpha-demethylase, putative 0.003 0.0126 0.0396
Echinococcus granulosus expressed protein 0.0034 0.0154 0.0153
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0059 0.0058
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0149 0.0472
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0227 0.0305
Trypanosoma brucei heat shock protein, putative 0.0035 0.016 0.051
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.003 0.0126 0.0317
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.003 0.0126 0.0221
Onchocerca volvulus 0.006 0.0339 0.0456
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0261 0.0351
Echinococcus multilocularis pyruvate kinase 0.0032 0.0139 0.0139
Trypanosoma cruzi cytochrome P450, putative 0.0058 0.0323 0.1052
Echinococcus granulosus death domain containing protein 0.0014 0.0016 0.0015
Leishmania major hypothetical protein, conserved 0.0081 0.0484 0.1592
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.015 0.0149
Giardia lamblia GTOR 0.0044 0.0227 0.0733
Chlamydia trachomatis pyruvate kinase 0.004 0.0199 0.1236
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0025 0.0061
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0061 0.0204
Brugia malayi heat shock protein 90 0.0035 0.016 0.0215
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0028 0.011 0.2163
Brugia malayi Death domain containing protein 0.0014 0.0016 0.002
Schistosoma mansoni cpg binding protein 0.006 0.0339 0.0338
Trypanosoma cruzi cytochrome p450-like protein, putative 0.003 0.0126 0.0396
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.003 0.0126 0.0317
Loa Loa (eye worm) hypothetical protein 0.008 0.0479 0.0645
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0441 0.3004 0.3004
Loa Loa (eye worm) endoplasmin 0.0035 0.016 0.0215
Plasmodium falciparum heat shock protein 90, putative 0.0014 0.0016 0.0031
Brugia malayi hypoxia-induced factor 1 0.0179 0.1169 0.1576
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0306 0.0305
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0227 0.0733
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0165 0.0164
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0268 0.0267
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0026 0.0034
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0049 0.0261 0.0351
Mycobacterium ulcerans oxidoreductase 0.0081 0.0484 0.0888
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.003 0.0126 0.0317
Mycobacterium ulcerans oxidoreductase 0.0234 0.1556 0.2882
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.003 0.0126 0.0396
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0303 0.0303
Brugia malayi cytochrome P450 0.003 0.0126 0.0169
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.003 0.0126 0.0317
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0149 0.0472
Schistosoma mansoni rab6-interacting 0.002 0.0059 0.0058
Trichomonas vaginalis heat shock protein, putative 0.0014 0.0016 0.0055
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0016 0.002
Schistosoma mansoni heat shock protein 0.0014 0.0016 0.0016
Entamoeba histolytica SWIRM domain protein 0.008 0.0479 0.1547
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0061 0.018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0084 0.0281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0147 0.0491
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.003 0.0126 0.0317
Echinococcus granulosus heat shock protein 90 0.0028 0.011 0.011
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0441 0.3004 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0026 0.0025
Entamoeba histolytica hypothetical protein 0.0035 0.0165 0.0497
Brugia malayi Doublecortin family protein 0.002 0.0059 0.0078
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0339 0.0456
Schistosoma mansoni cpg binding protein 0.0064 0.0363 0.0362
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0026 0.0062
Echinococcus multilocularis expressed protein 0.0034 0.0154 0.0153
Schistosoma mansoni endoplasmin 0.0035 0.016 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0021 0.0069
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0007 0.0006
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0017 0.0016
Schistosoma mansoni hypothetical protein 0.0016 0.0026 0.0025
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0061 0.0144
Brugia malayi hypothetical protein 0.0149 0.096 0.1294
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0479 0.1593
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.003 0.0126 0.0396
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0323 0.0434
Loa Loa (eye worm) hypothetical protein 0.0028 0.0113 0.0152
Schistosoma mansoni single-minded 0.0058 0.0321 0.032
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0059 0.0058
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0227 0.0226
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.003 0.0126 0.0221
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0015 0.0022 0.0028
Mycobacterium ulcerans oxidoreductase 0.0081 0.0484 0.0888
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0026 0.0025
Onchocerca volvulus 0.005 0.0268 0.036
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0227 0.0733
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0512 0.3197
Trypanosoma cruzi heat shock protein 85, putative 0.0028 0.011 0.0344
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0926 0.1248
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0012 0.0041
Brugia malayi hypothetical protein 0.002 0.0059 0.0078
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.018
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0306 0.1018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0147 0.0491
Schistosoma mansoni ap endonuclease 0.0019 0.0052 0.0052
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0012 0.0041
Plasmodium vivax pyruvate kinase 2, putative 0.0021 0.0061 0.0181
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0512 0.1353
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0579 0.1531
Trichomonas vaginalis rotamase, putative 0.0034 0.0154 0.0513
Brugia malayi PAS domain containing protein 0.0058 0.0321 0.0432
Schistosoma mansoni polycystin 1-related 0.002 0.0059 0.0058
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0306 0.0996
Loa Loa (eye worm) hypothetical protein 0.0081 0.0484 0.0653
Loa Loa (eye worm) hypothetical protein 0.0315 0.2118 0.2857
Loa Loa (eye worm) hypothetical protein 0.0028 0.0114 0.0152
Mycobacterium ulcerans hypothetical protein 0.0081 0.0484 0.0888
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0199 0.0267
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0216 0.0215
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.003 0.0029
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.003 0.0126 0.0317
Brugia malayi Pre-SET motif family protein 0.0225 0.1489 0.2009
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0063 0.0188
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0026 0.0025
Echinococcus granulosus heat shock protein 0.0035 0.016 0.0159
Toxoplasma gondii heat shock protein 75, putative 0.0014 0.0016 0.0031
Echinococcus multilocularis geminin 0.0348 0.2354 0.2353
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0833 0.0833
Plasmodium vivax pyruvate kinase, putative 0.004 0.0199 0.0639
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0007 0.0024
Plasmodium falciparum glutathione reductase 0.0037 0.0178 0.0569
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0052 0.015
Loa Loa (eye worm) CYP4Cod1 0.0058 0.0323 0.0434
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0052 0.0121
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.003 0.0126 0.0396
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.016 0.0481
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0028 0.011 0.0344
Onchocerca volvulus 0.002 0.0059 0.0078
Schistosoma mansoni lipoxygenase 0.0057 0.0315 0.0314
Loa Loa (eye worm) hypothetical protein 0.1071 0.7411 1
Leishmania major eukaryotic initiation factor 4a, putative 0.0441 0.3004 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0052 0.015
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0199 0.0639
Plasmodium vivax heat shock protein, putative 0.0014 0.0016 0.0031
Mycobacterium tuberculosis Possible oxidoreductase 0.0234 0.1556 0.4148
Giardia lamblia Pyruvate kinase 0.004 0.0199 0.0639
Loa Loa (eye worm) hypothetical protein 0.0441 0.3004 0.4053
Leishmania major mitochondrial DNA polymerase beta 0.0306 0.2061 0.6852
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0218 0.0704
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0182 0.0605
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0303 0.0303
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0012 0.0041
Plasmodium falciparum thioredoxin reductase 0.0037 0.0178 0.0569
Brugia malayi MAP kinase sur-1 0.0056 0.0306 0.0411
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Echinococcus granulosus nuclear factor of activated T cells 5 0.0218 0.1441 0.144
Schistosoma mansoni rab6-interacting 0.002 0.0059 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0147 0.0491
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.018
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0147 0.0468
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.1046 0.2782
Trypanosoma brucei unspecified product 0.0021 0.0061 0.018
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.003 0.0126 0.0317
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0028 0.011 0.011
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.003 0.0126 0.0221
Echinococcus multilocularis pyruvate kinase 0.0021 0.0061 0.0061
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.003 0.0126 0.0317
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.003 0.0126 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0147 0.0491
Echinococcus granulosus heat shock protein 90 0.0035 0.016 0.0159
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.003 0.0126 0.0221
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0016 0.0015
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.003 0.0126 0.0221
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0021 0.002
Mycobacterium ulcerans hypothetical protein 0.0161 0.1046 0.1933
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0315 0.0314
Toxoplasma gondii histone lysine-specific demethylase 0.0234 0.1556 0.5169
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Plasmodium vivax SET domain protein, putative 0.0033 0.015 0.0477
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0781 0.5382 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0016 0.003
Mycobacterium leprae possibleputative FAD-linked oxidoreductase 0.0081 0.0484 0.3014
Echinococcus granulosus endoplasmin 0.0028 0.011 0.011
Plasmodium falciparum heat shock protein 90, putative 0.0014 0.0016 0.0031
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.0113 0.0324
Brugia malayi hypothetical protein 0.002 0.0059 0.0078
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0061 0.0081
Echinococcus multilocularis RUN 0.002 0.0059 0.0058
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0059 0.0058
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.0022 0.0021
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0199 0.0513
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0479 0.1593
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0164 0.0522
Leishmania major DNA polymerase kappa, putative 0.0021 0.0061 0.018
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0026 0.0062
Echinococcus granulosus lysine specific histone demethylase 1A 0.0991 0.6849 0.6849
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0164 0.0522
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0149 0.0472
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0012 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0303 0.0303
Plasmodium falciparum pyruvate kinase 2 0.0021 0.0061 0.0181
Brugia malayi hypothetical protein 0.0194 0.1274 0.1718
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0061 0.018
Brugia malayi Cytochrome P450 family protein 0.0058 0.0323 0.0434
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0323 0.0434
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0026 0.0034
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0026 0.0034
Echinococcus granulosus RUN 0.002 0.0059 0.0058
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0028 0.011 0.0577
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0199 0.0267
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0234 0.1556 1
Loa Loa (eye worm) hypothetical protein 0.0234 0.1556 0.2099
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0015 0.0022 0.0073
Chlamydia trachomatis monooxygenase 0.0081 0.0484 0.308
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0026 0.0034
Echinococcus multilocularis endoplasmin 0.0028 0.011 0.011
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0061 0.006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0026 0.0034
Onchocerca volvulus 0.0015 0.0022 0.0028
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0512 0.1353
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0022 0.0071 0.0414
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.003 0.0126 0.0221
Schistosoma mansoni ap endonuclease 0.0019 0.0052 0.0052
Mycobacterium ulcerans membrane-associated oxidoreductase 0.0081 0.0484 0.0888
Loa Loa (eye worm) glutathione reductase 0.0037 0.0178 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0118 0.0393
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0022 0.0073
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0931 0.3084
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.0022 0.0021
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0059 0.0172
Echinococcus multilocularis tar DNA binding protein 0.0131 0.0833 0.0833
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0026 0.0062
Onchocerca volvulus 0.0267 0.1783 0.2404
Onchocerca volvulus 0.0256 0.1706 0.2302
Brugia malayi Cytochrome P450 family protein 0.0058 0.0323 0.0434
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0012 0.0041
Toxoplasma gondii heat shock protein HSP90 0.0035 0.016 0.051
Giardia lamblia Grp94/Hsp90 0.0028 0.011 0.0344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0147 0.0491
Giardia lamblia Pyruvate kinase 0.0021 0.0061 0.0181
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0052 0.015
Plasmodium vivax FAD-dependent monooxygenase, putative 0.0081 0.0484 0.1592
Toxoplasma gondii exonuclease III APE 0.0019 0.0052 0.015
Trypanosoma brucei pyruvate kinase 1 0.004 0.0199 0.0639
Loa Loa (eye worm) pyruvate kinase 0.004 0.0199 0.0267
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0052 0.0084
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0441 0.3004 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0021 0.0045
Echinococcus multilocularis protoporphyrinogen oxidase 0.0234 0.1556 0.1556
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0441 0.3004 0.3004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0021 0.0069
Giardia lamblia DINP protein human, muc B family 0.0021 0.0061 0.018
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0028 0.011 0.0276
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0306 0.0411
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0012 0.0041
Echinococcus multilocularis heat shock protein 90 0.0028 0.011 0.011
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0007 0.0006
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0021 0.0027
Schistosoma mansoni hypothetical protein 0.0016 0.0026 0.0025
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Echinococcus granulosus ubiquinone biosynthesis monooxygenase COQ6 0.0081 0.0484 0.0484
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0306 0.0305
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.1489 0.2009
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.015 0.0149
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.003 0.0126 0.0317
Mycobacterium tuberculosis Probable oxidoreductase 0.0081 0.0484 0.1277
Loa Loa (eye worm) histone methyltransferase 0.002 0.0056 0.0074
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0022 0.0073
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0306 0.0996
Trypanosoma cruzi heat shock protein 90, putative 0.0035 0.016 0.051
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.003 0.0126 0.0221
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0058 0.0323 0.0587
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.003 0.0126 0.0221
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0061 0.006
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0021 0.0045
Mycobacterium leprae Conserved hypothetical protein 0.003 0.0126 0.0677
Echinococcus granulosus Ankyrin 0.0014 0.0017 0.0016
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0052 0.0174
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.2061 0.6852
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0014 0.0016 0.0016
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0014 0.0016 0.0016
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0014 0.0016 0.0021
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0061 0.006
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0441 0.3004 0.4053
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0227 0.0733
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0052 0.015
Leishmania major heat shock protein, putative 0.0014 0.0016 0.0031
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0056 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.015 0.0149
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Loa Loa (eye worm) RNA binding protein 0.0131 0.0833 0.1123
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.016 0.051
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0238 0.1582 0.5255
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.015 0.0149
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0026 0.0025
Trichomonas vaginalis heat shock protein, putative 0.0028 0.011 0.0368
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0022 0.0073
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0441 0.3004 0.3004
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.003 0.0126 0.0221
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0026 0.0062
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.003 0.0126 0.0221
Leishmania major cytochrome p450-like protein 0.003 0.0126 0.0396
Onchocerca volvulus 0.1071 0.7411 1
Trypanosoma brucei protein kinase, putative 0.0056 0.0306 0.0996
Loa Loa (eye worm) hypothetical protein 0.0991 0.6849 0.9242
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0061 0.0144
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0512 0.1353
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0015 0.0022 0.0073
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0016 0.0015
Schistosoma mansoni DNA polymerase eta 0.0021 0.0061 0.006
Toxoplasma gondii thioredoxin reductase 0.0037 0.0178 0.0569
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.003 0.0126 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0084 0.0281
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Plasmodium vivax endoplasmin, putative 0.0035 0.016 0.051
Schistosoma mansoni hypothetical protein 0.002 0.0059 0.0058
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0441 0.3004 1
Toxoplasma gondii SWIRM domain-containing protein 0.008 0.0479 0.1573
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0061 0.018
Brugia malayi isocitrate dehydrogenase 0.0016 0.0026 0.0034
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0199 0.0639
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0441 0.3004 1
Brugia malayi RNA binding protein 0.0131 0.0833 0.1123
Brugia malayi hypothetical protein 0.0234 0.1556 0.2099
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.003 0.0126 0.0317
Loa Loa (eye worm) pyruvate kinase 0.004 0.0199 0.0267
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0931 0.3084
Chlamydia trachomatis protoporphyrinogen oxidase 0.0234 0.1556 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0164 0.0522
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0113 0.0152
Echinococcus multilocularis heat shock protein 90 0.0035 0.016 0.0159
Giardia lamblia Heat shock protein HSP 90-alpha 0.0028 0.011 0.0344
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0547 0.3742 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0026 0.005
Plasmodium falciparum FAD-dependent monooxygenase, putative 0.0081 0.0484 0.1592
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0084 0.0281
Schistosoma mansoni hypothetical protein 0.0014 0.0016 0.0015
Leishmania major protein kinase, putative 0.0016 0.0025 0.0061
Trypanosoma brucei unspecified product 0.0014 0.0016 0.003
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0061 0.015
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0227 0.0733
Brugia malayi SWIRM domain containing protein 0.1071 0.7411 1
Loa Loa (eye worm) cytochrome P450 0.003 0.0126 0.0169
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0234 0.1556 0.5169
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0021 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0102 0.034
Echinococcus granulosus cytochrome P450 2K1 0.003 0.0126 0.0125
Schistosoma mansoni rotamase 0.0034 0.0154 0.0153
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0303 0.0408
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.002
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.003 0.0126 0.0221
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0061 0.018
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Leishmania major protein kinase, putative 0.0016 0.0025 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0147 0.0491
Brugia malayi Endoplasmin precursor 0.0035 0.016 0.0215
Trypanosoma brucei Monooxygenase, putative 0.0081 0.0484 0.1592
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0102 0.034
Schistosoma mansoni heat shock protein 0.0035 0.016 0.0159
Toxoplasma gondii pyruvate kinase PyKII 0.0021 0.0061 0.0181
Schistosoma mansoni hypothetical protein 0.0081 0.0484 0.0484
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.01 0.0334
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0178 0.0569
Plasmodium vivax hypothetical protein, conserved 0.0234 0.1556 0.5169
Trichomonas vaginalis set domain proteins, putative 0.0256 0.1705 0.5677
Mycobacterium ulcerans hypothetical protein 0.0081 0.0484 0.0888
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0066 0.022
Mycobacterium ulcerans FAD-linked oxidoreductase 0.0081 0.0484 0.0888
Echinococcus granulosus dna polymerase kappa 0.0021 0.0061 0.006
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.003 0.0126 0.0317
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0199 0.0267
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0012 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0227 0.0756
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.082 0.0819
Schistosoma mansoni cytochrome P450 0.003 0.0126 0.0125
Brugia malayi SWIRM domain containing protein 0.008 0.0479 0.0645
Trypanosoma cruzi UDP-galactopyranose mutase 0.0234 0.1556 0.5169
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0484 0.1592
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0026 0.0062
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0016 0.002
Schistosoma mansoni hypothetical protein 0.0348 0.2354 0.2353
Mycobacterium ulcerans dehydrogenase 0.0234 0.1556 0.2882
Toxoplasma gondii Hsp90 domain-containing protein 0.0014 0.0016 0.0031
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.016 0.051
Plasmodium falciparum heat shock protein 90 0.0035 0.016 0.051
Schistosoma mansoni aryl hydrocarbon receptor 0.0058 0.0321 0.032
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0724 0.2392
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0181 0.0181
Schistosoma mansoni amine oxidase 0.0234 0.1556 0.1556
Echinococcus granulosus eukaryotic initiation factor 4A 0.0441 0.3004 0.3004
Plasmodium vivax hypothetical protein, conserved 0.0234 0.1556 0.5169
Echinococcus granulosus single minded 2 0.0043 0.0216 0.0215
Trypanosoma brucei heat shock protein, putative 0.0035 0.016 0.051
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0781 0.5382 1
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0234 0.1556 0.1556
Trypanosoma brucei heat shock protein 84, putative 0.0014 0.0016 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0164 0.0544
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0022 0.0073
Mycobacterium ulcerans monoamine oxidase 0.0234 0.1556 0.2882
Loa Loa (eye worm) heat shock protein 75 0.0014 0.0016 0.0021
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.008 0.0479 0.0478
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0218 0.0704
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0052 0.015
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0061 0.01
Brugia malayi MH2 domain containing protein 0.0144 0.0926 0.1248
Trypanosoma cruzi heat shock protein 90, putative 0.0021 0.006 0.0177
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0178 0.0239
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.0022 0.0021
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0052 0.0052
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0012 0.0041
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0512 0.1353
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0021 0.0069
Trypanosoma brucei heat shock protein, putative 0.0035 0.016 0.051
Loa Loa (eye worm) TAR-binding protein 0.0131 0.0833 0.1123
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0303 0.0303
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0303 0.0303
Echinococcus granulosus cpg binding protein 0.0064 0.0363 0.0362
Plasmodium falciparum pyruvate kinase 0.004 0.0199 0.0639
Trypanosoma cruzi Monooxygenase, putative 0.0081 0.0484 0.1592
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0012 0.0041
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0061 0.018
Echinococcus multilocularis cpg binding protein 0.0064 0.0363 0.0362
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0306 0.0305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0021 0.0069
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0227 0.0705
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0012 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0012 0.0041
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0234 0.1556 0.5169
Mycobacterium tuberculosis Possible oxidoreductase 0.0081 0.0484 0.1277
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0178 0.0569
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0234 0.1556 0.2882
Schistosoma mansoni hypothetical protein 0.0348 0.2354 0.2353
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0084 0.028
Entamoeba histolytica hypothetical protein 0.008 0.0479 0.1547
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0833 0.0833
Leishmania major cytochrome p450-like protein 0.003 0.0126 0.0396
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Toxoplasma gondii hypothetical protein 0.0049 0.0263 0.0852
Mycobacterium ulcerans hypothetical protein 0.0081 0.0484 0.0888
Entamoeba histolytica hypothetical protein 0.0035 0.0165 0.0497
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0165 0.0164
Mycobacterium tuberculosis Probable oxidoreductase 0.0081 0.0484 0.1277
Schistosoma mansoni hypothetical protein 0.0421 0.2864 0.2864
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0833 0.0833
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0007 0.0006
Schistosoma mansoni cpg binding protein 0.0064 0.0363 0.0362
Trypanosoma cruzi heat shock protein 90, putative 0.0028 0.011 0.0344
Loa Loa (eye worm) pyruvate kinase 0.004 0.0199 0.0267
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0199 0.0639
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0284 0.0924
Echinococcus multilocularis dnaJ subfamily B 0.0421 0.2864 0.2864
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0306 0.1018
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0061 0.018
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0026 0.0062
Loa Loa (eye worm) cytochrome P450 family protein 0.011 0.0687 0.0926
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.008 0.0479 0.0478
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0061 0.006
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0234 0.1556 0.5169
Schistosoma mansoni amine oxidase 0.0234 0.1556 0.1556
Loa Loa (eye worm) hypothetical protein 0.0991 0.6849 0.9242
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0441 0.3004 0.8025
Loa Loa (eye worm) hypoxia-induced factor 1 0.0179 0.1169 0.1576
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.003 0.0029
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.003 0.0126 0.0317
Brugia malayi Thioredoxin reductase 0.0037 0.0178 0.0239
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0303 0.0408
Trypanosoma brucei unspecified product 0.0014 0.0016 0.003
Schistosoma mansoni heat shock protein 0.0035 0.016 0.0159
Schistosoma mansoni monoxygenase 0.0081 0.0484 0.0484
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0165 0.0164
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0441 0.3004 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.003 0.0126 0.0317
Echinococcus multilocularis dna polymerase eta 0.0021 0.0061 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0227 0.0756
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0199 0.0661
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.0833 0.1123
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0052 0.015
Echinococcus granulosus pyruvate kinase 0.0021 0.0061 0.0061
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Brugia malayi amine oxidase, flavin-containing family protein 0.0315 0.2118 0.2857
Schistosoma mansoni hypothetical protein 0.0016 0.0026 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0147 0.0491
Brugia malayi CXXC zinc finger family protein 0.006 0.0339 0.0456
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.003 0.0126 0.0221
Plasmodium falciparum protoporphyrinogen oxidase 0.0234 0.1556 0.5169
Brugia malayi Uncoordinated protein 44 0.0014 0.0016 0.002
Schistosoma mansoni microtubule-associated protein tau 0.1441 1 1
Echinococcus granulosus pyruvate kinase 0.0021 0.0061 0.0061
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0152 0.0204
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0022
Trichomonas vaginalis heat shock protein, putative 0.0028 0.011 0.0368
Leishmania major trypanothione reductase 0.0037 0.0178 0.0569
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0026 0.0025
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0052 0.012
Treponema pallidum ATP-dependent RNA helicase 0.0441 0.3004 1
Echinococcus granulosus dna polymerase eta 0.0021 0.0061 0.006
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0028
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0218 0.0704
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0012 0.0041
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0306 0.0996
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0991 0.6849 0.6849
Trypanosoma brucei cytochrome P450, putative 0.0058 0.0323 0.1052
Trichomonas vaginalis heat shock protein, putative 0.0028 0.011 0.0368
Loa Loa (eye worm) hypothetical protein 0.005 0.0268 0.036
Trypanosoma cruzi heat shock protein, putative 0.0014 0.0016 0.0031
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0199 0.0639
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0306 0.1018
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.018
Mycobacterium tuberculosis Probable reductase 0.0085 0.0512 0.1353
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0026 0.0062
Schistosoma mansoni hypothetical protein 0.003 0.0126 0.0125
Trypanosoma cruzi Heat shock protein 83, putative 0.0035 0.016 0.051
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.003 0.0029
Loa Loa (eye worm) heat shock protein 90 0.0035 0.016 0.0215
Trichomonas vaginalis helicase, putative 0.0014 0.0012 0.0041
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0022 0.0049
Schistosoma mansoni hypothetical protein 0.0035 0.0165 0.0164
Schistosoma mansoni pyruvate kinase 0.004 0.0199 0.0198
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0199 0.1152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0164 0.0544
Trichomonas vaginalis heat shock protein, putative 0.0035 0.016 0.0533
Echinococcus multilocularis pyruvate kinase 0.0021 0.0061 0.0061
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0061 0.0204
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0315 0.0314
Echinococcus granulosus pyruvate kinase 0.004 0.0199 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0084 0.0281
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.018
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0306 0.0996
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0102 0.034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0012 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0016 0.003
Echinococcus granulosus pyruvate kinase 0.0021 0.0061 0.0061
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0061 0.006
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0025 0.0061
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0061 0.018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0084 0.028
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0059 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0059 0.0078
Schistosoma mansoni hypothetical protein 0.0034 0.0152 0.0151
Loa Loa (eye worm) hypothetical protein 0.0234 0.1556 0.2099
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0052 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0164 0.0544
Toxoplasma gondii heat shock protein 90, putative 0.0035 0.016 0.051
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0021 0.002
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.003 0.0126 0.0221
Brugia malayi Cytochrome P450 family protein 0.003 0.0126 0.0169
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0306 0.0305
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0052 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.018
Echinococcus granulosus geminin 0.0348 0.2354 0.2353
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.015 0.0149
Brugia malayi eukaryotic initiation factor 4A 0.0441 0.3004 0.4053
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0194 0.1274 0.1718
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0016 0.0015
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0218 0.1441 0.144
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0579 0.1531
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0026 0.0034
Leishmania major pyruvate kinase 0.004 0.0199 0.0639
Leishmania major DNA polymerase eta, putative 0.0021 0.0061 0.018
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0149 0.0472
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0303 0.0303
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0441 0.3004 1
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0306 0.0996
Schistosoma mansoni SWI/SNF complex-related 0.008 0.0479 0.0478
Schistosoma mansoni netrin receptor unc5 0.0014 0.0016 0.0015
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0026 0.0025
Schistosoma mansoni hypothetical protein 0.0016 0.0026 0.0025
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.015 0.0149
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.015 0.0477
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.003 0.0126 0.0317
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0052 0.0944
Echinococcus multilocularis 0.0234 0.1556 0.1556
Echinococcus multilocularis microtubule associated protein 2 0.1441 1 1
Brugia malayi hypothetical protein 0.0035 0.0165 0.0222
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0026 0.0025
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.2061 0.6852
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0227 0.0733
Schistosoma mansoni pyruvate kinase 0.004 0.0199 0.0198
Trichomonas vaginalis adenylate cyclase, putative 0.0015 0.0022 0.0073
Schistosoma mansoni lipoxygenase 0.002 0.0059 0.0058
Echinococcus granulosus pyruvate kinase 0.004 0.0199 0.0198
Entamoeba histolytica hypothetical protein 0.0035 0.0165 0.0497
Leishmania major heat shock protein 83-1 0.0035 0.016 0.051
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.016 0.051
Brugia malayi Cytochrome P450 family protein 0.011 0.0687 0.0926
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0926 0.1248
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0061 0.018
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0022 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0012 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0125 0.0416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.01 0.0334
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0441 0.3004 1
Echinococcus granulosus tumor protein p63 0.0343 0.2316 0.2315
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0227 0.0305
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0441 0.3004 0.3004
Brugia malayi TAR-binding protein 0.0131 0.0833 0.1123
Toxoplasma gondii cytochrome p450 superfamily protein 0.003 0.0126 0.0396
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0218 0.0704

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 0.5858 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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