Detailed information for compound 1619448

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 525.452 | Formula: C20H28N7O8P
  • H donors: 4 H acceptors: 5 LogP: -1.89 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)[C@@H](NP(=O)(OCC1OC(CC1N=[N+]=[N-])n1cc(C)c(=O)[nH]c1=O)O)Cc1ccccc1.N
  • InChi: 1S/C20H25N6O8P.H3N/c1-12-10-26(20(29)22-18(12)27)17-9-14(23-25-21)16(34-17)11-33-35(30,31)24-15(19(28)32-2)8-13-6-4-3-5-7-13;/h3-7,10,14-17H,8-9,11H2,1-2H3,(H,22,27,29)(H2,24,30,31);1H3/t14?,15-,16?,17?;/m0./s1
  • InChiKey: WXKMGLSRTKSAID-KHPDZDGVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0674 0.04 0.2001
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0043 0.0007 0.0036
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0045 0.0008 0.0098
Plasmodium falciparum endoplasmin, putative 0.0063 0.002 0.0321
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0353 0.0201 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.0703 0.0419 0.2073
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.024 0.013 0.0129
Echinococcus multilocularis GPCR, family 2 0.0243 0.0132 0.0131
Brugia malayi hypothetical protein 0.0117 0.0053 0.0266
Schistosoma mansoni hypothetical protein 0.0278 0.0154 0.0384
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0025 0.0072
Plasmodium vivax vivapain-1 0.0117 0.0053 0.2995
Trichomonas vaginalis PIKK family atypical protein kinase 0.1194 0.0725 0.3605
Echinococcus granulosus serine:threonine protein kinase PLK1 0.008 0.003 0.0029
Onchocerca volvulus Cathepsin L homolog 0.0222 0.0119 0.4164
Leishmania major cathepsin L-like protease 0.0222 0.0119 0.0327
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.1202 0.0729 0.3628
Brugia malayi MH2 domain containing protein 0.0045 0.0009 0.0043
Loa Loa (eye worm) heat shock protein 90 0.0103 0.0045 0.0224
Trypanosoma cruzi PAB1-binding protein , putative 0.0181 0.0093 0.0268
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.029 0.0161 0.0783
Brugia malayi nuclear hormone receptor 0.0033 0.0001 0.0003
Echinococcus multilocularis mothers against decapentaplegic 5 0.0102 0.0044 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.1193 0.0724 0.36
Loa Loa (eye worm) glutaminase 2 0.3243 0.2002 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0008 0.0016
Echinococcus multilocularis Smad4 0.0102 0.0044 0.0043
Onchocerca volvulus Cathepsin L homolog 0.0222 0.0119 0.4164
Trichomonas vaginalis PIKK family atypical protein kinase 0.1184 0.0718 0.3572
Entamoeba histolytica hypothetical protein 0.0045 0.0008 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0045 0.0008 0.0016
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1204 0.0731 0.9314
Brugia malayi Papain family cysteine protease containing protein 0.0045 0.0008 0.0041
Entamoeba histolytica hypothetical protein 0.0564 0.0332 0.4456
Loa Loa (eye worm) hypothetical protein 0.0045 0.0008 0.0041
Plasmodium vivax hypothetical protein 0.024 0.013 0.7961
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.024 0.013 0.0373
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0008 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0001 0.0004
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0148 0.0072 0.0208
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.053 0.0311 0.1532
Loa Loa (eye worm) hypothetical protein 0.0063 0.002 0.0098
Schistosoma mansoni hypothetical protein 0.0243 0.0132 0.0329
Schistosoma mansoni thyroid hormone receptor 0.0162 0.0081 0.0201
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0008 0.0018
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0797 0.0477 0.0477
Loa Loa (eye worm) PHD-finger family protein 0.0063 0.002 0.0098
Leishmania major phosphatidylinositol 3-kinase, putative 0.1184 0.0718 0.1979
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0008 0.0018
Echinococcus multilocularis microtubule associated protein 2 0.149 0.0909 0.0908
Brugia malayi N-terminal motif family protein 0.037 0.0211 0.1053
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0258 0.0141 0.1796
Mycobacterium leprae conserved hypothetical protein 0.024 0.013 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Echinococcus granulosus mothers against decapentaplegic 6 0.0045 0.0009 0.0008
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1213 0.0736 0.1846
Plasmodium falciparum phosphatidylinositol 3-kinase 0.029 0.0161 0.3777
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0627 0.0371 0.1834
Echinococcus multilocularis heat shock protein 0.0103 0.0045 0.0044
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Loa Loa (eye worm) hypothetical protein 0.0108 0.0048 0.0238
Loa Loa (eye worm) hypothetical protein 0.0051 0.0012 0.0062
Schistosoma mansoni carbonic anhydrase-related 0.0699 0.0416 0.1042
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.029 0.0161 0.0463
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0758 0.0453 0.5773
Leishmania major cathepsin L-like protease 0.0832 0.0499 0.1375
Trichomonas vaginalis PIKK family atypical protein kinase 0.1213 0.0736 0.3664
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0222 0.0119 0.0593
Plasmodium falciparum serine repeat antigen 1 0.0045 0.0008 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0008 0.0016
Onchocerca volvulus 0.0222 0.0119 0.4164
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Trichomonas vaginalis heat shock protein, putative 0.0103 0.0045 0.0199
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0182 0.0094 0.0093
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0699 0.0416 0.2077
Brugia malayi Papain family cysteine protease containing protein 0.0117 0.0053 0.0264
Echinococcus granulosus heat shock protein 90 0.0082 0.0032 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0694 0.0413 0.2044
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0019 0.0018
Leishmania major cathepsin L-like protease 0.0222 0.0119 0.0327
Echinococcus multilocularis Zinc finger, PHD finger 0.029 0.0161 0.0161
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.129 0.0785 0.392
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0045 0.0008 0.0098
Echinococcus multilocularis mothers against decapentaplegic 6 0.0045 0.0009 0.0008
Toxoplasma gondii FATC domain-containing protein 0.0688 0.0409 0.5573
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0114 0.0051 0.0616
Echinococcus granulosus cathepsin L cysteine proteinase 0.0222 0.0119 0.0118
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0029 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0674 0.04 0.2
Loa Loa (eye worm) hypothetical protein 0.0768 0.0459 0.2293
Brugia malayi Pre-SET motif family protein 0.0061 0.0019 0.0092
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.006 0.0018 0.0051
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.0028 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.1193 0.0724 0.36
Brugia malayi Hsp90 protein 0.0042 0.0007 0.0033
Brugia malayi Putative carbonic anhydrase 5 precursor 0.129 0.0785 0.3919
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1213 0.0736 0.3679
Leishmania major cathepsin L-like protease 0.0832 0.0499 0.1375
Entamoeba histolytica cysteine protease, putative 0.0045 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.037 0.0211 0.1053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Leishmania major carbonic anhydrase-like protein 0.129 0.0785 0.2162
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0688 0.0409 0.2045
Loa Loa (eye worm) hypothetical protein 0.0033 0.0001 0.0004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0008 0.0007
Entamoeba histolytica cysteine protease, putative 0.0045 0.0008 0.0021
Entamoeba histolytica hypothetical protein 0.024 0.013 0.1686
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.0061 0.006
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.029 0.0161 0.2054
Giardia lamblia Cathepsin B precursor 0.0092 0.0037 0.0401
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1194 0.0725 0.9236
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0243 0.0132 0.0131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.0053 0.0241
Loa Loa (eye worm) hypothetical protein 0.0749 0.0447 0.2235
Plasmodium vivax vivapain-2 0.0222 0.0119 0.7244
Echinococcus multilocularis cysteine protease 0.0222 0.0119 0.0118
Loa Loa (eye worm) hypothetical protein 0.0072 0.0025 0.0125
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.024 0.013 0.0129
Onchocerca volvulus 0.0061 0.0019 0.063
Trichomonas vaginalis PIKK family atypical protein kinase 0.1193 0.0724 0.36
Entamoeba histolytica hypothetical protein 0.024 0.013 0.1686
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.024 0.013 0.0373
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0222 0.0119 0.2736
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1213 0.0736 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0243 0.0132 0.0131
Plasmodium falciparum serine repeat antigen 9 0.0045 0.0008 0.0037
Giardia lamblia PHD finger protein 15 0.0063 0.002 0.0156
Brugia malayi Cathepsin L-like precursor 0.015 0.0074 0.0369
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0008 0.0007
Toxoplasma gondii hypothetical protein 0.0699 0.0416 0.5662
Brugia malayi jmjC domain containing protein 0.0076 0.0028 0.0138
Schistosoma mansoni sex comb on midleg homolog 0.0045 0.0008 0.0019
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Schistosoma mansoni kinase 0.0041 0.0006 0.0012
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0044 0.0008 0.0039
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0699 0.0416 0.2078
Loa Loa (eye worm) MH2 domain-containing protein 0.1491 0.091 0.4545
Echinococcus granulosus WGR domain containing protein 0.0034 0.0002 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.1202 0.0729 0.3628
Echinococcus granulosus smad 0.0102 0.0044 0.0043
Brugia malayi Papain family cysteine protease containing protein 0.0222 0.0119 0.0592
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0222 0.0119 0.057
Trichomonas vaginalis endoplasmin, putative 0.0063 0.002 0.0075
Trypanosoma cruzi PAB1-binding protein , putative 0.0181 0.0093 0.0268
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0117 0.0053 0.0131
Giardia lamblia Cathepsin B precursor 0.0092 0.0037 0.0401
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0001 0.0003
Echinococcus granulosus cathepsin b 0.0196 0.0103 0.0102
Loa Loa (eye worm) phosphatidylinositol 3 0.024 0.013 0.0648
Giardia lamblia Heat shock protein HSP 90-alpha 0.0082 0.0032 0.0321
Echinococcus multilocularis cathepsin L cysteine protease 0.0222 0.0119 0.0118
Loa Loa (eye worm) hypothetical protein 0.0449 0.026 0.1299
Mycobacterium ulcerans heat shock protein 90 0.0082 0.0032 0.0157
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.029 0.0161 0.0463
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0045 0.0008 0.0016
Trichomonas vaginalis heat shock protein, putative 0.0082 0.0032 0.0134
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Brugia malayi Cathepsin L-like precursor 0.0222 0.0119 0.0592
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0303 0.0169 0.2209
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0001 0.0003
Schistosoma mansoni cathepsin F (C01 family) 0.015 0.0074 0.0184
Brugia malayi MH1 domain containing protein 0.0056 0.0015 0.0076
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0045 0.0008 0.0019
Echinococcus granulosus polycomb protein SCMH1 0.0045 0.0008 0.0008
Mycobacterium tuberculosis Conserved hypothetical protein 0.024 0.013 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0196 0.0103 0.0255
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0017 0.0016
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0029 0.0028
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0674 0.04 0.04
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.024 0.013 0.7961
Plasmodium falciparum serine repeat antigen 2 0.0045 0.0008 0.0037
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0148 0.0072 0.0208
Brugia malayi glutaminase DH11.1 0.3243 0.2002 1
Loa Loa (eye worm) ctsf protein 0.0222 0.0119 0.0593
Leishmania major cathepsin L-like protease 0.0222 0.0119 0.0327
Trypanosoma brucei heat shock protein, putative 0.0103 0.0045 0.0569
Loa Loa (eye worm) hypothetical protein 0.0196 0.0103 0.0512
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0019 0.0045
Brugia malayi mothers against decapentaplegic homolog 3 0.0045 0.0009 0.0043
Schistosoma mansoni cathepsin F (C01 family) 0.0222 0.0119 0.0296
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.029 0.0161 0.2118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Loa Loa (eye worm) hypothetical protein 0.0222 0.0119 0.0593
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0148 0.0072 0.1604
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0001 0.0004
Loa Loa (eye worm) phosphatidylinositol 3 0.0114 0.0051 0.0256
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.024 0.013 0.1702
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0148 0.0072 0.0072
Toxoplasma gondii isocitrate dehydrogenase 0.0148 0.0072 0.0908
Loa Loa (eye worm) hypothetical protein 0.0243 0.0132 0.0658
Echinococcus granulosus cathepsin L 0.0117 0.0053 0.0052
Echinococcus granulosus microtubule associated protein 2 0.149 0.0909 0.0908
Loa Loa (eye worm) hypothetical protein 0.0045 0.0008 0.0041
Brugia malayi Isocitrate dehydrogenase 0.0148 0.0072 0.0361
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0045 0.0008 0.0037
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.008 0.003 0.0083
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.017 0.0086 0.0431
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1233 0.0749 0.0748
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0114 0.0051 0.0147
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0008 0.0039
Trichomonas vaginalis heat shock protein, putative 0.0082 0.0032 0.0134
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0001 0.0003
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0045 0.0008 0.0041
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0022 0.011
Loa Loa (eye worm) hypothetical protein 0.051 0.0298 0.1489
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0243 0.0132 0.0658
Trichomonas vaginalis PIKK family atypical protein kinase 0.024 0.013 0.0625
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Giardia lamblia GTOR 0.1213 0.0736 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1213 0.0736 1
Trypanosoma brucei heat shock protein, putative 0.0103 0.0045 0.0569
Loa Loa (eye worm) hypothetical protein 0.0072 0.0025 0.0125
Brugia malayi Endoplasmin precursor 0.0103 0.0045 0.0223
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.0119 0.057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0008 0.0016
Schistosoma mansoni smad 0.0045 0.0009 0.002
Echinococcus granulosus peregrin 0.0063 0.002 0.0019
Loa Loa (eye worm) phosphatidylinositol 3 0.1213 0.0736 0.3679
Schistosoma mansoni carbonic anhydrase-related 0.0699 0.0416 0.1042
Brugia malayi Cytochrome P450 family protein 0.0067 0.0022 0.011
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.0061 0.006
Schistosoma mansoni cathepsin B (C01 family) 0.0045 0.0008 0.0019
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Echinococcus granulosus heat shock protein 90 0.0103 0.0045 0.0044
Trypanosoma cruzi heat shock protein 90, putative 0.0082 0.0032 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.1193 0.0724 0.36
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.0119 0.057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Schistosoma mansoni Smad4 0.0045 0.0009 0.002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0008 0.0039
Entamoeba histolytica cysteine protease, putative 0.0045 0.0008 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0001 0.0003
Schistosoma mansoni hypothetical protein 0.0255 0.014 0.0348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Trypanosoma cruzi heat shock protein, putative 0.0042 0.0007 0.0019
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Echinococcus multilocularis cathepsin b 0.0196 0.0103 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0001 0.0004
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0029 0.0142
Plasmodium falciparum phosphatidylinositol 4-kinase 0.024 0.013 0.3007
Onchocerca volvulus 0.0222 0.0119 0.4164
Plasmodium vivax unspecified product 0.0045 0.0008 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0749 0.0447 0.2216
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.008 0.003 0.015
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.037 0.0211 0.7421
Leishmania major hypothetical protein, unknown function 0.024 0.013 0.0357
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.6425 0.3985 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.029 0.0161 0.2138
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0072 0.0025 0.0125
Trypanosoma brucei heat shock protein 90, putative 0.0103 0.0045 0.0569
Brugia malayi cathepsin L-like precursor 0.015 0.0074 0.0369
Loa Loa (eye worm) hypothetical protein 0.0072 0.0025 0.0125
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1213 0.0736 0.9386
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0029 0.0534
Echinococcus granulosus carbonic anhydrase II 0.129 0.0785 0.0784
Giardia lamblia Heat shock protein HSP 90-alpha 0.0103 0.0045 0.0501
Onchocerca volvulus 0.0151 0.0074 0.26
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0222 0.0119 0.057
Plasmodium vivax vivapain-3 0.0117 0.0053 0.2995
Loa Loa (eye worm) hypothetical protein 0.0045 0.0008 0.0041
Brugia malayi Smad1 0.0102 0.0044 0.0217
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0029 0.1414
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0045 0.0008 0.0019
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0688 0.0409 0.1176
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0008 0.0016
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.029 0.0161 0.0161
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0045 0.0008 0.0016
Echinococcus granulosus GPCR family 2 0.0243 0.0132 0.0131
Schistosoma mansoni smad1 5 8 and 0.0102 0.0044 0.0108
Schistosoma mansoni hypothetical protein 0.024 0.013 0.0324
Loa Loa (eye worm) endoplasmin 0.0103 0.0045 0.0224
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0044 0.0008 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0001 0.0004
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0182 0.0094 0.0093
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.053 0.0311 0.1532
Loa Loa (eye worm) hypothetical protein 0.0045 0.0008 0.0042
Schistosoma mansoni hypothetical protein 0.0525 0.0308 0.077
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.129 0.0785 0.1967
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0102 0.0044 0.0108
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0761 0.0454 0.1306
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0353 0.0201 0.1002
Brugia malayi cathepsin Z-like cysteine proteinase 0.0045 0.0008 0.0041
Toxoplasma gondii cathepsin CPC2 0.0045 0.0008 0.0021
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.024 0.013 0.1702
Schistosoma mansoni poly [ADP-ribose] polymerase 0.011 0.0049 0.012
Brugia malayi Cathepsin L-like cysteine proteinase 0.015 0.0074 0.0369
Plasmodium vivax serine-repeat antigen (SERA) 0.0045 0.0008 0.0098
Schistosoma mansoni hypothetical protein 0.0243 0.0132 0.0329
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0008 0.0018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.0119 0.057
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0001 0.0003
Loa Loa (eye worm) fibroinase 0.0222 0.0119 0.0593
Loa Loa (eye worm) isocitrate dehydrogenase 0.0148 0.0072 0.0361
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0045 0.0008 0.0019
Entamoeba histolytica cysteine proteinase, putative 0.0117 0.0053 0.0634
Brugia malayi serine/threonine-protein kinase plk-2 0.008 0.003 0.015
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0045 0.0008 0.0016
Echinococcus multilocularis lysine specific demethylase 5A 0.0076 0.0028 0.0027
Loa Loa (eye worm) hypothetical protein 0.0033 0.0001 0.0004
Echinococcus multilocularis endoplasmin 0.0082 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0033 0.0001 0.0004
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.0008 0.0007
Plasmodium falciparum ataxin-2 like protein, putative 0.0181 0.0093 0.2119
Trypanosoma cruzi cysteine proteinase, putative 0.0117 0.0053 0.0152
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.129 0.0785 0.1967
Echinococcus granulosus carbonic anhydrase 0.0699 0.0416 0.0415
Onchocerca volvulus 0.0045 0.0008 0.0264
Brugia malayi hypothetical protein 0.074 0.0441 0.2204
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0243 0.0132 0.0131
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0627 0.0371 0.1834
Plasmodium vivax endoplasmin, putative 0.0103 0.0045 0.2461
Mycobacterium ulcerans glutaminase 0.3243 0.2002 1
Trypanosoma brucei heat shock protein 84, putative 0.0042 0.0007 0.0084
Loa Loa (eye worm) hypothetical protein 0.015 0.0074 0.0369
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.024 0.013 0.0129
Loa Loa (eye worm) hypothetical protein 0.0033 0.0001 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.1202 0.0729 0.3628
Toxoplasma gondii heat shock protein HSP90 0.0103 0.0045 0.0526
Loa Loa (eye worm) hypothetical protein 0.0699 0.0416 0.2078
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0008 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0434 0.0251 0.1232
Trichomonas vaginalis CAMK family protein kinase 0.008 0.003 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0692 0.0412 0.2037
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0001 0.0003
Onchocerca volvulus 0.0222 0.0119 0.4164
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0148 0.0072 0.5127
Loa Loa (eye worm) hypothetical protein 0.0083 0.0032 0.0161
Trypanosoma brucei cysteine peptidase C (CPC) 0.0092 0.0037 0.0475
Loa Loa (eye worm) phosphatidylinositol kinase 0.024 0.013 0.0648
Trypanosoma brucei heat shock protein 90, putative 0.0103 0.0045 0.0569
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0353 0.0201 0.2657
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0688 0.0409 0.1026
Echinococcus granulosus geminin 0.0255 0.014 0.0139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Entamoeba histolytica cysteine proteinase 2 0.0117 0.0053 0.0634
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0012 0.0011
Echinococcus multilocularis isocitrate dehydrogenase 0.0148 0.0072 0.0072
Schistosoma mansoni carbonic anhydrase-related 0.0699 0.0416 0.1042
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0007 0.0009
Trichomonas vaginalis heat shock protein, putative 0.0063 0.002 0.0075
Schistosoma mansoni glutaminase 0.3243 0.2002 0.5022
Loa Loa (eye worm) hypothetical protein 0.0181 0.0093 0.0467
Schistosoma mansoni hypothetical protein 0.0243 0.0132 0.0329
Toxoplasma gondii cathepsin B 0.0092 0.0037 0.0425
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0196 0.0103 0.0255
Loa Loa (eye worm) mbt repeat family protein 0.0045 0.0008 0.0042
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0045 0.0008 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0001 0.0003
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.029 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0045 0.0008 0.0041
Brugia malayi steroid hormone receptor 0.0033 0.0001 0.0003
Onchocerca volvulus 0.0222 0.0119 0.4164
Trichomonas vaginalis CAMK family protein kinase 0.008 0.003 0.0126
Trypanosoma brucei PAB1-binding protein , putative 0.0181 0.0093 0.1189
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0008 0.0016
Schistosoma mansoni hypothetical protein 0.0081 0.0031 0.0076
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1194 0.0725 0.1997
Echinococcus granulosus cathepsin L cysteine protease 0.0117 0.0053 0.0052
Giardia lamblia Cathepsin B precursor 0.0092 0.0037 0.0401
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0045 0.0009 0.0278
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0001 0.0003
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0685 0.0407 0.5486
Loa Loa (eye worm) nuclear factor I 0.0056 0.0015 0.0077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0019 0.0045
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Schistosoma mansoni cathepsin S (C01 family) 0.0045 0.0008 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.0135 0.0653
Schistosoma mansoni smad1 5 8 and 0.0102 0.0044 0.0108
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.029 0.0161 0.2118
Brugia malayi MH1 domain containing protein 0.0102 0.0044 0.0217
Loa Loa (eye worm) phosphatidylinositol 3 0.024 0.013 0.0648
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.024 0.013 0.1686
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Brugia malayi isocitrate dehydrogenase 0.0148 0.0072 0.0361
Loa Loa (eye worm) hypothetical protein 0.0033 0.0001 0.0004
Echinococcus multilocularis heat shock protein 90 0.0082 0.0032 0.0031
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0045 0.0008 0.0019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.0119 0.057
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0045 0.0008 0.0098
Schistosoma mansoni survival motor neuron protein 0.0151 0.0074 0.0185
Onchocerca volvulus Cathepsin F homolog 0.0222 0.0119 0.4164
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0148 0.0072 0.0921
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1233 0.0749 0.1878
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0051 0.0012 0.0012
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0045 0.0008 0.0019
Brugia malayi MH2 domain containing protein 0.0102 0.0044 0.0217
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Leishmania major cathepsin L-like protease 0.0222 0.0119 0.0327
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.1204 0.0731 0.3635
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1184 0.0718 0.9152
Brugia malayi Papain family cysteine protease containing protein 0.0045 0.0008 0.0041
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1213 0.0736 0.2029
Echinococcus multilocularis 0.024 0.013 0.0129
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1213 0.0736 0.0736
Trichomonas vaginalis conserved hypothetical protein 0.051 0.0298 0.1467
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.029 0.0161 0.0161
Trypanosoma cruzi heat shock protein 90, putative 0.0061 0.0018 0.0052
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0148 0.0072 0.018
Onchocerca volvulus 0.0487 0.0284 1
Trichomonas vaginalis CAMK family protein kinase 0.008 0.003 0.0126
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.001 0.0023
Brugia malayi Cathepsin L-like precursor 0.0072 0.0025 0.0125
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0627 0.0371 0.1834
Loa Loa (eye worm) hypothetical protein 0.0033 0.0001 0.0004
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0051 0.0012 0.0012
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.029 0.0161 0.0403
Schistosoma mansoni cathepsin F (C01 family) 0.0222 0.0119 0.0296
Echinococcus granulosus heat shock protein 0.0103 0.0045 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.0119 0.057
Plasmodium vivax heat shock protein 86, putative 0.0103 0.0045 0.2461
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0042 0.0007 0.0006
Brugia malayi Cathepsin L-like precursor 0.0222 0.0119 0.0592
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0045 0.0008 0.0019
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0042 0.0007 0.0211
Schistosoma mansoni heat shock protein 0.0103 0.0045 0.011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.0053 0.0241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0117 0.0053 0.0674
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0045 0.0008 0.0098
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0148 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.045 0.0261 0.1304
Toxoplasma gondii cathepsin CPL 0.0222 0.0119 0.1549
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0082 0.0032 0.0087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0045 0.0008 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Trypanosoma cruzi major cysteine proteinase, putative 0.0045 0.0008 0.0023
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0029 0.0028
Brugia malayi cathepsin L-like cysteine proteinase 0.0045 0.0008 0.0041
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1233 0.0749 0.2152
Trypanosoma brucei heat shock protein, putative 0.0103 0.0045 0.0569
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0117 0.0053 0.0131
Leishmania major phosphatidylinositol 4-kinase, putative 0.024 0.013 0.0357
Plasmodium falciparum heat shock protein 90 0.0103 0.0045 0.0929
Trichomonas vaginalis set domain proteins, putative 0.0487 0.0284 0.1397
Echinococcus granulosus cathepsin l1 0.0222 0.0119 0.0118
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.015 0.0074 0.0345
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0797 0.0477 0.1196
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.029 0.0161 0.0444
Plasmodium falciparum serine repeat antigen 7 0.0045 0.0008 0.0037
Onchocerca volvulus Serine\/threonine kinase homolog 0.008 0.003 0.1035
Plasmodium vivax SET domain protein, putative 0.0061 0.0019 0.0767
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0768 0.0459 0.2292
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0019 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0001 0.0003
Brugia malayi Cathepsin L-like precursor 0.0222 0.0119 0.0592
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.0028 0.0068
Brugia malayi MH2 domain containing protein 0.1491 0.091 0.4545
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Echinococcus multilocularis cathepsin L 0.0045 0.0008 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0045 0.0008 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0001 0.0004
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.024 0.013 0.0625
Echinococcus granulosus jumonji domain containing protein 0.0088 0.0035 0.0034
Brugia malayi Cathepsin L-like precursor 0.0222 0.0119 0.0592
Brugia malayi cathepsin F-like cysteine proteinase 0.0045 0.0008 0.0041
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.1204 0.0731 0.3635
Schistosoma mansoni hypothetical protein 0.0063 0.002 0.0047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.1193 0.0724 0.36
Loa Loa (eye worm) latrophilin receptor protein 2 0.0243 0.0132 0.0658
Trypanosoma brucei polo-like protein kinase 0.008 0.003 0.0382
Echinococcus granulosus cathepsin L 0.0045 0.0008 0.0007
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.029 0.0161 0.2138
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0001 0.0003
Entamoeba histolytica cysteine proteinase, putative 0.0117 0.0053 0.0634
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0102 0.0044 0.0043
Echinococcus multilocularis PHD finger protein rhinoceros 0.0063 0.002 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0029 0.5
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.051 0.0298 0.0297
Plasmodium vivax unspecified product 0.0117 0.0053 0.2995
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0045 0.0008 0.0019
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0025 0.0072
Loa Loa (eye worm) cysteine protease 0.0222 0.0119 0.0593
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0081 0.0031 0.003
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0045 0.0008 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0081 0.0031 0.003
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0029 0.0302
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Brugia malayi Pre-SET motif family protein 0.0428 0.0247 0.1234
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.029 0.0161 0.0783
Plasmodium vivax hypothetical protein, conserved 0.024 0.013 0.7961
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.015 0.0074 0.0345
Trichomonas vaginalis PIKK family atypical protein kinase 0.077 0.046 0.2279
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0699 0.0416 0.2077
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0019 0.0164
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1213 0.0736 0.0736
Plasmodium falciparum serine repeat antigen 8 0.0045 0.0008 0.0037
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1233 0.0749 0.3742
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.011 0.0049 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Schistosoma mansoni cathepsin C 0.0045 0.0008 0.0019
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0353 0.0201 0.2555
Trichomonas vaginalis PIKK family atypical protein kinase 0.1213 0.0736 0.3664
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0222 0.0119 0.0593
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.006 0.0018 0.0051
Plasmodium vivax serine-repeat antigen (SERA) 0.0045 0.0008 0.0098
Echinococcus multilocularis serine protein kinase ATM 0.0688 0.0409 0.0409
Leishmania major cathepsin L-like protease 0.0832 0.0499 0.1375
Loa Loa (eye worm) hypothetical protein 0.0033 0.0001 0.0004
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0029 0.0302
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0768 0.0459 0.2293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0008 0.0016
Leishmania major phosphatidylinositol kinase, putative 0.024 0.013 0.0357
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0001 0.0004
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0699 0.0416 0.2077
Trichomonas vaginalis PIKK family atypical protein kinase 0.1204 0.0731 0.3635
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0029 0.0142
Trichomonas vaginalis glutaminase, putative 0.3243 0.2002 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0688 0.0409 0.2026
Schistosoma mansoni hypothetical protein 0.051 0.0298 0.0746
Loa Loa (eye worm) hypothetical protein 0.0056 0.0015 0.0077
Trichomonas vaginalis CAMK family protein kinase 0.008 0.003 0.0126
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0196 0.0103 0.0294
Trichomonas vaginalis CAMK family protein kinase 0.008 0.003 0.0126
Brugia malayi heat shock protein 90 0.0103 0.0045 0.0223
Echinococcus granulosus PHD finger protein rhinoceros 0.0063 0.002 0.0019
Echinococcus multilocularis mothers against decapentaplegic 2 0.0045 0.0009 0.0008
Leishmania major hypothetical protein, conserved 0.0181 0.0093 0.0257
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.024 0.013 0.0373
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0008 0.0007
Echinococcus granulosus cathepsin b 0.0196 0.0103 0.0102
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0082 0.0032 0.0031
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0012 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0008 0.0016
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0029 0.1411
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0045 0.0008 0.0041
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0092 0.0037 0.0092
Loa Loa (eye worm) hypothetical protein 0.015 0.0074 0.0369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Brugia malayi PHD-finger family protein 0.0063 0.002 0.0097
Trypanosoma cruzi heat shock protein 85, putative 0.0103 0.0045 0.0128
Giardia lamblia Kinase, PLK 0.008 0.003 0.03
Trypanosoma cruzi cysteine peptidase, putative 0.0832 0.0499 0.1434
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0001 0.0003
Leishmania major cysteine peptidase A (CPA) 0.0222 0.0119 0.0327
Plasmodium falciparum ataxin-2 like protein, putative 0.0181 0.0093 0.2119
Echinococcus granulosus lysine specific demethylase 5A 0.0076 0.0028 0.0027
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1213 0.0736 0.2029
Loa Loa (eye worm) Smad1 0.0102 0.0044 0.0218
Trypanosoma brucei heat shock protein, putative 0.0103 0.0045 0.0569
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.024 0.013 0.1652
Onchocerca volvulus 0.0222 0.0119 0.4164
Trichomonas vaginalis PIKK family atypical protein kinase 0.1202 0.0729 0.3628
Onchocerca volvulus Cathepsin L homolog 0.0045 0.0008 0.0264
Echinococcus multilocularis cathepsin L cysteine protease 0.0222 0.0119 0.0118
Plasmodium falciparum serine repeat antigen 6 0.0045 0.0008 0.0037
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0045 0.0008 0.0019
Treponema pallidum heat shock protein 90 0.0082 0.0032 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Onchocerca volvulus 0.024 0.013 0.4556
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0353 0.0201 0.098
Trypanosoma cruzi polo-like protein kinase, putative 0.008 0.003 0.0086
Schistosoma mansoni jumonji domain containing protein 0.0164 0.0082 0.0205
Trypanosoma cruzi cysteine proteinase, putative 0.0117 0.0053 0.0152
Toxoplasma gondii cathepsin CPC1 0.0045 0.0008 0.0021
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0148 0.0072 0.0072
Trypanosoma cruzi heat shock protein 85, putative 0.0082 0.0032 0.0091
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0699 0.0416 0.2077
Schistosoma mansoni thyroid hormone receptor 0.0162 0.0081 0.0201
Plasmodium falciparum serine repeat antigen 5 0.0045 0.0008 0.0037
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0051 0.0012 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0206 0.0109 0.0108
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0045 0.0008 0.0098
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0627 0.0371 0.1854
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0082 0.0032 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0692 0.0412 0.2037
Brugia malayi Papain family cysteine protease containing protein 0.0117 0.0053 0.0264
Echinococcus multilocularis polycomb protein SCMH1 0.0045 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.1202 0.0729 0.3628
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0206 0.0109 0.0108
Entamoeba histolytica hypothetical protein 0.024 0.013 0.1686
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0082 0.0032 0.167
Echinococcus granulosus serine protein kinase ATM 0.0688 0.0409 0.0409
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.024 0.013 0.7961
Leishmania major hypothetical protein, conserved 0.5854 0.3629 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.0119 0.057
Echinococcus multilocularis peregrin 0.0063 0.002 0.0019
Toxoplasma gondii LsmAD domain-containing protein 0.0181 0.0093 0.12
Schistosoma mansoni hypothetical protein 0.0255 0.014 0.0348
Onchocerca volvulus 0.024 0.013 0.4556
Schistosoma mansoni hypothetical protein 0.0129 0.0061 0.015
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.024 0.013 0.0648
Plasmodium falciparum serine repeat antigen 3 0.0045 0.0008 0.0037
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.024 0.013 0.3007
Schistosoma mansoni hypothetical protein 0.0151 0.0074 0.0185
Trypanosoma cruzi major cysteine proteinase, putative 0.0655 0.0389 0.1117
Echinococcus multilocularis cysteine protease 0.0222 0.0119 0.0118
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.029 0.0161 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0045 0.0008 0.0037
Echinococcus granulosus SAM and MBT domain containing protein 0.0045 0.0008 0.0008
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0222 0.0119 0.2736
Toxoplasma gondii preprocathepsin c precursor, putative 0.0045 0.0008 0.0021
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0797 0.0477 0.0477
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0148 0.0072 0.0072
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0353 0.0201 0.098
Schistosoma mansoni Smad4 0.0045 0.0009 0.002
Echinococcus multilocularis thyroid hormone receptor alpha 0.0162 0.0081 0.008
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0063 0.002 0.0047
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0045 0.0008 0.0098
Loa Loa (eye worm) jmjC domain-containing protein 0.013 0.0061 0.0306
Entamoeba histolytica serine/threonine protein kinase, putative 0.008 0.003 0.032
Trichomonas vaginalis PIKK family atypical protein kinase 0.024 0.013 0.0625
Trichomonas vaginalis PIKK family atypical protein kinase 0.0692 0.0412 0.2037
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0045 0.0008 0.0098
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Loa Loa (eye worm) cathepsin B 0.0092 0.0037 0.0187
Entamoeba histolytica cysteine protease, putative 0.0222 0.0119 0.1534
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0148 0.0072 0.0921
Trichomonas vaginalis PIKK family atypical protein kinase 0.1202 0.0729 0.3628
Brugia malayi FAT domain containing protein 0.051 0.0298 0.1488
Schistosoma mansoni smad1 5 8 and 0.0102 0.0044 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0001 0.0003
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0467 0.0272 0.3616
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.045 0.0261 0.1303
Trichomonas vaginalis PIKK family atypical protein kinase 0.1184 0.0718 0.3572
Echinococcus granulosus poly adp ribose polymerase 2 0.006 0.0018 0.0017
Schistosoma mansoni endoplasmin 0.0103 0.0045 0.011
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0045 0.0008 0.0098
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.0008 0.0007
Echinococcus granulosus histone acetyltransferase MYST2 0.0051 0.0012 0.0012
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.024 0.013 0.0129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Brugia malayi Cathepsin L-like precursor 0.0222 0.0119 0.0592
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Loa Loa (eye worm) glutaminase 0.3243 0.2002 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0045 0.0009 0.0043
Echinococcus granulosus endoplasmin 0.0082 0.0032 0.0031
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0019 0.0018
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0045 0.0008 0.0271
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Echinococcus granulosus survival motor neuron protein 1 0.074 0.0441 0.0441
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.0119 0.057
Entamoeba histolytica hypothetical protein 0.0688 0.0409 0.5519
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0019 0.0045
Loa Loa (eye worm) hypothetical protein 0.0699 0.0416 0.2078
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0627 0.0371 0.1067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0008 0.0016
Loa Loa (eye worm) phosphatidylinositol 3 0.024 0.013 0.0648
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0042 0.0007 0.0006
Schistosoma mansoni heat shock protein 0.0042 0.0007 0.0015
Echinococcus multilocularis cathepsin b 0.0196 0.0103 0.0102
Brugia malayi Papain family cysteine protease containing protein 0.0045 0.0008 0.0041
Leishmania major heat shock protein, putative 0.0042 0.0007 0.0018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.0119 0.057
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0387 0.0222 0.2947
Trichomonas vaginalis CAMK family protein kinase 0.008 0.003 0.0126
Loa Loa (eye worm) carbonic anhydrase 3 0.129 0.0785 0.392
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.029 0.0161 0.0805
Loa Loa (eye worm) hypothetical protein 0.015 0.0074 0.0369
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.1168 0.0708 0.1776
Loa Loa (eye worm) hypothetical protein 0.0177 0.0091 0.0453
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0045 0.0008 0.0016
Trypanosoma brucei Heat shock protein 83, putative 0.0103 0.0045 0.0569
Onchocerca volvulus 0.0222 0.0119 0.4164
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.001 0.0023
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0674 0.04 0.04
Plasmodium falciparum cysteine proteinase falcipain 1 0.0117 0.0053 0.1131
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.024 0.013 0.1652
Loa Loa (eye worm) hypothetical protein 0.0061 0.0019 0.0093
Echinococcus multilocularis heat shock protein 90 0.0103 0.0045 0.0044
Trypanosoma cruzi cysteine peptidase, putative 0.0832 0.0499 0.1434
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.024 0.013 0.0129
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0699 0.0416 0.2077
Schistosoma mansoni microtubule-associated protein tau 0.149 0.0909 0.228
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.011 0.0049 0.0574
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0627 0.0371 0.4995
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0001 0.0003
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0222 0.0119 0.0118
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0627 0.0371 0.1067
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0117 0.0053 0.0152
Loa Loa (eye worm) jmjC domain-containing protein 0.0076 0.0028 0.0139
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0151 0.0074 0.0371
Schistosoma mansoni phosphatidylinositol 4-kinase 0.029 0.0161 0.0403
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0045 0.0008 0.0041
Schistosoma mansoni Smad4 0.0102 0.0044 0.0108
Schistosoma mansoni endoplasmin 0.0103 0.0045 0.011
Trypanosoma brucei carbonic anhydrase-like protein 0.129 0.0785 1
Plasmodium vivax hypothetical protein, conserved 0.0063 0.002 0.0831
Loa Loa (eye worm) hypothetical protein 0.006 0.0018 0.0089
Brugia malayi hypothetical protein 0.0181 0.0093 0.0466
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.024 0.013 0.1702
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.0119 0.057
Echinococcus granulosus mothers against decapentaplegic 5 0.0102 0.0044 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.1204 0.0731 0.3635
Trypanosoma brucei heat shock protein, putative 0.0103 0.0045 0.0569
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0353 0.0201 0.098
Schistosoma mansoni carbonic anhydrase 0.0699 0.0416 0.1042
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0148 0.0072 0.0072
Brugia malayi cathepsin F-like cysteine proteinase 0.0072 0.0025 0.0125
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0196 0.0103 0.0255
Trichomonas vaginalis heat shock protein, putative 0.0082 0.0032 0.0134
Schistosoma mansoni sex comb on midleg homolog 0.0045 0.0008 0.0019
Echinococcus multilocularis carbonic anhydrase 0.0699 0.0416 0.0415
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Trypanosoma cruzi polo-like protein kinase, putative 0.008 0.003 0.0086
Echinococcus multilocularis carbonic anhydrase II 0.129 0.0785 0.0784
Entamoeba histolytica cysteine proteinase 1, putative 0.0117 0.0053 0.0634
Trypanosoma cruzi heat shock protein 85, putative 0.0103 0.0045 0.0128
Entamoeba histolytica cysteine proteinase, putative 0.0117 0.0053 0.0634
Trichomonas vaginalis PIKK family atypical protein kinase 0.1202 0.0729 0.3628
Brugia malayi MH1 domain containing protein 0.0056 0.0015 0.0076
Echinococcus multilocularis survival motor neuron protein 1 0.074 0.0441 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.1204 0.0731 0.3635
Plasmodium falciparum carbonic anhydrase 0.0699 0.0416 1
Trypanosoma brucei heat shock protein, putative 0.0103 0.0045 0.0569
Trypanosoma cruzi target of rapamycin kinase 3 0.1204 0.0731 0.21
Echinococcus multilocularis jumonji domain containing protein 0.0088 0.0035 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.1184 0.0718 0.3572
Trypanosoma cruzi cysteine peptidase, putative 0.0832 0.0499 0.1434
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0072 0.0025 0.0125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0001 0.0004
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0434 0.0251 0.1232
Schistosoma mansoni phosphatidylinositol 4-kinase 0.024 0.013 0.0324
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0001 0.0003
Onchocerca volvulus Alhambra homolog 0.0063 0.002 0.0664
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.029 0.0161 0.0806
Echinococcus granulosus carbonic anhydrase 0.0699 0.0416 0.0415
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0045 0.0008 0.0019
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.045 0.0261 0.026
Entamoeba histolytica heat shock protein 90, putative 0.0103 0.0045 0.0521
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.024 0.013 0.0324
Echinococcus granulosus carbonic anhydrase 0.0699 0.0416 0.0415
Echinococcus granulosus poly ADP ribose polymerase 1 0.011 0.0049 0.0048
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.129 0.0785 0.3919
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.008 0.003 0.0029
Trypanosoma cruzi cysteine peptidase, putative 0.0222 0.0119 0.0341
Loa Loa (eye worm) hypothetical protein 0.0045 0.0008 0.0041
Loa Loa (eye worm) heat shock protein 75 0.0042 0.0007 0.0034
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0092 0.0037 0.0107
Brugia malayi Cathepsin L-like precursor 0.015 0.0074 0.0369
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.024 0.013 0.0324
Brugia malayi nuclear receptor NHR-88 0.0033 0.0001 0.0003
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1213 0.0736 0.9386
Onchocerca volvulus 0.0045 0.0008 0.0271
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0254 0.0139 0.0398
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0029 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.1193 0.0724 0.36
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0006 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0685 0.0407 0.2014
Schistosoma mansoni heat shock protein 0.0103 0.0045 0.011
Brugia malayi mbt repeat family protein 0.0045 0.0008 0.0041
Schistosoma mansoni fkbp-rapamycin associated protein 0.0674 0.04 0.1003
Echinococcus multilocularis carbonic anhydrase 0.0699 0.0416 0.0415
Loa Loa (eye worm) hypothetical protein 0.0699 0.0416 0.2078
Leishmania major cathepsin L-like protease 0.0222 0.0119 0.0327
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.045 0.0261 0.026
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0045 0.0008 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0001 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.1184 0.0718 0.3572
Giardia lamblia Hypothetical protein 0.024 0.013 0.1669
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1213 0.0736 0.2116
Trypanosoma cruzi cysteine protease, putative 0.0117 0.0053 0.0152
Entamoeba histolytica cysteine protease, putative 0.0045 0.0008 0.0021
Brugia malayi mbt repeat family protein 0.0045 0.0008 0.0041
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1213 0.0736 0.2116
Loa Loa (eye worm) hypothetical protein 0.0045 0.0009 0.0043
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0674 0.04 0.1151
Loa Loa (eye worm) hypothetical protein 0.024 0.013 0.0648
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0117 0.0053 0.0674
Toxoplasma gondii target of rapamycin (TOR), putative 0.1202 0.0729 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0254 0.0139 0.0382
Echinococcus multilocularis cathepsin L 0.0117 0.0053 0.0052
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1204 0.0731 0.2014
Loa Loa (eye worm) hypothetical protein 0.0077 0.0029 0.0143
Echinococcus multilocularis SAM and MBT domain containing protein 0.0045 0.0008 0.0008
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0001 0.0004
Loa Loa (eye worm) MH1 domain-containing protein 0.0102 0.0044 0.0218
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0045 0.0008 0.0021
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.024 0.013 0.7961
Schistosoma mansoni smad 0.0102 0.0044 0.0108
Schistosoma mansoni myelin transcription factor 1 myt1 0.0051 0.0012 0.0029
Echinococcus granulosus cathepsin l cysteine peptidase 0.0222 0.0119 0.0118
Loa Loa (eye worm) MBCTL1 0.0051 0.0012 0.0062
Trypanosoma cruzi hypothetical protein, conserved 0.5614 0.3479 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0045 0.0008 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0008 0.0016
Plasmodium vivax vivapain-2 0.0222 0.0119 0.7244
Loa Loa (eye worm) hypothetical protein 0.0033 0.0001 0.0004
Plasmodium vivax ataxin-2 like protein, putative 0.0181 0.0093 0.5611
Plasmodium falciparum phd finger protein, putative 0.0063 0.002 0.0314
Toxoplasma gondii isocitrate dehydrogenase 0.0148 0.0072 0.0908
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0006 0.0007
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0749 0.0447 0.6098
Plasmodium falciparum cysteine proteinase falcipain 3 0.0222 0.0119 0.2736
Brugia malayi MH2 domain containing protein 0.0102 0.0044 0.0217
Brugia malayi Cathepsin L-like precursor 0.0222 0.0119 0.0592
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0092 0.0037 0.0163
Entamoeba histolytica cysteine proteinase, putative 0.0222 0.0119 0.1534
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Brugia malayi cathepsin B-like cysteine proteinase 0.0196 0.0103 0.0512
Brugia malayi cathepsin Z-like cysteine proteinase 0.0045 0.0008 0.0041
Loa Loa (eye worm) MH1 domain-containing protein 0.0045 0.0009 0.0043
Loa Loa (eye worm) phosphatidylinositol 3 0.024 0.013 0.0648
Trypanosoma cruzi Heat shock protein 83, putative 0.0103 0.0045 0.0128
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0082 0.0032 0.167
Loa Loa (eye worm) MH2 domain-containing protein 0.0102 0.0044 0.0218
Giardia lamblia Grp94/Hsp90 0.0082 0.0032 0.0321
Brugia malayi Latrophilin receptor protein 2 0.0243 0.0132 0.0658
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0019 0.0045
Toxoplasma gondii heat shock protein 90, putative 0.0103 0.0045 0.0526
Entamoeba histolytica protein kinase rad3, putative 0.0674 0.04 0.5396
Brugia malayi WGR domain containing protein 0.006 0.0018 0.0088
Brugia malayi Probable ClpP-like protease 0.0077 0.0029 0.0142
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Echinococcus granulosus cathepsin l1 0.015 0.0074 0.0073
Trypanosoma brucei heat shock protein, putative 0.0103 0.0045 0.0569
Entamoeba histolytica heat shock protein 90, putative 0.0103 0.0045 0.0521
Trichomonas vaginalis PIKK family atypical protein kinase 0.1193 0.0724 0.36
Echinococcus multilocularis geminin 0.0255 0.014 0.0139
Echinococcus granulosus TGF beta signal transducer SmadC 0.0102 0.0044 0.0043
Loa Loa (eye worm) phosphatidylinositol 3 0.0734 0.0438 0.2188
Leishmania major phosphatidylinositol 3-kinase, putative 0.029 0.0161 0.0444
Loa Loa (eye worm) hypothetical protein 0.074 0.0441 0.2205
Trypanosoma cruzi cruzipain precursor, putative 0.0832 0.0499 0.1434
Schistosoma mansoni poly [ADP-ribose] polymerase 0.006 0.0018 0.0043
Schistosoma mansoni hypothetical protein 0.0699 0.0416 0.1042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0222 0.0119 0.0118
Trichomonas vaginalis CAMK family protein kinase 0.008 0.003 0.0126
Echinococcus granulosus mothers against decapentaplegic 2 0.0045 0.0009 0.0008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.024 0.013 0.0648
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0117 0.0053 0.0131
Entamoeba histolytica cysteine proteinase, putative 0.015 0.0074 0.092
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0564 0.0332 0.4456
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.024 0.013 0.0373
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0052 0.0013 0.003
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.129 0.0785 0.2255
Entamoeba histolytica cysteine protease, putative 0.0045 0.0008 0.0021
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.051 0.0298 0.0297
Brugia malayi MH1 domain containing protein 0.0102 0.0044 0.0217
Plasmodium vivax unspecified product 0.0072 0.0025 0.1189
Brugia malayi ecdysteroid receptor 0.0033 0.0001 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Trypanosoma brucei heat shock protein, putative 0.0103 0.0045 0.0569
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0045 0.0008 0.0041
Plasmodium falciparum serine repeat antigen 4 0.0045 0.0008 0.0037
Trypanosoma cruzi heat shock protein 90, putative 0.0103 0.0045 0.0128
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.024 0.013 0.0625
Trichomonas vaginalis PIKK family atypical protein kinase 0.1195 0.0725 0.3607
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.024 0.013 0.0648
Loa Loa (eye worm) phosphatidylinositol 3 0.1194 0.0725 0.362
Brugia malayi latrophilin 2 splice variant baaae 0.0525 0.0308 0.1536
Brugia malayi WGR domain containing protein 0.011 0.0049 0.0242
Brugia malayi Calcitonin receptor-like protein seb-1 0.0768 0.0459 0.2292
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.002 0.0178
Schistosoma mansoni serine/threonine protein kinase 0.008 0.003 0.0074
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0148 0.0072 0.0199
Echinococcus multilocularis smad 0.0102 0.0044 0.0043
Loa Loa (eye worm) transcription factor SMAD2 0.1491 0.091 0.4545
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.006 0.0018 0.0017
Onchocerca volvulus 0.015 0.0074 0.2583
Brugia malayi cathepsin L precursor 0.0045 0.0008 0.0041
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0045 0.0008 0.0098
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0353 0.0201 0.0502
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0387 0.0222 0.2944
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1233 0.0749 0.2152
Trichomonas vaginalis PIKK family atypical protein kinase 0.1213 0.0736 0.3664
Trypanosoma brucei poly(adp-ribose) polymerase 0.006 0.0018 0.0226
Giardia lamblia Phosphatidylinositol 4-kinase 0.024 0.013 0.1669
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0428 0.0247 0.1234
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1233 0.0749 0.0748
Echinococcus multilocularis histone acetyltransferase MYST2 0.0051 0.0012 0.0012
Trypanosoma cruzi heat shock protein 85, putative 0.0103 0.0045 0.0128
Echinococcus granulosus poly (ADP ribose) polymerase 0.0034 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0525 0.0308 0.1536
Onchocerca volvulus 0.0222 0.0119 0.4164
Trypanosoma cruzi cysteine peptidase, putative 0.0117 0.0053 0.0152
Echinococcus multilocularis carbonic anhydrase 0.0699 0.0416 0.0415
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0688 0.0409 0.5218
Echinococcus granulosus cysteine protease 0.0117 0.0053 0.0052
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.129 0.0785 0.2255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0674 0.04 0.1981
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0148 0.0072 0.4246
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0092 0.0037 0.0103
Schistosoma mansoni hypothetical protein 0.0243 0.0132 0.0329
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0449 0.026 0.0747
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0243 0.0132 0.0131
Entamoeba histolytica cysteine proteinase, putative 0.0222 0.0119 0.1534
Loa Loa (eye worm) hypothetical protein 0.0045 0.0008 0.0041
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0353 0.0201 0.2657
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.029 0.0161 0.0783
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.002 0.0178
Entamoeba histolytica cysteine protease, putative 0.0045 0.0008 0.0021
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0196 0.0103 0.0255
Brugia malayi jmjC domain containing protein 0.0206 0.0109 0.0543
Schistosoma mansoni cathepsin s 0.0072 0.0025 0.0061
Brugia malayi fibroinase precursor 0.0045 0.0008 0.0041
Brugia malayi Bromodomain containing protein 0.0063 0.002 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.1195 0.0725 0.3607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0045 0.0008 0.0016
Entamoeba histolytica cysteine proteinase, putative 0.0117 0.0053 0.0634
Echinococcus granulosus Smad4 0.0102 0.0044 0.0043

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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