Detailed information for compound 176879

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 566.649 | Formula: C29H38N6O6
  • H donors: 6 H acceptors: 6 LogP: 1.53 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC(C[C@@H](C(=O)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN1CN[C@H](C1=O)Cc1ccc(cc1)O)C
  • InChi: 1S/C29H38N6O6/c1-18(2)12-22(27(30)39)34-28(40)23(13-19-6-4-3-5-7-19)33-25(37)15-31-26(38)16-35-17-32-24(29(35)41)14-20-8-10-21(36)11-9-20/h3-11,18,22-24,32,36H,12-17H2,1-2H3,(H2,30,39)(H,31,38)(H,33,37)(H,34,40)/t22-,23-,24-/m0/s1
  • InChiKey: LLHPWKIBWLLBLR-HJOGWXRNSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Kappa opioid receptor Starlite/ChEMBL References
Homo sapiens opioid receptor, delta 1 Starlite/ChEMBL References
Rattus norvegicus Mu opioid receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Programmed cell death protein 5 homolog Kappa opioid receptor   380 aa 353 aa 23.2 %
Echinococcus granulosus allatostatin A receptor Kappa opioid receptor   380 aa 320 aa 28.1 %
Brugia malayi GnHR receptor homolog Kappa opioid receptor   380 aa 345 aa 20.0 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Kappa opioid receptor   380 aa 387 aa 25.1 %
Onchocerca volvulus Kappa opioid receptor   380 aa 344 aa 24.4 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Kappa opioid receptor   380 aa 335 aa 23.6 %
Schistosoma mansoni rhodopsin-like orphan GPCR Kappa opioid receptor   380 aa 363 aa 22.9 %
Echinococcus multilocularis allatostatin A receptor Kappa opioid receptor   380 aa 319 aa 27.6 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Kappa opioid receptor   380 aa 352 aa 19.3 %
Echinococcus granulosus orexin receptor type 2 Kappa opioid receptor   380 aa 381 aa 23.1 %
Onchocerca volvulus Kappa opioid receptor   380 aa 313 aa 26.8 %
Echinococcus multilocularis neuropeptide receptor Kappa opioid receptor   380 aa 315 aa 26.3 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Kappa opioid receptor   380 aa 313 aa 26.8 %
Echinococcus multilocularis orexin receptor type 2 Kappa opioid receptor   380 aa 381 aa 22.6 %
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Kappa opioid receptor   380 aa 347 aa 22.5 %
Brugia malayi hypothetical protein Kappa opioid receptor   380 aa 319 aa 21.9 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Kappa opioid receptor   380 aa 408 aa 23.5 %
Echinococcus multilocularis growth hormone secretagogue receptor type 1 Kappa opioid receptor   380 aa 306 aa 21.2 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Kappa opioid receptor   380 aa 310 aa 20.0 %
Schistosoma mansoni neuropeptide F-like receptor Mu opioid receptor   398 aa 335 aa 20.6 %
Onchocerca volvulus Mitogen-activated protein kinase kinase kinase 8 homolog Kappa opioid receptor   380 aa 384 aa 20.3 %
Echinococcus granulosus thyrotropin releasing hormone receptor Kappa opioid receptor   380 aa 359 aa 25.3 %
Onchocerca volvulus Phosphoinositide 3-kinase adapter subunit homolog Kappa opioid receptor   380 aa 332 aa 23.5 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Kappa opioid receptor   380 aa 337 aa 25.8 %
Schistosoma japonicum Rhodopsin, putative Kappa opioid receptor   380 aa 352 aa 22.2 %
Echinococcus granulosus neuropeptide receptor Kappa opioid receptor   380 aa 315 aa 26.0 %
Onchocerca volvulus Kappa opioid receptor   380 aa 313 aa 20.8 %
Echinococcus granulosus growth hormone secretagogue receptor type 1 Kappa opioid receptor   380 aa 306 aa 21.2 %
Brugia malayi ORL1-like opioid receptor Kappa opioid receptor   380 aa 335 aa 24.5 %
Onchocerca volvulus Phospholipase d-related homolog Kappa opioid receptor   380 aa 309 aa 19.4 %
Onchocerca volvulus Kappa opioid receptor   380 aa 310 aa 25.5 %
Onchocerca volvulus Kappa opioid receptor   380 aa 403 aa 26.3 %
Brugia malayi hypothetical protein Kappa opioid receptor   380 aa 332 aa 20.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0009 0.0021 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0051 0.0046
Echinococcus multilocularis Smad4 0.0009 0.0027 0.0015
Schistosoma mansoni neuropeptide receptor 0.0009 0.0021 0.001
Giardia lamblia Kinase, NEK 0.0014 0.008 0.5
Schistosoma mansoni hypothetical protein 0.0038 0.0349 0.0399
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0014 0.008 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0051 0.0046
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0771 0.8457 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0021 0.001
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0021 0.0009
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0384 0.0447
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0012 0.0007
Schistosoma mansoni fusion 0.0274 0.296 0.3491
Echinococcus granulosus neuropeptide receptor A26 0.0009 0.0021 0.001
Entamoeba histolytica zinc finger domain containing protein 0.0014 0.008 0.0598
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0009 0.0021 0.001
Onchocerca volvulus 0.0032 0.0282 0.032
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0771 0.8457 1
Leishmania major hypothetical protein, conserved 0.0014 0.008 0.023
Onchocerca volvulus Putative RING finger protein 207 0.0014 0.008 0.008
Brugia malayi CXXC zinc finger family protein 0.0032 0.0282 0.032
Echinococcus multilocularis 0.0014 0.008 0.0068
Schistosoma mansoni histamine h1 receptor 0.0009 0.0021 0.001
Brugia malayi AKH receptor 0.0009 0.0021 0.001
Brugia malayi Inositol-1 0.0041 0.0384 0.0441
Trichomonas vaginalis hypothetical protein 0.0014 0.008 0.0087
Giardia lamblia Hypothetical protein 0.0014 0.008 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0009 0.0021 0.0009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.0046
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0051 0.0039
Brugia malayi MH1 domain containing protein 0.0009 0.0027 0.0017
Onchocerca volvulus Neuropeptide F receptor homolog 0.0009 0.0021 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0051 0.0046
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.0046
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0122 0.011
Echinococcus multilocularis protein dispatched 1 0.0054 0.0525 0.0513
Schistosoma mansoni peter pan-related 0.0014 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0274 0.296 1
Echinococcus granulosus cell growth regulator with ring finger domain 0.0014 0.008 0.008
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0384 0.1263
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0009 0.0021 0.001
Schistosoma mansoni alpha-1 adrenergic receptor 0.0009 0.0021 0.001
Echinococcus granulosus expressed conserved protein 0.0104 0.1075 0.1258
Loa Loa (eye worm) hypothetical protein 0.0058 0.0569 0.0659
Trypanosoma cruzi hypothetical protein 0.0014 0.008 0.023
Echinococcus multilocularis RING finger protein 185 0.0014 0.008 0.0068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0021 0.001
Echinococcus multilocularis G-protein coupled receptor, putative 0.0009 0.0021 0.0009
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0021 0.0009
Entamoeba histolytica zinc finger domain containing protein 0.0014 0.008 0.0598
Brugia malayi hypothetical protein 0.0138 0.1448 0.17
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0021 0.001
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0021 0.001
Toxoplasma gondii hypothetical protein 0.0014 0.008 0.008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0021 0.001
Entamoeba histolytica zinc finger domain containing protein 0.0014 0.008 0.0598
Echinococcus multilocularis geminin 0.019 0.2031 0.2021
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0274 0.296 0.3491
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0027 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0051 0.0046
Entamoeba histolytica zinc finger domain containing protein 0.0014 0.008 0.0598
Echinococcus granulosus ring and YY1 binding protein 0.0274 0.296 0.3491
Brugia malayi RING zinc finger protein 0.0014 0.008 0.008
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0012 0.0357
Onchocerca volvulus 0.0009 0.0021 0.001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0122 0.011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0012 0.0357
Plasmodium falciparum E3 ubiquitin-protein ligase, putative 0.0014 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0014 0.008 0.008
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0274 0.296 0.3491
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0014 0.0002
Echinococcus multilocularis ring finger protein 170 0.0014 0.008 0.0068
Schistosoma mansoni opsin-like receptor 0.0009 0.0021 0.001
Loa Loa (eye worm) TYRA-2 protein 0.0009 0.0021 0.001
Toxoplasma gondii ran binding protein 0.0274 0.296 0.3491
Brugia malayi steroid hormone receptor 0.0011 0.0051 0.0046
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Schistosoma mansoni hypothetical protein 0.019 0.2031 0.239
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.0014 0.008 0.0087
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0009 0.0021 0.001
Onchocerca volvulus 0.0274 0.296 0.3491
Schistosoma mansoni inositol monophosphatase 0.0041 0.0384 0.0441
Schistosoma mansoni neuropeptide receptor 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0027 0.022 0.0246
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0009 0.0021 0.001
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0009 0.0021 0.001
Echinococcus multilocularis sex peptide receptor 0.0009 0.0021 0.0009
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Echinococcus multilocularis ring finger protein 113a 0.0014 0.008 0.0068
Onchocerca volvulus 0.0009 0.0021 0.001
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0021 0.0009
Echinococcus granulosus RING finger protein 185 0.0014 0.008 0.008
Echinococcus granulosus Smad4 0.0009 0.0027 0.0017
Brugia malayi brahma associated protein 60 kDa 0.0771 0.8457 1
Schistosoma mansoni amine GPCR 0.0009 0.0021 0.001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0014 0.0003
Leishmania major hypothetical protein, conserved 0.0014 0.008 0.023
Echinococcus granulosus allatostatin A receptor 0.0009 0.0021 0.001
Giardia lamblia Kinase 0.0014 0.008 0.5
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0771 0.8457 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0021 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0021 0.0009
Onchocerca volvulus 0.0009 0.0021 0.001
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0384 0.0441
Brugia malayi putative neuropeptide receptor NPR1 0.0009 0.0021 0.001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0051 0.0046
Brugia malayi B-box zinc finger family protein 0.0014 0.008 0.008
Schistosoma mansoni hypothetical protein 0.0046 0.0432 0.0497
Loa Loa (eye worm) hypothetical protein 0.0274 0.296 0.3491
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0545 0.0631
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0051 0.0046
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0036 0.0024
Toxoplasma gondii hypothetical protein 0.0014 0.008 0.008
Onchocerca volvulus 0.0027 0.022 0.0246
Echinococcus granulosus Zinc finger RanBP2 type 0.0274 0.296 0.3491
Schistosoma mansoni adenoreceptor 0.0009 0.0021 0.001
Trypanosoma brucei ring finger containing protein 0.0014 0.008 0.023
Echinococcus granulosus Protein patched homolog 1 0.0047 0.045 0.0519
Echinococcus granulosus g protein coupled receptor 0.0009 0.0021 0.001
Entamoeba histolytica zinc finger domain containing protein 0.0014 0.008 0.0598
Brugia malayi neuropeptide F receptor 0.0009 0.0021 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Trypanosoma brucei SNF2 family N-terminal domain/Ring finger domain containing protein, putative 0.0014 0.008 0.023
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0009 0.0021 0.001
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0014 0.008 0.008
Leishmania major hypothetical protein, conserved 0.0014 0.008 0.023
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0274 0.296 0.3491
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0134 0.3972
Schistosoma mansoni neuropeptide receptor 0.0009 0.0021 0.001
Echinococcus multilocularis neuropeptide receptor A26 0.0009 0.0021 0.0009
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0384 0.1263
Schistosoma mansoni amine GPCR 0.0009 0.0021 0.001
Leishmania major hypothetical protein, conserved 0.0014 0.008 0.023
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0105 0.011
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0021 0.001
Schistosoma mansoni hypothetical protein 0.0771 0.8457 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0771 0.8457 0.8455
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0274 0.296 0.3491
Schistosoma mansoni rnf5 0.0014 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0081 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0021 0.0009
Schistosoma mansoni coup transcription factor 0.0011 0.0051 0.0046
Loa Loa (eye worm) hypothetical protein 0.0274 0.296 0.3491
Giardia lamblia Zinc finger domain 0.0014 0.008 0.5
Loa Loa (eye worm) hypothetical protein 0.0015 0.0087 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0051 0.0046
Echinococcus granulosus hypothetical protein 0.0009 0.0021 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0021 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.1409 0.1654
Onchocerca volvulus 0.0011 0.0051 0.0046
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0122 0.013
Schistosoma mansoni intermediate filament proteins 0.003 0.0261 0.0294
Leishmania major hypothetical protein, conserved 0.0014 0.008 0.023
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0027 0.0015
Plasmodium vivax E3 ubiquitin-protein ligase, putative 0.0014 0.008 0.008
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0021 0.0009
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0021 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0771 0.8457 1
Schistosoma mansoni biogenic amine receptor 0.0009 0.0021 0.001
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0051 0.0046
Leishmania major hypothetical protein, unknown function 0.0014 0.008 0.023
Schistosoma mansoni mind bomb 0.0014 0.008 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.008 0.023
Brugia malayi hypothetical protein 0.0014 0.008 0.008
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0122 0.013
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.008 0.023
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0009 0.0021 0.001
Echinococcus granulosus g protein coupled receptor 0.0009 0.0021 0.001
Schistosoma mansoni opsin-like receptor 0.0009 0.0021 0.001
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0051 0.0046
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.022 0.5587
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0146 0.0158
Plasmodium vivax DNA repair protein RAD5, putative 0.0014 0.008 0.008
Echinococcus multilocularis smad 0.0009 0.0027 0.0015
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0021 0.0009
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0051 0.0046
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Brugia malayi MH2 domain containing protein 0.0009 0.0027 0.0017
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0014 0.008 0.0087
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.1409 0.1654
Echinococcus granulosus g-protein coupled receptor 0.0009 0.0021 0.001
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0021 0.001
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0009 0.0021 0.001
Brugia malayi hypothetical protein 0.0009 0.0021 0.001
Plasmodium vivax trophozoite exported protein 1, putative 0.0014 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0014 0.008 0.008
Schistosoma mansoni hypothetical protein 0.0771 0.8457 1
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0021 0.0009
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0146 0.0158
Schistosoma mansoni hypothetical protein 0.019 0.2031 0.239
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0014 0.0002
Trypanosoma brucei DNA repair protein, putative 0.0014 0.008 0.023
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0602 0.0698
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.022 0.5587
Brugia malayi hypothetical protein 0.0009 0.0021 0.001
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0014 0.008 0.008
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0012 0.0357
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0021 0.001
Schistosoma mansoni amine GPCR 0.0009 0.0021 0.001
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0051 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0051 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0384 0.3276
Loa Loa (eye worm) hypothetical protein 0.0014 0.008 0.008
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.022 0.0706
Schistosoma mansoni RNA binding protein 0.0274 0.296 0.3491
Entamoeba histolytica zinc finger domain containing protein 0.0014 0.008 0.0598
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0122 0.013
Onchocerca volvulus 0.0009 0.0021 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0265 0.2863 0.3376
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0021 0.001
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0051 0.0046
Brugia malayi hypothetical protein 0.0009 0.0021 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0021 0.001
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.022 0.0706
Brugia malayi G-protein coupled receptor 0.0009 0.0021 0.001
Schistosoma mansoni cpg binding protein 0.0032 0.0282 0.032
Echinococcus granulosus somatostatin receptor 0.0009 0.0021 0.001
Brugia malayi Zinc finger, C2H2 type family protein 0.0014 0.008 0.008
Brugia malayi hypothetical protein 0.0265 0.2863 0.3376
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.022 0.5587
Schistosoma mansoni Smad4 0.0009 0.0027 0.0017
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Brugia malayi brahma associated protein 60 kDa 0.0771 0.8457 1
Echinococcus granulosus dro:myosuppressin receptor 0.0009 0.0021 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0012 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0021 0.001
Brugia malayi intermediate filament protein 0.003 0.0261 0.0294
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0009 0.0021 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Plasmodium vivax E3 ubiquitin-protein ligase RNF5, putative 0.0014 0.008 0.008
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0051 0.0046
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Schistosoma mansoni hypothetical protein 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0027 0.022 0.0246
Entamoeba histolytica hypothetical protein 0.0014 0.008 0.0598
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0012 0.0357
Brugia malayi Dopamine receptor protein 2 0.0009 0.0021 0.001
Echinococcus granulosus G protein coupled receptor 139 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Chlamydia trachomatis SWIB complex protein 0.0771 0.8457 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.008 0.008
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.022 0.5587
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0111 0.1149 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0021 0.001
Leishmania major hypothetical protein, conserved 0.0014 0.008 0.023
Brugia malayi AMP-binding enzyme family protein 0.0027 0.022 0.0246
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.022 0.183
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0027 0.0017
Brugia malayi hypothetical protein 0.0014 0.008 0.008
Onchocerca volvulus 0.0009 0.0021 0.001
Toxoplasma gondii hypothetical protein 0.0014 0.008 0.008
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0051 0.0046
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Trypanosoma cruzi hypothetical protein 0.0014 0.008 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Brugia malayi AMP-binding enzyme family protein 0.0027 0.022 0.0246
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Schistosoma mansoni biogenic amine receptor 0.0009 0.0021 0.001
Brugia malayi AMP-binding enzyme family protein 0.0027 0.022 0.0246
Trichomonas vaginalis ion channel nompc, putative 0.0014 0.008 0.0087
Leishmania major hypothetical protein, conserved 0.0014 0.008 0.023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.0046
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0009 0.0021 0.0009
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0274 0.296 0.3491
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0021 0.0009
Brugia malayi MH2 domain containing protein 0.0009 0.0027 0.0017
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0384 0.0373
Brugia malayi hypothetical protein 0.0009 0.0021 0.001
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0014 0.008 0.0087
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.022 0.5587
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0274 0.296 0.3491
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0035 0.0027
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0051 0.0046
Plasmodium falciparum RING zinc finger protein, putative 0.0014 0.008 0.008
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0009 0.0021 0.0009
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0545 0.0631
Loa Loa (eye worm) intermediate filament protein 0.003 0.0261 0.0294
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0012 0.0357
Plasmodium vivax hypothetical protein, conserved 0.0771 0.8457 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Loa Loa (eye worm) hypothetical protein 0.003 0.0261 0.0294
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0261 0.0294
Trypanosoma cruzi WLM domain containing protein, putative 0.0274 0.296 1
Brugia malayi G-protein coupled receptor 0.0009 0.0021 0.001
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0021 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0021 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0021 0.001
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0134 0.3972
Schistosoma mansoni neuropeptide f receptor 76f 0.0009 0.0021 0.001
Echinococcus granulosus sex peptide receptor 0.0009 0.0021 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0051 0.0046
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Schistosoma mansoni smad 0.0009 0.0027 0.0017
Loa Loa (eye worm) hypothetical protein 0.0274 0.296 0.3491
Echinococcus granulosus Niemann Pick C1 protein 0.0111 0.1149 0.1346
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Brugia malayi MH2 domain containing protein 0.0134 0.1409 0.1654
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0051 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0021 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.008 0.023
Brugia malayi Dopamine receptor 0.0009 0.0021 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0134 0.3972
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Loa Loa (eye worm) RING finger protein 20 0.0014 0.008 0.008
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Echinococcus granulosus neuropeptide receptor 0.0009 0.0021 0.001
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0009 0.0021 0.001
Echinococcus granulosus tm gpcr rhodopsin 0.0634 0.6937 0.82
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0051 0.0046
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0261 0.0294
Onchocerca volvulus 0.0014 0.008 0.008
Onchocerca volvulus 0.0009 0.0021 0.001
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Brugia malayi RE15519p 0.0009 0.0021 0.001
Schistosoma mansoni opsin-like receptor 0.0009 0.0021 0.001
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0014 0.008 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0105 0.011
Brugia malayi Melatonin receptor type 1A 0.0009 0.0021 0.001
Trypanosoma brucei Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Schistosoma mansoni smad1 5 8 and 0.0009 0.0027 0.0017
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0021 0.001
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0021 0.0009
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0274 0.296 0.3491
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0158
Echinococcus granulosus lamin dm0 0.003 0.0261 0.0294
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0051 0.0046
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0051 0.0046
Onchocerca volvulus Huntingtin homolog 0.0138 0.1448 0.17
Leishmania major hypothetical protein, conserved 0.0274 0.296 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0009 0.0021 0.001
Schistosoma mansoni lamin 0.003 0.0261 0.0294
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0274 0.296 0.2952
Echinococcus multilocularis lamin 0.003 0.0261 0.0249
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Echinococcus granulosus ring finger protein 113a 0.0014 0.008 0.008
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0051 0.0046
Leishmania major DNA repair protein-like protein 0.0014 0.008 0.023
Echinococcus granulosus zinc finger protein Ran binding 0.0274 0.296 0.3491
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0051 0.0046
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0021 0.001
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0384 0.0447
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0051 0.0039
Brugia malayi putative neuropeptide receptor 0.0009 0.0021 0.001
Echinococcus multilocularis SWI:SNF matrix associated 0.0771 0.8457 0.8455
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0021 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Brugia malayi Serotonin receptor 0.0009 0.0021 0.001
Onchocerca volvulus 0.0009 0.0021 0.001
Echinococcus multilocularis somatostatin receptor 0.0009 0.0021 0.0009
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0051 0.0039
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0012 0.0357
Schistosoma mansoni peter pan-related 0.0014 0.008 0.008
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0274 0.296 0.2952
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0021 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.008 0.008
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0349 0.0399
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0014 0.008 0.0068
Onchocerca volvulus 0.003 0.0261 0.0294
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0051 0.0039
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0087 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0021 0.001
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0014 0.008 0.0087
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Schistosoma mansoni zinc finger protein 0.0014 0.008 0.008
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0021 0.0009
Loa Loa (eye worm) histone methyltransferase 0.001 0.0036 0.0028
Plasmodium falciparum E3 ubiquitin-protein ligase RNF5, putative 0.0014 0.008 0.008
Brugia malayi hypothetical protein 0.0014 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0122 0.013
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0254 0.0287
Loa Loa (eye worm) hypothetical protein 0.0274 0.296 0.3491
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0021 0.001
Brugia malayi Niemann-Pick C1 protein precursor 0.0111 0.1149 0.1346
Schistosoma mansoni amine GPCR 0.0009 0.0021 0.001
Entamoeba histolytica zinc finger domain containing protein 0.0014 0.008 0.0598
Onchocerca volvulus 0.0009 0.0021 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0051 0.0046
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0384 0.1263
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0384 0.1263
Giardia lamblia Hypothetical protein 0.0014 0.008 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.0009 0.0021 0.001
Onchocerca volvulus 0.0014 0.008 0.008
Leishmania major hypothetical protein, conserved 0.0274 0.296 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0021 0.001
Leishmania major hypothetical protein, conserved 0.0274 0.296 1
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0014 0.008 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0014 0.008 0.023
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0014 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.0046
Giardia lamblia Hypothetical protein 0.0014 0.008 0.5
Schistosoma mansoni inositol monophosphatase 0.0041 0.0384 0.0441
Brugia malayi G protein-coupled receptor 0.0009 0.0021 0.001
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0009 0.0021 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0274 0.296 1
Echinococcus multilocularis serotonin receptor 0.0009 0.0021 0.0009
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0014 0.008 0.0068
Onchocerca volvulus 0.0009 0.0021 0.001
Leishmania major hypothetical protein, conserved 0.0014 0.008 0.023
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0051 0.0039
Echinococcus granulosus orexin receptor type 2 0.0009 0.0021 0.001
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0014 0.008 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0014 0.0003
Schistosoma mansoni hypothetical protein 0.0014 0.008 0.008
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0021 0.001
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0027 0.0017
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Onchocerca volvulus Huntingtin homolog 0.0138 0.1448 0.17
Onchocerca volvulus 0.0054 0.0525 0.0607
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0146 0.433
Leishmania major hypothetical protein, conserved 0.0274 0.296 1
Echinococcus multilocularis protein patched 0.0047 0.045 0.0439
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0274 0.296 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0051 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0051 0.0046
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.022 0.6544
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.022 0.5587
Trypanosoma brucei hypothetical protein, conserved 0.0274 0.296 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0009 0.0021 0.001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0051 0.0046
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0051 0.0046
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Brugia malayi Dopamine receptor protein 1 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0138 0.1448 0.17
Loa Loa (eye worm) Smad1 0.0009 0.0027 0.0017
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Loa Loa (eye worm) inositol-1 0.0041 0.0384 0.0441
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0014 0.008 0.0087
Schistosoma mansoni ring finger protein 151 0.0014 0.008 0.008
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.045 0.0519
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0384 0.5
Echinococcus multilocularis ring and YY1 binding protein 0.0274 0.296 0.2952
Echinococcus granulosus fmrfamide receptor 0.0009 0.0021 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0014 0.008 0.0068
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0009 0.0021 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.008 0.023
Echinococcus granulosus neuropeptide FF receptor 2 0.0009 0.0021 0.001
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Onchocerca volvulus 0.0014 0.008 0.008
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.0021 0.001
Echinococcus multilocularis Niemann Pick C1 protein 0.0111 0.1149 0.1138
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0009 0.0021 0.001
Echinococcus granulosus geminin 0.019 0.2031 0.239
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0014 0.008 0.008
Onchocerca volvulus 0.0009 0.0021 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0021 0.0009
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0014 0.008 0.0068
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0014 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Brugia malayi Smad1 0.0009 0.0027 0.0017
Loa Loa (eye worm) hypothetical protein 0.0111 0.1149 0.1346
Schistosoma mansoni hypothetical protein 0.0009 0.0021 0.001
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0009 0.0021 0.001
Brugia malayi ecdysteroid receptor 0.0011 0.0051 0.0046
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0274 0.296 0.3491
Giardia lamblia Ribonuclease 0.0014 0.008 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0021 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Toxoplasma gondii helicase, putative 0.0014 0.008 0.008
Plasmodium falciparum trophozoite exported protein 1 0.0014 0.008 0.008
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0009 0.0021 0.001
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Schistosoma mansoni hypothetical protein 0.0046 0.0432 0.0497
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Schistosoma mansoni cpg binding protein 0.0034 0.0303 0.0344
Leishmania major hypothetical protein 0.0014 0.008 0.023
Trichomonas vaginalis ankyrin, putative 0.0014 0.008 0.0087
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Brugia malayi Tachykinin-like peptides receptor 99D 0.0009 0.0021 0.001
Giardia lamblia Hypothetical protein 0.0014 0.008 0.5
Leishmania major hypothetical protein, conserved 0.0014 0.008 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Onchocerca volvulus 0.0009 0.0021 0.001
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.0009 0.0021 0.0009
Echinococcus granulosus GPCR family 2 0.0018 0.0122 0.013
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0771 0.8457 1
Onchocerca volvulus RING finger protein 141 homolog 0.0014 0.008 0.008
Loa Loa (eye worm) melatonin receptor type 1A 0.0009 0.0021 0.001
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0051 0.0046
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0051 0.0046
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0027 0.0017
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger) containing protein, putative 0.0014 0.008 0.023
Onchocerca volvulus 0.0014 0.008 0.008
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0014 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0014 0.008 0.008
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0021 0.0009
Onchocerca volvulus 0.0014 0.008 0.008
Plasmodium falciparum zinc finger protein, putative 0.0014 0.008 0.008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0051 0.0046
Schistosoma mansoni hypothetical protein 0.0274 0.296 0.3491
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Onchocerca volvulus 0.0009 0.0021 0.001
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0274 0.296 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0009 0.0021 0.0009
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0014 0.008 0.008
Trypanosoma brucei hypothetical protein, conserved 0.0274 0.296 1
Schistosoma mansoni hypothetical protein 0.0014 0.008 0.008
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0122 0.013
Onchocerca volvulus 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.0046
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0274 0.296 1
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0021 0.0009
Echinococcus multilocularis neuropeptide FF receptor 2 0.0009 0.0021 0.0009
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0634 0.6937 0.6933
Giardia lamblia Hypothetical protein 0.0014 0.008 0.5
Brugia malayi Neuralized family protein 0.0014 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Giardia lamblia E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B 0.0014 0.008 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.008 0.023
Onchocerca volvulus 0.0771 0.8457 1
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0051 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Onchocerca volvulus Protein neuralized homolog 0.0014 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0014 0.008 0.008
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0021 0.0009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Brugia malayi follicle stimulating hormone receptor 0.0009 0.0021 0.001
Echinococcus granulosus alpha 1A adrenergic receptor 0.0009 0.0021 0.001
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0009 0.0021 0.0009
Brugia malayi hypothetical protein 0.0009 0.0021 0.001
Schistosoma mansoni lamin 0.003 0.0261 0.0294
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0384 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0384 0.0447
Echinococcus granulosus 7TM GPCR rhodopsin 0.0009 0.0021 0.001
Echinococcus multilocularis cpg binding protein 0.0034 0.0303 0.0291
Brugia malayi nuclear hormone receptor 0.0011 0.0051 0.0046
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0014 0.0003
Brugia malayi Zinc finger protein 183 homolog 0.0014 0.008 0.008
Schistosoma mansoni zinc finger protein 0.0274 0.296 0.3491
Echinococcus multilocularis survival motor neuron protein 1 0.0265 0.2863 0.2855
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0009 0.0021 0.001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0051 0.0046
Leishmania major hypothetical protein, conserved 0.0014 0.008 0.023
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0021 0.001
Onchocerca volvulus 0.0274 0.296 0.3491
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0051 0.0046
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0158
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0021 0.0009
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0274 0.296 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0051 0.0039
Schistosoma mansoni hypothetical protein 0.0018 0.0122 0.013
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0112 0.1168 0.1368
Brugia malayi hypothetical protein 0.0009 0.0021 0.001
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0021 0.0009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0134 0.3972
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Echinococcus granulosus ring finger protein 170 0.0014 0.008 0.008
Leishmania major hypothetical protein, conserved 0.0014 0.008 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Brugia malayi hypothetical protein 0.0014 0.008 0.008
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Brugia malayi hypothetical protein 0.0014 0.008 0.008
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0027 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0051 0.0046
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.022 0.183
Onchocerca volvulus 0.0009 0.0021 0.001
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0027 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0051 0.0046
Entamoeba histolytica hypothetical protein 0.0014 0.008 0.0598
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0336 1
Trichomonas vaginalis ankyrin, putative 0.0014 0.008 0.0087
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0771 0.8457 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0158 0.1674 0.1664
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0051 0.0046
Echinococcus granulosus Niemann Pick C1 protein 0.0158 0.1674 0.1968
Entamoeba histolytica zinc finger domain containing protein 0.0014 0.008 0.0598
Onchocerca volvulus 0.0014 0.008 0.008
Echinococcus granulosus cpg binding protein 0.0034 0.0303 0.0344
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.045 0.0439
Brugia malayi hypothetical protein 0.0009 0.0021 0.001
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.022 0.6544
Echinococcus multilocularis g-protein coupled receptor 0.0009 0.0021 0.0009
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0012 0.0357
Brugia malayi ORL1-like opioid receptor 0.0009 0.0021 0.001
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Brugia malayi SWIB/MDM2 domain containing protein 0.0771 0.8457 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0051 0.0046
Loa Loa (eye worm) RiNg Finger protein family member 0.0014 0.008 0.008
Echinococcus multilocularis SWI:SNF matrix associated 0.0771 0.8457 0.8455
Giardia lamblia Ser/Thr protein kinase 0.0014 0.008 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0384 0.0441
Schistosoma mansoni cpg binding protein 0.0034 0.0303 0.0344
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0014 0.008 0.0087
Schistosoma mansoni hypothetical protein 0.0054 0.0525 0.0607
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0282 0.032
Trypanosoma cruzi hypothetical protein, conserved 0.0274 0.296 1
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0336 1
Brugia malayi RING finger protein 20 0.0014 0.008 0.008
Schistosoma mansoni smad1 5 8 and 0.0009 0.0027 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0021 0.001
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0051 0.0046
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.022 0.0706
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Loa Loa (eye worm) hypothetical protein 0.0027 0.022 0.0246
Schistosoma mansoni hypothetical protein 0.0018 0.0122 0.013
Onchocerca volvulus 0.0009 0.0021 0.001
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0012 0.0357
Loa Loa (eye worm) hypothetical protein 0.0014 0.008 0.008
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0021 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0021 0.0009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Echinococcus multilocularis zinc finger protein Ran binding 0.0274 0.296 0.2952
Echinococcus granulosus survival motor neuron protein 1 0.0265 0.2863 0.3376
Onchocerca volvulus 0.003 0.0261 0.0294
Schistosoma mansoni hypothetical protein 0.0018 0.0122 0.013
Schistosoma mansoni brg-1 associated factor 0.0771 0.8457 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0012 0.0357
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0051 0.0046
Brugia malayi nuclear receptor NHR-88 0.0011 0.0051 0.0046
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0014 0.008 0.008
Echinococcus multilocularis musashi 0.003 0.0261 0.0249
Toxoplasma gondii SWI2/SNF2-containing protein RAD5 0.0014 0.008 0.008
Brugia malayi Serotonin receptor 0.0009 0.0021 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0051 0.0046
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0771 0.8457 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Echinococcus granulosus SWI:SNF matrix associated 0.0771 0.8457 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Schistosoma mansoni hypothetical protein 0.0018 0.0122 0.013
Echinococcus granulosus neuropeptide s receptor 0.0009 0.0021 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.022 0.5587
Plasmodium vivax RING zinc finger protein, putative 0.0014 0.008 0.008
Schistosoma mansoni smad1 5 8 and 0.0009 0.0027 0.0017
Brugia malayi neuropeptide F receptor 0.0009 0.0021 0.001
Brugia malayi hypothetical protein 0.0009 0.0021 0.001
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Schistosoma mansoni hypothetical protein 0.0009 0.0021 0.001
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0021 0.001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0122 0.013
Leishmania major hypothetical protein, conserved 0.0014 0.008 0.023
Schistosoma mansoni biogenic amine receptor 0.0009 0.0021 0.001
Leishmania major hypothetical protein, conserved 0.0274 0.296 1
Echinococcus granulosus intermediate filament protein 0.003 0.0261 0.0294
Schistosoma mansoni hypothetical protein 0.0046 0.0432 0.0497
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0158
Echinococcus multilocularis orexin receptor type 2 0.0009 0.0021 0.0009
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0014 0.008 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.008 0.023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0682 0.0794
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.022 0.6416
Brugia malayi hypothetical protein 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Echinococcus multilocularis allatostatin A receptor 0.0009 0.0021 0.0009
Echinococcus granulosus tachykinin peptides receptor 99D 0.0009 0.0021 0.001
Toxoplasma gondii RING zinc finger protein 0.0014 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0349 0.0399
Giardia lamblia Protein 21.1 0.0014 0.008 0.5
Giardia lamblia Zinc finger domain 0.0014 0.008 0.5
Echinococcus multilocularis lamin dm0 0.003 0.0261 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Echinococcus multilocularis serotonin receptor 0.0009 0.0021 0.0009
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0012 0.0007
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0014 0.008 0.0068
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Leishmania major hypothetical protein, conserved 0.0014 0.008 0.023
Brugia malayi YY1-associated factor 2 0.0274 0.296 0.3491
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.0021 0.001
Echinococcus granulosus peptide allatostatin:somatostatin 0.0009 0.0021 0.001
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Schistosoma mansoni TRABID protein (C64 family) 0.0274 0.296 0.3491
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0021 0.0009
Schistosoma mansoni survival motor neuron protein 0.0054 0.0525 0.0607
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0009 0.0021 0.001
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Entamoeba histolytica SPRY domain protein 0.0014 0.008 0.0598
Brugia malayi GnHR receptor homolog 0.0009 0.0021 0.001
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.022 0.6416
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0014 0.008 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.045 0.0525
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0009 0.0021 0.0009
Trypanosoma cruzi WLM domain containing protein, putative 0.0274 0.296 1
Schistosoma mansoni neuropeptide receptor 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0014 0.008 0.008
Toxoplasma gondii hypothetical protein 0.0014 0.008 0.008
Echinococcus multilocularis expressed conserved protein 0.0104 0.1075 0.1064
Loa Loa (eye worm) hypothetical protein 0.0014 0.0081 0.0082
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0051 0.0039
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0051 0.0046
Schistosoma mansoni hypothetical protein 0.0009 0.0021 0.001
Schistosoma mansoni hypothetical protein 0.0014 0.008 0.008
Brugia malayi hypothetical protein 0.0014 0.008 0.008
Onchocerca volvulus 0.0274 0.296 0.3491
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.0046
Schistosoma mansoni growth hormone secretagogue receptor 0.0009 0.0021 0.001
Echinococcus multilocularis G protein coupled receptor 139 0.0009 0.0021 0.0009
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0051 0.0039
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0009 0.0021 0.001
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0051 0.0046
Mycobacterium ulcerans hypothetical protein 0.0027 0.022 0.5587
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0771 0.8457 0.8455
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Giardia lamblia Hypothetical protein 0.0014 0.008 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Echinococcus multilocularis GPCR, family 2 0.0018 0.0122 0.011
Trichomonas vaginalis ankyrin, putative 0.0014 0.008 0.0087
Echinococcus granulosus serotonin receptor 0.0009 0.0021 0.001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0051 0.0046
Brugia malayi CHE-14 protein 0.0047 0.045 0.0519
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.008 0.023
Chlamydia trachomatis DNA topoisomerase I 0.0771 0.8457 1
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0274 0.296 0.3491
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0021 0.001
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Schistosoma mansoni amine GPCR 0.0009 0.0021 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0051 0.0046
Plasmodium vivax zinc finger protein, putative 0.0014 0.008 0.008
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0051 0.0046
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0051 0.0046
Loa Loa (eye worm) hypothetical protein 0.0056 0.0545 0.0631
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0012 0.0357
Trypanosoma cruzi hypothetical protein, conserved 0.0274 0.296 1
Echinococcus granulosus g protein coupled receptor 0.0009 0.0021 0.001
Onchocerca volvulus 0.0009 0.0021 0.001
Trypanosoma brucei predicted zinc finger protein 0.0014 0.008 0.023
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0009 0.0021 0.0009
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0014 0.008 0.023
Echinococcus granulosus smad 0.0009 0.0027 0.0017
Onchocerca volvulus 0.0274 0.296 0.3491
Echinococcus granulosus lamin 0.003 0.0261 0.0294
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0021 0.0009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0274 0.296 1
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0274 0.296 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0087 0.0075
Schistosoma mansoni myosin xvIII 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0021 0.001
Brugia malayi larval opioid receptor 0.0009 0.0021 0.001
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0771 0.8457 1
Echinococcus granulosus neuropeptide receptor 0.0009 0.0021 0.001
Toxoplasma gondii Bardet-Biedl syndrome 5, putative 0.0014 0.008 0.008
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0021 0.001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0036 0.0028
Giardia lamblia Kinase, NEK 0.0014 0.008 0.5
Loa Loa (eye worm) brahma associated protein 0.0771 0.8457 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0009 0.0021 0.001
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0009 0.0021 0.001
Schistosoma mansoni hypothetical protein 0.0046 0.0432 0.0497
Loa Loa (eye worm) hypothetical protein 0.0014 0.008 0.008
Brugia malayi hypothetical protein 0.0009 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0047 0.045 0.0519
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0021 0.001
Brugia malayi MH1 domain containing protein 0.0009 0.0027 0.0017
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.008 0.023
Schistosoma mansoni patched 1 0.0047 0.045 0.0519
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0014 0.008 0.008
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.045 0.0519
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0146 0.3588
Schistosoma mansoni hypothetical protein 0.0771 0.8457 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0545 0.0631
Loa Loa (eye worm) hypothetical protein 0.0138 0.1448 0.17
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0051 0.0046
Brugia malayi sulfakinin receptor protein 0.0009 0.0021 0.001
Onchocerca volvulus 0.0009 0.0021 0.001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.022 0.183
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.0046
Giardia lamblia Hypothetical protein 0.0014 0.008 0.5
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0525 0.0607
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.008 0.0087
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0051 0.0046

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 547 nM Binding affinity of the compound towards Opioid receptor mu 1 was determined using ([d-Ala2,MePhe4, Gly5-ol]-enkephalin (DAMGO) as the radioligand. ChEMBL. 12372527
Ki (binding) = 547 nM Binding affinity of the compound towards Opioid receptor mu 1 was determined using ([d-Ala2,MePhe4, Gly5-ol]-enkephalin (DAMGO) as the radioligand. ChEMBL. 12372527
Ki (binding) > 10000 nM Binding affinity of the compound towards Opioid receptor kappa 1 was determined using U69,593 as the radioligand. ChEMBL. 12372527
Ki (binding) > 10000 nM Binding affinity of the compound towards Opioid receptor delta 1 was determined using [d-Ser2, Leu5, Thr6] enkephalin (DSLET) as the radioligand. ChEMBL. 12372527
Ki (binding) > 10000 nM Binding affinity of the compound towards Opioid receptor kappa 1 was determined using U69,593 as the radioligand. ChEMBL. 12372527
Ki (binding) > 10000 nM Binding affinity of the compound towards Opioid receptor delta 1 was determined using [d-Ser2, Leu5, Thr6] enkephalin (DSLET) as the radioligand. ChEMBL. 12372527

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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