Detailed information for compound 1771041

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 445.55 | Formula: C28H31NO4
  • H donors: 0 H acceptors: 1 LogP: 6.56 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c1c(C)ccc(c1n2CCCCCOc1ccccc1C(=O)OC)C
  • InChi: 1S/C28H31NO4/c1-19-12-13-20(2)27-26(19)23-18-21(31-3)14-15-24(23)29(27)16-8-5-9-17-33-25-11-7-6-10-22(25)28(30)32-4/h6-7,10-15,18H,5,8-9,16-17H2,1-4H3
  • InChiKey: JSAMVPZPEFBLQJ-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii AtPH1 family protein 0.0056 0.0163 0.4424
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Echinococcus granulosus beta 1 syntrophin 0.0056 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0023
Brugia malayi MAX-1A 0.0056 0.0163 0.0233
Schistosoma mansoni importin beta-1 0.0024 0.0043 0.0043
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0056 0.0163 0.1011
Schistosoma mansoni vav2 0.0056 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0006
Brugia malayi beta-lactamase family protein 0.003 0.0066 0.0095
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0066 0.0343
Echinococcus multilocularis expressed protein 0.042 0.1533 0.1533
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0056 0.0163 0.0163
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0066 0.0201 1
Echinococcus granulosus Rho GTPase activating protein 24 0.0056 0.0163 0.0163
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0056 0.0163 0.8022
Onchocerca volvulus 0.0056 0.0163 0.0841
Echinococcus granulosus cytohesin 1 0.0056 0.0163 0.0163
Trichomonas vaginalis centaurin/arf, putative 0.0056 0.0163 0.0921
Echinococcus multilocularis Rho GTPase activating protein 24 0.0056 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0056 0.0163 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Echinococcus multilocularis axis inhibition protein axin 0.042 0.1533 0.1533
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Trichomonas vaginalis centaurin/arf, putative 0.0056 0.0163 0.0921
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.003 0.0066 0.0066
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0087 0.0282 0.0282
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0023 0.0033
Entamoeba histolytica protein kinase, putative 0.0066 0.0201 0.126
Loa Loa (eye worm) hypothetical protein 0.0048 0.0134 0.0134
Echinococcus multilocularis pleckstrin y domain containing family A 0.0056 0.0163 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Trypanosoma cruzi PAB1-binding protein , putative 0.0048 0.0134 0.6505
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0056 0.0163 0.0163
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0039 0.0099 0.0142
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0066 0.0201 0.5515
Toxoplasma gondii HEAT repeat-containing protein 0.0024 0.0043 0.0984
Trypanosoma cruzi hypothetical protein 0.0056 0.0163 0.8022
Echinococcus granulosus DCC interacting protein 13 beta 0.0056 0.0163 0.0163
Mycobacterium ulcerans beta-lactamase 0.003 0.0066 0.172
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Plasmodium falciparum calcium-dependent protein kinase 7 0.0066 0.0201 1
Entamoeba histolytica hypothetical protein 0.0056 0.0163 0.1011
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Trypanosoma brucei protein kinase, putative 0.0066 0.0201 1
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0019 0.0026 0.0104
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Schistosoma mansoni goodpasture antigen-binding protein 0.0056 0.0163 0.0163
Brugia malayi Variant SH3 domain containing protein 0.0056 0.0163 0.0233
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0015 0.0009 0.0084
Schistosoma mansoni growth factor receptor-bound protein 0.0056 0.0163 0.0163
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0023 0.0305
Entamoeba histolytica hypothetical protein 0.0056 0.0163 0.1011
Echinococcus multilocularis Regulator of G protein signaling 20 0.042 0.1533 0.1533
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0017 0.002 0.056
Brugia malayi Oxysterol binding protein 0.0056 0.0163 0.0233
Trypanosoma brucei PH domain containing protein, putative 0.0056 0.0163 0.8023
Echinococcus granulosus importin subunit beta 1 0.0024 0.0043 0.0043
Entamoeba histolytica protein kinase, putative 0.0066 0.0201 0.126
Loa Loa (eye worm) hypothetical protein 0.042 0.1533 0.1533
Echinococcus multilocularis oxysterol binding protein 3 0.0056 0.0163 0.0163
Plasmodium vivax PH domain containing protein 0.0056 0.0163 0.8053
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0056 0.0163 0.1011
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0201 0.126
Trichomonas vaginalis centaurin beta, putative 0.0056 0.0163 0.0921
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1452 0.542 0.7744
Echinococcus multilocularis snurportin 1 0.0253 0.0905 0.0905
Entamoeba histolytica ARF GTPase activating protein, putative 0.0056 0.0163 0.1011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0087 0.0282 0.0282
Entamoeba histolytica hypothetical protein 0.042 0.1533 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0017 0.002 0.0309
Trichomonas vaginalis centaurin gamma, putative 0.0056 0.0163 0.0921
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0017 0.002 1
Schistosoma mansoni axis inhibition protein axin 0.042 0.1533 0.1533
Echinococcus multilocularis geminin 0.014 0.0482 0.0482
Echinococcus multilocularis regulator of G protein signaling 7 0.042 0.1533 0.1533
Brugia malayi probable spectrin beta chain 0.0056 0.0163 0.0233
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0107 0.0357 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.267 1 1
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0056 0.0163 0.1011
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0056 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0066 0.0201 1
Entamoeba histolytica hypothetical protein 0.0066 0.0201 0.126
Entamoeba histolytica hypothetical protein 0.0056 0.0163 0.1011
Entamoeba histolytica acyl-coA synthetase, putative 0.0018 0.0023 0.0096
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0056 0.0163 0.1011
Schistosoma mansoni oxysterol-binding protein 1 0.0056 0.0163 0.0163
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Schistosoma mansoni goodpasture antigen-binding protein 0.0056 0.0163 0.0163
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0087 0.0282 0.0282
Onchocerca volvulus 0.003 0.0066 0.0258
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0056 0.0163 0.1011
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0066 0.2992
Echinococcus multilocularis oxysterol binding protein 9 0.0056 0.0163 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0077 0.0244 0.0349
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0066 0.2992
Trichomonas vaginalis conserved hypothetical protein 0.042 0.1533 0.9111
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0021 0.0035 0.0035
Onchocerca volvulus 0.003 0.0066 0.0258
Schistosoma mansoni syntrophin 0.0056 0.0163 0.0163
Schistosoma mansoni hypothetical protein 0.014 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Mycobacterium ulcerans esterase/lipase LipP 0.003 0.0066 0.172
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0066 0.0201 1
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0056 0.0163 0.0921
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0056 0.0163 0.0163
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0066 0.0343
Echinococcus granulosus dynamin 1 0.0056 0.0163 0.0163
Trichomonas vaginalis esterase, putative 0.003 0.0066 0.0343
Plasmodium vivax hypothetical protein, conserved 0.0056 0.0163 0.8053
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0056 0.0163 0.1011
Brugia malayi MH2 domain containing protein 0.0113 0.0377 0.0539
Trypanosoma cruzi hypothetical protein 0.0056 0.0163 0.8022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0023
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0056 0.0163 0.0163
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0009 0.0009
Brugia malayi PH domain containing protein 0.0056 0.0163 0.0233
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0056 0.0163 0.8053
Entamoeba histolytica Ran family GTPase 0.0017 0.002 0.0071
Loa Loa (eye worm) syntrophin-1 0.0056 0.0163 0.0163
Schistosoma mansoni dynamin 0.0056 0.0163 0.0163
Leishmania major GTP-binding protein, putative 0.0017 0.002 0.0309
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0015 0.0009 0.5
Brugia malayi Cytohesin 3 0.0056 0.0163 0.0233
Mycobacterium tuberculosis Probable esterase LipL 0.003 0.0066 0.0946
Trichomonas vaginalis penicillin-binding protein, putative 0.003 0.0066 0.0343
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0056 0.0163 0.0163
Loa Loa (eye worm) AGC/AKT protein kinase 0.0066 0.0201 0.0201
Schistosoma mansoni hypothetical protein 0.0056 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Schistosoma mansoni ap endonuclease 0.0015 0.0009 0.0009
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0056 0.0163 0.1011
Loa Loa (eye worm) hypothetical protein 0.003 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.0021 0.0035 0.0035
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0006
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0023 0.05
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0066 0.0201 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0015 0.0009 0.5
Trypanosoma cruzi NIMA-related kinase, putative 0.0066 0.0201 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0018 0.0023 0.0096
Echinococcus multilocularis muscleblind protein 0.0593 0.2186 0.2186
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Brugia malayi Syntrophin-1 0.0056 0.0163 0.0233
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0066 0.0201 1
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0066 0.0201 0.1148
Toxoplasma gondii hypothetical protein 0.0056 0.0163 0.4424
Onchocerca volvulus 0.0056 0.0163 0.0841
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0066 0.0201 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0021 0.0035 0.0035
Echinococcus granulosus oxysterol binding protein 3 0.0056 0.0163 0.0163
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1872 0.6998 0.6998
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0009 0.0009
Toxoplasma gondii hypothetical protein 0.0056 0.0163 0.4424
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0056 0.0163 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0201 0.126
Schistosoma mansoni serine/threonine protein kinase 0.1872 0.6998 0.6998
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0056 0.0163 0.0841
Toxoplasma gondii phosphatidylinositol transfer protein 0.0056 0.0163 0.4424
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0087 0.0282 0.0282
Echinococcus multilocularis Ras associated and pleckstrin y 0.0056 0.0163 0.0163
Plasmodium falciparum PH domain-containing protein, putative 0.0056 0.0163 0.8053
Echinococcus granulosus axis inhibition protein axin 0.042 0.1533 0.1533
Entamoeba histolytica p21-activated kinase 0.0066 0.0201 0.126
Echinococcus multilocularis myotubularin protein 13 0.0056 0.0163 0.0163
Brugia malayi PH domain containing protein 0.0056 0.0163 0.0233
Loa Loa (eye worm) hypothetical protein 0.042 0.1533 0.1533
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Schistosoma mansoni dynamin 0.0056 0.0163 0.0163
Echinococcus granulosus G protein coupled receptor kinase 1 0.225 0.8421 0.8421
Echinococcus granulosus myotubularin protein 13 0.0056 0.0163 0.0163
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0023 0.05
Echinococcus multilocularis regulator of G protein signaling 3 0.042 0.1533 0.1533
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Entamoeba histolytica PH domain containing protein 0.0056 0.0163 0.1011
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0023 0.0033
Toxoplasma gondii Oxysterol-binding protein 0.0056 0.0163 0.4424
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Brugia malayi Cadps2 protein 0.0056 0.0163 0.0233
Schistosoma mansoni z-protein (S1r protein) 0.042 0.1533 0.1533
Leishmania major hypothetical protein, conserved 0.0056 0.0163 0.4424
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0056 0.0163 0.1011
Loa Loa (eye worm) hypothetical protein 0.042 0.1533 0.1533
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.003 0.0066 0.0095
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0056 0.0163 0.0921
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0056 0.0163 0.8022
Echinococcus multilocularis actin binding protein anillin 0.0056 0.0163 0.0163
Loa Loa (eye worm) oxysterol binding protein 0.0056 0.0163 0.0163
Schistosoma mansoni aldehyde dehydrogenase 0.0107 0.0357 0.0357
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.003 0.0066 0.0946
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0056 0.0163 0.0163
Onchocerca volvulus 0.0058 0.0172 0.0894
Schistosoma mansoni zinc finger protein 0.0056 0.0163 0.0163
Trypanosoma cruzi hypothetical protein 0.0056 0.0163 0.8022
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0087 0.0282 0.0404
Trypanosoma cruzi PH domain containing protein, putative 0.0056 0.0163 0.8022
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0066 0.0201 0.5515
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0056 0.0163 0.1011
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Loa Loa (eye worm) PH domain-containing protein 0.0056 0.0163 0.0163
Brugia malayi hypothetical protein 0.0048 0.0134 0.0191
Leishmania major 4-coumarate:coa ligase-like protein 0.0018 0.0023 0.0419
Trichomonas vaginalis set domain proteins, putative 0.0459 0.1681 1
Echinococcus multilocularis beta 1 syntrophin 0.0056 0.0163 0.0163
Leishmania major folate/biopterin transporter, putative 0.0066 0.0201 0.5515
Schistosoma mansoni ran 0.0017 0.002 0.002
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0056 0.0163 0.0233
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0056 0.0163 0.0921
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.003 0.0066 0.0066
Echinococcus granulosus expressed protein 0.042 0.1533 0.1533
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0056 0.0163 0.0921
Loa Loa (eye worm) hypothetical protein 0.003 0.0066 0.0066
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Leishmania major 4-coumarate:coa ligase-like protein 0.0018 0.0023 0.0419
Echinococcus granulosus beta LACTamase domain containing family member 0.003 0.0066 0.0066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0087 0.0282 0.0282
Mycobacterium ulcerans hypothetical protein 0.003 0.0066 0.172
Onchocerca volvulus 0.0056 0.0163 0.0841
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Brugia malayi beta-lactamase family protein 0.003 0.0066 0.0095
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0056 0.0163 0.0233
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Trichomonas vaginalis protein transport protein sec7, putative 0.0056 0.0163 0.0921
Brugia malayi Variant SH3 domain containing protein 0.0056 0.0163 0.0233
Echinococcus multilocularis dynamin 1 0.0056 0.0163 0.0163
Entamoeba histolytica protein kinase, putative 0.0066 0.0201 0.126
Schistosoma mansoni serine/threonine protein kinase 0.267 1 1
Echinococcus multilocularis DCC interacting protein 13 beta 0.0056 0.0163 0.0163
Loa Loa (eye worm) uncoordinated protein 104 0.0056 0.0163 0.0163
Schistosoma mansoni ap endonuclease 0.0015 0.0009 0.0009
Brugia malayi Pleckstrin Homology Domain 0.0056 0.0163 0.0233
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.267 1 1
Loa Loa (eye worm) beta-lactamase 0.003 0.0066 0.0066
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0018 0.0023 0.05
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0056 0.0163 0.0921
Echinococcus granulosus oxysterol binding protein 9 0.0056 0.0163 0.0163
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0066 0.0201 1
Schistosoma mansoni regulator of G protein signaling 0.042 0.1533 0.1533
Brugia malayi PH domain containing protein 0.0056 0.0163 0.0233
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.003 0.0066 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0017 0.002 0.0028
Entamoeba histolytica hypothetical protein 0.0066 0.0201 0.126
Loa Loa (eye worm) hypothetical protein 0.0593 0.2186 0.2186
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0014 0.0006 0.0042
Mycobacterium leprae Probable lipase LipE 0.003 0.0066 1
Entamoeba histolytica protein kinase, putative 0.0066 0.0201 0.126
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Schistosoma mansoni regulator of G protein signaling 0.042 0.1533 0.1533
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0066 0.0201 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0107 0.0357 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.042 0.1533 0.1533
Loa Loa (eye worm) MH2 domain-containing protein 0.0113 0.0377 0.0377
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.042 0.1533 0.9111
Echinococcus granulosus regulator of G protein signaling 7 0.042 0.1533 0.1533
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0066 0.0343
Schistosoma mansoni ran 0.0017 0.002 0.002
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Brugia malayi hypothetical protein 0.0056 0.0163 0.0233
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0018 0.0023 0.0305
Schistosoma mansoni zinc finger protein 0.0056 0.0163 0.0163
Onchocerca volvulus outspread protein homolog 0.0056 0.0163 0.0841
Entamoeba histolytica acyl-CoA synthetase, putative 0.0018 0.0023 0.0096
Echinococcus multilocularis axis inhibition protein axin 0.042 0.1533 0.1533
Toxoplasma gondii ABC1 family protein 0.003 0.0066 0.165
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0056 0.0163 0.0163
Schistosoma mansoni hypothetical protein 0.0056 0.0163 0.0163
Trypanosoma cruzi hypothetical protein 0.0056 0.0163 0.8022
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Entamoeba histolytica protein kinase, putative 0.0066 0.0201 0.126
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0066 0.0201 0.1148
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0056 0.0163 0.1011
Onchocerca volvulus 0.0056 0.0163 0.0841
Brugia malayi regulator of G-protein signaling egl-10 0.042 0.1533 0.219
Echinococcus multilocularis G protein coupled receptor kinase 6 0.1452 0.542 0.542
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.003 0.0066 0.0946
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0006
Plasmodium vivax hypothetical protein, conserved 0.003 0.0066 0.3098
Schistosoma mansoni hypothetical protein 0.0056 0.0163 0.0163
Toxoplasma gondii aldehyde dehydrogenase 0.0107 0.0357 1
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Schistosoma mansoni hypothetical protein 0.014 0.0482 0.0482
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0056 0.0163 0.1011
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0056 0.0163 0.0163
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0017 0.002 0.056
Trichomonas vaginalis hypothetical protein 0.0056 0.0163 0.0921
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0056 0.0163 0.8053
Mycobacterium ulcerans aldehyde dehydrogenase 0.0107 0.0357 1
Schistosoma mansoni myotubularin-related protein 0.0056 0.0163 0.0163
Schistosoma mansoni serine/threonine protein kinase 0.267 1 1
Brugia malayi Oxysterol-binding protein 0.0056 0.0163 0.0233
Loa Loa (eye worm) hypothetical protein 0.003 0.0066 0.0066
Trypanosoma cruzi hypothetical protein 0.0056 0.0163 0.8022
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0026 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0026 0.0053 0.0053
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0056 0.0163 0.8053
Loa Loa (eye worm) hypothetical protein 0.003 0.0066 0.0066
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0066 0.0201 1
Echinococcus multilocularis importin subunit beta 1 0.0024 0.0043 0.0043
Leishmania major 4-coumarate:coa ligase-like protein 0.0018 0.0023 0.0419
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0056 0.0163 0.0163
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0066 0.0201 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0039 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0107 0.0357 0.0357
Echinococcus multilocularis calcium dependent secretion activator 1 0.0056 0.0163 0.0163
Plasmodium falciparum oxysterol-binding protein, putative 0.0056 0.0163 0.8053
Entamoeba histolytica protein kinase, putative 0.0066 0.0201 0.126
Echinococcus granulosus GRB2 associated binding protein 3 0.0056 0.0163 0.0163
Entamoeba histolytica PH domain containing protein 0.0056 0.0163 0.1011
Schistosoma mansoni axis inhibition protein axin 0.042 0.1533 0.1533
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0201 0.126
Schistosoma mansoni regulator of G protein signaling 0.042 0.1533 0.1533
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0056 0.0163 0.0163
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0056 0.0163 0.0163
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.1452 0.542 0.542
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0087 0.0282 0.0282
Entamoeba histolytica hypothetical protein 0.042 0.1533 1
Mycobacterium ulcerans hypothetical protein 0.0018 0.0023 0.05
Brugia malayi Plekhf2 protein 0.0056 0.0163 0.0233
Mycobacterium ulcerans lipase LipD 0.003 0.0066 0.172
Echinococcus granulosus Pleckstrin y 0.0056 0.0163 0.0163
Echinococcus granulosus oxysterol binding protein 1 0.0056 0.0163 0.0163
Leishmania major serine/threonine-protein kinase a, putative 0.0066 0.0201 0.5515
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0066 0.0201 0.5515
Onchocerca volvulus 0.003 0.0066 0.0258
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Schistosoma mansoni survival motor neuron protein 0.0077 0.0244 0.0244
Echinococcus granulosus survival motor neuron protein 1 0.0378 0.1377 0.1377
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0172 0.0172
Echinococcus granulosus pdz domain containing protein 0.0056 0.0163 0.0163
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0023 0.0033
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Trypanosoma cruzi PH domain containing protein, putative 0.0056 0.0163 0.8022
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0015 0.0009 0.0087
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0056 0.0163 0.0163
Brugia malayi PH domain containing protein 0.0056 0.0163 0.0233
Brugia malayi PH domain containing protein 0.0056 0.0163 0.0233
Brugia malayi PH domain containing protein 0.0056 0.0163 0.0233
Schistosoma mansoni hypothetical protein 0.0056 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Schistosoma mansoni oxysterol-binding protein 1 0.0056 0.0163 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Loa Loa (eye worm) hypothetical protein 0.042 0.1533 0.1533
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0056 0.0163 0.8022
Echinococcus granulosus pleckstrin y domain containing family A 0.0056 0.0163 0.0163
Brugia malayi A-kinase anchor protein 10, precursor 0.042 0.1533 0.219
Trichomonas vaginalis ran, putative 0.0017 0.002 0.0064
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0066 0.0201 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0087 0.0282 0.0282
Trichomonas vaginalis centaurin alpha, putative 0.0056 0.0163 0.0921
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.042 0.1533 0.1533
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Trypanosoma cruzi PH domain containing protein, putative 0.0056 0.0163 0.8022
Brugia malayi Muscleblind-like protein 0.0593 0.2186 0.3123
Onchocerca volvulus Putative zinc finger protein 0.0056 0.0163 0.0841
Entamoeba histolytica protein kinase, putative 0.0066 0.0201 0.126
Entamoeba histolytica hypothetical protein 0.0056 0.0163 0.1011
Entamoeba histolytica hypothetical protein 0.0019 0.0026 0.0114
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0017 0.002 0.056
Echinococcus multilocularis G protein coupled receptor kinase 1 0.225 0.8421 0.8421
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0056 0.0163 0.0163
Echinococcus granulosus calcium dependent secretion activator 1 0.0056 0.0163 0.0163
Brugia malayi Pre-SET motif family protein 0.0058 0.0172 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.042 0.1533 0.9111
Echinococcus multilocularis muscleblind protein 1 0.0593 0.2186 0.2186
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0172 0.0172
Brugia malayi RNA, U transporter 1 0.0067 0.0207 0.0296
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Trypanosoma brucei importin beta-1 subunit, putative 0.0024 0.0043 0.1785
Schistosoma mansoni serine/threonine-protein kinase 0.0066 0.0201 0.0201
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0056 0.0163 0.1011
Brugia malayi hypothetical protein 0.0031 0.007 0.01
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0056 0.0163 0.0921
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0018 0.0023 0.05
Brugia malayi Regulator of G protein signaling domain containing protein 0.042 0.1533 0.219
Trichomonas vaginalis alpha chimerin, putative 0.0056 0.0163 0.0921
Onchocerca volvulus 0.0056 0.0163 0.0841
Echinococcus multilocularis survival motor neuron protein 1 0.0378 0.1377 0.1377
Schistosoma mansoni centaurin alpha 0.0056 0.0163 0.0163
Schistosoma mansoni hypothetical protein 0.0253 0.0905 0.0905
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0056 0.0163 0.0163
Mycobacterium tuberculosis Conserved protein 0.003 0.0066 0.0946
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Trypanosoma cruzi PAB1-binding protein , putative 0.0048 0.0134 0.6505
Schistosoma mansoni regulator of G protein signaling 0.042 0.1533 0.1533
Trypanosoma brucei rac serine-threonine kinase, putative 0.0066 0.0201 1
Brugia malayi Uncoordinated protein 104 0.0056 0.0163 0.0233
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0066 0.0201 1
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Brugia malayi TBC domain containing protein 0.0056 0.0163 0.0233
Brugia malayi PXA domain containing protein 0.042 0.1533 0.219
Echinococcus multilocularis pdz domain containing protein 0.0056 0.0163 0.0163
Entamoeba histolytica PH domain containing protein 0.0056 0.0163 0.1011
Loa Loa (eye worm) hypothetical protein 0.0058 0.0172 0.0172
Plasmodium vivax ataxin-2 like protein, putative 0.0048 0.0134 0.6559
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.042 0.1533 0.1533
Echinococcus multilocularis regulator of G protein signaling 0.042 0.1533 0.1533
Onchocerca volvulus 0.0056 0.0163 0.0841
Echinococcus granulosus Pleckstrin y 0.0056 0.0163 0.0163
Entamoeba histolytica hypothetical protein, conserved 0.0056 0.0163 0.1011
Echinococcus granulosus snurportin 1 0.0253 0.0905 0.0905
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0056 0.0163 0.0163
Loa Loa (eye worm) PXA domain-containing protein 0.042 0.1533 0.1533
Echinococcus granulosus regulator of G protein signaling 3 0.042 0.1533 0.1533
Mycobacterium leprae conserved hypothetical protein 0.003 0.0066 1
Leishmania major hypothetical protein, conserved 0.0056 0.0163 0.4424
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0056 0.0163 0.8053
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0056 0.0163 0.8053
Trypanosoma brucei PAB1-binding protein , putative 0.0048 0.0134 0.6506
Mycobacterium tuberculosis Probable lipase LipE 0.003 0.0066 0.0946
Trypanosoma cruzi hypothetical protein 0.0056 0.0163 0.8022
Entamoeba histolytica hypothetical protein 0.042 0.1533 1
Trypanosoma cruzi NIMA-related kinase, putative 0.0066 0.0201 1
Echinococcus multilocularis Pleckstrin y 0.0056 0.0163 0.0163
Schistosoma mansoni hypothetical protein 0.0077 0.0244 0.0244
Brugia malayi regulator of G-protein signaling rgs-7 0.042 0.1533 0.219
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0023 0.05
Echinococcus multilocularis oxysterol binding protein 1 0.0056 0.0163 0.0163
Trypanosoma cruzi hypothetical protein 0.0056 0.0163 0.8022
Brugia malayi Importin beta-1 subunit 0.0024 0.0043 0.0062
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0066 0.2992
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.1452 0.542 0.542
Leishmania major importin beta-1 subunit, putative 0.0019 0.0026 0.05
Schistosoma mansoni aldehyde dehydrogenase 0.0107 0.0357 0.0357
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0201 0.126
Trichomonas vaginalis protein transport protein sec7, putative 0.0056 0.0163 0.0921
Loa Loa (eye worm) Plekhf2 protein 0.0056 0.0163 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Schistosoma mansoni regulator of G protein signaling 0.042 0.1533 0.1533
Trypanosoma brucei importin beta-1 subunit, putative 0.0024 0.0043 0.1785
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0066 0.0201 1
Mycobacterium tuberculosis Conserved protein 0.003 0.0066 0.0946
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Mycobacterium tuberculosis Probable conserved lipoprotein 0.003 0.0066 0.0946
Onchocerca volvulus 0.0459 0.1681 1
Onchocerca volvulus Protein melted homolog 0.0056 0.0163 0.0841
Trichomonas vaginalis conserved hypothetical protein 0.042 0.1533 0.9111
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0017 0.002 0.002
Echinococcus multilocularis Pleckstrin y 0.0056 0.0163 0.0163
Echinococcus granulosus Pleckstrin y 0.0056 0.0163 0.0163
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0164 0.0164
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0107 0.0357 0.5297
Toxoplasma gondii LsmAD domain-containing protein 0.0048 0.0134 0.3588
Brugia malayi Dynamin 0.0056 0.0163 0.0233
Loa Loa (eye worm) transcription factor SMAD2 0.0113 0.0377 0.0377
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0172 0.0172
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0018 0.0023 0.05
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0017 0.002 0.0703
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.042 0.1533 0.1533
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.042 0.1533 0.1533
Trypanosoma cruzi importin beta-1 subunit, putative 0.0019 0.0026 0.0907
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0023 0.05
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Echinococcus multilocularis GRB2 associated binding protein 3 0.0056 0.0163 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Echinococcus multilocularis rac serine:threonine kinase 0.0066 0.0201 0.0201
Echinococcus granulosus Oxysterol binding protein 11 0.0056 0.0163 0.0163
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0056 0.0163 0.0841
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0593 0.2186 0.2186
Trichomonas vaginalis penicillin-binding protein, putative 0.003 0.0066 0.0343
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Brugia malayi Dynamin 0.0056 0.0163 0.0233
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0056 0.0163 0.0163
Loa Loa (eye worm) RGS-3 protein 0.042 0.1533 0.1533
Echinococcus multilocularis cytohesin 1 0.0056 0.0163 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Trichomonas vaginalis conserved hypothetical protein 0.042 0.1533 0.9111
Echinococcus multilocularis Pleckstrin y 0.0056 0.0163 0.0163
Trichomonas vaginalis kinesin light chain, putative 0.0056 0.0163 0.0921
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0253 0.0905 0.0905
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1452 0.542 0.542
Brugia malayi Pre-SET motif family protein 0.0403 0.1472 0.2103
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.0172 0.0172
Brugia malayi PXA domain containing protein 0.042 0.1533 0.219
Brugia malayi latrophilin 2 splice variant baaae 0.0026 0.0053 0.0076
Brugia malayi hypothetical protein 0.042 0.1533 0.219
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0056 0.0163 0.1011
Echinococcus granulosus geminin 0.014 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Echinococcus granulosus regulator of G protein signaling 3 0.042 0.1533 0.1533
Echinococcus granulosus serine/threonine protein kinase 0.0066 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0378 0.1377 0.1377
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0107 0.0357 0.0357
Mycobacterium tuberculosis Conserved protein 0.003 0.0066 0.0946
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0172 0.0172
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Trichomonas vaginalis conserved hypothetical protein 0.042 0.1533 0.9111
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0056 0.0163 0.0163
Mycobacterium tuberculosis Probable lipase LipD 0.003 0.0066 0.0946
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0056 0.0163 0.1011
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1872 0.6998 1
Trichomonas vaginalis conserved hypothetical protein 0.042 0.1533 0.9111
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0201 0.126
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0056 0.0163 0.8053
Echinococcus granulosus muscleblind protein 0.0593 0.2186 0.2186
Loa Loa (eye worm) hypothetical protein 0.003 0.0066 0.0066
Plasmodium vivax SET domain protein, putative 0.0058 0.0172 0.8506
Schistosoma mansoni serine/threonine-protein kinase 0.0066 0.0201 0.0201
Mycobacterium tuberculosis Probable hydrolase 0.003 0.0066 0.0946
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0017 0.002 0.0703
Entamoeba histolytica hypothetical protein 0.0056 0.0163 0.1011
Loa Loa (eye worm) rho-GTPase-activating 0.0056 0.0163 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0201 0.126
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Brugia malayi beta-lactamase 0.003 0.0066 0.0095
Trypanosoma cruzi PH domain containing protein, putative 0.0056 0.0163 0.8022
Loa Loa (eye worm) cytohesin 3 0.0056 0.0163 0.0163
Echinococcus multilocularis beta LACTamase domain containing family member 0.003 0.0066 0.0066
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0056 0.0163 0.1011
Loa Loa (eye worm) hypothetical protein 0.042 0.1533 0.1533
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0009 0.0152
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0009 0.0152
Brugia malayi hypothetical protein 0.0378 0.1377 0.1967
Brugia malayi PH domain containing protein 0.0056 0.0163 0.0233
Leishmania major protein kinase, putative 0.0066 0.0201 0.5515
Loa Loa (eye worm) hypothetical protein 0.0039 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0172 0.0172
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0019 0.0026 0.0104
Plasmodium falciparum importin beta, putative 0.0024 0.0043 0.1909
Echinococcus granulosus Regulator of G protein signaling 20 0.042 0.1533 0.1533
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0056 0.0163 0.0163
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0403 0.1472 0.1472
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0056 0.0163 0.0233
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0066 0.0201 1
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Brugia malayi Calcitonin receptor-like protein seb-1 0.0039 0.0099 0.0142
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0056 0.0163 0.0163
Echinococcus multilocularis regulator of G protein signaling 3 0.042 0.1533 0.1533
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0014 0.0006 0.5
Trichomonas vaginalis importin beta-1, putative 0.0019 0.0026 0.0104
Brugia malayi Regulator of G protein signaling domain containing protein 0.042 0.1533 0.219
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0191 0.0671 1
Toxoplasma gondii protein kinase domain-containing protein 0.0066 0.0201 0.5515
Loa Loa (eye worm) hypothetical protein 0.042 0.1533 0.1533
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0172 0.4678
Echinococcus multilocularis regulator of G protein signaling 7 0.042 0.1533 0.1533
Onchocerca volvulus 0.0056 0.0163 0.0841
Schistosoma mansoni hypothetical protein 0.0056 0.0163 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Mycobacterium ulcerans aldehyde dehydrogenase 0.0107 0.0357 1
Schistosoma mansoni rho gtpase activating protein 0.0056 0.0163 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Echinococcus granulosus GTP binding nuclear protein Ran 0.0017 0.002 0.002
Onchocerca volvulus 0.0077 0.0244 0.1332
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0056 0.0163 0.0163
Echinococcus multilocularis Oxysterol binding protein 11 0.0056 0.0163 0.0163
Echinococcus granulosus regulator of G protein signaling 7 0.042 0.1533 0.1533
Leishmania major protein kinase, putative 0.0066 0.0201 0.5515
Plasmodium falciparum ataxin-2 like protein, putative 0.0048 0.0134 0.6559
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Plasmodium vivax importin-beta 2, putative 0.0024 0.0043 0.1909
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0087 0.0282 0.0282
Brugia malayi hypothetical protein 0.042 0.1533 0.219
Brugia malayi PH domain containing protein 0.0056 0.0163 0.0233
Trypanosoma cruzi Protein kinase B 0.0066 0.0201 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0024 0.0043 0.0043
Brugia malayi Protein kinase domain containing protein 0.0066 0.0201 0.0287
Loa Loa (eye worm) hypothetical protein 0.003 0.0066 0.0066
Echinococcus granulosus axis inhibition protein axin 0.042 0.1533 0.1533
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0017 0.002 0.002
Leishmania major hypothetical protein, conserved 0.003 0.0066 0.165
Plasmodium falciparum ataxin-2 like protein, putative 0.0048 0.0134 0.6559
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.042 0.1533 0.1533
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0056 0.0163 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.003 0.0066 0.172
Brugia malayi PH domain containing protein 0.0056 0.0163 0.0233
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0009 0.0009
Leishmania major hypothetical protein, conserved 0.0048 0.0134 0.3588

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 3 % Inhibition of IL-6-stimulated STAT3 activation in human THP1 cells at 100 uM incubated for 30 mins prior to IL-6 stimulation measured after 15 mins by EMSA relative to control ChEMBL. 23287056

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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