Detailed information for compound 1771041

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 445.55 | Formula: C28H31NO4
  • H donors: 0 H acceptors: 1 LogP: 6.56 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c1c(C)ccc(c1n2CCCCCOc1ccccc1C(=O)OC)C
  • InChi: 1S/C28H31NO4/c1-19-12-13-20(2)27-26(19)23-18-21(31-3)14-15-24(23)29(27)16-8-5-9-17-33-25-11-7-6-10-22(25)28(30)32-4/h6-7,10-15,18H,5,8-9,16-17H2,1-4H3
  • InChiKey: JSAMVPZPEFBLQJ-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0087 0.0282 0.0404
Echinococcus multilocularis muscleblind protein 0.0593 0.2186 0.2186
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Onchocerca volvulus 0.003 0.0066 0.0258
Mycobacterium tuberculosis Probable lipase LipD 0.003 0.0066 0.0946
Echinococcus multilocularis muscleblind protein 1 0.0593 0.2186 0.2186
Entamoeba histolytica hypothetical protein, conserved 0.0056 0.0163 0.1011
Onchocerca volvulus Putative zinc finger protein 0.0056 0.0163 0.0841
Trichomonas vaginalis conserved hypothetical protein 0.042 0.1533 0.9111
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0077 0.0244 0.0349
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0023 0.05
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0107 0.0357 0.0357
Echinococcus multilocularis oxysterol binding protein 3 0.0056 0.0163 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Brugia malayi MAX-1A 0.0056 0.0163 0.0233
Brugia malayi Cytohesin 3 0.0056 0.0163 0.0233
Onchocerca volvulus 0.0056 0.0163 0.0841
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.042 0.1533 0.1533
Brugia malayi beta-lactamase 0.003 0.0066 0.0095
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0056 0.0163 0.0163
Schistosoma mansoni z-protein (S1r protein) 0.042 0.1533 0.1533
Trypanosoma cruzi hypothetical protein 0.0056 0.0163 0.8022
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.267 1 1
Echinococcus granulosus GRB2 associated binding protein 3 0.0056 0.0163 0.0163
Entamoeba histolytica PH domain containing protein 0.0056 0.0163 0.1011
Toxoplasma gondii HEAT repeat-containing protein 0.0024 0.0043 0.0984
Echinococcus multilocularis Ras associated and pleckstrin y 0.0056 0.0163 0.0163
Echinococcus multilocularis DCC interacting protein 13 beta 0.0056 0.0163 0.0163
Schistosoma mansoni oxysterol-binding protein 1 0.0056 0.0163 0.0163
Leishmania major protein kinase, putative 0.0066 0.0201 0.5515
Echinococcus multilocularis G protein coupled receptor kinase 6 0.1452 0.542 0.542
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0056 0.0163 0.0841
Echinococcus granulosus snurportin 1 0.0253 0.0905 0.0905
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0087 0.0282 0.0282
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0191 0.0671 1
Entamoeba histolytica protein kinase, putative 0.0066 0.0201 0.126
Onchocerca volvulus outspread protein homolog 0.0056 0.0163 0.0841
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.003 0.0066 0.172
Mycobacterium ulcerans beta-lactamase 0.003 0.0066 0.172
Brugia malayi PXA domain containing protein 0.042 0.1533 0.219
Entamoeba histolytica hypothetical protein 0.0056 0.0163 0.1011
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0056 0.0163 0.1011
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0018 0.0023 0.05
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.042 0.1533 0.9111
Trypanosoma cruzi PH domain containing protein, putative 0.0056 0.0163 0.8022
Trypanosoma cruzi hypothetical protein 0.0056 0.0163 0.8022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0006
Brugia malayi latrophilin 2 splice variant baaae 0.0026 0.0053 0.0076
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.042 0.1533 0.1533
Brugia malayi Dynamin 0.0056 0.0163 0.0233
Mycobacterium tuberculosis Conserved protein 0.003 0.0066 0.0946
Mycobacterium ulcerans hypothetical protein 0.0018 0.0023 0.05
Trypanosoma brucei importin beta-1 subunit, putative 0.0024 0.0043 0.1785
Entamoeba histolytica acyl-CoA synthetase, putative 0.0018 0.0023 0.0096
Leishmania major 4-coumarate:coa ligase-like protein 0.0018 0.0023 0.0419
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0066 0.0201 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0015 0.0009 0.0084
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0056 0.0163 0.0163
Brugia malayi Importin beta-1 subunit 0.0024 0.0043 0.0062
Schistosoma mansoni hypothetical protein 0.0026 0.0053 0.0053
Loa Loa (eye worm) PH domain-containing protein 0.0056 0.0163 0.0163
Leishmania major hypothetical protein, conserved 0.0056 0.0163 0.4424
Leishmania major GTP-binding protein, putative 0.0017 0.002 0.0309
Brugia malayi Oxysterol binding protein 0.0056 0.0163 0.0233
Schistosoma mansoni goodpasture antigen-binding protein 0.0056 0.0163 0.0163
Brugia malayi PH domain containing protein 0.0056 0.0163 0.0233
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Plasmodium falciparum oxysterol-binding protein, putative 0.0056 0.0163 0.8053
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0023
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0056 0.0163 0.1011
Echinococcus granulosus cytohesin 1 0.0056 0.0163 0.0163
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0201 0.126
Trichomonas vaginalis penicillin-binding protein, putative 0.003 0.0066 0.0343
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0066 0.0201 1
Trichomonas vaginalis centaurin alpha, putative 0.0056 0.0163 0.0921
Echinococcus multilocularis Pleckstrin y 0.0056 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Entamoeba histolytica acyl-coA synthetase, putative 0.0018 0.0023 0.0096
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1872 0.6998 0.6998
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Toxoplasma gondii ABC1 family protein 0.003 0.0066 0.165
Schistosoma mansoni regulator of G protein signaling 0.042 0.1533 0.1533
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0056 0.0163 0.0163
Mycobacterium ulcerans esterase/lipase LipP 0.003 0.0066 0.172
Loa Loa (eye worm) hypothetical protein 0.042 0.1533 0.1533
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0066 0.0201 1
Echinococcus granulosus pdz domain containing protein 0.0056 0.0163 0.0163
Brugia malayi Uncoordinated protein 104 0.0056 0.0163 0.0233
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0018 0.0023 0.05
Schistosoma mansoni serine/threonine protein kinase 0.267 1 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0018 0.0023 0.05
Schistosoma mansoni myotubularin-related protein 0.0056 0.0163 0.0163
Echinococcus multilocularis axis inhibition protein axin 0.042 0.1533 0.1533
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0009 0.0009
Onchocerca volvulus 0.003 0.0066 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.042 0.1533 0.9111
Loa Loa (eye worm) cytohesin 3 0.0056 0.0163 0.0163
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0087 0.0282 0.0282
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0056 0.0163 0.8053
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Trypanosoma brucei PH domain containing protein, putative 0.0056 0.0163 0.8023
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Leishmania major hypothetical protein, conserved 0.0056 0.0163 0.4424
Entamoeba histolytica hypothetical protein 0.0056 0.0163 0.1011
Schistosoma mansoni hypothetical protein 0.014 0.0482 0.0482
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1872 0.6998 1
Loa Loa (eye worm) hypothetical protein 0.0593 0.2186 0.2186
Echinococcus multilocularis survival motor neuron protein 1 0.0378 0.1377 0.1377
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0056 0.0163 0.0163
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0066 0.0201 0.1148
Echinococcus multilocularis regulator of G protein signaling 7 0.042 0.1533 0.1533
Trichomonas vaginalis ran, putative 0.0017 0.002 0.0064
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0056 0.0163 0.0921
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.0172 0.0172
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Brugia malayi Regulator of G protein signaling domain containing protein 0.042 0.1533 0.219
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0066 0.0201 1
Mycobacterium tuberculosis Conserved protein 0.003 0.0066 0.0946
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Brugia malayi RNA, U transporter 1 0.0067 0.0207 0.0296
Schistosoma mansoni ran 0.0017 0.002 0.002
Toxoplasma gondii phosphatidylinositol transfer protein 0.0056 0.0163 0.4424
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0107 0.0357 0.0357
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.042 0.1533 0.1533
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0201 0.126
Plasmodium falciparum PH domain-containing protein, putative 0.0056 0.0163 0.8053
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0056 0.0163 0.0163
Trypanosoma brucei PAB1-binding protein , putative 0.0048 0.0134 0.6506
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0056 0.0163 0.0921
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0087 0.0282 0.0282
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0066 0.0201 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0024 0.0043 0.1785
Echinococcus granulosus regulator of G protein signaling 7 0.042 0.1533 0.1533
Brugia malayi hypothetical protein 0.042 0.1533 0.219
Echinococcus granulosus axis inhibition protein axin 0.042 0.1533 0.1533
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Plasmodium vivax SET domain protein, putative 0.0058 0.0172 0.8506
Echinococcus multilocularis Oxysterol binding protein 11 0.0056 0.0163 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0023 0.05
Trypanosoma brucei rac serine-threonine kinase, putative 0.0066 0.0201 1
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Trichomonas vaginalis kinesin light chain, putative 0.0056 0.0163 0.0921
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0066 0.0201 0.5515
Onchocerca volvulus 0.0056 0.0163 0.0841
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0056 0.0163 0.0163
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0021 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0087 0.0282 0.0282
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0201 0.126
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0056 0.0163 0.0921
Echinococcus granulosus serine/threonine protein kinase 0.0066 0.0201 0.0201
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0403 0.1472 0.1472
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0107 0.0357 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0009 0.0152
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Brugia malayi Syntrophin-1 0.0056 0.0163 0.0233
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1452 0.542 0.542
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Schistosoma mansoni hypothetical protein 0.0056 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.042 0.1533 0.1533
Loa Loa (eye worm) RGS-3 protein 0.042 0.1533 0.1533
Echinococcus multilocularis calcium dependent secretion activator 1 0.0056 0.0163 0.0163
Brugia malayi Pre-SET motif family protein 0.0403 0.1472 0.2103
Loa Loa (eye worm) hypothetical protein 0.042 0.1533 0.1533
Loa Loa (eye worm) hypothetical protein 0.0378 0.1377 0.1377
Schistosoma mansoni regulator of G protein signaling 0.042 0.1533 0.1533
Onchocerca volvulus 0.0077 0.0244 0.1332
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0066 0.0201 1
Brugia malayi PH domain containing protein 0.0056 0.0163 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Schistosoma mansoni hypothetical protein 0.0077 0.0244 0.0244
Onchocerca volvulus 0.0056 0.0163 0.0841
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0056 0.0163 0.0163
Echinococcus granulosus survival motor neuron protein 1 0.0378 0.1377 0.1377
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0066 0.0201 1
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0056 0.0163 0.1011
Echinococcus granulosus Pleckstrin y 0.0056 0.0163 0.0163
Schistosoma mansoni importin beta-1 0.0024 0.0043 0.0043
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0017 0.002 0.0703
Trichomonas vaginalis conserved hypothetical protein 0.042 0.1533 0.9111
Echinococcus granulosus Regulator of G protein signaling 20 0.042 0.1533 0.1533
Entamoeba histolytica hypothetical protein 0.0066 0.0201 0.126
Schistosoma mansoni serine/threonine-protein kinase 0.0066 0.0201 0.0201
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0056 0.0163 0.0163
Mycobacterium tuberculosis Probable hydrolase 0.003 0.0066 0.0946
Schistosoma mansoni goodpasture antigen-binding protein 0.0056 0.0163 0.0163
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0056 0.0163 0.0163
Plasmodium vivax importin-beta 2, putative 0.0024 0.0043 0.1909
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.003 0.0066 0.0946
Trypanosoma cruzi PH domain containing protein, putative 0.0056 0.0163 0.8022
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0056 0.0163 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0056 0.0163 0.8022
Treponema pallidum exodeoxyribonuclease (exoA) 0.0015 0.0009 0.5
Entamoeba histolytica PH domain containing protein 0.0056 0.0163 0.1011
Schistosoma mansoni zinc finger protein 0.0056 0.0163 0.0163
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.042 0.1533 0.1533
Echinococcus multilocularis G protein coupled receptor kinase 1 0.225 0.8421 0.8421
Echinococcus multilocularis beta 1 syntrophin 0.0056 0.0163 0.0163
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0039 0.0099 0.0099
Mycobacterium tuberculosis Probable conserved lipoprotein 0.003 0.0066 0.0946
Loa Loa (eye worm) hypothetical protein 0.0026 0.0053 0.0053
Entamoeba histolytica acyl-CoA synthetase, putative 0.0018 0.0023 0.0096
Mycobacterium leprae Probable lipase LipE 0.003 0.0066 1
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.1452 0.542 0.542
Mycobacterium ulcerans aldehyde dehydrogenase 0.0107 0.0357 1
Echinococcus multilocularis oxysterol binding protein 9 0.0056 0.0163 0.0163
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0056 0.0163 0.8053
Schistosoma mansoni oxysterol-binding protein 1 0.0056 0.0163 0.0163
Schistosoma mansoni regulator of G protein signaling 0.042 0.1533 0.1533
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0066 0.2992
Entamoeba histolytica Ran family GTPase 0.0017 0.002 0.0071
Loa Loa (eye worm) AGC/AKT protein kinase 0.0066 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.042 0.1533 0.1533
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0056 0.0163 0.1011
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.042 0.1533 0.1533
Onchocerca volvulus 0.0459 0.1681 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0087 0.0282 0.0282
Loa Loa (eye worm) rho-GTPase-activating 0.0056 0.0163 0.0163
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0056 0.0163 0.0233
Schistosoma mansoni zinc finger protein 0.0056 0.0163 0.0163
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0017 0.002 0.0028
Loa Loa (eye worm) hypothetical protein 0.0024 0.0043 0.0043
Schistosoma mansoni centaurin alpha 0.0056 0.0163 0.0163
Trichomonas vaginalis protein transport protein sec7, putative 0.0056 0.0163 0.0921
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Schistosoma mansoni serine/threonine protein kinase 0.267 1 1
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0056 0.0163 0.1011
Mycobacterium tuberculosis Probable lipase LipE 0.003 0.0066 0.0946
Echinococcus granulosus G protein coupled receptor kinase 1 0.225 0.8421 0.8421
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0017 0.002 0.0703
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0056 0.0163 0.1011
Echinococcus multilocularis expressed protein 0.042 0.1533 0.1533
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0056 0.0163 0.1011
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0066 0.2992
Echinococcus granulosus dynamin 1 0.0056 0.0163 0.0163
Brugia malayi regulator of G-protein signaling rgs-7 0.042 0.1533 0.219
Toxoplasma gondii Oxysterol-binding protein 0.0056 0.0163 0.4424
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0087 0.0282 0.0282
Schistosoma mansoni dynamin 0.0056 0.0163 0.0163
Brugia malayi A-kinase anchor protein 10, precursor 0.042 0.1533 0.219
Trypanosoma cruzi hypothetical protein 0.0056 0.0163 0.8022
Echinococcus multilocularis dynamin 1 0.0056 0.0163 0.0163
Echinococcus granulosus regulator of G protein signaling 7 0.042 0.1533 0.1533
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0017 0.002 0.056
Brugia malayi hypothetical protein 0.0031 0.007 0.01
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0017 0.002 0.056
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0056 0.0163 0.1011
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Brugia malayi beta-lactamase family protein 0.003 0.0066 0.0095
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0066 0.0201 1
Toxoplasma gondii hypothetical protein 0.0056 0.0163 0.4424
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0172 0.4678
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Trypanosoma cruzi hypothetical protein 0.0056 0.0163 0.8022
Entamoeba histolytica hypothetical protein 0.0056 0.0163 0.1011
Plasmodium falciparum ataxin-2 like protein, putative 0.0048 0.0134 0.6559
Echinococcus multilocularis snurportin 1 0.0253 0.0905 0.0905
Echinococcus granulosus muscleblind protein 0.0593 0.2186 0.2186
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.003 0.0066 0.0095
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0066 0.0343
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0172 0.0172
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0019 0.0026 0.0104
Loa Loa (eye worm) syntrophin-1 0.0056 0.0163 0.0163
Loa Loa (eye worm) Plekhf2 protein 0.0056 0.0163 0.0163
Schistosoma mansoni axis inhibition protein axin 0.042 0.1533 0.1533
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.042 0.1533 0.1533
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Plasmodium falciparum importin beta, putative 0.0024 0.0043 0.1909
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0056 0.0163 0.8053
Loa Loa (eye worm) hypothetical protein 0.003 0.0066 0.0066
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0087 0.0282 0.0282
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0056 0.0163 0.8022
Trypanosoma cruzi NIMA-related kinase, putative 0.0066 0.0201 1
Echinococcus granulosus axis inhibition protein axin 0.042 0.1533 0.1533
Echinococcus multilocularis regulator of G protein signaling 0.042 0.1533 0.1533
Echinococcus granulosus beta LACTamase domain containing family member 0.003 0.0066 0.0066
Echinococcus multilocularis Rho GTPase activating protein 24 0.0056 0.0163 0.0163
Entamoeba histolytica protein kinase, putative 0.0066 0.0201 0.126
Mycobacterium ulcerans aldehyde dehydrogenase 0.0107 0.0357 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0201 0.126
Echinococcus granulosus Pleckstrin y 0.0056 0.0163 0.0163
Echinococcus multilocularis importin subunit beta 1 0.0024 0.0043 0.0043
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Schistosoma mansoni regulator of G protein signaling 0.042 0.1533 0.1533
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0017 0.002 0.056
Onchocerca volvulus 0.003 0.0066 0.0258
Mycobacterium leprae conserved hypothetical protein 0.003 0.0066 1
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Loa Loa (eye worm) PXA domain-containing protein 0.042 0.1533 0.1533
Toxoplasma gondii protein kinase domain-containing protein 0.0066 0.0201 0.5515
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0066 0.0201 1
Schistosoma mansoni vav2 0.0056 0.0163 0.0163
Schistosoma mansoni serine/threonine protein kinase 0.1872 0.6998 0.6998
Echinococcus multilocularis cytohesin 1 0.0056 0.0163 0.0163
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0018 0.0023 0.0305
Entamoeba histolytica hypothetical protein 0.0019 0.0026 0.0114
Leishmania major 4-coumarate:coa ligase-like protein 0.0018 0.0023 0.0419
Schistosoma mansoni hypothetical protein 0.014 0.0482 0.0482
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0056 0.0163 0.0841
Entamoeba histolytica hypothetical protein 0.0056 0.0163 0.1011
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0021 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0066 0.0201 1
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Trichomonas vaginalis esterase, putative 0.003 0.0066 0.0343
Trichomonas vaginalis penicillin-binding protein, putative 0.003 0.0066 0.0343
Loa Loa (eye worm) hypothetical protein 0.042 0.1533 0.1533
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1452 0.542 0.7744
Echinococcus granulosus oxysterol binding protein 1 0.0056 0.0163 0.0163
Toxoplasma gondii hypothetical protein 0.0056 0.0163 0.4424
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0039 0.0099 0.0142
Trypanosoma cruzi hypothetical protein 0.0056 0.0163 0.8022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0172 0.0172
Loa Loa (eye worm) transcription factor SMAD2 0.0113 0.0377 0.0377
Plasmodium falciparum ataxin-2 like protein, putative 0.0048 0.0134 0.6559
Toxoplasma gondii AtPH1 family protein 0.0056 0.0163 0.4424
Trypanosoma cruzi PAB1-binding protein , putative 0.0048 0.0134 0.6505
Toxoplasma gondii LsmAD domain-containing protein 0.0048 0.0134 0.3588
Echinococcus granulosus oxysterol binding protein 3 0.0056 0.0163 0.0163
Echinococcus multilocularis geminin 0.014 0.0482 0.0482
Echinococcus granulosus beta 1 syntrophin 0.0056 0.0163 0.0163
Schistosoma mansoni hypothetical protein 0.0021 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0066 0.2992
Plasmodium vivax ataxin-2 like protein, putative 0.0048 0.0134 0.6559
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.003 0.0066 0.0066
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0023 0.05
Schistosoma mansoni hypothetical protein 0.0056 0.0163 0.0163
Echinococcus multilocularis Pleckstrin y 0.0056 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Entamoeba histolytica PH domain containing protein 0.0056 0.0163 0.1011
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0253 0.0905 0.0905
Trichomonas vaginalis alpha chimerin, putative 0.0056 0.0163 0.0921
Brugia malayi PXA domain containing protein 0.042 0.1533 0.219
Echinococcus granulosus expressed protein 0.042 0.1533 0.1533
Loa Loa (eye worm) oxysterol binding protein 0.0056 0.0163 0.0163
Echinococcus multilocularis pleckstrin y domain containing family A 0.0056 0.0163 0.0163
Echinococcus multilocularis GRB2 associated binding protein 3 0.0056 0.0163 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Brugia malayi regulator of G-protein signaling egl-10 0.042 0.1533 0.219
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0172 0.0172
Echinococcus multilocularis beta adrenergic receptor kinase 0.267 1 1
Echinococcus granulosus regulator of G protein signaling 3 0.042 0.1533 0.1533
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0056 0.0163 0.8053
Mycobacterium ulcerans hypothetical protein 0.003 0.0066 0.172
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.003 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Toxoplasma gondii aldehyde dehydrogenase 0.0107 0.0357 1
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0066 0.0201 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Entamoeba histolytica hypothetical protein 0.042 0.1533 1
Brugia malayi Variant SH3 domain containing protein 0.0056 0.0163 0.0233
Trypanosoma cruzi importin beta-1 subunit, putative 0.0019 0.0026 0.0907
Schistosoma mansoni hypothetical protein 0.0253 0.0905 0.0905
Echinococcus multilocularis beta LACTamase domain containing family member 0.003 0.0066 0.0066
Entamoeba histolytica protein kinase, putative 0.0066 0.0201 0.126
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0056 0.0163 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0066 0.0201 1
Brugia malayi hypothetical protein 0.0056 0.0163 0.0233
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Leishmania major importin beta-1 subunit, putative 0.0019 0.0026 0.05
Brugia malayi hypothetical protein 0.042 0.1533 0.219
Onchocerca volvulus 0.0056 0.0163 0.0841
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0009 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0172 0.0172
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0009 0.0009
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0023 0.05
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0056 0.0163 0.0163
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0107 0.0357 0.5297
Loa Loa (eye worm) beta-lactamase 0.003 0.0066 0.0066
Trichomonas vaginalis centaurin/arf, putative 0.0056 0.0163 0.0921
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0066 0.0201 0.1148
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0014 0.0006 0.0042
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0066 0.0201 1
Echinococcus multilocularis pdz domain containing protein 0.0056 0.0163 0.0163
Mycobacterium ulcerans lipase LipD 0.003 0.0066 0.172
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0201 0.126
Trichomonas vaginalis centaurin/arf, putative 0.0056 0.0163 0.0921
Trypanosoma cruzi Protein kinase B 0.0066 0.0201 1
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0056 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.003 0.0066 0.0066
Leishmania major folate/biopterin transporter, putative 0.0066 0.0201 0.5515
Loa Loa (eye worm) MH2 domain-containing protein 0.0113 0.0377 0.0377
Trichomonas vaginalis importin beta-1, putative 0.0019 0.0026 0.0104
Brugia malayi PH domain containing protein 0.0056 0.0163 0.0233
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0056 0.0163 0.0233
Schistosoma mansoni ap endonuclease 0.0015 0.0009 0.0009
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0056 0.0163 0.0163
Brugia malayi Protein kinase domain containing protein 0.0066 0.0201 0.0287
Echinococcus multilocularis rac serine:threonine kinase 0.0066 0.0201 0.0201
Echinococcus granulosus myotubularin protein 13 0.0056 0.0163 0.0163
Brugia malayi Muscleblind-like protein 0.0593 0.2186 0.3123
Leishmania major hypothetical protein, conserved 0.003 0.0066 0.165
Trypanosoma cruzi PAB1-binding protein , putative 0.0048 0.0134 0.6505
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0056 0.0163 0.8022
Trypanosoma cruzi hypothetical protein 0.0056 0.0163 0.8022
Leishmania major 4-coumarate:coa ligase-like protein 0.0018 0.0023 0.0419
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0066 0.0201 0.5515
Loa Loa (eye worm) hypothetical protein 0.003 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0006
Echinococcus granulosus DCC interacting protein 13 beta 0.0056 0.0163 0.0163
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.003 0.0066 0.0946
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.003 0.0066 0.0066
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0056 0.0163 0.1011
Brugia malayi Calcitonin receptor-like protein seb-1 0.0039 0.0099 0.0142
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0056 0.0163 0.0163
Entamoeba histolytica p21-activated kinase 0.0066 0.0201 0.126
Trichomonas vaginalis conserved hypothetical protein 0.042 0.1533 0.9111
Loa Loa (eye worm) hypothetical protein 0.0039 0.0099 0.0099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.003 0.0066 0.0066
Schistosoma mansoni rho gtpase activating protein 0.0056 0.0163 0.0163
Trichomonas vaginalis set domain proteins, putative 0.0459 0.1681 1
Trypanosoma brucei protein kinase, putative 0.0066 0.0201 1
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0066 0.0201 0.5515
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0056 0.0163 0.1011
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Brugia malayi PH domain containing protein 0.0056 0.0163 0.0233
Trichomonas vaginalis protein transport protein sec7, putative 0.0056 0.0163 0.0921
Onchocerca volvulus 0.0058 0.0172 0.0894
Echinococcus granulosus geminin 0.014 0.0482 0.0482
Brugia malayi beta-lactamase family protein 0.003 0.0066 0.0095
Onchocerca volvulus 0.0056 0.0163 0.0841
Trypanosoma cruzi hypothetical protein 0.0056 0.0163 0.8022
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0017 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0056 0.0163 0.0163
Plasmodium vivax hypothetical protein, conserved 0.0056 0.0163 0.8053
Entamoeba histolytica ARF GTPase activating protein, putative 0.0056 0.0163 0.1011
Onchocerca volvulus Protein melted homolog 0.0056 0.0163 0.0841
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.0009 0.0013
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0056 0.0163 0.0163
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0056 0.0163 0.8053
Loa Loa (eye worm) hypothetical protein 0.003 0.0066 0.0066
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Echinococcus multilocularis oxysterol binding protein 1 0.0056 0.0163 0.0163
Entamoeba histolytica protein kinase, putative 0.0066 0.0201 0.126
Echinococcus multilocularis Pleckstrin y 0.0056 0.0163 0.0163
Entamoeba histolytica hypothetical protein 0.0056 0.0163 0.1011
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0066 0.0201 1
Brugia malayi hypothetical protein 0.0048 0.0134 0.0191
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0066 0.0343
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.042 0.1533 0.9111
Echinococcus multilocularis regulator of G protein signaling 3 0.042 0.1533 0.1533
Brugia malayi PH domain containing protein 0.0056 0.0163 0.0233
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Loa Loa (eye worm) hypothetical protein 0.042 0.1533 0.1533
Brugia malayi Regulator of G protein signaling domain containing protein 0.042 0.1533 0.219
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0017 0.002 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0107 0.0357 1
Onchocerca volvulus 0.0056 0.0163 0.0841
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0087 0.0282 0.0282
Entamoeba histolytica protein kinase, putative 0.0066 0.0201 0.126
Mycobacterium tuberculosis Probable esterase LipL 0.003 0.0066 0.0946
Trichomonas vaginalis centaurin gamma, putative 0.0056 0.0163 0.0921
Brugia malayi hypothetical protein 0.0378 0.1377 0.1967
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0056 0.0163 0.0921
Loa Loa (eye worm) uncoordinated protein 104 0.0056 0.0163 0.0163
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0056 0.0163 0.0163
Brugia malayi PH domain containing protein 0.0056 0.0163 0.0233
Brugia malayi PH domain containing protein 0.0056 0.0163 0.0233
Leishmania major hypothetical protein, conserved 0.0048 0.0134 0.3588
Echinococcus multilocularis myotubularin protein 13 0.0056 0.0163 0.0163
Entamoeba histolytica hypothetical protein 0.042 0.1533 1
Trichomonas vaginalis centaurin beta, putative 0.0056 0.0163 0.0921
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0023 0.0033
Brugia malayi PH domain containing protein 0.0056 0.0163 0.0233
Brugia malayi TBC domain containing protein 0.0056 0.0163 0.0233
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0056 0.0163 0.0163
Schistosoma mansoni hypothetical protein 0.0056 0.0163 0.0163
Brugia malayi probable spectrin beta chain 0.0056 0.0163 0.0233
Schistosoma mansoni aldehyde dehydrogenase 0.0107 0.0357 0.0357
Echinococcus granulosus Oxysterol binding protein 11 0.0056 0.0163 0.0163
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0201 0.126
Echinococcus granulosus Rho GTPase activating protein 24 0.0056 0.0163 0.0163
Brugia malayi Oxysterol-binding protein 0.0056 0.0163 0.0233
Echinococcus granulosus oxysterol binding protein 9 0.0056 0.0163 0.0163
Brugia malayi MH2 domain containing protein 0.0113 0.0377 0.0539
Plasmodium falciparum calcium-dependent protein kinase 7 0.0066 0.0201 1
Echinococcus multilocularis regulator of G protein signaling 3 0.042 0.1533 0.1533
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0056 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0023 0.0033
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0009 0.0152
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0066 0.0343
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Echinococcus granulosus regulator of G protein signaling 3 0.042 0.1533 0.1533
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0056 0.0163 0.0163
Brugia malayi Pleckstrin Homology Domain 0.0056 0.0163 0.0233
Schistosoma mansoni ap endonuclease 0.0015 0.0009 0.0009
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0017 0.002 0.002
Echinococcus granulosus pleckstrin y domain containing family A 0.0056 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Schistosoma mansoni survival motor neuron protein 0.0077 0.0244 0.0244
Brugia malayi Variant SH3 domain containing protein 0.0056 0.0163 0.0233
Leishmania major serine/threonine-protein kinase a, putative 0.0066 0.0201 0.5515
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0023
Trypanosoma cruzi NIMA-related kinase, putative 0.0066 0.0201 1
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Schistosoma mansoni syntrophin 0.0056 0.0163 0.0163
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0056 0.0163 0.1011
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0172 0.0172
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0015 0.0009 0.5
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0056 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0593 0.2186 0.2186
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0015 0.0009 0.0087
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0056 0.0163 0.8053
Loa Loa (eye worm) hypothetical protein 0.0048 0.0134 0.0134
Brugia malayi Pre-SET motif family protein 0.0058 0.0172 0.0245
Entamoeba histolytica protein kinase, putative 0.0066 0.0201 0.126
Loa Loa (eye worm) hypothetical protein 0.003 0.0066 0.0066
Echinococcus granulosus GTP binding nuclear protein Ran 0.0017 0.002 0.002
Schistosoma mansoni aldehyde dehydrogenase 0.0107 0.0357 0.0357
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0172 0.0172
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Brugia malayi Plekhf2 protein 0.0056 0.0163 0.0233
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Leishmania major protein kinase, putative 0.0066 0.0201 0.5515
Echinococcus multilocularis actin binding protein anillin 0.0056 0.0163 0.0163
Brugia malayi Dynamin 0.0056 0.0163 0.0233
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0056 0.0163 0.0921
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0023 0.0305
Schistosoma mansoni regulator of G protein signaling 0.042 0.1533 0.1533
Plasmodium vivax PH domain containing protein 0.0056 0.0163 0.8053
Schistosoma mansoni hypothetical protein 0.0056 0.0163 0.0163
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.1452 0.542 0.542
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0014 0.0006 0.5
Brugia malayi PH domain containing protein 0.0056 0.0163 0.0233
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0056 0.0163 0.0163
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0019 0.0026 0.0104
Echinococcus granulosus Pleckstrin y 0.0056 0.0163 0.0163
Plasmodium vivax hypothetical protein, conserved 0.003 0.0066 0.3098
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0056 0.0163 0.0163
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0017 0.002 0.0309
Trypanosoma cruzi PH domain containing protein, putative 0.0056 0.0163 0.8022
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0056 0.0163 0.0163
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0056 0.0163 0.1011
Schistosoma mansoni dynamin 0.0056 0.0163 0.0163
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0023 0.0033
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Trypanosoma cruzi PH domain containing protein, putative 0.0056 0.0163 0.8022
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Trichomonas vaginalis conserved hypothetical protein 0.042 0.1533 0.9111
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0056 0.0163 0.1011
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Schistosoma mansoni axis inhibition protein axin 0.042 0.1533 0.1533
Entamoeba histolytica hypothetical protein 0.0066 0.0201 0.126
Echinococcus granulosus importin subunit beta 1 0.0024 0.0043 0.0043
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0056 0.0163 0.1011
Brugia malayi Cadps2 protein 0.0056 0.0163 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0172 0.0172
Echinococcus multilocularis axis inhibition protein axin 0.042 0.1533 0.1533
Schistosoma mansoni growth factor receptor-bound protein 0.0056 0.0163 0.0163
Trichomonas vaginalis hypothetical protein 0.0056 0.0163 0.0921
Schistosoma mansoni hypothetical protein 0.0056 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0201 0.1148
Entamoeba histolytica hypothetical protein 0.042 0.1533 1
Schistosoma mansoni serine/threonine-protein kinase 0.0066 0.0201 0.0201
Mycobacterium tuberculosis Conserved protein 0.003 0.0066 0.0946
Onchocerca volvulus 0.0056 0.0163 0.0841
Echinococcus multilocularis regulator of G protein signaling 7 0.042 0.1533 0.1533
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0163 0.0921
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0056 0.0163 0.0921
Entamoeba histolytica protein kinase, putative 0.0066 0.0201 0.126
Echinococcus granulosus calcium dependent secretion activator 1 0.0056 0.0163 0.0163
Schistosoma mansoni ran 0.0017 0.002 0.002
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0056 0.0163 0.1011
Echinococcus multilocularis Regulator of G protein signaling 20 0.042 0.1533 0.1533

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 3 % Inhibition of IL-6-stimulated STAT3 activation in human THP1 cells at 100 uM incubated for 30 mins prior to IL-6 stimulation measured after 15 mins by EMSA relative to control ChEMBL. 23287056

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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