Detailed information for compound 1857733

Basic information

Technical information
  • TDR Targets ID: 1857733
  • Name: (7E)-7-[(4-hydroxyphenyl)methylidene]-3,4-di( phenyl)-4H-[1,3]thiazolo[2,3-c][1,2,4]triazin -6-one
  • MW: 411.476 | Formula: C24H17N3O2S
  • H donors: 1 H acceptors: 2 LogP: 5.34 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)/C=c\1/sc2=NN=C(C(n2c1=O)c1ccccc1)c1ccccc1
  • InChi: 1S/C24H17N3O2S/c28-19-13-11-16(12-14-19)15-20-23(29)27-22(18-9-5-2-6-10-18)21(25-26-24(27)30-20)17-7-3-1-4-8-17/h1-15,22,28H/b20-15+
  • InChiKey: CTHGCMCEROPAJR-HMMYKYKNSA-N  


Substructure search Similarity search

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Synonyms

  • (7E)-7-[(4-hydroxyphenyl)methylene]-3,4-di(phenyl)-4H-thiazolo[2,3-c][1,2,4]triazin-6-one
  • (7E)-7-(4-hydroxybenzylidene)-3,4-di(phenyl)-4H-thiazolo[2,3-c][1,2,4]triazin-6-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Staphylococcus aureus (strain N315) Probable nicotinate-nucleotide adenylyltransferase Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC Get druggable targets OG5_131883 All targets in OG5_131883
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium berghei nicotinamide/nicotinic acid mononucleotide adenylyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi nicotinamide/nicotinic acid mononucleotide adenylyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein Get druggable targets OG5_131883 All targets in OG5_131883
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii Predicted nucleotidyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva hypothetical protein, conserved Get druggable targets OG5_131883 All targets in OG5_131883
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase Get druggable targets OG5_131883 All targets in OG5_131883
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic Get druggable targets OG5_131883 All targets in OG5_131883
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis cytidylyltransferase family protein Get druggable targets OG5_131883 All targets in OG5_131883
Treponema pallidum hypothetical protein Get druggable targets OG5_131883 All targets in OG5_131883
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Giardia lamblia Nicotinamide-nucleotide adenylyltransferase Probable nicotinate-nucleotide adenylyltransferase   189 aa 153 aa 24.2 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trichomonas vaginalis nicotinamide mononucleotide adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 210 aa 23.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trichomonas vaginalis nicotinamide mononucleotide adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 205 aa 19.0 %
Giardia lamblia Nicotinamide-nucleotide adenylyltransferase Probable nicotinate-nucleotide adenylyltransferase   189 aa 247 aa 20.6 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Trypanosoma cruzi hypothetical protein, conserved Probable nicotinate-nucleotide adenylyltransferase   189 aa 200 aa 20.5 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Plasmodium knowlesi cytoskeleton associated protein, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 170 aa 23.5 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Entamoeba histolytica nicotinamide nucleotide adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 204 aa 24.5 %
Entamoeba histolytica NMN adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 204 aa 24.5 %
Trypanosoma cruzi hypothetical protein, conserved Probable nicotinate-nucleotide adenylyltransferase   189 aa 200 aa 21.0 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Trypanosoma brucei variant surface glycoprotein (VSG, atypical), putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 171 aa 20.5 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0159 0.34
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0024 0.0024
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0187 0.0808
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0024 0.0087
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0345 0.4062 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0547 0.1233
Schistosoma mansoni cpg binding protein 0.0037 0.0321 0.0321
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0073 0.1802
Entamoeba histolytica hypothetical protein 0.0028 0.0219 0.4371
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0159 0.34
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0159 0.0159
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0031 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0024 0.0087
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0297 0.0663
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0159 0.2571
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0159 0.34
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0013 0.0031 0.0077
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0159 0.1733
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0107 0.0107
Trichomonas vaginalis ran, putative 0.0026 0.0187 0.4605
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0187 0.2117
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0406 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0041
Schistosoma mansoni hypothetical protein 0.0019 0.0107 0.0107
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0575 0.1298
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0345 0.4062 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0406 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0299 0.7134
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0013 0.0031 0.0077
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.2266 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0013 0.0031 0.0077
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0766 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0674 0.8741
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0376 0.1642
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0024 0.0087
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.2266 0.5153
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0024 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0024 0.0087
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0013 0.0031 0.0077
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0159 0.34
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0071 0.1054
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5877 0.5877
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0024 0.0087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0041
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0159 0.0391
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0024 0.0041
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0024 0.0041
Schistosoma mansoni hypothetical protein 0.0043 0.0403 0.0403
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0024 0.0087
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0013 0.0031 0.0077
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0766 0.0766
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0013 0.0031 0.0077
Schistosoma mansoni hypothetical protein 0.0019 0.0107 0.0107
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0013 0.0031 0.0077
Brugia malayi steroid hormone receptor 0.0012 0.0024 0.0087
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0107 0.0107
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0013 0.0031 0.0077
Loa Loa (eye worm) hypothetical protein 0.0019 0.0107 0.023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0547 0.0547
Schistosoma mansoni hypothetical protein 0.0041 0.0376 0.0376
Brugia malayi hypothetical protein 0.0043 0.0403 0.1765
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0024 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0024 0.0087
Loa Loa (eye worm) MBCTL1 0.0066 0.0672 0.1519
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0187 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0013 0.0031 0.0077
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0024 0.0024
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0024 0.0024
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0672 0.0672
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0013 0.0031 0.0077
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0013 0.0031 0.0077
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0107 0.0107
Echinococcus multilocularis GPCR, family 2 0.0019 0.0107 0.0107
Brugia malayi CXXC zinc finger family protein 0.0035 0.0297 0.1294
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0159 0.34
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0406 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0024 0.0087
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0024 0.0087
Schistosoma mansoni hypothetical protein 0.0019 0.0107 0.0107
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0035 0.0299 0.0667
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.2266 0.2266
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0769 0.0769
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0024 0.0041
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0013 0.0031 0.0077
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0024 0.0024
Brugia malayi ecdysteroid receptor 0.0012 0.0024 0.0087
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0013 0.0031 0.0077
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0041
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0406 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0013 0.0031 0.0077
Brugia malayi RNA, U transporter 1 0.0099 0.1079 0.475
Loa Loa (eye worm) hypothetical protein 0.0058 0.0575 0.1298
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0013 0.0031 0.0077
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0159 0.34
Schistosoma mansoni coup transcription factor 0.0012 0.0024 0.0024
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0591 0.1334
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0041
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0073 0.1802
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0299 0.0299
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0024 0.0024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0607 0.2665
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.2633 0.2633
Trypanosoma brucei unspecified product 0.0023 0.0159 0.34
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0024 0.0087
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0013 0.0031 0.0077
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0348
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0107 0.023
Echinococcus granulosus dna polymerase eta 0.0023 0.0159 0.0159
Schistosoma mansoni hypothetical protein 0.0494 0.5877 0.5877
Brugia malayi Cytochrome P450 family protein 0.0013 0.0031 0.012
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0219 0.5385
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0024 0.0024
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5877 0.5877
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0672 0.0672
Schistosoma mansoni hypothetical protein 0.0013 0.0031 0.0031
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2266 0.2266
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0406 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0766 0.0766
Leishmania major DNA polymerase eta, putative 0.0023 0.0159 0.1733
Echinococcus granulosus cpg binding protein 0.0037 0.0321 0.0321
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0205 0.2362 0.2362
Entamoeba histolytica hypothetical protein 0.0043 0.0403 0.9923
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0024 0.0087
Treponema pallidum hypothetical protein 0.0345 0.4062 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0006 0.0006
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0299 0.7134
Trypanosoma brucei unspecified product 0.0016 0.0071 0.1054
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0073 0.1115
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0187 0.4153
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0013 0.0031 0.0077
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0159 0.34
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2266 0.2266
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0107 0.0454
Loa Loa (eye worm) hypothetical protein 0.0041 0.0376 0.0843
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0024 0.0024
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0013 0.0031 0.0077
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0406 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0159 0.0159
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0159 0.34
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0006 0.0006
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0766 0.0766
Brugia malayi cytochrome P450 0.0013 0.0031 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0159 0.34
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0041
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0406 1
Echinococcus multilocularis 0.0013 0.0031 0.0031
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0672 0.0672
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0575 0.0575
Echinococcus granulosus dna polymerase kappa 0.0023 0.0159 0.0159
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0159 0.34
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0406 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0159 0.391
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0024 0.0087
Echinococcus granulosus importin subunit beta 1 0.0035 0.0299 0.0299
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0024 0.0024
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0073 0.1802
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0575 0.0575
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0.0031 0.0077
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.0043 0.0403 0.9923
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0159 0.34
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0024 0.0024
Mycobacterium leprae putative cytochrome p450 0.0013 0.0031 0.0077
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0403 0.0403
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0219 0.5385
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0013 0.0031 0.0077
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0024 0.0024
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0073 0.0568
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0547 0.2398
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0066 0.0672 0.1519
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0013 0.0031 0.0077
Echinococcus multilocularis dna polymerase eta 0.0023 0.0159 0.0159
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0406 0.1776
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0345 0.4062 1
Schistosoma mansoni alpha glucosidase 0.0044 0.0406 0.0406
Trypanosoma brucei unspecified product 0.0016 0.0071 0.1054
Echinococcus multilocularis geminin 0.0205 0.2362 0.2362
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0024 0.0024
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0766 0.1887
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0766 1
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0024 0.0024
Echinococcus granulosus snurportin 1 0.0372 0.4392 0.4392
Schistosoma mansoni cytochrome P450 0.0013 0.0031 0.0031
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0406 0.0406
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0672 0.2954
Trypanosoma brucei glucosidase, putative 0.0044 0.0406 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0013 0.0031 0.0077
Brugia malayi nuclear hormone receptor 0.0012 0.0024 0.0087
Mycobacterium leprae Conserved hypothetical protein 0.0013 0.0031 0.0077
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0575 0.0575
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0016 0.0073 0.0153
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0403 0.0403
Schistosoma mansoni cpg binding protein 0.0037 0.0321 0.0321
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0024 0.0024
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0159 0.0683
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0013 0.0031 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0159 0.34
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0345 0.4062 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.0299 0.0288
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0575 0.0575
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0073 0.0304
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0024 0.0087
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0406 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4392 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0219 0.4999
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0159 0.34
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0013 0.0031 0.0077
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0024 0.0041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0024 0.0087
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0024 0.0024
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0013 0.0031 0.0077
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0575 0.0575
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0073 0.1802
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0159 0.0348
Schistosoma mansoni hypothetical protein 0.035 0.413 0.413
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0159 0.0683
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0013 0.0031 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0024 0.0041
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0159 0.34
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0031 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0024 0.0041
Onchocerca volvulus 0.0035 0.0297 0.2213
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0024 0.0024
Onchocerca volvulus 0.0058 0.0575 0.4469
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0013 0.0031 0.0077
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0187 0.4153
Echinococcus granulosus geminin 0.0205 0.2362 0.2362
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0219 0.5385
Brugia malayi mbt repeat family protein 0.0058 0.0575 0.2525
Schistosoma mansoni ran 0.0026 0.0187 0.0187
Echinococcus multilocularis snurportin 1 0.0372 0.4392 0.4392
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0159 0.34
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0013 0.0031 0.0077
Schistosoma mansoni alpha-glucosidase 0.0169 0.1933 0.1933
Leishmania major GTP-binding protein, putative 0.0026 0.0187 0.2117
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0073 0.0399
Brugia malayi nuclear receptor NHR-88 0.0012 0.0024 0.0087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0041
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0406 0.5097
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0607 0.2665
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0024 0.0087
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0372 0.4392 0.4392
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.0043 0.0403 0.9923
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0547 0.0547
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0013 0.0031 0.0077
Brugia malayi Cytochrome P450 family protein 0.0013 0.0031 0.012
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0187 0.0187
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0024 0.0024
Brugia malayi mbt repeat family protein 0.0058 0.0575 0.2525
Echinococcus granulosus GPCR family 2 0.0019 0.0107 0.0107
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.2633 0.2633
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0159 0.0391
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0031 0.0058
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0406 0.0406
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0547 0.0547
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0013 0.0031 0.0077
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0672 0.0672
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0159 0.34
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0575 0.4469
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0013 0.0031 0.0077
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0073 0.1802
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0403 0.0403
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0547 0.0547
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0547 0.0547
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0406 0.0912
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0672 0.0672
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0766 0.0766
Loa Loa (eye worm) hypothetical protein 0.006 0.0607 0.137
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0159 0.34
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0766 0.1887
Echinococcus granulosus cytochrome P450 2K1 0.0013 0.0031 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0406 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0107 0.0454
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.001 0 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0071 0.1054
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0013 0.0031 0.0077
Loa Loa (eye worm) cytochrome P450 0.0013 0.0031 0.0058
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0024 0.0024
Onchocerca volvulus 0.0114 0.1258 1
Leishmania major DNA polymerase kappa, putative 0.0023 0.0159 0.1733
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0024 0.0087
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0013 0.0031 0.0077
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0575 0.0575
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0024 0.0024
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0013 0.0031 0.0077
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0406 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0547 0.0547
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0013 0.0031 0.0077
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0024 0.0024
Schistosoma mansoni cpg binding protein 0.0035 0.0297 0.0297
Schistosoma mansoni importin beta-1 0.0035 0.0299 0.0299
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0073 0.1115
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0607 0.137
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0766 0.1887
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0345 0.4062 1
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0575 0.0575
Entamoeba histolytica hypothetical protein 0.0043 0.0403 0.9923
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0013 0.0031 0.0077
Schistosoma mansoni hypothetical protein 0.0019 0.0107 0.0107
Echinococcus multilocularis cpg binding protein 0.0037 0.0321 0.0321
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0766 0.1887
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0159 0.0159
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0073 0.1115
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0024 0.0024
Plasmodium falciparum importin beta, putative 0.0035 0.0299 0.0288
Leishmania major importin beta-1 subunit, putative 0.0028 0.0219 0.2548
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0071 0.1054
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0073 0.1802
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0013 0.0031 0.0077
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0406 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0024 0.0041
Schistosoma mansoni DNA polymerase eta 0.0023 0.0159 0.0159
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0159 0.0391
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0024 0.0041
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0187 0.4153
Brugia malayi Cytochrome P450 family protein 0.0013 0.0031 0.012
Entamoeba histolytica Ran family GTPase 0.0026 0.0187 0.3419
Brugia malayi Importin beta-1 subunit 0.0035 0.0299 0.1301
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0013 0.0031 0.0077
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0013 0.0031 0.0077
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0013 0.0031 0.0077
Schistosoma mansoni ran 0.0026 0.0187 0.0187
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0159 0.34
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0013 0.0031 0.0077
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0159 0.391
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0159 0.34
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0073 0.1802
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0547 0.0547
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0406 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0024 0.0024
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0041
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0406 0.5097
Brugia malayi Cytochrome P450 family protein 0.0059 0.0591 0.2595
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0073 0.1802
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0024 0.0024
Schistosoma mansoni alpha-glucosidase 0.0169 0.1933 0.1933
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0041
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0299 0.3636
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0187 0.0187
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0187 0.0413
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0159 0.0391
Schistosoma mansoni hypothetical protein 0.0205 0.2362 0.2362

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 1.584893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 3.548133892 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 4.466835922 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
IC50 (functional) 13.7 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 32.1 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay - Set 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.0398 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.5221 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 1 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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