Detailed information for compound 1950144

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 511.499 | Formula: C25H24F3N7O2
  • H donors: 2 H acceptors: 4 LogP: 3.52 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN1CCN(CC1)C(=O)c1[nH]c2c(c1)cc(cc2)Nc1nccc(n1)c1nccc(c1)OCC(F)(F)F
  • InChi: 1S/C25H24F3N7O2/c1-34-8-10-35(11-9-34)23(36)22-13-16-12-17(2-3-19(16)32-22)31-24-30-7-5-20(33-24)21-14-18(4-6-29-21)37-15-25(26,27)28/h2-7,12-14,32H,8-11,15H2,1H3,(H,30,31,33)
  • InChiKey: RVOWBKGMYKZUEJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens spleen tyrosine kinase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tyrosine protein kinase shark Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131855 All targets in OG5_131855
Echinococcus granulosus tyrosine protein kinase shark Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma japonicum ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma japonicum ko:K05855 spleen tyrosine kinase, putative Get druggable targets OG5_131855 All targets in OG5_131855
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major pantothenate kinase subunit, putative 0.0012 0.0021 0.0001
Brugia malayi Bromodomain containing protein 0.0076 0.0898 0.1403
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.003 0.0273 0.0273
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0681 0.5293
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0024
Onchocerca volvulus 0.003 0.0273 0.0744
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0273 0.0253
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0014 0.0044 0.0207
Trypanosoma cruzi metacaspase, putative 0.0032 0.0292 0.2495
Leishmania major importin beta-1 subunit, putative 0.0025 0.0203 0.1614
Loa Loa (eye worm) hypothetical protein 0.0032 0.0292 0.0456
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0273 0.0253
Trichomonas vaginalis esterase, putative 0.0034 0.0329 0.0919
Echinococcus multilocularis synaptojanin 1 0.0012 0.0021 0.0000091458
Loa Loa (eye worm) hypothetical protein 0.0067 0.0781 0.1237
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0261 0.3445 0.5484
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0012 0.0021 0.0000091458
Leishmania major hypothetical protein, conserved 0.0034 0.0329 0.2722
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0121 0.1522 0.1504
Trypanosoma brucei calpain-like protein, putative 0.0014 0.0044 0.0206
Brugia malayi hypothetical protein 0.003 0.0273 0.0403
Echinococcus granulosus tyrosine protein kinase shark 0.0264 0.3493 0.3479
Onchocerca volvulus 0.003 0.0273 0.0744
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0049 0.0049
Entamoeba histolytica recQ family helicase, putative 0.0021 0.015 0.1526
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.015 0.013
Echinococcus multilocularis fmrfamide receptor 0.003 0.0273 0.0253
Giardia lamblia Hypothetical protein 0.0012 0.0023 0.0039
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0012 0.0021 0.0000091458
Echinococcus multilocularis tyrosine protein kinase shark 0.0264 0.3493 0.3479
Loa Loa (eye worm) hypothetical protein 0.0034 0.0329 0.0515
Onchocerca volvulus Neuropeptide F receptor homolog 0.003 0.0273 0.0744
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0331 0.3359
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0485 0.41
Brugia malayi AKH receptor 0.003 0.0273 0.0403
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0292 0.0811
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0019 0.0114 0.0824
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.003 0.0273 0.0253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0021 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0329 0.2817
Mycobacterium tuberculosis Probable esterase LipL 0.0034 0.0329 0.1078
Schistosoma mansoni hypothetical protein 0.0737 1 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.015 0.1145
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0273 0.0253
Brugia malayi MH2 domain containing protein 0.0107 0.1323 0.2081
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.003 0.0273 0.0253
Brugia malayi hypothetical protein 0.003 0.0273 0.0403
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0094 0.1152 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0171 0.1331
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0092 0.0072
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0012 0.0021 0.0024
Schistosoma mansoni hypothetical protein 0.0023 0.0179 0.0179
Echinococcus multilocularis sex peptide receptor 0.003 0.0273 0.0253
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0273 0.0426
Mycobacterium ulcerans leucyl aminopeptidase 0.0094 0.1152 1
Echinococcus granulosus orexin receptor type 2 0.003 0.0273 0.0253
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.003 0.0273 0.0403
Trypanosoma brucei flagellum-adhesion glycoprotein, putative 0.0012 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0021 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0021 0.0011
Schistosoma mansoni hypothetical protein 0.003 0.0272 0.0272
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0021 0.0021
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0681 0.0681
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0021 0.0161
Onchocerca volvulus Cell death protein 3 homolog 0.0061 0.0698 0.2
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0082 0.0985 0.1541
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0082 0.0985 0.1541
Schistosoma mansoni neutral sphingomyelinase 0.0012 0.0021 0.0021
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0284 0.233
Schistosoma mansoni biogenic amine receptor 0.003 0.0273 0.0273
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0021 0.0011
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0122 0.1535 0.2421
Schistosoma mansoni hypothetical protein 0.0167 0.2158 0.2158
Echinococcus multilocularis serotonin receptor 0.003 0.0273 0.0253
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0273 0.0273
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0331 0.2572
Trichomonas vaginalis ran, putative 0.0023 0.0171 0.0455
Schistosoma mansoni hypothetical protein 0.003 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0012 0.0021 0.0001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0024
Echinococcus granulosus tachykinin peptides receptor 99D 0.003 0.0273 0.0253
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.003 0.0273 0.0253
Loa Loa (eye worm) NCL-1 protein 0.0012 0.0023 0.0028
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0273 0.0253
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0014 0.0044 0.0334
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0034 0.0329 0.0515
Mycobacterium tuberculosis Conserved protein 0.0034 0.0329 0.1078
Echinococcus granulosus apoptotic protease activating factor 1 0.003 0.0262 0.0242
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0273 0.0253
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0032 0.0104
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0019 0.0114 0.0173
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0024
Brugia malayi hypothetical protein 0.003 0.0273 0.0403
Schistosoma mansoni biogenic amine receptor 0.003 0.0273 0.0273
Brugia malayi G protein-coupled receptor 0.003 0.0273 0.0403
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0019 0.0114 0.0824
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0021 0.0011
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.003 0.0273 0.0273
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0014 0.0044 0.0334
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0049 0.0028
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.003 0.0273 0.0403
Echinococcus granulosus neutral sphingomyelinase 0.0012 0.0021 0.0000091458
Schistosoma mansoni cript-related 0.0012 0.0021 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0292 0.0811
Brugia malayi G-protein coupled receptor 0.003 0.0273 0.0403
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0331 0.0925
Brugia malayi Dopamine receptor protein 1 0.003 0.0273 0.0403
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0036 0.0355 0.0355
Echinococcus granulosus fmrfamide receptor 0.003 0.0273 0.0253
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0028
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.00000000019385
Trypanosoma cruzi mitochondrial protein 99, putative 0.0012 0.0021 0.0131
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0331 0.0311
Schistosoma mansoni hypothetical protein 0.0012 0.0023 0.0023
Echinococcus granulosus tm gpcr rhodopsin 0.0397 0.5327 0.5318
Schistosoma mansoni opsin-like receptor 0.003 0.0273 0.0273
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0014 0.0044 0.0334
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0034 0.0329 0.0493
Trypanosoma brucei metacaspase MCA3 0.0032 0.0292 0.2396
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0021 0.0131
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.015 0.0231
Mycobacterium tuberculosis Possible penicillin-binding protein 0.022 0.2879 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.015 0.013
Trypanosoma cruzi ISWI complex protein 0.003 0.0272 0.2322
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0019 0.0114 0.0173
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0674 1
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS17 0.0012 0.0023 0.0009
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0021 0.0024
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Schistosoma mansoni alpha-1 adrenergic receptor 0.003 0.0273 0.0273
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0331 0.0925
Echinococcus multilocularis beta LACTamase domain containing family member 0.0034 0.0329 0.0309
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0021 0.0011
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0034 0.0329 0.1078
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0014 0.0044 0.0334
Schistosoma mansoni hypothetical protein 0.0041 0.0417 0.0417
Schistosoma mansoni brat protein 0.0012 0.0023 0.0023
Brugia malayi Serotonin/octopamine receptor family protein 7 0.003 0.0273 0.0403
Onchocerca volvulus 0.0034 0.0329 0.0909
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0021 0.0131
Schistosoma mansoni caspase-7 (C14 family) 0.0061 0.0698 0.0698
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0012 0.0021 0.0024
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.0329 0.0919
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0273 0.0273
Schistosoma mansoni peptidylglycine monooxygenase 0.0248 0.3266 0.3266
Echinococcus granulosus 7TM GPCR rhodopsin 0.003 0.0273 0.0253
Echinococcus multilocularis g-protein coupled receptor 0.003 0.0273 0.0253
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0331 0.0925
Trypanosoma brucei antigen, putative 0.0014 0.0044 0.0206
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0273 0.0253
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0674 0.1937
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0292 0.0811
Echinococcus multilocularis brain tumor protein 0.0012 0.0023 0.0003
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0012 0.0021 0.0131
Brugia malayi Tachykinin-like peptides receptor 99D 0.003 0.0273 0.0403
Echinococcus multilocularis dnaJ subfamily B 0.0737 1 1
Schistosoma mansoni calpain C (C02 family) 0.0014 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.003 0.0262 0.0408
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0485 0.4178
Echinococcus multilocularis somatostatin receptor 0.003 0.0273 0.0253
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.015 0.1145
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0012 0.0021 0.0131
Brugia malayi RNA, U transporter 1 0.0089 0.1075 0.1686
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0021 0.021
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0273 0.0253
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0111 0.1383 0.1383
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0021 0.0000091458
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0171 0.133
Brugia malayi neuropeptide F receptor 0.003 0.0273 0.0403
Brugia malayi hypothetical protein 0.003 0.0273 0.0403
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0019 0.0114 0.0824
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0681 0.5831
Leishmania major cathepsin L-like protease 0.0046 0.0485 0.4101
Plasmodium falciparum metacaspase-like protein 0.0032 0.0292 0.2396
Schistosoma mansoni biogenic amine receptor 0.003 0.0273 0.0273
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0021 0.0131
Loa Loa (eye worm) hypothetical protein 0.0034 0.0329 0.0515
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0336 0.0527
Schistosoma mansoni alpha-glucosidase 0.0134 0.1699 0.1699
Trypanosoma cruzi metacaspase, putative 0.0032 0.0292 0.2495
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0674 0.5773
Echinococcus multilocularis serotonin receptor 0.003 0.0273 0.0253
Echinococcus granulosus histone lysine methyltransferase setb 0.0067 0.0781 0.0762
Brugia malayi Bromodomain containing protein 0.0151 0.1938 0.3065
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0284 0.0264
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0021 0.0161
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Brugia malayi follicle stimulating hormone receptor 0.0261 0.3445 0.5473
Loa Loa (eye worm) RING finger protein nhl-1 0.0012 0.0023 0.0028
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0397 0.5327 0.5318
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0082 0.0985 0.8516
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.015 0.0207
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0082 0.0985 0.8536
Trypanosoma brucei ISWI complex protein 0.003 0.0272 0.222
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0021 0.0024
Echinococcus granulosus caspase 0.0084 0.1009 0.0991
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.051 0.049
Schistosoma mansoni alpha-glucosidase 0.0134 0.1699 0.1699
Plasmodium falciparum M17 leucyl aminopeptidase 0.0094 0.1152 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0021 0.0011
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0292 0.0811
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0576 0.4999
Trypanosoma cruzi mitochondrial protein 99, putative 0.0012 0.0021 0.0131
Loa Loa (eye worm) beta-lactamase 0.0034 0.0329 0.0515
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0091 0.0247
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0331 0.0925
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0094 0.1152 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0021 0.0011
Loa Loa (eye worm) fibroinase 0.0012 0.0021 0.0024
Mycobacterium tuberculosis Probable hydrolase 0.0034 0.0329 0.1078
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0576 0.4908
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0021 0.0011
Onchocerca volvulus 0.003 0.0273 0.0744
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0485 0.41
Brugia malayi G-protein coupled receptor 0.003 0.0273 0.0403
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0021 0.0021
Echinococcus multilocularis caspase 2 0.0061 0.0698 0.0679
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0674 0.5773
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0012 0.0021 0.0131
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0091 0.0625
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0292 0.0811
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0032 0.0046
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0171 0.0151
Loa Loa (eye worm) hypothetical protein 0.0061 0.0698 0.1104
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0292 0.0811
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0091 0.0748
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.003 0.0273 0.0273
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0834 0.0815
Echinococcus granulosus g protein coupled receptor 0.003 0.0273 0.0253
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0329 0.0919
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0171 0.0264
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0014 0.0044 0.0334
Echinococcus multilocularis caspase 0.0084 0.1009 0.0991
Echinococcus granulosus calpain 7 C02 family 0.0014 0.0044 0.0023
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.051 0.049
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0021 0.0011
Trypanosoma brucei metacaspase MCA2 0.0032 0.0292 0.2396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0485 0.41
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0014 0.0044 0.0334
Schistosoma mansoni hypothetical protein 0.003 0.0273 0.0273
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0485 0.41
Loa Loa (eye worm) CXXC zinc finger family protein 0.0052 0.0568 0.0896
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0017 0.00000000035835
Loa Loa (eye worm) hypothetical protein 0.0034 0.0329 0.0515
Mycobacterium tuberculosis Probable lipase LipD 0.0034 0.0329 0.1078
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.015 0.1145
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0038 0.0378 0.0358
Echinococcus granulosus g protein coupled receptor 0.003 0.0273 0.0253
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0292 0.227
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0681 0.4271
Echinococcus granulosus calpain 0.0014 0.0044 0.0023
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0049 0.0028
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0126 0.1586 0.2502
Schistosoma mansoni caspase-3 (C14 family) 0.0084 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0485 0.41
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0019 0.0114 0.0094
Echinococcus granulosus cpg binding protein 0.0058 0.066 0.0641
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0082 0.0985 0.2852
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0292 0.0811
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0681 0.4271
Brugia malayi Hypothetical RING finger protein F54G8.4 in chromosome III 0.0012 0.0023 0.0004
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0021 0.0131
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.032 0.032
Onchocerca volvulus 0.009 0.1094 0.3168
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0021 0.0131
Onchocerca volvulus 0.003 0.0273 0.0744
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0021 0.021
Schistosoma mansoni hypothetical protein 0.0333 0.4434 0.4434
Onchocerca volvulus 0.003 0.0273 0.0744
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.032 0.03
Schistosoma mansoni caspase-7 (C14 family) 0.0084 0.1009 0.1009
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0248 0.3266 0.5187
Echinococcus multilocularis deoxyribonuclease 1 2 0.0012 0.0021 0.0000091458
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0292 0.0811
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0021 0.018
Toxoplasma gondii leucyl aminopeptidase LAP 0.0094 0.1152 0.8963
Schistosoma mansoni opsin-like receptor 0.003 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0032 0.0299 0.0467
Echinococcus multilocularis brain tumor protein 0.0012 0.0023 0.0003
Leishmania major hypothetical protein, conserved 0.0052 0.0576 0.4908
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0273 0.0273
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.051 0.051
Schistosoma mansoni hypothetical protein 0.0012 0.0023 0.0023
Brugia malayi Serotonin receptor 0.003 0.0273 0.0403
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0273 0.0253
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0019 0.0114 0.0149
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.003 0.0273 0.0253
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS18 0.0012 0.0023 0.0009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Echinococcus granulosus caspase 3 0.0052 0.0573 0.0553
Schistosoma mansoni neuropeptide receptor 0.003 0.0273 0.0273
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0021 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.1268 0.1268
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0674 0.0655
Leishmania major hypothetical protein, conserved 0.0012 0.0021 0.0001
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0094 0.1152 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0021 0.0011
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0273 0.0273
Echinococcus multilocularis calpain 7 (C02 family) 0.0014 0.0044 0.0023
Echinococcus granulosus brain tumor protein 0.0012 0.0023 0.0003
Loa Loa (eye worm) cysteine protease 0.0012 0.0021 0.0024
Brugia malayi ORL1-like opioid receptor 0.003 0.0273 0.0403
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0091 0.0793
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0032 0.0046
Echinococcus multilocularis snurportin 1 0.0333 0.4434 0.4423
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0021 0.0161
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.015 0.013
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0674 0.5828
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0012 0.0021 0.0011
Schistosoma mansoni amine GPCR 0.003 0.0273 0.0273
Loa Loa (eye worm) melatonin receptor type 1A 0.003 0.0273 0.0426
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.003 0.0273 0.0426
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0273 0.0253
Entamoeba histolytica hypothetical protein 0.0012 0.0023 0.0236
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0273 0.0426
Schistosoma mansoni DNA helicase recq1 0.0021 0.015 0.015
Brugia malayi beta-lactamase 0.0034 0.0329 0.0493
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0049 0.0028
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0091 0.0137
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Brugia malayi hypothetical protein 0.003 0.0273 0.0403
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.0329 0.0919
Plasmodium vivax vivapain-2 0.0012 0.0021 0.0179
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0084 0.1009 0.0991
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0466 0.6277 0.6277
Onchocerca volvulus 0.003 0.0273 0.0744
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0203 0.1723
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0012 0.0021 0.0011
Onchocerca volvulus 0.003 0.0273 0.0744
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0292 0.0811
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.003 0.0273 0.0403
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Giardia lamblia Haloacid dehalogenase-like hydrolase family 0.0012 0.0023 0.0039
Brugia malayi B-box zinc finger family protein 0.0012 0.0023 0.0004
Schistosoma mansoni carbon catabolite repressor protein 0.0012 0.0021 0.0021
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0273 0.0273
Brugia malayi hypothetical protein 0.003 0.0273 0.0403
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0273 0.0253
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.1268 0.125
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0273 0.0253
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0082 0.0985 0.8516
Trypanosoma brucei metacaspase 0.0032 0.0292 0.2396
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0317 0.0297
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0006 0.005
Schistosoma mansoni dopamine-beta-monooxygenase 0.0248 0.3266 0.3266
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0781 0.0781
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0094 0.1152 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0485 0.41
Loa Loa (eye worm) hypothetical protein 0.0248 0.3266 0.5199
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0019 0.0114 0.0944
Leishmania major hypothetical protein, conserved 0.003 0.0272 0.2221
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0014 0.0044 0.0334
Schistosoma mansoni peptide (allatostatin)-like receptor 0.003 0.0273 0.0273
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.015 0.0393
Echinococcus granulosus lysosomal alpha glucosidase 0.0156 0.1997 0.1981
Onchocerca volvulus 0.003 0.0273 0.0744
Echinococcus multilocularis leucyl aminopeptidase 0.0019 0.0114 0.0094
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0273 0.0253
Schistosoma mansoni hypothetical protein 0.0012 0.0023 0.0023
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0021 0.0161
Brugia malayi Cell death protein 3 precursor 0.0061 0.0698 0.1083
Echinococcus granulosus importin subunit beta 1 0.0031 0.0284 0.0264
Echinococcus granulosus thyrotropin releasing hormone receptor 0.003 0.0273 0.0253
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.1268 0.125
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0171 0.1485
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Schistosoma mansoni histamine h1 receptor 0.003 0.0273 0.0273
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0032 0.0105
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0079 0.0116
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0674 0.5849
Schistosoma mansoni hypothetical protein 0.003 0.0262 0.0262
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0466 0.6277 1
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0021 0.0209
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0012 0.0021 0.0024
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0466 0.6277 0.6269
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0331 0.3359
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Echinococcus granulosus calpain A 0.0038 0.0378 0.0358
Brugia malayi RE15519p 0.003 0.0273 0.0403
Schistosoma mansoni importin beta-1 0.0031 0.0284 0.0284
Echinococcus multilocularis neutral sphingomyelinase 0.0012 0.0021 0.0000091458
Loa Loa (eye worm) hypothetical protein 0.0027 0.0223 0.0347
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0331 0.0925
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0674 0.1937
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0014 0.0044 0.0206
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0021 0.0161
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0082 0.0985 0.1561
Echinococcus multilocularis neuropeptide FF receptor 2 0.003 0.0273 0.0253
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0273 0.0253
Schistosoma mansoni alpha glucosidase 0.0035 0.0331 0.0331
Brugia malayi PHD-finger family protein 0.0052 0.0574 0.0885
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Trichomonas vaginalis Phospholipase C precursor, putative 0.0012 0.0021 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0273 0.0253
Schistosoma mansoni hypothetical protein 0.0167 0.2158 0.2158
Onchocerca volvulus 0.0034 0.0317 0.0874
Echinococcus granulosus allatostatin A receptor 0.003 0.0273 0.0253
Trypanosoma brucei calpain-like protein, putative 0.0014 0.0044 0.0206
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0032 0.0233
Toxoplasma gondii histone lysine methyltransferase SET1 0.0104 0.1286 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0032 0.0046
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0032 0.0046
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0171 0.1443
Schistosoma mansoni myosin xvIII 0.003 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0091 0.0748
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0012 0.0021 0.0131
Brugia malayi Pre-SET motif family protein 0.0227 0.298 0.473
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0021 0.021
Echinococcus multilocularis leucine aminopeptidase protein 0.0094 0.1152 0.1134
Plasmodium vivax calpain, putative 0.0014 0.0044 0.0382
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0317 0.2465
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0179 0.0158
Echinococcus multilocularis caspase 8 0.0032 0.0292 0.0272
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0028
Leishmania major endonuclease/exonuclease protein-like protein 0.0012 0.0021 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0273 0.0253
Brugia malayi hypothetical protein 0.003 0.0273 0.0403
Echinococcus multilocularis cpg binding protein 0.0058 0.066 0.0641
Schistosoma mansoni ran 0.0023 0.0171 0.0171
Schistosoma mansoni ran 0.0023 0.0171 0.0171
Brugia malayi hypothetical protein 0.003 0.0273 0.0403
Echinococcus multilocularis bloom syndrome protein 0.0021 0.015 0.013
Echinococcus multilocularis calpain 5 0.0014 0.0044 0.0023
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0012 0.0021 0.0131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0021 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0273 0.0273
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0032 0.0019
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0273 0.0273
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0273 0.0273
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0331 0.2834
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0091 0.0071
Schistosoma mansoni tyrosine kinase 0.0264 0.3493 0.3493
Schistosoma mansoni amine GPCR 0.003 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0091 0.0625
Toxoplasma gondii exonuclease III APE 0.0059 0.0674 0.5243
Trypanosoma brucei aminopeptidase, putative 0.0019 0.0114 0.0824
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0019 0.0114 0.0944
Schistosoma mansoni neuropeptide receptor 0.003 0.0273 0.0273
Echinococcus granulosus serotonin receptor 0.003 0.0273 0.0253
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0012 0.0021 0.0001
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0094 0.1152 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0576 0.4974
Brugia malayi isocitrate dehydrogenase 0.0017 0.0091 0.0113
Schistosoma mansoni zinc finger protein 0.0042 0.0429 0.0429
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.1268 0.125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.1268 0.1268
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0019 0.0114 0.0824
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0273 0.0253
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0032 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0012 0.0021 0.0011
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0171 0.0241
Schistosoma mansoni calpain-7 (C02 family) 0.0017 0.0083 0.0083
Echinococcus granulosus caspase 2 0.0061 0.0698 0.0679
Loa Loa (eye worm) hypothetical protein 0.0076 0.09 0.1426
Trypanosoma brucei calpain-like protein, putative 0.0014 0.0044 0.0206
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0171 0.0151
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0674 0.1066
Loa Loa (eye worm) B-box zinc finger family protein 0.0012 0.0023 0.0028
Brugia malayi neuropeptide F receptor 0.003 0.0273 0.0403
Plasmodium falciparum metacaspase 1 0.0032 0.0292 0.2396
Trypanosoma brucei flagellum-adhesion glycoprotein, putative 0.0012 0.0023 0.0023
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0012 0.0021 0.0000091458
Echinococcus multilocularis G-protein coupled receptor, putative 0.003 0.0273 0.0253
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0273 0.0273
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.003 0.0273 0.0273
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0082 0.0985 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0331 0.0925
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0292 0.0811
Schistosoma mansoni growth hormone secretagogue receptor 0.003 0.0273 0.0273
Echinococcus granulosus alpha 1A adrenergic receptor 0.003 0.0273 0.0253
Loa Loa (eye worm) hypothetical protein 0.0466 0.6277 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0019 0.0114 0.0824
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0091 0.0626
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0257
Entamoeba histolytica Ran family GTPase 0.0023 0.0171 0.1738
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0485 0.41
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0292 0.0811
Brugia malayi Dopamine receptor 0.003 0.0273 0.0403
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0094 0.1152 1
Trypanosoma cruzi metacaspase, putative 0.0032 0.0292 0.2495
Brugia malayi gonadotropin-releasing hormone receptor 2 0.003 0.0273 0.0403
Echinococcus granulosus tripartite motif containing protein 3 0.0012 0.0023 0.0003
Schistosoma mansoni hypothetical protein 0.0012 0.0023 0.0023
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0091 0.0071
Echinococcus granulosus leucyl aminopeptidase 0.0019 0.0114 0.0094
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0171 0.1329
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0038 0.0378 0.0358
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0042 0.043 0.3701
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0091 0.0711
Brugia malayi calpain family protein 1 0.0036 0.0355 0.0535
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0082 0.0985 0.2852
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0273 0.0253
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0021 0.0161
Echinococcus multilocularis neuropeptide receptor 0.003 0.0273 0.0253
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0285 0.0265
Echinococcus multilocularis biogenic amine (5HT) receptor 0.003 0.0273 0.0253
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Loa Loa (eye worm) TYRA-2 protein 0.003 0.0273 0.0426
Echinococcus multilocularis tripartite motif containing protein 3 0.0012 0.0023 0.0003
Echinococcus granulosus calpain A 0.0014 0.0044 0.0023
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0273 0.0273
Echinococcus multilocularis calpain family protein 1, d 0.0027 0.0223 0.0203
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0014 0.0044 0.0334
Schistosoma mansoni cpg binding protein 0.0058 0.066 0.066
Schistosoma mansoni amine GPCR 0.003 0.0273 0.0273
Echinococcus multilocularis g protein coupled receptor 0.003 0.0273 0.0253
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0284 0.2212
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0012 0.0021 0.0011
Echinococcus granulosus snurportin 1 0.0333 0.4434 0.4423
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0094 0.1152 0.3959
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0032 0.0292 0.0292
Trypanosoma brucei glucosidase, putative 0.0035 0.0331 0.2739
Loa Loa (eye worm) transcription factor SMAD2 0.0107 0.1323 0.21
Echinococcus granulosus beta LACTamase domain containing family member 0.0034 0.0329 0.0309
Brugia malayi Glycosyl hydrolases family 31 protein 0.0156 0.1997 0.3159
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0034 0.0329 0.1078
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0012 0.0021 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.1268 0.125
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0156 0.1997 0.3176
Loa Loa (eye worm) calpain family protein 1 0.0036 0.0355 0.0558
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0466 0.6277 0.6269
Schistosoma mansoni calpain (C02 family) 0.0014 0.0044 0.0044
Brugia malayi beta-lactamase family protein 0.0034 0.0329 0.0493
Leishmania major GTP-binding protein, putative 0.0023 0.0171 0.133
Brugia malayi larval opioid receptor 0.003 0.0273 0.0403
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0273 0.0273
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0273 0.0426
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0021 0.0000091458
Brugia malayi sulfakinin receptor protein 0.003 0.0273 0.0403
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0273 0.0273
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0082 0.0985 0.8543
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0082 0.0985 0.0985
Echinococcus multilocularis g protein coupled receptor 0.003 0.0273 0.0253
Entamoeba histolytica hypothetical protein 0.0025 0.0203 0.2065
Brugia malayi B-box type zinc-finger protein ncl-1 0.0012 0.0023 0.0004
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0292 0.2532
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0017 0.00000000035835
Echinococcus granulosus G protein coupled receptor 139 0.003 0.0273 0.0253
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0331 0.0925
Echinococcus granulosus dro:myosuppressin receptor 0.003 0.0273 0.0253
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0273 0.0273
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0082 0.0985 0.0966
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.015 0.0207
Schistosoma mansoni bromodomain containing protein 0.0128 0.1619 0.1619
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0012 0.0021 0.0001
Trypanosoma brucei calpain-like protein, putative 0.0014 0.0044 0.0206
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0019 0.0114 0.0114
Mycobacterium tuberculosis Conserved protein 0.0034 0.0329 0.1078
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0012 0.0021 0.0001
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.003 0.0273 0.0426
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0021 0.0011
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0674 0.1044
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0292 0.0811
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0273 0.0273
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0006 0.0044
Schistosoma mansoni adenoreceptor 0.003 0.0273 0.0273
Echinococcus granulosus peptide allatostatin:somatostatin 0.003 0.0273 0.0253
Brugia malayi G protein-coupled receptor F59B2.13 0.003 0.0273 0.0403
Echinococcus granulosus neuropeptide receptor 0.003 0.0273 0.0253
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0417 0.0656
Trypanosoma brucei Metacaspase-4 0.0032 0.0292 0.2396
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.015 0.1169
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.015 0.1169
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0028
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0024
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0292 0.227
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0067 0.0781 0.0762
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0017 0.00000000035835
Leishmania major hypothetical protein, conserved 0.0012 0.0021 0.0001
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0032 0.033
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0034 0.0329 0.0515
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0674 0.5773
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0834 0.0815
Brugia malayi putative neuropeptide receptor 0.003 0.0273 0.0403
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0014 0.0044 0.0207
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0674 0.4192
Schistosoma mansoni DNA helicase recq5 0.0021 0.015 0.015
Mycobacterium tuberculosis Conserved protein 0.0034 0.0329 0.1078
Plasmodium vivax SET domain protein, putative 0.0034 0.0317 0.275
Trypanosoma cruzi major cysteine proteinase, putative 0.0036 0.035 0.3003
Echinococcus granulosus sex peptide receptor 0.003 0.0273 0.0253
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0331 0.0925
Onchocerca volvulus 0.0052 0.0568 0.1615
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0273 0.0253
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0021 0.0011
Loa Loa (eye worm) MH2 domain-containing protein 0.0107 0.1323 0.21
Echinococcus multilocularis zinc finger protein 0.0042 0.0429 0.0409
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0021 0.0024
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0681 0.2308
Brugia malayi Melatonin receptor type 1A 0.003 0.0273 0.0403
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0674 0.0655
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0021 0.0011
Echinococcus multilocularis neuropeptide receptor 0.003 0.0273 0.0253
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0021 0.018
Brugia malayi calpain 7 0.0014 0.0044 0.0037
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0171 0.2302
Echinococcus granulosus g-protein coupled receptor 0.003 0.0273 0.0253
Schistosoma mansoni neuropeptide receptor 0.003 0.0273 0.0273
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0331 0.274
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0485 0.4178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0485 0.41
Schistosoma mansoni leucine aminopeptidase 0.0019 0.0114 0.0114
Loa Loa (eye worm) B-box zinc finger family protein 0.0012 0.0023 0.0028
Brugia malayi Importin beta-1 subunit 0.0031 0.0284 0.0422
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0273 0.0253
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0273 0.0253
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Onchocerca volvulus 0.0258 0.3409 1
Brugia malayi hypothetical protein 0.003 0.0273 0.0403
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0021 0.021
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Echinococcus multilocularis neuropeptide s receptor 0.003 0.0273 0.0253
Brugia malayi Serotonin receptor 0.003 0.0273 0.0403
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0038 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.003 0.0273 0.0273
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0485 0.41
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0082 0.0985 0.7657
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0021 0.0011
Schistosoma mansoni synaptojanin 0.0012 0.0021 0.0021
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.015 0.013
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0091 0.0113
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.015 0.1261
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0674 0.2286
Echinococcus granulosus leucine aminopeptidase protein 0.0094 0.1152 0.1134
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0329 0.0329
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0082 0.0985 0.8536
Echinococcus multilocularis calpain 0.0014 0.0044 0.0023
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0329 0.2853
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0331 0.0496
Plasmodium vivax importin-beta 2, putative 0.0031 0.0284 0.2468
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0329 0.0919
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0019 0.0114 0.0149
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0203 0.055
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0485 0.4178
Onchocerca volvulus 0.003 0.0273 0.0744
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0485 0.41
Onchocerca volvulus 0.003 0.0273 0.0744
Schistosoma mansoni tyrosine kinase 0.0258 0.3409 0.3409
Echinococcus granulosus synaptojanin 1 0.0012 0.0021 0.0000091458
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0273 0.0273
Plasmodium vivax exodeoxyribonuclease III, putative 0.0012 0.0021 0.018
Leishmania major cathepsin L-like protease 0.0046 0.0485 0.4101
Brugia malayi hypothetical protein 0.003 0.0262 0.0386
Treponema pallidum hypothetical protein 0.0012 0.0021 0.0224
Echinococcus multilocularis hypothetical protein 0.0014 0.0044 0.0023
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0017 0.00000000035835
Brugia malayi beta-lactamase family protein 0.0034 0.0329 0.0493
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Brugia malayi hypothetical protein 0.003 0.0273 0.0403
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0012 0.0021 0.0011
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0021 0.0161
Plasmodium vivax vivapain-2 0.0012 0.0021 0.0179
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0032 0.0046
Echinococcus granulosus calpain 5 0.0014 0.0044 0.0023
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.003 0.0273 0.0253
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.003 0.0273 0.0253
Echinococcus multilocularis allatostatin A receptor 0.003 0.0273 0.0253
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0329 0.0919
Trypanosoma cruzi cruzipain precursor, putative 0.0046 0.0485 0.4178
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0017 0.00000000035835
Echinococcus multilocularis neuropeptide receptor A26 0.003 0.0273 0.0253
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0284 0.233
Loa Loa (eye worm) hypothetical protein 0.0034 0.0329 0.0515
Echinococcus multilocularis calpain A 0.0038 0.0378 0.0358
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0576 0.4908
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0032 0.0046
Onchocerca volvulus 0.003 0.0273 0.0744
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0273 0.0253
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.003 0.0273 0.0744
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Schistosoma mansoni hypothetical protein 0.003 0.0273 0.0273
Schistosoma mansoni nocturnin 0.0012 0.0021 0.0021
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0012 0.0021 0.021
Schistosoma mansoni zinc finger protein 0.003 0.0272 0.0272
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0032 0.0233
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0273 0.0253
Brugia malayi cytosol aminopeptidase 0.0019 0.0114 0.0149
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0021 0.021
Echinococcus granulosus hypothetical protein 0.003 0.0273 0.0253
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0012 0.0021 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0021 0.0011
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0292 0.0811
Echinococcus multilocularis dro:myosuppressin receptor 0.003 0.0273 0.0253
Echinococcus multilocularis orexin receptor type 2 0.003 0.0273 0.0253
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0091 0.0071
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0012 0.0021 0.021
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0292 0.2495
Toxoplasma gondii ABC1 family protein 0.0034 0.0329 0.2557
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0292 0.2495
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0292 0.0811
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0082 0.0985 0.8516
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Schistosoma mansoni amine GPCR 0.003 0.0273 0.0273
Brugia malayi B-box type zinc-finger protein ncl-1 0.0012 0.0023 0.0004
Trypanosoma brucei hypothetical protein, conserved 0.0034 0.0329 0.2722
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0103 0.1268 0.2013
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Plasmodium vivax metacaspase 1, putative 0.0032 0.0292 0.2532
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0091 0.0711
Loa Loa (eye worm) hypothetical protein 0.0087 0.1057 0.1677
Echinococcus multilocularis leucyl aminopeptidase 0.0019 0.0114 0.0094
Echinococcus multilocularis lysosomal alpha glucosidase 0.0156 0.1997 0.1981
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.1268 0.1268
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0681 0.0661
Echinococcus multilocularis g protein coupled receptor 0.003 0.0273 0.0253
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0032 0.0035
Loa Loa (eye worm) RecQ helicase 0.0021 0.015 0.0231
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.003 0.0273 0.0426
Brugia malayi Pre-SET motif family protein 0.0034 0.0317 0.0474
Trypanosoma cruzi cysteine peptidase, putative 0.0012 0.0021 0.013
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0674 0.5828
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0681 0.0661
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0331 0.2834
Echinococcus granulosus neuropeptide receptor 0.003 0.0273 0.0253
Echinococcus multilocularis lysosomal alpha glucosidase 0.0156 0.1997 0.1981
Loa Loa (eye worm) hypothetical protein 0.0081 0.0965 0.1529
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0021 0.021
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0021 0.0024
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0082 0.0985 0.0966
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0038 0.0378 0.0378
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0014 0.0044 0.0334
Plasmodium falciparum importin beta, putative 0.0031 0.0284 0.233
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.015 0.0393
Echinococcus granulosus traf and tnf receptor associated protein 0.0012 0.0021 0.0000091458
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0091 0.0071
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0681 0.0681
Echinococcus multilocularis alpha 1A adrenergic receptor 0.003 0.0273 0.0253
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0273 0.0273
Onchocerca volvulus 0.003 0.0273 0.0744
Loa Loa (eye worm) hypothetical protein 0.0052 0.0576 0.091
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0032 0.0292 0.0433
Schistosoma mansoni cpg binding protein 0.0052 0.0568 0.0568
Trypanosoma cruzi ISWI complex protein 0.003 0.0272 0.2322
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0171 0.1443
Echinococcus granulosus geminin 0.0167 0.2158 0.2142
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0092 0.0138
Echinococcus multilocularis traf and tnf receptor associated protein 0.0012 0.0021 0.0000091458
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0021 0.0011
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0012 0.0021 0.021
Onchocerca volvulus 0.0023 0.0167 0.0431
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0012 0.0021 0.0000091458
Echinococcus multilocularis tachykinin peptides receptor 99D 0.003 0.0273 0.0253
Plasmodium falciparum DNase I-like protein, putative 0.0012 0.0021 0.0001
Onchocerca volvulus 0.003 0.0273 0.0744
Echinococcus multilocularis leucyl aminopeptidase 0.0019 0.0114 0.0094
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.0231
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0014 0.0044 0.0207
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0292 0.227
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0273 0.0253
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.003 0.0273 0.0253
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0273 0.0253
Brugia malayi B-box zinc finger family protein 0.0012 0.0023 0.0004
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0179 0.0158
Brugia malayi Cytochrome P450 family protein 0.0016 0.0079 0.0093
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0021 0.018
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0082 0.0985 0.1561
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0273 0.0253
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0331 0.0518
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0021 0.0011
Loa Loa (eye worm) hypothetical protein 0.0031 0.0284 0.0444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0021 0.0011
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.032 0.032
Echinococcus granulosus neuropeptide s receptor 0.003 0.0273 0.0253
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0292 0.0811
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.015 0.1145
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0017 0.00000000035835
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0021 0.0011
Echinococcus multilocularis geminin 0.0167 0.2158 0.2142
Echinococcus multilocularis fmrfamide receptor 0.003 0.0273 0.0253
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0014 0.0044 0.0334
Brugia malayi hypothetical protein 0.0052 0.0576 0.0888
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0576 0.4974
Schistosoma mansoni Mername-AA248 (C02 family) 0.0014 0.0044 0.0044
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0091 0.0071
Onchocerca volvulus 0.003 0.0273 0.0744
Echinococcus granulosus zinc finger protein 0.0042 0.0429 0.0409
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0273 0.0253
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0681 0.4271
Brugia malayi hypothetical protein 0.0034 0.0321 0.048
Echinococcus granulosus neuropeptide FF receptor 2 0.003 0.0273 0.0253
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0485 0.41
Schistosoma mansoni hypothetical protein 0.003 0.0273 0.0273
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.003 0.0273 0.0253
Onchocerca volvulus 0.003 0.0262 0.0712
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0273 0.0253
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0317 0.0317
Echinococcus granulosus somatostatin receptor 0.003 0.0273 0.0253
Loa Loa (eye worm) calpain 0.0014 0.0044 0.0061
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0576 0.4908
Leishmania major cathepsin L-like protease 0.0046 0.0485 0.4101
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0273 0.0253
Trypanosoma brucei metacaspase 5, putative 0.0032 0.0292 0.2396
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.015 0.0207
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0017 0.00000000035835
Loa Loa (eye worm) hypothetical protein 0.014 0.1781 0.2831
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0273 0.0253
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0021 0.0011
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0203 0.055
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0091 0.0071
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.003 0.0273 0.0273
Leishmania major metacaspase, putative 0.0032 0.0292 0.2396
Echinococcus granulosus leucyl aminopeptidase 0.0019 0.0114 0.0094
Onchocerca volvulus 0.0034 0.0329 0.0909
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0021 0.0011
Echinococcus granulosus 7tm_1 domain containing protein 0.003 0.0273 0.0253
Trichomonas vaginalis set domain proteins, putative 0.0258 0.3409 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0781 0.0781
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0203 0.055
Brugia malayi calpain family protein 1 0.0036 0.0355 0.0535
Schistosoma mansoni opsin-like receptor 0.003 0.0273 0.0273
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0021 0.021
Schistosoma mansoni neuropeptide receptor 0.003 0.0273 0.0273
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0674 0.6847
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0021 0.021
Leishmania major hypothetical protein, conserved 0.0012 0.0021 0.0001
Loa Loa (eye worm) calpain family protein 1 0.0027 0.0223 0.0347
Echinococcus multilocularis apoptotic protease activating factor 1 0.003 0.0262 0.0242
Loa Loa (eye worm) hypothetical protein 0.0036 0.0355 0.0558
Brugia malayi Dopamine receptor protein 2 0.003 0.0273 0.0403
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0011
Toxoplasma gondii cathepsin CPL 0.0012 0.0021 0.016
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0049 0.0028
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0141 0.0193
Brugia malayi CXXC zinc finger family protein 0.0052 0.0568 0.0875
Onchocerca volvulus 0.0034 0.0329 0.0909
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0012 0.0021 0.0131
Schistosoma mansoni peptidylglycine monooxygenase 0.0012 0.0023 0.0023
Echinococcus multilocularis G protein coupled receptor 139 0.003 0.0273 0.0253
Loa Loa (eye worm) ctsf protein 0.0012 0.0021 0.0024
Schistosoma mansoni amine GPCR 0.003 0.0273 0.0273
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0014 0.0044 0.0206
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0273 0.0253
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0333 0.4434 0.7062
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0273 0.0253
Onchocerca volvulus 0.003 0.0273 0.0744
Schistosoma mansoni ap endonuclease 0.0059 0.0674 0.0674
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0012 0.0021 0.0001
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0331 0.0925
Echinococcus granulosus neuropeptide receptor A26 0.003 0.0273 0.0253
Trypanosoma cruzi metacaspase, putative 0.0032 0.0292 0.2495
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0091 0.0091
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0273 0.0426
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0006 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0021 0.0011
Echinococcus granulosus g protein coupled receptor 0.003 0.0273 0.0253
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.003 0.0273 0.0273
Onchocerca volvulus 0.003 0.0273 0.0744
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0153 0.0212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0021 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0012 0.0021 0.0011
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.032 0.03
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0331 0.0311
Chlamydia trachomatis cytosol aminopeptidase 0.0094 0.1152 0.5
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.015 0.0393
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0273 0.0253
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0092 0.0072
Loa Loa (eye worm) hypothetical protein 0.0034 0.0329 0.0515
Schistosoma mansoni bromodomain containing protein 0.0011 0.0013 0.0013
Leishmania major RNA-editing complex protein MP100, putative 0.0012 0.0021 0.0001
Schistosoma mansoni cpg binding protein 0.0058 0.066 0.066
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0273 0.0253
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.003 0.0273 0.0426
Mycobacterium tuberculosis Probable conserved membrane protein 0.0012 0.0023 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0017 0.00000000035835
Schistosoma mansoni ap endonuclease 0.0059 0.0674 0.0674
Brugia malayi GnHR receptor homolog 0.003 0.0273 0.0403
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0121 0.1522 0.1504
Echinococcus granulosus caspase 8 0.0032 0.0292 0.0272
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0103 0.1268 0.1994
Mycobacterium tuberculosis Probable lipase LipE 0.0034 0.0329 0.1078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0021 0.0011
Echinococcus multilocularis caspase 3 0.0052 0.0573 0.0553
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.003 0.0273 0.0253
Schistosoma mansoni hypothetical protein 0.0012 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.015 0.1983
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0329 0.2817
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0034 0.0329 0.1078
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0021 0.0209
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0091 0.0626
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0032 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0032 0.0043
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.298 0.4742
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0012 0.0021 0.0021
Entamoeba histolytica cysteine protease, putative 0.0012 0.0021 0.0209
Onchocerca volvulus 0.003 0.0273 0.0744
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0094 0.1152 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0426
Schistosoma mansoni neuropeptide f receptor 76f 0.003 0.0273 0.0273
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0674 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0006 0.0006
Schistosoma mansoni calpain-7 (C02 family) 0.0017 0.0083 0.0083
Echinococcus granulosus bloom syndrome protein 0.0021 0.015 0.013
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0084 0.1009 0.0991
Schistosoma mansoni synaptojanin 0.0012 0.0021 0.0021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0329 0.0329
Brugia malayi putative neuropeptide receptor NPR1 0.003 0.0273 0.0403
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0576 0.4481
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0012 0.0021 0.0131

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 9.8 nM BindingDB_Patents: Kinase Glo Luminescence Kinase Assay. Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a concentration of approx. 50-100 uM in test buffer (25 mM HEPES pH7.5; 25 mM MgCl2; 5 mM MnCl2; 50 mM KCl; 0.2% BSA; 0.01% CHAPS; 100 uM Na3VO4; 0.5 mM DTT) and 10% glycerol at -80 C until use. The catalytic activity of the GST-Syk kinase fusion protein was determined using the Kinase Glo Luminescence Kinase test (Promega; V6712). In this homogeneous test the amount of ATP remaining after the kinase reaction is quantified by a luciferin-luciferase reaction using luminescence. The luminescence signal obtained correlates with the amount of ATP still present and thus correlates inversely with the activity of the protein kinase. The test compounds were dissolved in 100% DMSO at a concentration of 10 mM and diluted in DMSO to a concentration of 1 mM. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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