Detailed information for compound 2069925

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 330.385 | Formula: C16H22N6O2
  • H donors: 2 H acceptors: 4 LogP: -0.26 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cnn(c1)CCC(=O)N1CCCC(C1)c1n[nH]c(c1)C(=O)N
  • InChi: 1S/C16H22N6O2/c1-11-8-18-22(9-11)6-4-15(23)21-5-2-3-12(10-21)13-7-14(16(17)24)20-19-13/h7-9,12H,2-6,10H2,1H3,(H2,17,24)(H,19,20)
  • InChiKey: NOIBFDNODMITDN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cytochrome p450-like protein 0.007 0.0396 0.025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.027 0.2867 0.3703
Echinococcus multilocularis glutathione S transferase 0.0047 0.0101 0.0131
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0051 0.015 0.0194
Echinococcus multilocularis voltage dependent calcium channel 0.0088 0.0618 0.0799
Schistosoma mansoni lamin 0.0088 0.0613 0.0792
Trypanosoma brucei unspecified product 0.0095 0.07 0.0561
Brugia malayi nuclear hormone receptor 0.027 0.2867 0.2867
Leishmania major cytochrome p450-like protein 0.007 0.0396 0.025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.0826 0.1067
Onchocerca volvulus 0.0052 0.0168 0.0156
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0143 0.129 0.129
Onchocerca volvulus 0.0052 0.0168 0.0156
Loa Loa (eye worm) hypothetical protein 0.0127 0.1101 0.1101
Onchocerca volvulus 0.0052 0.0168 0.0156
Brugia malayi RNA binding protein 0.0134 0.118 0.118
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0846 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0127 0.1101 0.1422
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0873 0.0736
Echinococcus granulosus lamin 0.0088 0.0613 0.0792
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0051 0.015 0.015
Schistosoma mansoni organic anion transporter 0.0052 0.0168 0.0217
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.027 0.2867 0.3703
Trypanosoma cruzi DNA polymerase kappa, putative 0.0109 0.0873 0.0733
Brugia malayi hypothetical protein 0.0127 0.1101 0.1101
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0051 0.015 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-3 0.027 0.2867 0.2867
Brugia malayi cytochrome P450 0.007 0.0396 0.0396
Brugia malayi hypothetical protein 0.0127 0.1101 0.1101
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.007 0.0396 0.025
Loa Loa (eye worm) nuclear receptor NHR-67 0.0127 0.1101 0.1101
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0127 0.1101 0.1101
Brugia malayi hypothetical protein 0.0052 0.0168 0.0168
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0105 0.0826 0.1067
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.027 0.2867 0.2867
Echinococcus multilocularis FTZ F1 alpha 0.027 0.2867 0.3703
Trichomonas vaginalis glucosylceramidase, putative 0.0593 0.6872 1
Trichomonas vaginalis glucosylceramidase, putative 0.0389 0.4345 0.6324
Loa Loa (eye worm) hypothetical protein 0.0127 0.1101 0.1101
Brugia malayi nuclear hormone receptor family member odr-7 0.0127 0.1101 0.1101
Echinococcus multilocularis thyroid hormone receptor alpha 0.027 0.2867 0.3703
Onchocerca volvulus 0.008 0.0515 0.0975
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0127 0.1101 0.1101
Schistosoma mansoni nuclear receptor nhr-48 0.0127 0.1101 0.1422
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.015 0.0218
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0088 0.0618 0.0799
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.027 0.2867 0.3703
Schistosoma mansoni retinoid-x-receptor (RXR) 0.027 0.2867 0.3703
Onchocerca volvulus 0.0052 0.0168 0.0156
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.0297 0.0297
Echinococcus multilocularis glutathione S transferase 0.0206 0.2079 0.2684
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0053 0.0178 0.0229
Loa Loa (eye worm) hypothetical protein 0.0051 0.015 0.015
Echinococcus multilocularis dna polymerase kappa 0.0109 0.0873 0.1127
Trichomonas vaginalis DNA polymerase eta, putative 0.0109 0.0873 0.127
Loa Loa (eye worm) hypothetical protein 0.0127 0.1101 0.1101
Entamoeba histolytica hypothetical protein 0.0076 0.0465 1
Brugia malayi Nuclear hormone receptor-like 1 0.027 0.2867 0.2867
Echinococcus multilocularis lamin dm0 0.0088 0.0613 0.0792
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.007 0.0396 0.3406
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0107 0.0848 0.9654
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0088 0.0618 0.0799
Schistosoma mansoni laminin gamma-3 chain 0.0185 0.1817 0.2347
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0088 0.0618 0.0799
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.007 0.0396 0.3406
Brugia malayi nuclear receptor NHR-67 0.0127 0.1101 0.1101
Brugia malayi Cytochrome P450 family protein 0.0107 0.0848 0.0848
Brugia malayi ecdysteroid receptor 0.027 0.2867 0.2867
Brugia malayi laminin alpha chain 0.0185 0.1817 0.1817
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0593 0.6872 0.6872
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0197 0.1965 0.1965
Schistosoma mansoni tar DNA-binding protein 0.0134 0.118 0.1524
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0109 0.0873 0.127
Toxoplasma gondii transporter, major facilitator family protein 0.0052 0.0168 0.0717
Brugia malayi Nuclear hormone receptor family member nhr-40 0.027 0.2867 0.2867
Echinococcus granulosus ecdysone induced protein 78C 0.027 0.2867 0.3703
Loa Loa (eye worm) hypothetical protein 0.0052 0.0168 0.0168
Trypanosoma cruzi cytochrome P450, putative 0.0107 0.0848 0.0708
Loa Loa (eye worm) hypothetical protein 0.0127 0.1101 0.1101
Onchocerca volvulus Putative organic anion transporter 0.0052 0.0168 0.0156
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.007 0.0396 0.3406
Echinococcus multilocularis synaptic glycoprotein sc2 0.0051 0.015 0.0194
Trypanosoma cruzi MFS transporter, putative 0.0052 0.0168 0.0018
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0127 0.1101 0.1422
Trypanosoma brucei DNA polymerase eta, putative 0.0053 0.0178 0.0031
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0088 0.0618 0.0799
Echinococcus multilocularis GPCR, family 2 0.0062 0.0297 0.0383
Loa Loa (eye worm) hypothetical protein 0.0086 0.0593 0.0593
Leishmania major lanosterol 14-alpha-demethylase, putative 0.007 0.0396 0.025
Loa Loa (eye worm) hypothetical protein 0.0052 0.0168 0.0168
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.027 0.2867 0.3703
Brugia malayi Steroid receptor seven-up type 2 0.027 0.2867 0.2867
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0051 0.015 0.0218
Schistosoma mansoni hypothetical protein 0.0059 0.0261 0.0336
Brugia malayi prostaglandin transporter 0.0052 0.0168 0.0168
Brugia malayi cytoplasmic intermediate filament protein 0.0047 0.0108 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0873 0.0736
Loa Loa (eye worm) hypothetical protein 0.0127 0.1101 0.1101
Onchocerca volvulus 0.0051 0.015 0.0115
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0051 0.015 0.0003
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.118 0.118
Loa Loa (eye worm) abnormal epIthelia family member 0.0185 0.1817 0.1817
Brugia malayi Calcitonin receptor-like protein seb-1 0.0197 0.1965 0.1965
Onchocerca volvulus Glucosylceramidase homolog 0.0389 0.4345 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0127 0.1101 0.1101
Loa Loa (eye worm) cytochrome P450 family protein 0.0107 0.0848 0.0848
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.007 0.0396 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.0297 0.0383
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.007 0.0396 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.007 0.0396 0.3406
Echinococcus multilocularis voltage dependent calcium channel 0.0088 0.0618 0.0799
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0105 0.0826 0.1067
Echinococcus granulosus voltage dependent calcium channel 0.0088 0.0618 0.0799
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.027 0.2867 0.2867
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.015 0.0218
Brugia malayi nuclear receptor RXR 0.0143 0.129 0.129
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0127 0.1101 0.1422
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.007 0.0396 1
Echinococcus granulosus neurogenic locus notch protein 0.0185 0.1817 0.2347
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0051 0.015 0.0194
Schistosoma mansoni nuclear hormone receptor 0.0127 0.1101 0.1422
Echinococcus granulosus nuclear receptor nhr 48 0.0127 0.1101 0.1422
Entamoeba histolytica hypothetical protein 0.0076 0.0465 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0109 0.0873 0.0733
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.007 0.0396 1
Plasmodium falciparum glutathione S-transferase 0.006 0.0273 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.007 0.0396 0.3406
Schistosoma mansoni tar DNA-binding protein 0.0134 0.118 0.1524
Brugia malayi ecdysone receptor 0.0127 0.1101 0.1101
Loa Loa (eye worm) hypothetical protein 0.0051 0.015 0.015
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0052 0.0168 0.0217
Mycobacterium ulcerans DNA polymerase IV 0.0109 0.0873 1
Brugia malayi TAR-binding protein 0.0134 0.118 0.118
Echinococcus granulosus geminin 0.0485 0.5524 0.7134
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.007 0.0396 0.3406
Brugia malayi conserved hypotetical protein 0.0127 0.1101 0.1101
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0088 0.0618 0.0799
Loa Loa (eye worm) cytochrome P450 0.007 0.0396 0.0396
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.007 0.0396 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.027 0.2867 0.2867
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.007 0.0396 1
Plasmodium vivax glutathione S-transferase, putative 0.0267 0.2826 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0105 0.0826 0.1067
Schistosoma mansoni nuclear hormone receptor 0.027 0.2867 0.3703
Loa Loa (eye worm) RNA binding protein 0.0134 0.118 0.118
Trichomonas vaginalis glucosylceramidase, putative 0.0593 0.6872 1
Schistosoma mansoni hypothetical protein 0.0485 0.5524 0.7134
Echinococcus granulosus intermediate filament protein 0.0088 0.0613 0.0792
Brugia malayi glutathione transferase 0.006 0.0273 0.0273
Echinococcus granulosus Solute carrier organic anion transporter family 0.0052 0.0168 0.0217
Loa Loa (eye worm) cytochrome P450 family protein 0.0107 0.0848 0.0848
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0088 0.0618 0.0618
Schistosoma mansoni terminal deoxycytidyl transferase 0.0053 0.0178 0.0229
Loa Loa (eye worm) hypothetical protein 0.027 0.2867 0.2867
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0067 0.035 0.0203
Giardia lamblia DINP protein human, muc B family 0.0067 0.035 1
Schistosoma mansoni DNA polymerase eta 0.0053 0.0178 0.0229
Trichomonas vaginalis glucosylceramidase, putative 0.0389 0.4345 0.6324
Brugia malayi Nuclear hormone receptor E75 0.0127 0.1101 0.1101
Schistosoma mansoni tar DNA-binding protein 0.0134 0.118 0.1524
Loa Loa (eye worm) hypothetical protein 0.0127 0.1101 0.1101
Schistosoma mansoni thyroid hormone receptor 0.027 0.2867 0.3703
Brugia malayi nuclear hormone receptor family member nhr-6 0.0127 0.1101 0.1101
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.007 0.0396 0.3406
Echinococcus multilocularis prostaglandin H2 D isomerase 0.0267 0.2826 0.365
Trichomonas vaginalis glucosylceramidase, putative 0.0389 0.4345 0.6324
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.027 0.2867 0.2867
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.007 0.0396 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0593 0.6872 0.6872
Trichomonas vaginalis glucosylceramidase, putative 0.041 0.4605 0.6701
Trichomonas vaginalis glucosylceramidase, putative 0.0593 0.6872 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0873 0.0736
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.027 0.2867 0.3703
Loa Loa (eye worm) hypothetical protein 0.0088 0.0613 0.0613
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.007 0.0396 0.3406
Echinococcus granulosus tar DNA binding protein 0.0134 0.118 0.1524
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0465 0.0601
Schistosoma mansoni RAR-like nuclear receptor 0.027 0.2867 0.3703
Loa Loa (eye worm) hypothetical protein 0.0047 0.0101 0.0101
Onchocerca volvulus Putative organic anion transporter 0.0052 0.0168 0.0156
Schistosoma mansoni slit 0.0185 0.1817 0.2347
Echinococcus granulosus glutathione s transferase mu 0.006 0.0273 0.0352
Echinococcus granulosus L aminoadipate semialdehyde 0.008 0.0515 0.0665
Loa Loa (eye worm) hypothetical protein 0.008 0.0515 0.0515
Echinococcus granulosus microtubule associated protein 2 0.0664 0.7743 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.007 0.0396 0.3406
Brugia malayi tailless protein 0.0127 0.1101 0.1101
Loa Loa (eye worm) hypothetical protein 0.006 0.0273 0.0273
Echinococcus granulosus glutathione S transferase Mu 1 0.006 0.0273 0.0352
Brugia malayi hypothetical protein 0.0143 0.129 0.129
Loa Loa (eye worm) hypothetical protein 0.0062 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0073 0.0422 0.0422
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.007 0.0396 0.3406
Echinococcus multilocularis lamin 0.0088 0.0613 0.0792
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0042 0.005 0.0065
Schistosoma mansoni microtubule-associated protein tau 0.0664 0.7743 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.007 0.0396 0.3406
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.007 0.0396 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.003 0.003
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0042 0.005 0.0065
Echinococcus multilocularis nuclear receptor nhr 48 0.0127 0.1101 0.1422
Schistosoma mansoni hypothetical protein 0.0062 0.0297 0.0383
Loa Loa (eye worm) hypothetical protein 0.0127 0.1101 0.1101
Schistosoma mansoni zinc finger protein 0.0127 0.1101 0.1422
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0053 0.0178 0.0229
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.008 0.0515 0.0665
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.007 0.0396 1
Echinococcus multilocularis microtubule associated protein 2 0.0664 0.7743 1
Loa Loa (eye worm) hypothetical protein 0.0185 0.1817 0.1817
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0051 0.015 0.0218
Brugia malayi nuclear receptor NHR-88 0.027 0.2867 0.2867
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.007 0.0396 0.3406
Echinococcus granulosus lamin dm0 0.0088 0.0613 0.0792
Echinococcus granulosus thyroid hormone receptor alpha 0.0127 0.1101 0.1422
Schistosoma mansoni lamin 0.0088 0.0613 0.0792
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0053 0.0178 0.0229
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.027 0.2867 0.3703
Brugia malayi hypothetical protein 0.0052 0.0168 0.0168
Leishmania major DNA polymerase kappa, putative 0.0067 0.035 0.0203
Loa Loa (eye worm) hypothetical protein 0.0143 0.129 0.129
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.027 0.2867 0.2867
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.027 0.2867 0.6517
Brugia malayi Intermediate filament tail domain containing protein 0.0088 0.0613 0.0613
Schistosoma mansoni hypothetical protein 0.0062 0.0297 0.0383
Onchocerca volvulus 0.0127 0.1101 0.2356
Loa Loa (eye worm) hypothetical protein 0.0185 0.1817 0.1817
Schistosoma mansoni retinoic acid receptor RXR 0.0478 0.5443 0.703
Brugia malayi sodium-independent organic anion transporter family protein 0.0052 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0127 0.1101 0.1101
Leishmania major C-8 sterol isomerase-like protein 0.0846 1 1
Echinococcus granulosus pikachurin 0.0185 0.1817 0.2347
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.027 0.2867 0.3703
Mycobacterium ulcerans DNA polymerase IV 0.0109 0.0873 1
Loa Loa (eye worm) TAR-binding protein 0.0134 0.118 0.118
Brugia malayi EGF-like domain containing protein 0.0185 0.1817 0.1817
Brugia malayi laminin-like protein K08C7.3 precursor 0.0185 0.1817 0.1817
Brugia malayi Nuclear hormone receptor family member nhr-25 0.027 0.2867 0.2867
Brugia malayi sodium-independent organic anion transporter family protein 0.0052 0.0168 0.0168
Schistosoma mansoni hypothetical protein 0.0062 0.0297 0.0383
Schistosoma mansoni glutathione-S-transferase 0.006 0.0273 0.0352
Brugia malayi Cytochrome P450 family protein 0.0107 0.0848 0.0848
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.027 0.2867 0.3703
Trypanosoma brucei DNA polymerase IV, putative 0.0109 0.0873 0.0736
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.007 0.0396 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.027 0.2867 0.2867
Brugia malayi Nuclear hormone receptor family member nhr-14 0.027 0.2867 0.2867
Loa Loa (eye worm) hypothetical protein 0.0143 0.129 0.129
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0127 0.1101 0.2356
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.007 0.0396 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.007 0.0396 0.3406
Loa Loa (eye worm) hypothetical protein 0.027 0.2867 0.2867
Brugia malayi latrophilin 2 splice variant baaae 0.0135 0.1193 0.1193
Schistosoma mansoni hypothetical protein 0.0076 0.0465 0.0601
Echinococcus multilocularis glutathione S transferase 0.0047 0.0101 0.0131
Echinococcus granulosus nuclear receptor 2DBD gamma 0.027 0.2867 0.3703
Echinococcus granulosus slit 2 protein 0.0185 0.1817 0.2347
Schistosoma mansoni Tr4/Tr2 (homologue) 0.027 0.2867 0.3703
Mycobacterium leprae putative cytochrome p450 0.007 0.0396 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.027 0.2867 0.3703
Echinococcus multilocularis slit 2 protein 0.0185 0.1817 0.2347
Loa Loa (eye worm) hypothetical protein 0.027 0.2867 0.2867
Onchocerca volvulus 0.0052 0.0168 0.0156
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.007 0.0396 0.3406
Echinococcus multilocularis musashi 0.0088 0.0613 0.0792
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0067 0.035 0.789
Schistosoma mansoni organic anion transporter 0.0052 0.0168 0.0217
Trypanosoma cruzi DNA polymerase kappa, putative 0.0109 0.0873 0.0733
Trichomonas vaginalis glucosylceramidase, putative 0.0593 0.6872 1
Brugia malayi nuclear receptor NHR-88 0.0127 0.1101 0.1101
Echinococcus granulosus glutathione S transferase 0.0047 0.0101 0.0131
Echinococcus multilocularis tar DNA binding protein 0.0134 0.118 0.1524
Loa Loa (eye worm) hypothetical protein 0.0052 0.0168 0.0168
Onchocerca volvulus Bile acid receptor homolog 0.027 0.2867 0.6517
Trichomonas vaginalis glutaminyl-tRNA synthetase, putative 0.0047 0.0101 0.0148
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0105 0.0826 0.1067
Trichomonas vaginalis glucosylceramidase, putative 0.0389 0.4345 0.6324
Trichomonas vaginalis glucosylceramidase, putative 0.0389 0.4345 0.6324
Echinococcus granulosus GPCR family 2 0.0062 0.0297 0.0383
Loa Loa (eye worm) hypothetical protein 0.027 0.2867 0.2867
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.007 0.0396 1
Loa Loa (eye worm) hypothetical protein 0.027 0.2867 0.2867
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.027 0.2867 0.2867
Onchocerca volvulus 0.0088 0.0613 0.1206
Echinococcus multilocularis glutathione s transferase mu 0.006 0.0273 0.0352
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0062 0.0297 0.0383
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0465 0.0601
Leishmania major DNA polymerase eta, putative 0.0053 0.0178 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0389 0.4345 0.6324
Loa Loa (eye worm) hypothetical protein 0.0846 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0105 0.0826 0.0826
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.007 0.0396 0.3406
Echinococcus multilocularis dna polymerase eta 0.0053 0.0178 0.0229
Echinococcus multilocularis glutathione S transferase 0.006 0.0273 0.0352
Loa Loa (eye worm) hypothetical protein 0.0052 0.0168 0.0168
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0052 0.0168 0.0168
Schistosoma mansoni nuclear hormone receptor 0.0127 0.1101 0.1422
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0127 0.1101 0.2356
Echinococcus granulosus expressed protein 0.0404 0.4522 0.5841
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0127 0.1101 0.1422
Echinococcus multilocularis L aminoadipate semialdehyde 0.008 0.0515 0.0665
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0185 0.1817 0.2347
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.027 0.2867 0.3703
Entamoeba histolytica hypothetical protein 0.0076 0.0465 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0143 0.129 0.1667
Brugia malayi Nuclear hormone receptor family member nhr-1 0.027 0.2867 0.2867
Toxoplasma gondii cytochrome p450 superfamily protein 0.007 0.0396 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0127 0.1101 0.1422
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.007 0.0396 1
Trypanosoma brucei DNA polymerase IV, putative 0.0109 0.0873 0.0736
Echinococcus granulosus FTZ F1 alpha 0.027 0.2867 0.3703
Loa Loa (eye worm) calcium channel 0.0088 0.0618 0.0618
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0052 0.0168 0.0217
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0873 0.0736
Loa Loa (eye worm) hypothetical protein 0.0041 0.003 0.003
Loa Loa (eye worm) cytochrome P450 family protein 0.012 0.1014 0.1014
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0127 0.1101 0.1422
Loa Loa (eye worm) steroid hormone receptor 0.027 0.2867 0.2867
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0051 0.015 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.035 0.0206
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.027 0.2867 0.3703
Echinococcus granulosus prostaglandin H2 D isomerase 0.0267 0.2826 0.365
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0873 0.0736
Entamoeba histolytica hypothetical protein 0.0076 0.0465 1
Loa Loa (eye worm) hypothetical protein 0.027 0.2867 0.2867
Echinococcus granulosus glutathione S transferase 0.0206 0.2079 0.2684
Brugia malayi hypothetical protein 0.0076 0.0465 0.0465
Brugia malayi ImpB/MucB/SamB family protein 0.0053 0.0178 0.0178
Echinococcus granulosus dna polymerase eta 0.0053 0.0178 0.0229
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.007 0.0396 0.3406
Brugia malayi orphan nuclear receptor NR2E1 0.0127 0.1101 0.1101
Schistosoma mansoni nuclear receptor 0.0127 0.1101 0.1422
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0492 0.5611 0.5611
Onchocerca volvulus 0.0127 0.1101 0.2356
Brugia malayi sodium-independent organic anion transporter family protein 0.0052 0.0168 0.0168
Trypanosoma brucei cytochrome P450, putative 0.0107 0.0848 0.0711
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.007 0.0396 0.3406
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.007 0.0396 1
Echinococcus multilocularis geminin 0.0485 0.5524 0.7134
Schistosoma mansoni voltage-gated cation channel 0.0088 0.0618 0.0799
Brugia malayi Nuclear hormone receptor family member nhr-49 0.027 0.2867 0.2867
Echinococcus granulosus Nuclear hormone receptor HR96 0.0127 0.1101 0.1422
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0088 0.0618 0.0799
Loa Loa (eye worm) hypothetical protein 0.027 0.2867 0.2867
Brugia malayi Nuclear hormone receptor E75 0.0127 0.1101 0.1101
Echinococcus multilocularis glutathione S transferase 0.006 0.0273 0.0352
Brugia malayi follicle stimulating hormone receptor 0.0492 0.5611 0.5611
Schistosoma mansoni Glutathione S-transferase 28 kDa (GST 28) (GST class-mu) 0.0267 0.2826 0.365
Loa Loa (eye worm) hypothetical protein 0.0052 0.0168 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0873 0.0736
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0873 0.0736
Brugia malayi nuclear receptor RXR 0.0127 0.1101 0.1101
Brugia malayi nuclear hormone receptor 0.0127 0.1101 0.1101
Onchocerca volvulus 0.0088 0.0613 0.1206
Entamoeba histolytica deoxycytidyl transferase, putative 0.0053 0.0178 0.0875
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.007 0.0396 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0047 0.0108 0.0108
Trypanosoma brucei C-8 sterol isomerase, putative 0.0846 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.0826 0.1067
Brugia malayi Nuclear hormone receptor family member nhr-19 0.027 0.2867 0.2867
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0054 0.019 0.0043
Brugia malayi hypothetical protein 0.0143 0.129 0.129
Trypanosoma brucei DNA polymerase IV, putative 0.0095 0.07 0.0561
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0054 0.019 0.0041
Schistosoma mansoni cell polarity protein 0.0185 0.1817 0.2347
Mycobacterium leprae Conserved hypothetical protein 0.007 0.0396 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.0168 0.0168
Schistosoma mansoni hypothetical protein 0.0135 0.1193 0.1541
Loa Loa (eye worm) hypothetical protein 0.0127 0.1101 0.1101
Schistosoma mansoni nuclear receptor 0.0127 0.1101 0.1422
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.0826 0.1067
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0143 0.129 0.1667
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0088 0.0618 0.0799
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0143 0.129 0.1667
Loa Loa (eye worm) hypothetical protein 0.0127 0.1101 0.1101
Loa Loa (eye worm) hypothetical protein 0.027 0.2867 0.2867
Trichomonas vaginalis glucosylceramidase, putative 0.0593 0.6872 1
Trichomonas vaginalis glucosylceramidase, putative 0.0389 0.4345 0.6324
Onchocerca volvulus 0.027 0.2867 0.6517
Echinococcus granulosus glutathione S transferase 0.006 0.0273 0.0352
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0051 0.015 0.0218
Schistosoma mansoni hypothetical protein 0.0062 0.0297 0.0383
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.027 0.2867 0.3703
Trichomonas vaginalis glucosylceramidase, putative 0.0593 0.6872 1
Onchocerca volvulus Putative organic anion transporter 0.0052 0.0168 0.0156
Echinococcus granulosus nuclear receptor 2DBD gamma 0.027 0.2867 0.3703
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.007 0.0396 0.3406
Brugia malayi Glutathione S-transferase 4 0.0047 0.0101 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-19 0.027 0.2867 0.2867
Loa Loa (eye worm) hypothetical protein 0.0042 0.005 0.005
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.008 0.0515 0.0515
Echinococcus granulosus cytochrome P450 2K1 0.007 0.0396 0.0512
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0335 0.3678 0.475
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0088 0.0618 0.0799
Schistosoma mansoni thyroid hormone receptor 0.027 0.2867 0.3703
Trypanosoma cruzi cytochrome p450-like protein, putative 0.007 0.0396 0.025
Brugia malayi Nuclear hormone receptor-like 1 0.0143 0.129 0.129
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0051 0.015 0.0194
Loa Loa (eye worm) hypothetical protein 0.0143 0.129 0.129
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0052 0.0168 0.0217
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.007 0.0396 0.3406
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.007 0.0396 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.0297 0.0297
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0051 0.015 0.0003
Loa Loa (eye worm) nuclear hormone receptor 0.0127 0.1101 0.1101
Schistosoma mansoni tar DNA-binding protein 0.0134 0.118 0.1524
Echinococcus multilocularis pikachurin 0.0185 0.1817 0.2347
Echinococcus granulosus Nuclear hormone receptor HR96 0.0127 0.1101 0.1422
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0127 0.1101 0.1422
Echinococcus granulosus dna polymerase kappa 0.0109 0.0873 0.1127
Echinococcus multilocularis glutathione S transferase 0.006 0.0273 0.0352
Schistosoma mansoni tar DNA-binding protein 0.0134 0.118 0.1524
Trichomonas vaginalis glucosylceramidase, putative 0.041 0.4605 0.6701
Trypanosoma cruzi DNA polymerase kappa, putative 0.0109 0.0873 0.0733
Loa Loa (eye worm) hypothetical protein 0.0433 0.4879 0.4879
Echinococcus multilocularis 0.007 0.0396 0.0512
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.007 0.0396 0.3406
Brugia malayi photoreceptor-specific nuclear receptor 0.027 0.2867 0.2867
Echinococcus granulosus synaptic glycoprotein sc2 0.0051 0.015 0.0194
Loa Loa (eye worm) hypothetical protein 0.0143 0.129 0.129
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0422 0.0279
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0143 0.129 0.1667
Loa Loa (eye worm) hypothetical protein 0.0197 0.1965 0.1965
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0062 0.0297 0.0383
Brugia malayi polk-prov protein 0.0073 0.0422 0.0422
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0873 0.0736
Loa Loa (eye worm) hypothetical protein 0.0051 0.015 0.015
Echinococcus multilocularis expressed protein 0.0404 0.4522 0.5841
Schistosoma mansoni hypothetical protein 0.0485 0.5524 0.7134
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.007 0.0396 1
Loa Loa (eye worm) hypothetical protein 0.0127 0.1101 0.1101
Brugia malayi Nuclear hormone receptor-like 1 0.0143 0.129 0.129
Leishmania major cytochrome p450-like protein 0.0107 0.0848 0.0708
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.007 0.0396 0.0252
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.007 0.0396 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.027 0.2867 0.2867
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.027 0.2867 0.3703
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.007 0.0396 0.025
Loa Loa (eye worm) hypothetical protein 0.0127 0.1101 0.1101
Onchocerca volvulus Protein ultraspiracle homolog 0.027 0.2867 0.6517
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0088 0.0613 0.0613
Loa Loa (eye worm) DR-78 0.0127 0.1101 0.1101
Brugia malayi Cytochrome P450 family protein 0.007 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0088 0.0618 0.0618
Brugia malayi intermediate filament protein 0.0088 0.0613 0.0613
Brugia malayi ImpB/MucB/SamB family protein 0.0053 0.0178 0.0178
Brugia malayi Cytochrome P450 family protein 0.012 0.1014 0.1014
Trypanosoma cruzi DNA polymerase eta, putative 0.0053 0.0178 0.0028
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.007 0.0396 1
Echinococcus multilocularis glutathione S-transferase 0.006 0.0273 0.0352
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.0297 0.0383
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0185 0.1817 0.1817
Schistosoma mansoni hypothetical protein 0.007 0.0396 0.0512
Brugia malayi Latrophilin receptor protein 2 0.0062 0.0297 0.0297
Schistosoma mansoni intermediate filament proteins 0.0088 0.0613 0.0792
Brugia malayi Nuclear hormone receptor family member nhr-25 0.027 0.2867 0.2867
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.027 0.2867 0.3703
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.0422 0.0279
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0197 0.1965 0.1965
Schistosoma mansoni cytochrome P450 0.007 0.0396 0.0512
Loa Loa (eye worm) CYP4Cod1 0.0107 0.0848 0.0848
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0053 0.0178 0.0178
Brugia malayi steroid hormone receptor 0.027 0.2867 0.2867
Schistosoma mansoni GST class-mu 0.006 0.0273 0.0352
Loa Loa (eye worm) hypothetical protein 0.0135 0.1193 0.1193
Brugia malayi Nuclear hormone receptor family member nhr-31 0.027 0.2867 0.2867
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0088 0.0618 0.0799
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.007 0.0396 1
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0051 0.015 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0873 0.0736
Trypanosoma cruzi cytochrome P450, putative 0.0107 0.0848 0.0708
Loa Loa (eye worm) hypothetical protein 0.0185 0.1817 0.1817
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.118 0.118
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0465 0.0601
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.027 0.2867 0.2867
Schistosoma mansoni coup transcription factor 0.027 0.2867 0.3703
Schistosoma mansoni steroid hormone receptor ad4bp 0.027 0.2867 0.3703
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.027 0.2867 0.2867
Echinococcus multilocularis neurogenic locus notch protein 0.0185 0.1817 0.2347
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0051 0.015 0.0218
Loa Loa (eye worm) intermediate filament protein 0.0088 0.0613 0.0613
Loa Loa (eye worm) hypothetical protein 0.0053 0.0178 0.0178
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0051 0.015 0.0218
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0127 0.1101 0.1422
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0478 0.5443 0.703
Echinococcus multilocularis ecdysone induced protein 78C 0.027 0.2867 0.3703
Brugia malayi Synaptic glycoprotein SC2 0.0051 0.015 0.015
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0105 0.0826 0.0826
Loa Loa (eye worm) hypothetical protein 0.0143 0.129 0.129

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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