Detailed information for compound 21549

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 518.597 | Formula: C31H34O7
  • H donors: 2 H acceptors: 5 LogP: 5.07 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC(=O)COc1ccc(cc1)C(c1ccc(cc(=O)c1O)C(C)C)c1ccc(cc(=O)c1O)C(C)C
  • InChi: 1S/C31H34O7/c1-6-37-28(34)17-38-23-11-7-20(8-12-23)29(24-13-9-21(18(2)3)15-26(32)30(24)35)25-14-10-22(19(4)5)16-27(33)31(25)36/h7-16,18-19,29H,6,17H2,1-5H3,(H,32,35)(H,33,36)
  • InChiKey: AMOPXASPRMSLGJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0251 0.1141 0.1141
Trypanosoma cruzi cruzipain precursor, putative 0.0083 0.0299 0.0512
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0314 0.1452 0.1452
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0071 0.0209
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0067 0.0219 0.0361
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0096 0.0247
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0294 0.0501
Brugia malayi beta-lactamase family protein 0.0037 0.0071 0.0071
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0061 0.019 0.049
Schistosoma mansoni hypothetical protein 0.0102 0.0395 0.0395
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0096 0.0247
Entamoeba histolytica cysteine protease, putative 0.0029 0.0028 0.0264
Onchocerca volvulus 0.005 0.0133 0.0343
Schistosoma mansoni hypothetical protein 0.0066 0.0217 0.0217
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0029 0.0029
Loa Loa (eye worm) trypsin family protein 0.0066 0.0217 0.0217
Echinococcus multilocularis enteropeptidase 0.0066 0.0217 0.0559
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0096 0.0364 0.3448
Schistosoma mansoni hypothetical protein 0.0068 0.0226 0.0226
Toxoplasma gondii subtilisin SUB7 0.0063 0.0197 0.051
Echinococcus granulosus caspase 2 0.01 0.0385 0.0994
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0299 0.0519
Toxoplasma gondii aldehyde dehydrogenase 0.0124 0.0503 0.13
Leishmania major mitochondrial DNA polymerase beta 0.0314 0.1453 0.2728
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0096 0.0247
Schistosoma mansoni smad1 5 8 and 0.0032 0.0047 0.0047
Schistosoma mansoni importin beta-1 0.0028 0.0024 0.0024
Onchocerca volvulus 0.0066 0.0217 0.056
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0096 0.0364 0.0364
Brugia malayi beta-lactamase family protein 0.0037 0.0071 0.0071
Brugia malayi hypothetical protein 0.0044 0.0107 0.0107
Schistosoma mansoni cathepsin D (A01 family) 0.0251 0.1138 0.1138
Loa Loa (eye worm) PAN domain-containing protein 0.005 0.0133 0.0133
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0096 0.0096
Mycobacterium tuberculosis Possible exported protein 0.0496 0.2363 0.6972
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0299 0.0519
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0082 0.0294 0.7388
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0028 0.0264
Echinococcus multilocularis calpain 7 (C02 family) 0.0067 0.0219 0.0567
Loa Loa (eye worm) prolyl oligopeptidase 0.0255 0.1159 0.1159
Onchocerca volvulus 0.0029 0.0028 0.0072
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0096 0.0096
Trypanosoma cruzi major cysteine proteinase, putative 0.0067 0.0221 0.0363
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0246 0.1113 0.1113
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0325 0.151 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0028 0.0264
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.014 0.0586 0.0586
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Schistosoma mansoni inositol monophosphatase 0.0079 0.0278 0.0278
Schistosoma mansoni Smad4 0.0032 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0037 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0246 0.1113 0.1113
Onchocerca volvulus Cell death protein 3 homolog 0.01 0.0385 0.0994
Schistosoma mansoni hypothetical protein 0.0338 0.1575 0.1575
Echinococcus granulosus prolyl endopeptidase 0.0797 0.3869 1
Loa Loa (eye worm) hypothetical protein 0.0557 0.2666 0.2666
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0243 0.0629
Trypanosoma cruzi hypothetical protein, conserved 0.0096 0.0364 0.0634
Trypanosoma cruzi prefoldin subunit, putative 0.0068 0.0226 0.0373
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0325 0.151 0.2798
Loa Loa (eye worm) hypothetical protein 0.0082 0.0294 0.0294
Echinococcus multilocularis GA binding protein alpha chain 0.0078 0.0276 0.0714
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0217 0.0217
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0096 0.0247
Loa Loa (eye worm) hypothetical protein 0.0111 0.0437 0.0437
Loa Loa (eye worm) PAN domain-containing protein 0.005 0.0133 0.0133
Entamoeba histolytica prefoldin subunit 6, putative 0.0068 0.0226 0.2136
Brugia malayi cathepsin B-like cysteine proteinase 0.0314 0.1452 0.1452
Brugia malayi calpain 7 0.0067 0.0219 0.0219
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0063 0.0197 0.0877
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0071 0.179
Schistosoma mansoni hypothetical protein 0.0066 0.0217 0.0217
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0797 0.3869 0.7265
Schistosoma mansoni furin-1 (S08 family) 0.0063 0.0197 0.0197
Echinococcus granulosus GA binding protein alpha chain 0.0078 0.0276 0.0714
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0105 0.0146
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0025 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0028 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0197 0.1868
Loa Loa (eye worm) hypothetical protein 0.0066 0.0217 0.0217
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0299 0.0519
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0124 0.0503 0.1299
Giardia lamblia Alanyl dipeptidyl peptidase 0.0096 0.0364 0.3264
Toxoplasma gondii hypothetical protein 0.005 0.0133 0.0343
Schistosoma mansoni hypothetical protein 0.0072 0.0243 0.0243
Entamoeba histolytica calpain large subunit domain III containing protein 0.0047 0.0119 0.1125
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0234 0.1056 1
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0325 0.151 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0278 0.2633
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0255 0.1159 0.1159
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Plasmodium vivax calpain, putative 0.0067 0.0219 0.552
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.014 0.0586 0.1053
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0063 0.0197 0.0197
Onchocerca volvulus 0.0029 0.0028 0.0072
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0096 0.0247
Entamoeba histolytica prolyl oligopeptidase family protein 0.0096 0.0364 0.3448
Echinococcus granulosus peregrin 0.0029 0.0029 0.0074
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0154 0.0237
Plasmodium falciparum peptidase, putative 0.0096 0.0364 0.916
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0105 0.0153
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0155 0.0658 0.6228
Toxoplasma gondii subtilisin SUB10 0.0063 0.0197 0.051
Echinococcus granulosus calpain 7 C02 family 0.0067 0.0219 0.0567
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0037 0.0071 0.0071
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0314 0.1452 0.1452
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0079 0.0278 0.5
Onchocerca volvulus 0.0029 0.0031 0.0079
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0063 0.0197 0.0877
Echinococcus granulosus cathepsin L cysteine proteinase 0.0029 0.0028 0.0072
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0023 0 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0096 0.0096
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0063 0.0197 0.0877
Brugia malayi calpain family protein 1 0.0177 0.0772 0.0772
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Schistosoma mansoni hypothetical protein 0.0362 0.1691 0.1691
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0029 0.0074
Echinococcus granulosus inhibitor of apoptosis protein 0.0362 0.1691 0.4371
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Loa Loa (eye worm) hypothetical protein 0.0096 0.0364 0.0364
Onchocerca volvulus 0.005 0.0133 0.0343
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0071 0.0673
Brugia malayi Importin beta-1 subunit 0.0028 0.0024 0.0024
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0096 0.0364 0.0364
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0299 0.0519
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0325 0.151 0.2836
Plasmodium vivax aspartyl protease, putative 0.0103 0.0397 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0201 0.0201
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.058 0.058
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0096 0.0096
Brugia malayi PAN domain containing protein 0.005 0.0133 0.0133
Entamoeba histolytica hypothetical protein 0.0072 0.0243 0.2305
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0219 0.0361
Giardia lamblia Cathepsin B precursor 0.0106 0.0414 0.3752
Brugia malayi prolyl oligopeptidase family protein 0.014 0.0586 0.0586
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0243 0.0629
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0096 0.0364 0.3448
Onchocerca volvulus 0.0042 0.0096 0.0247
Plasmodium falciparum plasmepsin VI 0.0061 0.019 0.4774
Onchocerca volvulus 0.005 0.0133 0.0343
Plasmodium vivax aspartyl protease, putative 0.0103 0.0397 1
Brugia malayi prolyl oligopeptidase family protein 0.0255 0.1159 0.1159
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0299 0.0519
Loa Loa (eye worm) hypothetical protein 0.05 0.2384 0.2384
Onchocerca volvulus Alhambra homolog 0.0029 0.0029 0.0075
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.0047 0.0047
Echinococcus multilocularis inositol monophosphatase 1 0.0079 0.0278 0.0718
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0217 0.0217
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0066 0.0217 0.0217
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.005 0.0133 0.0133
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0325 0.151 0.2798
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0217 0.0217
Brugia malayi Bromodomain containing protein 0.0029 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.01 0.0385 0.0385
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0028 0.0264
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0314 0.1452 0.1452
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0226 0.2136
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0024 0.0062
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0356 0.0921
Onchocerca volvulus 0.005 0.0133 0.0343
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0255 0.1159 0.2996
Toxoplasma gondii hypothetical protein 0.005 0.0133 0.0343
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0096 0.0096
Echinococcus multilocularis inhibitor of apoptosis protein 0.0362 0.1691 0.4371
Plasmodium falciparum cysteine proteinase falcipain 3 0.0029 0.0028 0.0704
Brugia malayi NAD-dependent deacetylase SIRT1 0.0155 0.0658 0.0658
Echinococcus multilocularis calpain family protein 1, d 0.0131 0.0538 0.1389
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0066 0.0217 0.0217
Brugia malayi PAN domain containing protein 0.005 0.0133 0.0133
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Brugia malayi Trypsin-like protease protein 5 0.0066 0.0217 0.0217
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0071 0.0071
Onchocerca volvulus 0.01 0.0385 0.0994
Entamoeba histolytica prolyl oligopeptidase family protein 0.0096 0.0364 0.3448
Echinococcus granulosus calpain 0.0067 0.0219 0.0567
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Echinococcus granulosus membrane bound transcription factor site 1 0.0063 0.0197 0.051
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0234 0.1056 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0096 0.0096
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.1453 0.2689
Echinococcus granulosus cathepsin b 0.0314 0.1452 0.3754
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0031 0.0079
Brugia malayi PAN domain containing protein 0.005 0.0133 0.0133
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0048 0.0126 0.0237
Loa Loa (eye worm) subtilase 0.2025 1 1
Onchocerca volvulus 0.0029 0.0028 0.0072
Brugia malayi MH1 domain containing protein 0.0032 0.0047 0.0047
Brugia malayi neuroendocrine convertase 1 precursor 0.0063 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0362 0.1691 0.1691
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0096 0.0364 0.3448
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0031 0.0079
Loa Loa (eye worm) transcriptional regulator 0.0048 0.0126 0.0126
Loa Loa (eye worm) inositol-1 0.0079 0.0278 0.0278
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0126 0.3177
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.058 0.15
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0758 0.3672 0.9492
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0071 0.0673
Leishmania major cysteine peptidase A (CPA) 0.0029 0.0028 0.0052
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0066 0.0217 0.0217
Loa Loa (eye worm) RNA binding protein 0.0063 0.0201 0.0201
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0048 0.0126 0.0326
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0219 0.0412
Loa Loa (eye worm) hypothetical protein 0.0053 0.0151 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0197 0.1868
Onchocerca volvulus Prolyl endopeptidase homolog 0.0797 0.3869 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0096 0.0096
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0189 0.0831 0.0831
Plasmodium falciparum plasmepsin X 0.0103 0.0397 1
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0066 0.0217 0.0559
Plasmodium falciparum cysteine repeat modular protein 1 0.0082 0.0294 0.7388
Echinococcus granulosus cathepsin l cysteine peptidase 0.0029 0.0028 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0201 0.0201
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0278 0.0479
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0028 0.0264
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0124 0.0503 0.1299
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0197 0.1868
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0078 0.0276 0.0276
Plasmodium vivax subtilisin-like protease 2, putative 0.0063 0.0197 0.4966
Mycobacterium ulcerans Sir2-like regulatory protein 0.0048 0.0126 0.0383
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0362 0.1691 0.1691
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0061 0.019 0.049
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0096 0.0096
Leishmania major cathepsin L-like protease 0.0083 0.0299 0.0562
Mycobacterium tuberculosis Conserved protein 0.0037 0.0071 0.0209
Leishmania major hypothetical protein, conserved 0.0037 0.0071 0.0133
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0071 0.0673
Loa Loa (eye worm) hypothetical protein 0.005 0.0133 0.0133
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0071 0.0071
Entamoeba histolytica hypothetical protein, conserved 0.0096 0.0364 0.3448
Echinococcus granulosus neuroendocrine convertase 2 0.0063 0.0197 0.051
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0151 0.0232
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0071 0.0209
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0031 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0096 0.0096
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0063 0.0197 0.0877
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0028 0.0264
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0102 0.0395 0.0395
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0096 0.0247
Echinococcus multilocularis hypothetical protein 0.0067 0.0219 0.0567
Plasmodium vivax subtilisin-like serine protease, putative 0.0063 0.0197 0.4966
Toxoplasma gondii PAN domain-containing protein 0.005 0.0133 0.0343
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.0047 0.0121
Loa Loa (eye worm) hypothetical protein 0.0042 0.0096 0.0096
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0151 0.3801
Loa Loa (eye worm) calpain 5 0.0047 0.0119 0.0119
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0126 0.1195
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0096 0.0247
Trypanosoma brucei subtilisin peptidase 0.0063 0.0197 0.0327
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0048 0.0126 0.0186
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0063 0.0197 0.032
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0217 0.0217
Loa Loa (eye worm) calpain 0.0067 0.0219 0.0219
Toxoplasma gondii aspartyl protease ASP1 0.0061 0.019 0.049
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0071 0.0209
Brugia malayi transcriptional regulator, Sir2 family protein 0.0234 0.1056 0.1056
Brugia malayi TAR-binding protein 0.0063 0.0201 0.0201
Brugia malayi hypothetical protein 0.0034 0.0057 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0096 0.0096
Trypanosoma brucei prolyl endopeptidase 0.0797 0.3869 0.7252
Loa Loa (eye worm) beta-lactamase 0.0037 0.0071 0.0071
Onchocerca volvulus 0.0063 0.0197 0.051
Plasmodium vivax vivapain-2 0.0029 0.0028 0.0704
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0217 0.0217
Onchocerca volvulus 0.0082 0.0294 0.0759
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0096 0.0364 0.3448
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0096 0.0364 0.0941
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0278 0.0522
Echinococcus multilocularis glycoprotein Antigen 5 0.0066 0.0217 0.0559
Toxoplasma gondii subtilisin SUB8 0.0063 0.0197 0.051
Loa Loa (eye worm) hypothetical protein 0.005 0.0133 0.0133
Echinococcus multilocularis apoptotic protease activating factor 1 0.01 0.0385 0.0994
Loa Loa (eye worm) hypothetical protein 0.0362 0.1691 0.1691
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0503 0.0503
Echinococcus multilocularis peregrin 0.0029 0.0029 0.0074
Brugia malayi celfurPC protein 0.0063 0.0197 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0096 0.0096
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0155 0.0658 0.6228
Toxoplasma gondii cathepsin CPL 0.0029 0.0028 0.0072
Onchocerca volvulus 0.0066 0.0217 0.056
Loa Loa (eye worm) hypothetical protein 0.0037 0.0071 0.0071
Echinococcus multilocularis Smad4 0.0032 0.0047 0.0121
Brugia malayi prolyl oligopeptidase family protein 0.0096 0.0364 0.0364
Toxoplasma gondii subtilisin SUB11 0.0063 0.0197 0.051
Mycobacterium ulcerans hypothetical protein 0.0066 0.0217 0.101
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0096 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0029 0.0028 0.0264
Echinococcus granulosus calpain A 0.019 0.0832 0.215
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0063 0.0197 0.0877
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0503 0.2999
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.2025 1 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0079 0.0278 0.0719
Echinococcus multilocularis smad 0.0032 0.0047 0.0121
Brugia malayi Kringle domain containing protein 0.0082 0.0294 0.0294
Toxoplasma gondii kringle domain-containing protein 0.0082 0.0294 0.0759
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0362 0.1691 0.4371
Mycobacterium leprae Possible secreted protease 0.0063 0.0197 0.0877
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.0047 0.0047
Toxoplasma gondii prolyl endopeptidase 0.0797 0.3869 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0234 0.1056 0.1056
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0797 0.3869 0.3869
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0096 0.0096
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.0627 0.1131
Echinococcus granulosus furin 0.0063 0.0197 0.051
Loa Loa (eye worm) hypothetical protein 0.0066 0.0217 0.0217
Brugia malayi Trypsin family protein 0.0066 0.0217 0.0217
Leishmania major hypothetical protein, conserved 0.0053 0.0151 0.0283
Trypanosoma brucei calpain-like protein, putative 0.0067 0.0219 0.0368
Loa Loa (eye worm) ctsf protein 0.0029 0.0028 0.0028
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0106 0.0414 0.0777
Leishmania major oligopeptidase b 0.0325 0.151 0.2836
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.005 0.0133 0.0133
Plasmodium vivax subtilisin-like protease 1 0.0063 0.0197 0.4966
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0031 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0106 0.0414 0.3922
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.058 0.058
Echinococcus granulosus Dipeptidyl peptidase 9 0.014 0.0586 0.1514
Onchocerca volvulus 0.0231 0.104 0.2689
Trypanosoma cruzi cysteine peptidase, putative 0.0083 0.0299 0.0512
Loa Loa (eye worm) hypothetical protein 0.005 0.0133 0.0133
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0029 0.0028 0.0072
Brugia malayi Pre-SET motif family protein 0.0029 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0246 0.1113 0.1113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0028 0.0264
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0063 0.0197 0.0197
Brugia malayi Pre-SET motif family protein 0.0203 0.09 0.09
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0096 0.0096
Loa Loa (eye worm) transcriptional regulator 0.0048 0.0126 0.0126
Trypanosoma brucei prefoldin subunit, putative 0.0068 0.0226 0.038
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0126 0.1195
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0004 0.0011
Leishmania major C-8 sterol isomerase-like protein 0.1089 0.5326 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.0047 0.0121
Brugia malayi Trypsin family protein 0.0246 0.1113 0.1113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0096 0.0096
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1089 0.5326 1
Onchocerca volvulus Deterin homolog 0.0362 0.1691 0.4371
Echinococcus granulosus chromatin regulatory protein sir2 0.0234 0.1056 0.2728
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0151 0.0239
Brugia malayi nuclear hormone receptor 0.0042 0.0096 0.0096
Echinococcus multilocularis tissue type plasminogen activator 0.0082 0.0294 0.0759
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0126 0.0126
Trypanosoma cruzi kinesin, putative 0.0047 0.0119 0.0172
Onchocerca volvulus Cathepsin L homolog 0.0029 0.0028 0.0072
Trichomonas vaginalis set domain proteins, putative 0.0231 0.104 0.9854
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0105 0.0146
Onchocerca volvulus 0.0037 0.0071 0.0184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0299 0.0519
Brugia malayi Cathepsin L-like precursor 0.0029 0.0028 0.0028
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0201 0.0201
Brugia malayi PAN domain containing protein 0.005 0.0133 0.0133
Onchocerca volvulus 0.0111 0.0437 0.113
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0028 0.0264
Loa Loa (eye worm) Smad1 0.0032 0.0047 0.0047
Entamoeba histolytica prolyl oligopeptidase family protein 0.0096 0.0364 0.3448
Onchocerca volvulus 0.0179 0.0781 0.2019
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0029 0.0727
Loa Loa (eye worm) hypothetical protein 0.0037 0.0071 0.0071
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0201 0.0518
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0096 0.0096
Mycobacterium tuberculosis Conserved protein 0.0037 0.0071 0.0209
Toxoplasma gondii subtilisin SUB1 0.0063 0.0197 0.051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0096 0.0096
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0124 0.0503 0.1483
Onchocerca volvulus 0.0037 0.0071 0.0184
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Echinococcus granulosus tissue type plasminogen activator 0.0082 0.0294 0.0759
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0217 0.0217
Echinococcus multilocularis acylamino acid releasing enzyme 0.0096 0.0364 0.0941
Loa Loa (eye worm) PAN domain-containing protein 0.005 0.0133 0.0133
Toxoplasma gondii PAN domain-containing protein 0.0331 0.1537 0.3972
Loa Loa (eye worm) hypothetical protein 0.0042 0.0096 0.0096
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0048 0.0126 0.1195
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0243 0.0243
Leishmania major cathepsin L-like protease 0.0029 0.0028 0.0052
Schistosoma mansoni Mername-AA248 (C02 family) 0.0067 0.0219 0.0219
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0096 0.0247
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0356 0.0921
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0151 0.0391
Toxoplasma gondii 1,3(4)-beta-glucanase 0.005 0.0133 0.0343
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.058 0.15
Brugia malayi Cathepsin L-like precursor 0.0029 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0042 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0049 0.0132 0.0132
Onchocerca volvulus 0.0066 0.0217 0.056
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0362 0.1691 0.1691
Brugia malayi MH1 domain containing protein 0.0032 0.0047 0.0047
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0124 0.0503 0.0944
Brugia malayi Ets-domain containing protein 0.0078 0.0276 0.0276
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0251 0.1141 0.2949
Schistosoma mansoni hypothetical protein 0.0297 0.1371 0.1371
Trypanosoma brucei calpain-like protein, putative 0.0067 0.0219 0.0368
Giardia lamblia Hypothetical protein 0.0068 0.0226 0.1916
Leishmania major sir2-family protein-like protein 0.0048 0.0126 0.0237
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0071 0.0673
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0031 0.0079
Brugia malayi Trypsin family protein 0.0066 0.0217 0.0217
Toxoplasma gondii subtilisin SUB4 0.0063 0.0197 0.051
Toxoplasma gondii PAN domain-containing protein 0.005 0.0133 0.0343
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0219 0.0361
Toxoplasma gondii microneme protein MIC17A 0.005 0.0133 0.0343
Brugia malayi MH2 domain containing protein 0.0476 0.2264 0.2264
Plasmodium vivax SET domain protein, putative 0.0029 0.0031 0.0769
Echinococcus multilocularis neuroendocrine convertase 2 0.0063 0.0197 0.051
Onchocerca volvulus Cathepsin L homolog 0.0029 0.0028 0.0072
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0067 0.0219 0.0368
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0314 0.1453 0.2695
Echinococcus multilocularis calpain 5 0.0067 0.0219 0.0567
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0024 0.0062
Leishmania major kinesin, putative 0.0047 0.0119 0.0223
Onchocerca volvulus 0.005 0.0133 0.0343
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0096 0.0096
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0063 0.0197 0.0197
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0096 0.0096
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0029 0.0075
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0067 0.0219 0.0361
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.0627 0.1177
Plasmodium vivax vivapain-2 0.0029 0.0028 0.0704
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0096 0.0247
Plasmodium vivax NAD-dependent deacetylase, putative 0.0048 0.0126 0.3177
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0061 0.019 0.1796
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0059 0.0153
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0028 0.0264
Onchocerca volvulus 0.005 0.0133 0.0343
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0048 0.0126 0.0326
Echinococcus granulosus survival motor neuron protein 1 0.05 0.2384 0.6162
Plasmodium falciparum multidrug resistance protein 1 0.0023 0 0.0004
Echinococcus multilocularis Mastin 0.0066 0.0217 0.0559
Trypanosoma cruzi prolyl endopeptidase 0.0797 0.3869 0.725
Echinococcus granulosus Furin 1 0.0063 0.0197 0.051
Brugia malayi MH2 domain containing protein 0.0032 0.0047 0.0047
Toxoplasma gondii PAN/Apple domain-containing protein 0.005 0.0133 0.0343
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0126 0.0126
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0151 0.3801
Echinococcus multilocularis membrane bound transcription factor site 1 0.0063 0.0197 0.051
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0028
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0155 0.0658 0.1699
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0067 0.0219 0.0361
Onchocerca volvulus 0.0029 0.0028 0.0072
Trypanosoma brucei calpain-like protein, putative 0.0067 0.0219 0.0368
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0061 0.019 0.049
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.058 0.15
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0151 0.3801
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0066 0.0217 0.0559
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0217 0.0217
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0067 0.0219 0.0361
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0071 0.0184
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0085 0.022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0028 0.0264
Trypanosoma brucei C-8 sterol isomerase, putative 0.1089 0.5326 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0416 0.0416
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.014 0.0586 0.1053
Toxoplasma gondii histone deacetylase SIR2 0.0048 0.0126 0.0326
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Brugia malayi steroid hormone receptor 0.0042 0.0096 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0096 0.0096
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0503 0.2999
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0028 0.0264
Echinococcus multilocularis calpain 0.0067 0.0219 0.0567
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0251 0.1141 0.2949
Schistosoma mansoni ets-related 0.0238 0.1073 0.1073
Echinococcus multilocularis geminin 0.0338 0.1575 0.407
Echinococcus granulosus importin subunit beta 1 0.0028 0.0024 0.0062
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0126 0.1195
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0029 0.0075
Mycobacterium ulcerans NAD-dependent deacetylase 0.0048 0.0126 0.0383
Giardia lamblia Cathepsin B precursor 0.0106 0.0414 0.3752
Schistosoma mansoni calpain C (C02 family) 0.0067 0.0219 0.0219
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0362 0.1691 0.4371
Giardia lamblia Alanyl dipeptidyl peptidase 0.0096 0.0364 0.3264
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0028 0.0264
Trypanosoma cruzi prefoldin subunit, putative 0.0068 0.0226 0.0373
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0096 0.0096
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0314 0.1452 0.1452
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0278 0.2633
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.058 0.058
Plasmodium falciparum plasmepsin I 0.0061 0.019 0.4774
Loa Loa (eye worm) hypothetical protein 0.0042 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0155 0.0658 0.0658
Echinococcus multilocularis prefoldin subunit 6 0.0068 0.0226 0.0583
Echinococcus granulosus Mastin 0.0066 0.0217 0.0559
Trypanosoma brucei SIR2-like protein 4, putative 0.0048 0.0126 0.0193
Brugia malayi Ets-domain containing protein 0.0078 0.0276 0.0276
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.0047 0.0047
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0234 0.1056 0.194
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0063 0.0197 0.0582
Toxoplasma gondii subtilisin SUB6 0.0063 0.0197 0.051
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0096 0.0096
Echinococcus multilocularis cysteine protease 0.0029 0.0028 0.0072
Onchocerca volvulus 0.0102 0.0395 0.102
Echinococcus granulosus cathepsin l1 0.0029 0.0028 0.0072
Schistosoma mansoni cathepsin F (C01 family) 0.0029 0.0028 0.0028
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.005 0.0133 0.0133
Brugia malayi PAN domain containing protein 0.005 0.0133 0.0133
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0071 0.0081
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.014 0.0586 0.106
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0028 0.0264
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0702 0.339 1
Schistosoma mansoni calpain-7 (C02 family) 0.0067 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.1089 0.5326 0.5326
Onchocerca volvulus 0.005 0.0133 0.0343
Brugia malayi hypothetical protein 0.0066 0.0217 0.0217
Onchocerca volvulus 0.005 0.0133 0.0343
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0031
Brugia malayi ecdysteroid receptor 0.0042 0.0096 0.0096
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1089 0.5326 0.5326
Trichomonas vaginalis esterase, putative 0.0037 0.0071 0.0673
Brugia malayi hypothetical protein 0.01 0.0385 0.0385
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0246 0.1113 0.1113
Loa Loa (eye worm) hypothetical protein 0.01 0.0385 0.0385
Loa Loa (eye worm) hypothetical protein 0.0061 0.019 0.019
Leishmania major cathepsin L-like protease 0.0029 0.0028 0.0052
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0028 0.0264
Echinococcus multilocularis calpain A 0.019 0.0832 0.215
Loa Loa (eye worm) hypothetical protein 0.0157 0.0671 0.0671
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0059 0.0059
Toxoplasma gondii subtilisin SUB9 0.0063 0.0197 0.051
Loa Loa (eye worm) prolyl oligopeptidase 0.0096 0.0364 0.0364
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0234 0.1056 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.007 0.0237 0.0698
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0071 0.0184
Loa Loa (eye worm) hypothetical protein 0.0037 0.0071 0.0071
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0048 0.0126 0.3177
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0066 0.0217 0.0559
Plasmodium falciparum prefoldin subunit 6, putative 0.0068 0.0226 0.5678
Plasmodium vivax multidrug resistance protein 1, putative 0.0023 0 0.0004
Loa Loa (eye worm) hypothetical protein 0.0067 0.022 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0364 0.3448
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0066 0.0217 0.0217
Echinococcus multilocularis snurportin 1 0.0297 0.1371 0.3542
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0028 0.0264
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0217 0.0217
Brugia malayi prolyl oligopeptidase family protein 0.0096 0.0364 0.0364
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0096 0.0247
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0066 0.0217 0.0559
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0314 0.1452 0.1452
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0063 0.0197 0.051
Brugia malayi KE2 family protein 0.0068 0.0226 0.0226
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0096 0.0096
Echinococcus multilocularis cathepsin L cysteine protease 0.0029 0.0028 0.0072
Brugia malayi RNA, U transporter 1 0.0079 0.0281 0.0281
Giardia lamblia Hypothetical protein 0.0234 0.1056 1
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0234 0.1056 0.1946
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0259 0.0259
Toxoplasma gondii microneme protein, putative 0.005 0.0133 0.0343
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Brugia malayi Fli-1 protein 0.0238 0.1073 0.1073
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.1371 0.1371
Leishmania major cathepsin L-like protease 0.0083 0.0299 0.0562
Echinococcus multilocularis prolyl endopeptidase 0.0797 0.3869 1
Echinococcus multilocularis 0.0063 0.0197 0.051
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0061 0.019 0.019
Echinococcus multilocularis cathepsin b 0.0314 0.1452 0.3754
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.007 0.0237 0.1151
Entamoeba histolytica hypothetical protein 0.0072 0.0243 0.2305
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0063 0.0197 0.0582
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0126 0.1195
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0028 0.0264
Echinococcus multilocularis cathepsin L cysteine protease 0.0029 0.0028 0.0072
Trypanosoma cruzi cysteine peptidase, putative 0.0083 0.0299 0.0512
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0048 0.0126 0.0372
Onchocerca volvulus 0.005 0.0133 0.0343
Schistosoma mansoni cathepsin F (C01 family) 0.0029 0.0028 0.0028
Leishmania major prefoldin subunit, putative 0.0068 0.0226 0.0423
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0503 0.0503
Echinococcus multilocularis cysteine protease 0.0029 0.0028 0.0072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0299 0.0519
Brugia malayi prolyl oligopeptidase family protein 0.0797 0.3869 0.3869
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0219 0.0361
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0077 0.0267 0.0452
Loa Loa (eye worm) calpain family protein 1 0.0131 0.0538 0.0538
Schistosoma mansoni survival motor neuron protein 0.0102 0.0395 0.0395
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0063 0.0197 0.0582
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0189 0.0831 0.0831
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0028 0.0264
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0096 0.0247
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0314 0.1452 0.2689
Brugia malayi Cathepsin L-like precursor 0.0029 0.0028 0.0028
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0255 0.1159 0.2996
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0066 0.0217 0.0217
Schistosoma mansoni cathepsin D (A01 family) 0.0251 0.1138 0.1138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0028 0.0264
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0201 0.0201
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0096 0.0247
Schistosoma mansoni coup transcription factor 0.0042 0.0096 0.0096
Plasmodium vivax importin-beta 2, putative 0.0028 0.0024 0.0607
Onchocerca volvulus 0.0246 0.1113 0.2876
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0029 0.0028 0.0704
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0189 0.0831 0.2147
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0362 0.1691 0.1691
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.058 0.058
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0105 0.0146
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.09 0.09
Toxoplasma gondii PAN domain-containing protein 0.005 0.0133 0.0343
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Loa Loa (eye worm) sirtuin 4 0.0048 0.0126 0.0126
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0155 0.0658 0.1699
Schistosoma mansoni smad1 5 8 and 0.0032 0.0047 0.0047
Brugia malayi PAN domain containing protein 0.005 0.0133 0.0133
Leishmania major hypothetical protein, conserved 0.0082 0.0294 0.0551
Brugia malayi Cathepsin L-like precursor 0.0029 0.0028 0.0028
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0063 0.0197 0.032
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0096 0.0096
Trypanosoma cruzi kinesin, putative 0.0047 0.0119 0.0172
Loa Loa (eye worm) hypothetical protein 0.0044 0.0107 0.0107
Loa Loa (eye worm) proprotein convertase 2 0.0063 0.0197 0.0197
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0079 0.0278 0.2633
Echinococcus multilocularis Dipeptidyl peptidase 9 0.014 0.0586 0.1514
Entamoeba histolytica hypothetical protein 0.0072 0.0243 0.2305
Loa Loa (eye worm) PAN domain-containing protein 0.005 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0042 0.0096 0.0096
Brugia malayi PAN domain containing protein 0.005 0.0133 0.0133
Trypanosoma cruzi hypothetical protein, conserved 0.0096 0.0364 0.0634
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0155 0.0658 0.6228
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0096 0.0247
Trypanosoma cruzi oligopeptidase b 0.0325 0.151 0.2798
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0031 0.0031
Plasmodium falciparum subtilisin-like protease 3 0.0063 0.0197 0.4966
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0151 0.0232
Plasmodium falciparum plasmepsin IV 0.0061 0.019 0.4774
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0029 0.0074
Schistosoma mansoni chromatin regulatory protein sir2 0.0234 0.1056 0.1056
Brugia malayi Protein kinase domain containing protein 0.0082 0.0294 0.0294
Echinococcus granulosus jumonji domain containing protein 0.004 0.0085 0.022
Brugia malayi MH2 domain containing protein 0.0032 0.0047 0.0047
Brugia malayi hypothetical protein 0.0053 0.0151 0.0151
Onchocerca volvulus 0.0066 0.0217 0.056
Toxoplasma gondii ABC1 family protein 0.0037 0.0071 0.0184
Mycobacterium tuberculosis Conserved protein 0.0037 0.0071 0.0209
Leishmania major cathepsin L-like protease 0.0029 0.0028 0.0052
Brugia malayi proprotein convertase 2 0.0063 0.0197 0.0197
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0096 0.0247
Plasmodium vivax hypothetical protein, conserved 0.0096 0.0364 0.916
Echinococcus granulosus transmembrane protease serine 3 0.0066 0.0217 0.0559
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0048 0.0126 0.1195
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0063 0.0197 0.0197
Brugia malayi Trypsin family protein 0.0066 0.0217 0.0217
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0063 0.0197 0.0197
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0096 0.0247
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0066 0.0217 0.0217
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0048 0.0126 0.0326
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0096 0.0247
Plasmodium falciparum importin beta, putative 0.0028 0.0024 0.0607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0299 0.0519
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0028 0.0264
Schistosoma mansoni hypothetical protein 0.0082 0.0294 0.0294
Trichomonas vaginalis inositol monophosphatase, putative 0.0079 0.0278 0.2633
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0029 0.0028 0.0028
Toxoplasma gondii cathepsin B 0.0106 0.0414 0.107
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0096 0.0096
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0096 0.0096
Plasmodium falciparum plasmepsin IX 0.0103 0.0397 1
Echinococcus granulosus prefoldin subunit 6 0.0068 0.0226 0.0583
Schistosoma mansoni hypothetical protein 0.01 0.0385 0.0385
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0028 0.0264
Schistosoma mansoni hypothetical protein 0.0338 0.1575 0.1575
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0067 0.0219 0.0361
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.0047 0.0121
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0063 0.0197 0.0327
Loa Loa (eye worm) hypothetical protein 0.0066 0.0217 0.0217
Loa Loa (eye worm) endoprotease bli-4 0.0063 0.0197 0.0197
Loa Loa (eye worm) TK/ROR protein kinase 0.0082 0.0294 0.0294
Schistosoma mansoni caspase-7 (C14 family) 0.01 0.0385 0.0385
Giardia lamblia Transcriptional regulator, Sir2 family 0.0048 0.0126 0.0948
Loa Loa (eye worm) hypothetical protein 0.0037 0.0071 0.0071
Toxoplasma gondii hypothetical protein 0.0096 0.0364 0.0941
Trypanosoma brucei oligopeptidase b 0.0325 0.151 0.2804
Echinococcus granulosus enteropeptidase 0.0066 0.0217 0.0559
Schistosoma mansoni chromatin regulatory protein sir2 0.0155 0.0658 0.0658
Trypanosoma cruzi oligopeptidase b 0.0325 0.151 0.2798
Schistosoma mansoni calpain-7 (C02 family) 0.0067 0.0219 0.0219
Loa Loa (eye worm) fibroinase 0.0029 0.0028 0.0028
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0096 0.0096
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0071 0.0081
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.0711 0.2096
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0096 0.0096
Loa Loa (eye worm) cysteine protease 0.0029 0.0028 0.0028
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0048 0.0126 0.0193
Trypanosoma cruzi cysteine peptidase, putative 0.0083 0.0299 0.0512
Toxoplasma gondii aspartyl protease ASP3 0.0103 0.0397 0.1027
Brugia malayi Cathepsin L-like precursor 0.0029 0.0028 0.0028
Leishmania major subtilisin-like serine peptidase 0.0063 0.0197 0.037
Onchocerca volvulus Cathepsin F homolog 0.0029 0.0028 0.0072
Loa Loa (eye worm) hypothetical protein 0.0042 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0042 0.0096 0.0096
Schistosoma mansoni site-1 peptidase (S08 family) 0.0063 0.0197 0.0197
Trypanosoma brucei calpain-like protein, putative 0.0067 0.0219 0.0368
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0028 0.0264
Onchocerca volvulus 0.0029 0.0028 0.0072
Giardia lamblia Cathepsin B precursor 0.0106 0.0414 0.3752
Trypanosoma brucei cysteine peptidase C (CPC) 0.0106 0.0414 0.0736
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.058 0.058
Toxoplasma gondii subtilisin SUB12 0.0112 0.0445 0.115
Schistosoma mansoni hypothetical protein 0.0024 0.0004 0.0004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Entamoeba histolytica protein kinase, putative 0.0047 0.0119 0.1125
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0071 0.0071
Giardia lamblia Sirtuin type 2 0.0048 0.0126 0.0948
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0096 0.0096
Brugia malayi endoprotease bli-4 precursor 0.0063 0.0197 0.0197
Plasmodium vivax aspartyl proteinase, putative 0.0061 0.019 0.4774
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.0047 0.0121
Brugia malayi beta-lactamase 0.0037 0.0071 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0219 0.0368
Brugia malayi RNA binding protein 0.0063 0.0201 0.0201
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0126 0.1195
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0071 0.0209
Schistosoma mansoni inositol monophosphatase 0.0079 0.0278 0.0278
Brugia malayi hypothetical protein 0.0072 0.0243 0.0243
Echinococcus multilocularis survival motor neuron protein 1 0.05 0.2384 0.6162
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0071 0.0673
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0096 0.0364 0.0641
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0189 0.0831 0.2147
Loa Loa (eye worm) hypothetical protein 0.0066 0.0217 0.0217
Toxoplasma gondii microneme protein MIC4 0.005 0.0133 0.0343
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0028 0.0264
Echinococcus granulosus tar DNA binding protein 0.0063 0.0201 0.0518
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0278 0.0472
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0067 0.0219 0.0361
Echinococcus granulosus acylamino acid releasing enzyme 0.0096 0.0364 0.0941
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0079 0.0278 0.1437
Loa Loa (eye worm) hypothetical protein 0.0131 0.0538 0.0538
Toxoplasma gondii microneme protein MIC17B 0.005 0.0133 0.0343
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0048 0.0126 0.3177
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0063 0.0197 0.051
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0096 0.0096
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0071 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0028 0.0264
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0096 0.0096
Trypanosoma brucei kinesin, putative 0.0047 0.0119 0.0179
Brugia malayi PAN domain containing protein 0.005 0.0133 0.0133
Brugia malayi Smad1 0.0032 0.0047 0.0047
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Mycobacterium tuberculosis Probable peptidase 0.0325 0.151 0.4456
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.014 0.0586 0.11
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0063 0.0197 0.0582
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0177 0.0772 0.0772
Brugia malayi calpain family protein 1 0.0177 0.0772 0.0772
Echinococcus multilocularis Furin 1 0.0063 0.0197 0.051
Toxoplasma gondii hypothetical protein 0.0051 0.0138 0.0356
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.014 0.0586 0.1515
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0299 0.0519
Plasmodium falciparum phd finger protein, putative 0.0029 0.0029 0.0727
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.058 0.15
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0096 0.0247
Loa Loa (eye worm) transcription factor SMAD2 0.0476 0.2264 0.2264
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0797 0.3869 0.3869
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0503 0.2999
Toxoplasma gondii microneme protein MIC17C 0.005 0.0133 0.0343
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0029 0.0028 0.0264
Brugia malayi jmjC domain containing protein 0.0035 0.0059 0.0059
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0234 0.1056 1
Schistosoma mansoni hypothetical protein 0.0029 0.0029 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0201 0.0201
Onchocerca volvulus 0.0362 0.1691 0.4371
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0071 0.0209
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0059 0.0153
Brugia malayi Inositol-1 0.0079 0.0278 0.0278
Onchocerca volvulus 0.0029 0.0028 0.0072
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0029 0.0028 0.0072
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0029 0.0028 0.0704
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0219 0.0412
Echinococcus granulosus inositol monophosphatase 1 0.0079 0.0278 0.0718
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0106 0.0414 0.0414
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0096 0.0096
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0217 0.0217
Plasmodium falciparum subtilisin-like protease 2 0.0063 0.0197 0.4966
Brugia malayi PAN domain containing protein 0.005 0.0133 0.0133
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0042 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.005 0.0133 0.0133
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0096 0.0247
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0325 0.151 0.4456
Plasmodium vivax plasmepsin IV, putative 0.0061 0.019 0.4774
Brugia malayi Cathepsin L-like precursor 0.0029 0.0028 0.0028
Mycobacterium ulcerans hypothetical protein 0.0165 0.0711 0.4444
Loa Loa (eye worm) hypothetical protein 0.0063 0.0197 0.0197
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0066 0.0217 0.0217
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0063 0.0197 0.1868
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0155 0.0658 0.6228
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0028 0.0028
Toxoplasma gondii subtilisin SUB5 0.0063 0.0197 0.051
Plasmodium falciparum subtilisin-like protease 1 0.0063 0.0197 0.4966
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0234 0.1056 0.2728
Echinococcus multilocularis chromatin regulatory protein sir2 0.0234 0.1056 0.2728
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0255 0.1159 0.2996
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.1453 0.2689
Schistosoma mansoni smad 0.0032 0.0047 0.0047
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0219 0.0412
Toxoplasma gondii prefoldin subunit 6, putative 0.0068 0.0226 0.0583
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0106 0.0414 0.0729
Echinococcus multilocularis transmembrane protease serine 3 0.0066 0.0217 0.0559
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0096 0.0364 0.0364
Echinococcus granulosus snurportin 1 0.0297 0.1371 0.3542
Schistosoma mansoni smad1 5 8 and 0.0032 0.0047 0.0047
Toxoplasma gondii PAN domain-containing protein 0.0331 0.1537 0.3972
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0299 0.0519
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0096 0.0096
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0071 0.0089
Leishmania major cathepsin L-like protease 0.0029 0.0028 0.0052
Loa Loa (eye worm) calpain family protein 1 0.0177 0.0772 0.0772
Toxoplasma gondii histone deacetylase SIR2-like 0.0048 0.0126 0.0326
Echinococcus granulosus Smad4 0.0032 0.0047 0.0121
Loa Loa (eye worm) PAN domain-containing protein 0.005 0.0133 0.0133
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0048 0.0126 0.0326
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0028 0.0264
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0096 0.0247
Brugia malayi PAN domain containing protein 0.005 0.0133 0.0133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0096 0.0096
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0155 0.0658 0.6123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0028 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0197 0.1868
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0029 0.0029
Trypanosoma brucei prolyl oligopeptidase, putative 0.0325 0.151 0.2804
Schistosoma mansoni inhibitor of apoptosis protein 0.0362 0.1691 0.1691
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0149 0.0627 0.1137
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0096 0.0247
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0061 0.019 0.019
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0067 0.0219 0.0361
Loa Loa (eye worm) hypothetical protein 0.0063 0.0197 0.0197
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0201 0.0201
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0031 0.0031
Toxoplasma gondii subtilisin SUB2 0.0063 0.0197 0.051
Schistosoma mansoni calpain (C02 family) 0.0067 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0024
Brugia malayi PHD-finger family protein 0.0029 0.0029 0.0029
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0234 0.1056 0.2728
Brugia malayi transcriptional regulator, Sir2 family protein 0.0048 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0068 0.0226 0.0226
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0066 0.0217 0.0217
Leishmania major silent information regulator 2, putative 0.0234 0.1056 0.1982
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0063 0.0197 0.032
Echinococcus granulosus geminin 0.0338 0.1575 0.407
Onchocerca volvulus 0.005 0.0133 0.0343
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0126 0.1195
Schistosoma mansoni chromatin regulatory protein sir2 0.0234 0.1056 0.1056
Leishmania major cathepsin L-like protease 0.0083 0.0299 0.0562
Onchocerca volvulus 0.0066 0.0217 0.056
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.014 0.0586 0.106
Loa Loa (eye worm) transcriptional regulator 0.0234 0.1056 0.1056
Echinococcus granulosus calpain A 0.0067 0.0219 0.0567
Onchocerca volvulus 0.0029 0.0028 0.0072
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0048 0.0126 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0197 0.1868
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0758 0.3672 0.9492
Loa Loa (eye worm) fli-1 protein 0.0238 0.1073 0.1073
Echinococcus granulosus apoptotic protease activating factor 1 0.01 0.0385 0.0994
Brugia malayi calpain 5 0.0047 0.0119 0.0119
Entamoeba histolytica hypothetical protein 0.0072 0.0243 0.2305
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0031 0.0031
Plasmodium vivax prefoldin subunit 6, putative 0.0068 0.0226 0.5678
Brugia malayi nuclear receptor NHR-88 0.0042 0.0096 0.0096
Brugia malayi Cell death protein 3 precursor 0.01 0.0385 0.0385
Echinococcus multilocularis cathepsin b 0.0314 0.1452 0.3754
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0071 0.0209
Loa Loa (eye worm) MH2 domain-containing protein 0.0476 0.2264 0.2264
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0217 0.0217
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0797 0.3869 0.3869
Brugia malayi hypothetical protein 0.05 0.2384 0.2384
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0234 0.1056 0.194
Loa Loa (eye worm) hypothetical protein 0.0177 0.0772 0.0772
Loa Loa (eye worm) cathepsin B 0.0106 0.0414 0.0414
Onchocerca volvulus 0.0037 0.0071 0.0184
Leishmania major cathepsin L-like protease 0.0029 0.0028 0.0052
Onchocerca volvulus 0.005 0.0133 0.0343
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0029 0.0028 0.0028
Trypanosoma cruzi subtilisin peptidase 0.0063 0.0197 0.032
Trypanosoma brucei antigen, putative 0.0067 0.0219 0.0368
Plasmodium falciparum plasmepsin II 0.0061 0.019 0.4774
Brugia malayi jmjC domain containing protein 0.0094 0.0356 0.0356
Echinococcus granulosus glycoprotein Antigen 5 0.0066 0.0217 0.0559
Toxoplasma gondii PAN domain-containing protein 0.005 0.0133 0.0343
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.0299 0.0519
Schistosoma mansoni gabp alpha 0.0078 0.0276 0.0276
Echinococcus granulosus smad 0.0032 0.0047 0.0121
Echinococcus granulosus calpain 5 0.0067 0.0219 0.0567
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.1074 0.3169
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0004 0.0011
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0278 0.0472
Echinococcus granulosus cathepsin b 0.0314 0.1452 0.3754
Echinococcus multilocularis caspase 2 0.01 0.0385 0.0994
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0325 0.151 0.2804
Schistosoma mansoni site-1 peptidase (S08 family) 0.0063 0.0197 0.0197
Brugia malayi transcriptional regulator, Sir2 family protein 0.0048 0.0126 0.0126

Activities

Activity type Activity value Assay description Source Reference
T/C (functional) = 0 % Antitumor activity of the compound against P388, was determined by injecting intraperitoneally in mice, at a dose of 20 mg/kg ChEMBL. 3806570
T/C (functional) = 0 % Antitumor activity of the compound against P388, was determined by injecting intraperitoneally in mice, at a dose of 10 mg/kg ChEMBL. 3806570
T/C (functional) = 0 % Antitumor activity of the compound against P388, was determined by injecting intraperitoneally in mice, at a dose of 20 mg/kg ChEMBL. 3806570
T/C (functional) = 0 % Antitumor activity of the compound against P388, was determined by injecting intraperitoneally in mice, at a dose of 10 mg/kg ChEMBL. 3806570
T/C (functional) = 125 % Antitumor activity in P388 innoculated mice following 5 mg/kg i.p. administration. ChEMBL. 3806570
T/C (functional) = 125 % Antitumor activity in P388 innoculated mice following 5 mg/kg i.p. administration. ChEMBL. 3806570

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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