Detailed information for compound 223833

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 440.248 | Formula: C20H15Cl2F2N2O3-
  • H donors: 2 H acceptors: 3 LogP: 5.65 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)NCc1c(F)cc2c(c1F)n(cc(c2=O)C(=O)O)C1CC1.[Cl-]
  • InChi: 1S/C20H15ClF2N2O3.ClH/c21-10-2-1-3-11(6-10)24-8-14-16(22)7-13-18(17(14)23)25(12-4-5-12)9-15(19(13)26)20(27)28;/h1-3,6-7,9,12,24H,4-5,8H2,(H,27,28);1H/p-1
  • InChiKey: SKVOFYIQLRAHHD-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.002 0.0133 0.0234
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0123 0.0178
Brugia malayi Smad1 0.0042 0.0383 0.0563
Loa Loa (eye worm) nuclear factor I 0.0023 0.0173 0.0249
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3241 0.5996
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0383 0.049
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.008 0.0095
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0115
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0192
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0266 0.0259
Trypanosoma cruzi aldo/keto reductase, putative 0.0042 0.0379 0.2389
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0094 0.0087
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0123 0.1287 0.8181
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.1001 0.1297
Brugia malayi Integrin alpha pat-2 precursor 0.0062 0.0605 0.089
Plasmodium falciparum aldo-keto reductase, putative 0.0042 0.0379 0.6501
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0246 0.1499
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0811 0.1193
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0012 0.0044 0.042
Trichomonas vaginalis aldo-keto reductase, putative 0.0144 0.1521 0.2806
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0067
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.002 0.0133 0.0126
Schistosoma mansoni methylthioadenosine phosphorylase 0.0026 0.0198 0.0249
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0047 0.0069
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0153 0.019
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0015 0.0022
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0144 0.1521 0.1975
Schistosoma mansoni hypothetical protein 0.0081 0.0811 0.1049
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0192
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0009 0.0015 0.0022
Echinococcus multilocularis neuropeptide receptor A26 0.0473 0.5178 0.5175
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0153 0.0881
Schistosoma mansoni acetylcholine receptor subunit beta 0.0009 0.0015 0.001
Plasmodium vivax SET domain protein, putative 0.0063 0.0612 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0011 0.0032 0.0047
Schistosoma mansoni nAChR subunit 0.002 0.0133 0.0164
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.1287 0.167
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0133 0.0126
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0448 0.0817
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.008 0.0115
Echinococcus multilocularis phd:f box containing protein 0.001 0.0021 0.0014
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0094 0.0485
Loa Loa (eye worm) hypothetical protein 0.0032 0.0266 0.0383
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0046
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0009 0.0015 0.001
Schistosoma mansoni DNA polymerase eta 0.0021 0.0153 0.019
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0022
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0271 0.039
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0026 0.0198 0.1182
Trypanosoma brucei unspecified product 0.0015 0.0079 0.0386
Trypanosoma brucei unspecified product 0.0021 0.0153 0.0881
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0266 0.0338
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0042 0.0379 0.6061
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0398 0.051
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0078 0.0778 0.2383
Loa Loa (eye worm) hypothetical protein 0.0019 0.0123 0.0178
Schistosoma mansoni acetylcholine receptor-related 0.0009 0.0015 0.001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0266 0.0383
Onchocerca volvulus 0.0014 0.0075 0.0125
Echinococcus granulosus nAChR subunit 0.002 0.0133 0.0164
Brugia malayi hypothetical protein 0.0017 0.01 0.0147
Loa Loa (eye worm) MH2 domain-containing protein 0.0618 0.6796 0.979
Trypanosoma cruzi aldo/keto reductase, putative 0.0144 0.1521 1
Echinococcus granulosus Smad4 0.0042 0.0383 0.049
Schistosoma mansoni Smad4 0.0042 0.0383 0.049
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0266 0.0392
Plasmodium vivax transportin, putative 0.0011 0.0038 0.0294
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.018 0.0194
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0047 0.0171
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0266 0.0392
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0153 0.0881
Loa Loa (eye worm) integrin alpha pat-2 0.0137 0.1439 0.2073
Echinococcus granulosus lamin dm0 0.0014 0.0075 0.0088
Onchocerca volvulus 0.0009 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0059 0.0572 0.0824
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0009 0.0015 0.0022
Schistosoma mansoni smad 0.0019 0.0123 0.0152
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0778 0.5048
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0336 0.0484
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.002 0.0133 0.0164
Trichomonas vaginalis aldo-keto reductase, putative 0.0144 0.1521 0.2806
Brugia malayi Cation transporter family protein 0.002 0.0133 0.0196
Brugia malayi jmjC domain containing protein 0.001 0.0021 0.0031
Brugia malayi Importin beta-1 subunit 0.0059 0.0572 0.0842
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0022 0.0009
Schistosoma mansoni nAChR subunit 0.002 0.0133 0.0164
Trichomonas vaginalis hypothetical protein 0.0011 0.0038 0.0058
Onchocerca volvulus Alhambra homolog 0.003 0.0246 0.0442
Brugia malayi ecdysteroid receptor 0.0032 0.0266 0.0392
Brugia malayi hypothetical protein 0.0009 0.0015 0.0022
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.008 0.0095
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0572 0.3675
Echinococcus multilocularis purine nucleoside phosphorylase 0.0123 0.1287 0.1281
Brugia malayi hypothetical protein 0.0009 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0174 0.1852 0.2668
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0015 0.0022
Loa Loa (eye worm) Smad1 0.0042 0.0383 0.0551
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0246 0.0354
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0195 0.2087 0.2714
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0144 0.1521 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0192 0.1143
Echinococcus granulosus lysine specific demethylase 6a 0.001 0.0021 0.0018
Trichomonas vaginalis aldo-keto reductase, putative 0.0144 0.1521 0.2806
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0266 0.0392
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0153 0.0146
Loa Loa (eye worm) hypothetical protein 0.0032 0.0266 0.0383
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0144 0.1521 0.1975
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0046
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0011 0.0032 0.0047
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0433 0.4735 0.6822
Brugia malayi hypothetical protein 0.0009 0.0015 0.0022
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.008 0.0135
Brugia malayi Nuclear hormone receptor E75 0.0015 0.008 0.0118
Brugia malayi MH2 domain containing protein 0.0019 0.0123 0.0182
Brugia malayi Pre-SET motif family protein 0.0063 0.0612 0.0901
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0455 0.2895
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0061
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.1287 0.167
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0198 0.0354
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.008 0.0115
Loa Loa (eye worm) hypothetical protein 0.0063 0.0612 0.0882
Trypanosoma brucei aldo-keto reductase, putative 0.0144 0.1521 1
Brugia malayi PHD-finger family protein 0.0012 0.0043 0.0063
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.002 0.0133 0.0196
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0009 0.0015 0.001
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0019 0.0123 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0266 0.0392
Onchocerca volvulus 0.0063 0.0612 0.1122
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0379 0.069
Loa Loa (eye worm) hypothetical protein 0.0032 0.0266 0.0383
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0153 0.0881
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0026 0.0198 0.0475
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0266 0.0259
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0383 0.0551
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0612 0.0789
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.008 0.0073
Schistosoma mansoni cpg binding protein 0.0032 0.0271 0.0344
Echinococcus multilocularis purine nucleoside phosphorylase 0.0123 0.1287 0.1281
Schistosoma mansoni hypothetical protein 0.0081 0.0811 0.1049
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.086 0.1113
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0022 0.0009
Plasmodium falciparum phd finger protein, putative 0.003 0.0246 0.4078
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0572 0.3675
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0032 0.0273 0.0394
Trichomonas vaginalis ran, putative 0.0044 0.0398 0.0725
Echinococcus multilocularis cpg binding protein 0.0034 0.0291 0.0284
Echinococcus multilocularis lysine specific demethylase 6a 0.001 0.0021 0.0014
Echinococcus granulosus phd:f box containing protein 0.001 0.0021 0.0018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0153 0.0221
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0047 0.0073
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.002 0.0133 0.0164
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0022
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0026 0.0198 0.1182
Brugia malayi nuclear receptor NHR-67 0.0015 0.008 0.0118
Trichomonas vaginalis DNA helicase recq1, putative 0.0012 0.0047 0.0073
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0047 0.0069
Echinococcus granulosus integrin alpha 3 0.003 0.0245 0.031
Echinococcus granulosus voltage gated potassium channel subunit 0.0042 0.0379 0.0485
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0195 0.2087 0.2714
Echinococcus multilocularis translational activator gcn1 0.0011 0.0038 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0612 0.0789
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0153 0.0221
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0144 0.1521 0.2806
Schistosoma mansoni ran 0.0044 0.0398 0.051
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0026 0.0198 0.0591
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0022
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0627 0.0808
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0398 0.0574
Entamoeba histolytica Ran family GTPase 0.0044 0.0398 0.1209
Echinococcus multilocularis bloom syndrome protein 0.0012 0.0047 0.0039
Brugia malayi hypothetical protein 0.0017 0.01 0.0147
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0266 0.048
Onchocerca volvulus 0.0032 0.0271 0.0489
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3241 0.5996
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0153 0.0881
Trichomonas vaginalis aldo-keto reductase, putative 0.0144 0.1521 0.2806
Trichomonas vaginalis aldo-keto reductase, putative 0.0144 0.1521 0.2806
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0784 0.1013
Loa Loa (eye worm) hypothetical protein 0.0008 0.0007 0.001
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.008 0.0095
Trichomonas vaginalis aldo-keto reductase, putative 0.0144 0.1521 0.2806
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.008 0.0118
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.002 0.0133 0.0164
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0026 0.0198 0.0591
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0455 0.2895
Loa Loa (eye worm) hypothetical protein 0.0008 0.0007 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3241 0.5996
Schistosoma mansoni hypothetical protein 0.0174 0.1852 0.2407
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0266 0.0259
Toxoplasma gondii aldose reductase, putative 0.0144 0.1521 1
Echinococcus multilocularis aldo keto reductase 0.0144 0.1521 0.1514
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0192
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0133 0.0164
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.008 0.0095
Loa Loa (eye worm) hypothetical protein 0.0014 0.0072 0.0103
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3241 0.5996
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0136 0.0169
Echinococcus granulosus JmjC domain containing protein 4 0.001 0.0021 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0192
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0266 0.0338
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.041 0.1138
Brugia malayi MH1 domain containing protein 0.0023 0.0173 0.0255
Schistosoma mansoni purine nucleoside phosphorylase 0.0123 0.1287 0.167
Giardia lamblia DINP protein human, muc B family 0.0021 0.0153 0.0333
Echinococcus multilocularis purine nucleoside phosphorylase 0.0123 0.1287 0.1281
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.002 0.0133 0.0164
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0133 0.0164
Loa Loa (eye worm) hypothetical protein 0.0014 0.0075 0.0108
Onchocerca volvulus 0.0144 0.1521 0.2806
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0266 0.0338
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0008 0.0007 0.0011
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0094 0.0485
Schistosoma mansoni potassium channel beta 0.0042 0.0379 0.0485
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0266 0.0383
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0046
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0811 0.1168
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0144 0.1521 0.1514
Loa Loa (eye worm) RecQ helicase 0.0012 0.0047 0.0067
Schistosoma mansoni pol-related 0.0144 0.1521 0.1975
Loa Loa (eye worm) hypothetical protein 0.0017 0.01 0.0144
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0266 0.0383
Echinococcus granulosus translational activator gcn1 0.0011 0.0038 0.0041
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0192
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0094 0.0087
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0266 0.048
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0266 0.0338
Brugia malayi NADH-dependent xylose reductase 0.0042 0.0379 0.0558
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0133 0.0196
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0376 0.0369
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.002 0.0133 0.0192
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0266 0.0259
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0079 0.0386
Echinococcus multilocularis lamin dm0 0.0014 0.0075 0.0068
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0133 0.0164
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0192
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0009 0.0015 0.0008
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0398 0.0586
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0153 0.0881
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0612 0.0789
Trichomonas vaginalis aldo-keto reductase, putative 0.0042 0.0379 0.069
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.001 0.0021 0.0018
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0078 0.0778 0.0771
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0266 0.0383
Onchocerca volvulus 0.0009 0.0015 0.0015
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0153 0.0411
Schistosoma mansoni smad1 5 8 and 0.0042 0.0383 0.049
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0153 0.0881
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0266 0.0338
Plasmodium vivax importin-beta 2, putative 0.0059 0.0572 0.9323
Onchocerca volvulus 0.0144 0.1521 0.2806
Mycobacterium tuberculosis Conserved protein 0.0042 0.0379 0.1975
Echinococcus multilocularis dna polymerase eta 0.0021 0.0153 0.0146
Echinococcus multilocularis aldehyde reductase 0.0102 0.1055 0.1049
Loa Loa (eye worm) hypothetical protein 0.0085 0.086 0.1239
Giardia lamblia UPL-1 0.0026 0.0198 0.0475
Schistosoma mansoni Smad4 0.0019 0.0123 0.0152
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.01 0.0093
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.1287 0.167
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0123 0.1287 0.8145
Brugia malayi nuclear receptor NHR-88 0.0015 0.008 0.0118
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0028 0.0027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3241 0.5996
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0266 0.0392
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0022
Echinococcus multilocularis uridine phosphorylase 1 0.0026 0.0198 0.0191
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0398 0.2516
Onchocerca volvulus 0.0144 0.1521 0.2806
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0008 0.0007 0.0011
Brugia malayi AF-10 protein 0.001 0.0022 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0266 0.0392
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.002 0.0133 0.0164
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0047 0.0171
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0572 0.3675
Schistosoma mansoni lamin 0.0014 0.0075 0.0088
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0255 0.2749 0.4046
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0094 0.0485
Trypanosoma brucei aldo/keto reductase, putative 0.0042 0.0379 0.2389
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0144 0.1521 0.1975
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0133 0.0196
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.018 0.0597
Loa Loa (eye worm) histone methyltransferase 0.0012 0.005 0.0072
Brugia malayi hypothetical protein 0.0015 0.008 0.0118
Onchocerca volvulus 0.0011 0.0032 0.0046
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0414 0.0407
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0144 0.1521 0.1514
Onchocerca volvulus 0.0011 0.0032 0.0046
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0133 0.0196
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0811 0.1049
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.002 0.0133 0.0196
Echinococcus multilocularis Smad4 0.0042 0.0383 0.0376
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0026 0.0198 0.0475
Entamoeba histolytica alcohol dehydrogenase, putative 0.0042 0.0379 0.115
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.002 0.0133 0.0196
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0026 0.0198 0.0723
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0133 0.0196
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0811 0.0804
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0627 0.062
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0198 0.0354
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.01 0.0121
Schistosoma mansoni aldo-keto reductase 0.0144 0.1521 0.1975
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0192
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0599 0.0863
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0144 0.1521 0.1975
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0026 0.0198 0.1182
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0579 0.0746
Trichomonas vaginalis aldo-keto reductase, putative 0.0144 0.1521 0.2806
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0115
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0078 0.0778 0.5048
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0153 0.0881
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0153 0.0881
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0094 0.132
Loa Loa (eye worm) ACC-1 protein 0.002 0.0133 0.0192
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0266 0.0338
Loa Loa (eye worm) GABA receptor subunit 0.0011 0.0032 0.0046
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0028 0.0021
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.086 0.1113
Echinococcus granulosus aldo keto reductase 0.0144 0.1521 0.1975
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0266 0.0259
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0011 0.0032 0.0047
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0144 0.1521 0.2238
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.018 0.1061
Brugia malayi jmjC domain containing protein 0.001 0.0021 0.0031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.2087 0.2714
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0078 0.0778 0.1121
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.1287 0.167
Echinococcus granulosus dna polymerase kappa 0.0021 0.0153 0.019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0266 0.0383
Trypanosoma brucei uridine phosphorylase 0.0026 0.0198 0.1182
Echinococcus granulosus neuropeptide receptor A26 0.0473 0.5178 0.6747
Brugia malayi PHD-finger family protein 0.003 0.0246 0.0362
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.005 0.0043
Brugia malayi Bromodomain containing protein 0.0034 0.0291 0.0428
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0266 0.0392
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0009 0.0015 0.0008
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0153 0.0451
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0022
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0133 0.0164
Echinococcus multilocularis nAChR subunit 0.0011 0.0032 0.0025
Plasmodium falciparum aldehyde reductase, putative 0.0042 0.0379 0.6501
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0098 0.1003 0.1299
Loa Loa (eye worm) hypothetical protein 0.0098 0.1003 0.1445
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0266 0.0338
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0133 0.0196
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0133 0.0164
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0266 0.048
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0009 0.0015 0.0022
Brugia malayi tailless protein 0.0015 0.008 0.0118
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0115
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0133 0.0126
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0811 0.1049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0266 0.0383
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0026 0.0198 0.0325
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0144 0.1521 0.1975
Schistosoma mansoni hypothetical protein 0.0105 0.108 0.14
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.018 0.2886
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0105 0.108 0.1589
Brugia malayi intermediate filament protein 0.0014 0.0075 0.011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0336 0.0429
Entamoeba histolytica hypothetical protein 0.0026 0.0198 0.0591
Echinococcus multilocularis neuropeptide s receptor 0.0473 0.5178 0.5175
Loa Loa (eye worm) hypothetical protein 0.0032 0.0266 0.0383
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.086 0.1266
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0784 0.0777
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0192
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0612 0.3942
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0627 0.4039
Mycobacterium leprae Possible oxidoreductase 0.0042 0.0379 0.1465
Onchocerca volvulus 0.002 0.0133 0.0234
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0144 0.1521 0.1514
Brugia malayi isocitrate dehydrogenase 0.0016 0.0094 0.0138
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0612 0.0789
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0144 0.1521 0.2238
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0144 0.1521 0.1514
Giardia lamblia PHD finger protein 15 0.003 0.0246 0.0623
Brugia malayi ecdysone receptor 0.0015 0.008 0.0118
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.008 0.0073
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0153 0.0411
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0266 0.0392
Mycobacterium tuberculosis Conserved hypothetical protein 0.0026 0.0198 0.0723
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0627 0.0808
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0026 0.0198 0.0591
Schistosoma mansoni hypothetical protein 0.0011 0.0039 0.0041
Plasmodium falciparum transportin 0.0011 0.0038 0.0315
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0022 0.0009
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0246 0.0239
Echinococcus granulosus jumonji domain containing 1A 0.001 0.0021 0.0018
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0094 0.0087
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.018 0.2691
Schistosoma mansoni intermediate filament proteins 0.0014 0.0075 0.0088
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.0038 0.0055
Onchocerca volvulus 0.0105 0.108 0.1989
Schistosoma mansoni uridine phosphorylase 0.0026 0.0198 0.0249
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0123 0.1287 0.3883
Schistosoma mansoni Smad4 0.0019 0.0123 0.0152
Echinococcus granulosus histone acetyltransferase KAT2B 0.0161 0.1703 0.2212
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0012 0.0047 0.0466
Echinococcus granulosus methylthioadenosine phosphorylase 0.0026 0.0198 0.0249
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0153 0.0881
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0133 0.0164
Onchocerca volvulus Putative nachr subunit 0.002 0.0133 0.0234
Loa Loa (eye worm) hypothetical protein 0.0008 0.0007 0.001
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0008 0.0007 0.001
Entamoeba histolytica aldose reductase, putative 0.0144 0.1521 0.468
Brugia malayi mothers against decapentaplegic homolog 3 0.0019 0.0123 0.0182
Loa Loa (eye worm) hypothetical protein 0.0032 0.0266 0.0383
Schistosoma mansoni uridine phosphorylase 0.0026 0.0198 0.0249
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0011 0.0032 0.0032
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0026 0.0198 0.0059
Schistosoma mansoni nuclear hormone receptor 0.0015 0.008 0.0095
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0042 0.0379 0.2389
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.002 0.0133 0.0196
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0144 0.1521 0.1975
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0144 0.1521 0.1514
Loa Loa (eye worm) hypothetical protein 0.0017 0.01 0.0144
Mycobacterium tuberculosis Probable oxidoreductase 0.0144 0.1521 0.9871
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0021 0.003
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0123 0.0178
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.002 0.0133 0.0126
Onchocerca volvulus 0.0015 0.008 0.0135
Echinococcus multilocularis peregrin 0.0034 0.0291 0.0284
Onchocerca volvulus 0.0085 0.086 0.1582
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0133 0.0126
Brugia malayi latrophilin 2 splice variant baaae 0.0174 0.1852 0.2725
Brugia malayi acetyltransferase, GNAT family protein 0.0165 0.1755 0.2582
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0192 0.311
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.041 0.7059
Loa Loa (eye worm) hypothetical protein 0.0105 0.1079 0.1555
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0.0123 0.0152
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0133 0.0196
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0133 0.0164
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0009 0.0015 0.0008
Schistosoma mansoni nAChR subunit 0.002 0.0133 0.0164
Echinococcus multilocularis snurportin 1 0.0631 0.6941 0.6939
Brugia malayi MH1 domain containing protein 0.0042 0.0383 0.0563
Loa Loa (eye worm) acetylcholine receptor protein 0.0009 0.0015 0.0022
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.018 0.1061
Trichomonas vaginalis aldo-keto reductase, putative 0.0042 0.0379 0.069
Schistosoma mansoni neurotransmitter gated ion channel 0.0011 0.0032 0.0032
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.018 0.0194
Brugia malayi MH1 domain containing protein 0.0023 0.0173 0.0255
Trichomonas vaginalis aldo-keto reductase, putative 0.0144 0.1521 0.2806
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0661 0.4269
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.008 0.0118
Loa Loa (eye worm) hypothetical protein 0.0032 0.0266 0.0383
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0015 0.0022
Echinococcus granulosus GPCR family 2 0.0081 0.0811 0.1049
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.086 0.0854
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0133 0.0196
Brugia malayi excitatory GABA receptor EXP-1A 0.002 0.0133 0.0196
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0009 0.0015 0.0022
Leishmania major hypothetical protein, conserved 0.0011 0.0038 0.0116
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0133 0.0126
Brugia malayi Intermediate filament tail domain containing protein 0.0014 0.0075 0.011
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0398 0.2516
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0198 0.0354
Loa Loa (eye worm) oxidoreductase 0.0144 0.1521 0.2191
Schistosoma mansoni nuclear receptor 0.0015 0.008 0.0095
Schistosoma mansoni hypothetical protein 0.003 0.0246 0.0311
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0383 0.049
Brugia malayi steroid hormone receptor 0.0032 0.0266 0.0392
Echinococcus granulosus integrin alpha ps 0.003 0.0245 0.031
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0246 0.0311
Schistosoma mansoni hypothetical protein 0.003 0.0245 0.031
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0039 0.0041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0266 0.0338
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0811 0.1193
Loa Loa (eye worm) oxidoreductase 0.0144 0.1521 0.2191
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0.0123 0.0152
Loa Loa (eye worm) oxidoreductase 0.0144 0.1521 0.2191
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.008 0.0095
Loa Loa (eye worm) transcription factor SMAD2 0.0618 0.6796 0.979
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0383 0.0551
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0266 0.0392
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0198 0.0354
Echinococcus multilocularis purine nucleoside phosphorylase 0.0123 0.1287 0.1281
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0094 0.0485
Loa Loa (eye worm) ACC-1 protein 0.002 0.0133 0.0192
Toxoplasma gondii Purine nucleoside phosphorylase 0.0026 0.0198 0.1182
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.008 0.0073
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.008 0.0073
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0455 0.0584
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0133 0.0196
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.3241 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0811 0.1168
Echinococcus multilocularis geminin 0.0697 0.7672 0.767
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0008 0.0007 0.0011
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0165 0.1755 0.1749
Schistosoma mansoni DNA helicase recq1 0.0012 0.0047 0.0051
Echinococcus granulosus importin subunit beta 1 0.0059 0.0572 0.0737
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0195 0.2087 0.2082
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3241 0.5996
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0448 0.0817
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0078 0.0778 0.1006
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0398 0.6383
Plasmodium vivax aldehyde reductase, putative 0.0042 0.0379 0.6061
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0777 0.1005
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.008 0.0095
Schistosoma mansoni smad1 5 8 and 0.0042 0.0383 0.049
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0266 0.0338
Loa Loa (eye worm) LGC-31 protein 0.002 0.0133 0.0192
Toxoplasma gondii HEAT repeat-containing protein 0.0011 0.0038 0.0116
Entamoeba histolytica aldose reductase, putative 0.0144 0.1521 0.468
Loa Loa (eye worm) hypothetical protein 0.0144 0.1521 0.2191
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0266 0.0392
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0022
Brugia malayi hypothetical protein 0.0025 0.0192 0.0283
Loa Loa (eye worm) hypothetical protein 0.0023 0.0173 0.0249
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0014 0.0075 0.0108
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0026 0.0198 0.0591
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0246 0.0311
Loa Loa (eye worm) uridine phosphorylase 0.0026 0.0198 0.0286
Loa Loa (eye worm) hypothetical protein 0.0008 0.0007 0.001
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0153 0.0881
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0011 0.0038 0.0116
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0153 0.019
Brugia malayi hypothetical protein 0.0015 0.008 0.0118
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0022 0.0009
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0026 0.0198 0.1182
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0266 0.0259
Trichomonas vaginalis aldo-keto reductase, putative 0.0042 0.0379 0.069
Echinococcus granulosus smad 0.0042 0.0383 0.049
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0021 0.003
Toxoplasma gondii aldo-keto reductase 0.0042 0.0379 0.2389
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0133 0.0126
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0192
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0153 0.0881
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0105 0.1079 0.1588
Echinococcus granulosus dnaJ subfamily B 0.0457 0.5001 0.6516
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0266 0.0392
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0144 0.1521 0.1514
Leishmania major importin beta-1 subunit, putative 0.0048 0.0448 0.2845
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0144 0.1521 0.1514
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0022
Echinococcus granulosus neuropeptide s receptor 0.0473 0.5178 0.6747
Echinococcus multilocularis aldo keto reductase 0.0144 0.1521 0.1514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0398 0.2516
Schistosoma mansoni coup transcription factor 0.0032 0.0266 0.0338
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0165 0.1755 0.228
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0198 0.0354
Onchocerca volvulus 0.0042 0.0379 0.069
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0266 0.0383
Onchocerca volvulus 0.002 0.0133 0.0234
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.008 0.0073
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0192
Loa Loa (eye worm) acetyltransferase 0.0165 0.1755 0.2528
Schistosoma mansoni smad1 5 8 and 0.0042 0.0383 0.049
Trichomonas vaginalis aldo/keto reductase, putative 0.0144 0.1521 0.2806
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0376 0.0481
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0047 0.0171
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0046
Schistosoma mansoni nAChR subunit 0.002 0.0133 0.0164
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0266 0.0338
Schistosoma mansoni nAChR subunit 0.002 0.0133 0.0164
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.3241 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0266 0.0392
Loa Loa (eye worm) hypothetical protein 0.0017 0.01 0.0144
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0198 0.0354
Schistosoma mansoni hypothetical protein 0.0697 0.7672 1
Echinococcus granulosus bloom syndrome protein 0.0012 0.0047 0.0051
Schistosoma mansoni hypothetical protein 0.0078 0.0784 0.1013
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0266 0.0338
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0008 0.0007 0.001
Chlamydia trachomatis AMP nucleosidase 0.0026 0.0198 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0153 0.0271
Schistosoma mansoni hypothetical protein 0.0631 0.6941 0.9047
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0047 0.0067
Leishmania major aldo-keto reductase-like protein 0.0144 0.1521 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0007 0.001
Brugia malayi nuclear receptor RXR 0.0017 0.01 0.0147
Entamoeba histolytica hypothetical protein 0.0078 0.0784 0.2401
Schistosoma mansoni purine nucleoside phosphorylase 0.0123 0.1287 0.167
Brugia malayi CXXC zinc finger family protein 0.0032 0.0271 0.0399
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0032 0.0273 0.0394
Echinococcus multilocularis integrin alpha ps 0.003 0.0245 0.0238
Echinococcus granulosus hypothetical protein 0.0144 0.1521 0.1975
Trichomonas vaginalis aldo-keto reductase, putative 0.0144 0.1521 0.2806
Entamoeba histolytica hypothetical protein 0.0078 0.0784 0.2401
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.002 0.0133 0.0164
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.01 0.0121
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0047 0.0039
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0115
Treponema pallidum pfs protein (pfs) 0.0026 0.0198 0.0059
Schistosoma mansoni hypothetical protein 0.0081 0.0811 0.1049
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0042 0.0379 0.2389
Mycobacterium tuberculosis Hypothetical protein 0.0026 0.0198 0.0723
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0.0123 0.0116
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0153 0.0146
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0266 0.0338
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.002 0.0133 0.0192
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0115
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0094 0.0485
Brugia malayi nuclear receptor RXR 0.0015 0.008 0.0118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.2087 0.2714
Brugia malayi nuclear hormone receptor 0.0015 0.008 0.0118
Echinococcus granulosus peregrin 0.0034 0.0291 0.037
Echinococcus multilocularis integrin alpha ps 0.0062 0.0605 0.0598
Schistosoma mansoni neurotransmitter gated ion channel 0.0009 0.0015 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0153 0.0881
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.3241 1
Onchocerca volvulus 0.002 0.0133 0.0234
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.002 0.0133 0.0192
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0123 0.1287 0.1894
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0192 0.1143
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0047 0.0171
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0266 0.0338
Schistosoma mansoni methylthioadenosine phosphorylase 0.0026 0.0198 0.0249
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.005 0.0056
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0133 0.0196
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0414 0.0531
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0448 0.2845
Loa Loa (eye worm) oxidoreductase 0.0144 0.1521 0.2191
Schistosoma mansoni DNA helicase recq5 0.0012 0.0047 0.0051
Loa Loa (eye worm) hypothetical protein 0.0017 0.01 0.0144
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0021 0.003
Brugia malayi Pre-SET motif family protein 0.0433 0.4735 0.6968
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.002 0.0133 0.0196
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.0508 0.5567 1
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0026 0.0198 0.0591
Loa Loa (eye worm) DR-78 0.0015 0.008 0.0115
Mycobacterium leprae probable uridine phosphorylase 0.0026 0.0198 0.0134
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0078 0.0778 0.1006
Echinococcus granulosus importin 5 0.0011 0.0038 0.0041
Loa Loa (eye worm) hypothetical protein 0.0025 0.0192 0.0277
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0094 0.123
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0115
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.002 0.0133 0.0126
Brugia malayi Nuclear hormone receptor E75 0.0015 0.008 0.0118
Echinococcus multilocularis purine nucleoside phosphorylase 0.0123 0.1287 0.1281
Mycobacterium ulcerans oxidoreductase 0.0144 0.1521 0.9865
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.01 0.0144
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0153 0.0881
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0144 0.1521 0.1514
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0192
Schistosoma mansoni importin beta-1 0.0059 0.0572 0.0737
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0192 0.29
Trypanosoma brucei prostaglandin f synthase 0.0144 0.1521 1
Echinococcus multilocularis smad 0.0042 0.0383 0.0376
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0008 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0192
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0009 0.0015 0.0022
Onchocerca volvulus 0.0144 0.1521 0.2806
Trypanosoma brucei unspecified product 0.0015 0.0079 0.0386
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0.0123 0.0116
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0133 0.0126
Brugia malayi MH2 domain containing protein 0.0042 0.0383 0.0563
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.008 0.0118
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.0007 0.0011
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0627 0.0808
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0192
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0627 0.4039
Brugia malayi jmjC domain containing protein 0.001 0.0021 0.0031
Echinococcus multilocularis purine nucleoside phosphorylase 0.0098 0.1003 0.0996
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0153 0.019
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0094 0.0485
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.1287 0.167
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0398 0.6847
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0008 0.0007 0.0011
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.1001 0.0994
Schistosoma mansoni hypothetical protein 0.001 0.0022 0.002
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0144 0.1521 0.2806
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0028 0.0027
Schistosoma mansoni integrin alpha-ps 0.0062 0.0605 0.0779
Schistosoma mansoni nuclear hormone receptor 0.0015 0.008 0.0095
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0398 0.1101
Echinococcus multilocularis nAChR subunit 0.002 0.0133 0.0126
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.1287 0.167
Trichomonas vaginalis aldo-keto reductase, putative 0.0144 0.1521 0.2806
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0266 0.0338
Schistosoma mansoni survival motor neuron protein 0.0105 0.108 0.14
Brugia malayi hypothetical protein 0.0016 0.0094 0.0138
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0144 0.1521 0.2238
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0255 0.2749 0.3961
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0094 0.0113
Onchocerca volvulus 0.0144 0.1521 0.2806
Schistosoma mansoni hypothetical protein 0.0081 0.0811 0.1049
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0316 0.0309
Brugia malayi MH1 domain containing protein 0.0042 0.0383 0.0563
Brugia malayi kap beta 3 protein 0.0011 0.0038 0.0056
Giardia lamblia Aldose reductase 0.0144 0.1521 0.4614
Schistosoma mansoni ran 0.0044 0.0398 0.051
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0047 0.0171
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0144 0.1521 0.2806
Schistosoma mansoni hypothetical protein 0.0457 0.5001 0.6516
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0383 0.049
Echinococcus multilocularis survival motor neuron protein 1 0.0513 0.5631 0.5628
Loa Loa (eye worm) hypothetical protein 0.0051 0.0483 0.0696
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0383 0.0376
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0047 0.0039
Echinococcus multilocularis aldo keto reductase 0.0144 0.1521 0.1514
Brugia malayi conserved hypotetical protein 0.0015 0.008 0.0118
Loa Loa (eye worm) intermediate filament protein 0.0014 0.0075 0.0108
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0336 0.0429
Loa Loa (eye worm) hypothetical protein 0.0032 0.0266 0.0383
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0192
Brugia malayi jmjC domain containing protein 0.001 0.0021 0.0031
Leishmania major methylthioadenosine phosphorylase, putative 0.0026 0.0198 0.1182
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0266 0.0259
Toxoplasma gondii phosphorylase family protein 0.0026 0.0198 0.1182
Echinococcus multilocularis purine nucleoside phosphorylase 0.0123 0.1287 0.1281
Brugia malayi Bloom's syndrome protein homolog 0.0012 0.0047 0.0069
Brugia malayi G-protein alpha subunit 0.0008 0.0007 0.0011
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0123 0.1287 0.2373
Schistosoma mansoni smad 0.0042 0.0383 0.049
Brugia malayi uridine phosphorylase family protein 0.0026 0.0198 0.0292
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.1539 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.0047 0.0466
Leishmania major prostaglandin f synthase, putative 0.0144 0.1521 1
Brugia malayi RNA, U transporter 1 0.0168 0.1786 0.2628
Entamoeba histolytica HEAT repeat domain containing protein 0.0011 0.0038 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0266 0.0392
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0192 0.1143
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.1287 0.167
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0153 0.0881
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0026 0.0198 0.2998
Schistosoma mansoni nuclear receptor 0.0015 0.008 0.0095
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0011 0.0032 0.0047
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.002 0.0133 0.0196
Echinococcus multilocularis aldo keto reductase 0.0144 0.1521 0.1514
Brugia malayi hypothetical protein 0.0513 0.5631 0.8286
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.008 0.0073
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0133 0.0126
Brugia malayi hypothetical protein 0.0008 0.0007 0.0011
Schistosoma mansoni importin-beta 2 0.0011 0.0038 0.0041
Echinococcus multilocularis musashi 0.0014 0.0075 0.0068
Schistosoma mansoni methylthioadenosine phosphorylase 0.0026 0.0198 0.0249
Entamoeba histolytica hypothetical protein 0.0024 0.018 0.0534
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0094 0.0485
Echinococcus multilocularis transportin 1 0.0011 0.0038 0.0031
Brugia malayi nuclear receptor NHR-88 0.0032 0.0266 0.0392
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0144 0.1521 0.9863
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0631 0.6941 1
Echinococcus granulosus integrin alpha ps 0.0062 0.0605 0.0779
Entamoeba histolytica hypothetical protein 0.0011 0.0032 0.0077
Echinococcus multilocularis integrin alpha 3 0.003 0.0245 0.0238
Leishmania major nucleoside phosphorylase-like protein 0.0026 0.0198 0.1182
Brugia malayi hypothetical protein 0.0009 0.0015 0.0022
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.002 0.0133 0.0192
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0094 0.0138
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0627 0.3416
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0266 0.0338
Schistosoma mansoni nAChR subunit 0.002 0.0133 0.0164
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0044 0.0391
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0266 0.0392
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0153 0.0881
Brugia malayi nuclear hormone receptor 0.0032 0.0266 0.0392
Echinococcus granulosus uridine phosphorylase 1 0.0026 0.0198 0.0249
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0192
Onchocerca volvulus 0.002 0.0133 0.0234
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.3241 1
Mycobacterium ulcerans hypothetical protein 0.0042 0.0379 0.1631
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.008 0.0095
Plasmodium falciparum importin beta, putative 0.0059 0.0572 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.018 0.1061
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.01 0.0147
Echinococcus granulosus snurportin 1 0.0631 0.6941 0.9047
Entamoeba histolytica hypothetical protein 0.0078 0.0784 0.2401
Schistosoma mansoni zinc finger protein 0.0015 0.008 0.0095
Onchocerca volvulus 0.0015 0.008 0.0135
Loa Loa (eye worm) G protein alpha subunit 3 0.0008 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.003
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0198 0.0354
Echinococcus multilocularis GPCR, family 2 0.0081 0.0811 0.0804
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0455 0.7345
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0094 0.0113
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0627 0.3687
Onchocerca volvulus 0.0009 0.0015 0.0015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0153 0.0881
Brugia malayi hypothetical protein 0.0078 0.0784 0.1153
Loa Loa (eye worm) hypothetical protein 0.003 0.0245 0.0353
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.0041 0.0034
Echinococcus granulosus lamin 0.0014 0.0075 0.0088
Trichomonas vaginalis aldo/keto reductase, putative 0.0144 0.1521 0.2806
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0192
Echinococcus multilocularis JmjC domain containing protein 4 0.001 0.0021 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0079 0.0386
Brugia malayi MH2 domain containing protein 0.0042 0.0383 0.0563
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0266 0.0338
Trichomonas vaginalis aldo-keto reductase, putative 0.0144 0.1521 0.2806
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0008 0.0007 0.001
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0008 0.0007 0.001
Schistosoma mansoni integrin alpha-ps 0.0032 0.0273 0.0347
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0697 0.09
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0094 0.0135
Echinococcus granulosus dna polymerase eta 0.0021 0.0153 0.019
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0026 0.0198 0.0325
Echinococcus multilocularis dnaJ subfamily B 0.0457 0.5001 0.4998
Entamoeba histolytica hypothetical protein 0.0048 0.0448 0.1362
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0144 0.1521 0.1975
Schistosoma mansoni neurotransmitter gated ion channel 0.0009 0.0015 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0046
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0115
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0612 0.0605
Leishmania major DNA polymerase eta, putative 0.0021 0.0153 0.0881
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.002 0.0133 0.0192
Brugia malayi jmjC domain containing protein 0.0038 0.0336 0.0494
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.2087 0.2714
Schistosoma mansoni phosphatidylserine receptor 0.001 0.0021 0.0018
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0047 0.0051
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0115
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0144 0.1521 0.2238
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0198 0.0354
Echinococcus multilocularis purine nucleoside phosphorylase 0.0098 0.1003 0.0996
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0266 0.0392
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.002 0.0133 0.0164
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0115
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.0007 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0266 0.0392
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0153 0.0225
Schistosoma mansoni hypothetical protein 0.0697 0.7672 1
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0042 0.0379 0.069
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0144 0.1521 0.1975
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3241 0.5996
Trypanosoma cruzi aldo-keto reductase 0.0144 0.1521 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0266 0.0338
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0778 0.5048
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0627 0.3416
Loa Loa (eye worm) hypothetical protein 0.0255 0.2749 0.3961
Leishmania major GTP-binding protein, putative 0.0044 0.0398 0.2516
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.041 0.1246
Brugia malayi jmjC domain containing protein 0.0098 0.1001 0.1473
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0026 0.0198 0.0591
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0115
Onchocerca volvulus 0.0144 0.1521 0.2806
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0153 0.0881
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.002 0.0133 0.0126
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0123 0.1287 0.2373
Loa Loa (eye worm) oxidoreductase 0.0144 0.1521 0.2191
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0153 0.0881
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0011 0.0038 0.0116
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.002 0.0133 0.0192
Schistosoma mansoni nAChR subunit 0.0009 0.0015 0.001
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0144 0.1521 0.1514
Onchocerca volvulus 0.0493 0.5401 1
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0047 0.0073
Brugia malayi MH2 domain containing protein 0.0618 0.6796 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0144 0.1521 0.2806
Plasmodium vivax hypothetical protein, conserved 0.003 0.0246 0.3802
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0046
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.1539 1
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0008 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0115
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.008 0.0118
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0612 0.0605
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0078 0.0778 0.1145
Onchocerca volvulus 0.002 0.0133 0.0234
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0042 0.0379 0.0485
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.1287 0.167
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.008 0.0095
Giardia lamblia Aldose reductase 0.0144 0.1521 0.4614
Brugia malayi Calcitonin receptor-like protein seb-1 0.0255 0.2749 0.4046
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0144 0.1521 1
Mycobacterium leprae Conserved hypothetical protein 0.0102 0.1055 0.6439
Plasmodium falciparum purine nucleoside phosphorylase 0.0026 0.0198 0.3216
Schistosoma mansoni protein phosphatase 2C 0.001 0.0021 0.0018
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0039 0.0032
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0336 0.0429
Loa Loa (eye worm) hypothetical protein 0.003 0.0246 0.0354
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0123 0.1287 0.8256
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.0038 0.0055
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0612 0.0789
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0383 0.0376
Brugia malayi Cation transporter family protein 0.002 0.0133 0.0196
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0398 0.2516
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.01 0.0121
Echinococcus multilocularis voltage gated potassium channel subunit 0.0042 0.0379 0.0372
Echinococcus granulosus cpg binding protein 0.0034 0.0291 0.0371
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0022
Trichomonas vaginalis aldo-keto reductase, putative 0.0144 0.1521 0.2806
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0046
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0153 0.0271
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0047 0.0122
Brugia malayi hypothetical protein 0.0009 0.0015 0.0022
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0144 0.1521 0.1514
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0246 0.1499
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0026 0.0198 0.1182
Echinococcus granulosus survival motor neuron protein 1 0.0513 0.5631 0.7338
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0115
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.01 0.0147
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0195 0.2087 0.3072
Schistosoma mansoni integrin alpha 0.0062 0.0605 0.0779
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.008 0.0095
Echinococcus granulosus aldo keto reductase 0.0144 0.1521 0.1975
Schistosoma mansoni jumonji domain containing protein 0.001 0.0021 0.0018
Trichomonas vaginalis set domain proteins, putative 0.0493 0.5401 1
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0572 0.0565
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0026 0.0198 0.0286
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0266 0.0338
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0192 0.1143
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0398 0.0391
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0192
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0784 0.1013
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0042 0.0379 0.0558
Echinococcus granulosus aldehyde reductase 0.0102 0.1055 0.1367
Loa Loa (eye worm) hypothetical protein 0.0513 0.5631 0.8113
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0627 0.3416
Schistosoma mansoni lamin 0.0014 0.0075 0.0088
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.008 0.0115
Loa Loa (eye worm) hypothetical protein 0.0032 0.0266 0.0383
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0022
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0133 0.0164
Schistosoma mansoni nAChR subunit 0.002 0.0133 0.0164
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0022
Schistosoma mansoni aldo-keto reductase 0.0144 0.1521 0.1975
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0133 0.0196
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0026 0.0198 0.0191
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0266 0.0383
Schistosoma mansoni cpg binding protein 0.0034 0.0291 0.0371
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0192
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0195 0.2087 0.2082
Echinococcus granulosus geminin 0.0697 0.7672 1
Echinococcus multilocularis integrin alpha ps 0.0062 0.0605 0.0598
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0455 0.0831
Schistosoma mansoni phd/f-box containing protein 0.001 0.0021 0.0018
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.002 0.0133 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0079 0.0386
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.002 0.0133 0.0164
Echinococcus multilocularis lamin 0.0014 0.0075 0.0068
Toxoplasma gondii phosphorylase family protein 0.0026 0.0198 0.1182
Echinococcus multilocularis jumonji domain containing 1A 0.001 0.0021 0.0014
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0028 0.0021
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.1539 1
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0266 0.0338
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0266 0.0259
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0022
Echinococcus granulosus nAChR subunit 0.0011 0.0032 0.0032
Brugia malayi Cation transporter family protein 0.002 0.0133 0.0196
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0133 0.0164
Schistosoma mansoni cpg binding protein 0.0034 0.0291 0.0371
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0778 0.5048
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0192
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0198 0.0354
Treponema pallidum uridine phosphorylase (udp) 0.0026 0.0198 0.0059
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3241 0.5996
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0266 0.0338
Entamoeba histolytica alcohol dehydrogenase, putative 0.0042 0.0379 0.115
Echinococcus multilocularis importin 5 0.0011 0.0038 0.0031
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0153 0.0225
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0195 0.2087 0.3007
Entamoeba histolytica aldose reductase, putative 0.0144 0.1521 0.468
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0115
Echinococcus granulosus aldo keto reductase 0.0144 0.1521 0.1975
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0144 0.1521 0.1514
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0144 0.1521 0.1975
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0046
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.008 0.0135
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0042 0.0379 0.2389
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0133 0.0164
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0042 0.0379 0.0546
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0448 0.0817
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0455 0.0831
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0266 0.0259
Loa Loa (eye worm) hypothetical protein 0.0017 0.01 0.0144
Toxoplasma gondii HEAT repeat-containing protein 0.0011 0.0038 0.0116
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0266 0.0338
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.0041 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0153 0.0881
Onchocerca volvulus 0.0032 0.0266 0.048
Onchocerca volvulus 0.0014 0.0075 0.0125
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0011 0.0032 0.0032
Schistosoma mansoni nAChR subunit 0.0009 0.0015 0.001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0811 0.0804
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0153 0.0881
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0026 0.0198 0.1182
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0192 0.311
Entamoeba histolytica hypothetical protein 0.0078 0.0784 0.2401
Echinococcus granulosus intermediate filament protein 0.0014 0.0075 0.0088
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.0007 0.0011
Schistosoma mansoni polycystin 1-related 0.0045 0.0411 0.0526
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0047 0.0051
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0094 0.0087
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0094 0.0087
Brugia malayi MTAP 0.0026 0.0198 0.0292
Leishmania major DNA polymerase kappa, putative 0.0021 0.0153 0.0881
Leishmania major hypothetical protein, conserved 0.0025 0.0192 0.1143
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.003
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.002 0.0133 0.0164
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.018 0.1061
Echinococcus granulosus transportin 1 0.0011 0.0038 0.0041
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0157 0.0231

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) <= 0.049 ug ml-1 In vitro antibacterial activity against gram-positive S. pneumoniae ChEMBL. 14698166
MIC (functional) = 0.195 ug ml-1 In vitro antibacterial activity against gram-positive S. aureus ChEMBL. 14698166
MIC (functional) = 0.78 ug ml-1 In vitro antibacterial activity against gram-negative S. boydii ChEMBL. 14698166
MIC (functional) = 1.56 ug ml-1 In vitro antibacterial activity against gram-positive S. epidermidis ChEMBL. 14698166
MIC (functional) = 1.56 ug ml-1 In vitro antibacterial activity against gram-negative K. pneumoniae ChEMBL. 14698166
MIC (functional) = 1.56 ug ml-1 In vitro antibacterial activity against gram-negative Citrobacter freundii ChEMBL. 14698166

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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