Detailed information for compound 277367

Basic information

Technical information
  • TDR Targets ID: 277367
  • Name: 1-[2-(4-benzyl-2-methylphenoxy)ethyl]pyrrolid ine
  • MW: 295.419 | Formula: C20H25NO
  • H donors: 0 H acceptors: 0 LogP: 4.7 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(ccc1OCCN1CCCC1)Cc1ccccc1
  • InChi: 1S/C20H25NO/c1-17-15-19(16-18-7-3-2-4-8-18)9-10-20(17)22-14-13-21-11-5-6-12-21/h2-4,7-10,15H,5-6,11-14,16H2,1H3
  • InChiKey: ADTSNUGPRRSFRY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-(4-benzyl-2-methyl-phenoxy)ethyl]pyrrolidine
  • 1-[2-[2-methyl-4-(phenylmethyl)phenoxy]ethyl]pyrrolidine
  • 1-[2-[4-(benzyl)-2-methyl-phenoxy]ethyl]pyrrolidine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens leukotriene A4 hydrolase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) leukotriene A4 hydrolase Get druggable targets OG5_129538 All targets in OG5_129538
Echinococcus granulosus leukotriene A 4 hydrolase Get druggable targets OG5_129538 All targets in OG5_129538
Schistosoma japonicum ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative Get druggable targets OG5_129538 All targets in OG5_129538
Candida albicans leukotriene A4 hydrolase/leucyl aminopeptidase Get druggable targets OG5_129538 All targets in OG5_129538
Echinococcus multilocularis leukotriene A 4 hydrolase Get druggable targets OG5_129538 All targets in OG5_129538
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) Get druggable targets OG5_129538 All targets in OG5_129538
Candida albicans leukotriene A4 hydrolase/leucyl aminopeptidase Get druggable targets OG5_129538 All targets in OG5_129538
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 leukotriene A4 hydrolase 611 aa 508 aa 22.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis tubulin beta chain, putative 0.0205 0.1679 0.1643
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0007 0.0001 0.0002
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.023 0.1888 0.2294
Schistosoma mansoni hypothetical protein 0.0035 0.0235 0.0572
Schistosoma mansoni alpha tubulin 0.0205 0.1679 0.4085
Echinococcus multilocularis Polycystic kidney disease protein 0.0059 0.0443 0.079
Echinococcus granulosus Tubulin alpha 1 chain 0.0205 0.1679 0.2972
Leishmania major alpha tubulin 0.0205 0.1679 0.4023
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0067 0.0119
Plasmodium falciparum alpha tubulin 2 0.0205 0.1679 0.751
Trichomonas vaginalis tubulin beta chain, putative 0.0205 0.1679 0.1643
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0015 0.0067 0.012
Loa Loa (eye worm) hypothetical protein 0.0059 0.0443 0.1923
Echinococcus multilocularis 0.0017 0.0084 0.015
Brugia malayi MH1 domain containing protein 0.0008 0.0012 0.0049
Trypanosoma cruzi epsilon tubulin, putative 0.0147 0.1182 0.523
Trichomonas vaginalis tubulin, putative 0.0064 0.048 0.0439
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0829 0.079
Echinococcus multilocularis tubulin alpha chain 0.0205 0.1679 0.2994
Echinococcus granulosus CalModulin family member cmd 1 0.0012 0.0046 0.0082
Echinococcus multilocularis aminopeptidase N 0.0015 0.0067 0.012
Echinococcus granulosus CTD small phosphatase protein like 0.0012 0.0043 0.0076
Loa Loa (eye worm) tubulin gamma chain 0.0147 0.1182 0.5138
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0067 0.0163
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0386 0.1575
Leishmania major zeta tubulin, putative 0.0064 0.048 0.1075
Schistosoma mansoni tyrosine kinase 0.0058 0.043 0.1045
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0015 0.0067 0.012
Loa Loa (eye worm) animal heme peroxidase 0.0083 0.0647 0.2808
Trypanosoma brucei tubulin delta chain 0.0064 0.048 0.2007
Schistosoma mansoni smad 0.0008 0.0012 0.0029
Echinococcus granulosus tubulin alpha 1C chain 0.0205 0.1679 0.2972
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0067 0.0298
Giardia lamblia Fructose-bisphosphate aldolase 0.0282 0.2328 1
Onchocerca volvulus Peroxidase homolog 0.0083 0.0647 0.3972
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0015 0.0067 0.0119
Giardia lamblia Gamma tubulin 0.0147 0.1182 0.4985
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0078 0.0159
Echinococcus multilocularis Tubulin beta 2C chain 0.027 0.2221 0.3961
Loa Loa (eye worm) doublecortin family protein 0.0059 0.0443 0.1923
Loa Loa (eye worm) hypothetical protein 0.0059 0.0443 0.1923
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0007 0.0001 0.0002
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.0829 0.1934
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.0829 0.0962
Schistosoma mansoni smad1 5 8 and 0.0008 0.0012 0.0029
Echinococcus granulosus Ankyrin 0.0015 0.0071 0.0125
Mycobacterium leprae Probable transmembrane transport protein 0.023 0.1888 0.3878
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0015 0.0067 0.011
Leishmania major beta tubulin 0.027 0.2221 0.5357
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0015 0.0067 0.012
Trypanosoma brucei alpha tubulin 0.0205 0.1679 0.751
Echinococcus multilocularis tubulin alpha chain 0.0205 0.1679 0.2994
Trypanosoma brucei alpha tubulin 0.0205 0.1679 0.751
Loa Loa (eye worm) peptidase family M1 containing protein 0.0015 0.0067 0.0288
Plasmodium falciparum tubulin epsilon chain, putative 0.0147 0.1182 0.523
Trypanosoma cruzi alpha tubulin, putative 0.0205 0.1679 0.751
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0077 0.0596 0.1062
Trichomonas vaginalis tubulin epsilon chain, putative 0.027 0.2221 0.2188
Brugia malayi Tubulin gamma chain 0.0147 0.1182 0.532
Loa Loa (eye worm) hypothetical protein 0.007 0.0537 0.2331
Toxoplasma gondii calmodulin, putative 0.0012 0.0046 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2328 0.2295
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0078 0.0137
Schistosoma mansoni steroid hormone receptor ad4bp 0.0015 0.0067 0.0163
Brugia malayi Protein kinase domain containing protein 0.0071 0.0546 0.2454
Echinococcus multilocularis calmodulin 0.0012 0.0046 0.0083
Echinococcus multilocularis lipoxygenase domain containing protein 0.0059 0.0443 0.079
Brugia malayi hypothetical protein 0.0083 0.0647 0.2908
Leishmania major gamma-tubulin 0.0147 0.1182 0.2801
Loa Loa (eye worm) animal heme peroxidase 0.0083 0.0647 0.2808
Schistosoma mansoni smad1 5 8 and 0.0008 0.0012 0.0029
Entamoeba histolytica tubulin alpha-1 chain 0.0205 0.1679 0.4023
Schistosoma mansoni rab6-interacting 0.0059 0.0443 0.1078
Loa Loa (eye worm) tubulin alpha-2 chain 0.0205 0.1679 0.7298
Loa Loa (eye worm) hypothetical protein 0.0144 0.1162 0.5048
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0015 0.0067 0.011
Echinococcus granulosus peroxisome assembly protein 26 0.0205 0.1679 0.2972
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.0829 0.1468
Leishmania major beta tubulin 0.027 0.2221 0.5357
Brugia malayi Uncoordinated protein 44 0.0015 0.0069 0.0309
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0078 0.0159
Echinococcus multilocularis carbonic anhydrase 0.0027 0.0171 0.0305
Echinococcus granulosus dnaJ subfamily B 0.0395 0.3282 0.5808
Schistosoma mansoni carbonic anhydrase 0.0027 0.0171 0.0416
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0829 0.361
Plasmodium vivax delta tubulin, putative 0.0064 0.048 0.2007
Trypanosoma brucei tubulin gamma chain 0.0147 0.1182 0.523
Schistosoma mansoni carbonic anhydrase 0.0493 0.411 1
Schistosoma mansoni tubulin subunit beta 0.027 0.2221 0.5405
Schistosoma mansoni hypothetical protein 0.0016 0.0078 0.0189
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0288
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0288
Leishmania major alpha tubulin 0.0205 0.1679 0.4023
Trypanosoma brucei epsilon tubulin 0.0147 0.1182 0.523
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0829 0.361
Brugia malayi Furin-like cysteine rich region family protein 0.0059 0.0438 0.1971
Loa Loa (eye worm) hypothetical protein 0.0016 0.0078 0.0334
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0015 0.0067 0.011
Brugia malayi photoreceptor-specific nuclear receptor 0.0015 0.0067 0.0298
Brugia malayi hypothetical protein 0.0154 0.1243 0.5594
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0315 0.0558
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0031
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0043 0.0105
Loa Loa (eye worm) Smad1 0.0008 0.0012 0.0047
Brugia malayi Peptidase family M1 containing protein 0.0015 0.0067 0.0298
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0279 0.23 0.5597
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.021 0.0767
Leishmania major epsilon tubulin, putative 0.0147 0.1182 0.2801
Onchocerca volvulus 0.0083 0.0647 0.3972
Echinococcus granulosus tubulin alpha chain 0.0205 0.1679 0.2972
Schistosoma mansoni tubulin subunit gamma 0.0147 0.1182 0.2877
Loa Loa (eye worm) hypothetical protein 0.0027 0.0171 0.074
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0012 0.0021
Echinococcus multilocularis beta tubulin 0.027 0.2221 0.3961
Onchocerca volvulus 0.0083 0.0647 0.3972
Loa Loa (eye worm) BEN-1 protein 0.027 0.2221 0.9657
Loa Loa (eye worm) tubulin beta chain 0.0064 0.048 0.2085
Leishmania major beta tubulin 0.027 0.2221 0.5357
Loa Loa (eye worm) tubulin beta-4 chain 0.027 0.2221 0.9657
Brugia malayi MH1 domain containing protein 0.0008 0.0012 0.0049
Echinococcus granulosus alpha tubulin 0.0205 0.1679 0.2972
Echinococcus granulosus epidermal growth factor receptor 0.0059 0.0438 0.0776
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.0182 0.0606
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0315 0.0562
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2328 0.2295
Loa Loa (eye worm) hypothetical protein 0.0083 0.0647 0.2808
Brugia malayi nuclear receptor NHR-88 0.0015 0.0067 0.0298
Echinococcus multilocularis insulin receptor 0.0129 0.1034 0.1843
Toxoplasma gondii aminopeptidase N, putative 0.0015 0.0067 0.011
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0119 0.0947 0.4262
Brugia malayi CXXC zinc finger family protein 0.0028 0.0176 0.079
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0067 0.0298
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0078 0.0138
Onchocerca volvulus Putative sulfate transporter 0.0199 0.1627 1
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0829 0.2018
Trichomonas vaginalis tubulin beta chain, putative 0.0205 0.1679 0.1643
Schistosoma mansoni alpha tubulin 0.0205 0.1679 0.4085
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0119 0.0947 0.4262
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0012 0.0043 0.0076
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0064 0.048 0.0439
Echinococcus granulosus Tubulin beta 2C chain 0.027 0.2221 0.3932
Leishmania major beta tubulin 0.027 0.2221 0.5357
Echinococcus multilocularis FTZ F1 alpha 0.0015 0.0067 0.012
Plasmodium falciparum tubulin beta chain 0.027 0.2221 1
Schistosoma mansoni zinc finger protein 0.0007 0.0001 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.1189 1 1
Brugia malayi Doublecortin family protein 0.0059 0.0443 0.1992
Onchocerca volvulus 0.0015 0.0067 0.0407
Brugia malayi Protein kinase domain containing protein 0.0015 0.0069 0.0309
Echinococcus multilocularis Tubulin beta 2C chain 0.027 0.2221 0.3961
Echinococcus multilocularis RUN 0.0059 0.0443 0.079
Echinococcus granulosus Nuclear hormone receptor HR96 0.0007 0.0001 0.0002
Schistosoma mansoni tyrosine kinase 0.0129 0.1034 0.2515
Schistosoma mansoni netrin receptor unc5 0.0015 0.0069 0.0169
Onchocerca volvulus 0.0012 0.0046 0.0279
Brugia malayi Tubulin alpha-2 chain 0.0205 0.1679 0.7557
Loa Loa (eye worm) hypothetical protein 0.0083 0.0647 0.2808
Entamoeba histolytica tubulin family protein 0.027 0.2221 0.5357
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0315 0.1416
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0829 0.1934
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0067 0.0163
Onchocerca volvulus Dual oxidase homolog 0.0083 0.0647 0.3972
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0015 0.0067 0.0163
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0182 0.0341
Loa Loa (eye worm) tubulin alpha 2 0.0142 0.114 0.4955
Brugia malayi Animal haem peroxidase family protein 0.0083 0.0647 0.2908
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0078 0.0139
Echinococcus multilocularis epidermal growth factor receptor 0.0059 0.0438 0.0782
Onchocerca volvulus 0.0083 0.0644 0.3954
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0182 0.0139
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0279 0.23 0.4102
Loa Loa (eye worm) hypothetical protein 0.0083 0.0647 0.2808
Trichomonas vaginalis tubulin beta chain, putative 0.027 0.2221 0.2188
Schistosoma mansoni tubulin subunit beta 0.027 0.2221 0.5405
Echinococcus multilocularis tubulin gamma 1 chain 0.0147 0.1182 0.2108
Echinococcus multilocularis tubulin subunit TubB 0.0205 0.1679 0.2994
Loa Loa (eye worm) hypothetical protein 0.0051 0.0371 0.161
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0078 0.0139
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0147 0.1182 0.523
Schistosoma mansoni tyrosine kinase 0.0129 0.1034 0.2515
Plasmodium falciparum tubulin gamma chain 0.0147 0.1182 0.523
Echinococcus multilocularis tubulin delta chain 0.0064 0.048 0.0857
Brugia malayi hypothetical protein 0.0008 0.0008 0.0032
Trypanosoma brucei carbonic anhydrase-like protein 0.0119 0.0947 0.4151
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.0829 0.1479
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0015 0.0067 0.012
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0014 0.0058
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0078 0.0335
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0015 0.0067 0.011
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0182 0.0139
Plasmodium vivax tubulin alpha chain, putative 0.0205 0.1679 0.751
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0371 0.161
Loa Loa (eye worm) tubulin alpha 2 0.0059 0.0438 0.1903
Trichomonas vaginalis tubulin beta chain, putative 0.0205 0.1679 0.1643
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0008 0.0008 0.0031
Leishmania major beta tubulin 0.027 0.2221 0.5357
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0015 0.0067 0.0119
Loa Loa (eye worm) hypothetical protein 0.0142 0.114 0.4955
Loa Loa (eye worm) hypothetical protein 0.0083 0.0647 0.2808
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0142 0.114 0.4955
Leishmania major calmodulin, putative 0.0012 0.0046 0.0008
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0829 0.3603
Trichomonas vaginalis tubulin alpha chain, putative 0.0083 0.0644 0.0603
Trypanosoma cruzi aminopeptidase, putative 0.0015 0.0067 0.011
Brugia malayi tubulin alpha chain - mouse 0.0205 0.1679 0.7557
Echinococcus granulosus RUN 0.0059 0.0443 0.0784
Trichomonas vaginalis tubulin beta chain, putative 0.0205 0.1679 0.1643
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.097 0.4214
Schistosoma mansoni loxhd1 0.0059 0.0443 0.1078
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0067 0.0119
Echinococcus granulosus tubulin epsilon chain 0.0147 0.1182 0.2092
Schistosoma mansoni hypothetical protein 0.0016 0.0078 0.0189
Trypanosoma cruzi calmodulin, putative 0.0012 0.0046 0.0015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0067 0.0119
Loa Loa (eye worm) hypothetical protein 0.0083 0.0648 0.2812
Brugia malayi 6-phosphofructokinase 0.0105 0.0829 0.3731
Schistosoma mansoni carbonic anhydrase-related 0.0027 0.0171 0.0416
Loa Loa (eye worm) hypothetical protein 0.0027 0.0171 0.074
Leishmania major beta tubulin 0.027 0.2221 0.5357
Echinococcus granulosus lipoxygenase domain containing protein 0.0059 0.0443 0.0784
Leishmania major beta tubulin 0.027 0.2221 0.5357
Echinococcus multilocularis tubulin alpha 1C chain 0.0205 0.1679 0.2994
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0031
Echinococcus multilocularis Tubulin beta 2C chain 0.027 0.2221 0.3961
Schistosoma mansoni lipoxygenase 0.0166 0.1346 0.3274
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0012 0.0043 0.019
Leishmania major alpha tubulin 0.0205 0.1679 0.4023
Trypanosoma brucei beta tubulin 0.027 0.2221 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0288
Echinococcus multilocularis Tubulin beta 2C chain 0.027 0.2221 0.3961
Echinococcus multilocularis calmodulin 0.0012 0.0046 0.0083
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2328 0.2295
Onchocerca volvulus 0.0199 0.1627 1
Echinococcus granulosus Polycystic kidney disease protein 0.0059 0.0443 0.0784
Echinococcus multilocularis calmodulin 0.0012 0.0046 0.0083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0067 0.0119
Trypanosoma cruzi beta tubulin, putative 0.027 0.2221 1
Echinococcus multilocularis tubulin alpha 0.0147 0.1182 0.2108
Schistosoma mansoni lipoxygenase 0.0059 0.0443 0.1078
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0288
Plasmodium falciparum carbonic anhydrase 0.0027 0.0171 0.0587
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0078 0.0138
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0078 0.0189
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0067 0.0298
Loa Loa (eye worm) hypothetical protein 0.0015 0.0069 0.0298
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0078 0.0159
Mycobacterium ulcerans cell division protein FtsZ 0.0064 0.048 0.0416
Schistosoma mansoni rab6-interacting 0.0059 0.0443 0.1078
Echinococcus granulosus tubulin alpha chain 0.0205 0.1679 0.2972
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0288
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.0829 0.0767
Echinococcus granulosus lipoxygenase domain containing protein 0.0059 0.0443 0.0784
Echinococcus multilocularis Tubulin beta 2C chain 0.027 0.2221 0.3961
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0182 0.0636
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0119 0.0947 0.4116
Schistosoma mansoni hypothetical protein 0.0016 0.0078 0.0189
Echinococcus granulosus tubulin alpha chain 0.0205 0.1679 0.2972
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0315 0.0562
Loa Loa (eye worm) carbonic anhydrase 3 0.0119 0.0947 0.4116
Giardia lamblia Beta tubulin 0.027 0.2221 0.9532
Toxoplasma gondii aminopeptidase n, putative 0.0015 0.0067 0.011
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0069 0.0309
Schistosoma mansoni tubulin subunit beta 0.027 0.2221 0.5405
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0008 0.0008 0.0014
Plasmodium vivax sulfate transporter, putative 0.0032 0.021 0.0767
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0031
Echinococcus granulosus aminopeptidase N 0.0015 0.0067 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0015 0.0067 0.0288
Echinococcus granulosus Tubulin alpha 1 chain 0.0205 0.1679 0.2972
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0119 0.0947 0.2305
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0129 0.1034 0.1829
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0012 0.0021
Echinococcus granulosus tubulin alpha 1C chain 0.0205 0.1679 0.2972
Echinococcus multilocularis tubulin alpha chain 0.0205 0.1679 0.2994
Echinococcus multilocularis Tubulin alpha 1 chain 0.0205 0.1679 0.2994
Brugia malayi alpha-tubulin 0.0205 0.1679 0.7557
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.047 0.3921 0.4871
Echinococcus granulosus smad 0.0008 0.0012 0.0021
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0119 0.0947 0.4151
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0078 0.0137
Echinococcus multilocularis tubulin alpha 3 chain 0.0205 0.1679 0.2994
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0008 0.0008 0.0019
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0439 0.1069
Echinococcus granulosus epidermal growth factor receptor 0.0059 0.0438 0.0776
Echinococcus granulosus muscleblind protein 0.0144 0.1162 0.2056
Schistosoma mansoni peroxidasin 0.0083 0.0648 0.1576
Leishmania major alpha tubulin 0.0205 0.1679 0.4023
Leishmania major beta tubulin 0.027 0.2221 0.5357
Echinococcus granulosus calmodulin 0.0012 0.0046 0.0082
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0829 0.1934
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.021 0.0767
Echinococcus granulosus insulin receptor 0.0129 0.1034 0.1829
Brugia malayi Peptidase family M1 containing protein 0.0015 0.0067 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0067 0.0298
Entamoeba histolytica tubulin family protein 0.027 0.2221 0.5357
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0012 0.0047
Onchocerca volvulus Peroxidasin homolog 0.0083 0.0647 0.3972
Leishmania major beta tubulin 0.027 0.2221 0.5357
Trypanosoma brucei beta tubulin 0.027 0.2221 1
Trypanosoma brucei zeta tubulin 0.0064 0.048 0.2007
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0015 0.0067 0.0298
Onchocerca volvulus Chorion peroxidase homolog 0.0083 0.0647 0.3972
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0078 0.0159
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0235 0.1055
Leishmania major delta tubulin, putative 0.0064 0.048 0.1075
Echinococcus multilocularis tubulin, beta 4A class IVa 0.027 0.2221 0.3961
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0315 0.0767
Schistosoma mansoni hypothetical protein 0.0016 0.0078 0.0189
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0015 0.0067 0.0163
Trypanosoma cruzi zeta tubulin, putative 0.0064 0.048 0.2007
Plasmodium falciparum tubulin delta chain, putative 0.0064 0.048 0.2007
Schistosoma mansoni tyrosine kinase 0.0059 0.0438 0.1067
Echinococcus granulosus tubulin alpha 3 chain 0.0205 0.1679 0.2972
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0027 0.0171 0.0766
Schistosoma mansoni alpha tubulin 0.0205 0.1679 0.4085
Schistosoma mansoni tubulin subunit beta 0.027 0.2221 0.5405
Onchocerca volvulus Bile acid receptor homolog 0.0015 0.0067 0.0407
Trypanosoma brucei Aminopeptidase M1, putative 0.0015 0.0067 0.011
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0069 0.0298
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0012 0.0021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0067 0.012
Brugia malayi Cell division protein ftsZ 0.0064 0.048 0.2159
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0015 0.0067 0.0407
Schistosoma mansoni tubulin subunit beta 0.027 0.2221 0.5405
Loa Loa (eye worm) tubulin beta-2A chain 0.027 0.2221 0.9657
Echinococcus granulosus tubulin gamma 1 chain 0.0147 0.1182 0.2092
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0252 0.2076 0.2533
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.0949 0.7967 1
Loa Loa (eye worm) alpha-tubulin 0.0205 0.1679 0.7298
Echinococcus granulosus hypothetical protein 0.0675 0.565 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0015 0.0067 0.0288
Trichomonas vaginalis tubulin gamma chain, putative 0.0064 0.048 0.0439
Plasmodium vivax calmodulin, putative 0.0012 0.0046 0.0015
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0032 0.021 0.0144
Echinococcus granulosus tubulin alpha 0.0147 0.1182 0.2092
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0067 0.0119
Trichomonas vaginalis tubulin epsilon chain, putative 0.0205 0.1679 0.1643
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0182 0.0636
Loa Loa (eye worm) hypothetical protein 0.0122 0.0977 0.4245
Brugia malayi MH2 domain containing protein 0.0122 0.097 0.4364
Leishmania major beta tubulin 0.027 0.2221 0.5357
Echinococcus multilocularis calmodulin 0.0012 0.0046 0.0083
Brugia malayi hypothetical protein 0.0128 0.1026 0.4617
Echinococcus multilocularis beta tubulin 0.027 0.2221 0.3961
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0067 0.0119
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0014 0.0025
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0315 0.1367
Leishmania major alpha tubulin 0.0205 0.1679 0.4023
Echinococcus multilocularis carbonic anhydrase 0.0027 0.0171 0.0305
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0015 0.0067 0.0288
Echinococcus granulosus geminin 0.0173 0.1401 0.248
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0067 0.0163
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0012 0.0029
Echinococcus granulosus nuclear receptor nhr 48 0.0007 0.0001 0.0002
Schistosoma mansoni smad1 5 8 and 0.0008 0.0012 0.0029
Echinococcus granulosus Tubulin alpha 1 chain 0.0205 0.1679 0.2972
Leishmania major alpha tubulin 0.0205 0.1679 0.4023
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0008 0.0008 0.0019
Onchocerca volvulus 0.0083 0.0647 0.3972
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0015 0.0067 0.0288
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0015 0.0067 0.0163
Leishmania major beta tubulin 0.027 0.2221 0.5357
Trypanosoma cruzi calmodulin, putative 0.0012 0.0046 0.0015
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.0829 0.0953
Echinococcus granulosus calmodulin 0.0012 0.0046 0.0082
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0032 0.021 0.0767
Schistosoma mansoni tubulin subunit alpha 0.0064 0.048 0.1169
Plasmodium vivax tubulin gamma chain, putative 0.0147 0.1182 0.523
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0015 0.0067 0.0163
Schistosoma mansoni nuclear hormone receptor 0.0007 0.0001 0.0002
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0064 0.048 0.2007
Treponema pallidum ATP-binding protein (ylxH-1) 0.0459 0.382 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0078 0.0139
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0166 0.1346 0.24
Onchocerca volvulus 0.0015 0.0067 0.0407
Leishmania major beta tubulin 0.027 0.2221 0.5357
Schistosoma mansoni hypothetical protein 0.0027 0.0171 0.0416
Loa Loa (eye worm) blistered cuticle protein 3 0.0083 0.0647 0.2808
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0015 0.0067 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0067 0.0298
Loa Loa (eye worm) hypothetical protein 0.0083 0.0647 0.2808
Schistosoma mansoni tyrosine kinase 0.0059 0.0438 0.1067
Echinococcus granulosus tubulin delta chain 0.0064 0.048 0.085
Schistosoma mansoni nuclear receptor 0.0007 0.0001 0.0002
Giardia lamblia Alpha-tubulin 0.0205 0.1679 0.7158
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0182 0.0636
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0078 0.0159
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0015 0.0067 0.0024
Toxoplasma gondii beta-tubulin, putative 0.027 0.2221 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0176 0.0763
Echinococcus multilocularis tubulin epsilon chain 0.0147 0.1182 0.2108
Brugia malayi Protein kinase domain containing protein 0.0129 0.1034 0.4651
Echinococcus multilocularis peroxidasin 0.0083 0.0648 0.1155
Loa Loa (eye worm) aminopeptidase N 0.0015 0.0067 0.0288
Brugia malayi hypothetical protein 0.0008 0.0008 0.0032
Schistosoma mansoni tubulin subunit alpha 0.0205 0.1679 0.4085
Loa Loa (eye worm) hypothetical protein 0.0144 0.1162 0.5048
Brugia malayi Smad1 0.0008 0.0012 0.0049
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0015 0.0067 0.0163
Echinococcus granulosus tubulin beta 4A class IVa 0.027 0.2221 0.3932
Treponema pallidum fructose-bisphosphate aldolase 0.0282 0.2328 0.59
Echinococcus multilocularis carbonic anhydrase II 0.0119 0.0947 0.1689
Trichomonas vaginalis tubulin beta chain, putative 0.0083 0.0644 0.0603
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0279 0.23 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2328 0.2295
Trypanosoma cruzi tubulin gamma chain 0.0147 0.1182 0.523
Echinococcus granulosus death domain containing protein 0.0015 0.0069 0.0123
Trypanosoma cruzi calmodulin 0.0012 0.0046 0.0015
Plasmodium vivax multidomain scavenger receptor, putative 0.0059 0.0443 0.1837
Trichomonas vaginalis tubulin gamma chain, putative 0.0147 0.1182 0.1144
Schistosoma mansoni calmodulin 0.0012 0.0046 0.0113
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0182 0.0139
Echinococcus multilocularis cpg binding protein 0.0029 0.019 0.0338
Toxoplasma gondii hypothetical protein 0.0027 0.0171 0.0587
Loa Loa (eye worm) hypothetical protein 0.0083 0.0647 0.2808
Trichomonas vaginalis tubulin gamma chain, putative 0.0147 0.1182 0.1144
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0182 0.0636
Trichomonas vaginalis tubulin alpha chain, putative 0.027 0.2221 0.2188
Brugia malayi tubulin alpha-2 chain 0.0205 0.1679 0.7557
Trypanosoma cruzi Aminopeptidase M1, putative 0.0015 0.0067 0.011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0171 0.074
Loa Loa (eye worm) hypothetical protein 0.0083 0.0647 0.2808
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0829 0.2018
Schistosoma mansoni RAR-like nuclear receptor 0.0015 0.0067 0.0163
Echinococcus granulosus Tubulin beta 2C chain 0.027 0.2221 0.3932
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0015 0.0067 0.0163
Trichomonas vaginalis calmodulin, putative 0.0012 0.0046 0.0003
Onchocerca volvulus 0.0028 0.0176 0.1079
Loa Loa (eye worm) hypothetical protein 0.0154 0.1243 0.5402
Schistosoma mansoni tubulin subunit delta 0.0064 0.048 0.1169
Echinococcus multilocularis muscleblind protein 1 0.0144 0.1162 0.2071
Brugia malayi nuclear receptor RXR 0.0008 0.0008 0.0032
Schistosoma mansoni carbonic anhydrase-related 0.0027 0.0171 0.0416
Echinococcus granulosus peroxidasin 0.0083 0.0648 0.1146
Trypanosoma brucei epsilon tubulin 0.0147 0.1182 0.523
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0015 0.0067 0.011
Onchocerca volvulus 0.0015 0.0067 0.0407
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0015 0.0067 0.012
Brugia malayi Tubulin alpha chain 0.0205 0.1679 0.7557
Giardia lamblia Calmodulin 0.0012 0.0046 0.0015
Brugia malayi MH2 domain containing protein 0.0008 0.0012 0.0049
Brugia malayi TATA binding protein associated factor 0.0015 0.0067 0.0298
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0288
Trichomonas vaginalis tubulin epsilon chain, putative 0.0064 0.048 0.0439
Trypanosoma cruzi aminopeptidase, putative 0.0015 0.0067 0.011
Echinococcus multilocularis Ankyrin 0.0015 0.0071 0.0126
Leishmania major beta tubulin 0.027 0.2221 0.5357
Trichomonas vaginalis tubulin, putative 0.027 0.2221 0.2188
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0015 0.0067 0.0298
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2328 0.2295
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0119 0.0947 0.4151
Leishmania major alpha tubulin 0.0205 0.1679 0.4023
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0069 0.0123
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0001 0.0002
Echinococcus granulosus Tubulin beta 2C chain 0.027 0.2221 0.3932
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0015 0.0067 0.0024
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0493 0.411 1
Echinococcus granulosus calmodulin 0.0012 0.0046 0.0082
Loa Loa (eye worm) BEN-1 protein 0.027 0.2221 0.9657
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0015 0.0067 0.0288
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0015 0.0067 0.0119
Trypanosoma brucei calmodulin 0.0012 0.0046 0.0015
Echinococcus granulosus carbonic anhydrase II 0.0119 0.0947 0.1677
Plasmodium falciparum calmodulin 0.0012 0.0046 0.0015
Schistosoma mansoni carbonic anhydrase-related 0.0027 0.0171 0.0416
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.2328 0.562
Echinococcus granulosus beta tubulin 0.027 0.2221 0.3932
Leishmania major alpha tubulin 0.0205 0.1679 0.4023
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0064 0.048 0.5
Loa Loa (eye worm) TATA binding protein associated factor 0.0015 0.0067 0.0288
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0067 0.0298
Schistosoma mansoni peroxidasin 0.0083 0.0647 0.1573
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0012 0.0021
Echinococcus granulosus carbonic anhydrase 0.0027 0.0171 0.0303
Brugia malayi beta-tubulin, identical 0.027 0.2221 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0647 0.2808
Trichomonas vaginalis tubulin gamma chain, putative 0.027 0.2221 0.2188
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0015 0.0067 0.0298
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0007 0.0001 0.0002
Echinococcus multilocularis Tubulin alpha 1 chain 0.0205 0.1679 0.2994
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0182 0.0636
Leishmania major beta tubulin 0.027 0.2221 0.5357
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0069 0.0124
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0064 0.048 0.2007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2328 0.2295
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0015 0.0067 0.0059
Toxoplasma gondii aminopeptidase N protein 0.0015 0.0067 0.011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0078 0.0345
Onchocerca volvulus Protein ultraspiracle homolog 0.0015 0.0067 0.0407
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0014 0.0025
Entamoeba histolytica carbonic anhydrase, putative 0.0493 0.411 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0178
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0182 0.0139
Echinococcus granulosus Nuclear hormone receptor HR96 0.0007 0.0001 0.0002
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0015 0.0067 0.0288
Schistosoma mansoni hypothetical protein 0.0173 0.1401 0.3409
Loa Loa (eye worm) tubulin alpha-3 chain 0.0122 0.0977 0.4245
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0166 0.1346 0.2382
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0015 0.0067 0.012
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0015 0.0067 0.0024
Mycobacterium ulcerans carbonic anhydrase 0.0493 0.411 0.407
Trypanosoma cruzi calmodulin, putative 0.0012 0.0046 0.0015
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0371 0.1667
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0015 0.0067 0.012
Trichomonas vaginalis tubulin epsilon chain, putative 0.0205 0.1679 0.1643
Onchocerca volvulus 0.0154 0.1243 0.764
Brugia malayi Tubulin alpha-2 chain 0.0205 0.1679 0.7557
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0069 0.0124
Entamoeba histolytica calmodulin, putative 0.0012 0.0046 0.0008
Schistosoma mansoni hypothetical protein 0.0173 0.1401 0.3409
Echinococcus multilocularis Smad4 0.0008 0.0012 0.0021
Leishmania major calmodulin, putative 0.0012 0.0046 0.0008
Loa Loa (eye worm) hypothetical protein 0.0083 0.0647 0.2808
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0182 0.0139
Trypanosoma brucei calmodulin 0.0012 0.0046 0.0015
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0078 0.0159
Brugia malayi Death domain containing protein 0.0015 0.0069 0.0309
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.1108 0.1305
Trypanosoma cruzi tubulin delta chain 0.0064 0.048 0.2007
Echinococcus multilocularis tubulin beta 1 chain 0.027 0.2221 0.3961
Giardia lamblia Delta tubulin 0.0064 0.048 0.1913
Echinococcus granulosus carbonic anhydrase 0.0027 0.0171 0.0303
Toxoplasma gondii beta-1 tubulin, putative 0.027 0.2221 1
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0015 0.0067 0.0059
Echinococcus granulosus leukotriene A 4 hydrolase 0.0279 0.23 0.4071
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0829 0.3603
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0067 0.0119
Echinococcus multilocularis Tubulin alpha 1 chain 0.0205 0.1679 0.2994
Schistosoma mansoni aminopeptidase A (M01 family) 0.0015 0.0067 0.0163
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0288
Onchocerca volvulus Peroxidasin homolog 0.0083 0.0648 0.3978
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0078 0.0085
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0288
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0078 0.0138
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0015 0.0067 0.0163
Echinococcus multilocularis thyroid hormone receptor alpha 0.0015 0.0067 0.012
Echinococcus granulosus tubulin subunit beta 0.027 0.2221 0.3932
Schistosoma mansoni tyrosine kinase 0.0059 0.0438 0.1067
Brugia malayi Blistered cuticle protein 3 0.0083 0.0647 0.2908
Brugia malayi nuclear hormone receptor 0.0015 0.0067 0.0298
Brugia malayi Animal haem peroxidase family protein 0.0083 0.0647 0.2908
Plasmodium vivax tubulin alpha chain, putative 0.0205 0.1679 0.751
Schistosoma mansoni tyrosine kinase 0.0058 0.043 0.1045
Loa Loa (eye worm) hypothetical protein 0.0083 0.0647 0.2808
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0078 0.0346
Echinococcus granulosus GPCR family 2 0.0016 0.0078 0.0137
Onchocerca volvulus Calmodulin homolog 0.0012 0.0046 0.028
Brugia malayi Tubulin alpha chain 0.0064 0.048 0.2159
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0288
Leishmania major carbonic anhydrase family protein, putative 0.0493 0.411 1
Loa Loa (eye worm) steroid hormone receptor 0.0015 0.0067 0.0288
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0129 0.1034 0.1843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0315 0.0767
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0182 0.0139
Trypanosoma brucei beta tubulin 0.027 0.2221 1
Echinococcus multilocularis tubulin alpha chain 0.0205 0.1679 0.2994
Echinococcus granulosus Smad4 0.0008 0.0012 0.0021
Trypanosoma brucei alpha tubulin 0.0205 0.1679 0.751
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.3282 0.5852
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0059 0.0438 0.0776
Echinococcus granulosus tubulin subunit TubB 0.0205 0.1679 0.2972
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0015 0.0067 0.012
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0182 0.0636
Echinococcus granulosus cpg binding protein 0.0029 0.019 0.0336
Schistosoma mansoni tubulin subunit beta 0.027 0.2221 0.5405
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0031
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.021 0.0767
Trichomonas vaginalis tubulin, putative 0.0083 0.0644 0.0603
Brugia malayi isocitrate dehydrogenase 0.0016 0.0078 0.0346
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0043 0.0105
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0078 0.0139
Loa Loa (eye worm) animal heme peroxidase 0.0083 0.0647 0.2808
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0027 0.0171 0.0766
Brugia malayi Animal haem peroxidase family protein 0.0083 0.0647 0.2908
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0067 0.0163
Schistosoma mansoni cpg binding protein 0.0029 0.019 0.0461
Schistosoma mansoni hypothetical protein 0.0395 0.3282 0.7986
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.2328 0.562
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0015 0.0067 0.0298
Trypanosoma brucei beta tubulin 0.027 0.2221 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0083 0.0644 0.0603
Leishmania major beta tubulin 0.027 0.2221 0.5357
Schistosoma mansoni tubulin subunit alpha 0.0205 0.1679 0.4085
Echinococcus multilocularis conserved hypothetical protein 0.067 0.5608 1
Schistosoma mansoni cpg binding protein 0.0028 0.0176 0.0429
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0015 0.0067 0.011
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0829 0.079
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0015 0.0067 0.012
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0303
Onchocerca volvulus 0.0059 0.0443 0.272
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.1108 0.1728
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0371 0.1667
Brugia malayi ecdysteroid receptor 0.0015 0.0067 0.0298
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0015 0.0067 0.0119
Entamoeba histolytica tubulin gamma chain 0.0147 0.1182 0.2801
Plasmodium vivax tubulin beta chain, putative 0.027 0.2221 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0078 0.0334
Echinococcus granulosus Tubulin beta 2C chain 0.027 0.2221 0.3932
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0205 0.1679 0.1643
Giardia lamblia Beta tubulin 0.027 0.2221 0.9532
Brugia malayi Peptidase family M1 containing protein 0.0015 0.0067 0.0298
Echinococcus multilocularis calmodulin 0.0012 0.0046 0.0083
Trypanosoma brucei calmodulin 0.0012 0.0046 0.0015
Loa Loa (eye worm) tubulin beta-1 chain 0.027 0.2221 0.9657
Trypanosoma cruzi calmodulin 0.0012 0.0046 0.0015
Echinococcus multilocularis geminin 0.0173 0.1401 0.2498
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0315 0.0767
Leishmania major alpha tubulin 0.0205 0.1679 0.4023
Leishmania major beta tubulin 0.027 0.2221 0.5357
Trichomonas vaginalis tubulin alpha chain, putative 0.0083 0.0644 0.0603
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0008 0.0008 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0015 0.0067 0.0288
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2328 0.2295
Trichomonas vaginalis tubulin, putative 0.0083 0.0644 0.0603
Loa Loa (eye worm) TK/INSR protein kinase 0.0129 0.1034 0.4491
Toxoplasma gondii beta tubulin 0.027 0.2221 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0031
Echinococcus granulosus tubulin beta 1 chain 0.027 0.2221 0.3932
Giardia lamblia Beta tubulin 0.027 0.2221 0.9532
Echinococcus multilocularis muscleblind protein 0.0144 0.1162 0.2071
Brugia malayi Tubulin beta-1 chain 0.027 0.2221 1
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0829 0.079
Brugia malayi hypothetical protein 0.0059 0.0443 0.1992
Loa Loa (eye worm) beta-tubulin 0.027 0.2221 0.9657
Brugia malayi Animal haem peroxidase family protein 0.0083 0.0647 0.2908
Leishmania major carbonic anhydrase-like protein 0.0119 0.0947 0.2223
Schistosoma mansoni Smad4 0.0008 0.0012 0.0029
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0078 0.0159
Loa Loa (eye worm) hypothetical protein 0.0012 0.0043 0.0184
Loa Loa (eye worm) tubulin alpha chain 0.0205 0.1679 0.7298
Echinococcus granulosus carbonic anhydrase 0.0027 0.0171 0.0303
Schistosoma mansoni hypothetical protein 0.0059 0.0443 0.1078
Loa Loa (eye worm) hypothetical protein 0.0083 0.0647 0.2808
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0067 0.0119
Schistosoma mansoni nuclear hormone receptor 0.0007 0.0001 0.0002
Toxoplasma gondii alpha tubulin TUBA1 0.0205 0.1679 0.751
Echinococcus granulosus calmodulin 0.0012 0.0046 0.0082
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0288
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0829 0.1934
Echinococcus granulosus FTZ F1 alpha 0.0015 0.0067 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.048 0.0439
Giardia lamblia Alpha-tubulin 0.0205 0.1679 0.7158
Loa Loa (eye worm) alpha-tubulin 0.0205 0.1679 0.7298
Schistosoma mansoni retinoic acid receptor RXR 0.0015 0.0067 0.0163
Echinococcus granulosus nuclear factor of activated T cells 5 0.0077 0.0596 0.1054
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0007 0.0001 0.0002
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0013 0.0056
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0829 0.079
Onchocerca volvulus 0.0015 0.0067 0.0407
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2328 0.2295
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.048 0.0439
Brugia malayi hypothetical protein 0.0015 0.0067 0.0298
Trichomonas vaginalis tubulin beta chain, putative 0.0205 0.1679 0.1643
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.1108 0.1048
Brugia malayi hypothetical protein 0.0059 0.0443 0.1992
Schistosoma mansoni tubulin subunit alpha 0.0205 0.1679 0.4085
Giardia lamblia Epsilon tubulin 0.0064 0.048 0.1913
Echinococcus multilocularis tubulin subunit beta 0.027 0.2221 0.3961
Trypanosoma brucei Aminopeptidase M1, putative 0.0015 0.0067 0.011
Schistosoma mansoni tubulin subunit beta 0.0064 0.048 0.1169
Brugia malayi Steroid receptor seven-up type 2 0.0015 0.0067 0.0298
Echinococcus multilocularis 0.0012 0.0043 0.0077
Trypanosoma cruzi epsilon tubulin, putative 0.0147 0.1182 0.523
Brugia malayi Animal haem peroxidase family protein 0.0083 0.0647 0.2908
Trypanosoma cruzi zeta tubulin, putative 0.0064 0.048 0.2007
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0027 0.0171 0.074
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0001 0.0002
Leishmania major alpha tubulin 0.0205 0.1679 0.4023
Echinococcus multilocularis calmodulin 0.0012 0.0046 0.0083
Loa Loa (eye worm) animal heme peroxidase 0.0083 0.0647 0.2808
Entamoeba histolytica tubulin alpha chain, putative 0.0205 0.1679 0.4023
Loa Loa (eye worm) hypothetical protein 0.0205 0.1679 0.7298
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0015 0.0067 0.0059
Leishmania major alpha tubulin 0.0205 0.1679 0.4023
Loa Loa (eye worm) TK/EGFR protein kinase 0.0059 0.0438 0.1903
Echinococcus granulosus Tubulin beta 2C chain 0.027 0.2221 0.3932
Brugia malayi Muscleblind-like protein 0.0144 0.1162 0.5227
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0012 0.0043 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0015 0.0067 0.0298
Echinococcus multilocularis hypothetical protein 0.0205 0.1679 0.2994
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0015 0.0067 0.0298
Echinococcus multilocularis peroxisome assembly protein 26 0.0205 0.1679 0.2994
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0069 0.0169
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0078 0.0139
Schistosoma mansoni tubulin subunit epsilon 0.0147 0.1182 0.2877
Plasmodium falciparum alpha tubulin 1 0.0205 0.1679 0.751
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0071 0.0172
Treponema pallidum cell division protein FtsZ 0.0064 0.048 0.0821
Echinococcus granulosus tubulin alpha 3 chain 0.0205 0.1679 0.2972
Schistosoma mansoni nuclear receptor nhr-48 0.0007 0.0001 0.0002
Trypanosoma cruzi tubulin delta chain 0.0064 0.048 0.2007
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0083 0.0644 0.0603
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0067 0.0298
Echinococcus granulosus tubulin alpha chain 0.0205 0.1679 0.2972
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0015 0.0067 0.011
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0078 0.0345
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0015 0.0067 0.0298
Brugia malayi Tubulin beta chain 0.0083 0.0644 0.2895
Onchocerca volvulus Peroxidase homolog 0.0083 0.0647 0.3972
Leishmania major calmodulin, putative 0.0012 0.0046 0.0008
Echinococcus granulosus tubulin alpha chain 0.0205 0.1679 0.2972
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0069 0.0123
Brugia malayi phosphofructokinase 0.0105 0.0829 0.3731
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0069 0.0422
Echinococcus multilocularis ecdysone induced protein 78C 0.0015 0.0067 0.012
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0015 0.0067 0.011
Trypanosoma brucei calmodulin 0.0012 0.0046 0.0015
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0015 0.0067 0.0059
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0027 0.0171 0.0766
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0182 0.0139
Brugia malayi 6-phosphofructokinase 0.0105 0.0829 0.3731
Loa Loa (eye worm) tubulin alpha 2 0.0142 0.114 0.4955
Trypanosoma brucei beta tubulin 0.0147 0.1182 0.523
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0007 0.0001 0.0002
Toxoplasma gondii alpha-tubulin I, putative 0.0205 0.1679 0.751
Trypanosoma brucei alpha tubulin, putative 0.0083 0.0644 0.2757
Schistosoma mansoni hypothetical protein 0.0015 0.0069 0.0169
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0142 0.114 0.1102
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0067 0.012
Trichomonas vaginalis tubulin epsilon chain, putative 0.027 0.2221 0.2188
Trichomonas vaginalis tubulin alpha chain, putative 0.0147 0.1182 0.1144
Plasmodium falciparum LCCL domain-containing protein 0.0059 0.0443 0.1837
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.0829 0.178
Schistosoma mansoni polycystin 1-related 0.0059 0.0443 0.1078
Echinococcus multilocularis tubulin alpha chain 0.0205 0.1679 0.2994
Loa Loa (eye worm) hypothetical protein 0.0035 0.0235 0.1019
Schistosoma mansoni coup transcription factor 0.0015 0.0067 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.1189 1 1
Brugia malayi MH2 domain containing protein 0.0008 0.0012 0.0049
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0119 0.0947 0.2305
Echinococcus multilocularis epidermal growth factor receptor 0.0059 0.0438 0.0782
Schistosoma mansoni cpg binding protein 0.0029 0.019 0.0461
Trypanosoma brucei aminopeptidase, putative 0.0015 0.0067 0.011
Brugia malayi calmodulin 0.0012 0.0046 0.0205
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0122 0.0977 0.0938
Mycobacterium ulcerans integral membrane transporter 0.0032 0.021 0.0144
Echinococcus multilocularis lipoxygenase domain containing protein 0.0059 0.0443 0.079
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0078 0.0159
Echinococcus granulosus beta tubulin 0.027 0.2221 0.3932
Schistosoma mansoni nuclear receptor 0.0007 0.0001 0.0002
Echinococcus multilocularis carbonic anhydrase 0.0027 0.0171 0.0305
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0288
Brugia malayi hypothetical protein 0.0015 0.0067 0.0298
Echinococcus multilocularis tubulin alpha 1C chain 0.0205 0.1679 0.2994
Loa Loa (eye worm) tubulin alpha chain 0.0205 0.1679 0.7298
Leishmania major alpha tubulin 0.0205 0.1679 0.4023
Loa Loa (eye worm) hypothetical protein 0.0083 0.0647 0.2808
Trypanosoma brucei alpha tubulin 0.0205 0.1679 0.751
Leishmania major beta tubulin 0.027 0.2221 0.5357
Schistosoma mansoni tyrosine kinase 0.0058 0.043 0.1045
Echinococcus multilocularis smad 0.0008 0.0012 0.0021
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0012 0.0047
Echinococcus multilocularis nuclear receptor nhr 48 0.0007 0.0001 0.0002
Trypanosoma brucei epsilon tubulin 0.0147 0.1182 0.523
Echinococcus multilocularis GPCR, family 2 0.0016 0.0078 0.0138
Mycobacterium tuberculosis Cell division protein FtsZ 0.0064 0.048 0.051
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0015 0.0067 0.012
Brugia malayi Tubulin beta chain 0.0064 0.048 0.2159
Brugia malayi Peroxidasin 0.0083 0.0648 0.2912
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.097 0.4214
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0032 0.021 0.0767
Echinococcus granulosus ecdysone induced protein 78C 0.0015 0.0067 0.0119
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0015 0.0067 0.011
Loa Loa (eye worm) tubulin beta chain 0.027 0.2221 0.9657
Onchocerca volvulus 0.0059 0.0443 0.272
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0015 0.0067 0.0163
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0032 0.021 0.0144
Leishmania major beta tubulin 0.027 0.2221 0.5357
Schistosoma mansoni hypothetical protein 0.0012 0.0042 0.0102
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0007 0.0001 0.0002
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0027 0.0171 0.0766
Loa Loa (eye worm) hypothetical protein 0.0012 0.0046 0.0198
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0027 0.0171 0.0766
Loa Loa (eye worm) hypothetical protein 0.0083 0.0647 0.2808
Brugia malayi steroid hormone receptor 0.0015 0.0067 0.0298
Echinococcus granulosus thyroid hormone receptor alpha 0.0007 0.0001 0.0002
Brugia malayi Nuclear hormone receptor-like 1 0.0008 0.0008 0.0032
Echinococcus multilocularis CalModulin family member (cmd 1) 0.0012 0.0046 0.0083
Trypanosoma brucei zeta tubulin, putative 0.0064 0.048 0.2007
Echinococcus multilocularis tubulin alpha 3 chain 0.0205 0.1679 0.2994
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0315 0.0558
Plasmodium vivax tubulin epsilon chain, putative 0.0147 0.1182 0.523
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0182 0.0636
Entamoeba histolytica aminopeptidase, putative 0.0015 0.0067 0.0059
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0007 0.0001 0.0002
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0015 0.0067 0.011
Brugia malayi Nuclear hormone receptor-like 1 0.0008 0.0008 0.0032
Chlamydia trachomatis sulfate transporter 0.0032 0.021 1
Loa Loa (eye worm) phosphofructokinase 0.0105 0.0829 0.3603

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 3 uM Inhibitory activity was determined against Leukotriene A4 hydrolase ChEMBL. 10691697
IC50 (functional) > 3 uM Inhibitory activity was determined for LTB4 production in human whole blood. ChEMBL. 10691697
IC50 (binding) > 3 uM Inhibitory activity was determined against Leukotriene A4 hydrolase ChEMBL. 10691697
IC50 (functional) > 3 uM Inhibitory activity was determined for LTB4 production in human whole blood. ChEMBL. 10691697

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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